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1. Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes

Author

Wangchuk, Phurpa, Shepherd, Catherine, Constantinoiu, Constantin, Ryan, Rachael Y. M., Kouremenos, Konstantinos A., Becker, Luke, Jones, Linda, Buitrago, Geraldine, Giacomin, Paul, Wilson, David, Daly, Norelle, McConville, Malcolm J., Miles, John J., and Loukas, Alex

Abstract

Iatrogenic hookworm therapy shows promise for treating disorders that result from a dysregulated immune system, including inflammatory bowel disease (IBD). Using a murine model of trinitrobenzenesulfonic acid-induced colitis and human peripheral blood mononuclear cells, we demonstrated that low-molecular-weight metabolites derived from both somatic extracts (LMWM-SE) and excretory-secretory products (LMWM-ESP) of the hookworm, Ancylostoma caninum, display anti-inflammatory properties.

Published
2019
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