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2 results on '"van Dijk KGJ"'

1. Incidence and outcome of acquired demyelinating syndromes in Dutch children: update of a nationwide and prospective study

Author

Mol, Louk, Wong, Yu Yi, van Pelt - T Gravesteijn, Elles, Ketelslegers, IA, Bakker, DP, Boon, M, Braun, KPJ, van Dijk, KGJ, Eikelenboom, MJ, Engelen, MP, Geleijns, K, Haaxma, C A, Niermeijer, JMF, Niks, EH, Peeters, EAJ, Peeters-Scholte, C, Poll-The, BT, Portier, RP, De Rijk-Van Andel, JF, Samijn, JPA, Schippers, HM, Snoeck, IN, Stroink, H, Vermeulen, RJ, Verrips, A, Visscher, F, Vles, JSH, Willemsen, M, Catsman - Berrevoets, Coriene, Hintzen, Rogier, Neuteboom, Rinze, Mol, Louk, Wong, Yu Yi, van Pelt - T Gravesteijn, Elles, Ketelslegers, IA, Bakker, DP, Boon, M, Braun, KPJ, van Dijk, KGJ, Eikelenboom, MJ, Engelen, MP, Geleijns, K, Haaxma, C A, Niermeijer, JMF, Niks, EH, Peeters, EAJ, Peeters-Scholte, C, Poll-The, BT, Portier, RP, De Rijk-Van Andel, JF, Samijn, JPA, Schippers, HM, Snoeck, IN, Stroink, H, Vermeulen, RJ, Verrips, A, Visscher, F, Vles, JSH, Willemsen, M, Catsman - Berrevoets, Coriene, Hintzen, Rogier, and Neuteboom, Rinze

Published
2018

2. Incidence of acquired demyelinating syndromes of the CNS in Dutch children: a nationwide study

Author

Ketelslegers, Immy, Catsman - Berrevoets, Coriene, Neuteboom, Rinze, Boon, M, van Dijk, KGJ, Eikelenboom, MJ, Gooskens, RHJM, Niks, EH (Erik), Overweg-Plandsoen, WCG, Peeters, EAJ, Peeters-Scholte, CMPCD, Poll-The, BT, De Rijk-Van Andel, JF, Samijn, JPA, Snoeck, IN, Stroink, H (Hans), Vermeulen, RJ, Verrips, A, Vles, JSH, Willemsen, MAAP, Pereira, RR, Hintzen, Rogier, Ketelslegers, Immy, Catsman - Berrevoets, Coriene, Neuteboom, Rinze, Boon, M, van Dijk, KGJ, Eikelenboom, MJ, Gooskens, RHJM, Niks, EH (Erik), Overweg-Plandsoen, WCG, Peeters, EAJ, Peeters-Scholte, CMPCD, Poll-The, BT, De Rijk-Van Andel, JF, Samijn, JPA, Snoeck, IN, Stroink, H (Hans), Vermeulen, RJ, Verrips, A, Vles, JSH, Willemsen, MAAP, Pereira, RR, and Hintzen, Rogier

Abstract

Acquired demyelinating syndromes (ADS) can be a first presentation of multiple sclerosis (MS) in children. The incidence of these disorders in Europe is currently unknown. Children (< 18 years old) living in the Netherlands who presented with ADS were included from January 1, 2007 to December 31, 2010 by the Dutch pediatric MS study group and the Dutch surveillance of rare pediatric disorders. Demographic and clinical data were collected. Eighty-six patients were identified over 4 years, resulting in an incidence of 0.66/1,00,000 per year. Most patients presented with polyfocal ADS without encephalopathy (30%), followed by polyfocal ADS with encephalopathy (24%), optic neuritis (ON, 22%), monofocal ADS (16%), transverse myelitis (3%), and neuromyelitis optica (3%). Patients with polyfocal ADS with encephalopathy were younger (median 3.9 years) than patients with ON (median 14.6 years, p < 0.001) or monofocal ADS (median 16.0 years, p < 0.001). Patients with polyfocal ADS without encephalopathy (median 9.2 years) were also younger than monofocal ADS patients (median 16.0 years, p < 0.001). There was a slight female preponderance in all groups except the ON group, and a relatively large number of ADS patients (29%) reported a non-European ancestry. Familial autoimmune diseases were reported in 23%, more often in patients with relapsing disease than monophasic disease (46 vs. 15%, p = 0.002) and occurring most often in the maternal family (84%, p < 0.001). During the study period, 23% of patients were subsequently diagnosed with MS. The annual incidence of ADS in the Netherlands is 0.66/1,00,000 children/year. A polyfocal disease onset of ADS was most common.

Published
2012

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