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8 results on '"van Rijn, S J"'

1. The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Author

Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, Penning, L C, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, and Penning, L C

Abstract

Pituitary-dependent hypercortisolism (PDH) is a common endocrinopathy in dogs, but the promotors and initiators of the tumourigenesis of corticotroph pituitary adenomas remain unknown. Based on human data, we investigated mRNA expression of pituitary tumour transforming gene 1 (PTTG1) with quantitative RT-PCR in canine corticotroph pituitary adenomas. PTTG1 was overexpressed in adenomas approximately 3-fold. A strong association was observed between PTTG1 expression and disease-free interval; dogs with high PTTG1 expression had a significantly (4 times; P=0.02) shorter disease-free interval than dogs with low PTTG1 expression. This paper shows that PTTG1 expression is a negative prognosticator in relation to disease-free interval and recurrence in dogs undergoing transsphenoidal hypophysectomy as treatment for PDH.

Published
2018

2. The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Author

Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, Penning, L C, Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, and Penning, L C

Published
2018

3. The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Author

Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, Penning, L C, Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, and Penning, L C

Published
2018

4. The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas

Author

Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, Penning, L C, Biochemisch laboratorium, Orthopedie en neurochirurgie, LS Algemene chirurgie, Onderzoek, dCSCA RMSC-1, dCSCA AVR, Vastenhout, N, van Rijn, S J, Riemers, F M, Tryfonidou, M A, Meij, B P, and Penning, L C

Published
2018

5. The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

Author

van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, Meij, B P, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, and Meij, B P

Abstract

BACKGROUND: Transsphenoidal hypophysectomy is an effective treatment for dogs with pituitary-dependent hypercortisolism (PDH). However, long-term recurrence of hypercortisolism is a well-recognized problem, indicating the need for reliable prognostic indicators.OBJECTIVES: The aim of this study was to evaluate the prognostic value of perioperative plasma ACTH and cortisol concentrations for identifying recurrence of hypercortisolism after transsphenoidal hypophysectomy.ANIMALS: A total of 112 dogs with PDH that underwent transsphenoidal hypophysectomy met the inclusion criteria of the study.METHODS: Hormone concentrations were measured preoperatively and 1-5 hours after surgery. Both absolute hormone concentrations and postoperative concentrations normalized to preoperative concentrations were included in analyses. The prognostic value of hormone concentrations was studied with Cox's proportional hazard analysis.RESULTS: Median follow-up and disease-free period were 1096 days and 896 days, respectively. Twenty-eight percent of patients had recurrence, with a median disease-free period of 588 days. Both absolute and normalized postoperative cortisol concentrations were significantly higher in dogs with recurrence than in dogs without recurrence. High ACTH 5 hours after surgery, high cortisol 1 and 4 hours after surgery, high normalized ACTH 3 hours after surgery, high normalized cortisol 4 hours after surgery and the random slope of cortisol were associated with a shorter disease-free period.CONCLUSIONS AND CLINICAL IMPORTANCE: Individual perioperative hormone curves provide valuable information about the risk of recurrence after hypophysectomy. However, because no single cutoff point could be identified, combination with other variables, such as the pituitary height/brain area (P/B) ratio, is still needed to obtain a good estimate of the risk for recurrence of hypercortisolism after hypophysectomy.

Published
2015

6. The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

Author

Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, Meij, B P, Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, and Meij, B P

Published
2015

7. The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

Author

Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, Meij, B P, Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, and Meij, B P

Published
2015

8. The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas

Author

Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, Meij, B P, Applied Veterinary Research, dCSCA AVR, dCSCA RMSC-1, Opleiding chirurgie, Sub Endocrinologie, Onderzoek, Sub Neuro/Tandheelkunde, LS Algemene chirurgie, Regenerative Medicine, Stem Cells & Cancer, van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A, and Meij, B P

Published
2015

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