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Prostaglandins modulate cytokine release though increases in cAMP, regulating interleukin (IL) 6 and IL-10. Diclofenac inhibits cyclo-oxygenase activity and hence prostaglandin production. We hypothesized that diclofenac would affect release of IL-6 and IL-10 and modulate the immune response.

Abstract: The Umm Nar BIF was formed in a sedimentary environment. It is confined to an upper stratigraphic zone of pre-Pan-African metamorphosed shelf deposits. During the Pan-African deformational history, the BIF and the host metasediments were tectonically' overlain by ophiolitic melange succession. The metasediments and the mlange were subjected to a major folding phase and then thrust over the “Shaitian” sheared granite, prior to the intrusion of syn- to late- orogenic granitoids. The BIF is divisible into two main types: oxide-bands including magnetite and hematite, and oxide-silicate bands including magnetite, hematite and stilpnomelane. The associated gangues are quartz, calcite, epidote, garnet, plagioclase, graphite and muscovite. Rhythmic banding and lamination, cross-lamination and flaser structure are the most prominent primary features in the IF bands. The iron minerals and the associated gangue show a variety of textural aspects and microscopic interrelationships which indicate successive episodes of mineral accumulation and formation, involving deposition, recrystallization, blastic growths, overgrowths, replacement and deformations, during continuous burial and subsequent tectonic deformations.

Talc-graphite schist (TGSH) is a natural organo-mineral complex that was derived from the regional metamorphism of organic matter-bearing calcareous clays under the lowest temperature and pressure of the green schist facies (573–632 K and 1–3 Kbars, respectively). The application of TGSH that is widely available in the Meatiq area (Eastern Desert, Egypt) was investigated for the first time ever in the remediation of methylene blue dye (MB) from aqueous solutions. The characterization of the TGSH was carried out using various techniques (XRF, XRD, SEM, FT-IR and BET surface area), and its MB removal capacity was estimated at different experimental conditions. The MB adsorption by TGSH was time- and pH-dependent process, where 120 min was sufficient enough to attain equilibrium. The MB adsorption capacity by the TGSH was directly proportional to the applied temperature, confirming that the MB adsorption process was endothermic in behavior. Based on the determination coefficients, the pseudo-second-order equation (R2= 0.939) explained MB adsorption data better than the first-order one (R2= 0.653). Meanwhile, intra-particle diffusion was not the sole controlling rate in MB removal by the TGSH. Moreover, the nonlinear regressions of Langmuir model (R2= 0.876) explained the equilibrium data better than the other applied models (Temkin, R2= 0.793, and Freundlich, R2= 0.752). On the other hand, the estimated qmax(maximum removal capacity) of Langmuir was 9.41 mg/g at ambient temperature. Hydrogen bonding and electrostatic interaction were the governing mechanisms of MB removal by TGSH with variable impact in accordance with the prevailing pH condition.

Some reactions of 6‐substituted‐1,2,4‐triazines of type (I) are described.