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There is low confidence in projections of Antarctic sea ice area (SIA), due to deficiencies in climate model sea ice processes. Ensemble regression techniques can help to reduce this uncertainty. We investigate relationships between SIA climatology and 21st century change in the Coupled Model Intercomparison Project, phase 6 (CMIP6) multi‐model ensemble. In summer, under a strong forcing scenario, each model loses the majority of its sea ice. Therefore, models with greater historical SIA exhibit greater reductions, so the observed climatology of SIA strongly constrains projections. Ensemble spread in historical summer SIA is smaller than in CMIP phase 5 (CMIP5), and CMIP6 gives a more robust constraint on future SIA. In winter, by 2100 under a strong forcing scenario, 40% of SIA disappears on average, and ensemble spread in historical mean SIA explains approximately half the spread in projected change. A greater winter ice loss in CMIP6 than CMIP5 is explained by the higher climate sensitivities of some CMIP6 models. Antarctic sea ice area is important for ecosystems, human activity, and for the dynamics of the atmosphere and ocean. However, major climate change assessments such as the Intergovernmental Panel on Climate Change Sixth Assessment Report have placed little confidence in projections of Antarctic sea ice area. This is because climate models struggle to simulate many aspects of sea ice area as observed by satellites. However, not all models should be treated equally. Models with relatively more sea ice area in the recent past project greater losses in the future, especially in summer. This suggests that models with historical sea ice area closest to what we have observed may be more reliable in their future simulations. We use this information in a simple statistical model to show that, firstly, the newest climate models largely show near‐total sea ice loss in summer by the end of the 21st century, which was not universally true for older climate models. Secondly, newer climate models lose more winter sea ice than their predecessors in the same time period, which is related to the known greater global warming response to given greenhouse gas concentrations in the newer models. We compare Coupled Model Intercomparison Project (CMIP), phase 5 and the CMIP, phase 6 (CMIP6) projections of Antarctic sea ice loss, assessing drivers of uncertainty and the robustness of projectionsUnder strong forcing, CMIP6 models lose most Antarctic summer sea ice by 2100, so projections are constrained by historical climatologyIncreased winter sea ice loss in CMIP6 is related to increased equilibrium climate sensitivity We compare Coupled Model Intercomparison Project (CMIP), phase 5 and the CMIP, phase 6 (CMIP6) projections of Antarctic sea ice loss, assessing drivers of uncertainty and the robustness of projections Under strong forcing, CMIP6 models lose most Antarctic summer sea ice by 2100, so projections are constrained by historical climatology Increased winter sea ice loss in CMIP6 is related to increased equilibrium climate sensitivity