Search

Verogen Inc. has submitted a patent application for a new method of DNA-based kinship analysis. The method involves amplifying a nucleic acid sample using specific primers that target thousands of single nucleotide polymorphisms (SNPs), generating a DNA profile, and calculating the degree of relationship to reference DNA profiles. This method is designed for forensic purposes and can be used with low-quality and low-quantity DNA samples. The patent application also includes information on constructing a nucleic acid library and the use of enzyme inhibitors. The methods described in the patent application can be used with various types of nucleic acid samples and include different types of SNPs. [Extracted from the article]

A patent has been issued to Cerner Innovation Inc. for a technology that applies Electronic Clinical Quality Measures (eCQM), Pay-for-Performance (P4P) measures, Meaningful Use (MU), or similar measures in a fantasy league exchange for health services. The technology utilizes statistical regression and parallelized methods to establish performance rankings of healthcare providers. These rankings can be used in a fantasy health exchange system for making decisions regarding draft picks, roster submission, or bets. The technology aims to improve the quality, access, and cost-effectiveness of health services. [Extracted from the article]

A patent application titled "Canopy Device And Child Carrier Having The Same" has been published online by the US Patent and Trademark Office. The patent application, filed by inventor Jennifer E. Sheldrick, aims to address the need for a child carrier canopy that can quickly and easily store a net or other coverings. The canopy device includes a shielding portion, an accommodating portion with an opening, and another shielding portion that can be received in the accommodating portion. The invention aims to provide a simple and aesthetically pleasing solution to the storage of coverings in child carriers. The assignee for this patent application is Wonderland Switzerland AG. [Extracted from the article]

A patent has been issued for a modular smokable product packaging system and method. The patent describes a system that addresses the challenges of measuring, preparing, and packaging ready-made smokable products containing cannabis. The system includes a centrifuge with a drive assembly, dynamic positioning talon assemblies, and pod assemblies. It aims to efficiently, accurately, and consistently measure and fill commercially viable quantities of article cones with smokable herb, as well as uniformly compress and package ready-made smokable products. The patent was filed by Eric Grigsby and assigned to KungTech LLC. [Extracted from the article]

A patent has been issued for a filler material used in smoking articles that contains blends of aerosol generating materials. The patent addresses the challenges of controlling the amount of active compounds, such as nicotine, delivered to users while maintaining good sensory characteristics. The invention involves a reconstituted plant material that combines fibers from different plant sources, such as cannabis, tobacco, and herbal plants. The material can also include web building fibers and be treated with a humectant. The patent provides various embodiments and claims for the aerosol generating material and its use in smoking articles. [Extracted from the article]

BetaPod Inc. has been issued a patent for a system that includes a machine for preparing a smokable product from a portion capsule. The patent describes a capsule containing smokeable material, such as cannabis, and a machine that uses the capsule to create a smokeable product rolled in a rolling medium. The capsule has a bowl-shaped body with an open top and a rounded bottom, and a circular disc seals the top. The machine includes a tamper to puncture the capsule and transfer the smokeable material into the rolling medium. The patent also mentions the option for the capsule and disc to be made from biodegradable material. [Extracted from the article]

AIRLINE INDUSTRY INFORMATION-(C)1997-2024 M2 COMMUNICATIONS The Digital Map Market is expected to grow from USD 28.3 bn in 2024 to USD 47.8 bn by 2029 at a Compound Annual Growth [...]

HanxBio has published a research paper titled "Narazaciclib, a novel multikinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models" in the journal Scientific Reports. The paper describes the preclinical evaluation of Narazaciclib (HX301) for the treatment of acute myeloid leukemia (AML). The researchers conducted comprehensive pharmacology characterization of HX301 using various preclinical experimental AML models, demonstrating its strong anti-leukemia activity and potential mechanisms of action. The study also investigated the pharmacodynamics and pharmacokinetics of HX301, providing valuable information for clinical dosage selection. The results of this study will guide the clinical development strategies for HX301 in the treatment of AML. [Extracted from the article]

A recent study conducted by GlaxoSmithKline plc highlights the transformative impact of microsampling and patient-centric sampling (PCS) techniques in drug development and clinical trials. These techniques have revolutionized pharmaceutical research by reducing sample volume requirements, allowing sample collection at home or nontraditional sites, and minimizing patient burden. The study also discusses the integration of liquid chromatography-mass spectrometry (LC-MS) strategies for analyzing PCS samples and addresses the challenges and future directions of implementing PCS. The aim of this research is to enhance patient care and treatment efficacy by fostering patient-centric approaches in pharmaceutical sciences. [Extracted from the article]

Autolomous, a developer of manufacturing management systems for cell and gene therapies, has partnered with BioCentriq, a clinical-phase Cell Therapy CDMO, to digitize and accelerate process development and manufacturing activities. Autolomous' autoloMATE platform is a cloud-native software designed to improve efficiency and data integrity in the cell and gene therapy sector. BioCentriq will use the autoloMATE platform to streamline its operations and enhance the client experience, ultimately speeding up the delivery of cutting-edge cell therapies to patients. This collaboration aims to revolutionize healthcare innovation and make life-saving therapies more accessible to those in need. [Extracted from the article]

A study conducted by Merck & Company in Rahway, New Jersey, explores the development and validation of a cell-based binding neutralizing antibody assay for an antibody-drug conjugate (ADC). ADCs have gained attention in targeted cancer therapy due to their ability to combine the specificity of monoclonal antibodies and the potency of small molecular drugs. The research found that a cell-based killing assay could not be developed as expected, and instead, a novel cell-based binding assay was implemented. The study concludes that the in vitro cell killing NAb assay is limited in mimicking the in vivo mechanism of action of ADCs. [Extracted from the article]

Researchers from Dow Chemical Company have published a study on the quantification of evidence for active signals in genomic applications related to obesity, fitness, and wellness. The study focuses on a sparse-limit approximation for T-statistics, specifically looking at the effect of low degrees of freedom on the Bayes factor. The researchers illustrate their findings using a HIV dataset for gene-expression data. For more information, readers can refer to the article "Sparse-limit Approximation for T-statistics" published in the Electronic Journal of Statistics. [Extracted from the article]

Exostar, a company specializing in secure business collaboration solutions for regulated industries, has announced the appointment of Dr. Rick Simpson as Chief Finance Officer. Dr. Simpson brings 30 years of relevant experience, including 20 years as a CFO, and has a track record of success in helping companies achieve their growth objectives. He will play a key role in developing business strategies and overseeing financial activities, as well as planning and integrating acquisitions. Exostar aims to continue its growth and deliver on its promise to customers. [Extracted from the article]

A patent has been issued for a method of moving a stack of products using a robot. The invention aims to automate the process of moving and depositing stacks of printed products. The method involves pivoting the stack of products into a vertical position using a separate pivoting device, then pivoting it further using the robot. The invention allows for selective turning of the stack and includes additional steps such as aligning, straightening, vibrating, and modifying the stack. The method can be fully automated and adapted to the production speed of the machines used. The patent was assigned to Heidelberger Druckmaschinen AG. [Extracted from the article]

A patent has been issued for a shower towel set equipped with a holder. The inventor, Yoo, Jun Ho, filed the patent on April 16, 2020, and it was published online on April 9, 2024. The assignee for this patent is Bbtto Corporation. The invention aims to address the limitations of conventional scrubbing towels by providing a flexible fabric material that is gentle on the skin, generates a lot of foam, and allows for the temporary storage of soap or shower detergents. The shower towel set includes a shower towel with a separate space for soap storage and a holder for drying and storing the towel. The materials used for the towel and holder are primarily silicone with a small percentage of cockleshell. The patent provides detailed descriptions and claims for the design and features of the shower towel set. [Extracted from the article]

A patent has been issued to Johnson & Johnson GmbH for a tampon press that shapes tampons into a more comfortable and effective design. The press uses a central cavity and a plurality of penetrating dies to shape the tampon blank into a tampon pledget with a shaped longitudinal profile and an elliptical cross section. The press can be used to create tampons that better fit the wearer's anatomy, reducing discomfort and leakage. The patent provides detailed descriptions and claims for the press design. [Extracted from the article]

The USPTO has published a patent application titled "Writing System" by inventors Ion-Ioannis Antonakis and Nikolaos Chrysanthakopoulos, assigned to BIC Violex Single Member S.A. The application describes a computer-based method for monitoring eye-hand coordination during writing to identify potential neurodegeneration and cognitive impairment. The system tracks the user's eye movements and pen location, generating data on eye and handwriting performance. If the user's performance deviates significantly from their historical data, they are alerted through a mobile device or tactile feedback mechanism. The system incorporates sensors, a communication system, a computer system, and a storage system. [Extracted from the article]

A patent has been issued to Blue Goji LLC for a health-related data collection system for healthcare diagnostics and treatment platforms. The system involves a cloud-based gaming platform that captures data about a user's physical and mental performance while they exercise on compatible equipment and engage in a virtual reality environment. The system aims to provide a means for identifying and treating neurological conditions, including early cognitive decline and neurological disorders such as dementia. It also addresses the lack of adherence to medical recommendations and prescriptions by integrating treatment regimens into the gaming platform. [Extracted from the article]

A patent application titled "Optimized Thermal Bottle" has been published online by the US Patent and Trademark Office. The inventor, Elvira GUALTIERI, filed the application on August 31, 2021, and the assignee is Pegaf S.R.L. The patent application describes an optimized thermal bottle that can independently manage multiple drinks or solid foods within separate compartments, allowing for different storage temperatures. The bottle consists of thermos compartments that are adjacent and can be closed with a cap. The invention aims to overcome the limitations of current thermal bottles and provide improved thermal insulation for each compartment. [Extracted from the article]

A patent has been issued for a carton designed to hold food products. The patent, filed by inventor John Murdick Holley Jr., describes a tray with multiple panels that form a rim, as well as foldable end flaps. The tray can be formed from a blank and includes features for product visibility. The patent was assigned to Graphic Packaging International LLC. [Extracted from the article]

A research paper titled "Evidence of a pan-tissue decline in stemness during human aging" has been published in the journal Aging. The study, conducted by researchers from the Universidade de Sao Paulo, University of Birmingham, and the University of Liverpool, used a machine learning method to analyze transcriptome data from healthy human tissues. The researchers found that approximately 60% of the tissues studied showed a negative correlation between age and stemness score, indicating a decline in stem cell function with aging. However, the uterus was an exception, showing increased stemness with age. The study suggests that stem cell deterioration may contribute to human aging. [Extracted from the article]

The downdraught of the helicopter's rotor blades, as it landed, blew her and her tripod sheer off the ground. Smoke from earth-shaking explosions shut down her view entirely. A trek [...]

Ingesan, a subsidiary of the OHLA Infrastructure Group, the Madrid-based construction and concession management multinational, has launched the Empath-IA project, a joint initiative between HR management and the digital transformation [...]

Every kitchen holds tradition, weaving together rich cultures and meals made with love. For home cook Yumna Jawad, tradition is a cornerstone of her cooking philosophy. Her new cookbook, The [...]

BUYING: Look for firm peppers with a glossy sheen and zero soft spots.STORAGE: Place whole unwashed peppers in paper bag in crisper drawer of fridge for up to 7 days.FYI: [...]

STORAGE: Refrigerate unwashed fruit on paper towels in an uncovered container (to keep moisture from forming).BUYING: Look for bright green stems and firm, shiny skins.FYI: Polyphenol antioxidants in cherries help [...]

Mixed Berry Dutch BabySee page 68 for recipe.Eggs BenedictSee page 68 for recipe. TIP Chopping herbs with a knife can send them scattering all over. Instead, place them in a [...]

Peanut Butter BlondiesSee page 73 for recipe. Poached Apricots with MascarponeSee page 73 for recipe.Flourless Chocolate CakeSee page 73 for recipe. Peanut Butter Blondies Active time: 45 min. Total time: [...]

What’s hot now This Mother’s Day, top florists are presenting rose mixes in luxe layered wraps—and the results are lovely! “Here, soft pastel-hued blooms lend a timeless elegance that’s perfect [...]

REVITALIZE GARDEN SHEARS IN A SNIP Dull shears can make pruning both indoor and outdoor greenery quite the hassle. To get them working like new again, enlist the help of [...]

—Kira Davis, Shoshoni, WY “My living room floor squeaks whenever I walk on it, and when I brought it up to a friend, she recommended pouring talcum-free baby powder on [...]

Jacksonville is known as a logistics hub, which includes railroads like CSX and Florida East Coast Railway, both headquartered there. Yet other railroads, like Norfolk Southern, also have a large [...]

Local efforts to find a buyer for the closed Foley Cellulose Paper Mill in Perry have been put on hold for another year while owner Georgia Pacific conducts a study [...]

From a humble start, attorney John Ruiz became Florida's richest person--on paper, for a moment. Now the medical claims recovery company that catapulted him to billionaire status is on the [...]

Fort Myers * Bonita Springs Estero * Cape Coral * Sanibel & Captiva Islands * Fort Myers Beach Pine Island * North Fort Myers Lehigh Acres * Boca Grande & [...]

THE DOE WASN'T HUGE, but we were getting down to the end of the season and I was a bit light on my self-imposed rule: 'Take at least one doe [...]

Byline: David Burrows 'Today marks another significant moment and an industry first,' wrote Shiada Drysdale, beverages manager at Virgin Atlantic in March. 'For the past couple of years [we] have [...]

Trempe, Melissa LADYBUG LAUNCH McElderry (Children's None) $18.99 4, 16 ISBN: 9781665930406 In this tale inspired by co-author Ojeda's personal experience, kindred spirits reach for the stars. Natalia, a young [...]

El-Rouby, Yasmin MISTY MOLE GETS NEW GLASSES Neem Tree Press (Children's None) $18.95 6, 11 ISBN: 9781915584182 Misty Mole realizes that her eyesight needs correcting. Misty's friend Sunny Squirrel says [...]

Schmuhl, Robert MR. CHURCHILL IN THE WHITE HOUSE Liveright/Norton (NonFiction None) $32.00 7, 2 ISBN: 9781324093428 A respected historian finds new things to say about the relationship between Franklin Roosevelt [...]

Scanlon, Liz Garton BIBSY CROSS AND THE BAD APPLE Knopf (Children's None) $16.99 6, 11 ISBN: 9780593644416 Trouble with an insensitive teacher threatens an enthusiastic 8-year-old's love of school in [...]

Saller, Carol Fisher MADDIE'S GHOST (Fiction) $21.99 8, 15 ISBN: 9798986235387 In Saller's middle-grade novel, a tween and her friends race against time to restore her great-grandmother's good name. The [...]