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Addison's disease, also known as hypoadrenocorticism, is a difficult disease to identify in dogs due to its vague and inconsistent symptoms. The disease is caused by underactive adrenal glands that produce too little natural steroid, which can be life-threatening. Diagnosis can be challenging as the symptoms resemble those of other diseases, and special testing is required for confirmation. Treatment involves glucocorticoid and mineralocorticoid therapy, and the prognosis with treatment is generally excellent. Addison's disease is considered rare overall in dogs, but certain breeds are at an increased risk. [Extracted from the article]

A clinical trial, NCT06644924, is being conducted by AstraZeneca to evaluate the therapeutic efficacy and safety of inhaled PT007 (AS MDI) compared to placebo MDI and Ventolin Evohaler in adult participants with asthma. The study involves a screening/run-in period, treatment period, and follow-up phone call, with primary outcome measures focusing on changes in lung function. Recruitment for the study is not yet active, with enrollment expected to be 102 participants, and the primary completion date set for September 22, 2025. The study aims to assess the bronchodilatory effect and safety of the interventions in a randomized, double-blind, crossover design. [Extracted from the article]

A 25-year-old woman with lupus myopericarditis developed myocardial dysfunction while being treated with hydroxychloroquine. Despite also receiving colchicine, she showed lack of efficacy in her treatment. The woman underwent pericardiocentesis and was managed with various medications, including hydrocortisone, empagliflozin, lisinopril, spironolactone, beta blockers, and diuretics. Her hospital stay was prolonged due to volume overload, but she was eventually discharged. [Extracted from the article]

Researchers from Shri Ramdeobaba College of Engineering & Management in Nagpur, India have conducted a review on cortisol detection methods for stress monitoring. Cortisol, known as the "stress hormone," plays a crucial role in controlling various physiological functions. Accurate monitoring of cortisol levels is important for determining health, identifying stress-related disorders, and improving the management of stress-related conditions. The review provides an analysis of the available techniques for cortisol monitoring, discusses the challenges associated with them, and offers suggestions for ongoing observation. The research serves as a guide for improving cortisol detection and stress monitoring. [Extracted from the article]

A recent study published in Human Reproduction has found that women with premature ovarian insufficiency (POI) are at a higher risk of developing severe autoimmune diseases such as Type I diabetes, Addison's disease, lupus, and inflammatory bowel disease. The study, which followed nearly 20,000 women, is the largest of its kind and is the only one to compare women with POI to a control group of similar ages. The researchers suggest that autoimmune processes may play a significant role in the onset of POI. While most women with POI do not develop severe autoimmune conditions, medical professionals should be aware of the increased risk, and patients should be informed about it as well. [Extracted from the article]

A recent report from the University of Edinburgh provides an update on the rare condition of hypoadrenocorticism, or Addison's disease, in cats. The condition has only been documented in approximately 40 cases over the past 40 years since it was first described in 1983. Feline hypoadrenocorticism remains challenging to diagnose and treat due to its rarity and fluctuating clinical signs. The diagnosis is made through an adrenocorticotropic hormone (ACTH) stimulation test, and long-term treatment involves oral corticosteroids and mineralocorticoids. The condition is not associated with any specific breed, sex, or age, although cats under 6 years old are overrepresented. [Extracted from the article]

2023 JUN 3 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- A new study on cryptococcosis is now available. According to news originating [...]

Cushing's disease, also known as hyperadrenocorticism (HAC) or Cushing's syndrome, occurs in dogs when their bodies have an excess of steroids. This can be due to either natural steroid production or the administration of steroid medications. There are four different types of HAC that can cause the same symptoms, including pituitary-dependent HAC (PDH), adrenal tumor (AT), iatrogenic HAC, and atypical HAC. Treatment options include medications such as trilostane or mitotane, surgery, or radiation therapy. With appropriate treatment, the prognosis for dogs with Cushing's disease is generally good, with a median survival time of around two years. [Extracted from the article]

A recent study conducted by researchers at Dr. D.Y. Patil Vidyapeeth in Maharashtra, India, has shed light on the connection between Addison's disease and Posterior Reversible Encephalopathy Syndrome (PRES). Addison's disease, previously thought to be caused by infection, is now understood to have an autoimmune basis. The study reports a case of a patient with Arnold Chiari malformation who experienced a seizure and diarrhea, and was subsequently diagnosed with PRES and Addison's disease. The researchers emphasize the importance of prompt diagnosis and intensive treatment for PRES to improve prognosis. [Extracted from the article]

A 60-year-old woman developed autoimmune polyendocrine syndrome type 2 (APS-2) during treatment with camrelizumab and experienced drug intolerance during treatment with cisplatin for squamous carcinoma of the urethral meatus and lymph node metastases. She initially received camrelizumab and developed hypothyroidism, which was treated with levothyroxine-sodium. Later, she developed symptoms of fatigue, nausea, epigastric discomfort, and vomiting, and was diagnosed with diabetic ketoacidosis (DKA) and primary adrenal insufficiency (Addison's disease), indicating APS-2 secondary to camrelizumab. She received treatment and eventually recovered. She later started chemotherapy with cisplatin but had poor tolerance to it and switched to gemcitabine monotherapy. After radiotherapy and paclitaxel chemotherapy, her physical condition deteriorated, and she was lost to follow-up. [Extracted from the article]

A 73-year-old woman experienced right heart failure and hypokalaemia while being treated with hydrocortisone and fludrocortisone for primary adrenal insufficiency. She presented to the emergency department with symptoms of vomiting, diarrhea, and altered mental status. The woman had a history of autoimmune thyroiditis and hypokinetic cardiomyopathy, and had recently received corticosteroid therapy for vertiginous symptoms. After receiving treatment with sodium-chloride and IV hydrocortisone, her sodium levels normalized and she showed clinical improvement. However, she developed right heart failure and hypokalaemia as a result of the hydrocortisone and fludrocortisone. These conditions were resolved after adjusting her treatment regimen, and she was diagnosed with autoimmune Addison's disease. [Extracted from the article]

A recent study conducted in Cluj Napoca, Romania, explores the condition known as "Petrified Ear" (PE), which refers to the calcification or ossification of auricular cartilage. The researchers aimed to analyze the data on PE and its association with endocrine conditions. The study included 75 subjects with PE, with 23 classified as having endocrine PE (EPE). The most common endocrine conditions associated with EPE were adrenal insufficiency, hypopituitarism, and hypothyroidism. The researchers propose the term "endocrine petrified ear" and suggest a workflow algorithm to assess the potential hormonal/metabolic background in PE. [Extracted from the article]

David Morris examines the links between conditions such as hypothyroidism and type 1 diabetes [ABSTRACT FROM AUTHOR]

The article discusses that friend's close call prompted Alf Larcher to investigate the causes, effects and treatment of Addison's disease. It mentions that the this story begins with a close friend of mine, who had been unwell for some time; and he became very weak, and his family insisted on taking him to hospital.

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corti-costeroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorder PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

The article discusses a clinical trial called RESTORE, which aims to compare two strategies for reducing fractures and improving outcomes for fragility fractures. One strategy involves patient navigation and referral to a bone health provider, while the other involves patient and physician education. The trial also aims to determine how various factors influence the effectiveness of these strategies. The trial is not yet recruiting and is estimated to enroll 2634 participants. The article provides general information on the trial without specific details or findings. [Extracted from the article]

A recent report from Tamil Nadu, India, discusses a case of adrenal insufficiency caused by tuberculosis of the adrenal gland. The patient, a 43-year-old male with pulmonary tuberculosis and chronic coronary syndrome, experienced symptoms such as hyponatremia, hypotension, and shock during treatment with anti-tubercular therapy. After further investigation, adrenal insufficiency was suspected and confirmed through tests. The patient was subsequently treated with prednisolone and the full dose of anti-tubercular therapy, leading to the resolution of symptoms. This research highlights the importance of recognizing adrenal tuberculosis as a potential cause of adrenal insufficiency, particularly in developing countries like India. [Extracted from the article]

A recent review conducted by researchers at the University of Verona in Italy focuses on respiratory complications in autoimmune rheumatic diseases within intensive care units (ICUs). The review highlights the importance of early recognition and treatment of non-malignant conditions to prevent rapid disease progression and organ system failure. Mortality rates for rheumatic diseases in the ICU are higher than those of other conditions, emphasizing the need for specialized care and proactive management. The review emphasizes comprehensive assessments, accurate diagnosis, and vigilant monitoring to enhance patient outcomes. [Extracted from the article]

Researchers from Cukurova University in Adana, Turkey have published a new study on Addison's disease. The study focuses on a case of a 47-year-old woman who was diagnosed with both essential thrombocythemia and Addison's disease. The researchers highlight the challenges of managing these complex, coexisting conditions and emphasize the importance of an integrated approach. The patient experienced significant symptom alleviation and stabilization of her condition with tailored therapy targeting both endocrine and hematological aspects. The study underscores the need for comprehensive evaluation in patients with non-specific systemic symptoms to identify potential concurrent medical diagnoses. [Extracted from the article]

Researchers at the Pratima Institute of Medical Sciences have reported new findings on adrenal insufficiency, specifically primary adrenal insufficiency (PAI), also known as Addison's disease. The study describes a case report of a 32-year-old female who presented with symptoms such as weakness, fatigue, weight loss, and hyperpigmentation. Based on her symptoms and laboratory findings, a diagnosis of Addison's disease was made. The patient was started on hormone replacement therapy, which significantly improved her symptoms. For more information, the full case report can be accessed through Perspectives In Medical Research. [Extracted from the article]

A recent report from Robert-Debre University Hospital in Paris, France highlights the dangers of excessive pickle consumption, specifically in relation to adrenal crisis. The report discusses the case of a 13-year-old child who experienced severe hypovolemic shock and cardiac arrest after consuming large amounts of pickles over several months. The child was ultimately diagnosed with autoimmune Addison's disease, a rare and life-threatening condition. The researchers emphasize the importance of considering this diagnosis in cases of unexplained collapse, hypotension, vomiting, or diarrhea, particularly when accompanied by hyponatremia. [Extracted from the article]

This patent application discusses the potential uses of antibodies that target a protein called butyrophilin-2 (BTN2). These antibodies have the ability to inhibit the production of certain cytokines, inhibit the cytolytic function of specific T cells, and inhibit the proliferation of certain T cells. The application provides specific examples of these antibodies and their compositions. The antibodies have the potential to be used as immunosuppressive agents for the treatment of autoimmune diseases and to prevent transplant rejection. The application also mentions various autoimmune and inflammatory disorders that could potentially be treated with these antibodies, including rheumatoid arthritis, diabetes, multiple sclerosis, Crohn's disease, and lupus. [Extracted from the article]

A 90-year-old man with Addison's disease developed perforated diverticulitis while being treated with hydrocortisone and fludrocortisone. He also experienced lack of efficacy when treated with methylprednisolone. The man presented with symptoms such as hoarseness, shortness of breath, weakness, and abdominal discomfort. He underwent surgery to address the perforated diverticulitis and experienced complications such as an adrenal crisis and an abdominal abscess. The perforated diverticulitis was determined to be a result of the hydrocortisone and fludrocortisone treatment. [Extracted from the article]

A 51-year-old man experienced gastritis and xerostomia while being treated with methotrexate and ciclosporin. He also developed chronic adrenal insufficiency due to intentional misuse and non-compliance with methylprednisolone. The man was admitted to the hospital with symptoms of dry mouth, difficulty swallowing, weakness, blurred vision, itchy skin, and fever. He was diagnosed with severe psoriasis vulgaris, acute circulatory collapse, anaemia of inflammation, acute kidney injury, dehydration, gastritis, malnutrition, and urinary tract infections. Despite treatment, his condition worsened, and he eventually passed away. [Extracted from the article]

A 56-year-old woman with polyglandular autoimmune syndrome type 2, including primary adrenal insufficiency, type 1 diabetes, Addison's disease, and hypothyroidism, experienced a lack of efficacy with hydrocortisone treatment for adrenal crisis. Despite receiving optimal dosing, her ACTH levels remained elevated, indicating the treatment was not effective. Further tests, including a dexamethasone suppression test and imaging scans, did not reveal any underlying pathology. The woman was eventually switched to prednisone, which resulted in a decrease in ACTH levels, and hydrocortisone was discontinued. [Extracted from the article]

A recent study conducted by researchers at the University of Bergen in Norway explored the role of copy number variations (CNVs) in autoimmune Addison's disease (AAD). AAD is a rare endocrine disorder caused by the autoimmune destruction of the adrenal cortex. The study found that while rare CNVs did not appear to be a major cause of AAD, larger deletions (>1,000 kb) were more common among patients. However, none of these large deletions were conclusively pathogenic, and further research is needed to understand the potential contribution of rare deletions to AAD susceptibility. [Extracted from the article]

4A Corticosteroidresponsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-resnsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorders PRESCRIBING NOTES Corticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include: Adrenocortical insufficiency: Hydrocortisone, cortisone; prednisone [...]

4A Corticosteroid-responsive disorderPRESCRIBING NOTESCorticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include:Adrenocortical insufficiency:Hydrocortisone, cortisone; prednisone or prednisolone (with mineralocorticoid).Rheumatic [...]

This document provides information about a clinical trial, NCT06309498, that is currently recruiting participants in Italy. The trial focuses on adrenal insufficiency, specifically in patients with autoimmune Addison's disease. The study aims to measure 11-deoxycorticosterone (11 DOC) levels in order to assess residual adrenal function and its potential impact on adrenal crisis and complications. The trial hopes to improve the management and treatment of Addison's disease, potentially reducing the need for hormone replacement therapy and improving patients' quality of life. Contact information for the primary investigator is provided for those interested in participating. [Extracted from the article]

A systematic review conducted by researchers at Autonomous University in Madrid, Spain, explored the cognitive impairment in patients with Addison's disease (AD), a chronic condition characterized by insufficient production of certain hormones. The review included 10 articles and found that patients with AD exhibited moderately reduced performance in verbal learning. Episodic memory was the most commonly impaired cognitive domain. The study suggests that future research should include larger sample sizes, comprehensive neuropsychological assessments, and neuroimaging. [Extracted from the article]

Rod and Monica, a married couple in Sydney, have been living in their seaside home for over 50 years. However, as they have aged, the house has become increasingly difficult for them to navigate. Additionally, Monica's illness, Addison's disease, has added to their challenges. Fortunately, they have received assistance from The Benevolent Society's Aged Care Services, which provides a home care package that includes household chores and transportation for Monica. Despite their difficulties, Rod and Monica are determined to stay in their beloved home. [Extracted from the article]

A recent study from the University of Aleppo in Syria provides new insights into Allgrove Syndrome, a rare autosomal recessive disease caused by mutations in the AAAS gene. The study presents a case of a 16-year-old boy with Triple-A Syndrome, a variant of Allgrove Syndrome, who exhibited neuromuscular manifestations along with symptoms such as painful swallowing, fatigue, and congenital ptosis. The report emphasizes the importance of recognizing atypical presentations of Triple-A Syndrome for early diagnosis and appropriate management. Treatment options for Allgrove Syndrome include artificial tears, glucocorticoid replacement therapy, and treatment of achalasia. [Extracted from the article]

A recent report from Ivano-Frankivsk National Medical University discusses the prevalence and etiologic factors of primary adrenal insufficiency, a condition caused by insufficient secretion of adrenal hormones. The study highlights the importance of timely diagnosis and treatment, as late detection can lead to complications. The report also presents a clinical case of a patient with both primary adrenal insufficiency and Werlhof's disease, emphasizing the need for awareness and vigilance among doctors regarding the symptoms of adrenal insufficiency. The research concludes that early intervention improves disease prognosis and quality of life. [Extracted from the article]

A recent report from the All India Institute of Medical Sciences (AIIMS) discusses a case of a 20-year-old female with Type 1 Diabetes Mellitus (T1DM) who also presented with other autoimmune disorders, including Chronic Kidney Disease (CKD), hypothyroidism, and hypertension. The patient was diagnosed with Autoimmune Polyglandular Syndrome type 3 (APS3), which is characterized by autoimmune thyroiditis and other organ-specific autoimmune diseases. Interestingly, the patient exhibited a rare presentation of hypercortisolism instead of Addison's disease. The management of her diabetes was challenging due to the brittle diabetes pattern she showed, and the diagnosis of hypercortisolism was complicated by the co-existing CKD. This research provides insights into the complexities of autoimmune disorders and highlights the need for an internist approach in such cases. [Extracted from the article]

4A Corticosteroid-responsive disordersPRESCRIBING NOTESCorticosteroids are potent drugs that affect many organ systems. The doses of these drugs must be individualized. Corticosteroid-responsive conditions include:Adrenocortical insufficiency:Hydrocortisone, cortisone; prednisone or prednisolone (with mineralocorticoid).Rheumatic [...]

A study conducted by researchers at Wroclaw Medical University in Poland examined the health-related quality of life (HRQoL) in patients with primary adrenal insufficiency (PAI). The study included 32 patients with autoimmune PAI who completed the quality of life in Addison's disease questionnaire (AddiQoL). The results showed that males had higher AddiQoL scores compared to females, and there was a negative correlation between HRQoL and gonadotropin levels. The study also found that the presence of autoimmune comorbidities did not significantly affect AddiQoL scores, but fatigue scores were worse in the presence of autoimmune thyroiditis. Overall, the study concluded that female sex, higher gonadotropin levels, and older age at diagnosis were associated with impaired HRQoL in patients with PAI. [Extracted from the article]

A recent study conducted at the University of Tunis El Manar in Tunisia examined the adherence to glucocorticoid replacement therapy in patients with Addison's disease (AD) and its association with patients' disease knowledge and quality of life. The study included 58 patients with AD, and it was found that 46% of them were non-adherent to glucocorticoid replacement therapy. Factors such as age, poor adherence to comorbidity treatments, history of adrenal crisis, and poor knowledge about the disease were associated with non-adherence. The study concluded that therapeutic education is crucial in reducing non-adherence, especially among young patients. [Extracted from the article]

Eric Cole, a professional golfer, shares his journey of overcoming obstacles to reach the PGA Tour. Growing up with parents who were pro golfers, Cole developed a passion for the game and received guidance from both his mother and father. However, during college, he was diagnosed with type 1 diabetes and Addison's disease, which affected his health and golf career. Despite setbacks, Cole persevered, playing on mini-tours and eventually earning his PGA Tour card in 2022. Although he faced challenges during his rookie season, Cole remains determined and hopeful for success in his professional golf career. [Extracted from the article]

A report from researchers at the University of Bergen in Norway discusses the topic of adrenal insufficiency, a condition where the adrenal glands do not produce enough hormones. The report focuses on autoimmune primary adrenal insufficiency, which is the most common cause of the condition. It provides an overview of the physiology of the adrenal glands, the different causes of adrenal insufficiency, and the genetic factors involved. The report also discusses the autoimmune mechanisms underlying the condition and the importance of autoantibodies in diagnosis. The researchers emphasize the need for early identification and targeted treatment of autoimmune primary adrenal insufficiency. [Extracted from the article]