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Assigning behavioral functions to neural structures has long been a central goal in neuroscience and is a necessary first step toward a circuit-level understanding of how the brain generates behavior. Here, we map the neural substrates of locomotion and social behaviors for Drosophila melanogaster using automated machine-vision and machine-learning techniques. From videos of 400,000 flies, we quantified the behavioral effects of activating 2,204 genetically targeted populations of neurons. We combined a novel quantification of anatomy with our behavioral analysis to create brain-behavior correlation maps, which are shared as browsable web pages and interactive software. Based on these maps, we generated hypotheses of regions of the brain causally related to sensory processing, locomotor control, courtship, aggression, and sleep. Our maps directly specify genetic tools to target these regions, which we used to identify a small population of neurons with a role in the control of walking.

Assigning behavioral functions to neural structures has long been a central goal in neuroscience and is a necessary first step toward a circuit-level understanding of how the brain generates behavior. Here, we map the neural substrates of locomotion and social behaviors for Drosophila melanogaster using automated machine-vision and machine-learning techniques. From videos of 400,000 flies, we quantified the behavioral effects of activating 2,204 genetically targeted populations of neurons. We combined a novel quantification of anatomy with our behavioral analysis to create brain-behavior correlation maps, which are shared as browsable web pages and interactive software. Based on these maps, we generated hypotheses of regions of the brain causally related to sensory processing, locomotor control, courtship, aggression, and sleep. Our maps directly specify genetic tools to target these regions, which we used to identify a small population of neurons with a role in the control of walking.

Schizophrenic psychosis originates in traumatic relationships which disturb the ventromedial area of the frontal lobes during the first 18 months of life. These traumatic events realize the potential of the human genome and alter brain biochemistry; they provoke the failure of the ideal ego beginning with insula dysfunction, and they also alter the constitution of the self and of the ego ideal out of the psychotoxic relationships with the mother., La psicosis esquizofrénica tiene su origen en relaciones traumáticas que perturban el área ventromedial de los lóbulos frontales durante los primeros 18 meses de vida. Esos traumas actualizan el potencial del genoma humano y alteran la bioquímica cerebral; provocan el fracaso del yo ideal a partir de la disfunción de la ínsula y perturban la constitución del sí mismo y del ideal del yo a partir de las relaciones psicotóxicas con la madre.

Schizophrenia is a psychotic disorder which implies an autoerotic fíxation, the dissociation of body image, the failure of primary repression and the prevalence of the primary process over the secondary process. Given the extend m which the psychodynamic structure of schizophrenics associates with that of patients with bilateral orbitofrontal mjury, we can assert that the disturbance of this brain system during the pregenital development is at the origin of this psychosis., La esquizofrenia es un trastorno psicótico que implica una fijación autoerótica, la disociación de la imagen del cuerpo, el fracaso de la represión primaria y la prevalencia del proceso primario sobre el proceso secundario. En la medida en que la estructura psicodinámica de los esquizofrénicos se asocia con la de los pacientes con lesión orbitofrontal bilateral, podemos afirmar que la perturbación de este sistema cerebral durante el desarrollo pregenital está en el origen de esta psicosis.