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With the growing demand for expanding sustainable energy production in the Netherlands, investigating potential renewable energy sources has become imperative. Scheduled replacement projects for weirs along the river Meuse within the next decade present an excellent opportunity to assess the feasibility of integrating hydropower plants into these future weirs. This thesis explores the feasibility of implementing hydropower plants in future weirs along the river Meuse, addressing criteria such as hydraulic aspects, impact on vessel navigation, fish migration, and economic viability. To achieve this objective, an initial case study was conducted, focusing on the development of a design for the weir replacement at Grave. Subsequently, the broader applicability of the developed design was explored to investigate large-scale implementation in the river Meuse. At the outset of this study, no specific design existed for the future weir at Grave. Therefore, the initial research phase concentrated on creating a future weir design for the Grave location. Following this, the optimal method for integrating a hydropower plant into this future weir was explored, employing the basic engineering design cycle as applied in civil engineering. The Archimedean screw turbine technology was selected, leading to the development of multiple hydropower plant designs using this technology. Initially, their direct integration into the weir was explored. However, it was determined that placing more than two of these turbines directly within the weir was hydraulically unfeasible, posing risks to water safety. To overcome this challenge, three potential implementation concepts were developed: temporary removable turbines, a hydropower plant in the floodplain, and turbine integration into weir pillars. The optimal design for integrating a hydropower plant into the future weir complex at Grave was determined through a Multicriteria Analyses and the calculation of the internal rat, Civil Engineering | Hydraulic Engineering

Innate lymphoid cells (ILCs) are abundant in mucosal tissues and involved in tissue homeostasis and barrier function. Although several ILC subsets have been identified, it is unknown if additional heterogeneity exists, and their differentiation pathways remain largely unclear. We applied mass cytometry to analyze ILCs in the human fetal intestine and distinguished 34 distinct clusters through a t-SNE-based analysis. A lineage (Lin)-CD7+CD127-CD45RO+CD56+ population clustered between the CD127+ ILC and natural killer (NK) cell subsets, and expressed diverse levels of Eomes, T-bet, GATA3, and RORγt. By visualizing the dynamics of the t-SNE computation, we identified smooth phenotypic transitions from cells within the Lin-CD7+CD127-CD45RO+CD56+ cluster to both the NK cells and CD127+ ILCs, revealing potential differentiation trajectories. In functional differentiation assays, the Lin-CD7+CD127-CD45RO+CD56+CD8a- cells could develop into CD45RA+ NK cells and CD127+RORγt+ ILC3-like cells. Thus, we identified a previously unknown intermediate innate subset that can differentiate into ILC3 and NK cells., Comp Graphics & Visualisation, Pattern Recognition and Bioinformatics