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AbstractGenerally, herbal medicines having remarkable popularity for treating liver ailments, but they are still unacceptable because of the deprivation of herbal drug standardization. Therefore, there is a need for promising synthetic drugs to overcome the critical liver problem. We introduce 1, 3, 4-oxadiazine ring in this study to identify better anti-hepatotoxic agents via a suitable synthetic route. These oxadiazine-based derivatives were structurally confirmed by analytical and spectral data and evaluated for their anti-hepatotoxic potential. Further, in vitrohepatotoxicity studies have been done to check the toxicity level in the synthesized compound. Compounds 5a, 5b, 5cand 9dwere selected for further biological evaluation according to in vitroresults. After that, CCl4-induced animal model was used to evaluate in vivoanti-hepatotoxicity activity. Compound 5awith 52.99%, 59.3%, 79.34% and 5bwith 52.16%, 57.65%, 75.10% revealed to be most promising for reduction in level of SGPT, SGOT and ALKP, respectively. Moreover, it was also observed that the compound 5awith 411.01%, 53.39% and 5bwith 378.63%, 48.9% level of albumin and total protein were respectively. The induced-fit docking results of the compounds 5aand 5breveal some essential binding information and exhibited desirable ADME properties, and obeyed Lipinski's rule of five. In addition, molecular dynamics studies for 100 ns further confirm the protein-ligand complex's stability, supporting the in vitroand in vivodata, and help in establishing the SAR of synthesized compounds. Two compounds, 5aand 5 b, exhibited higher anti-hepatotoxic activity than the standard drug silymarin.

The aerial part of Thymus cilicicus Linn. (Labiatae) has afforded two new hydroxy chalcone derivatives, characterized as 4, 2′, 4′, 6′, 7, 8-hexahydroxy-7 (8)-dihydro-chalcone (1), and 3, 4, 2′, 4′, 6′, 7, 8-heptahydroxy-7 (8)-dihydro-chalcone (2). The structures of the isolated compounds have been elucidated based on various spectral studies.

The aerial parts of Crotalaria emarginella Vatke (Leguminosae) have afforded a new steroidiridoid, characterized as 1’-hydroxy-isoiridomyrmecinyl- 1’-O-β -3-O-α-stigmast-5-ene, designated as crotasteroiridocin (1), which shows a unique combination of iridoid and sterol units, found very rarely in nature. Furthermore, a rare iridoid glucoside namely, bis-desoxy-dihydro-monotropein (2) has also been isolated from the aerial parts of the plant. The structures of the isolated products were elucidated on the basis of spectral and chemical studies. The anti-inflammatory activity has also been screened, wherein compounds 1 and 2 have shown 25.92% and 28.39% activity respectively, with respect to phenyl butazone against carrageenan employing the rat paw method.

Two new diterpenes namely verbenacine (1) and salvinine (2) have been isolated from the aerial parts of Salvia verbenaca. Their structures have been elucidated on the basis of chemical and spectral data as 3a-hydroxy-19-carboxykaur-15-ene and 19-hydroxy-12,14-dioxo labda-15,17-diene.

The aerial parts of Barbeya oleoides Schweinf (Family: Barbeyaceae) has afforded a new phenolic indane type component, which has been characterized as (6R, 4aR, 5aR)-5, 4a, 5atrihydroindeno- (1, 2-a) indane-2, 4, 9-triol-6-O-ß-acetate (1) on the basis of spectral analysis and has been designated as barbeyol.

The aerial parts of Hypoestes verticillaris (L.F.) Sol. (Acanthaceae) has afforded a new seco -fusicoccane diterpenoid ketonepoxide, which was characterized as 1(10) seco -fusicocc-3 (4)-ene-5, 11, 14-trione-8 (9), 1 (7)-diepoxide ( 1 ) on the basis of spectral analysis and named as verticillarone, along with earlier reported diterpenoid, i.e. 13-hydroxy-7-oxo-labda-8, 14-diene ( 2 ).

The modulating effect of Lupeol [lup-20(29)-en-3 β-ol], a triterpene found in many fruits and medicinal plants, on benzoyl peroxide-induced tumor promotion responses or tumor promotion in murine skin is described. Benzoyl peroxide is an effective cutaneous tumor promoter acting through the generation of oxidative stress, the induction of ornithine decarboxylase activity and the enhancement of DNA synthesis. Benzoyl peroxide treatment increases cutaneous microsomal lipid peroxidation and hydrogen peroxide generation. The activity of the cutaneous antioxidant enzymes, namely catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase, is decreased and levels of cutaneous glutathione are depleted. Benzoyl peroxide treatment also induces ornithine decarboxylase activity and enhances [3H]thymidine uptake in DNA synthesis. Prophylactic treatment of mice with lupeol (0.75 and 1.5 mg per animal) 1 hour before benzoyl peroxide treatment resulted in a diminution of benzoyl peroxide-mediated damage. The susceptibility of cutaneous microsomal membrane to lipid peroxidation and hydrogen peroxide generation was significantly reduced (P< 0.01 and P< 0.01, respectively). In addition, depleted levels of glutathione and inhibited activity of antioxidant enzymes were recovered to a significant level (P< 0.01, P< 0.05 and P< 0.01, respectively). Similarly, the elevated ornithine decarboxylase activity and enhanced thymidine uptake in DNA synthesis were inhibited significantly (P< 0.05) in a dose-dependent manner. The protective effect of lupeol was dose dependent in all parameters. The results suggest that lupeol is an effective skin chemopreventive agent that may suppress benzoyl peroxide-induced cutaneous toxicity.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

2[2-Oxo-phenyl hydrazinyl ether] benzamide (2BA) was synthesized, characterized and tested effective for corrosion inhibition of mild steel in 1 N H2SO4 solution using galvanodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. Polarization resistances calculated from the EIS measurements are in good agreement with those obtained from alternating current (AC) polarization measurements. The mild steel samples were also analyzed by Scanning Electron Microscopy (SEM). The result showed that 2BA is an excellent inhibitor for mild steel in acid medium. The inhibition was assumed to occur via adsorption of the inhibitor molecule on the metal surface. In the 303-323K temperature range, the 2BA adsorption follows Langmuir isotherm model. The protection efficiency increases with increasing the inhibitor concentration in the range of 250-1000 ppm but slightly decreases with increasing temperature.

We have isolated three pyridine base alkaloids namely ricinine (C1), N-demethylricinine (C2) and 4-methoxy pyridine-3-carboxylic acid (C3) from methanolic extract of Riccinus Communis leaves and investigated corrosion inhibition effect on mild steel in 0.5 HCl solution using the weight loss and electrochemical techniques (Galvanostatic polarization and EIS). Polarization resistances calculated from the EIS measurements are in good agreement with those obtained from alternating current (AC) polarization measurements. The mild steel samples were also analyzed by Scanning Electron Microscopy (SEM). The results show that C1 is an excellent inhibitor for mild steel in acid medium. The inhibition was assumed to occur via adsorption of the inhibitor molecule on the metal surface. In the 298- 308 K temperature range, the C1, C2 and C3 adsorption follows Langmuir isotherm model. The protection efficiency increases with increasing the inhibitor concentration in the range of 250-1000 ppm but slightly decreases with increasing temperature.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

For Abstract see ChemInform Abstract in Full Text.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.