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Graphical abstract:

Graphical Abstract:

Phytochemical profiles of essential oil (EO), fatty acids, and n-hexane (CAH), diethyl ether (CAD), ethyl acetate (CAE) and methanol extracts (CAM) of Cota altissimaL. J. Gay (syn. Anthemis altissimaL.) were investigated as well as their antioxidant, anti-inflammatory, antidiabetic and antimicrobial activites. The essential oil was characterized by the content of acetophenone (35.8%) and β-caryophyllene (10.3%) by GC-MS/FID. Linoleic and oleic acid were found as main fatty acids. The major constituents of the extracts were found to be 5-caffeoylquinic acid, 3,5-dicaffeoylquinic acid, isorhamnetin glucoside, quercetin and quercetin glucoside by LC-MS/MS. Antioxidant activities of the extracts were determined by scavenging of DPPH and ABTS free radicals. Also, the inhibitory effects on lipoxygenase and α-glucosidase enzymes were determined. Antimicrobial activity was evaluated against Gram positive, Gram negative bacteria and yeast pathogens. CAMshowed the highest antioxidant activity against DPPH and ABTS radicals with IC50values of 126.60 and 144.40 μg/mL, respectively. In the anti-inflammatory activity, CAEdemonstrated the highest antilipoxygenase activity with an IC50value of 105.40 μg/mL, whereas, CAD showed the best inhibition of α-glucosidase with an IC50value of 396.40 μg/mL in the antidiabetic activity. CAHwas effective against Staphylococcus aureusat MIC = 312.5 µg/mL. This is the first report on antidiabetic, anti-inflammatory and antimicrobial activities of different extracts of C. altissima.

To investigate the potential radioprotective effects of Myrtus communison brain tissue.