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Background: People with opioid use disorder (OUD) are at risk of premature death and can benefit from palliative care. We sought to compare palliative care provision for decedents with and without OUD. Methods: We conducted a cohort study using health administrative databases in Ontario, Canada, to identify people who died between July 1, 2015, and Dec. 31, 2021. The exposure was OUD, defined as having emergency department visits, hospital admissions, or pharmacologic treatments suggestive of OUD within 3 years of death. Our primary outcome was receipt of 1 or more palliative care services during the last 90 days before death. Secondary outcomes included setting, initiation, and intensity of palliative care. We conducted a secondary analysis excluding sudden deaths (e.g., opioid toxicity, injury). Results: Of 679 840 decedents, 11 200 (1.6%) had OUD. Compared with people without OUD, those with OUD died at a younger age and were more likely to live in neighbourhoods with high marginalization indices. We found people with OUD were less likely to receive palliative care at the end of their lives (adjusted relative risk [RR] 0.84, 95% confidence interval [CI] 0.82-0.86), but this difference did not exist after excluding people who died suddenly (adjusted RR 0.99, 95% CI 0.96-1.01). People with OUD were less likely to receive palliative care in clinics and their homes regardless of cause of death. Interpretation: Opioid use disorder can be a chronic, life-limiting illness, and people with OUD are less likely to receive palliative care in communities during the 90 days before death. Health care providers should receive training in palliative care and addiction medicine to support people with OUD., Between 1990 and 2016, the number of people with opioid use disorder (OUD) worldwide increased from 18.2 million to 26.8 million people. (1,2) As this population ages, more people with [...]

Background: Medical assistance in dying (MAiD) was legalized in Canada in 2016, but coordination of MAiD and palliative and end-of-life care (PEOLC) services remains underdeveloped. We sought to understand the perspectives of health leaders across Canada on the relationship between MAiD and PEOLC services and to identify opportunities for improved coordination. Methods: In this quantitative study, we purposively sampled health leaders across Canada with expertise in MAiD, PEOLC, or both. We conducted semistructured interviews between April 2021 and January 2022. Interview transcripts were coded independently by 2 researchers and reconciled to identify key themes using content analysis. We applied the PATH framework for Integrated Health Services to guide data collection and analysis. Results: We conducted 36 interviews. Participants expressed diverse views about the optimal relationship between MAiD and PEOLC, and the desirability of integration, separation, or coordination of these services. We identified 11 themes to improve the relationship between the services across 4 PATH levels: client-centred services (e.g., educate public); health operations (e.g., cultivate compassionate and proactive leadership); health systems (e.g., conduct broad and inclusive consultation and planning); and intersectoral initiatives (e.g., provide standard practice guidelines across health care systems). Interpretation: Health leaders recognized that cooperation between MAiD and PEOLC services is required for appropriate referrals, care coordination, and patient care. They identified the need for public and provider education, standardized practice guidelines, relationship-building, and leadership. Our findings have implications for MAiD and PEOLC policy development and clinical practice in Canada and other jurisdictions., The relationship between the practice of medical assistance in dying (MAiD) and palliative and end-of-life care (PEOLC) in jurisdictions where both are available has been variable and sometimes tenuous. (1) [...]

Treating humans as partners rather than liabilities in cybersecurity strengthens defenses against modern cyber threats. Traditional approaches often view users as weak links, emphasizing restrictive measures to reduce human error, such as limiting user control or enforcing strict security protocols. However, these methods overlook the potential of empowering users to contribute positively to security efforts. "Enabling approaches," which promote user engagement and motivation, harness human strengths, fostering behaviors that support security rather than merely preventing errors, offering a more holistic, resilient approach to combat evolving cyber threats.

Scott MacDonald 'An Interview with Carolee Schneemann' Afterimage 7, no. 8 (March 1980): 10-11 https://doi.org/10.1525/aft.1980.7.8.10 Scott MacDonald 'North American Avant-Garde Film: A Personal Review' by Scott MacDonald Afterimage 11, no. [...]

The Mystery Writers of America unveiled the nominees for the 2024 Edgar Allan Poe Awards, which honor excellence in the 'mystery, crime, suspense, and intrigue fields.' In the novel category, [...]

IMPORTANCE: Progressive multifocal leukoencephalopathy (PML) is a life-threatening viral infection with no approved antiviral treatment. OBJECTIVE: To determine whether restoring the compromised immune system of patients with PML with directly isolated allogeneic virus–specific (DIAVIS) T cells is a promising therapeutic strategy, especially if other curative options are absent. DESIGN, SETTING, AND PARTICIPANTS: A retrospective case series of patients with PML who were treated with DIAVIS T cells was conducted between March 2020 and February 2022. T cells were isolated from healthy donors within 24 hours and targeted against the BK polyomavirus. Patients with PML were treated monocentrically. Eligibility for treatment with DIAVIS T cells was assessed for patients with confirmed PML, and exclusion criteria included stable PML disease and previous treatment with natalizumab. EXPOSURE: Fresh DIAVIS T cells were administered with a maximum dose of 2 × 104 CD3+ cells/kg body weight. Remaining T cells were cryopreserved in divided doses and administered in additional treatments approximately 2 and 6 weeks later. MAIN OUTCOMES AND MEASURES: Primary outcome measures were clinical response and survival of patients, compared with the outcomes of a historical reference group of PML cases receiving best supportive treatment (BST) and with recently published real-world data of patients with PML who were treated with immune checkpoint inhibition. RESULTS: The study cohort consisted of 28 patients (median [IQR] age, 60 [51-72] years; 20 male [71.4%]). Twenty-two patients (79%) treated with DIAVIS T cells showed response, resulting in significant clinical stabilization or improvement and a reduction in viral load. Six individuals (21%) were classified as nonresponders, deteriorated rapidly, and died, as did 2 other patients during a 12-month follow-up. Older age was the only predictor of a poor treatment response. Survival analysis revealed better 12-month survival rates (hazard ratio, 0.42; 95% CI, 0.24-0.73; P =.02) from diagnosis for patients treated with DIAVIS T cells (18 of 26 [69%]; 12-mo survival rate, 69%) compared with historical controls with BST (57 of 113 [50%]; 12-mo survival rate, including censored data, 45%). CONCLUSION AND RELEVANCE: This case series of DIAVIS T-cell therapy in PML provides first class IV evidence suggesting efficacy to reduce mortality and improve functional outcome. Further prospective studies are required to confirm these results.

Background: Prior investigations have elucidated pathophysiological interactions involving blood coagulation and neurodegenerative diseases. These interactions pertain to age-related effects and a mild platelet antiaggregant function of exogenous α-Synuclein.Objective: Our study sought to explore whether cerebrospinal fluid (CSF) levels of tissue factor (TF), the initiator of the extrinsic pathway of hemostasis, differ between controls (CON) compared to patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), considering that these conditions represent a spectrum of α-Synuclein pathology. We further investigated whether TF levels are associated with longitudinal progression in PD.Methods: We examined CSF levels of TF in 479 PD patients, 67 patients diagnosed with DLB, and 16 CON in order to evaluate potential continuum patterns among DLB, PD, and CON. Of the 479 PD patients, 96 carried a GBA1variant (PD GBA1), while the 383 non-carriers were classified as PD wildtype (PD WT). We considered both longitudinal clinical data as well as CSF measurements of common neurodegenerative markers (amyloid-β 1-42, h-Tau, p-Tau, NfL, α-Synuclein). Kaplan-Meier survival and Cox regression analysis stratified by TF tertile levels was conducted.Results: Higher CSF levels of TF were associated with an older age at examination in PD and a significant later onset of postural instability in PD GBA1. TF levels were lower in male vs. female PD. DLB GBA1exhibited the lowest TF levels, followed by PD GBA1, with CON showing the highest levels.Conclusions: TF as representative of blood hemostasis could be an interesting CSF candidate to further explore in PD and DLB.

Autor(en): Mark Zimmermann Apple hat bekannt gegeben, dass seine iMessage-App ab 2024 den Rich Communication Standard (RCS) unterstützen wird. Könnte sich die Spezifikation damit gegen WhatsApp durchsetzen? Die Spezifikation https://en.wikipedia.org/wiki/Rich_Communication_Services [...]

Autor(en): Mark Zimmermann Mit dem Anfang 2024 beginnenden Zeitalter des Sideloading in der EU droht die Bedeutung des iOS-App-Stores zu schrumpfen. Der Anfang einer Regulierungswelle? Als Apple 2008 den App [...]

Auch weil bislang wenig didaktisches Material zum konfessionell-kooperativen Religionsunterricht vorliegt, kommt es zur Einschätzung dessen Praxis gegenwärtig vor allem darauf an, wie die Lehrpersonen konfessionssensible Lerngelegenheiten arrangieren, wie und ob sie die Schüler:innen zu einer differenzsensiblen Auseinandersetzung stimulieren und was diese im kokoRU lernen. Deshalb werden im vorliegenden Beitrag diesbezüglich die Datenlage zur Praxis im kokoRU bilanziert, einschlägige Einsichten aus der Literatur beschrieben und anschließend Implikationen für die Unterrichtspraxis abgeleitet. Dabei sollte bedacht werden, dass zwar vielfältige empirische Indizien zur Praxis des kokoRU vorliegen, diese jedoch durchgehend auf regional fokussierten Gelegenheitsstichproben beruhen und sich auf einen Zeitraum von 20 Jahren verteilen.

Two trials were performed to evaluate the effect of renal and hepatic impairment on the pharmacokinetics of pritelivir and its metabolites. The renal impairment trial included subjects with mild, moderate, and severe impairment, while the hepatic impairment trial included subjects with moderate impairment. Both trials recruited a matched control group of healthy subjects. Following a single oral dose of 100 mg of pritelivir, mild and moderate renal impairment and moderate hepatic impairment did not have a clinically relevant effect on the pharmacokinetics of pritelivir. In subjects with severe renal impairment, pritelivir exposure (area under the plasma concentration‐time curve from time 0 to infinity (AUC0‐inf) was 57% higher compared with controls. Pritelivir plasma protein binding was similar in subjects and controls with renal impairment, while the free fraction was higher in subjects with moderate hepatic impairment, increasing unbound pritelivir exposure by 23%. For the metabolites pyridinyl phenyl acetic acid (PPA), amino thiazole sulfonamide (ATS), and PPA‐acyl glucuronide, generally higher exposure was observed with increasing degree of renal impairment (ie, moderate to severe), but not with mild impairment. A modest effect of moderate hepatic impairment was observed for PPA and ATS. Pritelivir was safe and well tolerated in healthy subjects and subjects with renal or hepatic impairment.

Sensors are the key to environmental monitoring, which impart benefits to smart cities in many aspects, such as providing real-time air quality information to assist human decision-making. However, it is impractical to deploy massive sensors due to the expensive costs, resulting in sparse data collection. Therefore, how to get fine-grained data measurement has long been a pressing issue. In this article, we aim to infer values at nonsensor locations based on observations from available sensors (termed spatiotemporal inference), where capturing spatiotemporal relationships among the data plays a critical role. Our investigations reveal two significant insights that have not been explored by previous works. First, data exhibit distinct patterns at both long- and short-term temporal scales, which should be analyzed separately. Second, short-term patterns contain more delicate relations, including those across spatial and temporal dimensions simultaneously, while long-term patterns involve high-level temporal trends. Based on these observations, we propose to decouple the modeling of short- and long-term patterns. Specifically, we introduce a joint spatiotemporal graph attention network to learn the relations across space and time for short-term patterns. Furthermore, we propose a graph recurrent network with a time skip strategy to alleviate the gradient vanishing problem and model the long-term dependencies. Experimental results on four public real-world datasets demonstrate that our method effectively captures both long- and short-term relations, achieving state-of-the-art performance against existing methods.

With the popularity of GPS-equipped smart devices, spatial crowdsourcing (SC) techniques have attracted growing attention in both academia and industry. A fundamental problem in SC is assigning location-based tasks to workers under spatial-temporal constraints. In many real-life applications, workers choose tasks on the basis of their preferred trajectories. However, by existing trajectory-aware task assignment approaches, tasks assigned to a worker may be far apart from each other, resulting in a higher detour cost as the worker needs to deviate from the original trajectory more often than necessary. Motivated by the above observations, we investigate a trajectory-aware task coalition assignment (TCA) problem and prove it to be NP-hard. The goal is to maximize the number of assigned tasks by assigning task coalitions to workers based on their preferred trajectories. For tackling the TCA problem, we develop a batch-based three-stage framework consisting of task grouping, planning, and assignment. First, we design greedy and spanning grouping approaches to generate task coalitions. Second, to gain candidate task coalitions for each worker efficiently, we design task-based and trajectory-based pruning strategies to reduce the search space. Furthermore, a 2-approximate algorithm, termed MST-Euler, is proposed to obtain a route among each worker and task coalition with a minimal detour cost. Third, the MST-Euler Greedy (MEG) algorithm is presented to compute an assignment that results in the maximal number of tasks assigned and a parallel strategy is introduced to boost its efficiency. Extensive experiments on real and synthetic datasets demonstrate the effectiveness and efficiency of the proposed algorithms.

The Mott insulator Ca2RuO4exhibits an insulator-to-metal transition induced by d.c. current. Despite the thorough examination of the structural changes associated with this transition, a comprehensive knowledge of the response of electronic degrees of freedom is still lacking. Here we demonstrate current-induced modifications of the electronic states of Ca2RuO4. Angle-resolved photoemission spectroscopy in conjunction with four-probe electrical transport (transport-ARPES) measurements reveal a clear reduction of the Mott gap and a modification in the dispersion of the Ru bands. Based on a free-energy analysis, we show that the current-induced phase is electronically distinct from the high-temperature zero-current metallic phase. Our results highlight strong interplay of lattice- and orbital-dependent electronic responses in the current-driven insulator-to-metal transition.

Famously found written on the blackboard of physicist Richard Feynman after his death was the phrase, “What I cannot create, I do not understand.” From this perspective, recreating the origin of life in the lab is a necessary condition for achieving a deep theoretical understanding of biology. The “metabolism-first” hypothesis is one of the leading frameworks for the origin of life. A complex self-organized reaction network is thought to have been driven into existence as a chemical path of least resistance to release free energy in the environment that could otherwise not be dissipated, rerouting energy from planetary processes to organic chemistry. To increase in complexity, the reaction network, initially under catalysis provided by its geochemical environment, must have produced organic catalysts that pruned the existing flux through the network or expanded it in new directions. This boot-strapping process would gradually lessen the dependence on the initial catalytic environment and allow the reaction network to persist using catalysts of its own making. Eventually, this process leads to the seemingly inseparable interdependence at the heart of biology between catalysts (coenzymes, enzymes, genes) and the metabolic pathways that synthesize them. Experimentally, the primary challenge is to recreate the conditions where such a network emerged. However, the near infinite number of microenvironments and sources of energy available on the early Earth or elsewhere poses an enormous combinatorial challenge. To constrain the search, our lab has been surveying conditions where the reactions making up the core of some of the most ancient chemolithoautotrophic metabolisms, which consist of only a small number of repeating chemical mechanisms, occur nonenzymatically. To give a fresh viewpoint in the first part of this account, we have organized the results of our search (along with important results from other laboratories) by reaction mechanism, rather than by pathway. We expect that identifying a common set of conditions for each type of reaction mechanism will help pinpoint the conditions for the emergence of a self-organized reaction network resembling core metabolism. Many of the reaction mechanisms were found to occur in a wide variety of nonenzymatic conditions. Others, such as carboxylate phosphorylation and C–C bond formation from CO2, were found to be the most constraining, and thus help narrow the scope of environments where a reaction network could emerge. In the second part of this account, we highlight examples where small molecules produced by metabolism, known as coenzymes, mediate nonenzymatic chemistry of the type needed for the coenzyme’s own synthesis or that turn on new reactivity of interest for expanding a hypothetical protometabolic network. These examples often feature cooperativity between small organic coenzymes and metal ions, recapitulating the transition from inorganic to organic catalysis during the origin of life. Overall, the most interesting conditions are those containing a reducing potential equivalent to H2gas (electrochemical or H2itself), Fe in both reduced and more oxidized forms (possibly with other metals like Ni) and localized strong electric fields. Environments that satisfy these criteria simultaneously will be of prime interest for reconstructing a metabolic origin of life.

An ointment containing larch turpentine, turpentine oil, and eucalyptus oil has been used for almost a century for the symptomatic treatment of mild, localized, purulent inflammations of the skin. Its clinical efficacy in the treatment of skin infections has been shown in clinical trials, but the mode of action of the active ingredients on inflammation is not known. We studied the anti-inflammatory properties of the active ingredients of the ointment and their mixture in a human monocyte cell model, in which the cells were stimulated with lipopolysaccharide and incubated with the test substances. The cytotoxic threshold of each test substance and the mixture was identified using the alamarBlue assay, and their anti-inflammatory activity was assessed by measuring the release of interleukins IL-1 β , IL-6, IL-8, monocyte chemoattractant protein-1, prostaglandin E2 , and TNF- α. Cell toxicity was observed at a mixture concentration of 10 µg/mL. All immunological assays were carried out at nontoxic concentrations. Larch turpentine decreased IL-1 β , monocyte chemoattractant protein-1, and prostaglandin E2 release at a concentration of 3.9 µg/mL and TNF- α at concentrations > 1.95 µg/mL, whereas eucalyptus oil and turpentine oil had no relevant inhibitory effects. The mixture dose-dependently inhibited IL-1 β , IL-6, monocyte chemoattractant protein-1, prostaglandin E2 , and TNF- α release at concentrations > 1 µg/mL. IL-8 release was only marginally affected. The anti-inflammatory activity of the herbal ingredients and their mixture was confirmed in this model. This effect seems to be mediated mainly by larch turpentine, with turpentine oil and eucalyptus oil exerting an additive or possibly synergistic function. [ABSTRACT FROM AUTHOR]

•Cerebral organoids mimic critical structures of the human CNS tissue and can be using to investigate CNS leukemia.•Using cerebral organoids concomitant to PDX mouse models, we identify the AP-1 pathway as a critical driver of CNS leukemia.

Abstract: Neonatology is a pediatric sub-discipline focused on providing care for newborn infants, including healthy newborns, those born prematurely, and those who present with illnesses or malformations requiring medical care. The European Training Requirements (ETR) in Neonatology provide a framework for standardized quality and recognition of equality of training throughout Europe. The latest ETR version was approved by the Union of European Medical Specialists (UEMS) in April 2021. Here, we present the curriculum of the European School of Neonatology Master of Advanced Studies (ESN MAS), which is based on the ETR in Neonatology and aims to provide a model for effective and standardized training and education in neonatal medicine. We review the history and theory that form the foundation of contemporary medical education and training, provide a literature review on best practices for medical training, pediatric training, and neonatology training specifically, including educational frameworks and evidence-based systems of evaluation. The ESN MAS Curriculum is then evaluated in light of these best practices to define its role in meeting the need for a standardized empirically supported neonatology training curriculum for physicians, and in the future for nurses, to improve the quality of neonatal care for all infants. Impact statement:

A review of the neonatology training literature was conducted, which concluded that there is a need for standardized neonatology training across international contexts to keep pace with growth in the field and rapidly advancing technology. This article presents the European School of Neonatology Master of Advanced Studies in Neonatology, which is intended to provide a standardized training curriculum for pediatricians and nurses seeking sub-specialization in neonatology. The curriculum is evaluated in light of best practices in medical education, neonatology training, and adult learning theory.

Colorectal surgery still experiences high rates of infectious complications, such as anastomotic leakage (AL) and surgical site infections (SSIs). Therefore, oral antibiotic bowel decontamination (OABD) has experienced a renaissance. However, data on perioperative selective digestive tract decontamination (SDD)–based regimens or combined bowel preparation are inconsistent. Nonetheless, with widespread use of Enhanced Recovery After Surgery concepts, the ideal length for perioperative SDD treatment has to be reconsidered.

This research investigates the relation between climate anxiety, threat perceptions for future generations, and childbearing motivations in childless emerging adults. Using a sample of 1211 Swiss college students aged 18–25, the study explores if threat perceptions mediate the relationship between climate anxiety and childbearing motivations. Results from structural equation modeling (SEM) indicated that climate anxiety significantly predicted greater perceptions of threat, which in turn related to less positive childbearing motivations and more negative childbearing motivations. Specifically, the relationship between climate anxiety and childbearing motivations was partly to fully explained by threat perceptions, suggesting that worries about the future environment could be an important factor in emerging adults’ complex reproductive considerations. No gender moderation was found. These findings underscore the need for policy interventions that provide psychological support and targeted educational resources to assist young adults in navigating the complex interplay between climate anxiety, threat perceptions, and their decisions regarding childbearing.

Reducing human-made greenhouse gas emissions is crucially important for life on earth, but it requires restructuring industries in ways that could disrupt millions of workers’ lives globally. Whether this transition is “just” from the perspective of workers depends on the magnitude of job losses, the quality of new jobs, and the transitions workers experience from their current jobs to new ones. Using the example of the German automotive industry, where the shift to electric vehicle production has recently accelerated, the authors identify recommendations for unions and policymakers in North America and beyond. This article provides an overview of the tools for workers and trade unions in Germany to steer the transition and shows how analogous tools could be strengthened or created elsewhere.

The analysis of histopathology images with artificial intelligence aims to enable clinical decision support systems and precision medicine. The success of such applications depends on the ability to model the diverse patterns observed in pathology images. To this end, we present Virchow, the largest foundation model for computational pathology to date. In addition to the evaluation of biomarker prediction and cell identification, we demonstrate that a large foundation model enables pan-cancer detection, achieving 0.95 specimen-level area under the (receiver operating characteristic) curve across nine common and seven rare cancers. Furthermore, we show that with less training data, the pan-cancer detector built on Virchow can achieve similar performance to tissue-specific clinical-grade models in production and outperform them on some rare variants of cancer. Virchow’s performance gains highlight the value of a foundation model and open possibilities for many high-impact applications with limited amounts of labeled training data.

Previous studies showed that pre- and probiotics may enhance iron absorption. Probiotics combined with prebiotics (synbiotics), including human-identical milk oligosaccharides (HiMOs), are commonly added to infant and follow-up formula (FUF). Whether these additions enhance iron absorption from iron-fortified commercial milk formula is uncertain.

Graphical abstract:

•This study reveals a novel recurrent genetic variant (TRB::NOTCH1) with significant prognostic relevance in T-LBL.•TRB::NOTCH1is absent in the analyzed T-ALL cohort.

In the industrial sector, products evolve significantly over their operational life. A key challenge has been maintaining precise, relevant engineering data. This paper explores the digital twin concept, merging engineering and operational data to enhance product information updates. It examines digital twin applications in construction, material flow, manufacturing and production, citing battery production and additive manufacturing. Digital twins aid in analyzing, experimenting with, and refining a system’s design and its operation, offering insights across product and system lifecycles. This includes tackling data management and model-data consistency challenges, as well as the recognition of synergies. This paper emphasizes sustainable, efficient management of engineering information, reflecting shifts in product longevity and documentation in industrial products and machinery.

Besides safety and security applications, ion mobility spectrometry (IMS) is increasingly used in other fields such as medicine, environmental monitoring and food quality analysis. However, some applications require gas chromatographic separation before analysis by IMS. Furthermore, different compounds in the sample may form positive or negative ions during ionization and therefore simultaneous detection of both ion polarities is highly beneficial to avoid two chromatographic runs of the same sample. This can be achieved by ultra-fast polarity switching of a single drift tube IMS, allowing for quasi-simultaneous detection of both ion polarities. By using a ramped aperture voltage during the switching process, we overcome the issue of excessive displacement currents at the detector during polarity switching, which usually lead to overdriving the output signal of the high-gain transimpedance amplifier. Furthermore, mechanical aperture grid oscillations caused by polarity switching were also reduced through the ramped aperture voltage. This enables a polarity switching time of only 7 ms at a drift voltage of 8 kV and a drift length of 103 mm, leading to a high resolving power of RP= 117. Requiring 50 ms to acquire a pair of positive and negative spectrum, the IMS achieves an acquisition rate of 20 Hz. It reaches limits of detection of 20 pptvfor dimethyl methylphosphonate and 40 pptvfor methyl salicylate. For demonstration, different hop varieties were investigated and could be clearly differentiated by considering both, the positive and negative spectra.

• Flash-annealing of Cu 47.5 Zr 47.5 Al 5 and Cu 46.5 Zr 48 Al 4 Nb 1.5 metallic-glass ribbons. • Cu 10 Zr 7 precipitates enhance mechanical performance of obtained composites materials. • Nanocrystalline materials have good corrosion resistance in NaCL and H 2 SO 4 solutions. Metallic-glass–crystal composites of Cu 47.5 Zr 47.5 Al 5 and Cu 10 Zr 7 -reinforced Cu 46.5 Zr 48 Al 4 Nb 1.5 nanocrystalline materials are obtained by flash-annealing of metallic-glass ribbons. In situ high-energy X-ray diffraction reveals the deformation mechanism of the alloys upon tensile loading. For the composites and nanocrystalline materials, a small remaining amount of the metallic glass and/or the presence of the Cu 10 Zr 7 phase significantly increase the value of yield stress while maintaining good tensile ductility. In general, the obtained materials exhibit a reversible martensitic transformation (MT) between the B2 CuZr and B19′/B33 phases during tensile loading and unloading. However, the reversibility of MT depends on the alloy composition, crystalline phases, and the number of (un)loading cycles. Serrated-like fluctuations on tensile stress-strain curves and a sign of twinning in the Cu 10 Zr 7 crystals are found after yielding in the Cu 10 Zr 7 -reinforced Cu 46.5 Zr 48 Al 4 Nb 1.5 nanocrystalline materials. Electrochemical measurements show that Cu 46.5 Zr 48 Al 4 Nb 1.5 nanocrystalline material has good corrosion resistance in NaCl and H 2 SO 4 solutions, even better than the parent metallic glasses in some aspects. [Display omitted] [ABSTRACT FROM AUTHOR]

Early Barrett cancer can be curatively treated by endoscopic resection. The choice of the resection technique, however—endoscopic mucosal resection (EMR) or submucosal dissection (ESD)—largely depends on the assumed infiltration depth as judged by the endoscopist. However, the accuracy of endoscopic diagnosis of the degree of cancer infiltration is not known. Three to four high‐quality images (both in overview and close‐up) from 202 of early Barrett esophagus cancer cases (82% men, mean age 66.9 years) were selected from our endoscopy database (73.3% stage T1a and 26.7% in stage T1b). Images were shown to 9 Barrett esophagus experts, with patients' clinical data (age, sex, Barrett esophagus length) and biopsy results. The experts were asked to predict infiltration depth (T1b vs. T1a), and to suggest the appropriate endoscopic resection technique (EMR or ESD, or surgery). Interobserver variability (kappa values) was also determined for these parameters. Overall positive (PPV) and negative predictive values (NPV) to diagnose T1b versus T1a infiltration were 40.7% (95% CI: 36.7, 44.8) and 79.8% (95% CI: 77.5, 81.9), respectively; kappa value was 0.41. Paris classification (kappa 0.51) and suggested treatment also varied between experts. In a post hoc analysis, only the correlation between lesions classified as invisible or flat according to the Paris classification (IIB; 25% of all cases) and the suggested resection technique was better: In this subgroup, EMR was recommended in >80% of cases, with a high complete (basal R0) resection rate (mean of 88.1%). Precise endoscopic distinction between mucosal and submucosal involvement of Barrett esophagus cancer by experts as a basis for choosing the resection technique has limited predictive values and high interobserver variability. It seems that mainly invisible/flat lesions may result in good resection outcomes when treated by EMR, but this stratification strategy has to be assessed in further studies.

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and reduced incidence of cardiovascular and neurodegenerative diseases across species borders. Here, we asked whether the cellular and physiological consequences of caloric restriction and fasting depend on polyamine metabolism. We report that spermidine levels increased upon distinct regimens of fasting or caloric restriction in yeast, flies, mice and human volunteers. Genetic or pharmacological blockade of endogenous spermidine synthesis reduced fasting-induced autophagy in yeast, nematodes and human cells. Furthermore, perturbing the polyamine pathway in vivo abrogated the lifespan- and healthspan-extending effects, as well as the cardioprotective and anti-arthritic consequences of fasting. Mechanistically, spermidine mediated these effects via autophagy induction and hypusination of the translation regulator eIF5A. In summary, the polyamine–hypusination axis emerges as a phylogenetically conserved metabolic control hub for fasting-mediated autophagy enhancement and longevity.

Dieser Beitrag in der Zeitschrift „Gruppe. Interaktion. Organisation. (GIO)“ führt in das Konzept der Ambiguitätstoleranz ein und verdeutlicht seine Relevanz im gegenwärtigen Zeitgeschehen. Ambiguitätstoleranz wird gemeinhin als wichtige Kompetenz auch im organisationalen Kontext gesehen, um Mehrdeutigkeiten und Unsicherheiten auszuhalten und in krisenhaften Zeiten handlungsfähig zu bleiben. Nachdem die Autor:innen des Beitrags detaillierter auf die Entstehung des aus den 1940ern stammenden Konzeptes eingegangen sind, verdeutlichen sie seine hohe gesellschaftspolitische Relevanz anhand des Diskurses um die documenta 15, des Streites um den Konflikt in Nahost und der Reaktionen auf die Enthüllungen von Correctiv zur Neuen Rechten. Daran anknüpfend zeigen sie auf, was sich daraus für den Organisationskontext ableiten lässt. Abschließend widmet sich der Beitrag der Frage der Erlernbarkeit von Ambiguitätstoleranz und zeigt dessen Voraussetzungen auf.

SwampScapes (2018) by Elizabeth Miller, Kim Grinfeder, and Juan Carlos Zaldivar. SWAMPS ARE EVERYWHERE Water, land, animals, trees, plants, flowers, insects, and humans are entangled with past and present racism [...]

The article evaluates GitHub's Copilot, an AI (Artificial Intelligence) pair programmer that simulates two programmers working together synchronously.

Los tumores malignos del tracto urinario están asociados a gran morbimortalidad siendo su prevalencia variable a nivel global. Recientemente el estudio IDENTIFY ha publicado resultados sobre la prevalencia del cáncer del tracto urinario a nivel internacional. Este estudio evalúa la prevalencia de cáncer dentro de la cohorte española del estudio IDENTIFY para determinar si los resultados publicados son extrapolables a nuestra población.

As the digital landscape evolves, states are increasingly implementing national cyber incident reporting obligations to enhance cyber resilience. This study investigates the implications of these obligations on multinational organizations, focusing on the variability of compliance requirements across jurisdictions and the challenges faced by companies in adhering to these diverse regulations. Through the methodological approach of conducting interviews with cybersecurity experts across various sectors, this study points out the growing complexity in cybersecurity incident reporting obligations. Findings reveal that companies employ multiple strategies to report to regulators, monitor regulatory changes, and educate employees responsible for reporting. However, maintaining compliance is identified as a significant challenge across all sectors, leading to calls for the standardization of regulations and the improvement of automation solutions. Given the lack of research in this area, this work lays the groundwork for future research, opening new avenues for investigation into the potential standardization and automation of cyber incident reporting processes.

Rare eosinophil-associated disorders (EADs), including hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, and eosinophilic gastrointestinal disorders, are a heterogeneous group of conditions characterized by blood and/or tissue hypereosinophilia and eosinophil-related clinical manifestations. Although the recent availability of biologic therapies that directly and indirectly target eosinophils has the potential to dramatically improve treatment options for all EADs, clinical trials addressing their safety and efficacy in rare EADs have been relatively few. Consequently, patient access to therapy is limited for many biologics, and the establishment of evidence-based treatment guidelines has been extremely difficult. In this regard, multicenter retrospective collaborative studies focusing on disease manifestations and treatment responses in rare EADs have provided invaluable data for physicians managing patients with these conditions and helped identify important questions for future translational research. During the Clinical Pre-Meeting Workshop held in association with the July 2023 biennial meeting of the International Eosinophil Society in Hamilton, Ontario, Canada, the successes and limitations of pivotal multicenter retrospective studies in EADs were summarized and unmet needs regarding the establishment of guidelines for use of biologics in rare EADs were discussed. Key topics of interest included (1) clinical outcome measures, (2) minimally invasive biomarkers of disease activity, (3) predictors of response to biologic agents, and (4) long-term safety of eosinophil depletion. Herein, we report a summary of these discussions, presenting a state-of-the-art overview of data currently available for each of these topics, the limitations of the data, and avenues for future data generation through implementation of multidisciplinary and multicenter studies.The 2023 International Eosinophil Society meeting featured a clinically focused workshop that discussed prior research and identified unmet needs in biologic treatment of eosinophil-associated diseases.

Eukaryotic cells contain several membrane-separated organelles to compartmentalize distinct metabolic reactions. However, it has remained unclear how these organelle systems are coordinated when cells adapt metabolic pathways to support their development, survival or effector functions. Here we present OrgaPlexing, a multi-spectral organelle imaging approach for the comprehensive mapping of six key metabolic organelles and their interactions. We use this analysis on macrophages, immune cells that undergo rapid metabolic switches upon sensing bacterial and inflammatory stimuli. Our results identify lipid droplets (LDs) as primary inflammatory responder organelle, which forms three- and four-way interactions with other organelles. While clusters with endoplasmic reticulum (ER) and mitochondria (mitochondria–ER–LD unit) help supply fatty acids for LD growth, the additional recruitment of peroxisomes (mitochondria–ER–peroxisome–LD unit) supports fatty acid efflux from LDs. Interference with individual components of these units has direct functional consequences for inflammatory lipid mediator synthesis. Together, we show that macrophages form functional multi-organellar units to support metabolic adaptation and provide an experimental strategy to identify organelle-metabolic signalling hubs.

Shortage in nursing resource results from the combination of a lack of nurses, an increased patient volume and workload, and other factors. This seems to be a worldwide phenomenon, leading to multiple health care related challenges and a decreased quality of care, but is different in extent in high- vs. low-income countries. An international perspective can alleviate challenges to keep our patients safe through increasing our health workers' safety.

In this article, we address the issue of modeling and estimating changes in the state of the spatio-temporal dynamical systems based on a sequence of observations like video frames. Traditional numerical simulation systems depend largely on the initial settings and correctness of the constructed partial differential equations (PDEs). Despite recent efforts yielding significant success in discovering data-driven PDEs with neural networks, the limitations posed by singular scenarios and the absence of local insights prevent them from performing effectively in a broader real-world context. To this end, this article propose the universal expert module – that is, optical flow estimation component, to capture the evolution laws of general physical processes in a data-driven fashion. To enhance local insight, we painstakingly design a finer-grained physical pipeline, since local characteristics may be influenced by various internal contextual information, which may contradict the macroscopic properties of the whole system. Further, we harness currently popular neural discrete learning to unveil the underlying important features in its latent space, this process better injects interpretability, which can help us obtain a powerful prior over these discrete random variables. We conduct extensive experiments and ablations to demonstrate that the proposed framework achieves large performance margins, compared with the existing SOTA baselines.

This article examines the wage earnings of refugee immigrants in Sweden. Using administrative employer–employee data from 1990 onward, approximately 100,000 refugee immigrants who arrived between 1980 and 1996 and were granted asylum are compared to a matched sample of native-born workers. Employing recentered influence function (RIF) quantile regressions to wage earnings for the period 2011–2015, the occupational-task-based Oaxaca–Blinder decomposition approach shows that refugees perform better than natives at the median wage, controlling for individual and firm characteristics. This overperformance is attributable to female refugee immigrants. Given their characteristics, refugee immigrant females perform better than native females across all occupational tasks studied, including non-routine cognitive tasks. A notable similarity of the wage premium exists among various refugee groups, suggesting that cultural differences and the length of time spent in the host country do not have a major impact.

Intensified systemic chemotherapy has the highest primary cure rate for advanced-stage, classical Hodgkin lymphoma but this comes with a cost of severe and potentially life long, persisting toxicities. With the new regimen of brentuximab vedotin, etoposide, cyclophosphamide, doxorubicin, dacarbazine, and dexamethasone (BrECADD), we aimed to improve the risk-to-benefit ratio of treatment of advanced-stage, classical Hodgkin lymphoma guided by PET after two cycles.

In February 2011 the Brunel Sound Series hosted Phill Niblock at Brunel University London, a memorable visit expertly orchestrated by our late colleague Bob Gilmore.1The occasion featured Phill's Disseminateand the premiere of his TWO LIPS aka Nameless, led by Bob. As an amateur clarinet player, in an ensemble made up of Brunel staff and students, I had the privilege of delving into the intricacies of Niblock's compositions. The event marked a significant chapter in our music department's history, with performances at Brunel University and, a day later, at London's trendiest club for hip contemporary music, Cafe OTO, in Dalston, leaving an indelible imprint on our students’ musical journey, and not just theirs.2

Cocconeis ectorii and C. azteca are described as new species based on unialgal strains, cultivated from samples collected in streams of Mexico, California, and Germany. For C. ectorii, strains from Mayotte Island and Spain were re-analysed. Although these two new species belong morphologically within the C. placentula group, genetic distances for the nuclear-encoded 18S-V4 and the plastid gene rbcL show that these species are distinct from other species with available sequencing data. Morphologically, these two taxa can be distinguished from similar species by a combination of characters such as length, width, striae and areolae count, size of hyaline rim, number of submarginal areolae, by closed or open valvocopulae of both valves and their additional features fimbriation and smoothness. These characters are difficult to assess in environmental samples containing several taxa from this group especially when only small specimens are identified with light microscopy. Despite the disjunct origin of the 13 analysed C. ectorii strains, encompassing different climatic zones, their diagnostic morphological features are broad but stable, and share identical sequences for the two markers, indicative of a cosmopolitan distribution. Lastly, we provide occurrence notes for freshwater species of the placentuloid group based on eDNA metabarcoding data from subpolar, temperate, and tropical zones, further supporting the global distribution of C. ectorii and the probable endemic occurrence of C. azteca in North America.

ABSTRACTDuponchelia fovealisis responsible for great losses in the strawberry production, and entomopathogenic fungi (EPF) are an alternative to control this larva. They can be used in combination with other natural compounds with insecticidal activity, such as plant extracts or essential oils (EOs). Thus, our objectives are to evaluate the effects of Baccharis dracunculifoliaand Baccharis uncinellaEOs on strawberry leaves and third instar larvae of D. fovealis, and to evaluate their in vitrocompatibility with strains of Beauveria bassianaand Cordyceps javanica. EOs were not phytotoxic to strawberry leaves at 2% v/v. Larval mortality ranged between 48% and 83% at 1% and 2%, and B. dracunculifoliaEO at 2% presented the higher mortality. EO of B. uncinella(BU) at 1% was compatible with two strains of B. bassianaand C. javanica. Therefore, the combined use of BU EO with EPF may be an alternative to control D. fovealis.