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Without a cure for dementia, the focus is currently aimed at reducing modifiable lifestyle risk factors for dementia, including depression, social isolation, diabetes, smoking, midlife obesity, hypertension, physical inactivity, and alcohol overconsumption among others. Several multidomain dementia risk reduction interventions have shown promise in reducing cognitive decline and dementia risk in at-risk individuals. This review summarizes the evidence and discusses the barriers and facilitators to screening for and treating personalized risk factors in clinical settings. Psychology and psychiatry can improve current dementia risk reduction approaches through the application of motivation and behavior change principles.