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BACKGROUND: Limited data exist on the clinical effectiveness of second-line (2L) vascular endothelial growth factor (receptor) targeted inhibitor (VEGF(R)i) sunitinib after first-line (1L) immuno-oncology (IO) therapy for patients with metastatic renal cell carcinoma (mRCC) in real-world settings. METHODS: A retrospective cohort study among adult patients with mRCC treated with 2L sunitinib following 1L IO was conducted from select International mRCC Database Consortium (IMDC) centers. All analyses were performed overall and by 1L ipilimumab + nivolumab (IPI+NIVO) or 1L IO+VEGF(R)i. Median overall survival (mOS) and time-to-treatment discontinuation (mTTD) in 2L were estimated using Kaplan-Meier analysis. The 2L objective response rate (ORR) (complete/partial response) was reported. RESULTS: Among 102 patients on 2L sunitinib, mean age was 61.3 years. IMDC risk scores at 2L initiation was available for 83 patients: 8 (9.6%) were favorable, 45 (54.2%) were intermediate, and 30 (36.1%) were poor risk. The 1L consisted of IPI+NIVO in 62 (60.8%), IO+VEGF(R)i therapy in 27 (26.5%), and IO monotherapy in 13 (12.7%) patients. Among all patients, mOS was 15.6 months (95% confidence interval [CI], 9.8-21.7), with a 1-year OS rate of 57.5% (95% CI, 45.2-68.0). mTTD was 5.4 months (95% CI, 4.2-7.2) and ORR was 22.5%. CONCLUSION: Despite availability of effective 1L therapies in recent years, 2L sunitinib continues to have clinical activity after failure of 1L IO. Further studies on optimal treatment sequencing after 1L IO progression are needed.

Recent studies have demonstrated the feasibility of carrier phase altimetry using reflected GNSS signals from the smooth surface, such as sea ice and inland water. Under grazing angle (GA) geometries, the conditions for coherent scattering are maximized, enabling carrier phase-delay altimetric techniques over more surface conditions. To validate the performance and explore the potential of spaceborne GNSS-R carrier phase altimetry at grazing angle, raw intermediate frequency (IF) data acquisitions from limb-looking antennas of Spire’s Cubesat constellation were collected to be geographically and temporarily collocated with ESA Sentinel 3A and 3B (S3A/B) passes. Altimetric measurements over different types of surfaces, including sea ice, lakes and open ocean have been extracted from these raw IF data, which are compared to collocated S3A/B radar altimeter measurements. The results of this activity will be presented.

Background: Treatment outcomes are poorly characterized in patients with metastatic chromophobe renal cell cancer (chrRCC), a subtype of renal cell carcinoma. Objective: This retrospective series aims to determine metastatic chrRCC treatment outcomes in the targeted therapy era. Methods: A retrospective data analysis was performed using the IMDC dataset of 4970 patients to determine metastatic chrRCC treatment outcomes in the targeted therapy era. Results: 109/4970 (2.2%) patients had metastatic chrRCC out of all patients with mRCC treated with targeted therapy. These patients were compared with 4861/4970 (97.8%) clear cell mRCC (ccRCC) patients. Patients with metastatic chrRCC had a similar OS compared to patients with ccRCC (23.8 months (95% CI 16.7 - 28.1) vs 22.4 months (95% CI 21.4 - 23.4), respectively (p = 0.0908). Patients with IMDC favorable (18%), intermediate (59%) and poor risk (23%) had median overall survivals of 31.4, 27.3, and 4.8 months, respectively (p = 0.028). Conclusions: To the authors' knowledge, this is the largest series of metastatic chrRCC patients and these results set new benchmarks for survival in clinical trial design and patient counseling. The IMDC criteria risk categories seem to stratify patients into appropriate favourable, intermediate, and poor risk groups, although larger patient numbers are required. It appears that outcomes between metastatic chrRCC and ccRCC are similar when treated with conventional targeted therapies. Patients with metastatic chrRCC can be treated with tyrosine kinase inhibitors and enrolled in clinical trials to further measure outcomes in this rare patient population.

Accepted: 2015-11-05, 著者人数: 23名

The most characteristic high-energy phenomena in the Galactic center (GC) region is the presence of strong K-shell emission lines from highly ionized Si, S, Ar, Ca, Fe and Ni, which form the Galactic Center X-ray Emission (GCXE). These multiple lines suggest that the GCXE is composed of at least two plasmas with temperatures of ~1 and ~7 keV. The GCXE also exhibits the K-shell lines from neutral Si, S, Ar, Ca, Fe and Ni atoms. A debatable issue is the origin of the GCXE plasma; whether it is a diffuse plasma or integrated emission of many unresolved point sources such as cataclysmic variables and active binaries. Detailed spectroscopy for these lines may provide a reliable picture of the GCXE plasma. The origin of the K-shell lines from neutral atoms is most likely the fluorescence by X-rays from a putative past flare of Sgr A*. Therefore ASTRO-H may provide unprecedented data for the past light curve of Sgr A*. All these lines may provide key information for the dynamics of the GCXE, using possible Doppler shift and/or line broadening. This paper overviews these line features and the previous interpretation of their origin. We propose extended or revised science with the ASTRO-H observations of some select objects in the GC region., Comment: 19 pages, 13 figures, ASTRO-H White Paper

As the endpoints of massive star evolution, neutron stars are enigmatic celestial objects characterized by extremely dense and exotic nuclear matter, magnetospheres with positrons (antimatter), rapid rotation and ultra-strong magnetic fields. Such an extreme environment has provided an accessible astrophysical laboratory to study physics under conditions unattainable on Earth and to tackle a range of fundamental questions related to: the aftermath of stellar evolution and the powerful explosions of massive stars, the equation of state and physics of some of the most exotic and magnetic stars in the Universe, the workings of the most powerful particle accelerators in our Galaxy and beyond, and the sources of gravitational waves that are yet to be detected. Recent observations revealed a great diversity of neutron stars, including ultra-strongly magnetized pulsars, referred to as "magnetars", and unusual types of accreting X-ray pulsars. In this white paper, we highlight the prospects of the upcoming X-ray mission, ASTRO-H, in studying these highly magnetized neutron stars., Comment: 40 pages, 28 figures, ASTRO-H White Paper

Interacting binaries in which a white dwarf accretes material from a companion --- cataclysmic variables (CVs) in which the mass loss is via Roche-lobe overflow, and symbiotic stars in which the white dwarf captures the wind of a late type giant --- are relatively commonplace. They display a wide range of behaviors in the optical, X-rays, and other wavelengths, which still often baffles observers and theorists alike. They are likely to be a significant contributor to the Galactic ridge X-ray emission, and the possibility that some CVs or symbiotic stars may be the progenitors of some of the Type Ia supernovae deserves serious consideration. Furthermore, these binaries serve as excellent laboratories in which to study physics of X-ray emission from high density plasma, accretion physics, reflection, and particle acceleration. ASTRO-H is well-matched to the study of X-ray emission from many of these objects. In particular, the excellent spectral resolution of the SXS will enable dynamical studies of the X-ray emitting plasma. We also discuss the possibility of identifying an accreting, near-Chandrasekhar-mass white dwarf by measuring the gravitational redshift of the 6.4 keV line., Comment: 25 pages, 20 figures, ASTRO-H White Paper

The most characteristic high-energy phenomena in the Galactic center (GC) region is the presence of strong K-shell emission lines from highly ionized Si, S, Ar, Ca, Fe and Ni, which form the Galactic Center X-ray Emission (GCXE). These multiple lines suggest that the GCXE is composed of at least two plasmas with temperatures of ~1 and ~7 keV. The GCXE also exhibits the K-shell lines from neutral Si, S, Ar, Ca, Fe and Ni atoms. A debatable issue is the origin of the GCXE plasma; whether it is a diffuse plasma or integrated emission of many unresolved point sources such as cataclysmic variables and active binaries. Detailed spectroscopy for these lines may provide a reliable picture of the GCXE plasma. The origin of the K-shell lines from neutral atoms is most likely the fluorescence by X-rays from a putative past flare of Sgr A*. Therefore ASTRO-H may provide unprecedented data for the past light curve of Sgr A*. All these lines may provide key information for the dynamics of the GCXE, using possible Doppler shift and/or line broadening. This paper overviews these line features and the previous interpretation of their origin. We propose extended or revised science with the ASTRO-H observations of some select objects in the GC region., Comment: 19 pages, 13 figures, ASTRO-H White Paper

Interacting binaries in which a white dwarf accretes material from a companion --- cataclysmic variables (CVs) in which the mass loss is via Roche-lobe overflow, and symbiotic stars in which the white dwarf captures the wind of a late type giant --- are relatively commonplace. They display a wide range of behaviors in the optical, X-rays, and other wavelengths, which still often baffles observers and theorists alike. They are likely to be a significant contributor to the Galactic ridge X-ray emission, and the possibility that some CVs or symbiotic stars may be the progenitors of some of the Type Ia supernovae deserves serious consideration. Furthermore, these binaries serve as excellent laboratories in which to study physics of X-ray emission from high density plasma, accretion physics, reflection, and particle acceleration. ASTRO-H is well-matched to the study of X-ray emission from many of these objects. In particular, the excellent spectral resolution of the SXS will enable dynamical studies of the X-ray emitting plasma. We also discuss the possibility of identifying an accreting, near-Chandrasekhar-mass white dwarf by measuring the gravitational redshift of the 6.4 keV line., Comment: 25 pages, 20 figures, ASTRO-H White Paper

As the endpoints of massive star evolution, neutron stars are enigmatic celestial objects characterized by extremely dense and exotic nuclear matter, magnetospheres with positrons (antimatter), rapid rotation and ultra-strong magnetic fields. Such an extreme environment has provided an accessible astrophysical laboratory to study physics under conditions unattainable on Earth and to tackle a range of fundamental questions related to: the aftermath of stellar evolution and the powerful explosions of massive stars, the equation of state and physics of some of the most exotic and magnetic stars in the Universe, the workings of the most powerful particle accelerators in our Galaxy and beyond, and the sources of gravitational waves that are yet to be detected. Recent observations revealed a great diversity of neutron stars, including ultra-strongly magnetized pulsars, referred to as "magnetars", and unusual types of accreting X-ray pulsars. In this white paper, we highlight the prospects of the upcoming X-ray mission, ASTRO-H, in studying these highly magnetized neutron stars., Comment: 40 pages, 28 figures, ASTRO-H White Paper

We report the first observation of 3$-$30 MeV prolonged gamma-ray emission that was abruptly terminated by lightning. The gamma-ray detection was made during winter thunderstorms on December 30, 2010 by the Gamma-Ray Observation of Winter THunderclouds (GROWTH) experiment carried out in a coastal area along the Sea of Japan. The gamma-ray flux lasted for less than 3 min, continuously hardening closer to the lightning occurrence. The hardening at energies of 3$-$10 MeV energies was most prominent. The gamma-ray flux abruptly ceased less than 800 ms before the lightning flash that occurred over 5 km away from the experimental site. In addition, we observed a clear difference in the duration of the 3$-$10 MeV gamma rays and those $>$10 MeV, suggesting that the area of $>$10 MeV gamma-ray emission is considerably smaller than that of the lower-energy gamma rays. This work may give a manifestation that a local region emitting prolonged gamma rays connects with a distant region to initiate lightning., Comment: Accepted for publication in Phys. Rev. Lett.; 14 pages, 4 figures

We report the first observation of 3$-$30 MeV prolonged gamma-ray emission that was abruptly terminated by lightning. The gamma-ray detection was made during winter thunderstorms on December 30, 2010 by the Gamma-Ray Observation of Winter THunderclouds (GROWTH) experiment carried out in a coastal area along the Sea of Japan. The gamma-ray flux lasted for less than 3 min, continuously hardening closer to the lightning occurrence. The hardening at energies of 3$-$10 MeV energies was most prominent. The gamma-ray flux abruptly ceased less than 800 ms before the lightning flash that occurred over 5 km away from the experimental site. In addition, we observed a clear difference in the duration of the 3$-$10 MeV gamma rays and those $>$10 MeV, suggesting that the area of $>$10 MeV gamma-ray emission is considerably smaller than that of the lower-energy gamma rays. This work may give a manifestation that a local region emitting prolonged gamma rays connects with a distant region to initiate lightning., Comment: Accepted for publication in Phys. Rev. Lett.; 14 pages, 4 figures

Centaurus B is a nearby radio galaxy positioned in the Southern hemisphere close to the Galactic plane. Here we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the gamma-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies, and analyze the extension and variability of the gamma-ray source in the LAT dataset, in which it appears as a steady gamma-ray emitter. The X-ray core of Centaurus B is detected as a bright source of a continuum radiation. We do not detect however any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and gamma-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed gamma-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed gamma-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. By means of synchrotron self-Compton modeling we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum., Comment: Accepted for publication in A&A. 11 pages

Centaurus B is a nearby radio galaxy positioned in the Southern hemisphere close to the Galactic plane. Here we present a detailed analysis of about 43 months of accumulated Fermi-LAT data of the gamma-ray counterpart of the source initially reported in the 2nd Fermi-LAT catalog, and of newly acquired Suzaku X-ray data. We confirm its detection at GeV photon energies, and analyze the extension and variability of the gamma-ray source in the LAT dataset, in which it appears as a steady gamma-ray emitter. The X-ray core of Centaurus B is detected as a bright source of a continuum radiation. We do not detect however any diffuse X-ray emission from the known radio lobes, with the provided upper limit only marginally consistent with the previously claimed ASCA flux. Two scenarios that connect the X-ray and gamma-ray properties are considered. In the first one, we assume that the diffuse non-thermal X-ray emission component is not significantly below the derived Suzaku upper limit. In this case, modeling the inverse-Compton emission shows that the observed gamma-ray flux of the source may in principle be produced within the lobes. This association would imply that efficient in-situ acceleration of the radiating electrons is occurring and that the lobes are dominated by the pressure from the relativistic particles. In the second scenario, with the diffuse X-ray emission well below the Suzaku upper limits, the lobes in the system are instead dominated by the magnetic pressure. In this case, the observed gamma-ray flux is not likely to be produced within the lobes, but instead within the nuclear parts of the jet. By means of synchrotron self-Compton modeling we show that this possibility could be consistent with the broad-band data collected for the unresolved core of Centaurus B, including the newly derived Suzaku spectrum., Comment: Accepted for publication in A&A. 11 pages

The Gamma-Ray Observation of Winter THunderclouds (GROWTH) experiment, consisting of two radiation-detection subsystems, has been operating since 2006 on the premises of Kashiwazaki-Kariwa nuclear power plant located at the coastal area of Japan Sea. By 2010 February, GROWTH detected 7 long-duration $\gamma$-rays emissions associated with winter thunderstorms. Of them, two events, obtained on 2007 December 13 and 2008 December 25, are reported.On both occasions, all inorganic scintillators (NaI, CsI, and BGO) of the two subsystems detected significant gamma-ray signals lasting for >1 minute. Neither of these two events were associated with any lightning. In both cases, the gamma-ray energy spectra extend to 10 MeV, suggesting that the detected gamma-rays are produced by relativistic electrons via bremsstrahlung. Assuming that the initial photon spectrum at the source is expressed by a power-law function,the observed photons can be interpreted as being radiated from a source located at a distance of 290-560 m for the 2007 event and 110-690 m for the 2008 one, both at 90% confidence level.Employing these photon spectra, the number of relativistic electrons is estimated as 10^9 - 10^{11}. The estimation generally agrees with those calculated based on the relativistic runaway electron avalanche model. A GROWTH photon spectrum, summed over 3 individual events including the present two events and another reported previously, has similar features including a cut-off energy, to an averaged spectrum of terrestrial gamma-ray flashes., Comment: 46 pages, 13 figures, accepted for publication in JGR-Atmosphere

The Gamma-Ray Observation of Winter THunderclouds (GROWTH) experiment, consisting of two radiation-detection subsystems, has been operating since 2006 on the premises of Kashiwazaki-Kariwa nuclear power plant located at the coastal area of Japan Sea. By 2010 February, GROWTH detected 7 long-duration $\gamma$-rays emissions associated with winter thunderstorms. Of them, two events, obtained on 2007 December 13 and 2008 December 25, are reported.On both occasions, all inorganic scintillators (NaI, CsI, and BGO) of the two subsystems detected significant gamma-ray signals lasting for >1 minute. Neither of these two events were associated with any lightning. In both cases, the gamma-ray energy spectra extend to 10 MeV, suggesting that the detected gamma-rays are produced by relativistic electrons via bremsstrahlung. Assuming that the initial photon spectrum at the source is expressed by a power-law function,the observed photons can be interpreted as being radiated from a source located at a distance of 290-560 m for the 2007 event and 110-690 m for the 2008 one, both at 90% confidence level.Employing these photon spectra, the number of relativistic electrons is estimated as 10^9 - 10^{11}. The estimation generally agrees with those calculated based on the relativistic runaway electron avalanche model. A GROWTH photon spectrum, summed over 3 individual events including the present two events and another reported previously, has similar features including a cut-off energy, to an averaged spectrum of terrestrial gamma-ray flashes., Comment: 46 pages, 13 figures, accepted for publication in JGR-Atmosphere

The Polarized Gamma-ray Observer, PoGOLite, is a balloon experiment with the capability of detecting 10% polarization from a 200 mCrab celestial object in the energy-range 25–80 keV. During a beam test at KEK-PF in 2008, 19 detector units and one anti-coincidence detector were assembled, and a 50 keV X-ray beam with a polarization degree of ∼90% was irradiated at the center unit. Signals from all 20 units were fed into flight-version electronics consisting of six circuit boards (four waveform digitizer boards, one digital I/O board and one router board) and one microprocessor (SpaceCube), which communicate using a SpaceWire interface. One digitizer board, which can associate up to 8 detectors, outputs a trigger signal. The digital I/O board handles the trigger and returns a data acquisition request if there is no veto signal (upper or pulse-shape discriminators) from any detector unit. This data acquisition system worked well, and the modulation factor was successfully measured to be ∼34%. These results confirmed the capabilities of the data-acquisition system for a “pathfinder” flight planned in 2010., QC 20120424

During thunderstorms on 2008 September 20, a simultaneous detection of gamma rays and electrons was made at a mountain observatory in Japan located 2770 m above sea level. Both emissions, lasting 90 seconds, were associated with thunderclouds rather than lightning. The photon spectrum, extending to 10 MeV, can be interpreted as consisting of bremsstrahlung gamma rays arriving from a source which is 60 - 130 m in distance at 90% confidence level. The observed electrons are likely to be dominated by a primary population escaping from an acceleration region in the clouds., Comment: 12 pages, 3 figures, accepted for publication in Physical Review Letters

The Polarized Gamma-ray Observer, PoGOLite, is a balloon experiment with the capability of detecting 10% polarization from a 200 mCrab celestial object in the energy range 25 #x2013;80 keV. During a beam test at KEK-PF in February 2008, 20 detector units were assembled, and a 50 keV X-ray beam with a polarization degree of #x223C;90% was irradiated at the center unit. Signals from all 20 units were fed into flightversion electronics consisting of six circuit boards (four waveform digitizer boards, one digital I/O board and one router board) and one microprocessor (SpaceCube), which communicate using a SpaceWire interface. One digitizer board, which can associate up to 8 PDCs, outputs a trigger signal. The digital I/O board handles the trigger and returns a data acquisition request if there is no veto signal (upper or pulse-shape discriminators) from any detector unit. This data acquisition system worked well, and the modulation factor was successfully measured to be #x223C;34%. These results confirmed the capabilities of both detector and data-acquisition system for a pathfinder flight planned in 2010., QC 20120210

The broad-band 1-300 keV Suzaku spectrum of IGR J17497-2821, the X-ray transient discovered by INTEGRAL in September 2006, is presented. Suzaku observed IGR J17497-2821 on September 25, eight days after its discovery, for a net exposure of about 53 ksec. During the Suzaku observation, IGR J17497-2821 is very bright, 2 x 10^37 erg/s at 8 kpc in the 1-300 keV range, and shows a hard spectrum, typical of black hole candidates in the low-hard state. Despite the multi-mission X-ray monitoring of the source, only with Suzaku is it possible to obtain a broad-band spectrum in the 1-300 keV range with a very high signal to noise ratio. A sum of a multi-color disc (DISKBB) and a thermal Comptonization component (COMPPS) with mild reflection is a good representation of our IGR J17497-2821 Suzaku spectrum. The spectral properties of the accretion disc as well as the cut-off energy in the spectrum at about 150 keV are clearly detected and constrained. We discuss the implications on the physical model used to interpret the data and the comparison with previous results., Comment: 7 pages, 6 figures, Accepted for publication in PASJ, Suzaku Special Issue

The broad-band 1-300 keV Suzaku spectrum of IGR J17497-2821, the X-ray transient discovered by INTEGRAL in September 2006, is presented. Suzaku observed IGR J17497-2821 on September 25, eight days after its discovery, for a net exposure of about 53 ksec. During the Suzaku observation, IGR J17497-2821 is very bright, 2 x 10^37 erg/s at 8 kpc in the 1-300 keV range, and shows a hard spectrum, typical of black hole candidates in the low-hard state. Despite the multi-mission X-ray monitoring of the source, only with Suzaku is it possible to obtain a broad-band spectrum in the 1-300 keV range with a very high signal to noise ratio. A sum of a multi-color disc (DISKBB) and a thermal Comptonization component (COMPPS) with mild reflection is a good representation of our IGR J17497-2821 Suzaku spectrum. The spectral properties of the accretion disc as well as the cut-off energy in the spectrum at about 150 keV are clearly detected and constrained. We discuss the implications on the physical model used to interpret the data and the comparison with previous results., Comment: 7 pages, 6 figures, Accepted for publication in PASJ, Suzaku Special Issue

The PoGOLite is a new balloon-borne instrument to measure the polarization of hard X-rays / soft gamma-rays in the 25-80 keV energy range for the first time. In order to detect the polarization, PoGOLite measures the azimuthal angle asymmetry of Compton scattering and the subsequent photo- absorption in an array of detectors. This array consists of 217 well-type phoswich detector cells (PDCs) surrounded by a side anti-coincidence shield (SAS) composed of 54 segments of BGO crystals. At balloon altitude, the intensity of backgrounds due to cosmic-ray charged particles, atmospheric gamma-rays and neutrons is extremely high, typically a few hundred Hz per unit. Hence the data acquisition (DAQ) system of PoGOLite is required to handle more than 270 signals simultaneously, and detect weak signals from astrophysical objects (lOOmCrab, 1.5 cs-1 in 25-80 keV ) under such a severe environment. We have developed a new DAQ system consisting of front-end electronics, waveform digitizer, field programmable gate array (FPGA) and a microprocessor. In this system, all output signals of PDC / SAS are fed into individual charge-sensitive amplifier and then digitized to 12 bit accuracy at 24MSa/s by pipelined analog to digital converters. A DAQ board for the PDC records waveforms which will be examined in an off-line analysis to distinguish signals from the background events and measure the energy spectrum and polarization of targets. A board for the SAS records hit pattern to be used for background rejection. It also continuously records a pulse-height analysis (PHA) histogram to monitor incident background flux. These basic functions of the DAQ system were verified in a series of beam tests., QC 20120228

Polarized gamma-rays are expected from a wide variety of sources including rotationpowered pulsars, accreting black holes and neutron stars, and jet-dominated active galaxies. Polarization measurements provide a powerful probe of the gamma-ray emission mechanism and the distribution of magnetic and radiation fields around the source. No measurements have been performed in the soft gamma-ray band where non-thermal processes are expected to produce high degrees of polarization. The PoGOLite experiment applies well-type phoswich detector technology to polarization measurements in the 25 - 80 keV energy range. The instrument uses Compton scattering and photoabsorption in an array of 217 phoswich detector cells made of plastic and BGO scintillators, and surrounded by active BGO shields. A prototype of the flight instrument has been tested with polarized gammarays and background generated with radioactive sources. The test results and computer simulations confirm that the instrument can detect 10% polarization of a 200 mCrab source in one 6 hour balloon observation. In flight, targets are constrained to within better than 5% of the field-of-view (~5 degrees squared) in order to maximize the effective detection area during observations. The pointing direction on the sky is determined by an attitude control system comprising star trackers, differential GPS receiver system, gyroscopes, accelerometers and magnetometers which provide correction signals to a reaction wheel and torque motor system. Additionally, the entire polarimeter assembly rotates around its viewing axis to minimize systematic bias during observations. Flights are foreseen to start in 2009- 2010 and will target northern sky sources including the Crab pulsar/nebula, Cygnus X-1, and Hercules X-1. These observations will provide valuable information about the pulsar emission mechanism, the geometry around the black hole, and photon transportation in the strongly magnetized neutron star surface, respectively. Fu, QC 20150415

A report is made on a comprehensive observation of a burst-like $\gamma$-ray emission from thunderclouds on the Sea of Japan, during strong thunderstorms on 2007 January 6. The detected emission, lasting for $\sim$40 seconds, preceded cloud-to-ground lightning discharges. The burst spectrum, extending to 10 MeV, can be interpreted as consisting of bremsstrahlung photons originating from relativistic electrons. This ground-based observation provides first clear evidence that strong electric fields in thunderclouds can continuously accelerate electrons beyond 10 MeV prior to lightning discharges., Comment: 12 pages, 4 figures, accepted for publication in Physical Review Letters

The PoGOLite is a new balloon-borne instrument to measure the polarization of hard X-rays/soft gamma-rays in the 25-80 keV energy range for the first time. In order to detect the polarization, PoGOLite measures the azimuthal angle asymmetry of Compton scattering and the subsequent photo-absorption in an array of detectors. This array consists of 217 well-type phoswich detector cells (PDCs) surrounded by a side anti-coincidence shield (SAS) composed of 54 segments of BGO crystals. At balloon altitude, the intensity of backgrounds due to cosmic-ray charged particles, atmospheric gamma-rays and neutrons is extremely high, typically a few hundred Hz per unit. Hence the data acquisition (DAQ) system of PoGOLite is required to handle more than 270 signals simultaneously, and detect weak signals from astrophysical objects (100mCrab, 1.5 cs(-1) in 25-80 keV) under such a severe environment. We have developed a new DAQ system consisting of front-end electronics, waveform digitizer, Field Programmable Gate Array (FPGA) and a microprocessor. In this system, all output signals of PDC / SAS are fed into individual charge-sensitive amplifier and then digitized to 12 bit accuracy at 24 MSa/s by pipelined analog to digital converters. A DAQ board for the PDC records waveforms which will be examined in an off-line analysis to distinguish signals from the background events and measure the energy spectrum and polarization of targets. A board for the SAS records hit pattern to be used for background rejection. It also continuously records a pulse-height analysis (PHA) histogram to monitor incident background flux. These basic functions of the DAQ system were verified in a series of beam tests., Tanaka, T. Arimoto, M. Axelsson, M. Bjornsson, C.-I. Bogaert, G. Carlson, P. Cooney, M. Craig, W. Engdegard, O. Fukazawa, Y. Gunji, S. Hjalmarsdotter, L. Kamae, T. Kanai, Y. Kataoka, J. Katsuta, J. Kawai, N. Kazejev, J. Kiss, M. Klamra, W. Larsson, S. Madejski, G. Bettolo, C. Marini Mizuno, T. Ng, J. Nomachi, M. Odaka, H. Pearce, M. Ruckman, L. Ryde, F. Tajima, H. Takahashi, H. Takahashi, T. Thurston, T. Ueno, M. Varner, G. Ylinen, T. Yoshida, H. Yuasa, T. IEEE Nuclear Science Symposium/Medical Imaging Conference OCT 26-NOV 03, 2007 Honolulu, HI

The in-orbit performance and calibration of the Hard X-ray Detector (HXD) on board the X-ray astronomy satellite Suzaku are described. Its basic performances, including a wide energy bandpass of 10-600 keV, energy resolutions of ~4 keV (FWHM) at 40 keV and ~11% at 511 keV, and a high background rejection efficiency, have been confirmed by extensive in-orbit calibrations. The long-term gains of PIN-Si diodes have been stable within 1% for half a year, and those of scintillators have decreased by 5-20%. The residual non-X-ray background of the HXD is the lowest among past non-imaging hard X-ray instruments in energy ranges of 15-70 and 150-500 keV. We provide accurate calibrations of energy responses, angular responses, timing accuracy of the HXD, and relative normalizations to the X-ray CCD cameras using multiple observations of the Crab Nebula., Comment: 45 pages, 40 figures and 9 tables; accepted for Pulications of the Astronomical Society of Japan

The in-orbit performance and calibration of the Hard X-ray Detector (HXD) on board the X-ray astronomy satellite Suzaku are described. Its basic performances, including a wide energy bandpass of 10-600 keV, energy resolutions of ~4 keV (FWHM) at 40 keV and ~11% at 511 keV, and a high background rejection efficiency, have been confirmed by extensive in-orbit calibrations. The long-term gains of PIN-Si diodes have been stable within 1% for half a year, and those of scintillators have decreased by 5-20%. The residual non-X-ray background of the HXD is the lowest among past non-imaging hard X-ray instruments in energy ranges of 15-70 and 150-500 keV. We provide accurate calibrations of energy responses, angular responses, timing accuracy of the HXD, and relative normalizations to the X-ray CCD cameras using multiple observations of the Crab Nebula., Comment: 45 pages, 40 figures and 9 tables; accepted for Pulications of the Astronomical Society of Japan

BACKGROUND: In failing hearts, homeostatic mechanisms contrive to maximize stroke work and maintain normal arterial blood pressure at the expense of energetic efficiency. In contrast dobutamine reestablishes maximal mechanical efficiency by promoting energetically optimal loading conditions. However, dobutamine also wastefully increases nonmechanical oxygen consumption. We investigated whether direct mechanical cardiac compression would reestablish maximal mechanical efficiency without the oxygen-wasting effect. METHODS: The pressure-volume relationship and myocardial oxygen consumption were derived in sheep using left ventricular pressure and volume from manometer-tipped and conductance catheters, and coronary flow from Transonics flow probe. RESULTS: Propranolol hydrochloride and atropine sulfate were administered to reduce ejection fraction to 21% when ventricular elastance fell to 1.35 mm Hg/mL and mechanical efficiency to 79% of maximal. Low-pressure direct mechanical compression of the failing heart restored mechanical efficiency to 94% of maximal and realigned optimal left ventricular end-systolic pressure with operating left ventricular end-systolic pressure without altering nonmechanical oxygen consumption. CONCLUSIONS: We conclude that direct cardiac compression restores mechanical efficiency to normal maximum without wasting energy on additional nonmechanical activity.

BACKGROUND: In failing hearts, homeostatic mechanisms contrive to maximize stroke work and maintain normal arterial blood pressure at the expense of energetic efficiency. In contrast dobutamine reestablishes maximal mechanical efficiency by promoting energetically optimal loading conditions. However, dobutamine also wastefully increases nonmechanical oxygen consumption. We investigated whether direct mechanical cardiac compression would reestablish maximal mechanical efficiency without the oxygen-wasting effect. METHODS: The pressure-volume relationship and myocardial oxygen consumption were derived in sheep using left ventricular pressure and volume from manometer-tipped and conductance catheters, and coronary flow from Transonics flow probe. RESULTS: Propranolol hydrochloride and atropine sulfate were administered to reduce ejection fraction to 21% when ventricular elastance fell to 1.35 mm Hg/mL and mechanical efficiency to 79% of maximal. Low-pressure direct mechanical compression of the failing heart restored mechanical efficiency to 94% of maximal and realigned optimal left ventricular end-systolic pressure with operating left ventricular end-systolic pressure without altering nonmechanical oxygen consumption. CONCLUSIONS: We conclude that direct cardiac compression restores mechanical efficiency to normal maximum without wasting energy on additional nonmechanical activity.

In the transmission CT imaging system with scintillator-CCD detector using synchrotron monochromatic x-ray as sheet beam, improvement of reconstructed image quality is investigated, The properties of experimental facilities cause the incident beam intensity to be spatially inhomogeneous, and to temporally attenuate, In order to achieve more reliable reconstruction, we propose the data-correction and estimation method based on the properties of the facilities and the principle of CT reconstruction, and confirm its effectiveness using a physical phantom., Papers from the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 25-28, 2001, Istanbul, Turkey. See also ADM001351 for entire conference on cd-rom.

The infrasound induced by a series of blasting patterns was measured in the Ube-Isa limestone mine face, Japan, and at a house in a neighbouring village as well as the window vibration at the house. The results showed that a longer delay time of the blasting caps was necessary to reduce the lower-frequency component causing a large vibration and that a shorter delay time was required to shorten the duration of blasting and reduce the resonant vibration. In tests conducted using different delay times of the blasting caps, the window vibration was reduced by 60% in total energy and by 24% in maximum displacement, compared with the minimum vibration of normal blasting using a fixed blasting-cap delay time., The infrasound induced by a series of blasting patterns was measured in the Ube-Isa limestone mine face, Japan, and at a house in a neighbouring village as well as the window vibration at the house. The results showed that a longer delay time of the blasting caps was necessary to reduce the lower-frequency component causing a large vibration and that a shorter delay time was required to shorten the duration of blasting and reduce the resonant vibration. In tests conducted using different delay times of the blasting caps, the window vibration was reduced by 60% in total energy and by 24% in maximum displacement, compared with the minimum vibration of normal blasting using a fixed blasting-cap delay time.