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In creating the 2020 and 2013 edition of the AVMA Guidelines for the Euthanasia of Animals (Guidelines), the POE made every effort to identify and apply the best research and empirical information available. As new research is conducted and more practical experience gained, recommended methods of euthanasia may change. As such, the AVMA and its POE have made a commitment to ensure the Guidelines reflect an expectation and paradigm of continuous improvement that is consistent with the obligations of the Veterinarian’s Oath. The Guidelines set criteria for euthanasia, specify appropriate euthanasia methods and agents, and are intended to assist veterinarians in their exercise of professional judgment. The Guidelines acknowledge that euthanasia is a process involving more than just what happens to an animal at the time of its death. Apart from delineating appropriate methods and agents, these Guidelines also recognize the importance of considering and applying appropriate pre-euthanasia (eg, sedation) and animal handling practices, as well as attention to disposal of animals’ remains.