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Alkalization changes the physicochemical, bioactive, and powder flow properties of cocoa powders, so it is an essential factor affecting the quality of cocoa products. This study investigated the relationship of the alkalization process with physicochemical properties such as color, pH, and bioactive properties such as total phenolic, flavonoid, and antioxidant capacity of cocoa powders. For this purpose, natural cocoa powders were alkalized using sodium hydroxide (NaOH) or potassium carbonate (K2CO3), or potassium hydroxide (KOH) solutions at their different concentrations. The browning index, darkness, and pH values increased while the total phenolic content, flavonoid, and antioxidant capacity decreased depending on the type of alkali used. FTIR spectra revealed changes in the stretching vibrations in the molecular structure of alkalized cocoa powders. Even though the alkalization process did not affect the microstructure of cocoa particles visibly, treatment with different alkali agents altered the thermal behavior, compressibility and caused a decrease in the powder flowability.

There are many harmful chemicals in the wood protection and coating industry. These substances adversely affect human health over time and cause many diseases such as respiratory tract, skin, or lung cancer over time. In this study, bio-based nano-coatings as a replacement of bisphenol-A (BPA) were prepared by both protecting the wood organically and trying to prevent applications that would adversely affect human health. This study was aimed to improve wood properties such as oven and air-dry densities and water absorption (WA) from physical properties, color, gloss, and roughness from surface properties after natural weathering, and compression strength parallel to the grain (CSPG) from mechanical properties by coating these materials on Oriental beech wood. New bio-based epoxide–amine (EP) coatings were preferred over BPA material and their nano-composite coating derivatives including fullerenes, graphene, and carbon nanotubes were prepared by reactions of epoxy-functionalized tung. A diamine hardener (isophorone diamine) and epoxide tung oil (ETO) doped with nanoparticles were cured, and their physical properties were also determined. Consistent with our previous work, glycidyl methacrylate and tung oil were preferred to form epoxy-functionalized tung oil (ETO) by opting for a Diels–Alder reaction. The new bio-based epoxide–amine-cured systems were created at ambient temperature using a 1:1 epoxy-to-amine molar ratio. The specimens covered with epoxide nano-composites exhibited greater water resistance than the control group. When the surface properties of the epoxy nano-composite-coated specimens after weathering were examined, a more stable color change was observed compared to the control group. Furthermore, while the glossiness of the epoxide nano-composite-coated specimens decreased more than the control group, their roughness increased more. CSPG of epoxy-coated specimens increased a little bit compared to the control group, but no statistical difference was found.

At the first interim analysis of the phase 3 ENGOT-cx11/GOG-3047/KEYNOTE-A18 study, the addition of pembrolizumab to chemoradiotherapy provided a statistically significant and clinically meaningful improvement in progression-free survival in patients with locally advanced cervical cancer. We report the overall survival results from the second interim analysis of this study.

Jelly candies are soft confectionery products primarily composed of sucrose, corn syrup and gelling agents. This study investigates the impact of six different corn syrup, all used at constant amount (46.22%), on the physicochemical (moisture content, pH, Colour), texture and sensory properties of gelatin-based jelly samples. The Moisture content, pH, colour, and texture properties of samples were analysed at 0th, 15th, 30th, 45th, and 60th day during storage. Before storage moisture content of the candiesranged from21.03 to 22.57% whereas after 60 days, it was found between 19.31 and 20.72%. Sample JF42 exhibited the least moisture rate loss. The type of corn syrup did not significantly affect the pH of the samples. Samples with higher fructose content in the corn syrup had the lowest hardness, whereas the sample with the highest maltose content exhibited the highest hardness. Changes in gumminess and chewiness paralleled variations in hardness results. Hardness and gumminess were found suitable to follow up gelatin-based samples storage using the zero-order kinetics modelling. Corn syrups with high fructose amounts intensified the redness, while those with high glucose levels led to yellowness in the candies. In sensory evaluation, products made with G40, G60, and M50 corn syrups received higher general Understanding how various types of corn syrup impact the candies quality helps producers optimize their formulation. This information enables producers to mitigate quality deterioration during storage, ensuring that their candies maintain at the desired level and appeal to consumers.

AbstractThe main objective of this study was to investigate the effect of insulin on drone semen quality after cryopreservation. Semen samples were obtained from sexually mature drones. The semen samples were pooled and diluted with varying concentrations of insulin lispro, specifically 5 IU (I-5), 10 IU (I-10), 15 IU (I-15), and 20 IU (I-20), as well as a control. The assessment of motility, plasma membrane integrity and DNA integrity was conducted using microscopy. Flow cytometry was used to assess acrosome integrity, mitochondrial membrane potential, and nitric oxide level. The preservation of motility, plasma membrane functional integrity, and acrosome integrity was significantly superior in the I-5 group compared to the control group. However, increasing levels of insulin had a detrimental impact on the integrity of the acrosome in both the I-15 and I-20 groups. The mitochondrial membrane potential was significantly elevated in the I-5 and I-10 groups compared to the control group. However, a statistically significant decrease was observed in both the I-15 and I-20 groups. We observed a significant decrease in nitric oxide levels in both the I-5 and I-10 groups as compared to the control group. The preservation of DNA integrity was significantly higher in the insulin containing groups compared to the control group. The study findings revealed that the inclusion of insulin lispro in drone semen extenders yielded beneficial outcomes for drone semen.

ABSTRACTIntercropping is an agricultural technique where many crops are grown together on the same field, and it is becoming more widely acknowledged for its ability to improve productivity in food and forage production. This farming method allows for the strategic integration of a profitable crop with cover or non-profitable crops to achieve reciprocal benefits, while also spreading advantages across different agricultural systems. Intercropping designs differ to attain greater crop yields, reduce the use of chemicals and fertilizers, and enhance water-use efficiency, especially in the demanding circumstances of arid and semi-arid countries. This study examines new mechanisms via which intercropping enhances sustainable agriculture, including recent progress in ecological, genetic, and microbial interactions that enhance plant growth and resilience. The adaptability of the Mediterranean region, for varied agricultural methods is also assessed, with a particular focus on the possibilities for implementing intercropping systems. This study provides a thorough analysis of existing research, emphasizing the many advantages of intercropping and its contribution to the progress of sustainable agriculture.

To evaluate results of sutured repair for slipping rib syndrome (SRS), identify failure points, and discuss technique modifications to improve outcomes through costal margin reconstruction (CMR).

Many disease processes demonstrate both dermatologic and radiologic findings. Through improved understanding of these manifestations, we can improve our diagnostic abilities and collaborate more effectively with clinicians. Part 1 of this review covers classic dermatologic and radiologic findings of disease processes, categorized as infectious diseases, neoplastic disorders, and genetic syndromes. Part 2 focuses on inflammatory disorders and arthritides. Although the list of disease processes with dermatologic and radiologic findings is extensive, this review focuses on a collection of diseases, which are either common or with particularly classic and notable manifestations. With a heightened understanding of these manifestations, radiologists can more effectively guide clinicians in ordering appropriate radiologic examinations, and together can efficiently arrive at accurate diagnoses for our patients.

IMPORTANCE: The KEYNOTE-826 randomized clinical trial showed statistically significant and clinically meaningful survival benefits with the addition of pembrolizumab to chemotherapy with or without bevacizumab in patients with persistent, recurrent, or metastatic cervical cancer. Treatment effects in patient subgroups of the study population are unknown. OBJECTIVE: To assess efficacy outcomes in patient subgroups of KEYNOTE-826. DESIGN, SETTING, AND PARTICIPANTS: Exploratory subgroup analyses were conducted in a global, phase 3, randomized, double-blind, placebo-controlled clinical trial. Participants included women with persistent, recurrent, or metastatic adenocarcinoma, adenosquamous carcinoma, or squamous cell carcinoma of the cervix that had not been treated with systemic chemotherapy and was not amenable to curative treatment. This subanalysis was conducted from November 20, 2018, to May 3, 2021. INTERVENTIONS: Pembrolizumab, 200 mg, every 3 weeks or placebo for up to 35 cycles plus chemotherapy (paclitaxel, 175 mg/m2, plus cisplatin, 50 mg/m2, or carboplatin AUC 5 [area under the free carboplatin plasma concentration vs time curve]) with or without bevacizumab, 15 mg/kg. MAIN OUTCOMES AND MEASURES: Overall survival (OS) and progression-free survival (PFS) by investigator assessment per Response Evaluation Criteria in Solid Tumors version 1.1 in subgroups defined by use of bevacizumab (yes or no), choice of platinum (carboplatin or cisplatin), prior chemoradiotherapy (CRT) exposure only (yes or no), and histologic type (squamous or nonsquamous) in patients with programmed cell death ligand 1–positive tumors (defined as a combined positive score [CPS] ≥1) and in the intention-to-treat population. RESULTS: A total of 617 patients (median age, 51 years; range, 22-82 years) were enrolled in the trial. In the CPS greater than or equal to 1 population, hazard ratios (HRs) for OS favored the pembrolizumab group in all subgroups: with bevacizumab (HR, 0.62; 95% CI, 0.45-0.87) and without bevacizumab (HR, 0.67; 95% CI, 0.47-0.96), use of carboplatin (HR, 0.65; 95% CI, 0.50-0.85) and cisplatin (HR, 0.53; 95% CI, 0.27-1.04), with prior CRT only (HR, 0.56; 95% CI, 0.39-0.81) and without prior CRT only (HR, 0.72; 95% CI, 0.52-1.00), and squamous (HR, 0.60; 95% CI, 0.46-0.79) and nonsquamous (HR, 0.70; 95% CI, 0.41-1.20) histologic type. In the intention-to-treat population, HRs for OS also favored the pembrolizumab group in all subgroups: with bevacizumab (HR, 0.63; 95% CI, 0.47-0.87) and without bevacizumab (HR, 0.74; 95% CI, 0.53-1.04), use of carboplatin (HR, 0.69; 95% CI, 0.54-0.89) or cisplatin (HR, 0.59; 95% CI, 0.32-1.09), with prior CRT only (HR, 0.64; 95% CI, 0.45-0.91) and without prior CRT only (HR, 0.71; 95% CI, 0.53-0.97), and squamous (HR, 0.61; 95% CI, 0.47-0.80) and nonsquamous (HR, 0.76; 95% CI, 0.47-1.23) histologic type. Similar to OS, the addition of pembrolizumab prolonged PFS across all subgroups in the CPS greater than or equal to 1 and intention-to-treat populations. CONCLUSIONS AND RELEVANCE: The findings of this trial suggest that adding pembrolizumab to chemotherapy with or without bevacizumab improved OS across subgroups of patients with persistent, recurrent, or metastatic cervical cancer. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03635567

With large wildfires becoming more frequent1,2, we must rapidly learn how megafires impact biodiversity to prioritize mitigation and improve policy. A key challenge is to discover how interactions among fire-regime components, drought and land tenure shape wildfire impacts. The globally unprecedented3,42019–2020 Australian megafires burnt more than 10 million hectares5, prompting major investment in biodiversity monitoring. Collated data include responses of more than 2,000 taxa, providing an unparalleled opportunity to quantify how megafires affect biodiversity. We reveal that the largest effects on plants and animals were in areas with frequent or recent past fires and within extensively burnt areas. Areas burnt at high severity, outside protected areas or under extreme drought also had larger effects. The effects included declines and increases after fire, with the largest responses in rainforests and by mammals. Our results implicate species interactions, dispersal and extent of in situ survival as mechanisms underlying fire responses. Building wildfire resilience into these ecosystems depends on reducing fire recurrence, including with rapid wildfire suppression in areas frequently burnt. Defending wet ecosystems, expanding protected areas and considering localized drought could also contribute. While these countermeasures can help mitigate the impacts of more frequent megafires, reversing anthropogenic climate change remains the urgent broad-scale solution.

Breast and gynecologic cancers are common across the world and are associated with substantial societal and economic burden. Pembrolizumab was among the first immune checkpoint inhibitors targeting programmed cell death protein 1 to be approved for the treatment of patients with triple-negative breast cancer, cervical cancer, and endometrial cancer. Recent clinical trials have established pembrolizumab regimens as a standard of care treatment for these tumor types. Clinical data are further supported by patient-reported outcome, cost-effectiveness, and real-world evidence. Pembrolizumab monotherapy and combination regimens do not negatively influence health-related quality of life and are cost-effective relative to comparators. Ongoing phase 3 studies with pembrolizumab will expand the current understanding of its use in breast and gynecologic cancers. Several of these studies are in patients with early-stage disease with the hope of curing patients. The main objective of this review is to summarize the clinical, humanistic, and economic value of pembrolizumab in these settings and to describe the future challenges for patients, caregivers, clinicians, and payers.

Abstract:Vladimir Nabokov's pre-war Russian language short stories were translated into English, whether by his son Dmitri or by others, but, in the novelist's lifetime, always "in collaboration with the author." The extent of this collaboration sometimes amounts to self-translation, that is, not to improving the text but to changing its details, the way a translator has no right to do while the author is entitled to revisions. Most often such changes were made in the awareness of the horizons of the new audience; but they also reflect modified attitudes to the material and suggest which meanings it was important for Nabokov to emphasize and which it was important for him to preclude. We discuss such traces of self-translation in three of Nabokov's short stories. The changes made in the 1973 "Torpid Smoke" ("Tyazhyolyy dym," 1935) help to set the story in the times of the Weimar republic rather than after the Nazi 1933 takeover of power, thus forestalling interpretations that could compete with the main theme. The changes in the 1976 "Details of a Sunset" (original published as "Katastrofa" in 1924) enhance the valorization of joy, confronting the wide-spread stigma on the sense of happiness as silly. The changes made in the 1947 "Spring in Fialta" (the original published in 1938) are, however, more closely associated with Nabokov's current concerns, in the period of translation, rather than with those in the year of composition.

In this study, the focus is placed on addressing the challenge posed by the time-consuming nature of experimental methods employed for the determination of the hydraulic conductivity function (HCF) in unsaturated soil. Instead, preference is given to transient inflow/outflow experiments utilizing the axis translation technique. Within this framework, the flow through specimens inside a suction-controlled oedometer is modeled as a one-dimensional unsaturated seepage problem, with consideration of ceramic impedance. The impact of suction-induced volume change on unsaturated flow is incorporated into the numerical model. A novel approach for estimating internodal conductivities in numerical simulations is introduced. The transient variation of soil water mass is monitored to collect time-series water content data. This data, in conjunction with a 1-D seepage model, are used to estimate the hydraulic conductivity function. The implementation of the numerical model is straightforward, and a spreadsheet can be employed for this purpose. Importantly, the experimental setup requires no special or expensive equipment beyond what is commonly used in unsaturated soil testing. To validate the proposed numerical model, experiments were conducted on various soil types, including poorly graded sand, non-plastic silt, and highly plastic clay. The predictions are subsequently validated against data obtained from existing, sophisticated HCF determination techniques, affirming the method’s effectiveness for estimating the hydraulic conductivity function in unsaturated soils.

In this particular study, the researchers conducted energy and exergy analyses of a solar-based transcritical CO2Rankine cycle in order to improve its performance by integrating a regenerator and an energy storage unit. For the assessment, the system's features are drawn from genuine experimental research undertaken at Doshisha University in Kyoto, Japan. The effects of employing a regenerator and an energy storage tank were examined theoretically in order to determine the potential for enhancing the performance of the cycle. According to the data analysis, there has been a substantial boost in the energy produced, registering an impressive 22.7% improvement.

This work examined the changes in surface characteristics of Oriental beech (Fagus orientalisL.) covered with vegetable oil-based epoxide-amine (ETO + D230) and its nanocomposite derivatives Epoxy + amine + carbon nanotube (ETO + D230 + C), Epoxy + amine + fullerene (ETO + D230 + F), and Epoxy + amine + graphene (ETO + D230 + G) doped with carbon nanoparticles following weathering. Results showed that while all coated groups displayed good lightness stability following weathering, the non-coated (control) group produced negative lightness stability values. The coated Oriental beech had greater overall color stability than the uncoated (control) group. The specimens coated with ETO + D230 + C nanocomposite exhibited the best color stability. All uncoated and coated specimens produced negative a*and positive b*values, indicating a propensity to turn greenish or yellowish after weathering, respectively. After weathering, while the surface roughness values of all specimens increased, their gloss decreased. In addition, after weathering, all coated samples had less gloss loss and lower surface roughness than the control group. Our findings show that following weathering, Oriental beech coated with ETO + D230 + C, ETO + D230 + F, and ETO + D230 + G nanocomposites have better surface properties than ETO + D230-coated Oriental beech.

In this study, probiotic soft jelly candy was developed using Bacillus coagulans, Bacillus clausiiand Bacillus subtilisas probiotics and the rheological, textural, microbiological and sensory characteristics of jellies were determined. In terms of probiotic features, the viability and in vitro gastrointestinal tract (GIT) durability of probiotics were determined during 3 months of storage. No alteration in the physicochemical properties of the soft candies was observed with the usage of probiotics (p > 0.05) in comparison to the control samples. Utilization of the probiotic strains resulted in the increment of the total phenolic content and antioxidant capacities of soft candies. The flow behavior characteristics of the soft candies did not change with the addition of probiotics and they showed similar viscosity values. Jelly candies (P1, P2, EG and BB2) containing strains of Bacillus subtilis, Bacillus coagulansand Bacillus clausiipreserved their probiotic properties until the end of the 90th day as the Bacillusnumbers were higher than 6 log cfu/g. In the in vitro GIT test, the survival rate of Bacillusstrains was over 90.36% at the end of the storage period. The produced probiotic jelly candies presented desired sensorial acceptability. These findings revealed that using of probiotic Bacillusstrains is excellent alternative for production of functional confectionery.

ABSTRACTObjectiveTo screen psychological problems of patients with obstructive sleep apnea syndrome (OSAS) by utilizing the psychological symptom screening test Symptom Checklist-90-Revised (SCL-90-R) and to evaluate the effect of continuous positive airway pressure (CPAP) treatment.MethodsThe SCL-90-R and Epworth Sleepiness Scale (ESS) test were applied to 66 patients with Apnea-Hypopnea Index (AHI ≥ 30/h) using CPAP device and 20 healthy individuals; the test results were compared.ResultsThe age of the patients ranged from 28 to 67 years, and the patient group comprised 54 males (81.8%) and 12 females (18.2%). The AHI scores ranged from 30.05 to 99.80, with a mean of 49.34 ± 21.40. Significant improvement was seen in 6 of the 11 SCL-90-R scores in CPAP-treated patients.ConclusionThe authors conclude that the SCL-90-R test may be appropriate for evaluating the response to CPAP treatment in OSAS patients and monitoring the psychosocial effects of treatment.

This study aimed to determine the relationship between scoliosis and risk of developing complications in patients who underwent gastrostomy. Patients who underwent percutaneous endoscopic gastrostomy (PEG) or surgical gastrostomy (SG) between 2012 and 2022 were included. Leakage, discharge, granuloma, and hyperemia were considered minor complications, while visceral injury, ileus, and re‐do surgery were considered major complications. The degree of scoliosis was calculated using the Cobb angle. The SG and PEG groups were compared by evaluating the complications and their correlation with scoliosis. A total of 104 patients with a mean age of 5.0 ± 5.3 were included; 58% of patients were treated with SG. Patients in the SG group were younger (P< 0.001). Minor complications were significantly more common in the PEG group (P= 0.018). There was no difference between the groups in terms of major complications (P= 1.000). Scoliosis was observed in 32.7% of the patients (n = 34). In the SG group, no correlation was found between the Cobb angle and the frequency of minor (P= 0.173) or major complications (P= 0.305). There was no significant difference between the Cobb angles of patients with and without minor complications in the PEG group (P= 0.478); the Cobb angles of patients with major complications (75°) were significantly higher than those without (36°) (P= 0.030). Gastrostomy is important for weight gain and nutritional needs of children. This study showed that the risk of complications in SGs did not correlate with the degree of scoliosis and that the risk of major complications in PEGs increased in patients with a high degree of scoliosis.

Myotonia congenita is the most common form of nondystrophic myotonia and is caused by Mendelian inherited mutations in the CLCN1gene encoding the voltage-gated chloride channel of skeletal muscle. The study aimed to describe the clinical and genetic spectrum of Myotonia congenita in a large pediatric cohort. Demographic, genetic, and clinical data of the patients aged under 18 years at time of first clinical attendance from 11 centers in different geographical regions of Türkiye were retrospectively investigated. Fifty-four patients (mean age:15.2 years (±5.5), 76% males, with 85% Becker, 15% Thomsen form) from 40 families were included. Consanguineous marriage rate was 67%. 70.5% of patients had a family member with Myotonia congenita. The mean age of disease onset was 5.7 (±4.9) years. Overall 23 different mutations (2/23 were novel) were detected in 52 patients, and large exon deletions were identified in two siblings. Thomsen and Becker forms were observed concomitantly in one family. Carbamazepine (46.3%), mexiletine (27.8%), phenytoin (9.3%) were preferred for treatment. The clinical and genetic heterogeneity, as well as the limited response to current treatment options, constitutes an ongoing challenge. In our cohort, recessive Myotonia congenita was more frequent and novel mutations will contribute to the literature.

In 'Unnatural Narrative Theory,' Brian Richardson calls for expansion of classical narratology to accommodate 'unnatural narratives.' Perhaps this should be done by interface with other discursive formations, including discourse analysis, [...]

Free Gingival Graft (FGG) is a widely used surgical method to increase the amount of attached keratinized gingiva and to achieve certain amounts of root surface coverage.

Purpose: To investigate small nerve fibre damage and inflammation at the level of the sub-basal nerve plexus (SNP) of severe obese patients and compare the results with those of healthy subjects. Methods: This cross-sectional, observational study investigated the data of 28 patients (14 out of 28 prediabetic or diabetic) with severe obesity (Body Mass Index; BMI ≥ 40) and 20 healthy subjects. Corneal nerve fibre density (CNFD), branch density (CNBD), fibre length (CNFL), nerve fibre area (CNFA), nerve fibre width (CNFW), and nerve fractal dimension (CNFrD) and dendritic cell (DC) density were evaluated using in vivo confocal microscopy (IVCM, Heidelberg Retinal Tomograph III Rostock Cornea Module). Automatic CCMetrics software (University of Manchester, UK) was used for quantitative analysis of SNP. Results: Mean age was 48.4±7.4 and 45.1 ± 5.8 in the control and obese group, respectively (p= 0.09). Mean BMI were 49.1 ± 7.8 vs. 23.3 ± 1.4 in obese vs. control group, respectively (p&lt; 0.001). Mean CNFD, CNBD, CNFL, CNFA, CNFW were significantly reduced in obese group compared with those in the control group (always p&lt; 0.05, respectively). There were no significant differences in any ACCMetrics parameters between prediabetic/diabetic and non-diabetic obese patients. Increased DC densities were detected in obese group compared with those in control group (p&lt; 0.0001). There were significant correlations between BMI scores and SNP parameters. Conclusion: Imaging with IVCM is a feasible, non-invasive method to detect and quantify occult corneal nerve damage and increased inflammation in patients with obesity. This study suggests that obesity may be a separate risk factor for peripheral neuropathy regardless of DM.

Christa Schonfelder. Wounds and Words: Childhood and Family Trauma in Romantic and Postmodern Fiction. Bielefeld, Germany: transcript Verlag, 2013. 345 pp. Both in terms of the literary materials analyzed and [...]

In the context of the varied uses of hypallage in poetry and fiction, this paper discusses hypallage as 'epithet transfer' in Dickens's A Tale of Two Cities. Pointing to an overlap of 'epithet transfer' with metaphor, metonymy, personification, and enthymeme, as well as to its difference from such tropes, the paper analyzes the local effects of this form of hypallage and comments on its general effect as reducing the mechanical constituent of the reading process (Herbert Spencer) while creating the conditions for a prolonged aesthetic lingering on detail (Victor Shklovsky). It goes on to show that, in addition to serving as a short-cut conceptual blend, useful in addressing the audience familiar with the history of the French Revolution, in A Tale of Two Cities 'epithet transfer' is aesthetically appropriate to the novel's pattern of the transfer of fate--bestowing on one character the fate that logical determinacies are expected to reserve for another., One of the reasons for the famously 'inimitable' quality of Dickens's style is its oscillation between the literal and the figurative uses of vocabulary. Dickens's texts are monuments to the [...]

ABSTRACTThis study explores the reflection of WhatsApp groups, one of the most popular means of communication style, between school principals and teachers upon teachers’ professional lives. The research was designed using a qualitative model, and semi-structured interviews were used for data collection. The research group consisted of 26 teachers from primary and secondary schools. The data were analysed and interpreted according to themes. The results showed that some school principals with an autocratic leadership style used WhatsApp excessively and inappropriately, putting unnecessary pressure on their subordinates. Overall, the study highlights the importance of considering the impact of instant messaging on teachers when using WhatsApp in schools. The findings provide valuable insight into the influences of instant messaging on professional and personal lives and suggest a balance between the two to avoid detrimental effects on teachers’ well-being.

Determinar las prácticas para aumentar la leche materna utilizadas por los profesionales de la salud con sus hijos y sus recomendaciones a las madres.

The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atherosclerosis. The aim of our study is to determine the relationship, between serum DcR3 levels and inflammatory markers in patients with renal transplantation, those receiving dialysis treatment and cases with chronic renal failure that did not receive replacement therapy, and to evaluate their correlation with USG findings.

Diagnostic errors in medicine represent a significant public health problem but continue to be challenging to measure accurately, reliably, and efficiently. The recently developed Symptom-Disease Pair Analysis of Diagnostic Error (SPADE) approach measures misdiagnosis related harms using electronic health records or administrative claims data. The approach is clinically valid, methodologically sound, statistically robust, and operationally viable without the requirement for manual chart review. This paper clarifies aspects of the SPADE analysis to assure that researchers apply this method to yield valid results with a particular emphasis on defining appropriate comparator groups and analytical strategies for balancing differences between these groups. We discuss four distinct types of comparators (intra-group and inter-group for both look-back and look-forward analyses), detailing the rationale for choosing one over the other and inferences that can be drawn from these comparative analyses. Our aim is that these additional analytical practices will improve the validity of SPADE and related approaches to quantify diagnostic error in medicine.

This study presents the shape memory behavior of Ni-rich NiTi shape memory alloy fabricated by Laser Powder Bed Fusion Additive Manufacturing (L-PBF-AM) before and after post-processing heat treatment. The microstructural features and thermo-mechanical responses were systematically investigated to understand the effects of processing on the behavior of the specimens. It was shown that the L-PBF-AM process improves the functionality of NiTi components by illustrating perfect superelastic behavior at higher-temperature windows compared to the casted ingot. In addition, it was revealed that shape memory responses were tailored by altering hatch distance, which significantly controls the texture formation along the building direction. After post-processing treatments, transformation temperatures were increased, hysteresis was decreased, and the strength of the samples was significantly improved. The aged L-PBF-AM sample with a smaller hatch distance (80 µm) and intense [001] texture illustrated perfect superelastic behavior with a recoverable strain of 7% and a superelastic temperature span of about 100 °C.

Mucilage, which is the main component of the taro plant, and is known to have significant health benefits, has become a versatile ingredient in the food industry due to its richness in fiber and protein and its unique rheological properties. Taro mucilage has a rich content of various bioactive chemicals such as saponins, tannins, flavonoids, and phenolic acids along with being viscous and water-soluble. The effective use of taro mucilage is only possible if it is efficiently extracted, which has created a pre-treatment or additional treatment requirement. Temperature application plays a crucial role in taro mucilage extraction and significantly affects its composition, yield, and quality. This present study focuses on the effects of different temperatures (20, 40, 60 and 80 °C) applied during taro mucilage extraction on physicochemical and rheological properties. The water-holding capacity of taro mucilage samples decreased significantly (p < 0.05) from 0.48 to 0.12% with a rise in temperature while there is no significant linear decrease or increase in oil-holding capacity and solubility values. Emulsifying activity and emulsion stability parameters significantly improved by increasing temperature (p < 0.05). The zeta potential ranged from − 10.49 to − 24.09 so stable emulsions were formed. At higher temperatures, lighter mucilage was obtained for both the powder and aqueous form of mucilage. The samples showed pseudoplastic behavior and the temperature increased the Kvalue up to 60 °C.

Hyperspectral imaging has a critical role in observing the Earth's surface, providing images with rich spectral information. As a result, it has become an essential tool for monitoring and addressing environmental issues such as pollution, water balance, and climate change. Among these challenges, marine pollution poses a significant ecological threat, as evidenced by the recent mucilage incident in Turkey in April 2021. Mucilage, a dense mucus-like substance resulting from the overgrowth of marine plankton and microorganisms, detrimentally affects marine ecosystems when its levels surge. Traditional mucilage detection involves labour-intensive sampling and laboratory analysis, rendering it impractical for vast marine environments. Remote sensing techniques offer a promising alternative for automated mucilage detection from satellite imagery. In this study, we propose a multi-scale superpixel-based classification approach for mucilage detection, using the PRISMA satellite's hyperspectral mucilage datasets captured over the Sea of Marmara. Our method performs classification by analyzing the closeness between the subspace spanned by the samples in the superpixel and the subspace spanned by the within-class training samples. We formulate the solution to this approach via a Canonical Correlation Analysis framework and show that our proposed method outperforms its competitors, especially when the training data is limited. Our comprehensive experiments include assessing the transferability of classification methods on datasets collected from different locations and at different times. We compared the performance of our proposed method with state-of-the-art spectral-spatial classification methods, including deep learning-based random patches network (RPNet), structural-kernel collaborative representation (SKCR), and window based nearest subspace classifier (WBNSC). The results show that the proposed method outperforms existing techniques in most cases. The datasets and source code are publicly available on GitHub at https://github.com/kgtoker/MSBNSC , enabling more comprehensive access and collaboration in environmental monitoring efforts. • Enhances mucilage detection performance with a novel multi-scale superpixel based classifier. • Outperforms competitors in scenarios with limited training samples. • Provides insights through cross-dataset evaluation experiments from different locations and times. • Contributes to marine ecosystem protection efforts. [ABSTRACT FROM AUTHOR]

Inadequate keratinized gingiva around the implant can lead to poor oral hygiene, plaque accumulation, gingivitis, bleeding on probing, gingival recession, and alveolar bone loss. It is important to protect the tissues around the implant.

Gingival hyperpigmentation usually occurs due to abnormal melanin deposition in the gingiva, resulting in an unaesthetic black appearance. In this case report, the treatment of a patient, who presented to our clinic with aesthetic concerns due to melanin hyperpigmentation in the maxillary and mandibular anterior gingiva, with different types of lasers and conventional surgery will be presented and treatment methods will be compared.

Tracheobronchomalacia (TBM) in adults is typically managed conservatively with positive airway pressure therapy or stents.

Both intraspecific and interspecific crosses are a well‐known breeding strategies to generate variations or assemble desirable traits in economically important plants. Interspecific crosses have been mined to improve resistance to (a)biotic stresses in chickpea (Cicer arietinumL.) in a limited number of research studies but have never been crosschecked for yield and yield criteria in intraspecific versus interspecific crosses. Comparison of superior progeny or superior recombinant inbred lines (RILs) and better progeny than their best parent for yield, yield criteria, and resistance to (a)biotic stresses in intraspecific versus interspecific crosses was the objectives of this study. Also, associations between superior progeny and genetic distance based on simple sequence repeat (SSR) markers were assessed among annual Cicerspecies including cultivated chickpea, C. reticulatumLadiz. and C. echinospermumP.H. Davis. Each two genotypes of C. reticulatumand C. echinospermumwere crossed with three genotypes of cultivated chickpea. Not only superior progeny for yield and yield criteria, but also superior RILs that were cold tolerant were detected higher in interspecific crosses than in intraspecific crosses. On the other hand, plant height, first pod height, and seed size were higher in intraspecific crosses than in interspecific crosses, indicating that seed size and traits suitable for combine harvest can be increased via intraspecific crosses. A significant association was found between superior progeny and genetic distance among Cicerspecies. It was concluded that interspecific crosses in Cicerspecies may increase yield and resistance to (a)biotic stresses, whereas intraspecific crosses may increase plant height and seed size. Superior progeny found by fruitful heterosis were more common in interspecific crosses.Plant height, first pod height, and seed size can be increased by intraspecific crosses.Wild Cicer species can be used for increasing yield, yield criteria, and resistance to (a)biotic stresses.SSR markers can be preferred to predict fruitful heterosis or superior progeny in chickpea.

ABSTRACT The objective of this study was to determine the effect of heat treatment on bonding strength of the samples from four different species, namely Scotch pine, oriental beech, white [...]

I welcome the idea of 'social minds' as described in Alan Palmer's article as a new tool for literary analysis, but I see it as one tool among many and [...]

Dizziness is the third most common major medical symptom reported in general medical clinics (1) and accounts for about 3%-5% of visits across care settings. (2) In the United States, [...]

Abstract The aim of this study was to determine the effects of ebru, a traditional Turkish art of marbling, on some physical properties of various varnishes. Scots pine (Pinus sylvestris [...]

A study empirically examines the impact of the ongoing presence of currency substitution and exchange rate pass-through in the Turkish economy. Findings suggest that the ongoing presence of currency substitution and exchange rate pass-through could hinder the implementation of a successful monetary policy in Turkey in a flexible exchange rate regime.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ijinfomgt.2009.08.009 Byline: Kaan Varnali, AyAegul Toker Keywords: Mobile marketing; Mobile consumer behavior; Mobile marketing research; Mobile commerce; Mobile business Abstract: Rapid proliferation in the business potential of mobile marketing attracts researchers from various fields to contribute to the growing body of knowledge on the phenomena. Although the literature on mobile marketing is accumulating, the stream of research is still in the development stage, hence is highly inconsistent and fragmented. This paper aims to organize and classify the literature on mobile marketing and assess the-state-of-the-art in order to facilitate future research. The review covers 255 peer-reviewed journal articles from 82 journals published between 2000 and 2008. The resulting framework summarizes the progress in mobile marketing research and provides future research directions. Author Affiliation: Department of Management, BoAazici University, Bebek, 34342 A[degrees]stanbul, Turkey

The cupola of Florence's Duomo is the perfect structure to explain the beginnings of the Italian Renaissance. It symbolizes the moment when a society dreamed of recreating the past--ancient Roman [...]

It has often been said that the great art movement of the Renaissance was built on Roman foundations. Excavations have now proved that that statement is literally correct. For centuries, [...]