Search

Developing efficient water splitting electrocatalysts plays a critical role in lowering the energy cost for hydrogen production, which requires accurate evaluation of the catalytic performance especially under industrially relevant conditions. In this work, we design a two-chamber electrolyzer testing system simulating practical water electrolyzer system to enable catalytic performance evaluation under industrially relevant conditions. A one-step electrodeposition method is used to synthesize binary and ternary Ni alloy HER catalysts and the catalytic electrodes are screened and optimized with the two-chamber electrolyzer testing system. A voltage of 1.64 V without iR compensation at a current density of 200 mA/cm2 is obtained with continuous operation for 70 h. Different HER activity trend is observed from conventional three-electrode experiments with low-concentration alkaline electrolytes at room temperature and the two-chamber electrolyzer measurements, further supporting the importance of catalytic performance evaluation under industrially relevant conditions. The electrodeposition synthesis method is further used to prepare large-area catalytic electrodes over 400 cm2 with good uniformity. • Ni-alloy HER catalysts are characterized under industrially relevant conditions with a home-build electrolyzer system. • Electrolyzer with an electrodeposited NiMo HER catalyst exhibits a remarkably low voltage of 1.64 V at 200 mA/cm2. • Different activity trends of HER catalysts are observed under industrially relevant conditions and three-electrode tests. • Ni-alloy catalysts with an active area over 400 cm2 are successfully synthesized with excellent performance uniformity. [ABSTRACT FROM AUTHOR]

Self‐charging power systems (SCPSs) are envisioned as promising solutions for emerging electronics to mitigate the increasing global concern about battery waste. However, present SCPSs suffer from large form factors, unscalable fabrication, and material complexity. Herein, a type of highly stable, eco‐friendly conductive inks based on poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) are developed for direct ink writing of multiple components in the SCPSs, including electrodes for miniaturized spacer‐free triboelectric nanogenerators (TENGs) and microsupercapacitors (MSCs), and interconnects. The principle of "one ink, multiple functions" enables to almost fully print the entire SCPSs on the same paper substrate in a monolithic manner without post‐integration. The monolithic fabrication significantly improves the upscaling capability for manufacturing and reduces the form factor of the entire SCPSs (a small footprint area of ≈2 cm × 3 cm and thickness of ≈1 mm). After pressing/releasing the TENGs for ≈79000 cycles, the 3‐cell series‐connected MSC array can be charged to 1.6 V while the 6‐cell array to 3.0 V. On‐paper SCPSs are promising to serve as lightweight, thin, sustainable, and low‐cost power supplies. [ABSTRACT FROM AUTHOR]

Harvesting renewable mechanical energy is envisioned as a promising and sustainable way for power generation. Many recent mechanical energy harvesters are able to produce instantaneous (pulsed) electricity with a high peak voltage of over 100 V. However, directly storing such irregular high‐voltage pulse electricity remains a great challenge. The use of extra power management components can boost storage efficiency but increase system complexity. Here utilizing the conducting polymer PEDOT:PSS, high‐rate metal‐free micro‐supercapacitor (MSC) arrays are successfully fabricated for direct high‐efficiency storage of high‐voltage pulse electricity. Within an area of 2.4 × 3.4 cm2 on various paper substrates, large‐scale MSC arrays (comprising up to 100 cells) can be printed to deliver a working voltage window of 160 V at an ultrahigh scan rate up to 30 V s−1. The ultrahigh rate capability enables the MSC arrays to quickly capture and efficiently store the high‐voltage (≈150 V) pulse electricity produced by a droplet‐based electricity generator at a high efficiency of 62%, significantly higher than that (<2%) of the batteries or capacitors demonstrated in the literature. Moreover, the compact and metal‐free features make these MSC arrays excellent candidates for sustainable high‐performance energy storage in self‐charging power systems. [ABSTRACT FROM AUTHOR]

A supramolecular solvent (SUPRAS)-based sample preparation method was proposed for the determination of lignans in Schisandra chinensis (S. chinensis) fruit. The optimal conditions were: proportion of hexafluoroisopropanol in SUPRAS: 35% (v/v), solid-to-liquid ratio: 20:1 mg/mL, and vortex time: 30 s. Additionally, simple, rapid, and sensitive high-performance liquid chromatography coupled with triple quadrupole mass spectrometry and multiple reaction monitoring was employed to simultaneously quantify seven lignans in S. chinensis. The validation showed that the linearity from 0.01 to 20.83 µg/mL was excellent (all R2 ≥ 0.99). The lowest limits of quantification were from 0.14 to 17.79 ng/mL. The relative standard deviation (RSD) of the intra-day retention time and peak area were from 0.12% to 0.21% and 2.35% to 6.41%. The RSD of retention time and peak area for the inter-day precision ranged from 0.17% to 0.32% and 3.83% to 7.39%. The average recoveries (80.21%–114.53%) demonstrated good accuracy for all analytes. The developed procedure was employed to determine lignans in processed and raw S. chinensis fruit. The lignans were concentrated in the seeds and the wine-processed material had the highest content. This study provides a reference for the analysis of S. chinensis fruit for lignans. [ABSTRACT FROM AUTHOR]

Green extraction of the active lignans from Schisandra chinensis has received considerable attention due to their promising applications in the biomedical field. In this study, microwave‐assisted deep eutectic solvent method was used to simultaneously extract five lignans: Schizandrol A, Schizandrol B, Schisantherin A, Schisandrin A and Schizandrin B. The extraction parameters were optimized according to the calculated comprehensive score obtained from the analytic hierarchy process combined with the entropy weight method. The optimal extraction conditions were that the molar ratio of choline chloride and glycolic acid is 4:1, water content is 30% (V/V), solid–liquid ratio is 1:20 (Wg:VmL), extraction time is 20 min, and extraction temperature is 70°C, under which the extraction rate of the five lignans were 10.89, 8.616, 4.019, 4.893, and 5.318 mg/g. These results confirmed that our extraction method is efficient and feasible for green extraction of lignans from S. chinensis. [ABSTRACT FROM AUTHOR]

Green synthesis of Ag nanoparticles (AgNPs) by using the plant extract is a very important strategy to gain efficient antimicrobial agents with strong antimicrobial activity and low toxicity. In this study, jujube seed extract (JSE) is utilized to green synthesis of AgNPs by both hydrothermal process and solution‐based approaches. UV–vis absorption spectroscopy and infrared spectroscopy (FTIR) spectra confirm that jujube seed extract functionalized Ag nanoparticles are formed by both approaches and jujube seed extract covered on the surface of Ag nanoparticles. Transmission electron microscopy (TEM) images indicate that the JSE‐AgNPs are spherical with the average diameter of 17.7 and 14.2 nm for the hydrothermal process and solution‐based approaches, respectively. X‐ray diffraction (XRD) results indicate that the JSE‐AgNPs prepared by both approaches have face‐centered cubic crystal structure. The antimicrobial activity test reveals that minimum inhibitory concentrations (MIC) of JSE‐AgNPs by the solution‐based method are 62.5, 125, and 62.5 µg mL−1 against Escherichia coli, Staphylococcus aureus, and Candida albicans, respectively. These results imply that the JSE‐AgNPs have potential to be developed as efficient antimicrobial agents. [ABSTRACT FROM AUTHOR]

Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression by increasing the formation of microRNA‐induced silencing complex (miRISC). High levels of pS417‐AGO2 in clinical NSCLC specimens are positively associated with poor prognosis. Interestingly, the treatment with EGFR inhibitor Gefitinib can significantly induce pS417‐AGO2, thereby increasing the formation and activity of oncogenic miRISC, which may contribute to NSCLC resistance to Gefitinib. Based on these, two therapeutic strategies is developed. One is jointly to antagonize multiple oncogenic miRNAs highly expressed in NSCLC and use TBK1 inhibitor Amlexanox reducing the formation of oncogenic miRISC. Another approach is to combine Gefitinib with Amlexanox to inhibit the progression of Gefitinib‐resistant NSCLC. This findings reveal a novel mechanism of oncogenic miRISC regulation by TBK1‐mediated pS417‐AGO2 and suggest potential therapeutic approaches for NSCLC. [ABSTRACT FROM AUTHOR]

Microorganisms play an important role in plant growth and development. In particular, endophytic fungi is one of the important kinds of microorganisms and has a mutually beneficial symbiotic relationship with host plants. Endophytic fungi have many substantial benefits to host plants, especially for woody plants, such as accelerating plant growth, enhancing stress resistance, promoting nutrient absorption, resisting pathogens and etc. However, the effects of endophytic fungi on the growth and development of woody plants have not been systematically summarized. In this review, the functions of endophytic fungi for the growth and development of woody plants have been mainly reviewed, including regulating plant growth (e.g., flowering, root elongation, etc.) by producing nutrients and plant hormones, and improving plant disease, insect resistance and heavy metal resistance by producing secondary metabolites. In addition, the diversity of endophytic fungi could improve the ability of woody plants to adapt to adverse environment. The components produced by endophytic fungi have excellent potential for the growth and development of woody plants. This review has systematically discussed the potential regulation mechanism of endophytic fungi regulating the growth and development of woody plants, it would be of great significance for the development and utilization of endophytic fungi resource from woody plants for the protection of forest resources. [ABSTRACT FROM AUTHOR]

Due to their atomically dispersed active centers, single‐atom nanozymes (SAzymes) have unparalleled advantages in cancer catalytic therapy. Here, loaded with chlorin e6 (Ce6), a hydrothermally mass‐produced bimetallic silicate‐based nanoplatforms with atomically dispersed manganese/gadolinium (Mn/Gd) dual sites and oxygen vacancies (OVs) (PMnSAGMSNs‐V@Ce6) is constructed for tumor glutathione (GSH)‐triggered chemodynamic therapy (CDT) and O2‐alleviated photodynamic therapy. The band gaps of silica are significantly reduced from 2.78 to 1.88 eV by doping with metal ions, which enables it to be excited by a 650 nm laser to produce electron‐hole pairs, thereby facilitating the generation of reactive oxygen species. The Gd sites can modulate the local electrons of the atom‐catalyzed Mn sites, which contribute to the generation of superoxide and hydroxyl radicals (•OH). Tumor GSH‐triggered Mn2+ release can convert endogenous H2O2 to •OH and realize GSH‐depletion‐enhanced CDT. Significantly, the hydrothermally generated OVs can not only capture Mn and Gd atoms to form atomic sites but also can elongate and weaken the O‐O bonds of H2O2, thereby improving the efficacy of Fenton reactions. The degraded Mn2+/Gd3+ ions can be used as tumor‐specific magnetic resonance imaging contrast agents. All the experimental results demonstrate the great potential of PMnSAGMSNs‐V@Ce6 as cancer theranostic agent. [ABSTRACT FROM AUTHOR]

Background: Lateral wall fractures represent crucial risk factors for postoperative internal fixation failure in intertrochanteric femoral fractures. However, no consensus exists on the type of lateral wall fracture requiring interventional management. This study aimed to investigate the effect of residual lateral wall volume on the postoperative stability of intertrochanteric femur fractures with associated lateral wall fractures, providing valuable reference for the clinical management of the lateral wall. Methods: Eleven bone defect models of intertrochanteric femur fractures with varying residual lateral wall volumes were constructed using finite element analysis. These models were fixed with proximal femoral nail antirotation (PFNA). Simulations of von Mises stress and displacement distribution of the PFNA and femur during normal walking were conducted. Statistical analysis was performed to assess the correlation between volume and the maximum von Mises stresses and displacements of the PFNA and femur. Results: In all 11 models, the maximum von Mises stress and displacement of the helical blade, intramedullary nail, and femur occurred at the same locations. As residual lateral wall volume increased, the maximum von Mises stress and displacement of the helical blade, intramedullary nail, and maximum femoral displacement gradually decreased. However, the overall trend of the maximum femoral von Mises stress gradually decreased. At 70% retention of the residual lateral wall volume, there was a more pronounced change in the value of the maximum stress change of the helical blade and the intramedullary nail. Statistical analysis, including the Shapiro–Wilk test and Pearson correlation analysis, demonstrated a significant negative correlation between volume and the maximum von Mises stress and displacement of the helical blade, intramedullary nail, and femur. Linear regression analysis further confirmed this significant negative correlation. Conclusion: Finite element analysis of the residual lateral wall revealed a significant correlation between volume and the postoperative stability of intertrochanteric femur fractures. A volume of 70% may serve as the threshold for stabilizing the residual lateral wall. Volume emerges as a novel index for evaluating the strength of the residual lateral walls. [ABSTRACT FROM AUTHOR]

The microRNAs, which are small RNAs of 18–25 nt in length, act as key regulatory factors in posttranscriptional gene expression during plant growth and development. However, little is known about their regulatory roles in response to stressful environments in birch (Betula platyphylla). Here, we characterized and further explored miRNAs from osmotic- and salt-stressed birch. Our analysis revealed a total of 190 microRNA (miRNA) sequences, which were classified into 180 conserved miRNAs and 10 predicted novel miRNAs based on sequence homology. Furthermore, we identified Bp-miR408a under osmotic and salt stress and elucidated its role in osmotic and salt stress responses in birch. Notably, under osmotic and salt stress, Bp-miR408a contributed to osmotic and salt tolerance sensitivity by mediating various physiological changes, such as increases in reactive oxygen species accumulation, osmoregulatory substance contents and Na+ accumulation. Additionally, molecular analysis provided evidence of the in vivo targeting of BpBCP1 (blue copper protein) transcripts by Bp-miR408a. The overexpression of BpBCP1 in birch enhanced osmotic and salt tolerance by increasing the antioxidant enzyme activity, maintaining cellular ion homeostasis and decreasing lipid peroxidation and cell death. Thus, we reveal a Bp-miR408a – BpBCP1 regulatory module that mediates osmotic and salt stress responses in birch. [ABSTRACT FROM AUTHOR]

Summary: Aluminium (Al) toxicity decreases crop production in acid soils in general, but many crops have evolved complex mechanisms to resist it. However, our current understanding of how plants cope with Al stress and perform Al resistance is still at the initial stage. In this study, the citrate transporter CcMATE35 was identified to be involved in Al stress response. The release of citrate was increased substantially in CcMATE35 over‐expression (OE) lines under Al stress, indicating enhanced Al resistance. It was demonstrated that transcription factor CcNFYB3 regulated the expression of CcMATE35, promoting the release of citrate from roots to increase Al resistance in pigeon pea. We also found that a Long noncoding RNA Targeting Citrate Synthase (CcLTCS) is involved in Al resistance in pigeon pea. Compared with controls, overexpression of CcLTCS elevated the expression level of the Citrate Synthase gene (CcCS), leading to increases in root citrate level and citrate release, which forms another module to regulate Al resistance in pigeon pea. Simultaneous overexpression of CcNFYB3 and CcLTCS further increased Al resistance. Taken together, these findings suggest that the two modules, CcNFYB3‐CcMATE35 and CcLTCS‐CcCS, jointly regulate the efflux and synthesis of citrate and may play an important role in enhancing the resistance of pigeon pea under Al stress. [ABSTRACT FROM AUTHOR]

Summary: Glycine‐rich RNA‐binding proteins (GRPs) have been implicated in the responses of plants to environmental stresses, but the function of GRP genes involved in salt stress and the underlying mechanism remain unclear. In this study, we identified BpGRP1 (glycine‐rich RNA‐binding protein), a Betula platyphylla gene that is induced under salt stress. The physiological and molecular responses to salt tolerance were investigated in both BpGRP1‐overexpressing and suppressed conditions. BpGRF3 (growth‐regulating factor 3) was identified as a regulatory factor upstream of BpGRP1. We demonstrated that overexpression of BpGRF3 significantly increased the salt tolerance of birch, whereas the grf3‐1 mutant exhibited the opposite effect. Further analysis revealed that BpGRF3 and its interaction partner, BpSHMT, function upstream of BpGRP1. We demonstrated that BpmiR396c, as an upstream regulator of BpGRF3, could negatively regulate salt tolerance in birch. Furthermore, we uncovered evidence showing that the BpmiR396c/BpGRF3 regulatory module functions in mediating the salt response by regulating the associated physiological pathways. Our results indicate that BpmiR396c regulates the expression of BpGRF3, which plays a role in salt tolerance by targeting BpGRP1. [ABSTRACT FROM AUTHOR]

Summary: As a multifunctional hormone‐like molecule, melatonin exhibits a pleiotropic role in plant salt stress tolerance. While actin cytoskeleton is essential to plant tolerance to salt stress, it is unclear if and how actin cytoskeleton participates in the melatonin‐mediated alleviation of plant salt stress. Here, we report that melatonin alleviates salt stress damage in pigeon pea by activating a kinase‐like protein, which interacts with an actin‐depolymerizing factor. Cajanus cajan Actin‐Depolymerizing Factor 9 (CcADF9) has the function of severing actin filaments and is highly expressed under salt stress. The CcADF9 overexpression lines (CcADF9‐OE) showed a reduction of transgenic root length and an increased sensitivity to salt stress. By using CcADF9 as a bait to screen an Y2H library, we identified actin depolymerizing factor‐related phosphokinase 1 (ARP1), a novel protein kinase that interacts with CcADF9. CcARP1, induced by melatonin, promotes salt resistance of pigeon pea through phosphorylating CcADF9, inhibiting its severing activity. The CcARP1 overexpression lines (CcARP1‐OE) displayed an increased transgenic root length and resistance to salt stress, whereas CcARP1 RNA interference lines (CcARP1‐RNAi) presented the opposite phenotype. Altogether, our findings reveal that melatonin‐induced CcARP1 maintains F‐actin dynamics balance by phosphorylating CcADF9, thereby promoting root growth and enhancing salt tolerance. [ABSTRACT FROM AUTHOR]

As a 'superfruit', the sour and astringent flavor of lingonberries seriously limits consumer acceptance and unravelling the intrinsic link between specific flavor and chemical constituents is urgent. This study proposed a comparative qualitative and quantitative analysis for flavor and functional phytochemicals in lingonberry fruits based on UHPLC-QqQ-MS/MS in multiple reaction monitoring (MRM). After systematic MRM parameters optimization, the developed method showed good precision (RSD < 4.4%) and recovery (99.89 ∼ 105.21%) within 6 min. The results revealed the distribution of 18 flavor and functional components of lingonberries during different ripening periods. In addition, it was surprisingly found that citric acid (7.94–15.58 mg/g DW) and (+)-catechin (0.52–4.13 mg/g DW) were the components contributing to the sour and astringent flavor of lingonberries, cyanidin-3- O -galactoside (0.48–4.17 mg/g DW) was the primary component affecting color, and benzoic acid (3.67–19.45 mg/g DW) was the typical functional component. Furthermore, biosynthetic gene transcript levels showed positive correlations with the chemical composition metabolic profile in lingonberry fruits at different ripening stages. In conclusion, this work provided a rapid and sensitive analysis and the dynamic changes of flavor and functional phytochemicals for quality control, optimal harvesting time and application of lingonberry fruits. [Display omitted] • Quality control analysis of lingonberry fruits based on UHPLC-QqQ-MS/MS method. • The main chemical components of flavor and function were revealed and compared. • The gene expression levels clarified the metabolite profiles during ripening. • This study provided the basic of application on lingonberry fruits. [ABSTRACT FROM AUTHOR]

Pinolenic acid is a polyunsaturated fatty acid present only in Pinus koraiensis Sieb. et Zucc seed oil. In order to solve the structural instability problem of polyunsaturated fatty acids, pinolenic acid of P. koraiensis seed oil was effectively isolated and purified by the integrated strategy of ethyl esterification followed by urea inclusion for the first time. Under the optimal conditions after the Box-Benhnken Design experimental, ethyl pinolenate with high purity 94.95% could be obtained, and the average content of PNAEE can still reach 86.18%. Then ethyl pinolenate was characterized by Gas chromatography-mass spectrometry, Fourier transform infrared, and Nuclear magnetic resonance spectra, results showed that ethyl pinolenate was successfully prepared. In addition, the hypolipidemic activity of ethyl pinolenate had been tested in vivo and showed that ethyl pinolenate had obvious hypolipidemic activity. The new strategy for high purity ethyl pinolenate production from P. koraiensis seed oil possesses great potential in food healthy field in the future. Diagram 1. The schematic synthesis process of PNAEE and its hypolipidemic activity evaluation. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] • DOX&ICG@H-ZIF-8@CaCO 3 -PEG NPs very high drug loading due to hollow structure. • π-π stacking effect of ICG and DOX increases drug stability. • The system has shown synergistic effects of pH sensitivity, photothermal, and calcium overload synergistic effects in vitro. In this study, we synthesized DOX-loaded H-ZIF-8@CaCO 3 -PEG nanocarrier, which combined with calcium overload and photothermal therapy (PTT) for synergistic therapy. The nanocarrier comprised a PEG modified calcium carbonate (CaCO 3) shell and a hollow imidazolate zeolite skeleton (H-ZIF-8) core, in which the chemotherapy drug doxorubicin hydrochloride (DOX) and photosensitizer indocyanine green (ICG) were simultaneously co-loaded. In vitro cellular experiments revealed that the lethality of DOX&ICG@H-ZIF-8@CaCO 3 -PEG against tumor cells was significantly higher than that of the single chemotherapy owing to the combination with chemotherapy and photothermal therapy as well as calcium overloading. This drug-loaded nanocarrier exhibits notable characteristics such as exceptional stability, elevated drug loading capacity and efficient release of the loaded drug, which provides a promising perspective for efficient synergistic therapy. [ABSTRACT FROM AUTHOR]

Phenylalanine, as an essential aromatic amino acid, is not only needed for protein and vital molecules such as neurotransmitter and hormone synthesis but also a substrate for the biosynthesis of phenylpropanoids and various bioactive compounds. The metabolism of phenylalanine is dynamic and transitory, which would otherwise inhibit cell growth. Therefore, it is challenging and imperative to monitor intracellular phenylalanine bioavailability in real time, which has great significance for evaluating the effectiveness of introducing pathway-specific genetic modifications to enhance phenylalanine generation. In this study, we proposed a live-cell biomonitoring system to assess phenylalanine bioavailability in real time in cyanobacteria based on codon degeneracy and species-specific usage bias. The biomonitoring system was generated through genetic modification of phenylalanine codons in the chloramphenicol antibiotic resistance gene to wholly preferred and rare codons, in combination with an orthogonal constitutive promoter Trc to express these genes. Cyanobacterial cells equipped with a preferred codon-based gene showed a significant growth advantage over those with rare codons under antibiotic pressure, while the delayed growth caused by rare codon-based genes could be rescued by supplementing phenylalanine in the cultivation medium. Increasing intracellular phenylalanine bioavailability could promote rare codon-based gene containing cell growth to a similar level as wild-type strains harboring preferred codon-based gene, providing a live-cell visualized screening method to relatively define phenylalanine content from either random mutation libraries or pathway-specific engineering cyanobacterial chassis before conducting labor-intensive quantitative measurements. [Display omitted] [ABSTRACT FROM AUTHOR]

An oleanolic acid (OA) surface molecularly imprinted polymer silylated porous composite aerogels (OA-MIP@Si-PC-aerogels) adsorbent material was successfully prepared and characterized. The material not only has a great selectivity for the target molecule OA but also has other noteworthy qualities including high stability, excellent repeatability, and a sizable adsorption capacity. via cellulose and sodium alginate as the main materials, the carrier Si-PC-aerogels were made through ionic cross-linking, chemical cross-linking, and silylation procedures. By adopting a surface molecular imprinting approach on Si-PC-aerogels, OA-MIP@Si-PC-aerogels were effectively created utilizing OA as the template molecule and MAA as the functional monomer. Due to the presence of a specific imprinted layer on the aerogel surface, the adsorption capacity of OA-MIP@Si-PC-aerogels for OA could reach 66.20 mg g−1. OA-MIP@Si-PC-aerogels could achieve a 68.86% yield of OA from the extracts of lingonberry (Vaccinium Vitis-Idaea L.). The adsorption capacity remained at 90% after five consecutive adsorption-desorption cycles. HepG2 cells were exposed to OA that was effectively enriched with OA-MIP@Si-PC-aerogels in lingonberry (Vaccinium Vitis-Idaea L.) fruit homogenates. This OA significantly inhibited the growth of HepG2 cells in vitro. It further demonstrated that OA-MIP@Si-PC-aerogels could efficiently target OA enrichment and separation with good recovery. [Display omitted] • Silanized porous composite aerogel (Si-PC-aerogels) were preparaed successfully. • OA-MIP@Si-PC-aerogels with stable recyclability is green, economic and low-toxic. • Application of OA-MIP@Si-PC-aerogels in efficient targeted extraction of oleanolic acid. • Oleanolic acid extracted from OA-MIP@Si-PC-aerogels inhibits the growth of HepG2 cells. [ABSTRACT FROM AUTHOR]

Heavy metal ions' high toxicity, carcinogenicity, and non-degradability have been identified as the most severe environmental concerns. Therefore, in this study, a new type of cellulose-based ionic imprinting adsorbent (p-CMs@EPI@PEI@Cys-IIP) with a three-dimensional pore structure was developed to selectively adsorb cobalt (II) using a simple ion-cross-linking technique. In this experiment, p-CMs@EPI@PEI@Cys-IIP were prepared by modifying cellulose microspheres (p-CMs) with epichlorohydrin (EPI), polyethyleneimine (PEI) and L-cysteine (L-Cys). The p-CMs@EPI@PEI@Cys-IIP was found to be able to selectively adsorb Co (II), and it was well characterized with FT-IR, SEM, TGA, and XRD. The system adsorption experiment proved that the maximum adsorption capacity reached 158.93 mg g-1, below the pH 7. After five cycles, the adsorption capacity of p-CMs@EPI@PEI@Cys-IIP still remained above 90%. The results of selectivity experiments indicated that p-CMs@EPI@PEI@Cys-IIP has preferential selectivity for Co (II). The adsorption isotherm and kinetic experiment of Co (II) conformed to the Langmuir model and pseudo-second-order kinetic, respectively. The adsorption process of Co (II) on p-CMs@EPI@PEI@Cys-IIP was also affected by the intra-particle diffusion model. Due to its simple preparation method and good adsorption performance, p-CMs@EPI@PEI@Cys-IIP would have a good application prospect in the selective removal of Co (II) for water treatment. The schematic synthesis process of p-CMs and p-CMs@EPI@PEI@Cys. [Display omitted] • Cellulose-based ion-imprinted adsorbents were prepared using absorbent cotton. • Cellulose-based ion-imprinted adsorbents can selectively adsorb Co (II). • Cellulose-based ion-imprinted adsorbent can adsorb 158.93 mg g−1. • Cellulose-based ion-imprinted adsorbents have reusability. [ABSTRACT FROM AUTHOR]