186 results on '"Ashraf, H."'
Search Results
2. Development of N-Terminally Modified Variants of the CXCR4-Antagonistic Peptide EPI-X4 for Enhanced Plasma Stability
- Author
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Harms, Mirja, Fabech Hansson, Rikke, Gilg, Andrea, Almeida-Hernández, Yasser, Löffler, Jessica, Rodríguez-Alfonso, Armando, Habib, Monica M. W., Albers, Dan, Ahmed, Nermin S., Abadi, Ashraf H., Winter, Gordon, Rasche, Volker, Beer, Ambros J., Weidinger, Gilbert, Preising, Nico, Ständker, Ludger, Wiese, Sebastian, Sanchez-Garcia, Elsa, Zelikin, Alexander N., and Münch, Jan
- Abstract
EPI-X4, a natural peptide CXCR4 antagonist, shows potential for treating inflammation and cancer, but its short plasma stability limits its clinical application. We aimed to improve the plasma stability of EPI-X4 analogues without compromising CXCR4 antagonism. Our findings revealed that only the peptide N-terminus is prone to degradation. Consequently, incorporating d-amino acids or acetyl groups in this region enhanced peptide stability in plasma. Notably, EPI-X4 leads 5, 27, and 28not only retained their CXCR4 binding and antagonism but also remained stable in plasma for over 8 h. Molecular dynamic simulations showed that these modified analogues bind similarly to CXCR4 as the original peptide. To further increase their systemic half-lives, we conjugated these stabilized analogues with large polymers and albumin binders. These advances highlight the potential of the optimized EPI-X4 analogues as promising CXCR4-targeted therapeutics and set the stage for more detailed preclinical assessments.
- Published
- 2023
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3. P4.04C.08 Sensitivity of Artificial Intelligence in Low-dose Computed Tomography Screening for Lung Cancer
- Author
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Mahovkic, A., Borgbjerg, J., Neumann, K., Strand, T.E., and Ashraf, H.
- Published
- 2024
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4. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De La Medina, Antonio, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, van Ramshorst, Gabrielle H, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Casteleins, William Augusto, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Martin, Janet, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Lee, Susan M, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Modolo, Maria Marta, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Olivos, Maricarmen, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Safi, Mohammed, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Christensen, Peter, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Asla, Amir Fathi, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Awad, Ahmed K, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Elbadawy, Merihan A, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Al-Mallah, Abdullah, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, Esmail, Eslam S, Hawila, Ahmed Maher, Hamada, Mohamed K, Motawea, Sara H, Morsy, Mohamed S, El-Sheemy, Hatem Refaat, Ebada, Mahmoud Ahmed, Khedr, Ali H, Gad, Ahmed, Elmandouh, Omar, Elmandouh, Reem, Alkanj, Souad, Youssef, Mohammad G, Awad, Kamal, Mohammed, Maged, Elsayad, Ahmed H, Rätsep, Tõnu, Wolle, Melatework A, Negussie, Abraham G, Adimass, Misganaw A, Misganaw, Bereket Tsegaye, Bezabih, Yoseph S, Assefa, Biniam Zemedu, Shumye, Getachew W, Mengesha, Mengistu G, Gechera, Dagnachew Y, Mohammed, Adnan A, Mulugeta, Gersam A, Metaferia, Yonas Y, Kifetew, Ashebir B, Degefa, Eyueal A, Deressa, Yadani M, Gonfa, Kebebe Bekele, Bedane, Zewdie G, Ayalew, Alem M, Ayele, Henok Teshome, Abebe, Engida, Worku, Bereket Atnafu, Sisay, Million M, Kassa, Dawit Worku, Awedew, Atalel F, Bayable, Abera C, Tiruneh, Abraham Genetu, Hailu, Samuel, Numaro, Yilkal T, Ademe, Yonas, Baleh, Abat S, Megerssa, Thomas B, Kejela, Segni, Derilo, Habtamu T, Akililu, Yemisirach B, Lebbe, Iris, Sarjanoja, Elise K, Kauppila, Joonas H, Sinikumpu, Juha-Jaakko, Giordano, Salvatore, Kantor, Elie, Soussan, Romy, Tommaso, Cipolat Mis, Nappi, Francesco, Morichau-Beauchant, Tristan, Nahum, Julien, Maillet, Jean-Michel, Godement, Mathieu, Jouffret, Lionel, Migliorelli, Federico, De Simone, Belinda, Brunaud, Laurent, Fuchs-Buder, Thomas, Testelin, Sylvie, Bin, Kim, Boucher, Sophie, Schmitt, Françoise, Lakkis, Zaher, Harper, Luke, Slim, K, Piessen, Guilaume, Eveno, Clarisse, Ballouhey, Quentin, Taibi, Abdelkader, Crenn, Vincent, Duchalais, Emilie, Arnaud, Alexis P, Azzis, Olivier, Tuech, Jean-Jacques, Vaysse, Charlotte, Weyl, Ariane, Vergriete, Kelig, Charbonneau, Helene, Ezanno, Anne-Cecile, Malgras, Brice, Basso, Celeste Del, Duquesne, Igor, Bernabei, Federico, Rothschild, Pierre-Raphaël, Abbo, Olivier, Manceau, Gilles, Chamouni, Alexandre, Crétolle, Célia, Arnalsteen, Laurent, Mikhael, Elie, Police, Andrea, Montero-Macias, Rosa, Villefranque, Vincent, Maisonneuve, Emeline, Langlais, Tristan, Seeliger, Barbara, Pessaux, Patrick, Gonzalez, Cristians A, D'Urso, Antonio, Angeles, Martina A, Seguin-Givelet, Agathe, Des Deserts, Marc Danguy, Gaujoux, Sebastien, de Ponthaud, Charles, Chartier-Kastler, Emmanuel J, Ali, Liza, Peycelon, Matthieu, Mege, Diane, Demetrashvili, Zaza, Stoleriu, Mircea G, Keppler, Lena, Saier, Tim, Konrads, Christian, Tapking, Christian, Kamphues, Carsten, Bulian, Dirk R, Schmedding, Andrea, Doerner, Johannes, Gut, Anna E, Rolinger, Jens, Kirschniak, Andreas, Schröder, Lars, Reim, Daniel, Safi, Seyer, Fichter, Andreas M, Wagner, Arthur, Meyer, Bernhard, Gempt, Jens, Sablotzki, Armin R, Herzberg, Jonas, Altenburg, Manuel, Yenilmez, Ferhat, Meins, Jan, Aghwan, Louai A, 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Chamakhi, Amine, Sebai, Amine, dahman, Nesrine Ben hadj, Ammar, Houssem, Said, Mohamed Amine, Kechiche, Nahla, Aghayeva, Afag, Dülgeroğlu, Onur, Ozben, Volkan, Aytac, Erman, Atasoy, Deniz, Arikan, Akif Enes, Kara, Halil, Dogan, Nasuh U, Bostanci, Asli, Turhan, Murat, Ozkan, Ozlenen, Dumlu, Ersin G, Menekşe, Ebru, Oter, Volkan, Piskin, Erol, Hasirci, Ismail, Colakoglu, Muhammet Kadri, Bostanci, Erdal Birol, Ozgun, Yigit Mehmet, Girgin, Behic, Erel, Serap, Demirel, Sibel, Yanik, Özge, Gecim, Ibrahim Ethem, Koc, Mehmet Ali, Akyol, Cihangir, Güner, Volkan, Konca, Can, Batioğlu, Figen, Hakseven, Musluh, Toptas, Tayfun, Aydin, Yener, Ulas, Ali B, Ince, Ilker, Altinel, Yuksel, Demirgan, Serdar, Meric, Serhat, Sevdi, Mehmet Salih, Ercetin, Candas, Ferahman, Sina, Aydin, Husnu, Dural, Ahmet Cem, Sahbaz, Nuri A, Yalkin, Omer, Sen, Murat, Isik, Ozgen, Yilmazlar, Ahmet Tuncay, Bisgin, Tayfun, Yigit, Banu, Isik, Arda, Leventoglu, Sezai, bayhan, Hüseyin, Buldanli, Mehmet Z, Gultekin, Murat, Cennet, Omer, Unal, Ertekin U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Alshryda, Sattar, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Stewart, Grant D, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Sheth, Hemant D, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Caruana, Edward J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Sambhwani, Sharan H, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Ganau, Mario, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Lederhuber, Hans, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Drake, Thomas M, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Venn, Mary L, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Mohamed, Mazin, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Nour, Shahd, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Edwards, John G, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Athanasiou, Antonios, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Mahmud, Ayesha, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Goru, Poornanand, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, McClain, Craig D, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, 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Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
- Abstract
The 2015 LancetCommission on global surgery identified surgery and anaesthesia as indispensable parts of holistic health-care systems. However, COVID-19 exposed the fragility of planned surgical services around the world, which have also been neglected in pandemic recovery planning. This study aimed to develop and validate a novel index to support local elective surgical system strengthening and address growing backlogs.
- Published
- 2022
- Full Text
- View/download PDF
5. Natural killer cells that respond to human immunodeficiency virus type 1 (HIV-1) peptides are associated with control of HIV-1 infection
- Author
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Tiemessen, Caroline T., Shalekoff, Sharon, Meddows-Taylor, Stephen, Schramm, Diana B., Papathanasopoulos, Maria A., Gray, Glenda E., Sherman, Gayle G., Coovadia, Ashraf H., and Kuhn, Louise
- Subjects
HIV infection -- Development and progression ,HIV infection -- Research ,Killer cells -- Physiological aspects ,Killer cells -- Research ,Peptides -- Physiological aspects ,Peptides -- Research ,Immune response -- Research ,Health - Published
- 2010
6. Effect of CT screening on smoking habits at 1-year follow-up in the Danish Lung Cancer Screening Trial (DLCST)
- Author
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Ashraf, H., Tonnesen, P., holst Pedersen, J., Dirksen, A., Thorsen, H., and Dossing, M.
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Lung cancer -- Diagnosis ,Cancer -- Diagnosis ,Cancer -- Influence ,Smoking cessation programs -- Statistics ,Smoking cessation programs -- Research ,CT imaging -- Usage ,CT imaging -- Research ,Health - Published
- 2009
7. Novel Technique for Treatment of Foveoschisis Associated With Optic Disk Pits: Active Aspiration of Intraretinal Fluid
- Author
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El Rayes, Ehab N., Habib, Ahmed M., Soliman, Ashraf H., Ibrahim, Ola M., El Sawwah, Karim M. H., and Williams, George A.
- Abstract
Supplemental Digital Content is Available in the Text.
- Published
- 2022
- Full Text
- View/download PDF
8. Safety and efficacy of diclofenac ophthalmic solution in the treatment of corneal abrasions
- Author
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Szucs, Paul A., Nashed, Ashraf H., Allegra, John R., and Eskin, Barnet
- Subjects
Glaucoma -- Care and treatment ,Glaucoma -- Health aspects ,Analgesics -- Health aspects ,Abrasions -- Care and treatment ,Abrasions -- Health aspects ,Ophthalmic drugs -- Health aspects ,Pain -- Care and treatment ,Pain -- Health aspects ,Health - Abstract
Byline: Paul A. Szucs, Ashraf H. Nashed, John R. Allegra, Barnet Eskin Abstract: Study objective: To determine whether the use of diclofenac ophthalmic solution is a safe and effective analgesic in the treatment of traumatic corneal abrasions in the emergency department. Methods: We conducted a prospective, randomized, double-blinded, placebo-controlled clinical trial. Consenting consecutive patients with corneal abrasions who presented to a community-based ED from August through February 1998 were randomly assigned to receive either diclofenac or control vehicle drops. Pain relief was measured using a visual Numeric Pain Intensity Scale (NPIS) before and after treatment. Exclusion criteria were as follows: age younger than 18 years, pregnancy, history of glaucoma, ocular infection, recent eye surgery, other signs of ocular trauma, narcotics within 6 hours, minimal pain (NPIS score Author Affiliation: Department of Emergency Medicine, Morristown Memorial Hospital, Morristown, NJ. Article History: Received 11 January 1999; Revised 28 October 1999; Accepted 15 November 1999 Article Note: (footnote) [star] Address for reprints: Paul A. Szucs, MD, Department of Emergency Medicine, Morristown Memorial Hospital, Box 8, 100 Madison Avenue, Morristown, NJ 07962; 973-971-8919, fax 973-290-7202; E-mail Paszooks@aol.com.
- Published
- 2000
9. Fibrinolytic therapy in young women with acute myocardial infarction
- Author
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Gard, Sangeeta, Nashed, Ashraf H., and Roche, Lisa M.
- Subjects
Emergency medicine ,Public health ,Heart attack ,Young women ,Cardiovascular agents ,Health - Abstract
Byline: Sangeeta Gard, Ashraf H Nashed, Lisa M Roche Abstract: Study objective: Previous studies found that women with acute myocardial infarction (AMI) receive less aggressive therapy compared with men. We sought to determine the percentage of young women ([less than or equal to]50 years) with an AMI eligible for fibrinolytic therapy who received it and explore factors resulting in the ineligibility of women for fibrinolytic therapy. Methods: A retrospective chart review was conducted for women 50 years of age or younger who were discharged from a tertiary cardiac care hospital with a diagnosis of AMI during the period 1990 to 1995. Women were included if they met the World Health Organization criteria for AMI. Results: There were 126 women meeting inclusion criteria with 54 (43%) receiving fibrinolytic therapy. Sufficient information to determine eligibility for fibrinolytic therapy was available for 118 (94%) of the women. Forty-one (91%) of the 45 women who met eligibility criteria received fibrinolytic therapy. Of the 73 women who were ineligible for fibrinolytic therapy, 52 (71%) had a nondiagnostic ECG, 28 (38%) presented 12 hours after symptom onset, and 19 (26%) had an absolute or relative contraindication to fibrinolytic therapy. Of the women not meeting eligibility requirements, 15% nonetheless received fibrinolytic therapy. Conclusion: In this study, most young women with AMI who were eligible for fibrinolytic therapy received it. Nondiagnostic ECG and late presentation to the emergency department (>12 hours after symptom onset) were the most common reasons for ineligibility. Author Affiliation: (1) Department of Emergency Medicine, Morristown Memorial Hospital, Morristown, NJ. USA Article History: Received 23 March 1998; Revised 6 November 1998; Accepted 17 March 1999 Article Note: (footnote) * Presented at the Society for Academic Emergency Medicine Annual Meeting, Washington DC, May 1997., ** Supported in part by the Emergency Medical Associates Research Foundation.
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- 1999
10. From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity
- Author
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Abdel-Halim, Mohammad, Sigler, Sara, Racheed, Nora A. S., Hefnawy, Amr, Fathalla, Reem K., Hammam, Mennatallah A., Maher, Ahmed, Maxuitenko, Yulia, Keeton, Adam B., Hartmann, Rolf W., Engel, Matthias, Piazza, Gary A., and Abadi, Ashraf H.
- Abstract
A ligand-based approach involving systematic modifications of a trisubstituted pyrazoline scaffold derived from the COX2 inhibitor, celecoxib, was used to develop novel PDE5 inhibitors. Novel pyrazolines were identified with potent PDE5 inhibitory activity lacking COX2 inhibitory activity. Compound d12was the most potent with an IC50of 1 nM, which was three times more potent than sildenafil and more selective with a selectivity index of >10,000-fold against all other PDE isozymes. Sildenafil inhibited the full-length and catalytic fragment of PDE5, while compound d12only inhibited the full-length enzyme, suggesting a mechanism of enzyme inhibition distinct from sildenafil. The PDE5 inhibitory activity of compound d12was confirmed in cells using a cGMP biosensor assay. Oral administration of compound d12achieved plasma levels >1000-fold higher than IC50values and showed no discernable toxicity after repeated dosing. These results reveal a novel strategy to inhibit PDE5 with unprecedented potency and isozyme selectivity.
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- 2021
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11. Diagnosis of Primary Aldosteronism by Seated Saline Suppression Test—Variability Between Immunoassay and HPLC-MS/MS
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Thuzar, Moe, Young, Karen, Ahmed, Ashraf H, Ward, Greg, Wolley, Martin, Guo, Zeng, Gordon, Richard D, McWhinney, Brett C, Ungerer, Jacobus P, and Stowasser, Michael
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- 2020
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12. Dam break analysis of Old Aswan Dam on Nile River using HEC-RAS
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Helwa, Amira M., Elgamal, Mohamed H., and Ghanem, Ashraf H.
- Abstract
The Egyptian segment of the Nile River is controlled from its upstream end by two dams: the High Aswan Dam (HAD) and the Old Aswan Dam (OAD). Nowadays, questions are being raised about the efficiency and safety of the Old Aswan Dam and what will happen if the dam fails? For this regard, a 1D hydraulic model using HEC-RAS package was developed to investigate a number of dam break scenarios, to estimate the outlet hydrograph from the dam site and to route the produced flood wave throughout the first river reach from the dam site up to Esna barrage. A numerical sensitivity analysis was performed to select the relevant values of the implicit weighting factor θ, Δx and Δt. Eight dam break scenarios were developed to investigate the effect of initial water level, inlet flow and dam breach width on the expected inundated area. Results showed that there would not be catastrophic consequences from the Old Aswan Dam failure. The main concern is when large flow values are released deliberately (Q = 605 mm3/sec) from the Aswan Dam.
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- 2020
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13. Large intra-pericardial sarcoma arising from ascending aorta--a case report
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Ashraf, H. Zubair, Qadri, S. Asrar, Ahangar, A. Ghani, Sharma, M. Lal, Dar, A. Majeed, Bhat, M. Akbar, and Dar, Farooq A.
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Pericardial effusion -- Diagnosis ,Pericardial effusion -- Case studies ,Thoracic tumors -- Diagnosis ,Thoracic tumors -- Care and treatment ,Thoracic tumors -- Patient outcomes ,Thoracic tumors -- Case studies ,Health - Abstract
A young male of 18 years admitted with a 1-week history of retrosternal discomfort, cough and exertional breathlessness and a 3-month history of anorexia and weight loss was found to have a large sarcoma arising from the intrapericardial ascending aorta. Surgery was performed by median sternotomy with complete excision. Histo-pathological examination revealed features of sarcoma. Intra-pericardial tumors arising from the ascending aorta are very rare and only five cases have been reported so far., Introduction Primary tumors of the aorta are very rare and correct preoperative diagnosis is uncommon. There are only 35 to 40 cases of primary aortic tumors reported in the literature [...]
- Published
- 2009
14. Existence and uniqueness of solutions to nonlocal-impulsive fractional Cauchy semilinear conformable differential equations
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Herzallah, Mohamed A. E. and Radwan, Ashraf H. A.
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AbstractThis paper is devoted to study the existence and uniqueness of solutions to fractional semilinear differential equations with conformable fractional derivative. We prove our results for local and nonlocal-impulsive conditions. This will be accomplished by using Schaefer’s fixed-point theorem and Banach’s fixed-point principle. Some examples are given to illustrate the main theorems.
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- 2019
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15. A cryptosystem based on chaotic maps and factoring problems
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Tahat, Nedal, Ismail, Eddie Shahril, and Aljammal, Ashraf H.
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A cryptosystem allows a sender to send any confidential or private message using a receiver's public key and the receiver next confirms the integrity and validity of the received message using his own secret key. Cryptosystem algorithms can be categorised based on the type of security suppositions, for example discrete logarithm, factorisation, and elliptic curve hard problems, which are all currently believed to be unsolvable in a reasonable time of period. Recently, cryptosystems based on chaotic maps have been proposed. Due to some subtle and close relationship between the properties of traditional cryptosystems and chaotic-based systems, the idea of using chaotic in cryptography has received a great deal of attention from many cryptography's researchers. Therefore, to enhance system security, we explore the implementation of a cryptosystem algorithm based on both cryptographic and chaotic system characteristics. We also provide security against known cryptographic attacks and discuss the performance analysis of the developed system.
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- 2019
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16. Reply
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El Rayes, Ehab N., Habib, Ahmed M., Soliman, Ashraf H., Ibrahim, Ola M., and El Sawwah, Karim M. H.
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- 2023
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17. Aldosterone LC-MS/MS Assay-Specific Threshold Values in Screening and Confirmatory Testing for Primary Aldosteronism.
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Guo, Zeng, Poglitsch, Marko, McWhinney, Brett C, Ungerer, Jacobus P J, Ahmed, Ashraf H, Gordon, Richard D, Wolley, Martin, and Stowasser, Michael
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Current threshold values for primary aldosteronism (PA) diagnostic testing are based on measuring aldosterone (PAC) using immunoassays. Quantification of PAC by liquid chromatography-tandem mass spectrometry (LC-MS/MS) yields lower values.
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- 2018
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18. Comparison of Seated With Recumbent Saline Suppression Testing for the Diagnosis of Primary Aldosteronism.
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Stowasser, Michael, Ahmed, Ashraf H, Cowley, Diane, Wolley, Martin, Guo, Zeng, McWhinney, Brett C, Ungerer, Jacobus P, and Gordon, Richard D
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Failure of plasma aldosterone suppression during fludrocortisone suppression testing (FST) or saline suppression testing (SST) confirms primary aldosteronism (PA). Aldosterone is often higher upright than recumbent in PA; upright levels are used during FST. In a pilot study (24 patients with PA), seated saline suppression testing (SSST) was more sensitive than recumbent saline suppression testing (RSST).
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- 2018
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19. Community Acquired Acute Kidney Injury in Mansoura Nephrology Dialysis Unit: One Year Prospective Observational Study
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Abdelsalam, Mostafa, Elnagar, Sherouk Salah Eldin, Mohamed, Ashraf H., Tawfik, Mona, and Sayed Ahmed, Nagy
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Aim:Acute kidney injury (AKI) is a major health problem with poor patient prognosis. We evaluated the clinical characteristics, risk factors, associated comorbidities, and outcomes of AKI patients. Methodology:A single-center prospective observational study. The patients were admitted in Mansoura Nephrology and Dialysis Unit over a period of 1 year from January to December, 2016. Patients were diagnosed as AKI or AKI in addition to chronic kidney disease according to the creatinine criteria of KDIGO 2013. All patients were subjected to complete history taking, physical examination, and full laboratory and pelvi-abdominal ultrasound investigations. The study outcomes were all-cause hospital mortality, and recovery of renal function. Predictors of mortality were assessed using multivariate logistic regression analysis. The study was reviewed and approved by local Ethical Committee of IBR. Results:We evaluated 199 (96 males plus 103 females) aged between 18 and 88 years old. Dehydration was the commonest precipitating factor for AKI in our patients (68.8%) and Oliguria was the commonest symptom present in 47.7% of patients. Intravenous fluids were received by 79.9% of patients, 22.6% of patients received diuretics, and 33.7% received renal replacement therapy in the form of intermittent hemodialysis. Death occurred in 25 patients (13.16%) and 69 (36.32%) showed no renal recovery. Shock and sepsis were the most significant predictors of mortality. Conclusion:Community acquired AKI is a major health problem with high morbidity and mortality.
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- 2018
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20. Analysis of the peristaltic-ciliary flow of Johnson–Segalman fluid induced by peristalsis-cilia of the human fallopian tube.
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Ashraf, H., Siddiqui, A.M., and Rana, M.A.
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- *
PERISTALSIS , *FALLOPIAN tubes , *MEAN volume rate (Chemistry) , *WAVELENGTHS , *NUMERICAL integration - Abstract
The present prospective theoretical analysis concerns with the peristalsis-cilia induced transport of a developing embryo from ampulla to intramural, in the human fallopian tube. A model of peristalsis-cilia induced flow of the Johnson–Segalman fluid within fallopian tubal fluid in a finite two dimensional narrow tube is developed. We solved highly non-linear PDE emerging from the modeling of proposed model using perturbation method. The series expressions for flow variables like axial and radial velocities, pressure gradient, stream function, volume flow rate and time mean volume flow rate are derived. The numerical integration is performed for appropriate residue time over tube length and pressure difference over wavelength. The analysis delineated that, involved parameters and constants have vice versa effects on axial velocity and appropriate residue time over tube length. Striking features of the pumping characteristics and the trapping phenomenon are discussed in detail. Furthermore, comparison of the peristaltic flow with the peristaltic-ciliary flow and Johnson–Segalman fluid with the linearly viscous fluid is made. It is revealed that appropriate residue time of the Johnson–Segalman fluid in the narrow tube is 3–4 days, which agreed with the time taken by the developing embryo from ampulla to intramural, in the human fallopian tube. [ABSTRACT FROM AUTHOR]
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- 2018
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21. Fallopian tube analysis of the peristaltic-ciliary flow of third grade fluid in a finite narrow tube
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Ashraf, H., Siddiqui, A.M., and Rana, M.A.
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•The peristaltic-ciliary flow of third grade fluid in a finite tube is analyzed.•Non-linear partial differential equation is solved using perturbation method.•Transport characteristics of embryo are better described by the third grade fluid.•Appropriate residue time is required to complete the mitotic divisions properly.
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- 2018
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22. A new technique for data encryption based on third party encryption server to maintain the privacy preserving in the cloud environment
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Aljammal, Ashraf H., Bani-Salameh, Hani, Qawasmeh, Ahmad, Alsarhan, Ayoub, and Otoom, Ahmed Fawzi
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As the cloud datacentres are exposed to various types of attacks, data theft/leakage is considered one of the vital attacks that may affect datacentres credibility. In this paper, a new technique is proposed to store the user's data in an encrypted form in the cloud datacentre via a third party encryption server. Therefore, the attackers and the datacentre authorities will be able to deal only with an encrypted form of the data. Furthermore, to decrypt the data, they need to know the encryption algorithm as well as the encryption key which is in turn placed on a third party encryption server. In addition, using third party encryption server (TPED) will lead to reducing the workload on both the cloud servers and the data owner's machine.
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- 2018
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23. Vasopressin Expressed in Hypothalamic CRF Neurons Causes Impaired Water Diuresis in Secondary Adrenal Insufficiency
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Yamagata, Satoshi, Talukder, Ashraf H, Murasawa, Shingo, Niioka, Kanako, Kumagai, Naoya, Takagi, Mao, Kawamura, Meiko, Natsume, Rie, Abe, Manabu, Uchida, Katsuya, Sato, Tatsuya, Kurose, Akira, Kageyama, Kazunori, Daimon, Makoto, Sakimura, Kenji, and Itoi, Keiichi
- Abstract
Patients with secondary adrenal insufficiency can present with impaired free water excretion and hyponatremia, which is due to the enhanced secretion of vasopressin (AVP) despite increased total body water. AVP is produced in magnocellular neurons in the paraventricular nucleus of the hypothalamus (PVH) and supraoptic nucleus and in parvocellular corticotropin-releasing factor (CRF) neurons in the PVH. This study aimed to elucidate whether magnocellular AVP neurons or parvocellular CRF neurons coexpressing AVP are responsible for the pathogenesis of hyponatremia in secondary adrenal insufficiency. The number of CRF neurons expressing copeptin, an AVPgene product, was significantly higher in adrenalectomized AVP-floxed mice (AVPfl/fl) than in sham-operated controls. Adrenalectomized AVPfl/flmice supplemented with aldosterone showed impaired water diuresis under ad libitum access to water or after acute water loading. They became hyponatremic after acute water loading, and it was revealed under such conditions that aquaporin-2 (AQP2) protein levels were increased in the kidney. Furthermore, translocation of AQP2 to the apical membrane was markedly enhanced in renal collecting duct epithelial cells. Remarkably, all these abnormalities observed in the mouse model for secondary adrenal insufficiency were ameliorated in CRF-AVP−/−mice that lacked AVP in CRF neurons. Our study demonstrates that CRF neurons in the PVH are responsible for the pathogenesis of impaired water excretion in secondary adrenal insufficiency.
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- 2023
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24. Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women
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Ahmed, Ashraf H., Gordon, Richard D., Ward, Gregory, Wolley, Martin, McWhinney, Brett C., Ungerer, Jacobus P., and Stowasser, Michael
- Abstract
Combined hormonal replacement therapy appears to be associated with a higher risk for false-positive results in screening for primary aldosteronism.
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- 2017
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25. Effect of Moxonidine on the Aldosterone/Renin Ratio in Healthy Male Volunteers.
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Ahmed, Ashraf H, Gordon, Richard D, Ward, Gregory, Wolley, Martin, McWhinney, Brett C, Ungerer, Jacobus P, and Stowasser, Michael
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The most popular screening test for primary aldosteronism is the plasma aldosterone/renin ratio (ARR). Medications, dietary sodium, posture, and time of day all affect renin and aldosterone levels and can result in false-negative or false-positive ARRs if not controlled. Most antihypertensive medications affect the ARR and can interfere with interpretation of results. To our knowledge, no study has been undertaken to evaluate the effects of moxonidine on the ARR.
- Published
- 2017
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26. A new architecture of cloud computing to enhance the load balancing
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Aljammal, Ashraf H., Manasrah, Ahmad M., Abdallah, Alaa E., and Tahat, Nedal M.
- Abstract
One of the emerging trends in IT environment is the cloud computing with various requirements and huge resources. Therefore, efficient load balancing guarantees an efficient resource utilisation to cope with the increasing users' demands. Consequently, this paper proposes a new architecture in a cloud environment for load balancing. The proposed architecture taking advantage of the client's machines resources for distributing the cloud tasks among the clients' machines rather than relying only on datacenters. The proposed architecture has been implemented using the cloudAnalyst simulator. The simulation results show an efficient load balancing through minimising the computational load on the cloud servers and hence, improve the overall cloud performance compared to the traditional architectures.
- Published
- 2017
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27. Tonsillar Kaposi sarcoma in a patient with membranous glomerulonephritis on immunosuppressive therapy
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Brahim, Nabeel Al-, Zaki, Ashraf H., Merhi, Khaled El-, and Ahmad, Mahmoud S.
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Kaposi's sarcoma -- Risk factors -- Diagnosis -- Case studies ,Glomerulonephritis -- Care and treatment -- Patient outcomes ,Immunosuppression -- Health aspects ,Health - Abstract
Kaposi sarcoma is a malignant vascular neoplasm uncommonly seen in immunosuppressed patients. Herein we report an unusual case of tonsillar Kaposi sarcoma in a patient with membranous glomerulonephritis treated with [...]
- Published
- 2013
28. Anti-reflux surgery in neonates and infants: analysis of indications, outcomes, and link to mortality among primary and secondary gastroesophageal reflux patients
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Mostafa, Ibrahim A., Hader, Hamad A., Khan, Safwan A., Hilal, Ahmed M., Gathradi, Mohamed A., and Ibrahim, Ashraf H. M.
- Abstract
Background: The indications and benefits of anti-reflux surgery (ARS) in neonates and infants are uncertain. Prematurity, operation before 1 year of age, neurological impairment (NI), and chronic lung disease (CLD) are risk factors for surgical failure. We aim to document the indications, management, and outcomes of ARS in this age group and compare them among primary and secondary gastroesophageal reflux (GERD). Results: Between January 2008 and December 2019, 24 males and 22 females had ARS; 13 (28.3%) for primary while 33 (71.7%) for secondary GERD. The mean gestational age was 34.6 weeks (range 24–41) and mean birth weight was 2000 gm (range 600–3300). The weight at time of referral ranged from 1.4 kg to 4 kg (mean 2.2 kg). There were no significant differences between the two groups regarding the previous data. The group of primary GERD presented mainly with recurrent aspiration (n= 8), recurrent apnea (n= 5), and recurrent desaturations with or shortly after feeds (n= 4). The group of secondary GERD were referred for poor sucking with failure to thrive (FTT) (n= 25), recurrent aspiration (n= 20), and gastrostomy request (n= 14). The risk factors for secondary GERD were neurologically impaired (n= 22), post-esophageal atresia (EA) repair (n= 9), hiatus hernia (n= 4), thoracic stomach (n= 2), N-type tracheoesophageal fistula (TEF, n= 4), and congenital esophageal stenosis (CES, n= 4). The operations included open Nissen’s fundoplication (ONF) (n= 4) and modified open Thal’s fundoplication (MOTF) (n= 42). There were 8 mortalities in the secondary group, unrelated to surgery. Morbidities after Nissen’s fundoplication included wrap migration, gas bloat, and reoperation in one, laparotomy for intestinal obstruction (IO) in one. Following MOTF, there were two cases of transient recurrent GERD which improved with time and laparotomy in one for IO. Conclusions: Diagnostic tests remain a challenge. Isolated TEF and CES may require fundoplication for staged management. Cases of the primary group did better with MTFO. Prematurity, CLD and age < 2 months were not significant risk factors for fundoplication failure or mortality. Neurological impairment was a risk factor for mortality.
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- 2022
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29. Gouty arthritis and kidney function outcomes and serum uric acid level variations in obese patients following bariatric surgery
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Balata, Mona G., Helal, Ahmed H., Mohamed, Ashraf H., Habib, Alaa-Uddin, Awad, Mahmoud, and Sherif, Mohamed
- Abstract
Background: Obesity is an independent risk factor for chronic kidney disease (CKD) and is the strongest known modifiable risk factor for hyperuricemia and gout. We aimed to discover the outcome of serum uric acid (SUA), gouty arthritis, and kidney function in obese patients after bariatric surgery and possible links with BMI variations. Methods: Retrospective study has been performed in National Hospital in Riyadh, KSA, between Jan. 2018 to Jan. 2020. We studied only 98 patients who met our inclusion criteria. Patients followed-up at 1 month (for gouty attack only) postoperative, 3 months postoperative, and 6 months postoperative for body mass index (BMI), serum creatinine, dipstick urinalysis, SUA, and estimated glomerular filtration rate (eGFR). Radiological studies, medical history, follow up radiological studies, and clinical follow up were obtained from the hospital data system. Results: A total of 98 patients with mean eGFR were 90.65 ± 29.34 ml/min/1.73 m
2 , mean SUA 5.56 ± 1.84 mg/dl, and mean BMI was 45.28 ± 7.25 kg/m2 , at surgery. Mean BMI had decreased significantly to 38.52 ± 6.05 kg/m2 at 3 months and to 34.61 ± 5.35 kg/m2 at 6 months (P< 0.001). The mean GFR had improved significantly (99.14 ± 23.32 ml/min/1.73 m2 ) at 6 months (P< 0.001). Interestingly, proteinuria had resolved in 17 patients out of 23 patients at 6 months. Number of gouty attacks was decreased during the first month post-surgery (P< 0.001). SUA level was significantly decreased (4.32 ± 1.27 mg/dl) (P< 0.001). SUA showed significant negative correlations with eGFR at 3 months and positively significant correlations with BMI at 3 and 6 months. By multinomial logistic regression, BMI and initial eGFR were the independent predictive variables for the outcome of eGFR at 6 months, while male gender and initial SUA were the independent predictive variables on the outcome of SUA at 6 months. Postoperatively in gouty arthritis patients, the number of joints affected, patient global VAS assessment, and number of gouty attacks were significantly reduced (P< 0.001). Conclusion: Bariatric surgery has been associated with reduction of BMI and subsequently reduction of SUA levels, gouty attacks, and improvement of eGFR.- Published
- 2022
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30. Treatment of Children With Scalds by Xenografts
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Elmasry, Moustafa, Steinvall, Ingrid, Thorfinn, Johan, Abbas, Ashraf H., Abdelrahman, Islam, Adly, Osama A., and Sjöberg, Folke
- Abstract
Scalds are the most common type of burn in children, and one way to treat them is with xenografts with no topical antimicrobials in line with the recommendations of a recent review. However, this treatment has not been examined in detail. Our aim was to describe the treatment of such children when biological dressings (xenografts) were used without local antimicrobials. We reviewed the medical records of all children admitted to a Swedish National Burn Centre during the period 2010–2012 with scalds who were treated with xenografts. Percentage TBSA injured, age, length of hospital stay, number of operations, antibiotics given, duration of antibiotic treatment, and pain score during the first 3 days, application of xenografts, and clinical notes of wound infection were recorded. We studied 67 children, (43 of whom were boys), with a median (interquartile range [IQR]) age of 1 (1–2) year and median (IQR) TBSA% 6.2 (4–11). Twenty children (30%) required operation. Twelve (18%) developed a wound infection, 29 (43%) had other infections, and 26 (39%) were free from infection. The median (IQR) duration of systemic antibiotics was 10 (6–13) days. On the day that the xenografts were applied 10 of the children had a Face, Legs, Activity, Cry, and Consolability (FLACC) score between 3 and 7, and during the following 2 days, only four children scored in this range. The remaining 57 children had scores < 3 on the day that xenografts were applied and on the following 2 days. Median (IQR) length of stay/TBSA% was 0.7 (0.4–1.0). Treatment with xenografts was associated with median length of stay/TBSA% <1 and low pain scores. Despite a high rate of prescription of systemic antibiotics, most were for reasons other than wound infection.
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- 2016
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31. Active control of nano dimers response using piezoelectric effect
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Campo, Eva M., Dobisz, Elizabeth A., Eldada, Louay A., Mekkawy, Ahmed A., Ali, Tamer A., and Badawi, Ashraf H.
- Published
- 2016
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32. A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences
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Thorgeirsson, T E, Steinberg, S, Reginsson, G W, Bjornsdottir, G, Rafnar, T, Jonsdottir, I, Helgadottir, A, Gretarsdottir, S, Helgadottir, H, Jonsson, S, Matthiasson, S E, Gislason, T, Tyrfingsson, T, Gudbjartsson, T, Isaksson, H J, Hardardottir, H, Sigvaldason, A, Kiemeney, L A, Haugen, A, Zienolddiny, S, Wolf, H J, Franklin, W A, Panadero, A, Mayordomo, J I, Hall, I P, Rönmark, E, Lundbäck, B, Dirksen, A, Ashraf, H, Pedersen, J H, Masson, G, Sulem, P, Thorsteinsdottir, U, Gudbjartsson, D F, and Stefansson, K
- Abstract
Using Icelandic whole-genome sequence data and an imputation approach we searched for rare sequence variants in CHRNA4 and tested them for association with nicotine dependence. We show that carriers of a rare missense variant (allele frequency=0.24%) within CHRNA4, encoding an R336C substitution, have greater risk of nicotine addiction than non-carriers as assessed by the Fagerstrom Test for Nicotine Dependence (P=1.2 × 10−4). The variant also confers risk of several serious smoking-related diseases previously shown to be associated with the D398N substitution in CHRNA5. We observed odds ratios (ORs) of 1.7–2.3 for lung cancer (LC; P=4.0 × 10−4), chronic obstructive pulmonary disease (COPD; P=9.3 × 10−4), peripheral artery disease (PAD; P=0.090) and abdominal aortic aneurysms (AAAs; P=0.12), and the variant associates strongly with the early-onset forms of LC (OR=4.49, P=2.2 × 10−4), COPD (OR=3.22, P=2.9 × 10−4), PAD (OR=3.47, P=9.2 × 10−3) and AAA (OR=6.44, P=6.3 × 10−3). Joint analysis of the four smoking-related diseases reveals significant association (P=6.8 × 10−5), particularly for early-onset cases (P=2.1 × 10−7). Our results are in agreement with functional studies showing that the human α4β2 isoform of the channel containing R336C has less sensitivity for its agonists than the wild-type form following nicotine incubation.
- Published
- 2016
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33. Synthesis and preliminary antimicrobial evaluation of some new 6-methoxyquinoline-3-carbonitrile derivatives
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Hagrs, Mohamed, Bayoumi, Ashraf H., El-Gamal, Kamal M., Mayhoub, Abdelrahman S., and Abulkhair, Hamada S.
- Abstract
A series of new 6-methoxyquinoline-3-carbonitrile derivatives were synthesized using a variety of synthetic routes. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. All of the synthesized compounds were evaluated for their in-vitro antimicrobial activity against Streptococcus pneumoniaand Bacillus subtilisas examples for Gram-positive bacteria, Pseudomonas aeruginosaand Escherichia colias examples for Gram-negative bacteria, and Aspergillus fumigatus, Syncephalastrum racemosum, Geotriucum candidumand Candida albicansas representative examples of fungi. The majority of tested compounds showed moderate activities against wide range of selected organisms. Among the tested compounds, the ester derivative 7band the thioether derivative 9cshowed the highest antimicrobial activity against gram-positive strains while the highest activity against gram-negative strains was observed in case of 7b, 7dand 9bwhile compound 7efound more active than Amphotericin B against three fungal species.
- Published
- 2015
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34. Oral rehydration solution containing trisodium citrate for treating severe diarrhoea: controlled clinical trial
- Author
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Mazumder, Ramendra N., Nath, S.K., Ashraf, H., Patra, F.C., and Alam, A.N.
- Subjects
Oral rehydration therapy -- Evaluation ,Diarrhea -- Complications ,Diarrhea -- Care and treatment - Published
- 1991
35. Does Contralateral Suppression at Adrenal Venous Sampling Predict Outcome Following Unilateral Adrenalectomy for Primary Aldosteronism? A Retrospective Study
- Author
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Wolley, Martin J., Gordon, Richard D., Ahmed, Ashraf H., and Stowasser, Michael
- Published
- 2015
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36. Role of pelvic floor muscle exercises in management of erectile dysfunction in patients with chronic obstructive pulmonary disease
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Mohammed, Ashraf H., Zedan, Moustafa A., and Ban, Hesham M.
- Abstract
The prevalence of sexual dysfunction in patients with chronic obstructive pulmonary disease is increased; skeletal muscle impairment is common and important complications of chronic obstructive pulmonary disease and pelvic floor muscle have an important role in sexual activity.
- Published
- 2015
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37. Evaluation of platelet-rich fibrin versus platelet-rich plasma on the outcome of mandibular fracture
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Al-Khawlani, Ebrahim, Adly, Osama A., Ahmed, Amal S., El-Desouky, Gihan G. El-din, Abass, Ashraf H., and Abdelmabood, Abdelbadia A.
- Abstract
The aim of the study was to evaluate the application of platelet-rich fibrin (PRF) versus platelet-rich plasma (PRP) on the outcome of mandibular fracture: a comparative study. This prospective comparative study was carried on 16 patients ranging in age from 20 to 42 years. The patients were divided into two equal groups. The results of this study showed that PRP and PRF seem to aid acceleration of bone healing in mandibular fractures, but PRF more so than PRP in bone formation.
- Published
- 2014
- Full Text
- View/download PDF
38. Strain imaging for evaluating response to thrombolytic therapy in pulmonary thromboembolism
- Author
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Jenab, Y., Jam, M. Saheb, Safir-Mardanloo, A., Ashraf, H., Ejmalian, G., Bozorgi, A., Sadeghian, H., Zoroufian, A., and Ghaffari-Marandi, N.
- Published
- 2014
- Full Text
- View/download PDF
39. Determination of antihepatitis B antibodies titer among a sample of compulsory fully vaccinated children and adolescents in Cairo, Egypt
- Author
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El-Melligy, Dalal M. and Shaalan, Ashraf H.
- Abstract
This study aims to determine the persistence of protective hepatitis B surface antibody (HBsAb) titer till adolescence following a full neonatal compulsory vaccination, whether booster doses are needed or not, and the best age for boosting if needed.
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- 2013
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- View/download PDF
40. Repeating adrenal vein sampling when neither aldosteronecortisol ratio exceeds peripheral yields a high incidence of aldosterone-producing adenoma
- Author
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Wolley, Martin, Gordon, Richard D., Pimenta, Eduardo, Daunt, Nicholas, Slater, Gregory J., Ahmed, Ashraf H., and Stowasser, Michael
- Abstract
In primary aldosteronism, adrenal vein sampling (AVS) suggests unilateral aldosterone-producing adenoma (APA) when the aldosteronecortisol (AF) ratio is less than or equal to peripheral on one side and at least two times peripheral on the other. When AF ratios are lower bilaterally than peripheral despite adequate samples (adrenal venous cortisol ≥3 times peripheral), we recommend repeat AVS. This study aimed to determine the frequency of this occurrence and outcomes in such cases.
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- 2013
- Full Text
- View/download PDF
41. Tonsillar Kaposi Sarcoma in a Patient with Membranous Glomerulonephritis on Immunosuppressive Therapy
- Author
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Al-Brahim, Nabeel, Zaki, Ashraf H., El-Merhi, Khaled, and Ahmad, Mahmoud S.
- Abstract
Kaposi sarcoma is a malignant vascular neoplasm uncommonly seen in immunosuppressed patients. Herein we report an unusual case of tonsillar Kaposi sarcoma in a patient with membranous glomerulonephritis treated with prednisolone and cyclosporine. The patient presented after 10 months of starting the treatment with a tonsillar mass. Histological examination was typical of monomorphic spindle cell proliferation with slit-like vascular channels. The tumor cells expressed CD34, D2–40 and positive nuclear stain for HHV-8. Kaposi sarcoma is associated with immunosuppression and rarely occurs in the tonsil. Clinicians should be aware of this rare presentation of Kaposi sarcoma.
- Published
- 2013
- Full Text
- View/download PDF
42. Repeated intracorporeal injection therapy for venogenic erectile dysfunction could salvage some penile prosthesis candidates
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Fayez, Ashraf H., Elkhiat, Yasser I., Awad, Hossam H., and Zaki, Shady H.
- Abstract
The aim of this work is to evaluate the therapeutic effect of repeated intracavernosal self-injection of vasoactive drugs for 1 month in patients with failed response to oral seldenafil and elevated end diastolic velocity (EDV) more than 5 cms as diagnosed by pharmacopenile duplex ultrasonography.
- Published
- 2012
- Full Text
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43. Effects of different combinations of benzyl adenine and indole acetic acid concentrations on in vitro plant regeneration in hexaploid wheat
- Author
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Fahmy, Ashraf H., Li, Jiarui, Abou El-Wafa, Walaa, El-Khodary, Soheir El-Saeed, and El Shihy, Osama M.
- Abstract
Development of a reliable in vitro plant regeneration procedure for hexaploid bread wheat (Triticum aestivumL.) is a prerequisite for its improvement by genetic transformation. Here, we report the effects of two growth regulators, benzyl adenine (BA) and indole acetic acid (IAA) on callus induction and plant regeneration from scutellum cultures of two commercial bread wheat cultivars: Giza 164 and Sakha 69. Callus induction was obtained from isolated embryos cultured on modified Murashige and Skoog (MS) basal medium. After four weeks of callus induction, all calli were plated on MS basal medium for regeneration. Wheat genotype and callus induction medium played a dominant role in plantlet regeneration. 2.0 mg/L BA and 0.2 mg/L IAA were the best combinations for inducing callus and let to highest regeneration frequency (81.67%) across the cultivars. Overall, based on our medium conditions, Giza 164 displayed higher regeneration frequency (81.11%) than Sakha 69. These results will facilitate genetic transformation for the economic varieties Giza 164 and Sakha 69.
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- 2012
- Full Text
- View/download PDF
44. The Performance of 5 Rapid HIV Tests Using Whole Blood in Infants and Children
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Sherman, Gayle G., Lilian, Rivka R., and Coovadia, Ashraf H.
- Abstract
Rapid tests have the potential to improve the identification of HIV-infected children in resource-limited settings. However, they remain underutilized because of a lack of data on their performance in the field using whole blood specimens. This study aimed to assess the accuracy of rapid tests for detecting HIV exposure, excluding HIV infection in HIV-exposed infants, and diagnosing HIV infection in children older than 18 months of age.
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- 2012
- Full Text
- View/download PDF
45. Nephron-sparing surgery for renal tumors
- Author
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Ezzat, Abd El Hamid H., Helmy, Ahmed, and Ibrahim, Ashraf H.
- Abstract
To report National Cancer Institute (NCI) experience in managing various benign and malignant renal tumors with nephron sparing surgery (NSS), and to assess its safety and feasibility.
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- 2011
- Full Text
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46. ORAL FLUID TESTS FOR SCREENING OF HUMAN IMMUNODEFICIENCY VIRUS-EXPOSED INFANTS
- Author
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Sherman, Gayle G., Lilian, Rivka R., and Coovadia, Ashraf H.
- Abstract
In high human immunodeficiency virus (HIV) prevalence settings, routine screening of infants attending immunization visits could improve identification of HIV-exposed infants to receive an early diagnosis and appropriate interventions. This first assessment of 2 rapid oral fluid HIV tests in early infancy demonstrates a sensitivity of <90% for detection of HIV-exposure resulting in failure to detect at least 1 in 10 HIV-infected infants.
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- 2010
- Full Text
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47. Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents
- Author
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Ashraf H, Abadi, Dalal A, Abouel-Ella, Nermin S, Ahmed, Bernard D, Gary, Jose T, Thaiparambil, Heather N, Tinsley, Adam B, Keeton, and Gary A, Piazza
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- 2009
- Full Text
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48. Dicyanomethylene compounds and heterocyclization of acylthiosemicarbazides
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Hassan, Alaa A., Mourad, Aboul‐Fetouh E., and Abou‐Zeid, Ashraf H.
- Abstract
(1,3‐Dioxo‐2,3‐dihydro‐1H‐inden‐2‐ylidene)propanedinitrile (1, in ethyl acetate solution), 3‐(dicyano‐methylene)‐2‐indolone (2, in ethanol/piperidine solution) and 7,7′,8,8′‐tetracyanoquinodimethane (3, in pyridine solution) act on substituted acylthiosemicarbazides 4a‐d, forming the derivatives of oxoindeno‐pyrrolylidenehydrazide (5a‐dand 7a‐d), thiazoloindolylidenehydrazide (12a‐d), pyrroloindolylidene‐hydrazide (13a‐d) and spiro[pyrrolylidene‐4,1′(cyclohexa‐2′,5′‐dienylidene)]propanedinitrile (18a‐d). Rationales for these conversiones involving the nucleophilic addition on dicyanomethylene carbon atom are presented.
- Published
- 2008
- Full Text
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49. Evaluation of the Ultrasensitive Human Immunodeficiency Virus Type 1 (HIV-1) p24 Antigen Assay Performed on Dried Blood Spots for Diagnosis of HIV-1 Infection in Infants
- Author
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Patton, Janet C., Coovadia, Ashraf H., Meyers, Tammy M., and Sherman, Gayle G.
- Abstract
ABSTRACTThe diagnostic accuracy of the modified p24 antigen assay performed on pediatric dried blood spots was evaluated. Samples analyzed within 6 weeks of collection yielded no false-positive results (specificity, 100%) and few false-negative results (sensitivity, 96.5% to 98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis.
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- 2008
- Full Text
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50. Uterine Myometrium as a Cell Patch as an Alternative Graft for Transplantation to Infarcted Cardiac Myocardium: A Preliminary Study
- Author
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Taheri, S.A., Yeh, J., Batt, R.E., Fang, Y., Ashraf, H., Heffner, R., Nemes, B., and Naughton, J.
- Abstract
Purpose Currently, only a small fraction of patients are able to receive reperfusion therapy for myocardial infarctions. We hypothesize that myometrial cell patch transplantation could be an alternative approach for the treatment of myocardial infarction.Design We performed a preliminary study to determine the feasibility of this novel therapeutic approach in a rabbit model.Procedures Six adult female New Zealand rabbits were used. Myocardial infarction was induced by left anterior descending artery ligation. A segment of uterus was removed via a laparotomy incision, and this uterine segment was transplanted as an autologous graft over the infarcted myocardium, which was then reinforced by greater omentum.Statistical methods and outcome measures Hemodynamic measurements and histological studies. Main findings: All uterine myometrial patches survived in the test animals. Fluoroscopic hemodynamic measurements were made for ejection fractions at 8 weeks after the application of the uterine patch. Histological study demonstrated well-healed myometrial-myocardium junctions with minimum scar tissue. Angiogenesis occurred in the transplanted myometrium. Connexin 43 expression was demonstrated in the transplanted patches.Conclusion Our noncontrolled preliminary rabbit experiments indicate that patches of uterine myometrium reinforced by greater omentum can be used as autologous transplant therapy for infracted myocardium. This is an innovative technique that could lead to future treatment for individuals who may suffer from an infarcted myocardium and may not be eligible for traditional reperfusion therapy.
- Published
- 2008
- Full Text
- View/download PDF
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