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C4 Therapeutics Inc. has published a patent application for a compound called Compound 1, which selectively degrades the protein BRD9 involved in cancer proliferation. Compound 1 has shown promising results in cancer cells, particularly synovial sarcoma and SMARCB1 perturbed cancer. It can be taken orally and has high selectivity for BRD9 degradation, making it a potential treatment for BRD9-mediated disorders, including certain types of cancer. The patent application also discusses the synthesis of Compound 1 and the discovery of a stable morphic form (Form N) with improved properties. Various methods for using Compound 1 or its morphic forms, alone or in combination with other therapies, are described for the treatment of BRD9-mediated disorders. [Extracted from the article]

Standard-Knapp (S-K) based in Portland, Connecticut, has signed an agreement to partner with EoL Packaging Experts (EoL), an international market leader in end-of-line packaging solutions for the food and beverage [...]

In response to the climate emergency declared in many German cities in 2019, political decision makers, planners and researchers began promoting climate resilience in policy areas such as housing. This article discusses the potential impact and implementation of housing-market monitoring and housing action plans on analytical and strategic capacities at local and regional levels by presenting findings from a transdisciplinary, multi-level real-world laboratory in the Ruhr city region in Germany. It proposes an integrated multi-level approach to raise awareness and provide an accessible database for housing policies in climate-resilient city regions across administrative levels and sectoral borders. Keywords: housing for climate-resilient urban regions, housing action plan, housing-market monitoring, housing-policy instruments, real-world laboratory, multi-level perspective, Introduction: transforming the housing sector for climate resilience In 2019, municipalities in Germany and many other countries declared a state of climate emergency. Political decision makers and researchers began to [...]

Introduction Marijuana legalization emerges as a controversial issue globally (Caulkins et al, 2015; Stringer & Maggard, 2016). In Canada, legalizing the recreational and medical application of marijuana could generate a [...]

ABSTRACT In this paper, a method for the effective modeling of helically stranded cables for which multiple beam finite elements (FE) are used is presented, and a design procedure for [...]

ABSTRACT One of the major defects in concrete bridge decks are the formation of early age micro cracking which ultimately reduces its durability. The inclusion of fibers in concrete slabs [...]

Up Up, Down Down: Essays Cheston Knapp. Scribner, $25 (320p) ISBN 978-1-5011-6102-5 From the first page, Tin House editor Knapp's roundhouse, fullmouthed style takes a firmly tongue-in-cheek approach to the [...]

It is widely accepted that multiple exposures to an ad improve memory about a brand and that multiple executions avoid boredom and present different aspects of a brand. However, this [...]

FROM INGREDIENTS TO FINISHED PRODUCTS TO WAREHOUSE EQUIPMENT, NEW ideas and solutions serve as fuel to keep beverage-makers and distributors going. As industry events such as Pack Expo demonstrate, equipment [...]

Van de Ven and Poole (1995) point out that existing models and theories of organizational change have not significantly advanced our understanding of the processes and sequences of events that [...]