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Start Over Author "Adamiak, Beata" Publication Type Magazines
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1. The Synthesis and Biological Evaluation of Two Analogues of the C-Riboside Showdomycin

Author

Renner, Jens, Kruszelnicki, Irma, Adamiak, Beata, Willis, Anthony C., Hammond, Edward, Su, Stephen, Burns, Christopher, Trybala, Edward, Ferro, Vito, and Banwell, Martin G.

Abstract

Two novel analogues, 2 and 3, of the C-riboside showdomycin (1) have been prepared by exploiting the N-TIPS-substituted pyrrole 7 as a synthetic equivalent for the maleimide C3 anion. The tetraacetate precursor, 12, of target 2 as well as target 3 itself were subjected to single-crystal X-ray analyses. Analogues 2 and 3 as well as showdomycin and its anomer (4) have each been evaluated in various assays for their cytotoxic, anti-bacterial, and anti-viral effects.

Published
2005
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