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1. Human circulating plasma DNA significantly decreases while lymphocyte DNA damage increases under chronic occupational exposure to low-dose gamma-neutron and tritium β-radiation

Author

Korzeneva, Inna B., Kostuyk, Svetlana V., Ershova, Liza S., Osipov, Andrian N., Zhuravleva, Veronika F., Pankratova, Galina V., Porokhovnik, Lev N., and Veiko, Natalia N.

Abstract

•The chronic exposure to low-dose IR induces DSBs in human lymphocytes (TM index).•Exposure to IR decreases the level of human circulating DNA (cfDNA index).•IR induces an increase of DNase1 activity (DNase1 index) in plasma.•IR induces an increase of the level of antibodies to DNA (Ab DNA index) in plasma.•The ratio cfDNA/(DNase 1×Ab DNA×TM) is a potential marker of human exposure to IR.

Published
2015
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