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32 results on '"Visseren, F. L.J."'

1. LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients:A sex and gender-specific analysis

Author

Schreuder, M. M., Hamkour, S., Siegers, K. E., Holven, K. B., Johansen, A. K., van de Ree, M. A., Imholz, B., Boersma, E., Louters, L., Bogsrud, M. P., Retterstøl, K., Visseren, F. L.J., Roeters van Lennep, J. E., Koopal, C., Schreuder, M. M., Hamkour, S., Siegers, K. E., Holven, K. B., Johansen, A. K., van de Ree, M. A., Imholz, B., Boersma, E., Louters, L., Bogsrud, M. P., Retterstøl, K., Visseren, F. L.J., Roeters van Lennep, J. E., and Koopal, C.

Abstract

Background and aims: Despite lipid lowering therapy (LLT), reaching LDL-C targets in patients with familial hypercholesterolemia (FH) remains challenging. Our aim was to determine attainment of LDL-C target levels and reasons for not reaching these in female and male FH patients. Methods: We performed a cross-sectional study of heterozygous FH patients in five hospitals in the Netherlands and Norway. Clinical characteristics and information about LLT, lipid levels and reasons for not being on LDL-C treatment target were retrospectively collected from electronic medical records. Results: We studied 3178 FH patients (53.9% women), median age 48.0 (IQR 34.0–59.9) years. Median LDL-C before treatment and on-treatment was higher in women compared to men (6.2 (IQR 5.1–7.3) and 6.0 (IQR 4.9–7.2) mmol/l (p=0.005) and 3.0 (IQR 2.4–3.8) and 2.8 (IQR 2.3–3.5) mmol/L (p<0.001)), respectively. A minority of women (26.9%) and men (28.9%) reached LDL-C target. In patients with CVD, 17.2% of women and 25.8% of men reached LDL-C target. Women received less often high-intensity statins and ezetimibe. Most common reported reasons for not achieving the LDL-C target were insufficient effect of maximum LLT (women 17.3%, men 24.3%) and side effects (women 15.2%, men 8.6%). Conclusions: In routine practice, only a minority of women and men with FH achieved their LDL-C treatment target. Extra efforts have to be made to provide FH patients with reliable information on the safety of statins and their long-term effects on CVD risk reduction. If statin treatment is insufficient, alternative lipid lowering therapies such as ezetimibe or PCSK9-inhibitors should be considered.

Published
2023

2. LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients: A sex and gender-specific analysis

Author

Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Schreuder, M. M., Hamkour, S., Siegers, K. E., Holven, K. B., Johansen, A. K., van de Ree, M. A., Imholz, B., Boersma, E., Louters, L., Bogsrud, M. P., Retterstøl, K., Visseren, F. L.J., Roeters van Lennep, J. E., Koopal, C., Lab Reumatologie/Klinische Immunologie, Infection & Immunity, Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Schreuder, M. M., Hamkour, S., Siegers, K. E., Holven, K. B., Johansen, A. K., van de Ree, M. A., Imholz, B., Boersma, E., Louters, L., Bogsrud, M. P., Retterstøl, K., Visseren, F. L.J., Roeters van Lennep, J. E., and Koopal, C.

Published
2023

3. Effect of dietary patterns on cardiovascular risk factors in people with type 2 diabetes. A systematic review and network meta-analysis

Author

Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Bonekamp, N. E., van Damme, I., Geleijnse, J. M., Winkels, R. M., Visseren, F. L.J., Morris, P. B., Koopal, C., Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Bonekamp, N. E., van Damme, I., Geleijnse, J. M., Winkels, R. M., Visseren, F. L.J., Morris, P. B., and Koopal, C.

Published
2023

4. The challenge of choosing in cardiovascular risk management

Author

Hoogeveen, R. M., Hanssen, N. M.J., Brouwer, J. R., Mosterd, A., Tack, C. J., Kroon, A. A., de Borst, G. J., ten Berg, J., van Trier, T., van Lennep, J. Roeters, Liem, A., Serné, E., Visseren, F. L.J., Cornel, J. H., Peters, R. J.G., Jukema, J. W., Stroes, E. S.G., Hoogeveen, R. M., Hanssen, N. M.J., Brouwer, J. R., Mosterd, A., Tack, C. J., Kroon, A. A., de Borst, G. J., ten Berg, J., van Trier, T., van Lennep, J. Roeters, Liem, A., Serné, E., Visseren, F. L.J., Cornel, J. H., Peters, R. J.G., Jukema, J. W., and Stroes, E. S.G.

Abstract

Cardiovascular disease (CVD) is a major cause of morbidity and mortality worldwide. For many years guidelines have listed optimal preventive therapy. More recently, novel therapeutic options have broadened the options for state-of-the-art CV risk management (CVRM). In the majority of patients with CVD, risk lowering can be achieved by utilising standard preventive medication combined with lifestyle modifications. In a minority of patients, add-on therapies should be considered to further reduce the large residual CV risk. However, the choice of which drug combination to prescribe and in which patients has become increasingly complicated, and is dependent on both the absolute CV risk and the reason for the high risk. In this review, we discuss therapeutic decisions in CVRM, focusing on (1) the absolute CV risk of the patient and (2) the pros and cons of novel treatment options.

Published
2022

5. Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Author

MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L.J., MS Interne Geneeskunde, Circulatory Health, MS Radiologie, Arts-assistenten Radiologie, Beeldverwerking ISI, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Cancer, Researchgr. Systems Radiology, Infection & Immunity, Team Medisch, Zorgeenheid Vaatchirurgie Medisch, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 7a, Brain, MS Geriatrie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Interne Geneeskunde Vasculaire, Harlianto, Netanja I., Westerink, Jan, Hol, Marjolein E., Wittenberg, Rianne, Foppen, Wouter, Van Der Veen, Pieternella H., Van Ginneken, Bram, Verlaan, Jorrit Jan, De Jong, P. A., Mohamed Hoesein, Firdaus A.A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., and Visseren, F. L.J.

Published
2022

6. Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: Effectiveness and cost-effectiveness

Author

Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Interne Geneeskunde Vasculaire, MS Interne Geneeskunde, Circulatory Health, Cardiovasculaire Epi Team 5, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CCU Cardiologie, Team Medisch, HEE, Zorgeenheid Vaatchirurgie Medisch, Brain, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 7a, MS Geriatrie, Researchgr. Systems Radiology, Infection & Immunity, Cancer, MS Radiologie, MS Verloskunde, Child Health, CTC, Neurologen, Nefro Vasculaire Geneeskunde, Hageman, Steven H.J., Dorresteijn, Jannick A.N., Bots, Michiel L., Asselbergs, F. W., Westerink, Jan, Van Der Meulen, Miriam P., Mosterd, Arend, Visseren, F. L.J., Nathoe, H. M., De Borst, G. J., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., and Verhaar, M. C.

Published
2022

7. Detection of asymptomatic carotid stenosis in patients with lower-extremity arterial disease: Development and external validations of a risk score

Author

Zorgeenheid Vaatchirurgie Zorg, Opleiding Neurologie, Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Interne Geneeskunde Vasculaire, Poorthuis, M. H.F., Morris, D. R., De Borst, G. J., Bots, M. L., Greving, J. P., Visseren, F. L.J., Sherliker, P., Clack, R., Clarke, R., Lewington, S., Bulbulia, R., Halliday, A., Zorgeenheid Vaatchirurgie Zorg, Opleiding Neurologie, Zorgeenheid Vaatchirurgie Medisch, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 5, Interne Geneeskunde Vasculaire, Poorthuis, M. H.F., Morris, D. R., De Borst, G. J., Bots, M. L., Greving, J. P., Visseren, F. L.J., Sherliker, P., Clack, R., Clarke, R., Lewington, S., Bulbulia, R., and Halliday, A.

Published
2021

8. Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

Author

de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, on behalf of the SMART study group, de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, and on behalf of the SMART study group

Published
2019

9. Observational study of the medical management of patients with peripheral artery disease

Author

Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., Vascular and Endovascular Research Network (VERN) Collaborators, Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., and Vascular and Endovascular Research Network (VERN) Collaborators

Published
2019

11. Observational study of the medical management of patients with peripheral artery disease

Author

Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., Vascular and Endovascular Research Network (VERN) Collaborators, Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., and Vascular and Endovascular Research Network (VERN) Collaborators

Published
2019

12. Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

Author

de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, on behalf of the SMART study group, de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, and on behalf of the SMART study group

Published
2019

14. Observational study of the medical management of patients with peripheral artery disease

Author

Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., Vascular and Endovascular Research Network (VERN) Collaborators, Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., and Vascular and Endovascular Research Network (VERN) Collaborators

Published
2019

16. Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

Author

de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, on behalf of the SMART study group, de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, and on behalf of the SMART study group

Published
2019

17. Observational study of the medical management of patients with peripheral artery disease

Author

Interne Geneeskunde Vasculaire, Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., Vascular and Endovascular Research Network (VERN) Collaborators, Interne Geneeskunde Vasculaire, Saratzis, A., Jaspers, N. E.M., Gwilym, B., Thomas, O., Tsui, A., Lefroy, R., Parks, M., Htun, V., Mera, Z., Thatcher, A., Bosanquet, D., Forsythe, R., Benson, R., Dattani, N., Dovell, G., Lane, T., Shalhoub, J., Sidloff, D., Visseren, F. L.J., Dorresteijn, J. A.N., Richards, T., and Vascular and Endovascular Research Network (VERN) Collaborators

Published
2019

18. Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus

Author

Interne Geneeskunde Vasculaire, ZL Cerebrovasculaire Ziekten Medisch, Brain, Circulatory Health, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Verpleegafd Vaatchirurgie D4 Oost, Cardiovasculaire Immunologie, de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, On behalf of the SMART Study Group, Interne Geneeskunde Vasculaire, ZL Cerebrovasculaire Ziekten Medisch, Brain, Circulatory Health, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Verpleegafd Vaatchirurgie D4 Oost, Cardiovasculaire Immunologie, de Vries, T. I., Kappelle, L. J., van der Graaf, Y., de Valk, H. W., de Borst, G. J., Nathoe, H. M., Visseren, F. L.J., Westerink, Jan, and On behalf of the SMART Study Group

Published
2019

19. Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients

Author

Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 7, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Østergaard, H. B., Mandrup-Poulsen, T., Berkelmans, G. F.N., van der Graaf, Y., Visseren, F. L.J., Westerink, J., On behalf of the SMART Study Group, Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 7, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Østergaard, H. B., Mandrup-Poulsen, T., Berkelmans, G. F.N., van der Graaf, Y., Visseren, F. L.J., Westerink, J., and On behalf of the SMART Study Group

Published
2019

20. Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients

Author

Østergaard, H. B., Mandrup-Poulsen, T., Berkelmans, G. F.N., van der Graaf, Y., Visseren, F. L.J., Westerink, J., Østergaard, H. B., Mandrup-Poulsen, T., Berkelmans, G. F.N., van der Graaf, Y., Visseren, F. L.J., and Westerink, J.

Abstract

Background: The haemoglobin glycation index (HGI)has been proposed as a marker of interindividual differences in haemoglobin glycosylation. Previous studies have shown a relationship between high HGI and risk of cardiovascular disease (CVD)in patients with diabetes. However, no studies have investigated the role of previous CVD in this association. Methods: The study cohort comprised patients with type 2 diabetes mellitus (T2DM; n = 1910)included in the Second Manifestations of Arterial Disease (SMART)study. The relationship between either HGI or HbA1c and a composite of cardiovascular events as the primary outcome, and mortality, cardiovascular mortality, myocardial infarction and stroke as secondary outcomes, was investigated using Cox proportional-hazards models. Similar analyses were performed after stratification according to previous CVD. Results: A 1-unit higher HGI was associated with a 29% greater risk of a composite of cardiovascular events (HR: 1.29, 95% CI: 1.06–1.57)in patients without previous CVD, whereas no such relationship was seen in patients with previous CVD (HR: 0.96, 95% CI: 0.86–1.08). The direction and magnitude of the hazard ratios (HRs)of HGI and HbA1c in relation to outcomes were similar. Additional adjustment for HbA1c in the association between HGI and outcomes lowered the HRs. Conclusion: Similar to HbA1c, higher HGI is related to higher risk of cardiovascular events in patients with T2DM without CVD. As HbA1c has proved to be a comparable risk factor, and obtaining and interpreting the HGI is complicated, any additional benefit of applying the HGI in clinical settings is likely to be limited.

Published
2019

24. Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients

Author

Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Sharif, S., Bots, M. L., Schalkwijk, C., Stehouwer, C. D.A., Visseren, F. L.J., Westerink, J., SMART Study Group, Interne Geneeskunde Vasculaire, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Sharif, S., Bots, M. L., Schalkwijk, C., Stehouwer, C. D.A., Visseren, F. L.J., Westerink, J., and SMART Study Group

Published
2018

32. Relation between adiposity and vascular events, malignancy and mortality in patients with stable cerebrovascular disease

Author

UMC Utrecht, Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, ZL Cerebrovasculaire Ziekten Medisch, Brain, Planningssecretariaat HCK, Team Medisch, Jaspers, N. E.M., Dorresteijn, J. A.N., Van Der Graaf, Y., Westerink, J., Kappelle, L. J., Nathoe, H. M., Algra, A., Visseren, F. L.J., UMC Utrecht, Interne Geneeskunde Vasculaire, Circulatory Health, Unit Opleiding Aios, Cardiovasculaire Epi Team 7, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, ZL Cerebrovasculaire Ziekten Medisch, Brain, Planningssecretariaat HCK, Team Medisch, Jaspers, N. E.M., Dorresteijn, J. A.N., Van Der Graaf, Y., Westerink, J., Kappelle, L. J., Nathoe, H. M., Algra, A., and Visseren, F. L.J.

Published
2017

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