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196 results on '"Vlachou A"'

1. Bioinformatics analyses of next generation sequencing Hepatitis C virus samples

Author

Kremyda-Vlachou, Myrto

Abstract

Background: There are 118,000 patients with chronic Hepatitis C virus (HCV) in the UK and the virus is considered a major public health threat by the WHO. Pangenotypic treatment has increased cure rates (>95%), which could reduce the need for subtyping, but currently in the UK genotype-dependent drug combinations are implemented. Injecting drug users are particularly affected and driving transmission. Sequencing could be used at scale to inform the clinical and public treatment of HCV, but the added value of sequencing over current methods for subtyping remains unclear. The aim of this PhD was to explore the utility of HCV WGS to support clinical and public health responses to HCV. Methods: I used the Infection response through virus genomics (ICONIC) pipeline to carry out de novo assembly of 1682 HCV samples and conducted quality control analyses of these genomes. I compared different genotyping tools and investigated whether whole genomes provided more accurate genotyping results compared to specific regions of the HCV genome. I also compared WGS genotyping with genotyping information from a clinical dataset. Lastly, I used clinical and genotype data for phylogenetic and statistical analyses to uncover associations between patient characteristics and transmission clustering. Results: Genotype-specific primers produced lower quality of genomes compared to pan-genotypic primers. WGS is as accurate as NS5B Sanger sequencing in assigning genotypes and subtypes, but was more accurate than 5'UTR and core regions. I found that PWIDs, White ethnicity and being in Glasgow were associated with HCV transmission chains. Conclusion: WGS offers a lot of information in the study of HCV. Its utility in the clinic is questioned due to the high efficacy of the treatments. However, research and surveillance using WGS can help support public health policies to reduce transmission of HCV and can be used to monitor the emergence of drug resistance.

Published
2022

3. Extracting circadian clock information from a single time point assay

Author

Vlachou, Denise F.

Subjects
571.6, QP Physiology
Abstract

A working internal circadian clock allows a healthy organism to keep time in order to anticipate transitions between night and day, allowing the temporal optimisation and control of internal processes. The internal circadian clock is regulated by a set of core genes that form a tightly coupled oscillator system. These oscillators are autonomous and robust to noise, but can be slowly reset by external signals that are processed by the master clock in the brain. In this thesis we explore the robustness of a tightly coupled oscillator model of the circadian clock, and show that its deterministic and stochastic forms are both significantly robust to noise. Using a simple linear algebra approach to rhythmicity detection, we show that a small set of circadian clock genes are rhythmic and synchronised in mouse tissues, and rhythmic and synchronised in a group of human individuals. These sets of tightly regulated, robust oscillators, are genes that we use to de ne the expected behaviour of a healthy circadian clock. We use these “time fingerprints" to design a model, dubbed “Time-Teller", that can be used to tell the time from single time point samples of mouse or human transcriptome. The dysfunction of the molecular circadian clock is implicated in several major diseases and there is significant evidence that disrupted circadian rhythm is a hallmark of many cancers. Convincing results showing the dysfunction of the circadian clock in solid tumours is lacking due to the difficulties of studying circadian rhythms in tumours within living mammals. Instead of developing biological assays to study this, we take advantage of the design of Time-Teller, using its underlying features to build a metric, Θ, that indicates dysfunction of the circadian clock. We use Time-Teller to explore the clock function of samples from existing, publicly available tumour transcriptome data. Although multiple algorithms have been published with the aims of “time-telling" using transcriptome data, none of them have been reported to be able to tell the times of single samples, or provide metrics of clock dysfunction in single samples. Time-Teller is presented in this thesis as an algorithm that both tells the time of a single time-point sample, and provides a measure of clock function for that sample. In a case study, we use the clock function metric, , as a retrospective prognostic marker for breast cancer using data from a completed clinical trial. Θ is shown to correlate with many prognostic markers of breast cancer, and we show how could also be a predictive marker for treatment efficacy and patient survival.

Published
2018

4. 17O solid state NMR study of ceria systems

Author

Vlachou, Maria C.

Subjects
530, QC Physics
Abstract

Ceria is a highly commercial, valuable material. Its diverse set of real-world applications demonstrates its far-reaching influence on modern society. Indeed, one only has to consider its extensive employment as an essential component of automotive, three-way catalysis (TWC) for reducing pollutants in vehicular exhaust gases; a technology that is used on a daily basis by millions of people, to appreciate its importance. Its popularity is partially due to its extraordinary oxygen storage capacity, i.e. its ability to release and store oxygen through redox reactions mediated by the two oxidation states of cerium (Ce3+/Ce4+). This unique ability can be heavily influenced by ceria’s particle size and shape, dopant concentration and surface chemistry, and is still a very active area of research today. Whilst there have been over 26,000 scientific publications on ceria since the 1950s, and although the bulk-ceria oxygen chemical shift (877 ppm) was first observed with 17O solid-state NMR in 1989, it is only within the past decade that solid-state NMR has been employed as a probe for ceria’s structure-function relationships. This study presents an extensive 17O solid-state NMR investigation into various ceria systems, in conjunction with complementary Raman spectroscopy (for which the literature is abundant). An alternative spectral assignment for the 17O NMR spectrum of nanoceria based on experimental deductions and DFT quantum mechanical calculations is proposed. The current working assignment for nanoceria is based on the work of Wang et al., where DFT calculations of a core-shell model are used to deconvolute the NMR data. In contrast to this model, it is suggested that the most upfield peak at δCG = 822 ppm (that is actually part of a multicomponent region centred at ~830 ppm), corresponds to oxygen species displaced from their standard sublattice positions, to occupy a Frenkel type defect site. The resonance regions observed at ~830 and 920 ppm are proposed to be bulk oxygen environments feeling the effects of the Frenkel defect and concomitant oxygen vacancy. For reduced ceria systems, a broad component is detected that spans > 1000 ppm, and is assigned to oxygen directly bonded to Ce3+, in agreement with the current working model. Finally, it is observed that the most deshielded peak at ~1030 ppm is multi-component and (one of these components) possesses an extensive spinning sideband manifold in comparison to the other 17O resonances. Variable temperature investigations show a small inverse temperature dependence of the peak positions, suggesting weak pseudocontact paramagnetic shifts are influencing the spectrum. In light of this, the peak at ~1030 ppm is assigned to oxygen in closer proximity to (but not directly bonded) to Ce3+, as is reported by current 27Al solid-state NMR studies of Ce3+ doped systems and as is reflected by the extensive sideband manifold. The novel 17O preparation treatments implemented in this work were engineered to probe oxygen environments near defects. Ceria’s defects are manipulated by exposure to certain temperature/atmospheric conditions, and when these replicate those of possible catalyst operating temperatures with 17O enriched gas, 17O is able to probe the distribution of oxygen in distinct sites that are important to the OSC process. A prereduction of ceria was therefore implemented, following 17O2 reoxidation to target these sites. This process was also able to identify a surface reorganization mechanism in which a low reoxidation temperature/ pressure of 17O2 is insufficient to reverse the onset of bulk oxygen diffusion induced by the reduction, an effect which is seen to be enhanced with the loading of Pd. Furthermore, the storage of these treated systems dictates the evolution of the 17O species, with an almost closed-system (to air) detecting the pathway of reoxidised oxygen species to more stable sites over time. Ceria zirconia systems are also investigated in this work. The 17O solid-state NMR spectra show an even greater sensitivity to the 17O2 enrichment conditions. The pre-reduction of the systems induces a greater oxygen removal compared to pure ceria, and thus an increase in Ce3+ paramagnetic centres, i.e. the broad component (> 1000 ppm) characterising the oxygen-Ce3+ bond reveals a greater relative intensity. The complication of increasing Ce3+ paramagnetic centres near the 17O adsorption sites is evidenced by the significant loss in 17O spectral resolution. These effects are exacerbated when ceria zirconia is supported with Pd, known to (stably) reduce the state of the system even further. A straight exchange of the 17O isotope in ceria zirconia helps to inhibit these effects, allowing observation of (1) the chemical shift of the bulk-ceria oxygen move to a more shielded position compared to the pure ceria material at 877 ppm (caused by the inherent contraction of the ceria zirconia lattice), and (2) a broad resonance at ~730 ppm, attributed to oxygen species bridging cerium and zirconium.

Published
2017

5. Researching experience in global higher education : a study of international business students in the UK

Author

Vlachou, Maria, Papadopoulos, Dimitris, and Brewis, Jo

Subjects
650.071
Abstract

This thesis explores the experiences of international business studies students in the UK. Their experiences offer vital insights into important, contemporary socio-political processes, which crisscross international student mobility and the changing nature of global higher education. Such political transformations are driven and shaped by both neoliberal post-Fordist social organization, as well as an intensification of control over mobility. More specifically, this thesis suggests that the production and the policing of international students’ experiences in the UK are shaped by the creation of diversified points of control, such as UK Visas and Immigration, international student recruitment agencies, the UK police, universities’ international offices. Inspired by and drawing on the work of Gilles Deleuze and Félix Guattari (1987), Jacques Rancière (1999) and Frigga Haug (1987) this thesis seeks to surface and analyse minor processes of experiencing which evade the regulatory practices of these institutions. I have experimented with two different methodologies – interviews with international business studies students and a memory work collective with international students undertaking PhD research in business studies. The ten in-depth interviews which I conducted with students from diverse ethnic backgrounds gave me multiple insights into the complexity of the international student experience. However, the methodology of memory work has a more prominent role in this thesis, as it provided the possibility to collectively explore and re-work the collective’s experiences. In doing that it uncovered moments of oppression as well as of resistance which usually remain hidden in clichéd accounts of experience. The main themes that emerged from the responses of my participants were: a) the intensification of border controls: student visa restrictions, the threat of deportation and their anxieties around answering the meticulous questions posed by migration agents; and b) the discourse of employability: lifelong learning, the need for self-regulation and self-valorisation, as well as the problematic links between business studies and business in the ‘real world’ under the current precarious times. At the same time, the numerous tactics these students deploy in order to manoeuvre around and beyond these enclosures emerged during the very process of research as well as during the analysis of the empirical data. Some of these tactics are as follows: non-participation in prescribed tuition (seminars especially); creating informal support networks; avoiding responding to or ‘manipulating’ migration agents; using business studies in unpredictable ways. Through my research I seek to participate in the development of new readings of the international student experience, in order to start envisioning our experiences more broadly as active participators in the socio-political conditions which shape our everyday lives. Such new readings of the international student experience can enact new points of entry in both migration as well as labour studies.

Published
2017

6. Repeated local delivery of hyaluronic acid gel as adjunctive treatment of residual pockets in periodontitis patients undergoing supportive periodontal care. A randomized controlled clinical trial

Author

Bertl, Kristina, Vlachou, Stefania, Pandis, Nikolaos, Zampelis, Antonios, Stavropoulos, Andreas, Bertl, Kristina, Vlachou, Stefania, Pandis, Nikolaos, Zampelis, Antonios, and Stavropoulos, Andreas

Abstract

Objectives To assess the effect of hyaluronic acid (HyA) application as adjunct to re-instrumentation of residual pockets in patients undergoing regular supportive periodontal care (SPC). Methods Chronic periodontitis patients (stage III and IV, grade B and C) with 4 interproximal residual pockets were randomly assigned to the test (HyA gel) or control (saline) group. After subgingival instrumentation, test or control substance was applied subgingivally, then daily supragingivally for 3 months, and if required a second time after subgingival re-instrumentation after 3 months. Clinical and patient reported outcome parameters were recorded every 3 months for 12 months. Pocket closure [probing pocket depth (PPD) <= 4mm with absence of bleeding on probing (BoP) at PPD = 4mm] was the main outcome parameter. Results Fifty-six patients (221 experimental sites) were analysed. Pocket closure was achieved in 56.8 and 46.6% of the experimental sites in the test and control group, respectively (p > 0.05), while median PPD and PPD distribution (< 5mm/5mm/ > 5mm) differed significantly between groups in favour of the test group, at 12 months. Further, significantly fewer sites in the HyA group required re-instrumentation at 3 months, and sites in the HyA group showed a tendency for lower odds to remain diseased compared to the control group (OR 0.48, 95%CI 0.22-1.06). The odds for a site to remain diseased after 12 months increased significantly in the presence of plaque (OR 7.94, 95%CI 4.12-15.28), but in general, decreased significantly over time (OR 0.48, 95%CI 0.28-0.81). Conclusion Re-instrumentation of residual pockets in SPC patients, per se, leads to a significant increase in pocket closure over time; this was impeded by poor plaque control. Repeated local application of HyA results in fewer sites requiring re-instrumentation and might slightly improve the rate of pocket closure. (clinicaltrials.gov registration nr. NCT04792541). Clinical relevance HyA gel is

Published
2024
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7. Att arbeta med flerspråkiga elever på fritidshemmet : En kvalitativ studie om lärare i fritidshemmets upplevelser kring undervisningens möjligheter och hinder för flerspråkiga elevers lärande

Author

Göc, William, Vlachou, Sofia, Göc, William, and Vlachou, Sofia

Abstract

Syftet med studien är att undersöka lärare i fritidshemmets upplevelser gällande möjligheter och hinder, samt hur undervisningen anpassas för elevers lärande inom flerspråkighet. För att besvara syftet har följande frågeställningar använts: Vilka möjligheter och hinder uppstår i arbetet med flerspråkighet i fritidshemmets undervisning? Hur anpassar lärare i fritidshemmet undervisningen med flerspråkiga elever? I studien har en kvalitativ metod använts, i form av semistrukturerade intervjuer. Totalt intervjuades sex respondenter från fem olika fritidshem. Studiens resultat visar likheter och skillnader i hur lärare i fritidshem ser hinder och sedan anpassar undervisningen för att möjliggöra flerspråkiga elevers lärande. De arbetar också med bildstöd, läsning, samtal och medvetet förhållningssätt för att utveckla elevernas språkutveckling. Dessutom organiseras den språkutvecklande undervisningen kontinuerligt genom att skapa samtalssituationer för att eleverna ska jämföra ord från sitt modersmål till svenska.

Published
2024

8. Protocols for Quantum Weak Coin Flipping

Author

Arora, Atul Singh, Roland, Jérémie, Vlachou, Chrysoula, Weis, Stephan, Arora, Atul Singh, Roland, Jérémie, Vlachou, Chrysoula, and Weis, Stephan

Abstract

Weak coin flipping is an important cryptographic primitive -- it is the strongest known secure two-party computation primitive that classically becomes secure only under certain assumptions (e.g. computational hardness), while quantumly there exist protocols that achieve arbitrarily close to perfect security. This breakthrough result was established by Mochon in 2007 [arXiv:0711.4114]. However, his proof relied on the existence of certain unitary operators which was established by a non-constructive argument. Consequently, explicit protocols have remained elusive. In this work, we give exact constructions of related unitary operators. These, together with a new formalism, yield a family of protocols approaching perfect security thereby also simplifying Mochon's proof of existence. We illustrate the construction of explicit weak coin flipping protocols by considering concrete examples (from the aforementioned family of protocols) that are more secure than all previously known protocols., Comment: 51 pages (+ 9 appendix), 12 figures. This is a self-contained, concise version of our main results in arXiv:1811.02984 (STOC '19) and arXiv:1911.13283v2 (SODA '21). The Cryptology ePrint 2022/1101 is the comprehensive version, subsuming the above

Published
2024

9. What Else Would I Like? A User Simulator using Alternatives for Improved Evaluation of Fashion Conversational Recommendation Systems

Author

Vlachou, Maria, Macdonald, Craig, Vlachou, Maria, and Macdonald, Craig

Abstract

In Conversational Recommendation Systems (CRS), a user can provide feedback on recommended items at each interaction turn, leading the CRS towards more desirable recommendations. Currently, different types of CRS offer various possibilities for feedback, i.e., natural language feedback, or answering clarifying questions. In most cases, a user simulator is employed for training as well as evaluating the CRS. Such user simulators typically critique the current retrieved items based on knowledge of a single target item. Still, evaluating systems in offline settings with simulators suffers from problems, such as focusing entirely on a single target item (not addressing the exploratory nature of a recommender system), and exhibiting extreme patience (consistent feedback over a large number of turns). To overcome these limitations, we obtain extra judgements for a selection of alternative items in common CRS datasets, namely Shoes and Fashion IQ Dresses. Going further, we propose improved user simulators that allow simulated users not only to express their preferences about alternative items to their original target, but also to change their mind and level of patience. In our experiments using the relative image captioning CRS setting and different CRS models, we find that using the knowledge of alternatives by the simulator can have a considerable impact on the evaluation of existing CRS models, specifically that the existing single-target evaluation underestimates their effectiveness, and when simulated users are allowed to instead consider alternatives, the system can rapidly respond to more quickly satisfy the user.

Published
2024

10. Leak Proof CMap; a framework for training and evaluation of cell line agnostic L1000 similarity methods

Author

Shave, Steven, Kasprowicz, Richard, Athar, Abdullah M., Vlachou, Denise, Carragher, Neil O., Nguyen, Cuong Q., Shave, Steven, Kasprowicz, Richard, Athar, Abdullah M., Vlachou, Denise, Carragher, Neil O., and Nguyen, Cuong Q.

Abstract

The Connectivity Map (CMap) is a large publicly available database of cellular transcriptomic responses to chemical and genetic perturbations built using a standardized acquisition protocol known as the L1000 technique. Databases such as CMap provide an exciting opportunity to enrich drug discovery efforts, providing a 'known' phenotypic landscape to explore and enabling the development of state of the art techniques for enhanced information extraction and better informed decisions. Whilst multiple methods for measuring phenotypic similarity and interrogating profiles have been developed, the field is severely lacking standardized benchmarks using appropriate data splitting for training and unbiased evaluation of machine learning methods. To address this, we have developed 'Leak Proof CMap' and exemplified its application to a set of common transcriptomic and generic phenotypic similarity methods along with an exemplar triplet loss-based method. Benchmarking in three critical performance areas (compactness, distinctness, and uniqueness) is conducted using carefully crafted data splits ensuring no similar cell lines or treatments with shared or closely matching responses or mechanisms of action are present in training, validation, or test sets. This enables testing of models with unseen samples akin to exploring treatments with novel modes of action in novel patient derived cell lines. With a carefully crafted benchmark and data splitting regime in place, the tooling now exists to create performant phenotypic similarity methods for use in personalized medicine (novel cell lines) and to better augment high throughput phenotypic screening technologies with the L1000 transcriptomic technology.

Published
2024

11. Barcode demultiplexing of nanopore sequencing raw signals by unsupervised machine learning

Author

Papetti, D, Spolaor, S, Nazari, I, Tirelli, A, Leonardi, T, Caprioli, C, Besozzi, D, Vlachou, T, Pelicci, P, Cazzaniga, P, Nobile, M, Papetti, Daniele M., Spolaor, Simone, Nazari, Iman, Tirelli, Andrea, Leonardi, Tommaso, Caprioli, Chiara, Besozzi, Daniela, Vlachou, Thalia, Pelicci, Pier Giuseppe, Cazzaniga, Paolo, Nobile, Marco S., Papetti, D, Spolaor, S, Nazari, I, Tirelli, A, Leonardi, T, Caprioli, C, Besozzi, D, Vlachou, T, Pelicci, P, Cazzaniga, P, Nobile, M, Papetti, Daniele M., Spolaor, Simone, Nazari, Iman, Tirelli, Andrea, Leonardi, Tommaso, Caprioli, Chiara, Besozzi, Daniela, Vlachou, Thalia, Pelicci, Pier Giuseppe, Cazzaniga, Paolo, and Nobile, Marco S.

Abstract

Introduction: Oxford Nanopore Technologies (ONT) is a third generation sequencing approach that allows the analysis of individual, full-length nucleic acids. ONT records the alterations of an ionic current flowing across a nano-scaled pore while a DNA or RNA strand is threading through the pore. Basecalling methods are then leveraged to translate the recorded signal back to the nucleic acid sequence. However, basecall generally introduces errors that hinder the process of barcode demultiplexing, a pivotal task in single-cell RNA sequencing that allows for separating the sequenced transcripts on the basis of their cell of origin. Methods: To solve this issue, we present a novel framework, called UNPLEX, designed to tackle the barcode demultiplexing problem by operating directly on the recorded signals. UNPLEX combines two unsupervised machine learning methods: autoencoders and self-organizing maps (SOM). The autoencoders extract compact, latent representations of the recorded signals that are then clustered by the SOM. Results and Discussion: Our results, obtained on two datasets composed of in silico generated ONT-like signals, show that UNPLEX represents a promising starting point for the development of effective tools to cluster the signals corresponding to the same cell.

Published
2023

12. Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Author

Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, Jawa, Randeep, Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, and Jawa, Randeep

Abstract

Background: Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods: This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results: Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions: Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04

Published
2023

13. The Effect of thermal injury and its Management on Systemic Vascular Endothelial Permeability Dysfunction and Tissue Perfusion

Author

Vlachou, Evangelia

Subjects
616.5
Abstract

This is the first attempt at evaluating the systemic endothelial damage/capillary leak following human thermal injury. This was quantified by Microalbuminuria, an immunoassay method for measuring traces of albumin in the urine, expressed as the Albumin Creatinine Ratio (ACR). ACR showed a significant correlation with the proportion of full-thickness burn, inhalation injury, alcohol intoxication and accelerant involvement. The variability in endothelial response to thermal injury between patients is not addressed by standard resuscitation formulae. The initial post-burn ACR was a sensitive predictor of the difference between resuscitation fluid volume predicted and that actually required in the first 24 hours post-injury. Exacerbations of capillary leak occur during post-burn surgical intervention, vary with timing of surgery and are higher in the presence of complications. The potential benefit ofcolloid supplementation in burns resuscitation was assessed. Patients randomised to receive supplemental 6% Hydroxyethylstarch, required smaller resuscitation fluid volumes and demonstrated less total body fluid retention during the first 24 hours post-burn. Tissue perfusion (known to be critical in this injury model) was also studied. Subcutaneous tissue oxygen tension correlated with post-burn ACR. Gastric pH monitoring revealed a degree ofgastric hypoperfusion and predicted physiological patient deterioration before the disturbance of traditional haemodynamic parameters.

Published
2007

14. Teachers and peers attitudes towards the integration of pupils with Down's Syndrome

Author

Vlachou, Anastasia

Subjects
370, School integration, Disabled children
Abstract

This study is an exploratory piece of research into the question of attitudes towards the process of integration. A socio-political approach to attitudes is used as a theoretical framework for exploring and understanding the meanings and the complexities involved in the formation of attitudes. The study considers the case of one primary school in particular, Yorkshire School, that had a policy of integrating, in a cross sectional way, forty pupils identified as having special educational needs, including six pupils with Down's Syndrome. The research involved extensive participant observations within the school, semi-structured interviews and informal discussions with nineteen (19) teachers as well as individual and group discussions with the use of a picture with a hundred and three (103) pupils. The findings of this study show that integration has become a contentious term. Teachers' attitudes are conflicting and often confusing while the directives embedded in the teaching act, especially after the introduction of the Educational Reform Act, render the commitment of inclusive education more difficult to maintain. Further, the exploration of the meanings children ascribe to their interactional and perceptual patternings with disabled peers revealed the ways that "handicapped" identities are being socially created. The value conflicts and ethical dilemmas in which both teachers and pupils are becoming enmeshed as well as the structural conditions within which integration is implemented are discussed in an attempt to show that integration must become a policy oriented towards its own destruction. The findings also confirm the necessity of a socio-political approach in the study of attitudes by revealing that any serious attempt of exploring and understanding the complexities involved in the formation of attitudes towards the integration process cannot be divorced either from the wider set of social formations or from the educational context within which attitudes have been developed in the first place.

Published
1995

15. Loving Coalitions : Seven Texts on Feminist Resistance

Author

Kawesa, Victoria, Vlachou, Maria, Knobblock, Ina, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, Lykke, Nina, Kawesa, Victoria, Vlachou, Maria, Knobblock, Ina, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, and Lykke, Nina

Published
2023

16. The geopolitics of international higher education prior and during Covid-19 : A decolonial feminist analysis

Author

Vlachou, Maria, Tlostanova, Madina, Vlachou, Maria, and Tlostanova, Madina

Abstract

Thinking with four non-EU academic migrants from the global South, andtheir experiences of working/studying or starting to work/study duringthe Covid-19 pandemic, we are unravelling the current geopolitics ofthe internationalised higher education in the global North. Our centralargument is that Covid-19 has not simply affected the national andglobal politics of migration, including international academic migration,but it has also worked as a magnifying glass of the historicallyestablished inequalities sustained and perpetuated by physical,biomedical and epistemic borders. Most importantly, we are notfollowing the rather obvious theoretical route of biopolitics whileanalysing the internationalisation of higher education in relation to theCovid-19 health crisis and migration politics. Instead, we are looking atthis geo-biopolitical and epistemic assemblage through a decoloniallens. In doing so, we want to contribute with our and our interviewees’reflections to the ongoing discussion on what currently counts as‘internationalisation’ in higher education, pointing out the colononialand neoliberal foundations of it, and the possibilities of aligning it withthe efforts of decolonising the university.

Published
2023
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17. The magic of feminist bridging : A mosaic of anti-racist speech bubblesabout Othering in Swedish Academia

Author

Kawesa, Victoria, Knobblock, Ina, Vlachou, Maria, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, Lykke, Nina, Kawesa, Victoria, Knobblock, Ina, Vlachou, Maria, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, and Lykke, Nina

Abstract

Are feminist coalitions magical enough to survive and endure while questioning and shaking the colonial/racist foundations of Swedish academic knowledge production and the overall Swedish society? Can feminist bridging and collective writing remain a magical process even when grappling with difficult experiences and memories of othering and racialisation? This is a creatively and collectively written article on feminist coalition building, and its importance in thinking, articulating and deconstructing race, racialization and racist structures. More than two years ago, seven interdisciplinary gender studies scholars of mixed ethnic and racial origins, came together to explore our differently situated experiences of disidentifying with Swedish academia and society in a collective we call Loving Coalitions. Against the background of Swedish exceptionalism, historical amnesia of Sweden’s colonial past and present, and the deafening silence on Swedish whiteness and racism, we are sharing our poems, letters, texts and testimonies of racist interactions in Swedish academia and society. While doing so, we discuss how moving away from conventional ways of doing research and experimenting with creative methodological alternatives, such as automatic writing, epistolary formats, poems, fiction, collective memory-work, allow us to acknowledge and embrace our different life backgrounds and academic trajectories as a mode of knowledge production. We hope and believe that our experiences, refl ections and ways to resist racism and Othering in Sweden and Swedish academia through alternative coalition building, based on mutual care and love, can be relevant in a Danish context as well.

Published
2023

18. The magic of feminist bridging : A mosaic of anti-racist speech bubbles about Othering in Swedish Academia

Author

Kawesa, Victoria, Knobblock, Ina, Vlachou, Maria, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, Lykke, Nina, Kawesa, Victoria, Knobblock, Ina, Vlachou, Maria, Koobak, Redi, Mehrabi, Tara, Tlostanova, Madina, and Lykke, Nina

Abstract

Are feminist coalitions magical enough to survive and endure while questioning and shaking the colonial/racist foundations of Swedish academic knowledge production and the overall Swedish society? Can feminist bridging and collective writing remain a magical process even when grappling with diffi cult ex-periences and memories of Othering and racialization? This is a creatively and collectively written article on feminist coalition building, and its importance in thinking, articulating and deconstructing race, racial-ization and racist structures. More than two years ago, seven interdisciplinary gender studies scholars of mixed ethnic and racial origins, came together to explore our differently situated experiences of disidenti-fying with Swedish academia and society in a collective we call Loving Coalitions (capital initials). Against the background of Swedish exceptionalism, historical amnesia of Sweden’s colonial past and present, and the deafening silence on Swedish whiteness and racism, we are sharing our poems, letters, texts and testimonies of racist interactions in Swedish academia and society. While doing so, we discuss how moving away from conventional ways of doing research and experimenting with creative methodological alternatives allow us to acknowledge and embrace our different life backgrounds and academic trajecto-ries as a mode of knowledge production. We hope and believe that our experiences, reflections and ways to resist racism and Othering in Sweden and Swedish academia through alternative coalition building, based on mutual care and love, can be relevant in a Danish context as well.

Published
2023
Full Text
View/download PDF

19. Hyper-Local Weather Predictions with the Enhanced General Urban Area Microclimate Predictions Tool

Author

1788650, 1570403, 0713565, Adkins, Kevin A., Becker, William, Ayyalasomayajula, Sricharan, Lavenstein, Steven, Vlachou, Kleoniki, Miller, David, Compere, Marc, Krishnan, Avinash Muthu, Macchiarella, Nickolas, 1788650, 1570403, 0713565, Adkins, Kevin A., Becker, William, Ayyalasomayajula, Sricharan, Lavenstein, Steven, Vlachou, Kleoniki, Miller, David, Compere, Marc, Krishnan, Avinash Muthu, and Macchiarella, Nickolas

Abstract

This paper presents enhancements to, and the demonstration of, the General Urban area Microclimate Predictions tool (GUMP), which is designed to provide hyper-local weather predictions by combining machine-learning (ML) models and computational fluid dynamic (CFD) simulations. For the further development and demonstration of GUMP, the Embry–Riddle Aeronautical University (ERAU) campus was used as a test environment. Local weather sensors provided data to train ML models, and CFD models of urban- and suburban-like areas of ERAU’s campus were created and iterated through with a wide assortment of inlet wind speed and direction combinations. ML weather sensor predictions were combined with best-fit CFD models from a database of CFD flow fields, providing flight operational areas with a fully expressed wind flow field. This field defined a risk map for uncrewed aircraft operators based on flight plans and individual flight performance metrics. The potential applications of GUMP are significant due to the immediate availability of weather predictions and its ability to easily extend to arbitrary urban and suburban locations.

Published
2023

20. Barcode demultiplexing of nanopore sequencing raw signals by unsupervised machine learning

Author

Papetti, Daniele M., Spolaor, Simone, Nazari, Iman, Tirelli, Andrea, Leonardi, Tommaso, Caprioli, Chiara, Besozzi, Daniela, Vlachou, Thalia, Pelicci, Pier Giuseppe, Cazzaniga, Paolo, Nobile, Marco S., Papetti, Daniele M., Spolaor, Simone, Nazari, Iman, Tirelli, Andrea, Leonardi, Tommaso, Caprioli, Chiara, Besozzi, Daniela, Vlachou, Thalia, Pelicci, Pier Giuseppe, Cazzaniga, Paolo, and Nobile, Marco S.

Abstract

Introduction: Oxford Nanopore Technologies (ONT) is a third generation sequencing approach that allows the analysis of individual, full-length nucleic acids. ONT records the alterations of an ionic current flowing across a nano-scaled pore while a DNA or RNA strand is threading through the pore. Basecalling methods are then leveraged to translate the recorded signal back to the nucleic acid sequence. However, basecall generally introduces errors that hinder the process of barcode demultiplexing, a pivotal task in single-cell RNA sequencing that allows for separating the sequenced transcripts on the basis of their cell of origin. Methods: To solve this issue, we present a novel framework, called UNPLEX, designed to tackle the barcode demultiplexing problem by operating directly on the recorded signals. UNPLEX combines two unsupervised machine learning methods: autoencoders and self-organizing maps (SOM). The autoencoders extract compact, latent representations of the recorded signals that are then clustered by the SOM. Results and Discussion: Our results, obtained on two datasets composed of in silico generated ONT-like signals, show that UNPLEX represents a promising starting point for the development of effective tools to cluster the signals corresponding to the same cell.

Published
2023

21. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022

Author

Pennazio, M., Rondonotti, E., Despott, E. J., Dray, X., Keuchel, M., Moreels, T., Sanders, D. S., Spada, Cristiano, Carretero, C., Cortegoso Valdivia, P., Elli, L., Fuccio, L., Gonzalez Suarez, B., Koulaouzidis, A., Kunovsky, L., Mcnamara, D., Neumann, H., Perez-Cuadrado-Martinez, E., Perez-Cuadrado-Robles, E., Piccirelli, Stefania, Rosa, B., Saurin, J. -C., Sidhu, R., Tacheci, I., Vlachou, E., Triantafyllou, K., Spada C. (ORCID:0000-0002-5692-0960), Piccirelli S., Pennazio, M., Rondonotti, E., Despott, E. J., Dray, X., Keuchel, M., Moreels, T., Sanders, D. S., Spada, Cristiano, Carretero, C., Cortegoso Valdivia, P., Elli, L., Fuccio, L., Gonzalez Suarez, B., Koulaouzidis, A., Kunovsky, L., Mcnamara, D., Neumann, H., Perez-Cuadrado-Martinez, E., Perez-Cuadrado-Robles, E., Piccirelli, Stefania, Rosa, B., Saurin, J. -C., Sidhu, R., Tacheci, I., Vlachou, E., Triantafyllou, K., Spada C. (ORCID:0000-0002-5692-0960), and Piccirelli S.

Abstract

n/a

Published
2023

22. On Coherence-based Predictors for Dense Query Performance Prediction

Author

Vlachou, Maria, Macdonald, Craig, Vlachou, Maria, and Macdonald, Craig

Abstract

Query Performance Prediction (QPP) estimates the effectiveness of a search engine's results in response to a query without relevance judgments. Traditionally, post-retrieval predictors have focused upon either the distribution of the retrieval scores, or the coherence of the top-ranked documents using traditional bag-of-words index representations. More recently, BERT-based models using dense embedded document representations have been used to create new predictors, but mostly applied to predict the performance of rankings created by BM25. Instead, we aim to predict the effectiveness of rankings created by single-representation dense retrieval models (ANCE & TCT-ColBERT). Therefore, we propose a number of variants of existing unsupervised coherence-based predictors that employ neural embedding representations. In our experiments on the TREC Deep Learning Track datasets, we demonstrate improved accuracy upon dense retrieval (up to 92% compared to sparse variants for TCT-ColBERT and 188% for ANCE). Going deeper, we select the most representative and best performing predictors to study the importance of differences among predictors and query types on query performance. Using existing distribution-based evaluation QPP measures and a particular type of linear mixed models, we find that query types further significantly influence query performance (and are up to 35% responsible for the unstable performance of QPP predictors), and that this sensitivity is unique to dense retrieval models. Our approach introduces a new setting for obtaining richer information on query differences in dense QPP that can explain potential unstable performance of existing predictors and outlines the unique characteristics of different query types on dense retrieval models.

Published
2023

23. An Experimental and Computational Protocol to Study Cell Proliferation in Human Acute Myeloid Leukemia Xenografts

Author

Cobaleda, C, Sánchez-García, I, Vlachou, T, Nobile, M, Ronchini, C, Besozzi, D, Pelicci, P, Vlachou, Thalia, Nobile, Marco S, Ronchini, Chiara, Besozzi, Daniela, Pelicci, Pier Giuseppe, Cobaleda, C, Sánchez-García, I, Vlachou, T, Nobile, M, Ronchini, C, Besozzi, D, Pelicci, P, Vlachou, Thalia, Nobile, Marco S, Ronchini, Chiara, Besozzi, Daniela, and Pelicci, Pier Giuseppe

Abstract

Acute myeloid leukemia (AML) is a highly frequent hematological malignancy, characterized by clinical and biological diversity, along with high relapse and mortality rates. The inherent functional and genetic intra-tumor heterogeneity in AML is thought to play an important role in disease recurrence and resistance to chemotherapy. Patient-derived xenograft (PDX) models preserve important features of the original tumor, allowing, at the same time, experimental manipulation and in vivo amplification of the human cells. Here we present a detailed protocol for the generation of fluorescently labeled AML PDX models to monitor cell proliferation kinetics in vivo, at the single-cell level. Although experimental protocols for cell proliferation studies are well established and widespread, they are not easily applicable to in vivo contexts, and the analysis of related time-series data is often complex to achieve. To overcome these limitations, model-driven approaches can be exploited to investigate different aspects of cell population dynamics. Among the existing approaches, the ProCell framework is able to perform detailed and accurate stochastic simulations of cell proliferation, relying on flow cytometry data. In particular, by providing an initial and a target fluorescence histogram, ProCell automatically assesses the validity of any user-defined scenario of intra-tumor heterogeneity, that is, it is able to infer the proportion of various cell subpopulations (including quiescent cells) and the division interval of proliferating cells. Here we explain the protocol in detail, providing a description of our methodology for the conditional expression of H2B-GFP in human AML xenografts, data processing by flow cytometry, and the final elaboration in ProCell.

Published
2021

24. The impact of the COVID-19 pandemic on people with diabetes and diabetes services: A pan-European survey of diabetes specialist nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium

Author

Forde, R, Arente, L, Ausili, D, De Backer, K, Due-Christensen, M, Epps, A, Fitzpatrick, A, Grixti, M, Groen, S, Halkoaho, A, Huber, C, Iversen, M, Johansson, U, Leippert, C, Ozcan, S, Parker, J, Paiva, A, Sanpetreanu, A, Savet, M, Rosana, S, Szewczyk, A, Valverde, M, Vlachou, E, Forbes, A, Allen-Taylor, M, Brown, F, Celick, A, Gane, S, Hashem, R, Habete-Asres, H, Tian, Q, Sturt, J, Winkley, K, Caron, R, Gacina, S, Moloney, Y, Kobos, E, Jansa, M, Yoldi, C, Forde R., Arente L., Ausili D., De Backer K., Due-Christensen M., Epps A., Fitzpatrick A., Grixti M., Groen S., Halkoaho A., Huber C., Iversen M. M., Johansson U. -B., Leippert C., Ozcan S., Parker J., Paiva A. C., Sanpetreanu A., Savet M. -A., Rosana S. -C., Szewczyk A., Valverde M., Vlachou E., Forbes A., Allen-Taylor M., Brown F., Celick A., Gane S., Hashem R., Habete-Asres H., Tian Q., Sturt J., Winkley K., Caron R., Gacina S., Moloney Y., Kobos E., Jansa M., Yoldi C., Forde, R, Arente, L, Ausili, D, De Backer, K, Due-Christensen, M, Epps, A, Fitzpatrick, A, Grixti, M, Groen, S, Halkoaho, A, Huber, C, Iversen, M, Johansson, U, Leippert, C, Ozcan, S, Parker, J, Paiva, A, Sanpetreanu, A, Savet, M, Rosana, S, Szewczyk, A, Valverde, M, Vlachou, E, Forbes, A, Allen-Taylor, M, Brown, F, Celick, A, Gane, S, Hashem, R, Habete-Asres, H, Tian, Q, Sturt, J, Winkley, K, Caron, R, Gacina, S, Moloney, Y, Kobos, E, Jansa, M, Yoldi, C, Forde R., Arente L., Ausili D., De Backer K., Due-Christensen M., Epps A., Fitzpatrick A., Grixti M., Groen S., Halkoaho A., Huber C., Iversen M. M., Johansson U. -B., Leippert C., Ozcan S., Parker J., Paiva A. C., Sanpetreanu A., Savet M. -A., Rosana S. -C., Szewczyk A., Valverde M., Vlachou E., Forbes A., Allen-Taylor M., Brown F., Celick A., Gane S., Hashem R., Habete-Asres H., Tian Q., Sturt J., Winkley K., Caron R., Gacina S., Moloney Y., Kobos E., Jansa M., and Yoldi C.

Abstract

Aim: To describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe. Methods: An online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks. Results: Survey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n = 504) and 48% (n = 873) of diabetes nurses felt the COVID-19 pandemic had impacted ‘a lot’ on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased ‘a lot’: anxiety 82% (n = 1486); diabetes distress 65% (n = 1189); depression 49% (n = 893); acute hyperglycaemia 39% (n = 710) and foot complications 18% (n = 323). Forty-seven percent (n = 771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n = 499), 63% (n = 1,027) and 34% (n = 551), respectively. Conclusion: The findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues, we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population.

Published
2021

25. A pre-registered, multi-lab non-replication of the action-sentence compatibility effect (ACE)

Author

Morey, Richard D., Kaschak, Michael P., Díez-Álamo, Antonio M., Glenberg, Arthur M., Zwaan, Rolf A., Lakens, Daniël, Ibáñez, Agustín, García, Adolfo, Gianelli, Claudia, Jones, John L., Madden, Julie, Alifano, Florencia, Bergen, Benjamin, Bloxsom, Nicholas G., Bub, Daniel N., Cai, Zhenguang G., Chartier, Christopher R., Chatterjee, Anjan, Conwell, Erin, Cook, Susan Wagner, Davis, Joshua D., Evers, Ellen R.K., Girard, Sandrine, Harter, Derek, Hartung, Franziska, Herrera, Eduar, Huettig, Falk, Humphries, Stacey, Juanchich, Marie, Kühne, Katharina, Lu, Shulan, Lynes, Tom, Masson, Michael E.J., Ostarek, Markus, Pessers, Sebastiaan, Reglin, Rebecca, Steegen, Sara, Thiessen, Erik D., Thomas, Laura E., Trott, Sean, Vandekerckhove, Joachim, Vanpaemel, Wolf, Vlachou, Maria, Williams, Kristina, Ziv-Crispel, Noam, Morey, Richard D., Kaschak, Michael P., Díez-Álamo, Antonio M., Glenberg, Arthur M., Zwaan, Rolf A., Lakens, Daniël, Ibáñez, Agustín, García, Adolfo, Gianelli, Claudia, Jones, John L., Madden, Julie, Alifano, Florencia, Bergen, Benjamin, Bloxsom, Nicholas G., Bub, Daniel N., Cai, Zhenguang G., Chartier, Christopher R., Chatterjee, Anjan, Conwell, Erin, Cook, Susan Wagner, Davis, Joshua D., Evers, Ellen R.K., Girard, Sandrine, Harter, Derek, Hartung, Franziska, Herrera, Eduar, Huettig, Falk, Humphries, Stacey, Juanchich, Marie, Kühne, Katharina, Lu, Shulan, Lynes, Tom, Masson, Michael E.J., Ostarek, Markus, Pessers, Sebastiaan, Reglin, Rebecca, Steegen, Sara, Thiessen, Erik D., Thomas, Laura E., Trott, Sean, Vandekerckhove, Joachim, Vanpaemel, Wolf, Vlachou, Maria, Williams, Kristina, and Ziv-Crispel, Noam

Abstract

The Action-sentence Compatibility Effect (ACE) is a well-known demonstration of the role of motor activity in the comprehension of language. Participants are asked to make sensibility judgments on sentences by producing movements toward the body or away from the body. The ACE is the finding that movements are faster when the direction of the movement (e.g., toward) matches the direction of the action in the to-be-judged sentence (e.g., Art gave you the pen describes action toward you). We report on a pre-registered, multi-lab replication of one version of the ACE. The results show that none of the 18 labs involved in the study observed a reliable ACE, and that the meta-analytic estimate of the size of the ACE was essentially zero.

Published
2022

26. Metabolite Production in Alkanna tinctoria Links Plant Development with the Recruitment of Individual Members of Microbiome Thriving at the Root-Soil Interface

Author

UCL - SST/ELI - Earth and Life Institute, Csorba, Cintia, Rodić, Nebojša, Zhao, Yanyan, Antonielli, Livio, Brader, Günter, Vlachou, Angeliki, Tsiokanos, Evangelia, Lalaymia, Ismahen, Declerck, Stéphane, Papageorgiou, Vassilios P., Assimopoulou, Andreana N., Sessitsch, Angela, Bulgarelli, Davide, UCL - SST/ELI - Earth and Life Institute, Csorba, Cintia, Rodić, Nebojša, Zhao, Yanyan, Antonielli, Livio, Brader, Günter, Vlachou, Angeliki, Tsiokanos, Evangelia, Lalaymia, Ismahen, Declerck, Stéphane, Papageorgiou, Vassilios P., Assimopoulou, Andreana N., Sessitsch, Angela, and Bulgarelli, Davide

Abstract

Plants are naturally associated with diverse microbial communities, which play significant roles in plant performance, such as growth promotion or fending off pathogens. The roots of Alkanna tinctoria L. are rich in naphthoquinones, particularly the medicinally used enantiomers alkannin and shikonin and their derivatives. Former studies already have shown that microorganisms may modulate plant metabolism. To further investigate the potential interaction between A. tinctoria and associated microorganisms, we performed a greenhouse experiment in which A. tinctoria plants were grown in the presence of three distinct soil microbiomes. At four defined plant developmental stages, we made an in-depth assessment of bacterial and fungal root-associated microbiomes as well as all extracted primary and secondary metabolite content of root material. Our results showed that the plant developmental stage was the most important driver influencing the plant metabolite content, revealing peak contents of alkannin/shikonin derivatives at the fruiting stage. Plant root microbial diversity was influenced both by bulk soil origin and to a small extent by the developmental stage. The performed correlation analyses and cooccurrence networks on the measured metabolite content and the abundance of individual bacterial and fungal taxa suggested a dynamic and at times positive or negative relationship between root-associated microorganisms and root metabolism. In particular, the bacterial genera Labrys and Allorhizobium-Neorhizobium-Pararhizobium-Rhizobium as well as four species of the fungal genus Penicillium were found to be positively correlated with higher content of alkannins. IMPORTANCE Previous studies have shown that individual, isolated microorganisms may influence secondary metabolism of plants and induce or stimulate the production of medicinally relevant secondary metabolism. Here, we analyzed the microbiome-metabolome linkage of the medicinal plant Alkanna tinctoria, which is kn

Published
2022

27. Simulations of Point Processes on Directed Graphs

Author

Vlachou, Stavroula Rafailia and Vlachou, Stavroula Rafailia

Abstract

Simulating a point process where the events correspond to vehicle collisions on a road networkcan be quite computationally heavy due to the large number of elements that are necessary toprovide a sufficient discretization of the network. This paper aims to present a computationallyefficient solution for simulating events of a point process. With this goal in mind, an end to endapplication is developed that starts by constructing a discretization of the road graph to represent the state space of the process and associating accidents with elements of the roadgraph, and goes on to simulate events of the process from one or more realisations. The simulation of events is done in a two-level approach; first the arrival times are obtained via inversion and then the incidents are located on the graph by sampling from the conditional distribution of the states given the arrival times. Even though the state space is constructed fromhundreds of thousands of edges and vertices, the application is relatively efficient in terms of computing time and given enough compute nodes in a distributed computing framework is ableto scale to arbitrarily large state spaces. Future work shall revolve around a finer partitioning of the road network and the incorporation of additional characteristics of the events, under a marked point process.

Published
2022

28. A pre-registered, multi-lab non-replication of the action-sentence compatibility effect (ACE).

Author

Morey, Richard D, Morey, Richard D, Kaschak, Michael P, Díez-Álamo, Antonio M, Glenberg, Arthur M, Zwaan, Rolf A, Lakens, Daniël, Ibáñez, Agustín, García, Adolfo, Gianelli, Claudia, Jones, John L, Madden, Julie, Alifano, Florencia, Bergen, Benjamin, Bloxsom, Nicholas G, Bub, Daniel N, Cai, Zhenguang G, Chartier, Christopher R, Chatterjee, Anjan, Conwell, Erin, Cook, Susan Wagner, Davis, Joshua D, Evers, Ellen RK, Girard, Sandrine, Harter, Derek, Hartung, Franziska, Herrera, Eduar, Huettig, Falk, Humphries, Stacey, Juanchich, Marie, Kühne, Katharina, Lu, Shulan, Lynes, Tom, Masson, Michael EJ, Ostarek, Markus, Pessers, Sebastiaan, Reglin, Rebecca, Steegen, Sara, Thiessen, Erik D, Thomas, Laura E, Trott, Sean, Vandekerckhove, Joachim, Vanpaemel, Wolf, Vlachou, Maria, Williams, Kristina, Ziv-Crispel, Noam, Morey, Richard D, Morey, Richard D, Kaschak, Michael P, Díez-Álamo, Antonio M, Glenberg, Arthur M, Zwaan, Rolf A, Lakens, Daniël, Ibáñez, Agustín, García, Adolfo, Gianelli, Claudia, Jones, John L, Madden, Julie, Alifano, Florencia, Bergen, Benjamin, Bloxsom, Nicholas G, Bub, Daniel N, Cai, Zhenguang G, Chartier, Christopher R, Chatterjee, Anjan, Conwell, Erin, Cook, Susan Wagner, Davis, Joshua D, Evers, Ellen RK, Girard, Sandrine, Harter, Derek, Hartung, Franziska, Herrera, Eduar, Huettig, Falk, Humphries, Stacey, Juanchich, Marie, Kühne, Katharina, Lu, Shulan, Lynes, Tom, Masson, Michael EJ, Ostarek, Markus, Pessers, Sebastiaan, Reglin, Rebecca, Steegen, Sara, Thiessen, Erik D, Thomas, Laura E, Trott, Sean, Vandekerckhove, Joachim, Vanpaemel, Wolf, Vlachou, Maria, Williams, Kristina, and Ziv-Crispel, Noam

Abstract

The Action-sentence Compatibility Effect (ACE) is a well-known demonstration of the role of motor activity in the comprehension of language. Participants are asked to make sensibility judgments on sentences by producing movements toward the body or away from the body. The ACE is the finding that movements are faster when the direction of the movement (e.g., toward) matches the direction of the action in the to-be-judged sentence (e.g., Art gave you the pen describes action toward you). We report on a pre-registered, multi-lab replication of one version of the ACE. The results show that none of the 18 labs involved in the study observed a reliable ACE, and that the meta-analytic estimate of the size of the ACE was essentially zero.

Published
2022

29. An entropic safety catch controls hepatitis C virus entry and antibody resistance

Author

Stejskal, Lenka, Kalemera, Mphatso D., Lewis, Charlotte B., Palor, Machaela, Walker, Lucas, Daviter, Tina, Lees, William D., Moss, David S., Kremyda-Vlachou, Myrto, Kozlakidis, Zisis, Gallo, Giulia, Bailey, Dalan, Rosenberg, William, Illingworth, Christopher J. R., Shepherd, Adrian J., Grove, Joe, Stejskal, Lenka, Kalemera, Mphatso D., Lewis, Charlotte B., Palor, Machaela, Walker, Lucas, Daviter, Tina, Lees, William D., Moss, David S., Kremyda-Vlachou, Myrto, Kozlakidis, Zisis, Gallo, Giulia, Bailey, Dalan, Rosenberg, William, Illingworth, Christopher J. R., Shepherd, Adrian J., and Grove, Joe

Abstract

E1 and E2 (E1E2), the fusion proteins of Hepatitis C Virus (HCV), are unlike that of any other virus yet described, and the detailed molecular mechanisms of HCV entry/fusion remain unknown. Hypervariable region-1 (HVR-1) of E2 is a putative intrinsically disordered protein tail. Here, we demonstrate that HVR-1 has an autoinhibitory function that suppresses the activity of E1E2 on free virions; this is dependent on its conformational entropy. Thus, HVR-1 is akin to a safety catch that prevents premature triggering of E1E2 activity. Crucially, this mechanism is turned off by host receptor interactions at the cell surface to allow entry. Mutations that reduce conformational entropy in HVR-1, or genetic deletion of HVR-1, turn off the safety catch to generate hyper-reactive HCV that exhibits enhanced virus entry but is thermally unstable and acutely sensitive to neutralising antibodies. Therefore, the HVR-1 safety catch controls the efficiency of virus entry and maintains resistance to neutralising antibodies. This discovery provides an explanation for the ability of HCV to persist in the face of continual immune assault and represents a novel regulatory mechanism that is likely to be found in other viral fusion machinery.

Published
2022

30. Progressive slowing of clonic phase predicts postictal generalized EEG suppression

Author

Vlachou, Maria, Ryvlin, Philippe, Arbune, Anca Adriana, Armand Larsen, Sidsel, Skræp Sidaros, Annette, Cacic Hribljan, Melita, Fabricius, Martin, Beniczky, Sándor, Vlachou, Maria, Ryvlin, Philippe, Arbune, Anca Adriana, Armand Larsen, Sidsel, Skræp Sidaros, Annette, Cacic Hribljan, Melita, Fabricius, Martin, and Beniczky, Sándor

Abstract

Objective: Postictal generalized electroencephalography (EEG) suppression (PGES) is a surrogate marker of sudden unexpected death in epilepsy (SUDEP). It is still unclear which ictal phenomena lead to prolonged PGES and increased risk of SUDEP. Semiology features of generalized convulsive seizure (GCS type 1) have been reported as a predictor of prolonged PGES. Progressive slowing of clonic phase (PSCP) has been observed in GCSs, with gradually increasing inhibitory periods interrupting the tonic contractions. We hypothesized that PSCP is associated with prolonged PGES. Methods: We analyzed 90 bilateral convulsive seizures in 50 consecutive patients (21 female; age: 11–62 years, median: 31 years) recruited to video-EEG monitoring. Five raters, blinded to all other data, independently assessed the presence of PSCP. PGES and seizure semiology were evaluated independently. We determined inter-rater agreement (IRA) for the presence of PSCP, and we evaluated its association, as well as that of other ictal features, with the occurrence of PGES, prolonged PGES (≥20 s) and very prolonged PGES (≥50 s) using multivariate logistic regression analysis. Results: We found substantial IRA for the presence of PSCP (percent agreement: 80%; beyond-chance agreement coefficient:.655). PSCP was an independent predictor of the occurrence of PGES and prolonged PGES (p <.001). All seizures with very prolonged PGES had PSCP. GCS type 1 was an independent predictor of occurrence of PGES (p =.02) and prolonged PGES (p =.03) but not of very prolonged PGES. Only half of the seizures with very prolonged PGES were GCS type 1. Significance: PSCP predicts prolonged PGES, emphasizing the importance of gradually increasing inhibitory phenomena at the end of the seizures. Our findings shed more light on the ictal phenomena leading to increased risk of SUDEP. These phenomena may provide basis for algorithms implemented into wearable devices for identifying GCS with increased risk of SUDEP.

Published
2022

31. Solutions to quantum weak coin flipping

Author

Arora, Atul Singh, Roland, Jérémie, Vlachou, Chrysoula, Weis, Stephan, Arora, Atul Singh, Roland, Jérémie, Vlachou, Chrysoula, and Weis, Stephan

Abstract

info:eu-repo/semantics/published

Published
2022

32. cuProCell: GPU-Accelerated Analysis of Cell Proliferation With Flow Cytometry Data

Author

Nobile, M, Nisoli, E, Vlachou, T, Spolaor, S, Cazzaniga, P, Mauri, G, Pelicci, P, Besozzi, D, Nobile, Marco S, Nisoli, Eric, Vlachou, Thalia, Spolaor, Simone, Cazzaniga, Paolo, Mauri, Giancarlo, Pelicci, Pier Giuseppe, Besozzi, Daniela, Nobile, M, Nisoli, E, Vlachou, T, Spolaor, S, Cazzaniga, P, Mauri, G, Pelicci, P, Besozzi, D, Nobile, Marco S, Nisoli, Eric, Vlachou, Thalia, Spolaor, Simone, Cazzaniga, Paolo, Mauri, Giancarlo, Pelicci, Pier Giuseppe, and Besozzi, Daniela

Abstract

The investigation of cell proliferation can provide useful insights for the comprehension of cancer progression, resistance to chemotherapy and relapse. To this aim, computational methods and experimental measurements based on in vivo label-retaining assays can be coupled to explore the dynamic behavior of tumoral cells. ProCell is a software that exploits flow cytometry data to model and simulate the kinetics of fluorescence loss that is due to stochastic events of cell division. Since the rate of cell division is not known, ProCell embeds a calibration process that might require thousands of stochastic simulations to properly infer the parameterization of cell proliferation models. To mitigate the high computational costs, in this paper we introduce a parallel implementation of ProCell's simulation algorithm, named cuProCell, which leverages Graphics Processing Units (GPUs). Dynamic Parallelism was used to efficiently manage the cell duplication events, in a radically different way with respect to common computing architectures. We present the advantages of cuProCell for the analysis of different models of cell proliferation in Acute Myeloid Leukemia (AML), using data collected from the spleen of human xenografts in mice. We show that, by exploiting GPUs, our method is able to not only automatically infer the models' parameterization, but it is also 237× faster than the sequential implementation. This study highlights the presence of a relevant percentage of quiescent and potentially chemoresistant cells in AML in vivo, and suggests that maintaining a dynamic equilibrium among the different proliferating cell populations might play an important role in disease progression.

Published
2020

33. Evaluation of Adjuvant Chemotherapy-Associated Steatosis (CAS) in Colorectal Cancer

Author

Lee, MCM, Kachura, JJ, Vlachou, PA, Dzulynsky, R, Di Tomaso, A, Samawi, H, Baxter, N, Brezden-Masley, C, Lee, MCM, Kachura, JJ, Vlachou, PA, Dzulynsky, R, Di Tomaso, A, Samawi, H, Baxter, N, and Brezden-Masley, C

Abstract

Chemotherapy-associated steatosis is poorly understood in the context of colorectal cancer. In this study, Stage II-III colorectal cancer patients were retrospectively selected to evaluate the frequency of chemotherapy-associated steatosis and to determine whether patients on statins throughout adjuvant chemotherapy develop chemotherapy-associated steatosis at a lower frequency. Baseline and incident steatosis for up to one year from chemotherapy start date was assessed based on radiology. Of 269 patients, 76 (28.3%) had steatosis at baseline. Of the remaining 193 cases, patients receiving adjuvant chemotherapy (n = 135) had 1.57 (95% confidence interval [CI], 0.89 to 2.79) times the adjusted risk of developing steatosis compared to patients not receiving chemotherapy (n = 58). Among patients who underwent chemotherapy, those using statins for pre-existing hyperlipidemia (n = 37) had 0.71 (95% CI, 0.10 to 2.75) times the risk of developing steatosis compared to patients who were not prevalent users of statins (n = 98). Chemotherapeutic treatment of Stage II-III colorectal cancer appears to be consistent with a moderately increased risk of steatosis, although larger studies are necessary to assess the significance of this observation. Prospective trials should be considered to further explore the potential for protective use of statins in this curative patient population.

Published
2021

34. Cannabidiol does not cause significant changes to working memory performance in the N-Back task

Author

Jones, Éamon, Vlachou, Styliani, Jones, Éamon, and Vlachou, Styliani

Abstract

Cannabis use can be traced back to several centuries before the Common Era, when it was used for industrial, medicinal and recreational purposes. More recently, over 100 different cannabinoid compounds have been identified, one of which is cannabidiol (CBD), a compound widely used for anti-inflammatory and anxiolytic treatment. The literature surrounding the cognitive effects of CBD is limited, with most studies focusing on the effects of other cannabinoids on cognition. To expand this literature, this study investigated whether CBD causes significant differences to working memory (WM) functioning, as measured by the N-back task. It was hypothesised that CBD does not cause statistically significant differences to WM. In all, 54 participants, 33 females and 21 males, were recruited, with a mean age of 32.63 years. Of these 54 participants, 26 reported using CBD and no other cannabinoids, while 28 reported not using any cannabinoid. The participants were instructed to answer a short online survey to gather basic demographic data and to complete an online N-back task to measure WM. For the computerised N-back task, the participants completed a practice and three test blocks, where they were instructed to respond to whether a series of letter stimuli were presented one trial back (1-back), two trials back (2-back) or three trials back (3-back). Multivariate analysis of covariance yielded no statistically significant difference on either response time or response accuracy data between groups after controlling for how long the participants use CBD and for what reason they use CBD. These results support our hypothesis that CBD does not cause significant changes to WM functioning. Further research is greatly needed to investigate the long-term effects of CBD use on WM and on general cognitive functioning

Published
2021

35. Death following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic

Author

Mclean, K. A., Kamarajah, S. K., Chaudhry, D., Gujjuri, R. R., Raubenheimer, K., Trout, I., Alameer, E., Creagh-Brown, B., Harrison, E. M., Nepogodiev, D., Roslani, A. C., Li, E., Pata, F., Ramos-De la Medina, A., Van Ramshorst, G. H., Sayyed, R., Simoes, J., Smart, N., Bhangu, A., Glasbey, J. C., Khaw, R. A., Ahmed, W., Akhbari, M., Baker, D., Borakati, A., Mills, E., Murray, V., Thavayogan, R., Yasin, I., Glasbey, J., Ridley, W., Sarrami, M., Zhang, G., Egoroff, N., Pockney, P., Richards, T., Edwards, M., Lee, M., Pinkney, T., Pearse, R., Vohra, R., Sohrabi, C., Jamieson, A., Nguyen, M., Rahman, A., English, C., Tincknell, L., Kakodkar, P., Kwek, I., Punjabi, N., Burns, J., Varghese, S., Erotocritou, M., Mcguckin, S., Vayalapra, S., Dominguez, E., Moneim, J., Bhatia, S., Kouli, O., Salehi, M., Tan, H. L., Yoong, A., Zhu, L., Seale, B., Nowinka, Z., Patel, N., Chrisp, B., Harris, J., Maleyko, I., Muneeb, F., Gough, M., James, C. E., Skan, O., Chowdhury, A., Rebuffa, N., Khan, H., Down, B., Fatimah, H. Q., Siaw-Acheampong, K., Benson, R. A., Bywater, E., Dawson, B. E., Evans, J. P., Heritage, E., Jones, C. S., Khatri, C., Keatley, J. M., Knight, A., Lawday, S., Mann, H. S., Marson, E. J., Mckay, S. C., Mills, E. C., Pellino, G., Picciochi, M., Taylor, E. H., Tiwari, A., Simoes, J. F. F., Trout, I. M., Venn, M. L., Wilkin, R. J. W., Smart, N. J., Minaya-Bravo, A., Gallo, G., Moug, S., Di Saverio, S., Vallance, A., Vimalchandran, D., Griffiths, E. A., Evans, R. P. T., Townend, P., Roberts, K., Mckay, S., Isaac, J., Satoi, S., Edwards, J., Coonar, A. S., Marchbank, A., Caruana, E. J., Layton, G. R., Patel, A., Brunelli, A., Ford, S., Desai, A., Gronchi, A., Fiore, M., Almond, M., Tirotta, F., Dumitra, S., Kolias, A., Price, S. J., Fountain, D. M., Jenkinson, M. D., Hutchinson, P., Marcus, H. J., Piper, R. J., Lippa, L., Servadei, F., Esene, I., Freyschlag, C., Neville, I., Rosseau, G., Schaller, K., Demetriades, A. K., Robertson, F., Alamri, A., Shaw, R., Schache, A. G., Winter, S. C., Ho, M., Nankivell, P., Biel, J. R., Batstone, M., Ganly, I., Vidya, R., Wilkins, A., Singh, J. K., Thekinkattil, D., Sundar, S., Fotopoulou, C., Leung, E., Khan, T., Chiva, L., Sehouli, J., Fagotti, A., Cohen, P., Gutelkin, M., Ghebre, R., Konney, T., Pareja, R., Bristow, R., Dowdy, S., Rajkumar, S. T. S., Ng, J., Fujiwara, K., Stewart, G. D., Lamb, B., Narahari, K., Mcneill, A., Colquhoun, A., Mcgrath, J., Bromage, S., Barod, R., Kasivisvanathan, V., Klatte, T., Abbott, T. E. F., Abukhalaf, S., Adamina, M., Ademuyiwa, A. O., Agarwal, A., Akkulak, M., Alderson, D., Alakaloko, F., Albertsmeiers, M., Alser, O., Alshaar, M., Alshryda, S., Arnaud, A. P., Augestad, K. M., Ayasra, F., Azevedo, J., Bankhead-Kendall, B. K., Barlow, E., Beard, D., Blanco-Colino, R., Brar, A., Breen, K. A., Bretherton, C., Buarque, I. L., Burke, J., Chaar, M., Chakrabortee, S., Christensen, P., Cox, D., Cukier, M., Cunha, M. F., Davidson, G. H., Dil, S., Drake, T. M., Edwards, J. G., Elhadi, M., Emile, S., Farik, S., Fitzgerald, E. J., Garmanova, T., Ghosh, D., Gomes, G. M. A., Grecinos, G., Grundl, M., Halkias, C., Hisham, I., Hutchinson, P. J., Hwang, S., Isik, A., Jonker, P., Kaafarani, H. M. A., Keller, D., Kruijff, S., Lawani, I., Lederhuber, H., Leventoglu, S., Litvin, A., Loehrer, A., Loffler, M. W., Lorena, M. A., Modolo, M. M., Major, P., Martin, J., Mashbari, H. N., Mazingi, D., Metallidis, S., Mohan, H. M., Moore, R., Moszkowicz, D., Ng-Kamstra, J. S., Maimbo, M., Negoi, I., Niquen, M., Ntirenganya, F., Olivos, M., Oussama, K., Outani, O., Parreno-Sacdalanm, M., Rivera, C. J. P., Pinkney, T. D., Van der Plas, W., Qureshi, A., Radenkovic, D., Rutegard, M., Segura-Sampedro, J. J., Santos, I., Schache, A., Schnitzbauer, A. A., Seyi-Olajide, J. O., Sharma, N., Shu, S., Soreide, K., Spinelli, A., Sund, M., Tabiri, S., Tsoulfas, G., Vimalachandran, D., Warren, O. J., Wedderburn, D., Wright, N., Allemand, C., Boccalatte, L., Figari, M., Lamm, M., Larranaga, J., Marchitelli, C., Noll, F., Odetto, D., Perrotta, M., Saadi, J., Zamora, L., Alurralde, C., Caram, E. L., Eskinazi, D., Mendoza, J. P., Usandivaras, M., Badra, R., Esteban, A., Garcia, J. S., Garcia, P. M., Gerchunoff, J. I., Lucchini, S. M., Nigra, M. A., Vargas, L., Hovhannisyan, T., Stepanyan, A., Gould, T., Gourlay, R., Griffiths, B., Gananadha, S., Mclaren, M., Cecire, J., Joshi, N., Salindera, S., Sutherland, A., Ahn, J. H., Charlton, G., Chen, S., Gauri, N., Hayhurst, R., Jang, S., Jia, F., Mulligan, C., Yang, W., Ye, G., Zhang, H., Ballal, M., Gibson, D., Hayne, D., Moss, J., Viswambaram, P., Vo, U. G., Bennetts, J., Bright, T., Brooke-Smith, M., Fong, R., Gricks, B., Lam, Y. H., Ong, B. S., Szpytma, M., Watson, D., Bagraith, K., Caird, S., Chan, E., Dawson, C., Ho, D., Jeyarajan, E., Jordan, S., Lim, A., Nolan, G. J., Oar, A., Parker, D., Puhalla, H., Quennell, A., Rutherford, L., Von Papen, M., Wullschleger, M., Blatt, A., Cope, D., Fenton, M., Gani, J., Lott, N., Shugg, N., Elliott, M., Phung, D., Phan, D., Townend, D., Bong, C., Gundara, J., Frankel, A., Bowman, S., Guerra, G. R., Bolt, J., Buddingh, K., Dudi-Venkata, N. N., Jog, S., Kroon, H. M., Sammour, T., Smith, R., Stranz, C., Lah, K., Mcgahan, W., Mitchell, D., Morton, A., Pearce, A., Roberts, M., Sheahan, G., Swinson, B., Alam, N., Banting, S., Chong, L., Choong, P., Clatworthy, S., Foley, D., Fox, A., Hii, M. W., Knowles, B., Mack, J., Read, M., Rowcroft, A., Ward, S., Wright, G., Lanner, M., Konigsrainer, I., Bauer, M., Kafka, M., Messner, F., Ofner, D., Tsibulak, I., Emmanuel, K., Grechenig, M., Gruber, R., Harald, M., Ohlberger, L., Presl, J., Wimmer, A., Namazov, I., Samadov, E., Barker, D., Boyce, R., Corbin, S., Doyle, A., Eastmond, A., Gill, R., Haynes, A., Millar, S., O'Shea, M., Padmore, G., Paquette, N., Phillips, E., St John, S., Walkes, K., Flamey, N., Pattyn, P., Oosterlinck, W., Van den Eynde, J., Van den Eynde, R., Gatti, A., Nardi, C., Oliva, R., De Cicco, R., Cecconello, I., Gregorio, P., Pontual, L. L., Ribeiro, J. U., Takeda, F., Terra, R. M., Sokolov, M., Kidane, B., Srinathan, S., Boutros, M., Caminsky, N., Ghitulescu, G., Jamjoum, G., Moon, J., Pelletier, J., Vanounou, T., Wong, S., Kouyoumdjian, A., Johnston, B., Russell, C., Demyttenaere, S., Garfinkle, R., Abou-Khalil, J., Nessim, C., Stevenson, J., Heredia, F., Almeciga, A., Fletcher, A., Merchan, A., Puentes, L. O., Mendoza, Q. J., Bacic, G., Karlovic, D., Krssul, D., Zelic, M., Luksic, I., Mamic, M., Bakmaz, B., Coza, I., Dijan, E., Katusic, Z., Mihanovic, J., Rakvin, I., Frantzeskou, K., Gouvas, N., Kokkinos, G., Papatheodorou, P., Pozotou, I., Stavrinidou, O., Yiallourou, A., Martinek, L., Skrovina, M., Szubota, I., Zatecky, J., Javurkova, V., Klat, J., Avlund, T., Harbjerg, J. L., Iversen, L. H., Kjaer, D. W., Kristensen, H. O., Mekhael, M., Ebbehoj, A. L., Krarup, P., Schlesinger, N., Smith, H., Abdelsamed, A., Azzam, A. Y., Salem, H., Seleim, A., Abdelmajeed, A., Abdou, M., Abosamak, N. E., Al Sayed, M., Ashoush, F., Atta, R., Elazzazy, E., Elhoseiny, M., Elnemr, M., Elqasabi, M. S., Elsayed, H. M. E., Elsherbini, I., Essam, E., Eweda, M., Ghallab, I., Hassan, E., Ibrahim, M., Metwalli, M., Mourad, M., Qatora, M. S., Ragab, M., Sabry, A., Saifeldin, H., Saleh, M. M. E. M., Samih, A., Samir, A. A., Shehata, S., Shenit, K., Attia, D., Kamal, N., Osman, N., Abbas, A. M., Abd, E. H. A. S., Abdelkarem, M. M., Alaa, S., Ali, A. K., Ayman, A., Azizeldine, M. G., Elkhayat, H., Melghazaly, S., Monib, F. A., Nageh, M. A., Saad, M. M., Salah, M., Shahine, M., Yousof, E. A., Youssef, A., Eldaly, A., Elfiky, M., Nabil, A., Amira, G., Sallam, I., Sherief, M., Sherif, A., Abdelrahman, A., Aboulkassem, H., Ghaly, G., Hamdy, R., Morsi, A., Sherif, G., Abdeldayem, H., Abdelkader, S. I., Balabel, M., Fayed, Y., Sherif, A. E., Bekele, A., Kauppila, J., Sarjanoja, E., Helminen, O., Huhta, H., Kauppila, J. H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De Simone, B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., El amrani, M., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. R., Truant, S., Zerbib, P., Ballouhey, Q., Barrat, B., Laloze, J., Salle, H., Taibi, A., Usseglio, J., Bergeat, D., Merdrignac, A., Le Roy, B., Perotto, L. O., Scalabre, A., Aime, A., Ezanno, A., Malgras, B., Bouche, P., Tzedakis, S., Cotte, E., Glehen, O., Kepenekian, V., Lifante, J., Passot, G., D'Urso, A., Felli, E., Mutter, D., Pessaux, P., Seeliger, B., Bardet, J., Berry, R., Boddaert, G., Bonnet, S., Brian, E., Denet, C., Fuks, D., Gossot, D., Grigoroiu, M., Laforest, A., Levy-Zauberman, Y., Louis-Sylvestre, C., Moumen, A., Pourcher, G., Seguin-Givelet, A., Tribillon, E., Duchalais, E., Espitalier, F., Ferron, C., Malard, O., Bork, U., Distler, M., Fritzmann, J., Kirchberg, J., Praetorius, C., Riediger, C., Weitz, J., Welsch, T., Wimberger, P., Beyer, K., Kamphues, C., Lauscher, J., Loch, F. N., Schineis, C., Albertsmeier, M., Angele, M., Kappenberger, A., Niess, H., Schiergens, T., Werner, J., Becker, R., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Liokatis, P., Smolka, W., Nowak, K., Reinhard, T., Holzle, F., Modabber, A., Winnand, P., Knitschke, M., Kauffmann, P., Wolfer, S., Kleeff, J., Lorenz, K., Michalski, C., Ronellenfitsch, U., Schneider, R., Bertolani, E., Konigsrainer, A., Quante, M., Steidle, C., Uberruck, L., Yurttas, C., Betz, C. S., Bewarder, J., Bottcher, A., Burg, S., Busch, C., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Koenig, D., Moeckelmann, N., Nitschke, C., Priemel, M., Smeets, R., Speth, U., Thole, S., Uzunoglu, F. G., Vollkommer, T., Zeller, N., Battista, M. J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I., Diamantis, A., Gkrinia, E., Hajiioannou, J., Korais, C., Koukoura, O., Perivoliotis, K., Saratziotis, A., Skoulakis, C., Symeonidis, D., Tepetes, K., Tzovaras, G., Zacharoulis, D., Alexoudi, V., Antoniades, K., Astreidis, I., Christidis, P., Deligiannidis, D., Grivas, T., Ioannidis, O., Kalaitsidou, I., Loutzidou, L., Mantevas, A., Michailidou, D., Paraskevopoulos, K., Politis, S., Stavroglou, A., Tatsis, D., Tilaveridis, I., Vahtsevanos, K., Venetis, G., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Mpaili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Anthoulakis, C., Christou, C., Papadopoulos, V., Tooulias, A., Tsolakidis, D., Zouzoulas, D., Athanasakis, E., Chrysos, E., Tsiaoussis, J., Xenaki, S., Xynos, E., Futaba, K., Ho, M. F., Hon, S. F., Mak, T. W. C., Ng, S. S. M., Foo, C. C., Banky, B., Susztak, N., Aremu, M., Canas-Martinez, A., Cullivan, O., Murphy, C., Owens, P., Pickett, L., Akmenkalne, L., Byrne, J., Corrigan, M., Cullinane, C., Daly, A., Fleming, C., Jordan, P., Killeen, S., Lynch, N., Mccarthy, A., Mustafa, H., O'Brien, S., O'Leary, P., Syed, W. A. S., Vernon, L., Callanan, D., Huang, L., Ionescu, A., Sheahan, P., Balasubramanian, I., Boland, M., Conlon, K., Evoy, D., Fearon, N., Gallagher, T., Geraghty, J., Heneghan, H., Kennedy, N., Maguire, D., Mccartan, D., Mcdermott, E. W., Prichard, R. S., Winter, D., Alazawi, D., Barry, C., Boyle, T., Butt, W., Connolly, E. M., Donlon, N., Donohue, C., Fahey, B. A., Farrell, R., Fitzgerald, C., Kinsella, J., Larkin, J. O., Lennon, P., Maguire, P. J., Mccormick, P., Mehigan, B. J., Mohan, H., Nugent, T., O'Sullivan, H., Ravi, N., Reynolds, J. V., Rogers, A., Shokuhi, P., Smith, J., Smith, L. A., Timon, C., Bashir, Y., Bass, G., Connelly, T., Creavin, B., Earley, H., Elliott, J. A., Gillis, A., Kavanagh, D., Neary, P., O'Riordan, J., Reynolds, I. S., Rice, D., Ridgway, P., Umair, M., Whelan, M., Carroll, P., Collins, C., Corless, K., Finnegan, L., Fowler, A., Hogan, A., Kerin, M., Lowery, A., Mcanena, P., Mckevitt, K., Nizami, K., Ryan, E., Samy, A., Coffey, J. C., Cunningham, R., Devine, M., Nally, D., Peirce, C., Tormey, S., Hardy, N., O'Malley, S., Ryan, M., Macina, S., Mariani, N. M., Opocher, E., Pisani, C. A., Ferrari, F., Odicino, F., Sartori, E., Cotsoglou, C., Granieri, S., Bianco, F., Camillo, A., Colledan, M., Tornese, S., Zambelli, M. F., Bissolotti, G., Fusetti, S., Lemma, F., Marino, M. V., Mirabella, A., Vaccarella, G., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Tucci, R., Bassi, C., Bortolasi, L., Campagnaro, T., Casetti, L., De Pastena, M., Esposito, A., Fontana, M., Guglielmi, A., Landoni, L., Malleo, G., Marchegiani, G., Nobile, S., Paiella, S., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Salvia, R., Turri, G., Tuveri, M., Bellora, P., D'Aloisio, G., Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva, R. M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Ampollini, L., Bellanti, L., Bergonzani, M., Bertoli, G., Bocchialini, G., D'Angelo, G., Lanfranco, D., Musini, L., Poli, T., Santoro, G. P., Varazzani, A., Aguzzoli, L., Borgonovo, G., Castro, R. C., Coiro, S., Falco, G., Mandato, V. D., Mastrofilippo, V., Montella, M. T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone, F. N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Gasparini, Giulio, Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, Carlo, Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli, R. U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino, C. L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di barto-Lomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo, B. F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Donati, D., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi, K. M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, Y., Qasem, A., Abu Za'Nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel, A. 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K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli, A. S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De la Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy, M. S., Serevina, O. L., Smith, C., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter, R. M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram, V. G., Ang, K., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem, I. A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani, M. H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud, A. F., Mcpherson, I., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Mcdonald, C., Mcgrath, N., Mcsorley, N., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Lee, R. X. N., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Mcveigh, J., Myatt, R., Williams, M. A., Kaur, R., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Breik, O., Cato, L. D., Griffiths, E., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Mak, J. K. C., Martin, T., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Singh, J., Vijayan, D., Geddes, A., Mccaul, J., Mcmahon, J., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Mcdermott, F., Mclennan, A., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo, S. C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Smith, L., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Mcgregor, R., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Mckinney, R., Mcnicol, F., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Jayasinghe, J. D., Knowles, C., Kocher, H., Leal, S. I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Thaha, M., Thakur, B., Venn, M., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Durio, Y. H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Mcaleer, J., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Pickford, S., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. T., Karabatsou, K., Laurente, R., Pathmanaban, O., Al-Mukhtar, A., Giblin, A., Kelty, C., Lye, G., Newman, T., Sharkey, A., Steele, C., Sureshkumar, S. N., Whitehall, E., Athwal, R., Baker, A., Jones, L., Konstantinou, C., Ramcharan, S., Vatish, J., Wilkin, R., Ethunandan, M., Sekhon, G. K., Shields, H., Singh, R., Wensley, F., Lyons, A., Abbott, T., Anwar, S., Ghufoor, K., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Baker, C., Davies, A., Gossage, J., Kelly, M., Knight, W., Hall, J., Harris, G., James, G., Kang, C., Lin, D. J., Rajgor, A. D., Royle, T., Scurrah, R., Steel, B., Watson, L. J., Choi, D., Hutchison, R., Jain, A., Luoma, V., Marcus, H., May, R., Menon, A., Pramodana, B., Webber, L., Aneke, I. A., Asaad, P., Brown, B., Collis, J., Duff, S., Khan, A., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Babar, M. S., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Imam, S. M. B., Kapriniotis, K., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Mcewen, R., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Jones, S. E. F., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-Omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Mcevoy, K., Naredla, P., Robertson, S., Sait, M., Sarma, D. R., Shanbhag, S., Shortland, T., Simmonds, S., Skillman, J., Tewari, N., Walton, G., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. M., Sgro, A., Stewart, K. E., Turnbull, A., Aguilar, G. M., Talukder, S., Boyle, C., Fernando, D., Gallagher, K., Laird, A., Tham, D., Bath, M., Patki, P., Tanabalan, C., Arif, T., Magee, C., Nambirajan, T., Powell, S., Vinayagam, R., Flindall, I., Hanson, A., Mahendran, V., Green, S., Lim, M., Macdonald, L., Miu, V., Onos, L., Sheridan, K., Young, R., Alam, F., Griffiths, O., Houlden, C., Jones, R., Kolli, V. S., Lala, A. K., Leeson, S., Peevor, R., Seymour, Z., Chen, L., Henderson, E., Brown, K., Fleming, D., Heron, C., Hill, C., Kay, H., Leede, E., Mcelhinney, K., Olson, K., Osterberg, E. C., Riley, C., Srikanth, P., Thornhill, M., Blazer, D., Dilalla, G., Hwang, E. S., Lee, W., Lidsky, M., Plichta, J., Rosenberger, L., Scheri, R., Turnage, K., Visgauss, J., Zani, S., Farma, J., Clark, J., Kwon, D., Etchill, E., Gabre-Kidan, A., Jenny, H. E., Kent, A., Ladd, M., Long, C., Malapati, H., Margalit, A., Rapaport, S., Rose, J., Stevens, K., Tsai, L., Vervoort, D., Yesantharao, P., Dehal, A., Klaristenfeld, D., Huynh, K., Brown, L., Mullinax, J., Gusani, N., Hazelton, J., Maines, J., Oh, J. S., Ssentongo, A., Ssentongo, P., Azam, M., Choudhry, A., Marx, W., Fleming, J., Fuson, A., Gigliotti, J., Ovaitt, A., Ying, Y., Abel, M. K., Andaya, V., Bigay, K., Boeck, M. A., Chern, H., Corvera, C., El-Sayed, I., Glencer, A., Ha, P., Hamilton, B. C. S., Heaton, C., Hirose, K., Jablons, D. M., Kirkwood, K., Kornblith, L. Z., Kratz, J. R., Lee, R., Miller, P. N., Nakakura, E., Nunez-Garcia, B., O'Donnell, R., Ozgediz, D., Park, P., Robinson, B., Sarin, A., Sheu, B., Varma, M., Wai, K., Wustrack, R., Xu, M. J., Beswick, D., Goddard, J., Manor, J., Song, J., Fullmer, T., Gaskill, C., Gross, N., Kiong, K., Roland, C. L., Zafar, S. N., Abdallah, M., Abouassi, A., Almasri, M., Kulkarni, G., Marwan, H., Mehdi, M., Aoun, S., Ban, V. S., Batjer, H. H., Caruso, J., Abbott, D., Acher, A., Aiken, T., Barrett, J., Foley, E., Schwartz, P., Hawkins, A., Maiga, A., Laufer, J., Scasso, S., Adams, M., Bailey, A., Cullen, G., Fu, Y. X. J., Mcclement, B., Taylor, A., Aitken, S., Bachelet, B., de Gersigny, J. B., Chang, C., Khehra, B., Lahoud, N., Lee, S. M., Louca, M., Rozenbroek, P., Rozitis, E., Agbinya, N., Anderson, E., Arwi, G., Barry, I., Batchelor, C., Chong, T., Choo, L. Y., Clark, L., Daniels, M., Goh, J., Handa, A., Hanna, J., Huynh, L., Jeon, A., Kanbour, A., Lee, A., Lee, J., Lee, T., Leigh, J., Ly, D., Mcgregor, F., Nejatian, M., O'Loughlin, E., Ramos, I., Sanchez, B., Shrivathsa, A., Sincari, A., Sobhi, S., Swart, R., Trimboli, J., Wignall, P., Bourke, E., Chong, A., Clayton, S., Dawson, A., Hardy, E., Iqbal, R., Le, L., Mao, S., Marinelli, I., Metcalfe, H., Panicker, D., Ridgway, S., Tan, H. H., Thong, S., Van, M., Woon, S., Woon-Shoo-Tong, X. S., Yu, S., Ali, K., Chee, J., Chiu, C., Chow, Y. W., Duller, A., Nagappan, P., Ng, S., Selvanathan, M., Sheridan, C., Temple, M., Do, J. E., Humphries, E., Li, L., Mansour, L. T., Massy-Westropp, C., Fang, B., Farbood, K., Hong, H., Huang, Y., Joan, M., Koh, C., Liu, Y. H. A., Mahajan, T., Muller, E., Park, R., Tanudisastro, M., Wu, J. J. G., Chopra, P., Giang, S., Radcliffe, S., Thach, P., Wallace, D., Wilkes, A., Chinta, S. H., Li, J., Phan, J., Rahman, F., Segaran, A., Shannon, J., Zhang, M., Adams, N., Bonte, A., Colterjohn, N., Croyle, J. A., Donohue, J., Feighery, A., Keane, A., Mcnamara, D., Munir, K., Roche, D., Sabnani, R., Seligman, D., Sharma, S., Stickney, Z., Suchy, H., Tan, R., Yordi, S., Ahmed, I., Aranha, M., El Sabawy, D., Garwood, P., Harnett, M., Holohan, R., Howard, R., Kayyal, Y., Krakoski, N., Lupo, M., Mcgilberry, W., Nepon, H., Scoleri, Y., Urbina, C., Ahmad, F. M. F., Ahmed, O., Jaswantlal, D., Kelly, E., Khan, M. H. T., Naidu, D., Neo, W. X., Sugrue, M., Abbas, J. D., Abdul-Fattah, S., Azlan, A., Barry, K., Idris, N. S., Kaka, N., Mcdermott, D., Mohammad, N. M. N., Mozo, M., Rehal, A., Shaikh, Y. M., Wong, R. H., Curran, E., Gardner, M., Julka, R., Lasser, G., Ni, C. N., Ting, J., Browne, R., George, S., Janjua, Z., Leung, S. V., Megally, M., Ravenscroft, L., Vedadi, A., Vyas, V., Bryan, A., Sheikh, A., Ubhi, J., Vannelli, K., Vawda, A., Adeusi, L., Doherty, C., Gallagher, H., Gill, P., Hamza, H., Hogan, M., Kelly, S., Larry, J., Lynch, P., Mazeni, N. A., O'Connell, R., O'Loghlin, R., Singh, K., Abbas, S. R., Ali, A., Alkandari, B., Arnold, A., Arora, E., Azam, R., Breathnach, C., Cheema, J., Compton, M., Curran, S., Jayasamraj, O., Mohammed, N., Noone, A., Pal, A., Pandey, S., Quinn, P., Sheridan, R., Siew, L., Tan, E. P., Tio, S. W., Toh, V. T. R., Walsh, M., Yap, C., Yassa, J., Young, T., Agarwal, N., Almoosawy, S. A., Bowen, K., Bruce, D., Connachan, R., Cook, A., Daniell, A., Fung, H. K. F., Irving, A., Laurie, S., Lee, Y. J., Lim, Z. X., Maddineni, S., Mcclenaghan, R. E., Muthuganesan, V., Ravichandran, P., Roberts, N., Shaji, S., Solt, S., Toshney, E., Arnold, C., Belais, F., Bojanic, C., Chau, C. Y. C., De Soysa, S., Eldridge, M., Fairey, M., Fearnhead, N., Gueroult, A., Ho, J. S. Y., Joshi, K., Kadiyala, N., Khalid, S., Kumar, K., Lewis, E., Magee, J., Manetta-Jones, D., Mann, S., Mckeown, L., Mitrofan, C., Mohamed, T., Monnickendam, A., Ng, A. Y. K. C., Ortu, A., Pope, T., Pressling, S., Purohit, K., Saji, S., Shah, F. J., Shah, R., Siddiqui, S. S., Surman, K., Utukuri, M., Varghese, A., Williams, C. Y. K., Yang, J. J., Billson, E., Cheah, E., Holmes, P., Hussain, S., Murdock, D., Nicholls, A., Ramana, G., Saleki, M., Spence, H., Thomas, D., Yu, C., Abousamra, M., Brown, C., Conti, I., Donnelly, A., Durand, M., French, N., Goan, R., O'Kane, E., Rubinchik, P., Gardiner, H., Kempf, B., Lai, Y. L., Matthews, H., Minford, E., Rafferty, C., Reid, C., Sheridan, N., Al Bahri, T., Bhoombla, N., Rao, B. M., Titu, L., Chatha, S., Field, C., Gandhi, T., Gulati, R., Jha, R., Jones, S. M. T., Karim, S., Patel, R., Saunders, M., Sharma, K., Abid, S., Heath, E., Kurup, D., Cresswell, B., Felstead, D., Jennings, K., Kaluarachchi, T., Lazzereschi, L., Mayson, H., Miah, J. 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N., Risaliti, M., Sorbi, F., Taddei, A., Tucci, R., Bassi, C., Bortolasi, L., Campagnaro, T., Casetti, L., De Pastena, M., Esposito, A., Fontana, M., Guglielmi, A., Landoni, L., Malleo, G., Marchegiani, G., Nobile, S., Paiella, S., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Salvia, R., Turri, G., Tuveri, M., Bellora, P., D'Aloisio, G., Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva, R. M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Ampollini, L., Bellanti, L., Bergonzani, M., Bertoli, G., Bocchialini, G., D'Angelo, G., Lanfranco, D., Musini, L., Poli, T., Santoro, G. P., Varazzani, A., Aguzzoli, L., Borgonovo, G., Castro, R. C., Coiro, S., Falco, G., Mandato, V. D., Mastrofilippo, V., Montella, M. T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone, F. N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Capizzi, V., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Gasparini, Giulio, Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, Carlo, Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli, R. U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino, C. L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di barto-Lomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo, B. F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Donati, D., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi, K. M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, Y., Qasem, A., Abu Za'Nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel, A. S., Abdel, J. R., Abou, C. M. K., Al-Masri, M., Al-Najjar, H., Alawneh, F., Alsaraireh, O., Elayyan, M., Ghanem, R., Lataifeh, I., Alkadeeki, G. Z., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin, S. N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che, J. A., Hussain, A. H., Mohamed, S. A. S., Mohd, Y. M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De la Rosa Abaroa, M. A., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra, G. F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. A., Oropeza-Aguilar, M., Pena, G. P. E., Posadas-Trujillo, O. E., Rodriguez-Covarrubias, F., Salgado-Nesme, N., Vilatoba, M., Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M. Y., Derkaoui, H. -S. F., El abbadi, N., Amrani, L., Belkhadir, Z. H., Benkabbou, A., Chakib, O., El Ahmadi, B., El Bouazizi, Y., Essangri, H., Ghannam, A., Majbar, A. M., Mohsine, R., Souadka, A., Hompes, R., Meima-Van, P. E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Reijers, S., Van Houdt, W., Baaij, J., Bolster-Van, E. M., De Graaff, M., Sloothaak, D., Van Duijvendijk, P., Posma-Bouman, L., Derksen, T., Franken, J., Oosterling, S., De Bree, R., Konsten, J., Van Heinsbergen, M., Fidelis, L., Sholadoye, T. T., Tolani, M. A., Olaogun, J., Egbuchulem, I. K., Lawal, T. A., Ogundoyin, O., Olulana, D. I., Abdur-Rahman, L., Adeyeye, A., Aremu, I., Bello, J., Olasehinde, O., Popoola, A., Massoud, J., Massoud, R., Sorour, T. M., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees, A. R., Rai, L., Ayub, B., Hassan, N., Martins, R. S., Ramesh, P., Butt, U., Kashif, M., Khan, W. H., Umar, M., Waris, F. M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz, P. R., Vieira, B., Almeida, J. I., de Sa, T. C., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., da Silva, C. L., Lopes, L., Machado, N., Marialva, J., Nunes, C. M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athayde, N. R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., Costa, M., De Barros, J., De Oliveira Lopez, A. L., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Martins, R., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., da Costa, A. V., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes, M. M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., da Costa, A. G., Lobo, A. I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., dos Santos, G. M., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Soares, A., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Dias, B., Fazenda, A., Melo, N. J. P., Policarpo, F., da Novoa Gomes Miguel, I. I. S., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., de Barros, I. F., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira, N. I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre, P. A., Peralta, F. M., Ribeiro, J., Rio, R. L., Sousa, F. M., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira, P. L. A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., da Silva, A. A., Claro, M., Costa, S. D., Deus, A. C., Grilo, J. V., Borges, F., Corte, R. J., Henriques, S., Lima, M. J., Matos, C. P., da Silva, F. B., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins, J. D., Vieira, C. T., Messias, J., Millan, A., Salgado, I., Santos, P., Baia, C., Canotilho, R., Correia, A. M., Ferreira, P. A. P., Peyroteo, M., Videira, J. F., Escobar, P., Maldonado, S. M., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Ravakjd, F. F., Alshahrani, M., Alsharif, F., Eskander, M., Al Raddadi, R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Nasser, M., Said, B. A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M. I., Abdelrahman, S., Althobaiti, W., Al Habes, H., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes, G. D., Elawad, A., Alaamer, O., Alriyees, L., Alselaim, N., Abdulkareem, A., Ajlan, A., Akkour, K., Al-Habib, A., Al-Khayal, K., Alatar, A., Alburakan, A., Alhalal, H., Alhassan, B., Alhassan, N., Alobeed, O., Alsaif, A., Alsaif, F., Alshammari, S., Alshaygy, I., Barry, M., Bin, N. A., Bin, T. T., Bokhari, A., Elwatidy, S., Helmi, H., Madkhali, A., Nouh, T., Rabah, P. D., Zubaidi, A., Paunovic, I., Slijepcevic, N., Aleksic, L., Antic, A., Barisic, G., Ceranic, M., Galun, D., Grubac, Z., Jelenkovic, J., Kecmanovic, D., Kmezic, S., Knezevic, D., Krivokapic, Z., Latincic, S., Markovic, V., Matic, S., Miladinov, M., Pavlov, M., Pejovic, I., Tadic, B., Vasljevic, J., Velickovic, D., Zivanovic, M., Perovic, M., Srbinovic, L., Andrijasevic, S., Bozanovic, T., Cerovic, P. R., Dokic, M., Janjic, T., Jeremic, K., Kadija, S., Ladjevic, L. I., Mirkovic, L., Pantovic, S., Pilic, I., Radojevic, M., Stefanovic, A., Vidakovic, S., Vilendecic, Z., Antic, S., Dunderovic, D., Jelovac, D., Jezdic, Z., Konstantinovic, V., Kotlar, B., Kuzmanovic, C., Lazic, M., Petrovic, M., Popovic, F., Pucar, A., Romic, M., Sumrak, S., Vujanac, V., Bascarevic, V., Bogdanovic, I., Grujicic, D., Ilic, R., Milicevic, M., Milisavljevic, F., Miljkovic, A., Paunovic, A., Scepanovic, V., Stanimirovic, A., Todorovic, M., Jotic, A., Milovanovic, J., Trivic, A., Bumbasirevic, U., Dzamic, Z., Kajmakovic, B., Prijovic, N., Zivkovic, M., Buta, M., Cvetkovic, A., Djurisic, I., Gacic, S., Goran, M., Inic, Z., Jeftic, N., Jevric, M., Jokic, V., Markovic, I., Milanovic, M., Nikolic, S., Pejnovic, L., Savkovic, N., Spurnic, I., Stevic, D., Stojiljkovic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Milutinovic, V., Chan, C. W., Lieske, B., Galis, B., Simko, K., Almgla, N., Bernon, M., Boutall, A., Cairncross, L., Herman, A., Hilton, T., Jonas, E., Kloppers, C., Malherbe, F., Mugla, W., Nel, D., Rayamajhi, S., Van Wyngaard, T., Vogel, J., Castano-Leon, A. M., Delgado, F. J., Eiriz, F. C., Espino, S. -I. M., Esteban, S. O., Garcia, P. D., Gomez, P., Jimenez-Roldan, L., Lagares, A., Moreno-Gomez, L., Paredes, I., Perez, N. A., Sanchez, A. G., Santas, M., Fernandez, R. P., Paniagua, G. S. M., Sanchez-Santos, R., Vigorita, V., Acrich, E., Baena, S. E., Barrios, O., Golda, T., Santanach, C., Serrano-Navidad, M., Sorribas, G. M., Vives, R. V., Escola, D., Jimenez, A., Cayetano, P. L., Gomez, F. L., Artigues, E., Bernal-Sprekelsen, J. C., Catala, B. J. C., Collera, P., Del Gobbo, R. D., Farre, F. R., Flores, C. R., Gomez, D. C. J., Guardia, N., Guariglia, C. A., Osorio, A., Sanchez, J. R., Sanchon, L., Soto, M. C., Albi, M. B., Garcia, V. J. E., Alonso-Lamberti, L., Assaf, M., Baeza, P. N., Carabias, A., Garcia-Quijada, J., Huertas, F. M. A., Jimenez, M. J., Jimenez, V., Jover, J. M., Landeo, A. S. A., Leon, R., Martin, S. M. B., Perez, S. V., Ponce, S., Rodriguez, J. L., Salazar, A., Valle, R. A., Aguado, H., Aldecoa, A. I., Bravo, I. R., De Lacy, F. B., Di Somma, A., Diaz-Feijoo, B., Ensenat, N. J., Fabregas, N., Ferres, A., Gil, I. B., Gonzalez, S. J. J., Gracia, I., Hoyos, C. J. A., Lacy, A. M., Langdon, C., Momblan, D., Morales, X., Oleaga, L., Otero, A., Pedrosa, L., Poblete, C. J., Reyes, F. L. A., Roldan, R. P., Rumia-Arboix, J., Tercero-Uribe, A. I., Topczewski, T. E., Torales, J., Torne, A., Torne, R., Turrado-Rodriguez, V., Valero, R., Valverde, S., Anula, R., Cano-Valderrama, O., Del Campo Martin, M., Diez-Valladares, L., Dominguez, I., Dziakova, J., Garcia, A. M., Garcia, R. E., Gomez, L. L., Muguerza, J. M., Pizarro, M. J., Saez, C. P., del Pueblo, C. S., Sanchez-Pernaute, A., Sanz, O. G., Sanz-Lopez, R., Torres, A., Garces-Albir, M., Lopez, F., Martin-Arevalo, J., Moro-Valdezate, D., Pla-Marti, V., de Heredia, J. B., De Andres Asenjo, B., Gomez, S. T., Jezieniecki, C., Del Barrio, H. N., de Solorzano Aurusa, F. J. O., de Diego, A. R., Ruiz, S. M., Trujillo, D. J., Vazquez, F. A., Lora-Cumplido, P., Sosa, M. V., Gonzalez-Gonzalez, E., Minaya, B. A. M., de la Fuente, N. A., Cazador, L. M., Cecchini, L., Espinosa, C. A., Jimenez, T. M., Lopez, C. A., Mancebo, G., Martorell, P., Munarriz, M., Grau-Talens, E. J., Martin-Perez, B., Benavides, B. J. A., Carrasco, P. M., Fernandez, P. V., Fernandez-Lopez, A., Garcia, E. D., Garcia, P. V. J., Garcia, S. V., Gimenez, F. C., Gonzalez, V. F. M., Gurrea, E., Lopez-Morales, P., Marco, G. A., Martinez, A. J. A., Medina, E., Munoz, C. J. M., Parra, B. P. A., Pena, R. E., Ramirez, F. M., Ruiz-Marin, M., Sanchez, R. C., Valero, S. M., Estaire, G. M., Fernandez, C. A., Garcia, S. E. P., Jimenez, H. E., Martinez-Pinedo, C., Munoz-Atienza, V., Padilla-Valverde, D., Picon, R. R., Redondo, C. F. J., Sanchez-Garcia, S., Sanchez-Pelaez, D., Colombari, R. C., Del valle, E., Fernandez, M., Lozano, L. P., Rey, V. C., Steiner, M. A., Tudela, M., Zorrilla, O. J., Alcaide, M. F., Garcia, P. J. M., Troncoso, P. P., Mora-Guzman, I., Abellan, M., Achalandabaso, B. M., Jorba, R., Memba, I. R., Olona, C., Sales, M. R., Cavalle, B. P., Gavalda, P. M. G. P., Salinas, P. J., Aragon, A. E. J., Barbier, L., Caja, V. P., Gainza, A., Garcia, G. J. J., Mallabiabarrena, O. G., Marin, H., Martin, P. P., Melchor, C. I., Prieto, C. M., Rodriguez, F. A., Villalabeitia, A. I., De Andres Olabarria, U., Duran, B. M., Fernandez, P. F. J., Ibanez-Aguirre, F. J., Sanz, L. A., Ugarte-Sierra, B., De la Hoz Rodriguez, A., Di Martino, M., Garcia, S. J., Martin-Perez, E., de Nova, J. L. M., Calvo, E. P., Guillamot, R. P., Colao, G. L., Diaz, P. D., Esteban, A. E., Galindo, J. P., Gutierrez, S. M., Hernandez, B. M. A., Serrano, G. J., Alonso, P. A., Dieguez, B., Garcia-Conde, M., Hernandez-Garcia, M., Losada, M., Chiesa-Estomba, C. M., Gonzalez, G. J. A., Larruscain, E., Sistiaga-Suarez, J. A., Alvarez, E., Chavarrias, N., Frias, L., Garcia, P. V., Gegundez, S. A., Gortazar, S., Gracia, M., Guevara, J., Hernandez, G. A., Loayza, A., Maria, D. D. T., Marti, C., Melendez, M., Moreno-Palacios, E., Perez, Y., Prieto, N. M. I., Ramos-Martin, P., Rubio-Perez, I., Saavedra, J., Sanchez-Mendez, J. I., Siegrist, R. J., Urbieta, A., Zapardiel, I., Diaz, M. C., De Miguel Ardevines, M. D. C., Duque-Mallen, V., Gascon, F. I., Gonzalez-Nicolas, T. M. T., Gracia-Roche, C., Herrero, L. M., Jariod, F. U. M., Lanzon, A., Martinez, G. A., Matute, M., Redondo, C., Sanchez, F. N., Sanchez-Rubio, M., Santero-Ramirez, M. S., Saudi, S., Simon, S. M. V., Uson-Bouthelier, T., Blazquez, M. A., Diez, A. M., Garcia-Loarte, G. E., Garcia-Moreno, N. F., Gutierrez, C. A., Hernandez, P., Lasa, I., Mendoza-Moreno, F., Morales, P. N., Ovejero, M. E., Vera, M. C., Acebes, G. F., Bailon, M., Bueno, C. A. D., Choolani, B. E., Marcos-Santos, P., Miguel, T., Pacheco, S. D., Perez-Saborido, B., Sanchez, G. J., Tejero-Pintor, F. J., Alconchel, F., Conesa, A., Gil, M. J., Gutierrez, F. A. I., Lopez, A. A., Nicolas-Lopez, T., Ramirez, R. P., Roca, C. M. J., Rodrigues, K., Ruiz, M. J. J., Soriano, A. I., Cano, A., Capitan-Morales, L., Cintas, C. J., Gomez-Rosado, J., Oliva, M. F., Perez, S. M. A., Rio, L. F. D., Torres, A. C., Valdes-Hernandez, J., Cholewa, H., Domingo, S., Frasson, M., Lago, V., Marina, M. T., Martinez, C. C., Sancho-Muriel, J., Landaluce-Olavarria, A., Lecumberri, D., Abad, G. A., Abad-Motos, A., Martinez-Hurtado, E., Ripolles-Melchor, J., Ruiz, E. A., Cuadrado-Garcia, A., Garcia-Sancho, T. L., Heras, A. J., Mate, P., Ortega, V. I., Picardo, A. L., Rojo, L. J. A., Sanchez, C. N. F., de Colsa, D. S., Anchuelo, L. J., Cagigas, F. C., Caina, R. R., Gomez, R. M., Hernanz, F., Jimeno, F. J., Martinez-Perez, P., Poch, C., Santarrufina, M. S., Valbuena, J. V., Moliner-Sanchez, C., Pingarron-Martin, L., Rey-Biel, J., Ruiz, M. I., Blas, L. J. L., Cros, B., Escartin, J., Garcia, E. J., Nogues, A., Talal, E. -A. I., Yanez, C., Cagigal, O. E. P., Cervera, I., Diaz, P. P., Elena, G. D. C. R., Enjuto, D., Fernandez, B. P., Garces, G. R., Gonzalez, J., Hernandez, I., Herrera-Merino, N., de Salas, M. M., Martinez, P. P., Perez, G. M., Ramos, B. A., Rodriguez, G. L., Bescos, C., Brana, I., Caimari, B., De Pablo Garcia-Cuenca, A., Duran-Valles, F., Espin-Basany, E., Lopez de Sagredo, J. G., Pamias, J., Prat, N., Pujol, P. R., Saez, B. M., Arulanantham, A., Bandara, G. B. K., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S., Srishankar, S., Ali, K. A. A., Elbe, P., Lindqvist, E. K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli, A. S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De la Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy, M. S., Serevina, O. L., Smith, C., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter, R. M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram, V. G., Ang, K., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem, I. A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani, M. H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud, A. F., Mcpherson, I., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Mcdonald, C., Mcgrath, N., Mcsorley, N., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Lee, R. X. N., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Mcveigh, J., Myatt, R., Williams, M. A., Kaur, R., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Breik, O., Cato, L. D., Griffiths, E., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Mak, J. K. C., Martin, T., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Singh, J., Vijayan, D., Geddes, A., Mccaul, J., Mcmahon, J., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Mcdermott, F., Mclennan, A., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo, S. C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Smith, L., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Mcgregor, R., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Mckinney, R., Mcnicol, F., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Jayasinghe, J. D., Knowles, C., Kocher, H., Leal, S. I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Thaha, M., Thakur, B., Venn, M., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Durio, Y. H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Mcaleer, J., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Pickford, S., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. T., Karabatsou, K., Laurente, R., Pathmanaban, O., Al-Mukhtar, A., Giblin, A., Kelty, C., Lye, G., Newman, T., Sharkey, A., Steele, C., Sureshkumar, S. N., Whitehall, E., Athwal, R., Baker, A., Jones, L., Konstantinou, C., Ramcharan, S., Vatish, J., Wilkin, R., Ethunandan, M., Sekhon, G. K., Shields, H., Singh, R., Wensley, F., Lyons, A., Abbott, T., Anwar, S., Ghufoor, K., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Baker, C., Davies, A., Gossage, J., Kelly, M., Knight, W., Hall, J., Harris, G., James, G., Kang, C., Lin, D. J., Rajgor, A. D., Royle, T., Scurrah, R., Steel, B., Watson, L. J., Choi, D., Hutchison, R., Jain, A., Luoma, V., Marcus, H., May, R., Menon, A., Pramodana, B., Webber, L., Aneke, I. A., Asaad, P., Brown, B., Collis, J., Duff, S., Khan, A., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Babar, M. S., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Imam, S. M. B., Kapriniotis, K., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Mcewen, R., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Jones, S. E. F., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-Omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Mcevoy, K., Naredla, P., Robertson, S., Sait, M., Sarma, D. R., Shanbhag, S., Shortland, T., Simmonds, S., Skillman, J., Tewari, N., Walton, G., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. M., Sgro, A., Stewart, K. E., Turnbull, A., Aguilar, G. M., Talukder, S., Boyle, C., Fernando, D., Gallagher, K., Laird, A., Tham, D., Bath, M., Patki, P., Tanabalan, C., Arif, T., Magee, C., Nambirajan, T., Powell, S., Vinayagam, R., Flindall, I., Hanson, A., Mahendran, V., Green, S., Lim, M., Macdonald, L., Miu, V., Onos, L., Sheridan, K., Young, R., Alam, F., Griffiths, O., Houlden, C., Jones, R., Kolli, V. S., Lala, A. K., Leeson, S., Peevor, R., Seymour, Z., Chen, L., Henderson, E., Brown, K., Fleming, D., Heron, C., Hill, C., Kay, H., Leede, E., Mcelhinney, K., Olson, K., Osterberg, E. C., Riley, C., Srikanth, P., Thornhill, M., Blazer, D., Dilalla, G., Hwang, E. S., Lee, W., Lidsky, M., Plichta, J., Rosenberger, L., Scheri, R., Turnage, K., Visgauss, J., Zani, S., Farma, J., Clark, J., Kwon, D., Etchill, E., Gabre-Kidan, A., Jenny, H. E., Kent, A., Ladd, M., Long, C., Malapati, H., Margalit, A., Rapaport, S., Rose, J., Stevens, K., Tsai, L., Vervoort, D., Yesantharao, P., Dehal, A., Klaristenfeld, D., Huynh, K., Brown, L., Mullinax, J., Gusani, N., Hazelton, J., Maines, J., Oh, J. S., Ssentongo, A., Ssentongo, P., Azam, M., Choudhry, A., Marx, W., Fleming, J., Fuson, A., Gigliotti, J., Ovaitt, A., Ying, Y., Abel, M. K., Andaya, V., Bigay, K., Boeck, M. A., Chern, H., Corvera, C., El-Sayed, I., Glencer, A., Ha, P., Hamilton, B. C. S., Heaton, C., Hirose, K., Jablons, D. 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A., Nair, G., Owusu-Ayim, M., Kanani, A., Kilkelly, B., Ogunmwonyi, I., Ong, L., Samra, B., Schomerus, L., Shea, J., Turner, O., Yang, Y., Amin, M., Blott, N., Clark, A., Feather, A., Forrest, M., Hague, S., Hamilton, K., Higginbotham, G., Hope, E., Karimian, S., Loveday, K., Malik, H., Mckenna, O., Noor, A., Onsiong, C., Patel, B., Radcliffe, N., Shah, P., Tye, L., Verma, K., Walford, R., Yusufi, U., Zachariah, M., Casey, A., Dore, C., Fludder, V., Fortescue, L., Kalapu, S. S., Karel, E., Khera, G., Appleton, B., Ashaye, A., Boggon, E., Evans, A., Faris, M. H., Hinchcliffe, Z., Marei, O., Silva, I., Spooner, C., Thomas, G., Timlin, M., Wellington, J., Yao, S. L., Abdelrazek, M., Abdelrazik, Y., Bee, F., Joseph, A., Mounce, A., Parry, G., Vignarajah, N., Biddles, D., Creissen, A., Kolhe, S., Lea, A., Ledda, V., O'Loughlin, P., Scanlon, J., Shetty, N., Weller, C., Adeoye, A., Bhatti, M., Chadda, K. R., Chu, J., Elhakim, H., Foster-Davies, H., Rabie, M., Tailor, B., Webb, S., Abdelrahim, A. S. A., Choo, S. Y., Jiwa, A., Mangam, S., Murray, S., Shandramohan, A., Aghanenu, O., Budd, W., Hayre, J., Khanom, S., Liew, Z. Y., Moody, N., Muhammad-Kamal, H., Odogwu, J., Patel, D., Sattar, Z., Shahrokhi, N., Sinha, I., Thomson, E., Wonga, L., Bain, J., Khan, J., Ricardo, D., Bevis, R., Cherry, C., Darkwa, S., Drew, W., Konda, N., Madani, D., Meda, B., Odunukwe, U., Preest, G., Raheel, F., Rajaseharan, A., Ramgopal, A., Risbrooke, C., Selvaratnam, K., Sethunath, G., Tabassum, R., Taylor, J., Thakker, A., Wijesingha, N., Wybrew, R., Yasin, T., Ahmed, O. A., Alfadhel, S., Carberry, E., Chen, J. Y., Drake, I., Glen, P., Jayasuriya, N., Kawar, L., Sinan, L. O. H., Siu, S. S. Y., Tjen, V., Adeboyejo, O., Bacon, H., Barnes, R., Birnie, C., D'Cunha, K. A., Hughes, E., Middleton, S., Owen, R., Schofield, E., Short, C., Wang, H., Willett, M., Zimmerman, M., Balfour, J., Chadwick, T., Coombe-Jones, M., Do Le, H. P., Hobson, K., Shehata, Z., Beattie, M., Chmielewski, G., Chong, C., Donnelly, B., Drusch, B., Ellis, J., Farrelly, C., Feyi-Waboso, J., Hibell, I., Hoade, L., Ho, C., Jones, H., Kodiatt, B., Lidder, P., Ni, C. L., Norman, R., Patabendi, I., Penfold, H., Playfair, M., Pomeroy, S., Ralph, C., Rottenburg, H., Sebastian, J., Sheehan, M., Stanley, V., Welchman, J., Ajdarpasic, D., Antypas, A., Azouaghe, O., Basi, S., Bettoli, G., Bhattarai, S., Bommireddy, L., Bourne, K., Budding, J., Cookey-Bresi, R., Cummins, T., Davies, G., Fabelurin, C., Gwilliam, R., Hanley, J., Hird, A., Kruczynska, A., Langhorne, B., Lund, J., Lutchman, I., Mcguinness, R., Neary, M., Pampapathi, S., Pang, E., Podbicanin, S., Rai, N., Redhouse, W. G., Sujith, J., Thomas, P., Walker, I., Winterton, R., Anderson, P., Barrington, M., Bhadra, K., Clark, G., Gibson, C., Hudson, S., Kaminskaite, V., Longshaw, A., Mackrill, E., Mclachlan, F., Murdeshwar, A., Nieuwoudt, R., Parker, P., Randall, R., Rawlins, E., Reeves, S. A., Rye, D., Sirkis, T., Sykes, B., Ventress, N., Wosinska, N., Akram, B., Burton, L., Coombs, A., Long, R., Ong, C., Sethi, M., Cambridge, W., Chan, L. H., Gaba, F., Khor, Z., Les, J. W., Mak, R., Moin, S., Ng, K. K. K. C., Paterson-Brown, S., Tew, Y. Y., Bardon, A., Burrell, K., Coldwell, C., Costa, I., Dexter, E., Hardy, A., Khojani, M., Mazurek, J., Reddy, V., Reynolds, J., Soma, A., Agiotakis, S., Alsusa, H., Desai, N., Peristerakis, I., Adcock, A., Ayub, H., Bennett, T., Bibi, F., Brenac, S., Chapman, T., Clarke, G., Clark, F., Galvin, C., Gwyn-Jones, A., Henry-Blake, C., Kerner, S., Kiandee, M., Lovett, A., Pilecka, A., Ravindran, R., Siddique, H., Sikand, T., Treadwell, K., Akmal, K., Apata, A., Barton, O., Broad, G., Darling, H., Dhuga, Y., Emms, L., Habib, S., Jain, R., Jeater, J., Kan, C. Y. P., Kathiravelupillai, A., Kirmani, S., Kulasabanathan, K., Lacey, H., Lal, K., Manafa, C., Mansoor, M., Mcdonald, S., Mittal, A., Mustoe, S., Nottrodt, L., Oliver, P., Papapetrou, I., Pattinson, F., Raja, M., Reyhani, H., Shahmiri, A., Small, O., Soni, U., Aguirrezabala, A. B., Bunni, J., Hakim, M. A., Hawkins-Hooker, L., Howell, K. A., Hullait, R., Jaskowska, A., Ottewell, L., Thomas-Jones, I., Vasudev, A., Clements, B., Fenton, J., Gill, M., Haider, S., Lim, A. J. M., Maguire, H., Mcmullan, J., Nicoletti, J., Samuel, S., Unais, M. A., White, N., Yao, P. C., Yow, L., Brady, R., Cheekoty, P., Cheong, J., Chew, S. J. H. L., Chow, R., Ganewatta, K. D., Mamer, L., Mohammed, B., Ng, C. H. J., Renji, C. R., Royston, A., Sharrad, E., Sinclair, R., Treherne, K., Wyatt, F., Maniarasu, V. S., Appanna, T., Bucknall, T., Hussain, F., Owen, A., Parry, R., Sagua, N., Spofforth, K., Yuen, E. C. T., Bosley, N., Hardie, W., Moore, T., Regas, C., Abdel-Khaleq, S., Ali, N., Bashiti, H., Buxton-Hopley, R., Constantinides, M., D'Afflitto, M., Deshpande, A., Duque, G. J., Frisira, E., Germani, B. M., Gomaa, A., Hay, D., Iakovou, A., Iakovou, D., Ismail, E., Jefferson, S., Khouli, Y., Mason, J., Mccaughan, R., Moffatt, J., Morawala, A., Nadir, H., Neyroud, F., Nikookam, Y., Parmar, A., Pinto, L., Richards, E., Thomson, S., Trainer, C., Valetopoulou, A., Vassiliou, A., Wantman, A., Wilde, S., Dickinson, M., Rockall, T., Senn, D., Wcislo, K., Zalmay, P., Adelekan, K., Allen, K., Bajaj, M., Gatumbu, P., Hang, S., Hashmi, Y., Kaur, T., Kawesha, A., Woodmass, M., Adelowo, T., Ahari, D., Alhwaishel, K., Clayton, B., Cockroft, A., Curtis, L. C., Hilton, M., Ismail, N., Kouadria, M., Lee, L., Macconnachie, A., Monks, F., Mungroo, S., Nikoletopoulou, C., Sara, X., Shahid, A., Suresh, G., Wilcha, R., Atiyah, A., Dermanis, A., Gibbons, H., Hyde, A., Lawson, A., Lee, C., Leung-Tack, M., Li, S. H. J., Mostafa, O., Nair, D., Pattani, N., Plumbley-Jones, J., Pufal, K., Sanghera, J., Saram, S., Scadding, S., See, S., Stringer, H., Torrance, A., Vardon, H., Wyn-Griffiths, F., Brew, A., Kaur, G., Soni, D., Tickle, A., Akbar, Z., Appleyard, T., Figg, K., Jayawardena, P., Johnson, A., Kamran, S. Z., Lacy-Colson, J., Oatham, R., Rowlands, B., Sludden, E., Turnbull, C., Allin, D., Ansar, Z., Azeez, Z., Dale, V. H., Garg, J., Horner, A., Jones, S., Knight, S., Mcgregor, C., Mckenna, J., Mclelland, T., Packham-Smith, A., Rowsell, K., Spector-Hill, I., Adeniken, E., Baker, J., Bartlett, M., Chikomba, L., Connell, B., Deekonda, P., Dhar, M., Elmansouri, A., Gamage, K., Goodhew, R., Hanna, P., Knight, J., Luca, A., Maasoumi, N., Mahamoud, F., Manji, S., Marwaha, P. K., Mason, F., Oluboyede, A., Pigott, L., Razaq, A. M., Richardson, M., Saddaoui, I., Wijeyendram, P., Yau, S., Atkins, W., Liang, K., Miles, N., Praveen, B., Ashai, S., Braganza, J., Common, J., Cundy, A., Davies, R., Guthrie, J., Handa, I., Iqbal, M., Ismail, R., Jones, C., Jones, I., Lee, K. S., Levene, A., Okocha, M., Smith, A., Subramaniam, E., Tandle, S., Wang, A., Watson, A., Wilson, C., Chan, X. H. F., Khoo, E., Montgomery, C., Norris, M., Pugalenthi, P. P., Common, T., Cook, E., Mistry, H., Shinmar, H. S., Agarwal, G., Bandyopadhyay, S., Brazier, B., Carroll, L., Goede, A., Harbourne, A., Lakhani, A., Larwood, J., Merchant, J., Pattenden, S., Pradhan, A., Raafat, N., Rothwell, E., Shammoon, Y., Sudarshan, R., Vickers, E., Wingfield, L., Ashworth, I., Azizi, S., Bhate, R., Chowdhury, T., Christou, A., Davies, L., Dwaraknath, M., Farah, Y., Garner, J., Gureviciute, E., Hart, E., Javid, S., Kankam, H. K., Kaur, T. P., Kaz, R., Kermali, M., Khan, I., Mattson, A., Mcmanus, A., Murphy, M., Nair, K., Ngemoh, D., Norton, E., Olabiran, A., Parry, L., Payne, T., Pillai, K., Punjabi, K., Raghunathan, A., Raza, M., Ritehnia, J., Simpson, G., Smith, W., Sodeinde, S., Studd, L., Subramaniam, M., Thomas, J., Towey, S., Tsang, E., Tuteja, D., Vasani, J., Vio, M., Badran, A., Adams, J., Anthony, W. J., Asvandi, S., Austin, T., Bald, A., Gasparini G. (ORCID:0000-0001-5091-5178), and Ratto C. (ORCID:0000-0002-0556-0037)

Abstract

Background: This study aimed to determine the impact of pulmonary complications on death after surgery both before and during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods: This was a patient-level, comparative analysis of two, international prospective cohort studies: one before the pandemic (January-October 2019) and the second during the SARS-CoV-2 pandemic (local emergence of COVID-19 up to 19 April 2020). Both included patients undergoing elective resection of an intra-abdominal cancer with curative intent across five surgical oncology disciplines. Patient selection and rates of 30-day postoperative pulmonary complications were compared. The primary outcome was 30-day postoperative mortality. Mediation analysis using a natural-effects model was used to estimate the proportion of deaths during the pandemic attributable to SARS-CoV-2 infection. Results: This study included 7402 patients from 50 countries; 3031 (40.9 per cent) underwent surgery before and 4371 (59.1 per cent) during the pandemic. Overall, 4.3 per cent (187 of 4371) developed postoperative SARS-CoV-2 in the pandemic cohort. The pulmonary complication rate was similar (7.1 per cent (216 of 3031) versus 6.3 per cent (274 of 4371); P = 0.158) but the mortality rate was significantly higher (0.7 per cent (20 of 3031) versus 2.0 per cent (87 of 4371); P < 0.001) among patients who had surgery during the pandemic. The adjusted odds of death were higher during than before the pandemic (odds ratio (OR) 2.72, 95 per cent c.i. 1.58 to 4.67; P < 0.001). In mediation analysis, 54.8 per cent of excess postoperative deaths during the pandemic were estimated to be attributable to SARS-CoV-2 (OR 1.73, 1.40 to 2.13; P < 0.001). Conclusion: Although providers may have selected patients with a lower risk profile for surgery during the pandemic, this did not mitigate the likelihood of death through SARS-CoV-2 infection. Care providers must act urgently to protect surgical

Published
2021

36. The Impact of the COVID-19 pandemic on people with diabetes and diabetes services : A pan-European survey of diabetes specialist nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium

Author

Forde, Rita, Arente, Liga, Ausili, Davide, De Backer, Kristin, Due-Christensen, Mette, Epps, Amanda, Fitzpatrick, Anne, Grixti, Moira, Groen, Sijda, Halkoaho, Arja, Huber, Claudia, Iversen, Marjolein M, Johansson, Unn-Britt, Leippert, Claudia, Ozcan, Seyda, Parker, Julie, Paiva, Ana Christina, Sanpetreanu, Adina, Savet, Marie-Alice, Rosana, Svetic-Cisic, Szewczyk, Alicja, Valverde, Maite, Vlachou, Eugenia, Forbes, Angus, Forde, Rita, Arente, Liga, Ausili, Davide, De Backer, Kristin, Due-Christensen, Mette, Epps, Amanda, Fitzpatrick, Anne, Grixti, Moira, Groen, Sijda, Halkoaho, Arja, Huber, Claudia, Iversen, Marjolein M, Johansson, Unn-Britt, Leippert, Claudia, Ozcan, Seyda, Parker, Julie, Paiva, Ana Christina, Sanpetreanu, Adina, Savet, Marie-Alice, Rosana, Svetic-Cisic, Szewczyk, Alicja, Valverde, Maite, Vlachou, Eugenia, and Forbes, Angus

Abstract

AIM: To describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe. METHODS: An online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks. RESULTS: Survey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n=504) and 48% (n=873) of diabetes nurses felt the COVID-19 pandemic had impacted 'a lot' on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased 'a lot': anxiety 82% (n=1486); diabetes distress 65% (n=1189); depression 49% (n= 893); acute hyperglycaemia 39% (n=710); and foot complications 17% (n=323). Forty-seven percent (n=771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n=499), 63% (n=1,027) and 34% (n=551), respectively. CONCLUSION: The findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population.

Published
2021
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37. A Bayesian meta-analysis on early tobacco exposure and vascular health: From childhood to early adulthood

Author

Biostatistiek Onderzoek, Circulatory Health, Georgiopoulos, Georgios, Oikonomou, Dimitrios, Pateras, Konstantinos, Masi, Stefano, Magkas, Nikolaos, Delialis, Dimitrios, Ajdini, Erold, Vlachou, Victoria, Stamatelopoulos, Kimon, Charakida, Marietta, Biostatistiek Onderzoek, Circulatory Health, Georgiopoulos, Georgios, Oikonomou, Dimitrios, Pateras, Konstantinos, Masi, Stefano, Magkas, Nikolaos, Delialis, Dimitrios, Ajdini, Erold, Vlachou, Victoria, Stamatelopoulos, Kimon, and Charakida, Marietta

Published
2021

38. A Stream Reasoning System for Maritime Monitoring

Author

Georgios M. Santipantakis and Akrivi Vlachou and Christos Doulkeridis and Alexander Artikis and Ioannis Kontopoulos and George A. Vouros, Santipantakis, Georgios M., Vlachou, Akrivi, Doulkeridis, Christos, Artikis, Alexander, Kontopoulos, Ioannis, Vouros, George A., Georgios M. Santipantakis and Akrivi Vlachou and Christos Doulkeridis and Alexander Artikis and Ioannis Kontopoulos and George A. Vouros, Santipantakis, Georgios M., Vlachou, Akrivi, Doulkeridis, Christos, Artikis, Alexander, Kontopoulos, Ioannis, and Vouros, George A.

Abstract

We present a stream reasoning system for monitoring vessel activity in large geographical areas. The system ingests a compressed vessel position stream, and performs online spatio-temporal link discovery to calculate proximity relations between vessels, and topological relations between vessel and static areas. Capitalizing on the discovered relations, a complex activity recognition engine, based on the Event Calculus, performs continuous pattern matching to detect various types of dangerous, suspicious and potentially illegal vessel activity. We evaluate the performance of the system by means of real datasets including kinematic messages from vessels, and demonstrate the effects of the highly efficient spatio-temporal link discovery on performance.

Published
2018
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39. An epigenetic map of malaria parasite development from host to vector

Author

Witmer, Kathrin, Fraschka, S.A.K., Vlachou, Dina, Bartfai, Richard, Christophides, George K., Witmer, Kathrin, Fraschka, S.A.K., Vlachou, Dina, Bartfai, Richard, and Christophides, George K.

Abstract

Contains fulltext : 224889.pdf (publisher's version ) (Open Access)

Published
2020

41. PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector

Author

Ukegbu, CV, Giorgalli, M, Tapanelli, S, Rona, LDP, Jaye, A, Wyer, C, Angrisano, F, Blagborough, AM, Christophides, GK, Vlachou, D, Ukegbu, CV, Giorgalli, M, Tapanelli, S, Rona, LDP, Jaye, A, Wyer, C, Angrisano, F, Blagborough, AM, Christophides, GK, and Vlachou, D

Abstract

After being ingested by a female Anopheles mosquito during a bloodmeal on an infected host, and before they can reach the mosquito salivary glands to be transmitted to a new host, Plasmodium parasites must establish an infection of the mosquito midgut in the form of oocysts. To achieve this, they must first survive a series of robust innate immune responses that take place prior to, during, and immediately after ookinete traversal of the midgut epithelium. Understanding how parasites may evade these responses could highlight new ways to block malaria transmission. We show that an ookinete and sporozoite surface protein designated as PIMMS43 (Plasmodium Infection of the Mosquito Midgut Screen 43) is required for parasite evasion of the Anopheles coluzzii complement-like response. Disruption of PIMMS43 in the rodent malaria parasite Plasmodium berghei triggers robust complement activation and ookinete elimination upon mosquito midgut traversal. Silencing components of the complement-like system through RNAi largely restores ookinete-to-oocyst transition but oocysts remain small in size and produce a very small number of sporozoites that additionally are not infectious, indicating that PIMMS43 is also essential for sporogonic development in the oocyst. Antibodies that bind PIMMS43 interfere with parasite immune evasion when ingested with the infectious blood meal and significantly reduce the prevalence and intensity of infection. PIMMS43 genetic structure across African Plasmodium falciparum populations indicates allelic adaptation to sympatric vector populations. These data add to our understanding of mosquito-parasite interactions and identify PIMMS43 as a target of malaria transmission blocking.

Published
2020

42. The development of consensus‐based guidelines for dietetic practice in nasogastric tube feeding under restraint for patients with anorexia nervosa using a modified Delphi process

Author

Fuller, SJ, Philpot, U, Barrett, N, Cooper, E, Doyle, M, Druce‐Perkins, J, Elliott, H, Falcoski, P, Forster, R, Hickley, Y, Jennings, R, Manson, D, Street, O, Vlachou, P, Wade, S, White, S, Fuller, SJ, Philpot, U, Barrett, N, Cooper, E, Doyle, M, Druce‐Perkins, J, Elliott, H, Falcoski, P, Forster, R, Hickley, Y, Jennings, R, Manson, D, Street, O, Vlachou, P, Wade, S, and White, S

Published
2020

44. The impact of the COVID-19 pandemic on people with diabetes and diabetes services: a pan-European survey of diabetes specialist nurses undertaken by the Foundation of European Nurses in Diabetes survey consortium

Author

Özcan, Hüsniye Şeyda (ORCID 0000-0003-0841-2563 & YÖK ID 108311), Forde, R.; Arente, L.; Ausili, D.; De Backer, K.; Due-Christensen, M.; Epps, A.; Fitzpatrick, A.; Grixti, M.; Groen, S.; Halkoaho, A.; Huber, C.; Iversen, M. M.; Johansson, U. B.; Leippert, C.; Parker, J.; Paiva, A. C.; Sanpetreanu, A.; Savet, M. A.; Rosana, S. C.; Szewczyk, A.; Valverde, M.; Vlachou, E.; Forbes, A.; the Fend Covid-19 consortium, School of Nursing, Özcan, Hüsniye Şeyda (ORCID 0000-0003-0841-2563 & YÖK ID 108311), Forde, R.; Arente, L.; Ausili, D.; De Backer, K.; Due-Christensen, M.; Epps, A.; Fitzpatrick, A.; Grixti, M.; Groen, S.; Halkoaho, A.; Huber, C.; Iversen, M. M.; Johansson, U. B.; Leippert, C.; Parker, J.; Paiva, A. C.; Sanpetreanu, A.; Savet, M. A.; Rosana, S. C.; Szewczyk, A.; Valverde, M.; Vlachou, E.; Forbes, A.; the Fend Covid-19 consortium, and School of Nursing

Abstract

Aim: to describe diabetes nurses' perspectives on the impact of the COVID-19 pandemic on people with diabetes and diabetes services across Europe. Methods: an online survey developed using a rapid Delphi method. The survey was translated into 17 different languages and disseminated electronically in 27 countries via national diabetes nurse networks. Results: survey responses from 1829 diabetes nurses were included in the analysis. The responses indicated that 28% (n = 504) and 48% (n = 873) of diabetes nurses felt the COVID-19 pandemic had impacted 'a lot' on the physical and psychological risks of people with diabetes, respectively. The following clinical problems were identified as having increased 'a lot': anxiety 82% (n = 1486); diabetes distress 65% (n = 1189); depression 49% (n = 893); acute hyperglycaemia 39% (n = 710) and foot complications 18% (n = 323). Forty-seven percent (n = 771) of respondents identified that the level of care provided to people with diabetes had declined either extremely or quite severely. Self-management support, diabetes education and psychological support were rated by diabetes nurse respondents as having declined extremely or quite severely during the COVID-19 pandemic by 31% (n = 499), 63% (n = 1,027) and 34% (n = 551), respectively. Conclusion: the findings show that diabetes nurses across Europe have seen significant increases in both physical and psychological problems in their patient populations during COVID-19. The data also show that clinical diabetes services have been significantly disrupted. As the COVID-19 situation continues, we need to adapt care systems with some urgency to minimise the impact of the pandemic on the diabetes population., Foundation of European Nurses in Diabetes

Published
2020

45. Probing the release of the chronobiotic hormone melatonin from hybrid calcium alginate hydrogel beads

Author

MARILENA VLACHOU, ANGELIKI SIAMIDI, EFSTRATIA GOULA, PANAGIOTIS GEORGAS, NATASSA PIPPA, VANGELIS KARALIS, THEODORE SENTOUKAS, STERGIOS PISPAS, MARILENA VLACHOU, ANGELIKI SIAMIDI, EFSTRATIA GOULA, PANAGIOTIS GEORGAS, NATASSA PIPPA, VANGELIS KARALIS, THEODORE SENTOUKAS, and STERGIOS PISPAS

Abstract

A variety of commonly used hydrogels were utilized in the preparation of calcium alginate beads, which incorporate the chronobiotic hormone melatonin (MLT). The in vitro release of the hormone in aqueous media at pH 1.2 and 6.8 was probed in the conjunction with the swelling of the beads and their thermal degradation properties. It has been found that the release of MLT from the beads was reversibly proportional to the extent of their expansion, which depends on the molecular mass/viscosity of the biopolymers present in the beads; the higher the molecular mass/viscosity of the hydrogels the greater the beads swelling and the less the MLT’s release. Thermogravimetric analysis (TGA) data support the presence of the components in the hybrid hydrogel beads and elucidate their effects on the thermal stability of the systems. Thus, the physicochemical properties of the biopolymers used, along with their stereoelectronic features modulate the release of MLT from the beads, providing formulations able to treat sleep onset related problems or dysfunctions arising from poor sleep maintenance.

Published
2020

46. Modified release of furosemide from Eudragits® and poly(ethylene oxide)-based matrices and dry-coated tablets

Author

MARILENA VLACHOU, EFTHYMIA GERANIOU, ANGELIKI SIAMIDI, MARILENA VLACHOU, EFTHYMIA GERANIOU, and ANGELIKI SIAMIDI

Abstract

Modified release of furosemide from tablet formulations is preferred by patients, because of physiological problems, acute diuresis being the most serious, compared to the forms designed for immediate release. With this in view, we aimed at achieving furosemide’s longer gastric retention and waste minimization by preparing matrix and compression coated tablets incorporating different grades of Eudragit® and poly(ethylene oxide) (PEO), polyvinylpyrrolidone (PVP) and lactose monohydrate. Dissolution profiles of the new formulations were compared with that of the main stream drug Lasix®, 40 mg tablets. The results indicate that the use of Eudragit® in conjunction with either PVP or lactose monohydrate led to a slower release rate in the intestinal fluids compared to Lasix®. Moreover, furosemide release in the intestinal pH from matrix tablets and compression coated tablets was not noticeably different. Formulations incorporating PEO led to sustained release, in intestinal fluids, which depended on the molecular weight of PEO.

Published
2020

50. Cutting-edge analytical technologies for the comprehensive metabolic profiling of Alkanna tinctoria roots cultured in greenhouse conditions

Author

UCL - SST/ELI - Earth and Life Institute, Rodić, N, Vlachou, A, Papakonstantinou, C, Zhao, Y, Cartabia, A, Lalaymia, I, Grigoriadou, K, Krigas, N, Maloupa, E, Declerck, S, Gika, HG, Papageorgiou, VP, Assimopoulou, AN, UCL - SST/ELI - Earth and Life Institute, Rodić, N, Vlachou, A, Papakonstantinou, C, Zhao, Y, Cartabia, A, Lalaymia, I, Grigoriadou, K, Krigas, N, Maloupa, E, Declerck, S, Gika, HG, Papageorgiou, VP, and Assimopoulou, AN

Abstract

The use of plants containing naphthoquinone derivatives Alkannins & Shikonins (A/S) by humans dates back to ancient times. In recent decades, the use of A/S has seen a resurgence and A/S have risen to a pivotal role as pharmaceutical and cosmeceutical agents, since they possess strong wound healing, antimicrobial, anti-inflammatory, tissue regenerative and antitumor properties. It is thus crucial to enhance the biosynthesis of bioactive A/S in Alkanna tinctoria plants, that naturally produce high amounts of these metabolites [1]. In the frame of “MICROMETABOLITE” EU H2020 project, we have optimized a workflow for the metabolic profiling of A. tinctoria roots, cultured in the greenhouse from plants obtained by in vivo shoot cuttings. A fast and reliable extraction procedure was achieved for comprehensive profiling and identification of A/S and other metabolites biosynthesized in the roots. The aim of this work was to determine the growth stage with peak A/S production, while simultaneously obtaining additional information on the root metabolome. A combination of UHPLC-HRMS and NMR was used for metabolite identification, HPLC was utilized for reliable quantitation of A/S and the extracts were subjected to chiral HPLC analysis [2] for determination of the enantiomeric A/S ratio. Different A/S derivatives and other metabolites were identified in plant roots using UHPLC-HRMS and NMR. Six A/S derivatives and total A/S were quantified using HPLC-DAD. From six vegetation stages of A. tinctoria grown under greenhouse conditions, fruiting period was found to peak A/S production (1% wt/wt of root), while the enantiomeric alkannin/shikonin ratio remained constant (93.7%).

Published
2019

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