1. Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids.
- Author
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Jin, Haibao, Jin, Haibao, Ding, Yan-Huai, Wang, Mingming, Song, Yang, Liao, Zhihao, Newcomb, Christina J, Wu, Xuepeng, Tang, Xian-Qiong, Li, Zheng, Lin, Yuehe, Yan, Feng, Jian, Tengyue, Mu, Peng, Chen, Chun-Long, Jin, Haibao, Jin, Haibao, Ding, Yan-Huai, Wang, Mingming, Song, Yang, Liao, Zhihao, Newcomb, Christina J, Wu, Xuepeng, Tang, Xian-Qiong, Li, Zheng, Lin, Yuehe, Yan, Feng, Jian, Tengyue, Mu, Peng, and Chen, Chun-Long
- Abstract
Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique "rolling-up and closure of nanosheet" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes. These nanotubes undergo a pH-triggered, reversible contraction-expansion motion. By varying the number of hydrophobic residues of peptoids, we demonstrate tuning of nanotube wall thickness, diameter, and mechanical properties. Atomic force microscopy-based mechanical measurements show peptoid nanotubes are highly stiff (Young's Modulus ~13-17 GPa). We further demonstrate the precise incorporation of functional groups within nanotubes and their applications in water decontamination and cellular adhesion and uptake. These nanotubes provide a robust platform for developing biomimetic materials tailored to specific applications.
- Published
- 2018