1. Long-term efficacy and safety of a new olive oil-based intravenous fat emulsion in pediatric patients: a double-blind randomized study
- Author
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Goulet, Olivier, de Potter, Sophie, Antebi, Helena, Driss, Fathi, Colomb, Virginie, Bereziat, Gilbert, Alcindor, Louis-Gerald, Corriol, Odile, Le Brun, Alexia, Dutot, Guy, Forget, Dominique, Perennec, Veronique, and Ricour, Claude
- Subjects
Lipids -- Health aspects ,Fat emulsions -- Evaluation ,Parenteral feeding -- Composition ,Food/cooking/nutrition ,Health - Abstract
Background: A new intravenous lipid emulsion (ILE) prepared from a mixture of soybean and olive oils contains only long-chain triacylglycerols, with a low proportion (20%) of polyunsaturated fatty acids and 60% monounsaturated fatty acids. Objective: The goal of this randomized, double-blind clinical trial was to assess in children the efficacy and safety of this new ILE compared with a control group receiving a soybean-oil emulsion. Design: Eighteen children received for 2 mo 24% of nonprotein energy (1.80 g [multiplied by] kg [multiplied by] [sup.-1] [multiplied by] [d.sup.-1]) either as the new ILE or a soybean oil-based emulsion. Assessments were performed on days -30, 0, 30, and 60 and the changes (day 60 - day 0) assessed by analysis of variance. Results: There were no significant differences in triacylglycerol, apolipoproteins A-I and B, or HDL cholesterol between the 2 groups, whereas total and LDL cholesterol were higher in the soybean oil group on day 60. The pattern of 20:4n-6 in erythrocyte membranes did not change significantly, nor did the ratio of 20:3n-9 to 20:4n-6. On day 60, 18:1n-9 was significantly higher in the olive oil group, the ratio of [Sigma]n-6 [is greater than] [C.sub.18] + 18:3n-6 to 18:2n--6 was 2.20 [+ or -] 0.09 in the olive oil group and 1.33 [+ or -] 0.16 in the soybean-oil group, and [Sigma]n-3 [is greater than] [C.sub.18] was 3.83 [+ or -] 0.30 in the olive oil group and 4.03 [+ or -] 0.33 in the soybean-oil group. The peroxidation index was lower after the olive oil treatment. Conclusions: The olive oil-based emulsion was well tolerated, maintained a normal EFA status, and may be more suitable for prevention of lipid peroxidation than the soybean-oil-based emulsion. Am J Clin Nutr 1999;70:338-45. KEY WORDS Intravenous fat emulsion, lipids, olive oil, soybean oil, parenteral nutrition, pediatrics, children
- Published
- 1999