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Inverse molecular design allows the optimization of molecules in chemical space and is promising for accelerating the development of functional molecules and materials. To design realistic molecules, it is necessary to consider geometric stability during optimization. In this work, we introduce an inverse design method that optimizes molecular properties by changing the chemical composition in the equilibrium geometry. The optimization algorithm of our recently developed molecular design method has been modified to allow molecular design for general properties at a low computational cost. The proposed method is based on quantum alchemy and does not require empirical data. We demonstrate the applicability and limitations of the present method in the optimization of the electric dipole moment and atomization energy in small chemical spaces for (BF, CO), (N2, CO), BN-doped benzene derivatives, and BN-doped butane derivatives. It was found that the optimality criteria scheme adopted for updating the molecular species yields faster convergence of the optimization and requires a less computational cost. Moreover, we also investigate and discuss the applicability of quantum alchemy to the electric dipole moment.

To elucidate the reaction mechanism and the origin of the enantioselectivity of the asymmetric dehydrative cyclization of allyl alcohol to cyclic ether catalyzed by a Cp-ruthenium complex and a chiral pyridinecarboxylic acid, (R)-X-Naph-PyCOOH, density functional theory (DFT) calculations were performed. According to the DFT calculations, the rate-determining step is the dehydrative σ-allyl formation step with ΔG‡= 18.1 kcal mol–1at 80 °C. This agrees well with the experimental data (ΔG‡= 19.01 kcal mol–1at 80 °C). The DFT result showed that both hydrogen and halogen bonds play a key role in the high enantioselectivity by facilitating the major R,SRu-catalyzed reaction pathway via a σ-allyl Ru intermediate to generate the major (S)-product. In contrast, the reaction is sluggish in the presence of the diastereomeric R,RRucatalyst with an apparent activation energy of 33.1 kcal mol–1; the minor (R)-product is formed via a typical π-allyl Ru intermediate and via a minor pathway for the cyclization step. In addition, the calculated activation Gibbs free energies, 14.4 kcal mol–1for I < 16.8 kcal mol–1for Br < 18.1 kcal mol–1for Cl, reproduced the observed halogen-dependent reactivity with the (R)-X-Naph-PyCOOH ligands. The origin of the halogen trend was clarified by a structural decomposition analysis.

We focused on identifying a catalytic active site structure at the atomic level and elucidating the mechanism at the elementary reaction level of liquid-phase organic reactions with a heterogeneous catalyst. In this study, we experimentally and computationally investigated efficient C–H bond activation for the selective aerobic α,β-dehydrogenation of saturated ketones by using a Pd–Au bimetallic nanoparticle catalyst supported on CeO2(Pd/Au/CeO2) as a case study. Detailed characterization of the catalyst with various observation methods revealed that bimetallic nanoparticles formed on the CeO2support with an average size of about 2.5 nm and comprised a Au nanoparticle core and PdO nanospecies dispersed on the core. The formation mechanism of the nanoparticles was clarified through using several CeO2-supported controlled catalysts. Activity tests and detailed characterizations demonstrated that the dehydrogenation activity increased with the coordination numbers of Pd–O species in the presence of Au(0) species. Such experimental evidence suggests that a Pd(II)–(μ-O)–Au(0) structure is the true active site for this reaction. Based on density functional theory calculations using a suitable Pd1O2Au12cluster model with the Pd(II)–(μ-O)–Au(0) structure, we propose a C–H bond activation mechanism via concerted catalysis in which the Pd atom acts as a Lewis acid and the adjacent μ-oxo species acts as a Brønsted base simultaneously. The calculated results reproduced the experimental results for the selective formation of 2-cyclohexen-1-one from cyclohexanone without forming phenol, the regioselectivity of the reaction, the turnover-limiting step, and the activation energy.

A compact inertial electrostatic confinement (IEC) fusion neutron source was developed. Imaging tests using the cylindrical IEC neutron source were conducted with the indirect imaging plate (IP) method using dysprosium foil and an imaging plate. An array of B_4C powder contained in a stainless-steel blade and Cd pins was successfully imaged. To calculate thermal neutron flux of the device, we tested multiple types of IP and IP scanners with the indirect IP method to create a calibration curve, and it was confirmed that dental IP scanners, which are more widely used than industrial ones, can be applied to the indirect IP method.

Recently, mechanical ball milling was applied to chitin depolymerization. The mechanical activation afforded higher selectivity toward glycosidic bond cleavage over amide bond breakage. Hence, the bioactive N-acetylglucosamine (GlcNAc) monomer was preferentially produced over glucosamine. In this regard, the force-dependent mechanochemical activation–deactivation process in the relaxed and pulled GlcNAc dimer undergoing deacetylation and depolymerization reactions was studied. For the relaxed case, the activation energies of the rate-determining steps (RDS) proved that the two reactions could occur simultaneously. Mechanical forces associated with ball milling were approximated with linear pulling and were introduced explicitly in the RDS of both reactions through force-modified potential energy surface (FMPES) formalism. In general, as the applied pulling force increases, the activation energy of the RDS of deacetylation shows no meaningful change, while that of depolymerization decreases. This result is consistent with the selectivity exhibited in the experiment. Energy and structural analyses for the depolymerization showed that the activation can be attributed to a significant change in the glycosidic dihedral at the reactant state. A lone pair of the neighboring pyranose ring O adopts a syn-periplanar conformation relative to the glycosidic bond. This promotes electron donation to the σ*-orbital of the glycosidic bond, leading to activation. Consequently, the Brønsted–Lowry basicity of the glycosidic oxygen also increases, which can facilitate acid catalysis.

The mechanism of the aza-aldol reaction between boron aza-enolate and benzaldehyde is investigated by using density functional theory calculations. The result shows that the syn-Eisomer is preferentially formed, consistent with experimental observations. The six-membered ring transition state (TS) with the boat form leads to the Eisomer, while the more unstable chair TS does to the Zisomer. The preference of the synisomer is determined by the interactions between the substituents of aza-enolate and benzaldehyde. Structural distortion and intrinsic reaction coordinate analyses of simplified model systems provide insights into the origin of the relative stability of the rate-determining TS with boat and chair forms. The boat TS is an early TS; thus, minimal structural distortions of the reactant are required to reach this TS. The Lewis pair interactions between the boron and imine groups during B–N elimination also influenced the relative stability of the TSs. This interaction involves the nitrogen lone pair in the boat TS, while the π(N═C) orbital is involved in the chair TS. The Lewis pair with the lone pair stabilizes the TS more than that with the π orbital. The boron aza-enolate with 9-BBN generates an ate complex and forms C–C bonds sequentially, whereas that with Bpin does not generate an ate complex and exhibits the concerted formation of B–O and C–C bonds. Thus, the higher electrophilicity of boron such as 9-BBN enhances the reactivity by facilitating the formation of the ate complex. A reaction design is proposed to reverse the syn/antiselectivity. Proof-of-concept DFT calculations suggested that the modification of the imine group would change the relative stability of the boat/chair TSs and give the anti-product.

During the hydrogenation of CO2to methanol over mixed-oxide catalysts, the strong adsorption of CO2and formate poses a barrier for H2dissociation, limiting methanol selectivity and productivity. Here we show that by using Co-containing dual-atom oxide catalysts, the poisoning effect can be countered by separating the site for H2dissociation and the adsorption of intermediates. We synthesized a Co- and In-doped ZrO2catalyst (Co–In–ZrO2) containing atomically dispersed Co and In species. Catalyst characterization showed that Co and In atoms were atomically dispersed and were in proximity to each other owing to a random distribution. During the CO2hydrogenation reaction, the Co atom was responsible for the adsorption of CO2and formate species, while the nearby In atoms promoted the hydrogenation of adsorbed intermediates. The cooperative effect increased the methanol selectivity to 86% over the dual-atom catalyst, and methanol productivity increased 2-fold in comparison to single-atom catalysts. This cooperative effect was extended to Co–Zn and Co–Ga doped ZrO2catalysts. This work presents a different approach to designing mixed-oxide catalysts for CO2hydrogenation based on the preferential adsorption of substrates and intermediates instead of promoting H2dissociation to mitigate the poisonous effects of substrates and intermediates.

In this work, we tested a setup of X-ray fluorescence (XRF) excited by proton-induced quasi-monochromatic X-rays (proton-induced XRF (PIXRF)) as a low-radiation dose analytical technique for precious cultural heritage samples. The low-dose performance of the PIXRF is experimentally assessed in comparison with the performance of a conventional XRF. For this assessment, we prepared test samples, which simulated original Japanese paintings with copper-bearing pigments. By introducing a figure-of-merit, the PIXRF is found to potentially give a better performance in terms of the radiation dose to the sample and the limit of detection, albeit the degraded multi-elemental analytical capability. PIXRF can be a cost-effective method to perform low dose measurements of precious samples, if introduced in an existing PIXE facility.

The mechanism of C–H activation of methane by liquid indium, which is the first step of the dehydrogenative conversion of methane to higher hydrocarbons, was investigated using density functional theory calculations. In the first-principle molecular dynamics trajectory at the experimental temperature (1200 K), low-coordinated indium atoms continuously appear on the disordered liquid surface. The C–H cleavage is endothermic on clean surfaces, while the low-coordinated indium atoms reduce the endothermicity significantly. In small indium clusters, which are models of low-coordinated atoms on a surface, the calculated activation energy is much smaller than that on the clean surface. The energy level of the methane C–H σ* orbital is reduced by the interaction with the indium 5pσ orbitals. In2shows the lowest activation energy and exothermicity in the C–H bond cleavage.

Reaction mechanisms of hydrosilylation of ketone and alkene with tertiary silane using the Wilkinson-type catalyst were theoretically investigated on the basis of density functional calculations using ωB97XD functional. Previously proposed three mechanisms, the Chalk–Harrod (CH) mechanism, the modified Chalk–Harrod (mCH) mechanism, and the outer-sphere mechanism were examined. Besides, we also found two mechanisms, the alternative CH (aCH) mechanism and the double hydride (DH) mechanism. In the aCH mechanism, a four-coordinate rhodium hydride complex formed through the elimination of R3Si–Cl is a catalytically active species. In the DH mechanism, the active species is a six-coordinate complex with two Rh–H bonds. For the C═O double bond hydrosilylation, the rate-determining steps of the aCH and DH mechanisms are both acetone insertion into the Rh–H bond, and the order of the activation barrier is DH < aCH ≈ CH < mCH. For the C═C double bond hydrosilylation, except for the mCH pathway whose rate-determining step is the hydrosilane addition reaction, the rate-determining steps of the CH, aCH, and DH pathways are Si–C reductive elimination reactions. The order of the energy barrier is DH ≈ mCH < aCH ≈ CH. In the outer-sphere mechanism, no stable intermediate or transition state was found. Consequently, we concluded that the DH mechanism is adopted as the mechanism for the Rh-catalyzed hydrosilylation of the carbonyl group while the mCH or DH mechanism is adopted as the mechanism for alkenes under conditions where their active intermediates are formed. The present result revises a hypothesis that the hydrosilylation of the carbonyl group is in general accomplished by the mCH mechanism. The active species in the DH mechanism has one more extra Rh–H bond compared to that of the other pathways, and its interaction with a silyl group, trans-influence, and small steric effect are the origin of the highly efficient catalytic activity, which was not reported before.

Single molecule magnets (SMMs) have been a promising material for next-generation high-density information storage and molecular spintronics. N23–-bridged dilanthanide complexes, {[(Me3Si)2N]2Ln(THF)(μ–η2:η2-N2)(THF)Ln[(Me3Si)2N]2}1–, exhibit high blocking temperatures and have been one of the promising candidates for future application. Rational understanding should be established between the magnetic properties and electronic structure. However, the theoretical study is still challenging due to the complexities in their electronic structures. Here, we theoretically studied the magnetic susceptibility of dilanthanide SMMs based on the state-of-the-art multistate-complete active space self-consistent field and perturbation theory at the second order and restricted active space state interaction with spin–orbit coupling calculations. Temperature dependence of the magnetic susceptibility (χmT–Tcurve) was quantitatively reproduced by the theoretical calculations. The complexities in the electronic states of these dilanthanide complexes originate from significantly strong static electron correlations in the lanthanide 4f and N2π* orbitals and the SOC effect. The temperature dependence of the magnetic susceptibility results from the energy levels and magnetic properties of the low-lying excited state. The χmTvalues below 50 K are dominated by the ground state, while thermal distribution in the low-lying excited state affects the χmTvalues over 50 K. Saturation magnetization at low temperatures was also evaluated, and the result agrees with the experimental observation.

Nine triterpene acids, viz., six of the ursane type, ursolic acid (1), corosolic acid (2), 3-epicorosolic acid (3), pomolic acid (4), tormentic acid (5) and hyptadienic acid (6), and three of the oleanane type, oleanolic acid (7), augustic acid (8) and 3-epimaslinic acid (9), among which 1constituted the most predominant triterpene acid, were isolated and identified from ethanol extracts of the leaves of red perilla [Perilla frutescens(L.) Britton var. acutaKudo] and green perilla [P. frutescens(L.) Britton var. acutaKudo forma viridisMakino]. These eight compounds, 1, 2, 4–9, were evaluated for their inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice. All the compounds tested showed a marked anti-inflammatory effect, with a 50% inhibitory dose (ID50) of 0.09–0.3 mg per ear. In addition, an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA showed five compounds, 1–3, 5and 9, with a potent inhibitory effect on EBV-EA induction (91–93% inhibition at 1×103mol ratio/TPA). Furthermore, compound 5exhibited strong antitumor-promoting activity in an in vivotwo-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter.

Rheumatoid arthritis (RA) is characterized by chronic inflammation of multiple joints. Large numbers of T cells, which produce type 1 cytokines, infiltrate into RA synovium. Chemokines and chemokine receptors are considered to contribute to the T cell infiltration. In this study, we examined the role of CX3CL1/fractalkine and its receptor CX3C chemokine receptor 1 (CX3CR1) in the T cell migration into RA synovium. Using flow cytometry, immunohistochemistry, and reverse transcription–polymerase chain reaction, we analyzed CX3CR1 expression by peripheral blood and synovial T cells, and CX3CL1 expression in synovium from patients with RA. Cytokine and cytotoxic molecule expression by CX3CR1-positive T cells was analyzed by flow cytometry. CX3CR1 expression by peripheral CD4+ and CD8+ T cells was up-regulated in RA patients. The peripheral CD4+ and CD8+ T cells expressing CX3CR1 predominantly produced interferon-γ and tumor necrosis factor α, and expressed cytotoxic molecules such as granzyme A and perforin. Furthermore, CX3CR1+,CD3+ T cells infiltrated into RA synovium. CX3CL1, the unique ligand of CX3CR1, was expressed by endothelial cells and synoviocytes in RA synovium, but not in osteoarthritis synovium. Our findings suggest that the interactions of CX3CL1 and CX3CR1 might contribute to the accumulation of CX3CR1+ T cells expressing type 1 cytokines and possessing cytotoxic granules in RA synovium.

In many vertebrate CNS synapses, the neurotransmitter glutamate activates postsynaptic non-N-methyl-d-aspartate (NMDA) and NMDA receptors. Since their biophysical properties are quite different, the time course of excitatory postsynaptic currents (EPSCs) depends largely on the relative contribution of their activation. To investigate whether the activation of the two receptor subtypes is affected by the synaptic interaction in the inner plexiform layer (IPL) of the mouse retina, we analyzed the properties of the light-evoked responses ofon-cone bipolar cells and on-transient amacrine cells in a retinal slice preparation. on-transient amacrine cells were whole cell voltage-clamped, and the glutamatergic synaptic input from bipolar cells was isolated by a cocktail of pharmacological agents (bicuculline, strychnine, curare, and atropine). Direct puff application of NMDA revealed the presence of functional NMDA receptors. However, the light-evoked EPSC was not significantly affected byd(−)-2-amino-5-phosphonopentanoic acid (d-AP5), but suppressed by 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX) or 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466). These results indicate that the light-evoked EPSC is mediated mainly by AMPA receptors under this condition. Since bipolar cells have GABACreceptors at their terminals, it has been suggested that bipolar cells receive feedback inhibition from amacrine cells. Application of (1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA), a specific blocker of GABACreceptors, suppressed both the GABA-induced current and the light-evoked feedback inhibition observed in on-cone bipolar cells and enhanced the light-evoked EPSC of on-transient amacrine cells. In the presence of TPMPA, the light-evoked EPSC of amacrine cells was composed of AMPA and NMDA receptor-mediated components. Our results suggest that photoresponses of on-transient amacrine cells in the mouse retina are modified by the activation of presynaptic GABACreceptors, which may control the extent of glutamate spillover.

13C Nuclear magnetic resonance (NMR) spectra of [3-13C]Ala-labeled bacteriorhodopsin (bR) were edited to give rise to regio-selective signals from hydrophobic transmembrane α-helices by using NMR relaxation reagent, Mn2+ ion. As a result of selective suppression of 13C NMR signals from the surfaces in the presence of Mn2+ ions, several 13C NMR signals of Ala residues in the transmembrane α-helices were identified on the basis of site-directed mutagenesis without overlaps from 13C NMR signals of residues located near the bilayer surfaces. The upper bound of the interatomic distances between 13C nucleus in bR and Mn2+ ions bound to the hydrophilic surface to cause suppressed peaks by the presence of Mn2+ ion was estimated as 8.7Å to result in the signal broadening to 100Hz and consistent with the data based on experimental finding. The Ala Cβ13C NMR peaks corresponding to Ala-51, Ala-53, Ala-81, Ala-84, and Ala-215 located around the extracellular half of the proton channel and Ala-184 located at the kink in the helix F were successfully identified on the basis of 13C NMR spectra of bR in the presence of Mn2+ ion and site-directed replacement of Ala by Gly or Val. Utilizing these peaks as probes to observe local structure in the transmembrane α-helices, dynamic conformation of the extracellular half of bR at ambient temperature was examined, and the local structures of Ala-215 and 184 were compared with those elucidated at low temperature. Conformational changes in the transmembrane α-helices induced in D85N and E204Q and its long-range transmission from the proton release site to the site around the Schiff base in E204Q were also examined.

Mesophilic cytochromec551of Pseudomonas aeruginosa(PAc551) became as stable as its thermophilic counterpart, Hydrogenobacter thermophiluscytochromec552(HT c552), through only five amino acid substitutions. The five residues, distributed in three spatially separated regions, were selected and mutated with reference to the corresponding residues in HTc552through careful structure comparison. Thermodynamic analysis indicated that the stability of the quintuple mutant of PA c551could be partly attained through an enthalpic factor. The solution structure of the mutant showed that, as in HT c552, there were tighter side chain packings in the mutated regions. Furthermore, the mutant had an increased total accessible surface area, resulting in great negative hydration free energy. Our results provide a novel example of protein stabilization in that limited amino acid substitutions can confer the overall stability of a natural highly thermophilic protein upon a mesophilic molecule.

Transcription of the liver type pyruvate kinase and lipogenesis enzyme genes is induced by high carbohydrate in liver. We have found a novel protein factor in rat liver nuclei that binds to the glucose response element (CACGTG motifs) of the pyruvate kinase gene (Liu, Z., Thompson, K. S., and Towle, H. C. (1993)J. Biol. Chem.268,12787–12795) and the “insulin response element” of fatty acid synthase gene. The amounts of this DNA-binding protein, termed “glucose response element binding protein” (GRBP) in the nuclear extract, were increased in liver by a high carbohydrate diet and decreased by starvation, high fat, and high protein diet. GRBP also occurs in cytosols of liver and is dependent on carbohydrate. Both the nuclear and the cytosolic GRBP showed similar properties, except the former was more resistant to thermal inactivation than the latter. Kinetics of glucose activation of the cytosolic GRBP in a primary culture of hepatocytes indicated that a half-maximum activation was achieved after 6 h, and glucose concentration required for the maximum activation of the GRBP was approximately 12 mm. Dibutyryl-cAMP, okadaic acid, and forskolin inhibited glucose activation of both GRBP and liver pyruvate kinase transcription. These results suggested that GRBP may be a factor that recognizes the glucose response motif site and may be involved in mediating carbohydrate response of the pyruvate kinase gene.

In endoscopic diagnosis, there has been a strong requirement to measure the internal surface topography of the rectum or esophagus. Accurate measurement, however, is very difficult, because the object is usually observed from an inclined view. In this paper, we propose a method to overcome this difficulty utilizing sequential stereo-pair images; the relative shape is roughly measured from sequential images taken by one of the change coupled device (CCD) cameras, and the size is determined by stereo-pair matching using the measured shape. A coarse-to-fine approach is also used to improve the resolution of topographic measurement. Through a basic experiment using a monocular CCD endoscope and a polyp phantom, the proposed method is confirmed to improve measurement accuracy in comparison with conventional methods.

We propose a new method to measure surface topography using a monocular endoscope. The surface structure is obtained up to a scale factor from an image sequence taken through a conventional CCD endoscope. The scale factor is determined by a photometric method, and the actual size of the object can be determined. The principle and experimental results are presented.

The object’s surface structure can be obtained from an image sequence taken through a conventional CCD endoscope. This paper reports clinical experimental results of the method. The accuracy of the estimation is studied and a method to estimate the reliability of the reconstructed shape is also described.

The interest in mechanochemical research has dramatically increased in recent years with the advent of computational chemistry tools where detailed reaction thermodynamics, and kinetics can be studied. However, most chemistry software packages do not include a functionality to address mechanochemical phenomena and computational chemists need to modify a quantum chemical software to perform specialized simulations. Current implementation includes Force Modified Potential Energy Surface (FMPES), External Force Explicitly Included (EFEI), and Enforce Geometry Optimizations (EGO) Formalism. This also includes a wall potential based function to simulate mechanical grinding. In this work, a python module that allows inclusion of external forces during molecular geometry optimizations and molecular dynamics simulations is presented while virtually employing any quantum chemical or molecular mechanical software. It is to be expected that OpenMechanochemwill facilitate mechanochemical reaction simulations that will explain the interplay of external forces to a chemical system.

A noninvasive detection system for cerebrovascular disease such as aneurysms, stenosis, and occlusions has been developed by using a specially designed PVDF‐film sensor and signal analysis based on FFT and the Wigner distribution. About 90 patients with cerebrovascular diseases and 30 normal persons were measured at the Department of Neurosurgery, Ube Industries Central Hospital. FFT spectral differences between patients and normal persons exist over the frequency range from 0.5 to 1.2 kHz. In particular, the differences in spectral components between 750 Hz and 1.5 kHz could be the possible index for diagnosis of the existence of cerebrovascular disease. The FFT spectral pattern showed some differences between stenosis and aneurysms. In stenosis, it seemed that there existed a flat level from 0.4 to 2.2 kHz, while in aneurysms the power decreases smoothly from the peak around 0.7 kHz. Time variance of the blood flow noise according to the cardiac cycle could be seen in the stenosis from 30% to 50%, but not in the cases from 40% to 90%.

For the post‐operative treatment of the prosthetic cardiac valve, its closure click was measured clinically. Ultrasonic range signal components, as well as the widely known audible signal components were found to exist. The frequency range of the ultrasonic click was from 8 kHz to more than 600 kHz, while that of the audible click was up to 8 kHz. Both of the clicks included effective diagnostic information. The Wigner distribution (WD) of the audible closing click offered the possible indices of thrombus and/or sclerosis. Especially, the first‐order local moment of the WD showed capability for the quantitative diagnosis of the thrombosed valve. The ultrasonic closing click offered more diagnostic information for the bileaflet valve, while it also had sensitivity for the thrombosed valve. Since the waveform of the ultrasonic click indicated clearly the instance of the valve closing, it also revealed the exact time difference between the closing time of each leaflet, which could be used as the indices of bileaflet valve malfunction. With those characteristics of the closing click, detailed diagnosis of the prosthetic cardiac valve malfunction could be determined.

Keywords: Kanagawa; Japan; Asia; Brain Cancer; Brain Diseases and Conditions; Brain Metastasis; Cancer; Clinical Research; Clinical Trials and Studies; Gynecology; Health and Medicine; Oncology; Ovarian Cancer; Women's Health EN Kanagawa Japan Asia Brain Cancer Brain Diseases and Conditions Brain Metastasis Cancer Clinical Research Clinical Trials and Studies Gynecology Health and Medicine Oncology Ovarian Cancer Women's Health 302 302 1 03/23/23 20230324 NES 230324 2023 MAR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Brain Diseases and Conditions - Brain Metastasis is the subject of a report. According to the news reporters, the research concluded: "GKRS for ovarian cancer brain metastasis can provide satisfactory survival and local control, especially in cases of serous adenocarcinoma.". [Extracted from the article]

2023 MAR 23 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Brain Diseases and Conditions - Brain Metastasis is the subject of [...]