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Propagation-based phase-contrast x-ray imaging (PB-PCXI) generates image contrast by utilizing sample-imposed phase-shifts. This has proven useful when imaging weakly attenuating samples, as conventional attenuation-based imaging does not always provide adequate contrast. We present a PB-PCXI algorithm capable of extracting the x-ray attenuation  β and refraction  δ, components of the complex refractive index of distinct materials within an unknown sample. The method involves curve fitting an error-function-based model to a phase-retrieved interface in a PB-PCXI tomographic reconstruction, which is obtained when Paganin-type phase retrieval is applied with incorrect values of δ and β. The fit parameters can then be used to calculate true δ and β values for composite materials. This approach requires no a priori sample information, making it broadly applicable. Our PB-PCXI reconstruction is single-distance, requiring only one exposure per tomographic angle, which is important for radiosensitive samples. We apply this approach to a breast-tissue sample, recovering the refraction component  δ, with 0.6–2.4% accuracy compared with theoretical values.

We present the implementation of a computed tomography (CT) iterative reconstruction strategy developed within the SYRMA-CT project for in vivo phase-contrast CT of uncompressed breast, ongoing at the ELETTRA synchrotron radiation facility (Trieste, Italy). Propagation-based phase-contrast imaging exploits the high spatial coherence of the monoenergetic laminar X-ray beam, as well as the large object-to-detector distance and the use of a Pixirad-8 high-resolution photon-counting CdTe detector. The signal in projection views depends on the X-ray absorption as well as on the phase shift introduced by the breast tissue in the beam path. A phase retrieval algorithm allowed recovering the projected 2-D phase information of the irradiated tissue layer, which was input to the CT reconstruction; then, the breast slices were reconstructed via a simultaneous algebraic reconstruction technique algorithm. Our iterative reconstruction-coupled with a filtering process for reducing the noise level and ring artifacts while preserving edges sharpness-showed better image quality than conventional filtered back projection (FBP) reconstruction. This phantom study showed that our iterative reconstruction produced images with higher contrast-to-noise ratio and spatial resolution than those obtained with FBP. Finally, the developed algorithm removed ring-like artifacts, without worsening the image quality.

An analyzer-based X-ray phase contrast imaging setup (ABI) based on four bounce Si(444) monochromators at 18 keV mounted at the SYRMEP beamline at Elettra is presented. The system was stable for the employed exposure times. Contrasts, visibility of the object edges and signal to noise ratio of the acquired images were studied. Simulation procedures of the images were also exploited. The results show that such setup can be used for high sensitivity (high contrast) experiments at Elettra. Also, due to intrinsic properties, this setup can be useful for future ultra-small angle X-ray scattering experiments. (© 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Diffraction enhanced imaging (DEI) uses refraction of x-rays at edges, which allows pronounced visualization of material borders and rejects scattering which often obscures edges and blurs images. Here, the first evidence is presented that, using DEI, a destruction-free evaluation of the quality of integration of metal implants into bone is possible. Experiments were performed in rabbits and sheep with model implants to investigate the option for DEI as a tool in implant research. The results obtained from DEI were compared to conventional histology obtained from the specimens. DE images allow the identification of the quality of ingrowth of bone into the hydroxyapatite layer of the implant. Incomplete integration of the implant with a remaining gap of less than 0.3 mm caused the presence of a highly refractive edge at the implant/bone border. In contrast, implants with bone fully grown onto the surface did not display a refractive signal. Therefore, the refractive signal could be utilized to diagnose implant healing and/or loosening.

The SYRMEP (SYnchrotron Radiation for MEdical Physics) collaboration is presently taking data at a beamline at the synchrotron ELETTRA in Trieste to study the performances of a digital silicon pixel imaging system for mammography. Images are obtained with a scanning technique in the energy range 15–30keV. The readout electronics operates in a single photon counting mode with a photon rate of about 106/(mm2s), which is still 4 times lower than the maximum rate reachable with the present beamline configuration. Two different detector layouts have been designed, the first one consisting of a single-layer silicon microstrip detector positioned edge-on with respect to the beam, and the second innovative one represented by a matrix of these detectors stacked to cover the full beam dimension (100×4mm2). We present here the results obtained with a single-layer detector and a double-layer detector (both 5cm wide) with mammographic phantoms and human breast tissue.

The knowledge of the dose and of the energy spectrum of the X-rays delivered to the patient during a radiological examination allows in principle the computation of the number of photons per unit surface useful for a good mammography. The film-screen assembly detectors used in the present standard practice require a number of photons per unit surface which, from a statistical point of view, would be unnecessarily high if single photon counting detectors with efficiency near to one were available. We discuss a possible solid state detector with these characteristics. Moreover, we propose the use of an X-ray monochromatic beam from a synchrotron radiation source in order to perform the examination at the energy where the signal to noise ratio has a maximum. Using the proposed detector in such a beam a substantial dose reduction can be foreseen.

The SYRMEP collaboration is developing a digital mammography project using a synchrotron radiation monochromatic X-ray beam and a silicon pixel detector. The combination of a monochromatic laminar beam with a high efficiency laminar detector, capable of single-photon counting, allows one to minimize the radiation dose delivered to the sample, while maximizing contrast resolution and dynamic range. The SYRMEP detector is a silicon microstrip device used in an innovative configuration in which radiation impinges on the side rather than on the surface of the chip and is therefore totally absorbed within the detector active volume. The high contrast resolution and spatial resolution (<100 microns) of the system have been demonstrated by producing images of details from an Ackermann Mammographic Phantom RMI 160 illuminated by a conventional X-ray tube.

The SYRMEP approach to digital mammography implies the use of a monochromatic X-ray beam from a synchrotron source and a slot of superimposed silicon microstrip detectors as a scanning image receptor. The microstrips are read by 32-channel chips mounted on 7-layer hybrid circuits which receive control signals and operating voltages from a MASTER-SLAVE configuration of cards.