Search

Burns cause a loss of skin barrier function, rendering it prone to infection. The prevention of infection comprises a focus on the treatment of patients with burns. Therefore, we analysed the results of microbiological tests of patients with severe and extremely severe burns to provide a basis for the prevention and treatment of infection in patients with burns. The results of microbiological tests of patients with severe and extremely severe burns admitted to our burn centre between 2009 and 2019 were retrospectively reviewed. The overall positive rate of microbial detection was 40.67% and did not significantly decline over the 10-year study period. The most common positive sites were wounds, sputum, and urine. The most common bacterial species causing the infections were Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Furthermore, the predictors of a positive detection, overall and at various sites, mainly included the burn area and depth, inhalation injury, and length of the hospital stay. Positive detection was an important predictor of the prognosis. In particular, a positive blood culture and Klebsiella pneumoniaehad better predictive strength for mortality than other sites and strains. This study analysed the microbiological testing results at a single burn centre over a period of 10 years. The results provide information regarding the predictors of a positive detection and the influence of a positive detection on prognosis, and can be used as a basis for the development of clinical infection prevention and treatment strategies, as well as the selection of treatment measures.

A retrospective study conducted by Naval Medical University in Shanghai, China aimed to provide a comprehensive understanding of degloving skin and soft tissue injuries (DSTI) in China. The study analyzed data from 62,709 patients hospitalized between 2013 and 2018, focusing on demographics, injury characteristics, hospitalization, and cost information. The study found that DSTI predominantly affected males, with a mean age of 43.01 years, and peasants were the most vulnerable group. Traffic-related accidents and the summer season were the most common causes of injury. The study concluded that the findings could contribute to improved prevention and treatment strategies for DSTI. [Extracted from the article]

Keywords: Blood Cells; Blood Diseases and Conditions; Bloodstream Infection; Bone Marrow Cells; Cell Research; Drugs and Therapies; Genetics; Genomics; Health and Medicine; Hemic and Immune Systems; Immunology; Monocytes; Mononuclear Leukocytes; Mononuclear Phagocyte System; Myeloid Cells; Phagocytes; Pharmaceuticals; RNA Research; Sepsis; Septicemia EN Blood Cells Blood Diseases and Conditions Bloodstream Infection Bone Marrow Cells Cell Research Drugs and Therapies Genetics Genomics Health and Medicine Hemic and Immune Systems Immunology Monocytes Mononuclear Leukocytes Mononuclear Phagocyte System Myeloid Cells Phagocytes Pharmaceuticals RNA Research Sepsis Septicemia 291 291 1 07/10/23 20230714 NES 230714 2023 JUL 13 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- New study results on sepsis have been published. ScRNA-seq analysis of human sepsis revealed substantial heterogeneity in monocyte compartments following the onset of sepsis, for which distinct monocyte subsets were enriched in disparate subclusters of septic patients. [Extracted from the article]