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Ying Zhang,1 Tianfu Zhou,1 Jian Li,1 Nuo Xu,1 Mingze Cai,1 Hong Zhang,2 Qinfu Zhao,3 Siling Wang3 1Key Laboratory of TargetDrug Design and Research, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 2Van ’T Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, 1098 XH, the Netherlands; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of ChinaCorrespondence: Qinfu Zhao; Siling Wang Tel/Fax +86 24 43520555Email qinfuzhao@syphu.edu.cn; silingwang@syphu.edu.cnIntroduction: Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe3O4@mSiO2-Au/DOX was constructed.Methods: In vitro, the nanoplatform catalyzed NO’s release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine.Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au’s contribution from catalyzing NO release NO was 8.17%.Keywords: thermotherapy, chemotherapy, NO control release, magnetic mesoporous silica nanocomposites

Ying Zhang,1 Tianfu Zhou,1 Jian Li,1 Nuo Xu,1 Mingze Cai,1 Hong Zhang,2 Qinfu Zhao,3 Siling Wang3 1Key Laboratory of TargetDrug Design and Research, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 2Van ’T Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, 1098 XH, the Netherlands; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of ChinaCorrespondence: Qinfu Zhao; Siling Wang Tel/Fax +86 24 43520555Email qinfuzhao@syphu.edu.cn; silingwang@syphu.edu.cnIntroduction: Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe3O4@mSiO2-Au/DOX was constructed.Methods: In vitro, the nanoplatform catalyzed NO’s release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine.Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au’s contribution from catalyzing NO release NO was 8.17%.Keywords: thermotherapy, chemotherapy, NO control release, magnetic mesoporous silica nanocomposites

The structural, physical–chemical, and micromechanical characteristics of Al0.6Ti0.4N coatings deposited by different physical vapor deposition (PVD) methods, such as cathodic arc deposition (CAD), as well as advanced HiPIMS techniques were investigated in terms of their cutting performance during the machining of an Inconel 718 alloy. XRD studies had revealed that the HiPIMS coating featured lower residual stresses and more fine-grained structure. Electrochemical characterization with the potentiostat-impendence method shows that the HiPIMS coating has a significantly lower porosity than CAD. SEM and AFM studies of the surface morphology demonstrate that the HiPIMS coating has a smoother surface and an absence of droplet phases, in contrast with CAD. XRD, combined with FIB/TEM studies, shows a difference in the crystal structure of both coatings. The micromechanical characteristics of each coating, such as hardness, elastic modulus, fracture toughness, and adhesion to the substrate, were evaluated. The HiPIMS coating was found to possess a more beneficial combination of micromechanical properties compared to CAD. The beneficial characteristics of the HiPIMS coating alleviated the damage of the coated layer under operation. Combined with grain size refinement, this results in the improved adaptive performance of the HiPIMS coating through the formation of a greater amount of thermal barrier sapphire tribo-films on the friction surface. All of these characteristics contribute to the reduction of flank and crater wear intensity, as well as notching, leading to an improvement of the HiPIMS coating’s tool life.

Semisolid metal forming is becoming more and more attractive in the foundry industry due to its low cost and easy operation to produce high quality near-net-shape components. Over the past years, semisolid forming technique is mainly applied on the casting aluminum alloys due to their superior castability because of low melting temperature and viscosity. In semisolid forming field, thixoforming has been majorly used which involves of reheating the billet into semisolid state followed by casting process. Rheocasting is a more economic semisolid processing compared to thixoforming, which the semisolid billet is produced directly from liquid phase. The SEED process is one of reliable rheocasting techniques to produce high quality semisolid billets. To produce high quality semisolid billets, their unique rheological properties have been the most important issue need to be fully investigated. The aim of present project is to produce high quality semisolid AA7075 billets by SEED process and analyze their rheological properties under various process conditions. The effect of the SEED processing parameters and grain refiners on the semisolid microstructure and rheoformability were investigated. The deformation and rheological behavior of the semisolid billets of AA7075 base and its grain-refined alloys were studied using parallel-plate viscometer. In the first part, the evolution of liquid fraction to temperature of semisolid AA7075 alloy was investigated using Differential Scanning Calorimetry (DSC). It was found that the liquidus and solidus temperature of AA7075 alloy were 631℃ and 490℃ respectively. And the corresponding temperatures of solid fraction of 40% and 60% were 622℃ and 610℃, which was recognized as the temperature window for semisolid forming of this alloy. In the second part, the semisolid slurries were rheocasted using SEED technology and the effect of the SEED process parameters like swirling frequency and demolding temperature on evolution of microstructu

Ying Wang, Qinfu Zhao, Yanchen Hu, Lizhang Sun, Ling Bai, Tongying Jiang, Siling WangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Liaoning Province, People’s Republic of ChinaAbstract: The goal of the present study was to compare the drug release properties and stability of the nanoporous silica with different pore architectures as a matrix for improved delivery of poorly soluble drugs. For this purpose, three dimensional ordered macroporous (3DOM) silica with 3D continuous and interconnected macropores of different sizes (200 nm and 500 nm) and classic mesoporous silica (ie, Mobil Composition of Matter [MCM]-41 and Santa Barbara Amorphous [SBA]-15) with well-ordered two dimensional (2D) cylindrical mesopores were successfully fabricated and then loaded with the model drug indomethacin (IMC) via the solvent deposition method. Scanning electron microscopy (SEM), N2 adsorption, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were applied to systematically characterize all IMC-loaded nanoporous silica formulations, evidencing the successful inclusion of IMC into nanopores, the reduced crystallinity, and finally accelerated dissolution of IMC. It was worth mentioning that, in comparison to 2D mesoporous silica, 3DOM silica displayed a more rapid release profile, which may be ascribed to the 3D interconnected pore networks and the highly accessible surface areas. The results obtained from the stability test indicated that the amorphous state of IMC entrapped in the 2D mesoporous silica (SBA-15 and MCM-41) has a better physical stability than in that of 3DOM silica. Moreover, the dissolution rate and stability of IMC loaded in 3DOM silica was closely related to the pore size of macroporous silica. The colorimetric 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Cell Counting Kit (CCK)-8 assays in combination with direct morphology observations demonstrated the good biocompatibility of nanoporous sil

Ying Wang, Qinfu Zhao, Yanchen Hu, Lizhang Sun, Ling Bai, Tongying Jiang, Siling WangDepartment of Pharmaceutics, Shenyang Pharmaceutical University, Liaoning Province, People’s Republic of ChinaAbstract: The goal of the present study was to compare the drug release properties and stability of the nanoporous silica with different pore architectures as a matrix for improved delivery of poorly soluble drugs. For this purpose, three dimensional ordered macroporous (3DOM) silica with 3D continuous and interconnected macropores of different sizes (200 nm and 500 nm) and classic mesoporous silica (ie, Mobil Composition of Matter [MCM]-41 and Santa Barbara Amorphous [SBA]-15) with well-ordered two dimensional (2D) cylindrical mesopores were successfully fabricated and then loaded with the model drug indomethacin (IMC) via the solvent deposition method. Scanning electron microscopy (SEM), N2 adsorption, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were applied to systematically characterize all IMC-loaded nanoporous silica formulations, evidencing the successful inclusion of IMC into nanopores, the reduced crystallinity, and finally accelerated dissolution of IMC. It was worth mentioning that, in comparison to 2D mesoporous silica, 3DOM silica displayed a more rapid release profile, which may be ascribed to the 3D interconnected pore networks and the highly accessible surface areas. The results obtained from the stability test indicated that the amorphous state of IMC entrapped in the 2D mesoporous silica (SBA-15 and MCM-41) has a better physical stability than in that of 3DOM silica. Moreover, the dissolution rate and stability of IMC loaded in 3DOM silica was closely related to the pore size of macroporous silica. The colorimetric 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Cell Counting Kit (CCK)-8 assays in combination with direct morphology observations demonstrated the good biocompatibility of nanoporous sil