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Your search keyword '"van der Zwan, Ellen"' showing total 6 results
Start Over Author "van der Zwan, Ellen" Publication Type Electronic Resources
6 results on '"van der Zwan, Ellen"'

1. Effect of bariatric surgery on NAFLD/NASH:a single-centre observational prospective cohort study

Author

Theel, Willy B., Boxma-De Klerk, Bianca M., Dirksmeier-Harinck, Femme, Van Rossum, Elisabeth F.C., Kanhai, Danny A., Apers, Jan A., Van Dalen, Bas M., De Knegt, Robert J., Neecke, Bojou, Van Der Zwan, Ellen M., Grobbee, Diederick E., Hankemeier, Thomas, Wiebolt, Janneke, Castro Cabezas, Manuel, Theel, Willy B., Boxma-De Klerk, Bianca M., Dirksmeier-Harinck, Femme, Van Rossum, Elisabeth F.C., Kanhai, Danny A., Apers, Jan A., Van Dalen, Bas M., De Knegt, Robert J., Neecke, Bojou, Van Der Zwan, Ellen M., Grobbee, Diederick E., Hankemeier, Thomas, Wiebolt, Janneke, and Castro Cabezas, Manuel

Abstract

Introduction The prevalence of non-alcoholic fatty liver disease (NAFLD) ranges from 25% in the general population to 90% in patients with obesity scheduled for bariatric surgery. NAFLD can progress towards non-alcoholic steatohepatitis (NASH) associated with complications such as cirrhosis, hepatocellular carcinoma and cardiovascular disease. To date, losing weight and lifestyle modifications are the best known treatments for NASH. Bariatric surgery significantly improves NAFLD/NASH in the short term. However, the extent of this improvement is not yet clear and long-term data on the natural course of NAFLD/NASH after bariatric surgery are lacking. The factors involved in NAFLD/NASH regression after bariatric surgery have not been elucidated. Methods and analysis This is an observational prospective cohort study including patients scheduled for bariatric surgery. Extensive metabolic and cardiovascular analyses will be carried out including measurements of carotid intima media thickness and pulse wave velocity. Genomic, proteomic, lipidomic and metabolomic studies will be done. Microbioma analyses before and 1 year after surgery will be done. Transient elastography measurements will be performed before and at 1, 3 and 5 years after surgery. For those with an elevated preoperative transient elastography measurement by Fibroscan, a laparoscopic liver biopsy will be performed during surgery. Primary outcome measures are the change of steatosis and liver fibrosis 5 years after surgery. Secondary outcome measure is the comparison of the transient elastography measurements with the NAFLD Activity Score from the biopsies. Ethics and dissemination The protocol has been approved by the Medical Research Ethics Committees United, Nieuwegein, on 1 March 2022 (registration code R21.103/NL79423.100.21). The study results will be submitted for publication in peer-reviewed journals and data will be presented at scientific meetings. Trial registration number NCT05499949.

Published
2023

2. Dynamics of Antibody and T Cell Immunity against SARS-CoV-2 Variants of Concern and the Impact of Booster Vaccinations in Previously Infected and Infection-Naïve Individuals

Author

Epi Infectieziekten Team 1, Infection & Immunity, Faas, Michel R, Mak, Willem A, Markus, Hilde Y, van der Zwan, Ellen M, van der Vliet, Marijke, Koeleman, Johannes G M, Ong, David S Y, Epi Infectieziekten Team 1, Infection & Immunity, Faas, Michel R, Mak, Willem A, Markus, Hilde Y, van der Zwan, Ellen M, van der Vliet, Marijke, Koeleman, Johannes G M, and Ong, David S Y

Published
2022

3. Effect of a single dose of Vitamin D3 on postprandial arterial stiffness and inflammation in Vitamin D-deficient women

Author

de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, Cabezas, Manuel Castro, de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, and Cabezas, Manuel Castro

Published
2017

4. Effect of a single dose of Vitamin D3 on postprandial arterial stiffness and inflammation in Vitamin D-deficient women

Author

de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, Cabezas, Manuel Castro, de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, and Cabezas, Manuel Castro

Published
2017

5. Effect of a single dose of Vitamin D3 on postprandial arterial stiffness and inflammation in Vitamin D-deficient women

Author

de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, Cabezas, Manuel Castro, de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, and Cabezas, Manuel Castro

Published
2017

6. Effect of a single dose of Vitamin D3 on postprandial arterial stiffness and inflammation in Vitamin D-deficient women

Author

Geboortecentrum voorzitterschap, Other research (not in main researchprogram), de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, Cabezas, Manuel Castro, Geboortecentrum voorzitterschap, Other research (not in main researchprogram), de Vries, Marijke A, Van Der Meulen, Noelle, van de Geijn, Gert-Jan M, Klop, Boudewijn, van der Zwan, Ellen M, Prinzen, Lenneke, Birnie, Erwin, Westerman, Elsbeth M, de Herder, Wouter W, and Cabezas, Manuel Castro

Published
2017

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