1. Benzimidazolyl quinolinyl mercaptotriazoles as potential antimicrobial and antiviral agents
- Author
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VINOD KUMAR PANDEY, MRIDULA UPADHYAY, MRINALINI UPADHYAY, VISHNU DEV GUPTA, MEENAL TANDON, VINOD KUMAR PANDEY, MRIDULA UPADHYAY, MRINALINI UPADHYAY, VISHNU DEV GUPTA, and MEENAL TANDON
- Abstract
Condensation of ethylaceto acetate (EAA) with resorcinol in concentrated H2SO4 afforded 7-hydroxy-4-methyl coumarin (1) which on reaction with thiosemicarbazide in anhydrous pyridine yielded 7-hydroxy-4-methyl-quinolinyl [1,5-c]-mercaptotriazole (2). Reaction of 2 with formaldehyde solution and amino acid in ethanol yielded 7-hydroxy-4-methyl-8-(N-methyl-aminoacid)-quinolinyl [1,5-c]-2"-mercaptotriazole (3). Interaction of 3 with o-phenylenediamine in pyridine yielded 7-hydroxy-4-methyl-8-(aminobenzimidazolyl)-quinolinyl [1,5-c]-2"-mercaptotriazole derivatives (4a-e). The latter compounds were evaluated for their antiviral and antimicrobial activities., Kondenzacijom etilacetoacetata (EAA) s rezorciolom u koncentriranoj H2SO4 dobiven je 7-hidroksi-4-metil kumarin (1) koji u reakciji s tiosemikarbazidom u bezvodnom piridinu daje 7-hidroksi-4-metil-kinolinil [1,5-c]-merkaptotriazol (2). Reakcijom spoja 2 s otopinom formaldehida i aminokiselinom u etanolu nastao je 7-hidroksi-4-metil-8-(N-metil-aminokiselina)-kinolinil [1,5-c]-2"-merkaptotriazol (3), koji je s o-fenilendiaminom u piridinu dao 7-hidroksi-4-metil-8-(aminobenzimidazolil)-kinolinil [1,5-c]-2''-merkaptotriazol derivate (4a-e). Ispitano je antivirusno i antimikrobno djelovanje spojeva 4.
- Published
- 2005