32 results on '"Bijlenga, Philippe"'
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2. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
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Bakker, Mark K., Kanning, Jos P., Abraham, Gad, Martinsen, Amy E., Winsvold, Bendik S., Zwart, John-Anker, Bourcier, Romain, Sawada, Tomonobu, Koido, Masaru, Kamatani, Yoichiro, Morel, Sandrine, Amouyel, Philippe, Debette, Stéphanie, Bijlenga, Philippe, Berrandou, Takiy, Ganesh, Santhi K., Bouatia-Naji, Nabila, Jones, Gregory, Bown, Matthew, Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Hege Aamodt, Anne, Heidi Skogholt, Anne, Brumpton, Ben M, Willer, Cristen J, Sandset, Else C, Kristoffersen, Espen S, Ellekjær, Hanne, Heuch, Ingrid, Nielsen, Jonas B, Hagen, Knut, Hveem, Kristian, Fritsche, Lars G, Thomas, Laurent F, Pedersen, Linda M, Gabrielsen, Maiken E, Holmen, Oddgeir L, Børte, Sigrid, Zhou, Wei, Abboud, Shérine, Pandolfo, Massimo, Thijs, Vincent, Leys, Didier, Bodenant, Marie, Louillet, Fabien, Touzé, Emmanuel, Mas, Jean-Louis, Samson, Yves, Leder, Sara, Léger, Anne, Deltour, Sandrine, Crozier, Sophie, Méresse, Isabelle, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Béjot, Yannick, Decavel, Pierre, Medeiros, Elizabeth, Montiel, Paola, Moulin, Thierry, Vuillier, Fabrice, Dallongeville, Jean, Metso, Antti J, Metso, Tiina, Tatlisumak, Turgut, Grond-Ginsbach, Caspar, Lichy, Christoph, Kloss, Manja, Werner, Inge, Arnold, Marie-Luise, Dos Santos, Michael, Grau, Armin, Dichgans, Martin, Thomas-Feles, Constanze, Weber, Ralf, Brandt, Tobias, Pezzini, Alessandro, De Giuli, Valeria, Caria, Filomena, Poli, Loris, Padovani, Alessandro, Bersano, Anna, Lanfranconi, Silvia, Beretta, Simone, Ferrarese, Carlo, Giacolone, Giacomo, Paolucci, Stefano, Lyrer, Philippe, Engelter, Stefan, Fluri, Felix, Hatz, Florian, Gisler, Dominique, Bonati, Leo, Gensicke, Henrik, Amort, Margareth, Markus, Hugh, Majersik, Jennifer, Worrall, Bradford, Southerland, Andrew, Cole, John, Kittner, Steven, Evangelou, Evangelos, Warren, Helen R, Gao, He, Ntritsos, Georgios, Dimou, Niki, Esko, Tonu, Mägi, Reedik, Milani, Lili, Almgren, Peter, Boutin, Thibaud, Ding, Jun, Giulianini, Franco, Holliday, Elizabeth G, Jackson, Anne U, Li-Gao, Ruifang, Lin, Wei-Yu, Luan, Jian’an, Mangino, Massimo, Oldmeadow, Christopher, Peter Prins, Bram, Qian, Yong, Sargurupremraj, Muralidharan, Shah, Nabi, Surendran, Praveen, Thériault, Sébastien, Verweij, Niek, Willems, Sara M, Zhao, Jing-Hua, Connell, John, de Mutsert, Renée, Doney, Alex SF, Farrall, Martin, Menni, Cristina, Morris, Andrew D, Noordam, Raymond, Paré, Guillaume, Poulter, Neil R, Shields, Denis C, Stanton, Alice, Thom, Simon, Abecasis, Gonçalo, Amin, Najaf, Arking, Dan E, Ayers, Kristin L, Barbieri, Caterina M, Batini, Chiara, Bis, Joshua C, Blake, Tineka, Bochud, Murielle, Boehnke, Michael, Boerwinkle, Eric, Boomsma, Dorret I, Bottinger, Erwin P, Braund, Peter S, Brumat, Marco, Campbell, Archie, Campbell, Harry, Chakravarti, Aravinda, Chambers, John C, Chauhan, Ganesh, Ciullo, Marina, Cocca, Massimiliano, Collins, Francis, Cordell, Heather J, Davies, Gail, de Borst, Martin H, de Geus, Eco J, Deary, Ian J, Deelen, Joris, Del Greco M, Fabiola, Yusuf Demirkale, Cumhur, Dörr, Marcus, Ehret, Georg B, Elosua, Roberto, Enroth, Stefan, Mesut Erzurumluoglu, A, Ferreira, Teresa, Frånberg, Mattias, Franco, Oscar H, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Goel, Anuj, Gow, Alan J, Gudnason, Vilmundur, Guo, Xiuqing, Gyllensten, Ulf, Hamsten, Anders, Harris, Tamara B, Harris, Sarah E, Hartman, Catharina A, Havulinna, Aki S, Hicks, Andrew A, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Shih-Jen, Ingelsson, Erik, James, Alan, Jansen, Rick, Jarvelin, Marjo-Riitta, Joehanes, Roby, Johansson, Åsa, Johnson, Andrew D, Joshi, Peter K, Jousilahti, Pekka, Wouter Jukema, J, Jula, Antti, Kähönen, Mika, Kathiresan, Sekar, Keavney, Bernard D, Khaw, Kay-Tee, Knekt, Paul, Knight, Joanne, Kolcic, Ivana, Kooner, Jaspal S, Koskinen, Seppo, Kristiansson, Kati, Kutalik, Zoltan, Laan, Maris, Larson, Marty, Launer, Lenore J, Lehne, Benjamin, Lehtimäki, Terho, Liewald, David CM, Lin, Li, Lind, Lars, Lindgren, Cecilia M, Liu, YongMei, Loos, Ruth JF, Lopez, Lorna M, Lu, Yingchang, Lyytikäinen, Leo-Pekka, Mahajan, Anubha, Mamasoula, Chrysovalanto, Marrugat, Jaume, Marten, Jonathan, Milaneschi, Yuri, Morgan, Anna, Morris, Andrew P, Morrison, Alanna C, Munson, Peter J, Nalls, Mike A, Nandakumar, Priyanka, Nelson, Christopher P, Niiranen, Teemu, Nolte, Ilja M, Nutile, Teresa, Oldehinkel, Albertine J, Oostra, Ben A, O’Reilly, Paul F, Org, Elin, Padmanabhan, Sandosh, Palmas, Walter, Palotie, Aarno, Pattie, Alison, WJH Penninx, Brenda, Perola, Markus, Peters, Annette, Polasek, Ozren, Pramstaller, Peter P, Tri Nguyen, Quang, Raitakari, Olli T, Rettig, Rainer, Rice, Kenneth, Ridker, Paul M, Ried, Janina S, Riese, Harriëtte, Ripatti, Samuli, Robino, Antonietta, Rose, Lynda M, Rotter, Jerome I, Rudan, Igor, Ruggiero, Daniela, Saba, Yasaman, Sala, Cinzia F, Salomaa, Veikko, Samani, Nilesh J, Sarin, Antti-Pekka, Schmidt, Reinhold, Schmidt, Helena, Shrine, Nick, Siscovick, David, Smith, Albert V, Snieder, Harold, Sõber, Siim, Sorice, Rossella, Starr, John M, Stott, David J, Strachan, David P, Strawbridge, Rona J, Sundström, Johan, Swertz, Morris A, Taylor, Kent D, Teumer, Alexander, Tobin, Martin D, Tomaszewski, Maciej, Toniolo, Daniela, Traglia, Michela, Trompet, Stella, Tuomilehto, Jaakko, Tzourio, Christophe, Uitterlinden, André G, Vaez, Ahmad, van der Most, Peter J, van Duijn, Cornelia M, Verwoert, Germaine C, Vitart, Veronique, Völker, Uwe, Vollenweider, Peter, Vuckovic, Dragana, Watkins, Hugh, Wild, Sarah H, Willemsen, Gonneke, Wilson, James F, Wright, Alan F, Yao, Jie, Zemunik, Tatijana, Zhang, Weihua, Attia, John R, Butterworth, Adam S, Chasman, Daniel I, Conen, David, Cucca, Francesco, Danesh, John, Hayward, Caroline, Howson, Joanna MM, Laakso, Markku, Lakatta, Edward G, Langenberg, Claudia, Melander, Olle, Mook-Kanamori, Dennis O, Palmer, Colin NA, Risch, Lorenz, Scott, Robert A, Scott, Rodney J, Sever, Peter, Spector, Tim D, van der Harst, Pim, Wareham, Nicholas J, Zeggini, Eleftheria, Levy, Daniel, Munroe, Patricia B, Newton-Cheh, Christopher, Brown, Morris J, Metspalu, Andres, Psaty, Bruce M., Wain, Louise V, Elliott, Paul, Caulfield, Mark J, Gormley, Padhraig, Anttila, Verneri, Palta, Priit, Esko, Tonu, Pers, Tune H, Farh, Kai-How, Cuenca-Leon, Ester, Muona, Mikko, Furlotte, Nicholas A, Kurth, Tobias, Ingason, Andres, McMahon, George, Ligthart, Lannie, Terwindt, Gisela M, Kallela, Mikko, Freilinger, Tobias M, Ran, Caroline, Gordon, Scott G, Stam, Anine H, Steinberg, Stacy, Borck, Guntram, Koiranen, Markku, Quaye, Lydia, Adams, Hieab H H, Lehtimäki, Terho, Sarin, Antti-Pekka, Wedenoja, Juho, Hinds, David A, Buring, Julie E, Schürks, Markus, Ridker, Paul M, Gudlaug Hrafnsdottir, Maria, Stefansson, Hreinn, Ring, Susan M, Hottenga, Jouke-Jan, Penninx, Brenda W J H, Färkkilä, Markus, Artto, Ville, Kaunisto, Mari, Vepsäläinen, Salli, Malik, Rainer, Heath, Andrew C, Madden, Pamela A F, Martin, Nicholas G, Montgomery, Grant W, Kurki, Mitja I, Kals, Mart, Mägi, Reedik, Pärn, Kalle, Hämäläinen, Eija, Huang, Hailiang, Byrnes, Andrea E, Franke, Lude, Huang, Jie, Stergiakouli, Evie, Lee, Phil H, Sandor, Cynthia, Webber, Caleb, Cader, Zameel, Muller-Myhsok, Bertram, Schreiber, Stefan, Meitinger, Thomas, Eriksson, Johan G, Salomaa, Veikko, Heikkilä, Kauko, Loehrer, Elizabeth, Uitterlinden, Andre G, Hofman, Albert, van Duijn, Cornelia M, Cherkas, Lynn, Pedersen, Linda M, Stubhaug, Audun, Nielsen, Christopher S, Männikkö, Minna, Mihailov, Evelin, Milani, Lili, Göbel, Hartmut, Esserlind, Ann-Louise, Francke Christensen, Anne, Folkmann Hansen, Thomas, Werge, Thomas, Kaprio, Jaakko, Aromaa, Arpo J, Raitakari, Olli, Arfan Ikram, M, Spector, Tim, Järvelin, Marjo-Riitta, Metspalu, Andres, Kubisch, Christian, Strachan, David P, Ferrari, Michel D, Belin, Andrea C, Dichgans, Martin, Wessman, Maija, van den Maagdenberg, Arn M J M, Boomsma, Dorret I, Davey Smith, George, Stefansson, Kari, Eriksson, Nicholas, Daly, Mark J, Neale, Benjamin M, Olesen, Jes, Chasman, Daniel I, Nyholt, Dale R, Palotie, Aarno, Akiyama, Masato, Alg, Varinder S., Børte, Sigrid, Broderick, Joseph P., Brumpton, Ben M., Dauvillier, Jérôme, Desal, Hubert, Dina, Christian, Friedrich, Christoph M., Gaál-Paavola, Emília I., Gentric, Jean-Christophe, Hirsch, Sven, Hostettler, Isabel C., Houlden, Henry, Hveem, Kristian, Jääskeläinen, Juha E., Johnsen, Marianne Bakke, Li, Liming, Lin, Kuang, Lindgren, Antti, Martin, Olivier, Matsuda, Koichi, Millwood, Iona Y., Naggara, Olivier, Niemelä, Mika, Pera, Joanna, Redon, Richard, Rouleau, Guy A., Sandvei, Marie Søfteland, Schilling, Sabine, Shotar, Eimad, Slowik, Agnieszka, Terao, Chikashi, Verschuren, W. M. Monique, Walters, Robin G., Werring, David J., Willer, Cristen J., Woo, Daniel, Worrall, Bradford B., and Zhou, Sirui
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- 2023
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3. Impact of Very Small Aneurysm Size and Anterior Communicating Segment Location on Outcome after Aneurysmal Subarachnoid Hemorrhage
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Roethlisberger, Michel, Aghlmandi, Soheila, Rychen, Jonathan, Chiappini, Alessio, Zumofen, Daniel W., Bawarjan, Schatlo, Stienen, Martin N., Fung, Christian, D'Alonzo, Donato, Maldaner, Nicolai, Steinsiepe, Valentin K., Corniola, Marco V., Goldberg, Johannes, Cianfoni, Alessandro, Robert, Thomas, Maduri, Rodolfo, Saliou, Guillaume, Starnoni, Daniele, Weber, Johannes, Seule, Martin A., Gralla, Jan, Bervini, David, Kulcsar, Zsolt, Burkhardt, Jan-Karl, Bozinov, Oliver, Remonda, Luca, Marbacher, Serge, Lövblad, Karl-Olof, Psychogios, Marios, Bucher, Heiner C., Mariani, Luigi, Bijlenga, Philippe, Blackham, Kristine A., and Guzman, Raphael
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- 2023
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4. External Validation of the HATCH (Hemorrhage, Age, Treatment, Clinical State, Hydrocephalus) Score for Prediction of Functional Outcome After Subarachnoid Hemorrhage
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Maldaner, Nicolai, Visser, Victoria, Hostettler, Isabel Charlotte, Bijlenga, Philippe, Haemmerli, Julien, Roethlisberger, Michel, Guzman, Raphael, Daniel, Roy Thomas, Giammattei, Lorenzo, Stienen, Martin Nikolaus, Regli, Luca, Verbaan, Dagmar, Post, René, and Germans, Menno Robbert
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- 2022
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5. Herniation World Federation of Neurosurgical Societies Scale Improves Prediction of Outcome in Patients With Poor-Grade Aneurysmal Subarachnoid Hemorrhage
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Raabe, Andreas, Beck, Jürgen, Goldberg, Johannes, Z´Graggen, Werner J., Branca, Mattia, Marbacher, Serge, D’Alonzo, Donato, Fandino, Javier, Stienen, Martin N., Neidert, Marian C., Burkhardt, Jan-Karl, Regli, Luca, Hlavica, Martin, Seule, Martin, Roethlisberger, Michel, Guzman, Raphael, Zumofen, Daniel Walter, Maduri, Rodolfo, Daniel, Roy Thomas, El Rahal, Amir, Corniola, Marco V., Bijlenga, Philippe, Schaller, Karl, Rölz, Roland, Scheiwe, Christian, Shah, Mukesch, Heiland, Dieter Henrik, Schnell, Oliver, and Fung, Christian
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- 2022
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6. Sex Difference and Rupture Rate of Intracranial Aneurysms: An Individual Patient Data Meta-Analysis
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Zuurbier, Charlotte C.M., Molenberg, Rob, Mensing, Liselore A., Wermer, Marieke J.H., Juvela, Seppo, Lindgren, Antti E., Jääskeläinen, Juha E., Koivisto, Timo, Yamazaki, Tomosato, Uyttenboogaart, Maarten, van Dijk, J. Marc C., Aalbers, Marlien W., Morita, Akio, Tominari, Shinjiro, Arai, Hajime, Nozaki, Kazuhiko, Murayama, Yuichi, Ishibashi, Toshihiro, Takao, Hiroyuki, Gondar, Renato, Bijlenga, Philippe, Rinkel, Gabriel J.E., Greving, Jacoba P., and Ruigrok, Ynte M.
- Abstract
Supplemental Digital Content is available in the text.
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- 2022
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7. Measuring the Impact of Delayed Cerebral Ischemia on Neuropsychological Outcome After Aneurysmal Subarachnoid Hemorrhage—Protocol of a Swiss Nationwide Observational Study (MoCA–DCI Study)
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Stienen, Martin N, Fung, Christian, Bijlenga, Philippe, Zumofen, Daniel W, Maduri, Rodolfo, Robert, Thomas, Seule, Martin A, Marbacher, Serge, Geisseler, Olivia, Brugger, Peter, Gutbrod, Klemens, Chicherio, Christian, Monsch, Andreas U, Beaud, Valérie, Rossi, Stefania, Früh, Severin, Schmid, Nicole, Smoll, Nicolas R, Keller, Emanuela, Regli, Luca, Bozinov, Oliver, Burkhardt, Jan-Karl, Esposito, Giuseppe, Germans, Menno R, Keller, Emanuela, Krayenbühl, Niklaus, Maldaner, Nicolai, Neidert, Marian C, Regli, Luca, Sebök, Martina, Serra, Carlo, Stienen, Martin N, Velz, Julia, Marbacher, Serge, Fandino, Javier, D’Alonzo, Donato, Galiagousis, Christine, Perren, Carline, Stoller, Andrea, Nedeltchev, Krassen, Guzman, Raphael, Mariani, Luigi, Zumofen, Daniel W, Schulz, Marianne, Neddersen, Heike, Blackham, Kristine, Beck, Jürgen, Fung, Christian, Goldberg, Johannes, Raabe, Andreas, Schöni, Daniel, Bartoli, Andrea, Baticam, Nalla Silva, Bijlenga, Philippe, Constanthin, Paul, Corniola, Marco, Goga, Cristina, Guatta, Ramona, Jannelli, Gianpaolo, May, Adrien, Moiraghi, Alessandro, Molliqaj, Granit, Schaller, Karl, Sprenger, Lima, Wälchli, Thomas, Daniel, Roy Thomas, Maduri, Rodolfo, Rocca, Alda, Chiappini, Alessio, Reinert, Michael, Robert, Thomas, Hlavica, Martin, Killeen, Timothy, Seule, Martin A, Weyerbrock, Astrid, Schmid, Nicole, Kälin, Andrea, Monsch, Andreas U, Waldmeier, Anja Larissa, Albert, Djana, Baas, Ulrike, Cazzoli, Dario, Chavas, Silvia, Gutbrod, Barbara, Gutbrod, Klemens, Heinemann, Dörthe, Hofer, Helene, Chicherio, Christian, Beaud, Valérie, Fiorillo, Léa, Wahl, Laurance, Rossi, Stefania, Zanchi, Fabiana, Früh, Severin, Zimmerer, Sylvia, Schwind, Marc, Brugger, Peter, Dannecker, Noemi, Geisseler, Olivia, Rothacher, Yannick, Schlosser, Ladina, Smoll, Nicolas R, Zweifel-Zehnder, Antoinette E, and Schatlo, Bawarjan
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- 2019
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8. The Barrow Neurological Institute Grading Scale as a Predictor for Delayed Cerebral Ischemia and Outcome After Aneurysmal Subarachnoid Hemorrhage: Data From a Nationwide Patient Registry (Swiss SOS)
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Neidert, Marian Christoph, Maldaner, Nicolai, Stienen, Martin Nikolaus, Roethlisberger, Michel, Zumofen, Daniel W, D’Alonzo, Donato, Marbacher, Serge, Maduri, Rodolfo, Hostettler, Isabel Charlotte, Schatlo, Bawarjan, Schneider, Michel M, Seule, Martin A, Schöni, Daniel, Goldberg, Johannes, Fung, Christian, Arrighi, Marta, Valsecchi, Daniele, Bijlenga, Philippe, Schaller, Karl, Bozinov, Oliver, Regli, Luca, Burkhardt, Jan-Karl, Fandino, Javier, Marbacher, Serge, D'Alonzo, Donato, Coluccia, Daniel, Schmid, Nicole, Zumofen, Daniel, Roethlisberger, Michel, Mariani, Luigi, Guzman, Raphael, Monsch, Andreas U, Bläsi, Stephan, Fung, Christian, Bervini, David, Beck, Jürgen, Raabe, Andreas, Goldberg, Johannes, Schöni, Daniel, Gralla, Jan, Zweifel-Zehnder, Antoinette, Gutbrod, Klemens, Müri, Rene, Maduri, Rodolfo, Thomas Daniel, Roy, Starnoni, Daniele, Messerer, Mahmoud, Levivier, Marc, Beaud, Valérie, Valsecchi, Daniele, Arrighi, Marta, Venier, Alice, Reinert, Michael, Kuhlen, Dominique E, Robert, Thomas, Rossi, Stefania, Sacco, Leonardo, Bijlenga, Philippe, Corniola, Marco, Schaller, Karl, Chicherio, Christian, Seule, Martin A, Ferrari, Andrea, Weyerbrock, Astrid, Hlavica, Martin, Fournier, Jean-Yves, Früh, Severin, Schatlo, Bawarjan, Burkhardt, Jan-Karl, Stienen, Martin N, Keller, Emanuela, Regli, Luca, Bozinov, Oliver, Maldaner, Nicolai, Finkenstädt, Sina, Neidert, Marian C, Brugger, Peter, and Mondadori, Christian
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- 2018
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9. Development of a Complication- and Treatment-Aware Prediction Model for Favorable Functional Outcome in Aneurysmal Subarachnoid Hemorrhage Based on Machine Learning
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Maldaner, Nicolai, Zeitlberger, Anna M, Sosnova, Marketa, Goldberg, Johannes, Fung, Christian, Bervini, David, May, Adrien, Bijlenga, Philippe, Schaller, Karl, Roethlisberger, Michel, Rychen, Jonathan, Zumofen, Daniel W, D’Alonzo, Donato, Marbacher, Serge, Fandino, Javier, Daniel, Roy Thomas, Burkhardt, Jan-Karl, Chiappini, Alessio, Robert, Thomas, Schatlo, Bawarjan, Schmid, Josef, Maduri, Rodolfo, Staartjes, Victor E, Seule, Martin A, Weyerbrock, Astrid, Serra, Carlo, Stienen, Martin Nikolaus, Bozinov, Oliver, and Regli, Luca
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- 2021
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10. Development of a Complication- and Treatment-Aware Prediction Model for Favorable Functional Outcome in Aneurysmal Subarachnoid Hemorrhage Based on Machine Learning.
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Maldaner, Nicolai, Zeitlberger, Anna M, Sosnova, Marketa, Goldberg, Johannes, Fung, Christian, Bervini, David, May, Adrien, Bijlenga, Philippe, Schaller, Karl, Roethlisberger, Michel, Rychen, Jonathan, Zumofen, Daniel W, D'Alonzo, Donato, Marbacher, Serge, Fandino, Javier, Daniel, Roy Thomas, Burkhardt, Jan-Karl, Chiappini, Alessio, Robert, Thomas, Schatlo, Bawarjan, Schmid, Josef, Maduri, Rodolfo, Staartjes, Victor E, Seule, Martin A, Weyerbrock, Astrid, Serra, Carlo, Stienen, Martin Nikolaus, Bozinov, Oliver, and Regli, Luca
- Abstract
Current prognostic tools in aneurysmal subarachnoid hemorrhage (aSAH) are constrained by being primarily based on patient and disease characteristics on admission.
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- 2021
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11. Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage
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Schatlo, Bawarjan, Fung, Christian, Stienen, Martin N., Fathi, Ali R., Fandino, Javier, Smoll, Nicolas R., Zumofen, Daniel, Daniel, Roy Thomas, Burkhardt, Jan-Karl, Bervini, David, Marbacher, Serge, Reinert, Michael, D´Alonzo, Donato, Ahlborn, Peter, Mendes Pereira, Vitor, Roethlisberger, Michel, Seule, Martin, Kerkeni, Hassen, Remonda, Luca, Weyerbrock, Astrid, Woernle, Kerstin, Venier, Alice, Perren, Fabienne, Sailer, Martin, Robert, Thomas, Rohde, Veit, Schöni, Daniel, Goldberg, Johannes, Nevzati, Edin, Diepers, Michael, Gralla, Jan, Z’Graggen, Werner, Starnoni, Daniele, Woernle, Christoph, Maldaner, Nicolai, Kulcsar, Zsolt, Mostaguir, Khaled, Maduri, Rodolfo, Eisenring, Christian, Bernays, René, Ferrari, Andrea, Dan-Ura, Hiroki, Finkenstädt, Sina, Gasche, Yvan, Sarrafzadeh, Asita, Jakob, Stephan M., Corniola, Marco, Baumann, Fabian, Regli, Luca, Levivier, Marc, Hildebrandt, Gerhard, Landolt, Hans, Mariani, Luigi, Guzman, Raphael, Beck, Jürgen, Raabe, Andreas, Keller, Emanuela, Bijlenga, Philippe, and Schaller, Karl
- Abstract
Supplemental Digital Content is available in the text.
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- 2021
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12. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K., van der Spek, Rick A. A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L. M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Kim, Helen, Coleman, Jonathan R. I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J. M., Malik, Rainer, Dichgans, Martin, Sargurupremraj, Muralidharan, Tatlisumak, Turgut, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J. E., Worrall, Bradford B., Pera, Joanna, Slowik, Agnieszka, Gaál-Paavola, Emília I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Woo, Daniel, Redon, Richard, Bijlenga, Philippe, Kamatani, Yoichiro, Veldink, Jan H., and Ruigrok, Ynte M.
- Abstract
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.
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- 2020
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13. Radiomics approach to quantify shape irregularity from crowd-based qualitative assessment of intracranial aneurysms
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Juchler, Norman, Schilling, Sabine, Glüge, Stefan, Bijlenga, Philippe, Rüfenacht, Daniel, Kurtcuoglu, Vartan, and Hirsch, Sven
- Abstract
ABSTRACTThe morphological assessment of anatomical structures is clinically relevant, but often falls short of quantitative or standardised criteria. Whilst human observers are able to assess morphological characteristics qualitatively, the development of robust shape features remains challenging. In this study, we employ psychometric and radiomic methods to develop quantitative models of the perceived irregularity of intracranial aneurysms (IAs). First, we collect morphological characteristics (e.g. irregularity, asymmetry) in imaging-derived data and aggregated the data using rank-based analysis. Second, we compute regression models relating quantitative shape features to the aggregated qualitative ratings (ordinal or binary). We apply our method for quantifying perceived shape irregularity to a dataset of 134 IAs using a pool of 179 different shape indices. Ratings given by 39 participants show good agreement with the aggregated ratings (Spearman rank correlation ). The best-performing regression model based on quantitative shape features predicts the perceived irregularity with
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- 2020
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14. Comparison of statistical learning approaches for cerebral aneurysm rupture assessment
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Detmer, Felicitas J., Lückehe, Daniel, Mut, Fernando, Slawski, Martin, Hirsch, Sven, Bijlenga, Philippe, von Voigt, Gabriele, and Cebral, Juan R.
- Abstract
Purpose: Incidental aneurysms pose a challenge to physicians who need to decide whether or not to treat them. A statistical model could potentially support such treatment decisions. The aim of this study was to compare a previously developed aneurysm rupture logistic regression probability model (LRM) to other machine learning (ML) classifiers for discrimination of aneurysm rupture status. Methods: Hemodynamic, morphological, and patient-related information of 1631 cerebral aneurysms characterized by computational fluid dynamics simulations were used to train support vector machines (SVMs) with linear and RBF kernel (RBF-SVM), k-nearest neighbors (kNN), decision tree, random forest, and multilayer perceptron (MLP) neural network classifiers for predicting the aneurysm rupture status. The classifiers’ accuracy, sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were evaluated and compared to the LRM using 249 test cases obtained from two external cohorts. Additionally, important variables were determined based on the random forest and weights of the linear SVM. Results: The AUCs of the MLP, LRM, linear SVM, RBF-SVM, kNN, decision tree, and random forest were 0.83, 0.82, 0.80, 0.81, 0.76, 0.70, and 0.79, respectively. The accuracy ranged between 0.76 (decision tree,) and 0.79 (linear SVM, RBF-SVM, and MLP). Important variables for predicting the aneurysm rupture status included aneurysm location, the mean surface curvature, and maximum flow velocity. Conclusion: The performance of the LRM was overall comparable to that of the other ML classifiers, confirming its potential for aneurysm rupture assessment. To further improve the predictions, additional information, e.g., related to the aneurysm wall, might be needed.
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- 2020
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15. Mixed reality-guided glioblastoma resection compared to standard procedures: assessing the surgical and clinical benefits of the virtual world in tumor surgery
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Haemmerli, Julien, Khatchatourov, Samuel, Chaboudez, Etienne, Sandralegar, Abiram, Schaller, Karl, and Bijlenga, Philippe
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- 2024
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16. Impact of Aneurysm Multiplicity on Treatment and Outcome After Aneurysmal Subarachnoid Hemorrhage
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Roethlisberger, Michel, Achermann, Rita, Bawarjan, Schatlo, Stienen, Martin N, Fung, Christian, D’Alonzo, Donato, Maldaner, Nicolai, Ferrari, Andrea, Corniola, Marco V, Schöni, Daniel, Goldberg, Johannes, Valsecchi, Daniele, Robert, Thomas, Maduri, Rodolfo, Seule, Martin A, Burkhardt, Jan-Karl, Marbacher, Serge, Bijlenga, Philippe, Blackham, Kristine A, Bucher, Heiner C, Mariani, Luigi, Guzman, Raphael, and Zumofen, Daniel W
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- 2019
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17. Correlating Clinical Risk Factors and Histological Features in Ruptured and Unruptured Human Intracranial Aneurysms: The Swiss AneuX Study.
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Morel, Sandrine, Diagbouga, Mannekomba R, Dupuy, Nicolas, Sutter, Esther, Braunersreuther, Vincent, Pelli, Graziano, Corniola, Marco, Gondar, Renato, Jägersberg, Max, Isidor, Nathalie, Schaller, Karl, Bochaton-Piallat, Marie-Luce, Bijlenga, Philippe, and Kwak, Brenda R
- Abstract
Pathogenesis of intracranial aneurysm is complex and the precise biomechanical processes leading to their rupture are uncertain. The goal of our study was to characterize the aneurysmal wall histologically and to correlate histological characteristics with clinical and radiological factors used to estimate the risk of rupture. A new biobank of aneurysm domes resected at the Geneva University Hospitals (Switzerland) was used. Histological analysis revealed that unruptured aneurysms have a higher smooth muscle cell (SMC) content and a lower macrophage content than ruptured domes. These differences were associated with more collagen in unruptured samples, whereas the elastin content was not affected. Collagen content and type distribution were different between thick and thin walls of unruptured aneurysms. Classification of aneurysm domes based on histological characteristics showed that unruptured samples present organized wall rich in endothelial and SMCs compared with ruptured samples. Finally, aneurysm wall composition was altered in unruptured domes of patients presenting specific clinical factors used to predict rupture such as large dome diameter, dome irregularities, and smoking. Our study shows that the wall of aneurysm suspected to be at risk for rupture undergoes structural alterations relatively well associated with clinical and radiological factors currently used to predict this risk.
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- 2018
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18. Trans-venous embolization of a basal ganglia ruptured arteriovenous malformation with open surgical arterial control: A hybrid technique
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Kulcsár, Zsolt, Machi, Paolo, Schaller, Karl, Lovblad, Karl Olof, and Bijlenga, Philippe
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Treatment of ruptured deep-seated arteriovenous malformations is challenging and associated with elevated risks. This is due to the proximity or involvement of critical brain structures and the specifically fine and delicate angioarchitecture of these lesions, making both endovascular and surgical access technically complicated. We present the advantages of a true combined, open surgical and endovascular transvenous approach in a hybrid operating room. The technique may overcome in part the difficulties and may improve safety and risk related concerns.
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- 2018
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19. Predictors of In-Hospital Death After Aneurysmal Subarachnoid Hemorrhage
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Stienen, Martin Nikolaus, Germans, Menno, Burkhardt, Jan-Karl, Neidert, Marian C., Fung, Christian, Bervini, David, Zumofen, Daniel, Röthlisberger, Michel, Marbacher, Serge, Maduri, Rodolfo, Robert, Thomas, Seule, Martin A., Bijlenga, Philippe, Schaller, Karl, Fandino, Javier, Smoll, Nicolas R., Maldaner, Nicolai, Finkenstädt, Sina, Esposito, Giuseppe, Schatlo, Bawarjan, Keller, Emanuela, Bozinov, Oliver, Regli, Luca, Serra, Carlo, Krayenbühl, Niklaus, Schöni, Daniel, Raabe, Andreas, Beck, Jürgen, Goldberg, Johannes, Mariani, Luigi, Guzman, Raphael, D’Alonzo, Donato, Coluccia, Daniel, Daniel, Roy Thomas, Starnoni, Daniele, Messerer, Mahmoud, Levivier, Marc, Valsecchi, Daniele, Arrighi, Marta, Venier, Alice, Reinert, Michael, Kuhlen, Dominique Emmanuelle, Ferrari, Andrea, Weyerbrock, Astrid, Hildebrandt, Gerhard, Hlavica, Martin, Fournier, Jean-Yves, and Corniola, Marco
- Abstract
Supplemental Digital Content is available in the text.
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- 2018
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20. PHASES Score for the Management of Intracranial Aneurysm
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Bijlenga, Philippe, Gondar, Renato, Schilling, Sabine, Morel, Sandrine, Hirsch, Sven, Cuony, Johanna, Corniola, Marco-Vincenzo, Perren, Fabienne, Rüfenacht, Daniel, and Schaller, Karl
- Abstract
Supplemental Digital Content is available in the text.
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- 2017
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21. 135 Real-World Data of Microvascular Decompression in Trigeminal Neuralgia: Analysis of 26 Tertiary Care Centers of the European Continent
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Sommer, Björn, Shiban, Ehab, Schatlo, Bawarjan, Rohde, Veit, Thomé, Claudius, Brito Silva Barbosa, Marcos Daniel, Jödicke, Andreas, Gandía González, Maria Luisa, Blasco, Guillermo, Demetriades, Andreas K., Sure, Ulrich, Vanaclocha, Vincente, Mastronardi, Luciano, Ringel, Florian, Gonzalez-Lopez; Peter Vajkoczy, Pablo, Ruiz-Juretschke, Fernando, Stummer, Walter, Sames, Martin, Fedirko, Volodymyr, Bijlenga, Philippe A., Seifert, Volker, Meyer, Bernhard, and Lehmberg, Jens
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- 2023
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22. Risk of Rupture of Small Anterior Communicating Artery Aneurysms Is Similar to Posterior Circulation Aneurysms
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Bijlenga, Philippe, Ebeling, Christian, Jaegersberg, Max, Summers, Paul, Rogers, Alister, Waterworth, Alan, Iavindrasana, Jimison, Macho, Juan, Pereira, Vitor Mendes, Bukovics, Peter, Vivas, Elio, Sturkenboom, Miriam C.J.M., Wright, Jessica, Friedrich, Christoph M., Frangi, Alejandro, Byrne, James, Schaller, Karl, Rufenacht, Daniel, Narata, Ana Paula, Clarke, Alison, Yarnold, Julia, Kover, Ferenc, Schatlo, Bawarjan, Hudak, Stephan, Teta, Patrick, Blasco, Jordi, Gonzalez, Ana Marcos, Lovblad, Karl-Olof, Coley, Stuart, Dòczi, Tamas, Risselada, Roelof, Sola, Theresa, Lawford, Patricia, Patel, Umang, Singh, Pankaj, Wickins, Jeremy, Elger, Bernice, Beyleveld, Derick, Wood, Steven, Hasselmeyer, Peer, Arbona, Antonio, Meyer, Rodolphe, Hose, Rod, Lonsdale, Guy, Hofmann-Apitius, Martin, Frangi, Alejandro, Bijlenga, Philippe, Hofmann-Apitius, Martin, Hose, Rod, Lonsdale, Guy, Arbona, Antonio, Hasselmeyer, Peer, Rüfenacht, Daniel, Bijlenga, Philippe, Summers, Paul, Jägersberg, Max, Rogers, Alister, Schaller, Karl, Byrne, James, Wright, Jessica, Wilkins, Jeremy, Beyleveld, Derick, Elger, Bernice, Waterworth, Alan, Wood, Steven, Iavindrasana, Jimison, Meyer, Rodolphe, Friedrich, Christoph, Ebeling, Christian, Ebeling, Christian, Bijlenga, Philippe, Risselada, Roelof, Friedrich, Christoph, Sturkenboom, Miriam CJM, Bijlenga, Philippe, Jägersberg, Max, Rogers, Alister, Schatlo, Bawarjan, Teta, Patrick, Schaller, Karl, Mendes-Pereira, Vitor, Gonzalez, Ana Marcos, Narata, Ana Paula, Lovblad, Karl O, Rüfenacht, Daniel A., Yarnold, Julia, Summers, Paul, Clarke, Alison, Zilani, Gulam, Byrne, James, Macho, Juan, Blasco, Jordi, Bukovics, Peter, Kover, Ferenc, Hudak, Istvan, Doczi, Tamas, Risselada, Roelof, Sturkenboom, Miriam CJM, Singh, Pankaj, Waterworth, Alan, Patel, Umang, Coley, Stuart, Lawford, Patricia, Sola, Teresa, and Vivas, Elio
- Abstract
According to the International Study of Unruptured Intracranial Aneurysms (ISUIA), anterior circulation (AC) aneurysms of <7 mm in diameter have a minimal risk of rupture. It is general experience, however, that anterior communicating artery (AcoA) aneurysms are frequent and mostly rupture at <7 mm. The aim of the study was to assess whether AcoA aneurysms behave differently from other AC aneurysms.
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- 2013
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23. Comparison Between Augmented Reality-Based and Ex-Cathedra Lectures: Can We Improve The Education of Neuroanatomy with The Use of Novel Technologies?
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Sandralegar, Abiram, Bernard, Florian, Schaller, Karl, Bijlenga, Philippe, and Haemmerli, Julien
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- 2023
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24. Impact of acute hydrocephalus after aneurysmal SAH on longitudinal neuropsychological outcome
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Maschke, Svenja, Germans, Menno, Bijlenga, Philippe, Maduri, Rodolfo, Daniel, R.T., Chiappini, Alessio, Robert, Thomas, Zeitlberger, A.M., Goldberg, Johannes, Bervini, David, Bozinov, Oliver, Keller, Emanuela, Regli, Luca, Stienen, Martin, and Hostettler, I.C.
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- 2023
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25. Wall Shear Stress Distribution of Small Aneurysms Prone to Rupture
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Pereira, Vitor Mendes, Brina, Olivier, Bijlenga, Philippe, Bouillot, Pierre, Narata, Ana Paula, Schaller, Karl, Lovblad, Karl-Olof, and Ouared, Rafik
- Abstract
Subarachnoid hemorrhage after intracranial aneurysm rupture remains a serious condition. We performed a case–control study to evaluate the use of computed hemodynamics to detect cerebral aneurysms prone to rupture.
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- 2014
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26. EXPRESS: ESO guideline for the management of extracranial and intracranial artery dissection
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Debette, Stephanie, mazighi, Michael, Bijlenga, Philippe, Pezzini, Alessandro, Koga, Masatoshi, Bersano, Anna, Kõrv, Janika, Haemmerli, Julien, Canavero, Isabelle, Tekiela, Piotr, Miwa, Kaori, Seiffge, David, Schilling, Sabrina, Avtar, Lal, Arnold, Marcel, Markus, Hugh S., Engelter, Stefan T., and Majersik, Jennifer
- Abstract
The aim of the present European Stroke Organisation guideline is to provide clinically useful evidence-based recommendations on the management of extracranial artery dissection (EAD) and intracranial artery dissection (IAD). EAD and IAD represent leading causes of stroke in the young, but are uncommon in the general population, thus making it challenging to conduct clinical trials and large observational studies. The guidelines were prepared following the Standard Operational Procedure for European Stroke Organisation guidelines and according to GRADE methodology. Our four recommendations result from a thorough analysis of the literature comprising two randomized clinical trials (RCTs) comparing anticoagulants to anti-platelets in the acute phase of ischemic stroke and twenty-six comparative observational studies. In EAD patients with acute ischemic stroke we recommend using intravenous thrombolysis (IVT) with alteplase within 4.5 hours of onset if standard inclusion/exclusion criteria are met, and mechanical thrombectomy in patients with large vessel occlusion of the anterior circulation. We further recommend early endovascular or surgical intervention for IAD patients with subarachnoid hemorrhage (SAH). Based on evidence from two phase 2 RCTs that have shown no difference between the benefits and risks of anticoagulants versus anti-platelets in the acute phase of symptomatic EAD, we strongly recommend that clinicians can prescribe either option. In post-acute EAD patients with residual stenosis or dissecting aneurysms and in symptomatic IAD patients with an intracranial dissecting aneurysm and isolated headache, there is insufficient data to provide a recommendation on the benefits and risks of endovascular/surgical treatment. Finally, nine expert consensus statements, adopted by 8 to 11 of the 11 experts involved, propose guidance for clinicians when the quality of evidence was too low to provide recommendations. Some of these pertain to the management of IAD (use of IVT, endovascular treatment, and antiplatelets versus anticoagulation in IAD with ischemic stroke and use of endovascular or surgical interventions for IAD with headache only). Other expert consensus statements address the use of direct anticoagulants and dual antiplatelet therapy in EAD-related cerebral ischemia, endovascular treatment of the EAD/IAD lesion and multidisciplinary assessment of the best therapeutic approaches in specific situations.
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- 2021
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27. Mibefradil (Ro 40‐5967) inhibits several Ca2+and K+currents in human fusion‐competent myoblasts
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Liu, Jian‐Hui, Bijlenga, Philippe, Occhiodoro, Teresa, Fischer‐Lougheed, Jacqueline, Bader, Charles R, and Bernheim, Laurent
- Abstract
The effect of mibefradil (Ro 40–5967), an inhibitor of T‐type Ca2+current (ICa(T)), on myoblast fusion and on several voltage‐gated currents expressed by fusion‐competent myoblasts was examined.At a concentration of 5 μM, mibefradil decreases myoblast fusion by 57%. At this concentration, the peak amplitudes of ICa(T)and L‐type Ca2+current (ICa(L)) measured in fusion‐competent myoblasts are reduced by 95 and 80%, respectively. The IC50of mibefradil for ICa(T)and ICa(L)are 0.7 and 2 μM, respectively.At low concentrations, mibefradil increased the amplitude of ICa(L)with respect to control.Mibefradil blocked three voltage‐gated K+currents expressed by human fusion‐competent myoblasts: a delayed rectifier K+current, an ether‐à‐go‐goK+current, and an inward rectifier K+current, with a respective IC50of 0.3, 0.7 and 5.6 μM.It is concluded that mibefradil can interfere with myoblast fusion, a mechanism fundamental to muscle growth and repair, and that the interpretation of the effect of mibefradil in a given system should take into account the action of this drug on ionic currents other than Ca2+currents.
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- 1999
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28. Cloning of a human ether‐a‐go‐gopotassium channel expressed in myoblasts at the onset of fusion
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Occhiodoro, Teresa, Bernheim, Laurent, Liu, Jian-Hui, Bijlenga, Philippe, Sinnreich, Michael, Bader, Charles R, and Fischer-Lougheed, Jacqueline
- Abstract
An early sign of human myoblast commitment to fusion is the expression of a non‐inactivating delayed rectifier K+current, IK(NI), and an associated membrane potential hyperpolarization. We have isolated the full‐length coding region of a human ether‐a‐go‐goK+channel (h‐eag) from myoblasts undergoing differentiation. The h‐eaggene was localized to chromosome 1q32–41, and is expressed as a ∼9 kb transcript in myogenic cells and in adult brain tissue. Forced expression of h‐eagin undifferentiated myoblasts generates a current with remarkable similarity to IK(NI)indicating that h‐eagconstitutes the channel responsible for this current in vivo.
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- 1998
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29. Cloning of a human ether-a-go-gopotassium channel expressed in myoblasts at the onset of fusion
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Occhiodoro, Teresa, Bernheim, Laurent, Liu, Jian-Hui, Bijlenga, Philippe, Sinnreich, Michael, Bader, Charles R, and Fischer-Lougheed, Jacqueline
- Abstract
An early sign of human myoblast commitment to fusion is the expression of a non-inactivating delayed rectifier K +current, I K(NI), and an associated membrane potential hyperpolarization. We have isolated the full-length coding region of a human ether-a-go-goK +channel (h- eag) from myoblasts undergoing differentiation. The h- eaggene was localized to chromosome 1q32–41, and is expressed as a ∼9 kb transcript in myogenic cells and in adult brain tissue. Forced expression of h- eagin undifferentiated myoblasts generates a current with remarkable similarity to I K(NI)indicating that h- eagconstitutes the channel responsible for this current in vivo.
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- 1998
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30. An ether ‐à‐go‐goK+current, Ih‐eag, contributes to the hyperpolarization of human fusion‐competent myoblasts
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Bijlenga, Philippe, Occhiodoro, Teresa, Liu, Jian‐Hui, Bader, Charles R., Bernheim, Laurent, and Fischer‐Lougheed, Jacqueline
- Abstract
1Two early signs of human myoblast commitment to fusion are membrane potential hyperpolarization and concomitant expression of a non‐inactivating delayed rectifier K+current, IK(NI). This current closely resembles the outward K+current elicited by rat ether‐à‐go‐go(r‐eag) channels in its range of potential for activation and unitary conductance.2It is shown that activation kinetics of IK(NI), like those of r‐eag, depend on holding potential and on [Mg2+]o, and that IK(NI), like r‐eag, is reversibly inhibited by a rise in [Ca2+].3Forced expression of an isolated human ether‐à‐go‐goK+channel (h‐eag) cDNA in undifferentiated myoblasts generates single‐channel and whole‐cell currents with remarkable similarity to IK(NI).4h‐eagcurrent (Ih‐eag) is reversibly inhibited by a rise in [Ca2+]i, and the activation kinetics depend on holding potential and [Mg2+]o.5Forced expression of h‐eaghyperpolarizes undifferentiated myoblasts from −9 to −50 mV, the threshold for the activation of both Ih‐eagand IK(NI). Similarly, the higher the density of IK(NI), the more hyperpolarized the resting potential of fusion‐competent myoblasts.6It is concluded that h‐eagconstitutes the channel underlying IK(NI)and that it contributes to the hyperpolarization of fusion‐competent myoblasts. To our knowledge, this is the first demonstration of a physiological role for a mammalian eagK+channel.
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- 1998
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31. Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature*
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Boss, Olivier, Samec, Sonia, Kühne, Françoise, Bijlenga, Philippe, Assimacopoulos-Jeannet, Françoise, Seydoux, Josiane, Giacobino, Jean-Paul, and Muzzin, Patrick
- Abstract
A new member of the uncoupling protein (UCP) family called UCP3 has recently been cloned and shown to be highly expressed in skeletal muscle of rodents and humans. In the present study, UCP3 was overexpressed in C2C12myoblasts where it acts as an uncoupling protein. Changes in UCP3 mRNA expression were examined in rodent muscles under conditions known to modulate thermogenesis in brown adipose tissue. In skeletal muscle, UCP3 expression did not change in response to 48 h of cold exposure (6 °C), whereas it was decreased by 81% or increased 5.6-fold by 1 week of 50% food restriction or fasting, respectively. It was also decreased by 36% in soleus muscle of obese (fa/fa) as compared with lean Zucker rats. The unexpected rise of UCP3 mRNA level induced by fasting did not change in vitromuscle basal heat production rate but decreased by 31% the capacity to produce heat in response to the uncoupler carbonylcyanidep-trifluoromethoxyphenylhydrazone. This decrease may reflect underlying uncoupling by UCP3. Up-regulation of UCP3 mRNA after a 24-h fast was still observed in mice exposed at thermoneutrality. These results show that the increase in UCP3 expression induced by fasting is associated with the maintenance of thermogenesis measured in muscle in vitroand is not modulated by environmental temperature. The notion that UCP3 expression is modulated by food intake is of importance to better understand the pathophysiology of obesity in humans.
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- 1998
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32. Author Correction: Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors
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Bakker, Mark K., van der Spek, Rick A. A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L. M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Kim, Helen, Coleman, Jonathan R. I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J. M., Malik, Rainer, Dichgans, Martin, Sargurupremraj, Muralidharan, Tatlisumak, Turgut, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J. E., Worrall, Bradford B., Pera, Joanna, Slowik, Agnieszka, Gaál-Paavola, Emília I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Woo, Daniel, Redon, Richard, Bijlenga, Philippe, Kamatani, Yoichiro, Veldink, Jan H., and Ruigrok, Ynte M.
- Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2021
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