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Uterine torsion is a common form of dystocia in cattle often associatedwith an oversized fetus. Cows are considered to be more susceptible to this condition than other domestic animals. On the basis of our current clinical practices, a novel retorsion method called “Ball rolling” has been developed to correct uterine torsion. In order to evaluate the effect of this new method, a total of 263 uterine torsion cases admitted to our animal hospital in the past 5 years were investigated, of which 79 cases were treated with the conventional rolling method and 184 cases were subjected to the “Ball rolling” method. In our “Ball rolling” method, the animals were immobilized by tying their forelegs, whereas their hind legs are left loosened, and are rolled like a ball towards the torsion direction to bring the uterus back into its physiological position. Then the clinical symptoms of the animals were recorded using basic physiological indicators, such as pulse, the degree of amniotic fluid choke rate and respiratory rate, pulse, and cervical injury bleeding. On the basis of the evaluation of the outcome, the parturient cows subjected to the “Ball rolling” method recovered faster with higher fetus survival rate., Torzija maternice čest je uzrok teškog teljenja krava, nerijetko povezan s prevelikim plodom. U krava su teški porođaji češći nego u drugih domaćih životinja. Na osnovi vlastite kliničke prakse razvijena je nova metoda retorzije nazvana „valjanje poput lopte“. Radi procjene učinka te nove metode ukupno su bila analizirana 263 slučaja torzije maternice bolnički obrađena u proteklih pet godina. Od toga je 79 slučajeva bilo obrađeno uobičajenom metodom valjanja, a 184 krave bile su podvrgnute novoj metodi „valjanja poput lopte“. U toj su metodi životinje bile imobilizirane vezanjem prednjih nogu dok su stražnje bile slobodne i valjane kao lopta prema smjeru torzije kako bi se maternica dovela u fiziološki položaj. Nakon toga klinički su znakovi bili procijenjeni na osnovi fizioloških pokazatelja kao što su: bilo, stupanj gušenja u amnionskoj tekućini, frekvencija disanja i krvarenje zbog ozljeda cerviksa. Na osnovi prosudbe ishoda, krave pri teljenju podvrgnute „valjanju“ oporavile su se brže i s većom stopom preživljavanja teladi.

This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg–1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg–1 bm) co-administration. Intravenous administration (10 and 25 mg kg–1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During co-administration, significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg–1 bm) and 2.1 % (250 mg kg–1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanol-kaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats.