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Your search keyword '"Yip, Tsz Chun"' showing total 10 results
Start Over Author "Yip, Tsz Chun" Publication Type Electronic Resources
10 results on '"Yip, Tsz Chun"'

1. Synthesis of the C17-C30 Bis-THF Fragment of Iriomoteolide-13a via Intramolecular syn -Oxypalladation of 26-Ene-17,21,23,28-tetraol

Author

Gao, Kai, Ma, Haichen, Yip, Tsz Chun, Zhao, Hui, Dai, Wei Min, Gao, Kai, Ma, Haichen, Yip, Tsz Chun, Zhao, Hui, and Dai, Wei Min

Abstract

The fully substituted C17-C30 bis-tetrahydrofuran fragment of the proposed structure of iriomoteolide-13a has been assembled via asymmetric dihydroxylation-S(N)2 cyclization of 19-mesyloxy-21ene-26-yne and PdCl2-catalyzed syn-oxypalladation of 26-ene17,21,23,28-tetraol as the key steps. The syn-oxypalladation process gave an 89:11 diastereoselectivity and tolerated the free poly-hydroxy groups in the highly functionalized substrate.

Published
2023

2. Synthesis of the Macrolactone Cores of Maltepolides via a Diene-Ene Ring-Closing Metathesis Strategy

Author

Sit, Man Ki, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Eric, Zhang, Wen, Dai, Wei-Min, Sit, Man Ki, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Eric, Zhang, Wen, and Dai, Wei-Min

Abstract

Synthesis of the C19-truncated maltepolide E has been accomplished via a diene-ene ring-closing metathesis (RCM) strategy without damage to the C11-C14 alkenyl epoxy unit. Upon release of the C17-OH group, it attacked at the C14 position with double bond migration and epoxide ring opening to furnish the C19-truncated maltepolides A and B as proposed for the biosynthesis of maltepolides.

Published
2023

3. Synthesis of the Macrolactone Cores of Maltepolides via a Diene–Ene Ring-Closing Metathesis Strategy

Author

Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, Dai, Wei Min, Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, and Dai, Wei Min

Abstract

Synthesis of the C19-truncated maltepolide E has been accomplished via a diene–ene RCM strategy without damage to the C11–C14 alkenyl epoxy unit. Upon release of the C17-OH group, it attacked at the C14 position with double bond migration and epoxide ring-opening to furnish the C19-truncated maltepolide A and B as proposed for the biosynthesis of maltepolides. Preliminary cytotoxicity data of the synthesized C19-truncated maltepolides against L929 mouse fibroblast cell line suggest irrelevance of the vinyl epoxide and importance of the conjugated dienyl keto unit for the observed anticancer activity.

Published
2021

4. Synthesis of the Macrolactone Cores of Maltepolides via a Diene–Ene Ring-Closing Metathesis Strategy

Author

Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, Dai, Wei Min, Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, and Dai, Wei Min

Abstract

Synthesis of the C19-truncated maltepolide E has been accomplished via a diene–ene RCM strategy without damage to the C11–C14 alkenyl epoxy unit. Upon release of the C17-OH group, it attacked at the C14 position with double bond migration and epoxide ring-opening to furnish the C19-truncated maltepolide A and B as proposed for the biosynthesis of maltepolides. Preliminary cytotoxicity data of the synthesized C19-truncated maltepolides against L929 mouse fibroblast cell line suggest irrelevance of the vinyl epoxide and importance of the conjugated dienyl keto unit for the observed anticancer activity.

Published
2021

5. Synthesis of the Macrolactone Cores of Maltepolides via a Diene–Ene Ring-Closing Metathesis Strategy

Author

Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, Dai, Wei Min, Man, Ki Sit, Cao, Hui Hui, Wu, Yandong, Yip, Tsz Chun, Bendel, Lars Erik, Zhang, Wen, and Dai, Wei Min

Abstract

Synthesis of the C19-truncated maltepolide E has been accomplished via a diene–ene RCM strategy without damage to the C11–C14 alkenyl epoxy unit. Upon release of the C17-OH group, it attacked at the C14 position with double bond migration and epoxide ring-opening to furnish the C19-truncated maltepolide A and B as proposed for the biosynthesis of maltepolides. Preliminary cytotoxicity data of the synthesized C19-truncated maltepolides against L929 mouse fibroblast cell line suggest irrelevance of the vinyl epoxide and importance of the conjugated dienyl keto unit for the observed anticancer activity.

Published
2021

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