530 results on '"Vigano, A"'
Search Results
2. The interplay between mentalization, personality traits and burnout in psychiatry training: Results from a large multicenter controlled study
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Castellini, G, Tarchi, L, Cassioli, E, Ricca, V, Abbate Daga, G, Aguglia, A, Albert, U, Atti, A, Barlati, S, Blasi, G, Carmassi, C, Carra, G, De Fazio, P, De Panfilis, C, Di Lorenzo, G, Ferrari, S, Goracci, A, Gramaglia, C, Luciano, M, Martinotti, G, Menchetti, M, Menculini, G, Nanni, M, Nivoli, A, Pinna, F, Pompili, M, Rosso, G, Sambataro, F, Sampogna, G, Sani, G, Serafini, G, Signorelli, M, Tosato, S, Ventriglio, A, Vigano, C, Volpe, U, Fiorillo, A, Castellini G., Tarchi L., Cassioli E., Ricca V., Abbate Daga G., Aguglia A., Albert U., Atti A., Barlati S., Blasi G., Carmassi C., Carra G., De Fazio P., De Panfilis C., Di Lorenzo G., Ferrari S., Goracci A., Gramaglia C., Luciano M., Martinotti G., Menchetti M., Menculini G., Nanni M. G., Nivoli A., Pinna F., Pompili M., Rosso G., Sambataro F., Sampogna G., Sani G., Serafini G., Signorelli M. S., Tosato S., Ventriglio A., Vigano C., Volpe U., Fiorillo A., Castellini, G, Tarchi, L, Cassioli, E, Ricca, V, Abbate Daga, G, Aguglia, A, Albert, U, Atti, A, Barlati, S, Blasi, G, Carmassi, C, Carra, G, De Fazio, P, De Panfilis, C, Di Lorenzo, G, Ferrari, S, Goracci, A, Gramaglia, C, Luciano, M, Martinotti, G, Menchetti, M, Menculini, G, Nanni, M, Nivoli, A, Pinna, F, Pompili, M, Rosso, G, Sambataro, F, Sampogna, G, Sani, G, Serafini, G, Signorelli, M, Tosato, S, Ventriglio, A, Vigano, C, Volpe, U, Fiorillo, A, Castellini G., Tarchi L., Cassioli E., Ricca V., Abbate Daga G., Aguglia A., Albert U., Atti A., Barlati S., Blasi G., Carmassi C., Carra G., De Fazio P., De Panfilis C., Di Lorenzo G., Ferrari S., Goracci A., Gramaglia C., Luciano M., Martinotti G., Menchetti M., Menculini G., Nanni M. G., Nivoli A., Pinna F., Pompili M., Rosso G., Sambataro F., Sampogna G., Sani G., Serafini G., Signorelli M. S., Tosato S., Ventriglio A., Vigano C., Volpe U., and Fiorillo A.
- Abstract
Background: A better characterization of educational processes during psychiatry training is needed, both to foster personal resilience and occupational proficiency. Methods: An adequate coverage of medical residents at the national level was reached (41.86% of the total reference population, 29 out of 36 training centers—80.55%). Controls were recruited among residents in other medical specialties. All participants were assessed by questionnaires to evaluate early life experiences, attachment style, personality traits, coping strategies, emotional competencies. A Structural Equation Model (SEM) framework was employed to investigate the interplay between individual factors. Results: A total sample of 936 people was recruited (87.9% response-rate; 645 residents in psychiatry, 291 other medical residents). Psychiatry trainees reported a higher prevalence of adverse childhood experiences (emotional abuse, emotional neglect, physical neglect), greater attachment insecurity (anxious or avoidant) in comparison to other medical trainees. Psychiatry residents also reported higher social support-seeking as a coping strategy, lower problem-orientation, and lower transcendence. Lower neuroticism, higher openness to experience, and higher emotional awareness were also observed in psychiatry trainees. Psychiatry training was associated with a redefinition of conflict management skills as a function of seniority. The SEM model provided support for an interplay between early traumatic experiences, mentalization skills (coping strategies, emotion regulation), interpersonal competencies and occupational distress. Conclusions: The findings of the present study supported a theoretical model based on mentalization theory for the interactions between personal and relational competencies in psychiatry training, thus providing potential target of remodulation and redefinition of this specific process of education.
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- 2024
3. Bijective upsampling and learned embedding for point clouds correspondences
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Vigano', G, Melzi, S, Vigano', Giulio, Melzi, Simone, Vigano', G, Melzi, S, Vigano', Giulio, and Melzi, Simone
- Abstract
In this paper, we present a novel pipeline to compute and refine a data-driven solution for estimating the correspondence between 3D point clouds. Our method is compatible with the functional map framework, so it relies on a functional representation of the correspondence, but, differently from other similar approaches, this method is specifically designed to exploit this functional scenario for point cloud matching. Our new method merges a data-driven approach to compute functional basis and descriptors on the shape's surface and a new refinement method designed for the learned basis. This refinement algorithm arises from a different way of converting functional operators into point-to-point correspondence, which we prove to promote bijectivity between maps, exploiting a theoretical result. Iterating this procedure and performing basis upsampling in the same way as other similar methods, ours increases the accuracy of the correspondence, leading to more bijective correspondences. Different from other approaches, our method allows us to train a functional basis, considering the refinement stage. Combining our new pipeline with an improved feature extractor, our solution outperforms previous methods in various evaluations and settings. We test our method over different datasets, comprising near-isometric and non-isometric pairs
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- 2024
4. Textbook outcome in urgent early cholecystectomy for acute calculous cholecystitis: results post hoc of the S.P.Ri.M.A.C.C study
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Fugazzola, P, Carbonell-Morote, S, Cobianchi, L, Coccolini, F, Rubio-Garcia, J, Sartelli, M, Biffl, W, Catena, F, Ansaloni, L, Ramia, J, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Agnoletti, V, Bova, R, Convertini, G, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Ciof, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofa, S, Licari, L, Tomasoni, M, Dominioni, T, Fare, C, Maestri, M, Vigano, J, Sargenti, B, Anderloni, A, Musella, V, Frassini, S, Gambini, G, Improta, M, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Landaluce, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Ruta, F, Di Martino, M, Dal Mas, F, Abu-Zidan, F, Di Saverio, S, Leppaniemi, A, Martin-Perez, E, de la Hoz Rodriguez, A, Moore, E, Peitzman, A, Fugazzola P., Carbonell-Morote S., Cobianchi L., Coccolini F., Rubio-Garcia J. J., Sartelli M., Biffl W., Catena F., Ansaloni L., Ramia J. M., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Agnoletti V., Bova R., Convertini G., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Ciof S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofa S., Licari L., Tomasoni M., Dominioni T., Fare C. N., Maestri M., Vigano J., Sargenti B., Anderloni A., Musella V., Frassini S., Gambini G., Improta M., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Landaluce A., Estraviz-Mateos B., Markinez-Gordobil I., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Ruta F., Di Martino M., Dal Mas F., Abu-Zidan F. M., Di Saverio S., Leppaniemi A., Martin-Perez E., de la Hoz Rodriguez A., Moore E. E., Peitzman A. B., Fugazzola, P, Carbonell-Morote, S, Cobianchi, L, Coccolini, F, Rubio-Garcia, J, Sartelli, M, Biffl, W, Catena, F, Ansaloni, L, Ramia, J, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Agnoletti, V, Bova, R, Convertini, G, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Ciof, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofa, S, Licari, L, Tomasoni, M, Dominioni, T, Fare, C, Maestri, M, Vigano, J, Sargenti, B, Anderloni, A, Musella, V, Frassini, S, Gambini, G, Improta, M, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Landaluce, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Ruta, F, Di Martino, M, Dal Mas, F, Abu-Zidan, F, Di Saverio, S, Leppaniemi, A, Martin-Perez, E, de la Hoz Rodriguez, A, Moore, E, Peitzman, A, Fugazzola P., Carbonell-Morote S., Cobianchi L., Coccolini F., Rubio-Garcia J. J., Sartelli M., Biffl W., Catena F., Ansaloni L., Ramia J. M., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Agnoletti V., Bova R., Convertini G., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Ciof S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofa S., Licari L., Tomasoni M., Dominioni T., Fare C. N., Maestri M., Vigano J., Sargenti B., Anderloni A., Musella V., Frassini S., Gambini G., Improta M., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Landaluce A., Estraviz-Mateos B., Markinez-Gordobil I., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Ruta F., Di Martino M., Dal Mas F., Abu-Zidan F. M., Di Saverio S., Leppaniemi A., Martin-Perez E., de la Hoz Rodriguez A., Moore E. E., and Peitzman A. B.
- Abstract
Introduction: A textbook outcome patient is one in which the operative course passes uneventful, without complications, readmission or mortality. There is a lack of publications in terms of TO on acute cholecystitis. Objetive: The objective of this study is to analyze the achievement of TO in patients with urgent early cholecystectomy (UEC) for Acute Cholecystitis. and to identify which factors are related to achieving TO. Materials and methods: This is a post hoc study of the SPRiMACC study. It ́s a prospective multicenter observational study run by WSES. The criteria to define TO in urgent early cholecystectomy (TOUEC) were no 30-day mortality, no 30-day postoperative complications, no readmission within 30 days, and hospital stay ≤ 7 days (75th percentile), and full laparoscopic surgery. Patients who met all these conditions were taken as presenting a TOUEC. Outcomes: 1246 urgent early cholecystectomies for ACC were included. In all, 789 patients (63.3%) achieved all TOUEC parameters, while 457 (36.6%) failed to achieve one or more parameters and were considered non-TOUEC. The patients who achieved TOUEC were younger had significantly lower scores on all the risk scales analyzed. In the serological tests, TOUEC patients had lower values for in a lot of variables than non-TOUEC patients. The TOUEC group had lower rates of complicated cholecystitis. Considering operative time, a shorter duration was also associated with a higher probability of reaching TOUEC. Conclusion: Knowledge of the factors that influence the TOUEC can allow us to improve our results in terms of textbook outcome.
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- 2024
5. Lack of Seroconversion Following COVID-19 Vaccination Is an Independent Risk Factor for SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: Data from ESCAPE-IBD, an IG-IBD Study
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Macaluso, F, Principi, M, Facciotti, F, Contaldo, A, Todeschini, A, Saibeni, S, Bezzio, C, Castiglione, F, Nardone, O, Spagnuolo, R, Fantini, M, Riguccio, G, Conforti, S, Caprioli, F, Vigano, C, Felice, C, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Bossa, F, Guerra, M, Ventimiglia, M, Casa, A, Rizzo, G, Orlando, A, Amato, A, Ascolani, M, Calabrese, G, Comberlato, M, De Bona, M, Demarzo, M, Doldo, P, Dragoni, G, Furfaro, F, Laffusa, A, Martino, G, Mulinacci, G, Olmo, O, O'Sed, N, Paba, S, Radice, S, Renna, S, Ribaldone, D, MacAluso F. S., Principi M., Facciotti F., Contaldo A., Todeschini A., Saibeni S., Bezzio C., Castiglione F., Nardone O. M., Spagnuolo R., Fantini M. C., Riguccio G., Conforti S., Caprioli F., Vigano C., Felice C., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Bossa F., Guerra M., Ventimiglia M., Casa A., Rizzo G., Orlando A., Amato A., Ascolani M., Calabrese G., Comberlato M., De Bona M., Demarzo M. G., Doldo P., Dragoni G., Furfaro F., Laffusa A., Martino G., Mulinacci G., Olmo O., O'Sed N. P., Paba S., Radice S., Renna S., Ribaldone D. G., Macaluso, F, Principi, M, Facciotti, F, Contaldo, A, Todeschini, A, Saibeni, S, Bezzio, C, Castiglione, F, Nardone, O, Spagnuolo, R, Fantini, M, Riguccio, G, Conforti, S, Caprioli, F, Vigano, C, Felice, C, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Bossa, F, Guerra, M, Ventimiglia, M, Casa, A, Rizzo, G, Orlando, A, Amato, A, Ascolani, M, Calabrese, G, Comberlato, M, De Bona, M, Demarzo, M, Doldo, P, Dragoni, G, Furfaro, F, Laffusa, A, Martino, G, Mulinacci, G, Olmo, O, O'Sed, N, Paba, S, Radice, S, Renna, S, Ribaldone, D, MacAluso F. S., Principi M., Facciotti F., Contaldo A., Todeschini A., Saibeni S., Bezzio C., Castiglione F., Nardone O. M., Spagnuolo R., Fantini M. C., Riguccio G., Conforti S., Caprioli F., Vigano C., Felice C., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Bossa F., Guerra M., Ventimiglia M., Casa A., Rizzo G., Orlando A., Amato A., Ascolani M., Calabrese G., Comberlato M., De Bona M., Demarzo M. G., Doldo P., Dragoni G., Furfaro F., Laffusa A., Martino G., Mulinacci G., Olmo O., O'Sed N. P., Paba S., Radice S., Renna S., and Ribaldone D. G.
- Abstract
This prospective study reported 2 key results: (1) lack of seroconversion following 2 doses of COVID-19 vaccines is an independent predictor of SARS-CoV-2 infection; (2) treatments for IBD were not associated with increased risk of SARS-CoV-2 infection.
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- 2024
6. Formative assessment in Emergency Remote Teaching. Study of teachers’ beliefs and practices
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Minerva, Tommaso, De Santis, Annamaria, Giganti, Marco, Vigano', Renata Maria, Giganti, Marco (ORCID:0000-0002-3120-8344), Vigano, Renata Maria (ORCID:0000-0001-8739-7458), Minerva, Tommaso, De Santis, Annamaria, Giganti, Marco, Vigano', Renata Maria, Giganti, Marco (ORCID:0000-0002-3120-8344), and Vigano, Renata Maria (ORCID:0000-0001-8739-7458)
- Abstract
The contribution presents a multiple case study of three all-inclusive schools in Lombardy aimed at observing and describing their context, teachers’ beliefs, and practice statements about formative assessment, learning, and student engagement in the Emergency Remote Teaching activated during the critical period of the Covid-19 pandemic, and the relationship between them and the context. Specifically, the qualitative-quantitative analyses carried out on the results emerging from the semi-structured interviews conducted with Headmasters, document analysis (the three-year plan of educational offerings, self-evaluation report, circulars, policy acts etc.), the questionnaire submitted to teachers, and focus groups conducted with the HM, the internal evaluation team and selected teachers by school order will be presented. The case study is part of a larger research project of which hints will be provided in the presentation.
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- 2024
7. A cosa serve la ricerca educativa? Il dato e il suo valore sociale
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Vigano Renata (ORCID:0000-0001-8739-7458), Lisimberti Cristina (ORCID:0000-0003-3994-4095), Vigano', Renata Maria, Lisimberti, Cristina, Vigano Renata (ORCID:0000-0001-8739-7458), Lisimberti Cristina (ORCID:0000-0003-3994-4095), Vigano', Renata Maria, and Lisimberti, Cristina
- Abstract
Il volume raccoglie di atti del Convegno Nazionale della SIRD – Società Italiana per la Ricerca Didattica, tenutosi il 21 e 22 settembre 2023 presso la sede di Milano dell’Università Cattolica del Sacro Cuore sul tema “A cosa serve la ricerca educativa? Il dato e il suo valore sociale”. I contributi raccolti in questo volume, organizzati attorno a parole-chiave che identificano alcune questioni essenziali su cui la ricerca educativa si sviluppa (metodo; tecnologia; pratica; inclusione; valutazione), restituiscono la considerevole articolazione di contesti, aspetti, problemi che ne ricevono attenzione; è una ricchezza da valorizzare poiché aiuta a far crescere la consapevolezza che la dimensione e la ricerca educativa riguardano tutti i campi dell’esperienza e dell’esistenza.
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- 2024
8. 3D code for MAgneto-Thermal evolution in Isolated Neutron Stars, MATINS : thermal evolution and light curves
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Ascenzi, Stefano, Vigano, Daniele, Dehman, Clara, Pons, Jose A., Rea, Nanda, Perna, Rosalba, Ascenzi, Stefano, Vigano, Daniele, Dehman, Clara, Pons, Jose A., Rea, Nanda, and Perna, Rosalba
- Abstract
The thermal evolution of isolated neutron stars is a key element in unravelling their internal structure and composition and establishing evolutionary connections among different observational subclasses. Previous studies have predominantly focused on one-dimensional or axisymmetric two-dimensional models. In this study, we present the thermal evolution component of the novel three-dimensional magnetothermal code MATINS (MAgneto-Thermal evolution of Isolated Neutron Star). MATINS employs a finite volume scheme and integrates a realistic background structure, along with state-of-the-art microphysical calculations for the conductivities, neutrino emissivities, heat capacity, and superfluid gap models. This paper outlines the methodology employed to solve the thermal evolution equations in MATINS, along with the microphysical implementation that is essential for the thermal component. We test the accuracy of the code and present simulations with non-evolving magnetic fields of different configurations (all with electrical currents confined to the crust and a magnetic field that does not thread the core), to produce temperature maps of the neutron star surface. Additionally, for a specific magnetic field configuration, we show one fully coupled evolution of magnetic field and temperature. Subsequently, we use a ray-tracing code to link the neutron star surface temperature maps obtained by MATINS with the phase-resolved spectra and pulsed profiles that would be detected by distant observers. This study, together with our previous article focused on the magnetic formalism, presents in detail the most advanced evolutionary code for isolated neutron stars, with the aim of comparison with their timing properties, thermal luminosities and the associated X-ray light curves., QC 20240906
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- 2024
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9. Post-stroke acquired childhood aphasia. A scoping review
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Gilardone, G, Vigano, M, Cassinelli, D, Fumagalli, F, Calvo, I, Gilardone, M, Sozzi, M, Corbo, M, Gilardone G., Vigano M., Cassinelli D., Fumagalli F. M., Calvo I., Gilardone M., Sozzi M., Corbo M., Gilardone, G, Vigano, M, Cassinelli, D, Fumagalli, F, Calvo, I, Gilardone, M, Sozzi, M, Corbo, M, Gilardone G., Vigano M., Cassinelli D., Fumagalli F. M., Calvo I., Gilardone M., Sozzi M., and Corbo M.
- Abstract
Aphasia has a great impact on children’s lives, with stroke being its most common and studied etiology. However, our knowledge about this disorder is limited, the studies on this topic are sparse, and a consensus regarding its definition is lacking. In particular, the interpretation of this condition varied over time: from the rigid description of the so-called “standard doctrine” to the adoption of adult models for post-stroke aphasia. Therefore, this review provides a critical overview of childhood aphasia after stroke, focusing on its epidemiology, definition, diagnosis, and clinical manifestation. The scoping review approach was adopted, following PRISMA-ScR guidelines. PubMed, Web of Science, and PsycInfo databases were searched for related peer-review papers in English. Forty-six records were identified; the majority were single cases and case series, only a few were reviews and observational studies. Epidemiologic data are scarce; a few studies report that aphasia affects about one-third of children post-stroke. Despite terminological differences, there is an overall agreement on the definition of post-stroke aphasia in children as a language disorder acquired after the age of two. Approaches for the diagnosis and evaluation vary widely, including both assessments for developmental language disorders and tests for aphasia in adults. The clinical manifestations described in children are numerous and varied, similar to those found in adults, in contrast with the “standard doctrine.” This review highlights the need for further studies to improve the knowledge of this condition, develop validated and specific assessment tools, and standardize clinical management.
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- 2023
10. Profiling the risk of hepatocellular carcinoma after long-term HCV eradication in patients with liver cirrhosis in the PITER cohort
- Author
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Kondili, L, Quaranta, M, Cavalletto, L, Calvaruso, V, Ferrigno, L, D'Ambrosio, R, Simonelli, I, Brancaccio, G, Raimondo, G, Brunetto, M, Zignego, A, Coppola, C, Iannone, A, Biliotti, E, Verucchi, G, Massari, M, Licata, A, Barbaro, F, Persico, M, Russo, F, Morisco, F, Pompili, M, Vigano, M, Puoti, M, Santantonio, T, Villa, E, Craxi, A, Chemello, L, Panetta, V, Gaeta, G, Filomia, R, Coco, B, Monti, M, Amoruso, D, Madonia, S, Ieluzzi, D, Taliani, G, Badia, L, Migliorino, G, Giorgini, A, Masarone, M, Blanc, P, Cossiga, V, De Siena, M, Tata, X, Rumi, M, Chessa, L, Lampertico, P, Ferrari, C, Gentile, I, Parruti, G, Baiocchi, L, Ciancio, A, Invernizzi, P, Federico, A, Torti, C, Morsica, G, Andreone, P, Aghemo, A, Popoli, P, Vella, S, Kondili L. A., Quaranta M. G., Cavalletto L., Calvaruso V., Ferrigno L., D'Ambrosio R., Simonelli I., Brancaccio G., Raimondo G., Brunetto M. R., Zignego A. L., Coppola C., Iannone A., Biliotti E., Verucchi G., Massari M., Licata A., Barbaro F., Persico M., Russo F. P., Morisco F., Pompili M., Vigano M., Puoti M., Santantonio T., Villa E., Craxi A., Chemello L., Panetta V., Gaeta G. B., Filomia R., Coco B., Monti M., Amoruso D. C., Madonia S., Ieluzzi D., Taliani G., Badia L., Migliorino G. M., Giorgini A., Masarone M., Blanc P., Cossiga V., De Siena M., Tata X., Rumi M. G., Chessa L., Lampertico P., Ferrari C., Gentile I., Parruti G., Baiocchi L., Ciancio A., Invernizzi P., Federico A., Torti C., Morsica G., Andreone P., Aghemo A., Popoli P., Vella S., Kondili, L, Quaranta, M, Cavalletto, L, Calvaruso, V, Ferrigno, L, D'Ambrosio, R, Simonelli, I, Brancaccio, G, Raimondo, G, Brunetto, M, Zignego, A, Coppola, C, Iannone, A, Biliotti, E, Verucchi, G, Massari, M, Licata, A, Barbaro, F, Persico, M, Russo, F, Morisco, F, Pompili, M, Vigano, M, Puoti, M, Santantonio, T, Villa, E, Craxi, A, Chemello, L, Panetta, V, Gaeta, G, Filomia, R, Coco, B, Monti, M, Amoruso, D, Madonia, S, Ieluzzi, D, Taliani, G, Badia, L, Migliorino, G, Giorgini, A, Masarone, M, Blanc, P, Cossiga, V, De Siena, M, Tata, X, Rumi, M, Chessa, L, Lampertico, P, Ferrari, C, Gentile, I, Parruti, G, Baiocchi, L, Ciancio, A, Invernizzi, P, Federico, A, Torti, C, Morsica, G, Andreone, P, Aghemo, A, Popoli, P, Vella, S, Kondili L. A., Quaranta M. G., Cavalletto L., Calvaruso V., Ferrigno L., D'Ambrosio R., Simonelli I., Brancaccio G., Raimondo G., Brunetto M. R., Zignego A. L., Coppola C., Iannone A., Biliotti E., Verucchi G., Massari M., Licata A., Barbaro F., Persico M., Russo F. P., Morisco F., Pompili M., Vigano M., Puoti M., Santantonio T., Villa E., Craxi A., Chemello L., Panetta V., Gaeta G. B., Filomia R., Coco B., Monti M., Amoruso D. C., Madonia S., Ieluzzi D., Taliani G., Badia L., Migliorino G. M., Giorgini A., Masarone M., Blanc P., Cossiga V., De Siena M., Tata X., Rumi M. G., Chessa L., Lampertico P., Ferrari C., Gentile I., Parruti G., Baiocchi L., Ciancio A., Invernizzi P., Federico A., Torti C., Morsica G., Andreone P., Aghemo A., Popoli P., and Vella S.
- Abstract
Background and aims: Severe liver disease markers assessed before HCV eradication are acknowledged to usually improve after the SVR. We prospectively evaluated, in the PITER cohort, the long-term HCC risk profile based on predictors monitored after HCV eradication by direct-acting antivirals in patients with cirrhosis. Methods: HCC occurrence was evaluated by Kaplan-Meier analysis. Cox regression analysis identified the post-treatment variables associated with de-novo HCC; their predictive power was presented in a nomogram. Results: After the end of therapy (median follow-up:28.47 months), among 2064 SVR patients, 119 (5.8%) developed de-novo HCC. The HCC incidence was 1.90%, 4.21%, 6.47% at 12-, 24- and 36-months from end-of-therapy, respectively (incidence rate 2.45/100 person-years). Age, genotype 3, diabetes, platelets (PLT)≤120,000/µl and albumin ≤3.5g/dl levels were identified as pre-treatment HCC independent predictors. Adjusting for age, the post-treatment PLT≤120,000/µl (AdjHR 1.92; 95%CI:1.06-3.45) and albumin≤3.5g/dl (AdjHR 4.38; 95%CI 2.48-7.75) values were independently associated with HCC occurrence. Two different risk profiles were identified by combining long-term post-therapy evaluation of PLT ≤ vs. >120,000/µl and albumin ≤ vs. >3.5g/dl showing a significant different HCC incidence rate of 1.35 vs. 3.77/100 p-y, respectively. Conclusions: The nomogram score based on age, PLT and albumin levels after SVR showed an accurate prediction capability and may support the customizing management for early HCC detection.
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- 2023
11. Prefazione
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Gnocchi, R, Viganò, R, Vigano', Renata Maria, renata maria vigano (ORCID:0000-0001-8739-7458), Gnocchi, R, Viganò, R, Vigano', Renata Maria, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
Nell'orizzonte dei significati che attribuiamo alle parole spesso riscontriamo risvolti inattesi. Potenzialità, opportunità, limiti, rimandano a universi concettuali per i quali sembra assai naturale che il movimento pedaogico e i correlati pratici trovino in essi il loro luogo di esplicitazione per la realizzazione di interventi di natura preventiva o riparativa.
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- 2023
12. La professionalità pedagogica per i Servizi alla persona
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Gnocchi, R, Viganò, M, Vigano', Renata Maria, renata maria vigano (ORCID:0000-0001-8739-7458), Gnocchi, R, Viganò, M, Vigano', Renata Maria, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
Il senso di questa breve riflessione ruota attorno alla preposizione "per" posta nel titolo. Del resto, la struttura sintattica della frase è determinata proprio dalla preposizione che connette le due espressioni, cosicché i servizi alla persona assumono la funzione di complemento di vantaggio oppure - non abbiano un sussulto i linguisti - di complemento di causa. A ben vedere, entrambe le possibilità sussistono insieme; in ciò risiede lo snodo per entrare nel merito della questione situandola nell'orizzonte indicato dal tema del volume.
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- 2023
13. Safety, hesitancy of coronavirus disease 2019 vaccination and pandemic burden in patients with inflammatory bowel disease: Data of a national study (ESCAPE-IBD)
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Principi, M, Macaluso, F, Todeschini, A, Facciotti, F, Contaldo, A, Castiglione, F, Nardone, O, Spagnuolo, R, Doldo, P, Riguccio, G, Conforti, F, Vigano, C, Ascolani, M, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Caprioli, F, Mannino, M, Rizzo, G, Orlando, A, Principi M., Macaluso F. S., Todeschini A., Facciotti F., Contaldo A., Castiglione F., Nardone O. M., Spagnuolo R., Doldo P., Riguccio G., Conforti F. S., Vigano C., Ascolani M., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Caprioli F., Mannino M., Rizzo G., Orlando A., Principi, M, Macaluso, F, Todeschini, A, Facciotti, F, Contaldo, A, Castiglione, F, Nardone, O, Spagnuolo, R, Doldo, P, Riguccio, G, Conforti, F, Vigano, C, Ascolani, M, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Caprioli, F, Mannino, M, Rizzo, G, Orlando, A, Principi M., Macaluso F. S., Todeschini A., Facciotti F., Contaldo A., Castiglione F., Nardone O. M., Spagnuolo R., Doldo P., Riguccio G., Conforti F. S., Vigano C., Ascolani M., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Caprioli F., Mannino M., Rizzo G., and Orlando A.
- Abstract
Background and aims The purpose of this study was to present data on the safety of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in a cohort of inflammatory bowel disease (IBD) patients of an ongoing multicenter study (ESCAPE-IBD) sponsored by the Italian Group for the study of Inflammatory Bowel Disease (ClinicalTrials.gov Identifier: NCT04769258). Methods Anti-SARS-CoV-2 vaccination was administrated to 809 IBD patients. Interviews were conducted to report adverse events related to vaccination. Of these 809, 346 patients were surveyed on the pandemic burden and the main reason for hesitancy in coronavirus disease 2019 vaccination. The chi-square test was used to compare categorical variables. Logistic regression was used to assess the relationship between disease-related characteristics and the onset of adverse events. Results About 45% of patients had at least one side effect, following the first dose (10%), the second (15%), and both doses (19%). All the adverse events were mild and lasted only a few days. Logistic regression analysis revealed that female sex (P < 0.001), younger age (P = 0.001), seroconversion (P = 0.002), and comorbidity (P < 0.001) were significantly associated with adverse events. The survey showed that the main concerns were the possibility of adverse event (33%). Almost all patients (99%) felt safer having been vaccinated at their IBD reference center. Conclusion The vaccine reactions experienced in IBD patients were mostly self-limited. We found high acceptance and good safety of SARS-CoV-2 vaccination in our cohort.
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- 2023
14. Predicting home discharge after inpatient rehabilitation of stroke patients with aphasia
- Author
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Ginex, V, Vigano, M, Gilardone, G, Monti, A, Gilardone, M, Corbo, M, Ginex V., Vigano M., Gilardone G., Monti A., Gilardone M., Corbo M., Ginex, V, Vigano, M, Gilardone, G, Monti, A, Gilardone, M, Corbo, M, Ginex V., Vigano M., Gilardone G., Monti A., Gilardone M., and Corbo M.
- Abstract
The early identification of the discharge setting from Inpatient Rehabilitation Facilities is a primary goal in stroke-related research because of its clinical and socio-economic relevance. Several features have been identified as significant predictors of the discharge setting. Within cognitive deficits, aphasia is known to be a common and disabling condition that could influence rehabilitation outcome. However, it is often set as an exclusion criterion in stroke research. This study aims to investigate the predictive power of clinical variables, in particular specific language disturbances and nonlinguistic cognitive deficits, for discharge setting in post-acute stroke patients with aphasia after intensive multidisciplinary rehabilitation. In a sample of 158 patients, demographic, motor, language, and nonverbal cognitive data were retrospectively considered for the prediction of the discharge to home vs. another institutional setting. Univariate analysis identified relevant differences between groups and the significant variables were included in a logistic regression model. The results showed that better functional motor status, absence of dysphagia and unimpaired nonlinguistic cognitive profile independently predict the discharge to home. In particular, nonverbal cognitive functioning seemed to be specifically relevant within the aphasic population. The findings could be helpful for setting up the rehabilitation priorities and an adequate discharge arrangement.
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- 2023
15. Personalised management of patients with hepatocellular carcinoma: a multiparametric therapeutic hierarchy concept
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Vitale, A, Cabibbo, G, Iavarone, M, Vigano, L, Pinato, D, Ponziani, F, Lai, Q, Casadei-Gardini, A, Celsa, C, Galati, G, Gambato, M, Crocetti, L, Renzulli, M, Giannini, E, Farinati, F, Trevisani, F, Cillo, U, Baccarani, U, Brancaccio, G, Cozzolongo, R, Cucchetti, A, De Matthaeis, N, Di Sandro, S, Famularo, S, Finotti, M, Foschi, F, Ghinolfi, D, Guarracino, M, Gruttadauria, S, Guarino, M, Kostandini, A, Lenci, I, Levi Sandri, G, Manzia, T, Marasco, G, Masarone, M, Mazzarelli, C, Melandro, F, Miele, L, Morisco, F, Nicolini, D, Pagano, D, Pelizzaro, F, Pieri, G, Piscaglia, F, Plaz Torres, M, Pravisani, R, Rendina, M, Romano, F, Russo, F, Sacco, R, Sangiovanni, A, Sposito, C, Tortora, R, Tovoli, F, Vigano, M, Violi, P, Vitale A., Cabibbo G., Iavarone M., Vigano L., Pinato D. J., Ponziani F. R., Lai Q., Casadei-Gardini A., Celsa C., Galati G., Gambato M., Crocetti L., Renzulli M., Giannini E. G., Farinati F., Trevisani F., Cillo U., Baccarani U., Brancaccio G., Cozzolongo R., Cucchetti A., De Matthaeis N., Di Sandro S., Famularo S., Finotti M., Foschi F. G., Ghinolfi D., Guarracino M., Gruttadauria S., Guarino M., Kostandini A., Lenci I., Levi Sandri G. B., Manzia T. M., Marasco G., Masarone M., Mazzarelli C., Melandro F., Miele L., Morisco F., Nicolini D., Pagano D., Pelizzaro F., Pieri G., Piscaglia F., Plaz Torres M. C., Pravisani R., Rendina M., Romano F., Russo F. P., Sacco R., Sangiovanni A., Sposito C., Tortora R., Tovoli F., Vigano M., Violi P., Vitale, A, Cabibbo, G, Iavarone, M, Vigano, L, Pinato, D, Ponziani, F, Lai, Q, Casadei-Gardini, A, Celsa, C, Galati, G, Gambato, M, Crocetti, L, Renzulli, M, Giannini, E, Farinati, F, Trevisani, F, Cillo, U, Baccarani, U, Brancaccio, G, Cozzolongo, R, Cucchetti, A, De Matthaeis, N, Di Sandro, S, Famularo, S, Finotti, M, Foschi, F, Ghinolfi, D, Guarracino, M, Gruttadauria, S, Guarino, M, Kostandini, A, Lenci, I, Levi Sandri, G, Manzia, T, Marasco, G, Masarone, M, Mazzarelli, C, Melandro, F, Miele, L, Morisco, F, Nicolini, D, Pagano, D, Pelizzaro, F, Pieri, G, Piscaglia, F, Plaz Torres, M, Pravisani, R, Rendina, M, Romano, F, Russo, F, Sacco, R, Sangiovanni, A, Sposito, C, Tortora, R, Tovoli, F, Vigano, M, Violi, P, Vitale A., Cabibbo G., Iavarone M., Vigano L., Pinato D. J., Ponziani F. R., Lai Q., Casadei-Gardini A., Celsa C., Galati G., Gambato M., Crocetti L., Renzulli M., Giannini E. G., Farinati F., Trevisani F., Cillo U., Baccarani U., Brancaccio G., Cozzolongo R., Cucchetti A., De Matthaeis N., Di Sandro S., Famularo S., Finotti M., Foschi F. G., Ghinolfi D., Guarracino M., Gruttadauria S., Guarino M., Kostandini A., Lenci I., Levi Sandri G. B., Manzia T. M., Marasco G., Masarone M., Mazzarelli C., Melandro F., Miele L., Morisco F., Nicolini D., Pagano D., Pelizzaro F., Pieri G., Piscaglia F., Plaz Torres M. C., Pravisani R., Rendina M., Romano F., Russo F. P., Sacco R., Sangiovanni A., Sposito C., Tortora R., Tovoli F., Vigano M., and Violi P.
- Abstract
Advances in the surgical and systemic therapeutic landscape of hepatocellular carcinoma have increased the complexity of patient management. A dynamic adaptation of the available staging-based algorithms is required to allow flexible therapeutic allocation. In particular, real-world hepatocellular carcinoma management increasingly relies on factors independent of oncological staging, including patients’ frailty, comorbid burden, critical tumour location, multiple liver functional parameters, and specific technical contraindications impacting the delivery of treatment and resource availability. In this Policy Review we critically appraise how treatment allocation strictly based on pretreatment staging features has shifted towards a more personalised treatment approach, in which expert tumour boards assume a central role. We propose an evidence-based framework for hepatocellular carcinoma treatment based on the novel concept of multiparametric therapeutic hierarchy, in which different therapeutic options are ordered according to their survival benefit (ie, from surgery to systemic therapy). Moreover, we introduce the concept of converse therapeutic hierarchy, in which therapies are ordered according to their conversion abilities or adjuvant abilities (ie, from systemic therapy to surgery).
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- 2023
16. Integrated photocatalyst adsorbents based on silica/silicate-supported TiO2 for wastewater treatment
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Vigano', L, D’Arienzo, M, Mostoni, S, Nistico', R, Scotti, R, DI CREDICO, B, Lorenzo Vigano', Massimiliano D’Arienzo, Silvia Mostoni, Roberto Nistico', Roberto Scotti, Barbara Di Credico, Vigano', L, D’Arienzo, M, Mostoni, S, Nistico', R, Scotti, R, DI CREDICO, B, Lorenzo Vigano', Massimiliano D’Arienzo, Silvia Mostoni, Roberto Nistico', Roberto Scotti, and Barbara Di Credico
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- 2023
17. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons
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Siragusa, L, Angelico, R, Angrisani, M, Zampogna, B, Materazzo, M, Sorge, R, Giordano, L, Meniconi, R, Coppola, A, Marino, A, Giraudo, G, Esposito, S, Urbani, A, De Pastena, M, Mastrapasqua, R, Garancini, M, Frontal, A, Pascal, G, Martellucc, J, Falb, F, Boscarelli, A, Bertoglio, P, Trecca, E, Galassi, L, Vento, V, Chiappini, A, Antonelli, A, Bennardo, F, Familiari, F, Giannaccare, G, Zappia, A, Giuliani, G, Falcone, F, Sebastiani, S, Montuori, M, Rossi, S, Sagnotta, A, Giuliani, B, Imbriani, G, Restaino, S, Andreani, L, Di Maria, F, Lagana, A, Vitiello, L, Berton, F, Virgilio, E, Palisi, M, Portigliotti, L, Calussi, M, Conti, L, Mauriello, C, Barone, M, Saladino, E, Giaquinta, A, Zerb, D, Frazzetta, G, Merola, G, Chierici, A, Bini, R, Centonze, L, De Carlis, R, Ferrario, L, Giani, A, Lauterio, A, Tamini, N, Corti, S, Botteri, E, Andreuccetti, J, D'Alessio, R, Cestaro, G, Clarizia, G, Spolini, A, Carboni, A, Benzoni, E, Galiffa, G, Perotti, B, Veroux, M, Randazzo, V, Topa, D, Pranteda, C, Contini, G, Iacusso, C, Voglino, V, Vita, P, Carrano, F, Ambrosio, L, Cammarata, R, Capolupo, G, Caputo, D, Carannante, F, Cascone, C, Esperto, F, Farolfi, T, Frasca, L, Gallo, I, Gibin, G, Giurazza, G, Improta, L, La Vaccara, V, Luffarelli, P, Luvero, D, Marangi, G, Masciana, G, Mazzola, A, Mazzotta, E, Miligi, C, Montelione, N, Nenna, A, Orsaria, P, Papalia, R, Papalia, G, Parisi, F, Prata, F, Salzillo, R, Santini, S, Sofo, F, Zampoli, A, Tanda, C, Altieri, G, Ardito, F, Belia, F, Bianchi, V, Biondi, A, Brisinda, G, Chiappetta, M, Ciolli, G, Ciolli, A, Ferracci, F, Ferri, L, Fico, V, Fiorillo, C, Fransvea, P, Galiandro, F, Giovinazzo, F, La Greca, A, Litta, F, Mele, C, Pafundi, D, Panettieri, E, Papa, V, Patini, R, Perrotta, G, Puccioni, C, Santocchi, P, Armatura, G, Olmi, S, Casoni Pattacini, G, Salgarello, S, Trompetto, M, Bombardini, C, La Rocca, R, Celentano, G, Micalef, A, Mazzella, A, Settembrini, A, Zoia, C, Degrate, L, Musumeci, G, Palopoli, C, Montori, G, Bonati, E, Dinuzzi, V, Velluti, F, Balla, A, Bonasia, D, Coletta, D, Berardi, G, Colasanti, M, Ferretti, S, Gasparoli, C, Mariano, G, Avenia, S, Cianci, P, Cestino, L, Festa, F, Fazio, F, Ascari, F, Desio, M, Arroyo Murillo, G, Cereda, M, Galleano, R, David, G, Pansini, A, Gazia, C, Atzori, G, Desideri, L, Famularo, S, Galvanin, J, Giudici, V, Mangiameli, G, Mei, S, Milana, F, Pansa, A, Sacchi, M, Testori, A, Di Carlo, G, Paratore, M, Perrone, U, Vagge, A, Vigano, J, Torre, B, Scotti, M, Carbone, G, Cerchione, R, De Nardi, P, Gozzini, L, Ottaviani, L, Senni, C, Piccin, O, Pio, L, Colombo, F, Avantifiori, R, Baldassarri, V, Caronna, R, Cicerchia, P, Corallino, D, Crocetti, D, Gallo, G, Giovanardi, F, Giovannetti, F, Hassan, R, Iossa, A, Lai, Q, Lancellotti, F, Lucarini, A, Lucchese, S, Mazzarella, G, Melandro, F, Minervini, A, Muttillo, E, Palmieri, L, Pasqua, R, Rosiello, F, Salina, G, Sibio, S, Sirignano, P, Tarallo, M, Usai, S, Vanni, C, Viglietta, E, Zambon, M, Conversano, N, Epifani, A, Milano, V, Sacco, L, Nava, M, Maffioli, A, Giuratrabocchetta, S, Baracchi, F, Zuolo, M, Ceresoli, M, Verdi, D, Belli, A, Pata, F, Piovano, E, Pastore, G, Bernabei, F, Deiana, S, Arceri, A, D'Agostino, C, Marafante, C, Moggia, E, Parini, S, Moretti, M, Uggeri, F, Pontarolo, N, Fontana, T, Palmisano, G, Giuffrida, M, Guaitoli, E, Ferretti, C, Iacopino, G, Gioco, R, Roscitano, G, Montanelli, P, Pinotti, E, Monati, E, Fazio, G, Di Pietro, F, Damarco, F, Barberis, A, Razzore, A, Pascale, A, Loi, S, Ferrara, F, Rossi, M, Lisi, G, Viel, G, Sasia, D, Bono, D, Cordaro, E, Giacomelli, E, Giani, I, Seriau, L, Pellino, G, Sparavigna, M, Trigiante, G, D'Ambrogio, R, Cardella, F, Guzzetti, S, Luzzi, A, Carganico, G, Drago, B, Micheletto, G, Orlandi, R, Cutolo, C, Gibello, U, Mistrangelo, M, Forcignano, E, D'Ugo, S, Losurdo, P, Manitto, M, Caroli, G, Franco, M, Tilocca, P, Mendogni, P, Sena, G, Sambucci, D, Luciani, C, Atelli, P, Guida, A, Marino, F, Morini, A, Sibilla, M, Longo, F, Giaccari, S, Vigorita, V, Balduzzi, A, Barra, F, Delogu, D, Milone, E, Bencini, L, Aprile, V, Papini, P, Montemurro, N, Cavallo, M, Picciariello, A, Tomasicchio, G, Fittipaldi, A, Maruccia, M, Gerardi, S, Cillara, N, Deidda, S, Demarinis, G, Peiretti, E, Tatti, F, Iovino, C, Isola, G, Progno, V, Migliore, M, Badessi, G, Barilla, C, Calleri, G, Cianci, S, Fama, F, Fleres, F, Mazzeo, C, Visaloco, M, Marchetto, C, Bolognesi, F, Benuzzi, L, Bracchetti, G, Brucchi, F, Manzo, C, Scaravilli, L, Ferrari, C, Rocca, A, Napolitano, P, Anoldo, P, Caricato, C, Manigrasso, M, Milone, M, Napolitano, L, Palomba, G, Schiavone, V, Vetrella, M, Grossi, U, Moletta, L, Annicchiarico, A, Vella, I, Talesa, G, Boggi, U, Aiello, F, Anselmo, A, Bacchiocchi, G, Beati, F, Bellato, V, Billeci, F, Blasi, F, Buonomo, O, Campanelli, M, Coco, G, Contadini, A, Conte, L, D'Ippolito, G, Di Marcantonio, A, Spicchiale, C, Afflitto, G, Gismondi, A, Gorgolini, G, Granai, A, Grande, S, Gravina, A, Ingallinella, S, Keci, L, Latini, E, Marino, D, Oddi, F, Orecchia, L, Don, C, Pellicciaro, M, Petagna, L, Pirozzi, B, Quaranta, C, Rho, M, Rosina, A, Santicchia, M, Saraceno, F, Schiavone, A, Sensi, B, Spina, A, Sullo, L, Tacconi, F, Taje, R, Vanni, G, Vinci, D, Vita, G, Alba, G, Badalucco, S, Carbone, L, Samorani, O, Chisci, G, Cuomo, R, Francia, A, Fusario, D, Gargiulo, B, Pasqui, E, Pasquetti, L, Puoti, P, Resca, L, Cumbo, J, Ganio, S, Vizzielli, G, Anastasi, M, Guerra, D, Romanzi, A, Vannelli, A, Baia, M, Siragusa L., Angelico R., Angrisani M., Zampogna B., Materazzo M., Sorge R., Giordano L., Meniconi R., Coppola A., Marino A., Giraudo G., Esposito S., Urbani A., De Pastena M., Mastrapasqua R., Garancini M., Frontal A., Pascal G., Martellucc J., Falb F., Boscarelli A., Bertoglio P., Trecca E., Galassi L., Vento V., Chiappini A., Antonelli A., Bennardo F., Familiari F., Giannaccare G., Zappia A. S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., Baia M., Siragusa, L, Angelico, R, Angrisani, M, Zampogna, B, Materazzo, M, Sorge, R, Giordano, L, Meniconi, R, Coppola, A, Marino, A, Giraudo, G, Esposito, S, Urbani, A, De Pastena, M, Mastrapasqua, R, Garancini, M, Frontal, A, Pascal, G, Martellucc, J, Falb, F, Boscarelli, A, Bertoglio, P, Trecca, E, Galassi, L, Vento, V, Chiappini, A, Antonelli, A, Bennardo, F, Familiari, F, Giannaccare, G, Zappia, A, Giuliani, G, Falcone, F, Sebastiani, S, Montuori, M, Rossi, S, Sagnotta, A, Giuliani, B, Imbriani, G, Restaino, S, Andreani, L, Di Maria, F, Lagana, A, Vitiello, L, Berton, F, Virgilio, E, Palisi, M, Portigliotti, L, Calussi, M, Conti, L, Mauriello, C, Barone, M, Saladino, E, Giaquinta, A, Zerb, D, Frazzetta, G, Merola, G, Chierici, A, Bini, R, Centonze, L, De Carlis, R, Ferrario, L, Giani, A, Lauterio, A, Tamini, N, Corti, S, Botteri, E, Andreuccetti, J, D'Alessio, R, Cestaro, G, Clarizia, G, Spolini, A, Carboni, A, Benzoni, E, Galiffa, G, Perotti, B, Veroux, M, Randazzo, V, Topa, D, Pranteda, C, Contini, G, Iacusso, C, Voglino, V, Vita, P, Carrano, F, Ambrosio, L, Cammarata, R, Capolupo, G, Caputo, D, Carannante, F, Cascone, C, Esperto, F, Farolfi, T, Frasca, L, Gallo, I, Gibin, G, Giurazza, G, Improta, L, La Vaccara, V, Luffarelli, P, Luvero, D, Marangi, G, Masciana, G, Mazzola, A, Mazzotta, E, Miligi, C, Montelione, N, Nenna, A, Orsaria, P, Papalia, R, Papalia, G, Parisi, F, Prata, F, Salzillo, R, Santini, S, Sofo, F, Zampoli, A, Tanda, C, Altieri, G, Ardito, F, Belia, F, Bianchi, V, Biondi, A, Brisinda, G, Chiappetta, M, Ciolli, G, Ciolli, A, Ferracci, F, Ferri, L, Fico, V, Fiorillo, C, Fransvea, P, Galiandro, F, Giovinazzo, F, La Greca, A, Litta, F, Mele, C, Pafundi, D, Panettieri, E, Papa, V, Patini, R, Perrotta, G, Puccioni, C, Santocchi, P, Armatura, G, Olmi, S, Casoni Pattacini, G, Salgarello, S, Trompetto, M, Bombardini, C, La Rocca, R, Celentano, G, Micalef, A, Mazzella, A, Settembrini, A, Zoia, C, Degrate, L, Musumeci, G, Palopoli, C, Montori, G, Bonati, E, Dinuzzi, V, Velluti, F, Balla, A, Bonasia, D, Coletta, D, Berardi, G, Colasanti, M, Ferretti, S, Gasparoli, C, Mariano, G, Avenia, S, Cianci, P, Cestino, L, Festa, F, Fazio, F, Ascari, F, Desio, M, Arroyo Murillo, G, Cereda, M, Galleano, R, David, G, Pansini, A, Gazia, C, Atzori, G, Desideri, L, Famularo, S, Galvanin, J, Giudici, V, Mangiameli, G, Mei, S, Milana, F, Pansa, A, Sacchi, M, Testori, A, Di Carlo, G, Paratore, M, Perrone, U, Vagge, A, Vigano, J, Torre, B, Scotti, M, Carbone, G, Cerchione, R, De Nardi, P, Gozzini, L, Ottaviani, L, Senni, C, Piccin, O, Pio, L, Colombo, F, Avantifiori, R, Baldassarri, V, Caronna, R, Cicerchia, P, Corallino, D, Crocetti, D, Gallo, G, Giovanardi, F, Giovannetti, F, Hassan, R, Iossa, A, Lai, Q, Lancellotti, F, Lucarini, A, Lucchese, S, Mazzarella, G, Melandro, F, Minervini, A, Muttillo, E, Palmieri, L, Pasqua, R, Rosiello, F, Salina, G, Sibio, S, Sirignano, P, Tarallo, M, Usai, S, Vanni, C, Viglietta, E, Zambon, M, Conversano, N, Epifani, A, Milano, V, Sacco, L, Nava, M, Maffioli, A, Giuratrabocchetta, S, Baracchi, F, Zuolo, M, Ceresoli, M, Verdi, D, Belli, A, Pata, F, Piovano, E, Pastore, G, Bernabei, F, Deiana, S, Arceri, A, D'Agostino, C, Marafante, C, Moggia, E, Parini, S, Moretti, M, Uggeri, F, Pontarolo, N, Fontana, T, Palmisano, G, Giuffrida, M, Guaitoli, E, Ferretti, C, Iacopino, G, Gioco, R, Roscitano, G, Montanelli, P, Pinotti, E, Monati, E, Fazio, G, Di Pietro, F, Damarco, F, Barberis, A, Razzore, A, Pascale, A, Loi, S, Ferrara, F, Rossi, M, Lisi, G, Viel, G, Sasia, D, Bono, D, Cordaro, E, Giacomelli, E, Giani, I, Seriau, L, Pellino, G, Sparavigna, M, Trigiante, G, D'Ambrogio, R, Cardella, F, Guzzetti, S, Luzzi, A, Carganico, G, Drago, B, Micheletto, G, Orlandi, R, Cutolo, C, Gibello, U, Mistrangelo, M, Forcignano, E, D'Ugo, S, Losurdo, P, Manitto, M, Caroli, G, Franco, M, Tilocca, P, Mendogni, P, Sena, G, Sambucci, D, Luciani, C, Atelli, P, Guida, A, Marino, F, Morini, A, Sibilla, M, Longo, F, Giaccari, S, Vigorita, V, Balduzzi, A, Barra, F, Delogu, D, Milone, E, Bencini, L, Aprile, V, Papini, P, Montemurro, N, Cavallo, M, Picciariello, A, Tomasicchio, G, Fittipaldi, A, Maruccia, M, Gerardi, S, Cillara, N, Deidda, S, Demarinis, G, Peiretti, E, Tatti, F, Iovino, C, Isola, G, Progno, V, Migliore, M, Badessi, G, Barilla, C, Calleri, G, Cianci, S, Fama, F, Fleres, F, Mazzeo, C, Visaloco, M, Marchetto, C, Bolognesi, F, Benuzzi, L, Bracchetti, G, Brucchi, F, Manzo, C, Scaravilli, L, Ferrari, C, Rocca, A, Napolitano, P, Anoldo, P, Caricato, C, Manigrasso, M, Milone, M, Napolitano, L, Palomba, G, Schiavone, V, Vetrella, M, Grossi, U, Moletta, L, Annicchiarico, A, Vella, I, Talesa, G, Boggi, U, Aiello, F, Anselmo, A, Bacchiocchi, G, Beati, F, Bellato, V, Billeci, F, Blasi, F, Buonomo, O, Campanelli, M, Coco, G, Contadini, A, Conte, L, D'Ippolito, G, Di Marcantonio, A, Spicchiale, C, Afflitto, G, Gismondi, A, Gorgolini, G, Granai, A, Grande, S, Gravina, A, Ingallinella, S, Keci, L, Latini, E, Marino, D, Oddi, F, Orecchia, L, Don, C, Pellicciaro, M, Petagna, L, Pirozzi, B, Quaranta, C, Rho, M, Rosina, A, Santicchia, M, Saraceno, F, Schiavone, A, Sensi, B, Spina, A, Sullo, L, Tacconi, F, Taje, R, Vanni, G, Vinci, D, Vita, G, Alba, G, Badalucco, S, Carbone, L, Samorani, O, Chisci, G, Cuomo, R, Francia, A, Fusario, D, Gargiulo, B, Pasqui, E, Pasquetti, L, Puoti, P, Resca, L, Cumbo, J, Ganio, S, Vizzielli, G, Anastasi, M, Guerra, D, Romanzi, A, Vannelli, A, Baia, M, Siragusa L., Angelico R., Angrisani M., Zampogna B., Materazzo M., Sorge R., Giordano L., Meniconi R., Coppola A., Marino A., Giraudo G., Esposito S., Urbani A., De Pastena M., Mastrapasqua R., Garancini M., Frontal A., Pascal G., Martellucc J., Falb F., Boscarelli A., Bertoglio P., Trecca E., Galassi L., Vento V., Chiappini A., Antonelli A., Bennardo F., Familiari F., Giannaccare G., Zappia A. S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., and Baia M.
- Abstract
COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients’ management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons’ personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons’ perspective, COVID-related measures will continue to influence
- Published
- 2023
18. Prospective validation of the Israeli Score for the prediction of common bile duct stones in patients with acute calculous cholecystitis
- Author
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Fugazzola, P, Cobianchi, L, Dal Mas, F, Cicuttin, E, Dominioni, T, Frassini, S, Tomasoni, M, Vigano, J, Catena, F, Ansaloni, L, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Bova, R, Convertini, G, Agnoletti, V, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Cioffi, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofia, S, Licari, L, Anderloni, A, Maestri, M, Fare, C, Sargenti, B, Improta, M, Musella, V, Gambini, G, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Carbonell-Morote, S, Rubio-Garcia, J, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Landaluce-Olavarria, A, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Martin-Perez, E, de la Hoz Rodriguez, A, Di Martino, M, Di Saverio, S, Leppaniemi, A, Moore, E, Peitzman, A, Sartelli, M, Biffl, W, Fugazzola P., Cobianchi L., Dal Mas F., Cicuttin E., Dominioni T., Frassini S., Tomasoni M., Vigano J., Catena F., Ansaloni L., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Bova R., Convertini G., Agnoletti V., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Cioffi S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofia S., Licari L., Anderloni A., Maestri M., Fare C. N., Sargenti B., Improta M., Musella V., Gambini G., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Carbonell-Morote S., Rubio-Garcia J. J., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Estraviz-Mateos B., Markinez-Gordobil I., Landaluce-Olavarria A., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Martin-Perez E., de la Hoz Rodriguez A., Di Martino M., Di Saverio S., Leppaniemi A., Moore E. E., Peitzman A. B., Sartelli M., Biffl W., Fugazzola, P, Cobianchi, L, Dal Mas, F, Cicuttin, E, Dominioni, T, Frassini, S, Tomasoni, M, Vigano, J, Catena, F, Ansaloni, L, Augustin, G, Moric, T, Awad, S, Alzahrani, A, Elbahnasawy, M, Massalou, D, De Simone, B, Demetrashvili, Z, Kimpizi, A, Schizas, D, Balalis, D, Tasis, N, Papadoliopoulou, M, Georgios, P, Lasithiotakis, K, Ioannidis, O, Bains, L, Magnoli, M, Cianci, P, Conversano, N, Pasculli, A, Andreuccetti, J, Arici, E, Pignata, G, Tiberio, G, Podda, M, Murru, C, Veroux, M, Distefano, C, Centonze, D, Favi, F, Bova, R, Convertini, G, Agnoletti, V, Balla, A, Sasia, D, Giraudo, G, Gabriele, A, Tartaglia, N, Pavone, G, D'Acapito, F, Fabbri, N, Ferrara, F, Cimbanassi, S, Ferrario, L, Cioffi, S, Ceresoli, M, Fumagalli, C, Degrate, L, Degiuli, M, Sofia, S, Licari, L, Anderloni, A, Maestri, M, Fare, C, Sargenti, B, Improta, M, Musella, V, Gambini, G, Patriti, A, Coletta, D, Conti, L, Malerba, M, Andrea, M, Calabro, M, De Zolt, B, Bellio, G, Giordano, A, Luppi, D, Corbellini, C, Sampietro, G, Marafante, C, Rossi, S, Mingoli, A, Lapolla, P, Cicerchia, P, Siragusa, L, Grande, M, Arcudi, C, Antonelli, A, Vinci, D, De Martino, C, Armellino, M, Bisogno, E, Visconti, D, Santarelli, M, Montanari, E, Biloslavo, A, Germani, P, Zaghi, C, Oka, N, Fathi, M, Rios-Cruz, D, Hernandez, E, Garzali, I, Duarte, L, Negoi, I, Litvin, A, Chowdhury, S, Alshahrani, S, Carbonell-Morote, S, Rubio-Garcia, J, Moreira, C, Ponce, I, Mendoza-Moreno, F, Campana, A, Bayo, H, Serra, A, Estraviz-Mateos, B, Markinez-Gordobil, I, Landaluce-Olavarria, A, Serradilla-Martin, M, Cano-Paredero, A, Dobon-Rascon, M, Hamid, H, Baraket, O, Gonullu, E, Leventoglu, S, Turk, Y, Buyukkasap, C, Aday, U, Kara, Y, Kabuli, H, Atici, S, Colak, E, Chooklin, S, Chuklin, S, Martin-Perez, E, de la Hoz Rodriguez, A, Di Martino, M, Di Saverio, S, Leppaniemi, A, Moore, E, Peitzman, A, Sartelli, M, Biffl, W, Fugazzola P., Cobianchi L., Dal Mas F., Cicuttin E., Dominioni T., Frassini S., Tomasoni M., Vigano J., Catena F., Ansaloni L., Augustin G., Moric T., Awad S., Alzahrani A. M., Elbahnasawy M., Massalou D., De Simone B., Demetrashvili Z., Kimpizi A. -D., Schizas D., Balalis D., Tasis N., Papadoliopoulou M., Georgios P., Lasithiotakis K., Ioannidis O., Bains L., Magnoli M., Cianci P., Conversano N. I., Pasculli A., Andreuccetti J., Arici E., Pignata G., Tiberio G. A. M., Podda M., Murru C., Veroux M., Distefano C., Centonze D., Favi F., Bova R., Convertini G., Agnoletti V., Balla A., Sasia D., Giraudo G., Gabriele A., Tartaglia N., Pavone G., D'Acapito F., Fabbri N., Ferrara F., Cimbanassi S., Ferrario L., Cioffi S., Ceresoli M., Fumagalli C., Degrate L., Degiuli M., Sofia S., Licari L., Anderloni A., Maestri M., Fare C. N., Sargenti B., Improta M., Musella V., Gambini G., Patriti A., Coletta D., Conti L., Malerba M., Andrea M., Calabro M., De Zolt B., Bellio G., Giordano A., Luppi D., Corbellini C., Sampietro G. M., Marafante C., Rossi S., Mingoli A., Lapolla P., Cicerchia P. M., Siragusa L., Grande M., Arcudi C., Antonelli A., Vinci D., De Martino C., Armellino M. F., Bisogno E., Visconti D., Santarelli M., Montanari E., Biloslavo A., Germani P., Zaghi C., Oka N., Fathi M. A., Rios-Cruz D., Hernandez E. E. L., Garzali I. U., Duarte L., Negoi I., Litvin A., Chowdhury S., Alshahrani S. M., Carbonell-Morote S., Rubio-Garcia J. J., Moreira C. C. L., Ponce I. A., Mendoza-Moreno F., Campana A. M., Bayo H. L., Serra A. C., Estraviz-Mateos B., Markinez-Gordobil I., Landaluce-Olavarria A., Serradilla-Martin M., Cano-Paredero A., Dobon-Rascon M. A., Hamid H., Baraket O., Gonullu E., Leventoglu S., Turk Y., Buyukkasap C., Aday U., Kara Y., Kabuli H. A., Atici S. D., Colak E., Chooklin S., Chuklin S., Martin-Perez E., de la Hoz Rodriguez A., Di Martino M., Di Saverio S., Leppaniemi A., Moore E. E., Peitzman A. B., Sartelli M., and Biffl W.
- Abstract
Background: Existing guidelines for predicting common bile duct stones (CBDS) are not specific for acute calculous cholecystitis (ACC). This paper is a posthoc analysis of the S.P.Ri.M.A.C.C study aiming to prospectively validate on a large independent cohort of patients the Israeli Score (IS) in predicting CBDS in patients with ACC. Methods: The S.P.Ri.M.A.C.C. study is an observational multicenter prospective study endorsed by the World Society of Emergency Surgery (WSES). Between September 1st, 2021, and September 1st, 2022, 1201 participants were included. The Chi-Square test was used to compare categorical data. A Cochran-Armitage test was run to determine whether a linear trend existed between the IS and the presence of CBDS. To assess the accuracy of the prediction model, the receiver operating characteristic (ROC) curve was generated, and the area under the ROC curve (AUC) was calculated. Logistic regression was run to obtain Odds Ratio (OR). A two-tailed p < 0.05 was considered statistically significant. Results: The rate of CBDS was 1.8% in patients with an IS of 0, 4.2% in patients with an IS of 1, 24.5% in patients with 2 and 56.3% in patients with 3 (p < 0.001). The Cochran-Armitage test of trend showed a statistically significant linear trend, p < 0.001. Patients with an IS of 3 had 64.4 times (95% CI 24.8–166.9) higher odds of having associated CBDS than patients with an IS of 0. The AUC of the ROC curve of IS for the prediction of CBDS was 0.809 (95% CI 0.752–0.865, p < 0.001). By applying the highest cut-off point (3), the specificity reached 99%, while using the lowest cut-off value (0), the sensitivity reached 100%. Conclusion: The IS is a reliable tool to predict CBDS associated with ACC. The algorithm derived from the IS could optimize the management of patients with ACC.
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- 2023
19. Use of IBD Drugs in Patients with Hepatobiliary Comorbidities: Tips and Tricks
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Massironi, S, Pirola, L, Mulinacci, G, Ciaccio, A, Vigano, C, Palermo, A, Zilli, A, Invernizzi, P, Danese, S, Massironi S., Pirola L., Mulinacci G., Ciaccio A., Vigano C., Palermo A., Zilli A., Invernizzi P., Danese S., Massironi, S, Pirola, L, Mulinacci, G, Ciaccio, A, Vigano, C, Palermo, A, Zilli, A, Invernizzi, P, Danese, S, Massironi S., Pirola L., Mulinacci G., Ciaccio A., Vigano C., Palermo A., Zilli A., Invernizzi P., and Danese S.
- Abstract
Advanced therapies (biologic agents and small molecules) for inflammatory bowel diseases (IBD) have radically changed the management of these diseases during the last decade. Data about these drugs in patients with hepatic disorders derive mainly from real-life studies, as these conditions often represent an exclusion criterion from pivotal drug developmental trials. However, IBD patients sometimes have concomitant liver diseases. Nonalcoholic fatty liver disease is the most prevalent hepatic comorbidity, whereas viral hepatitis, primary sclerosing cholangitis, primary biliary cholangitis, autoimmune hepatitis, and hepatic vascular disorders are less frequent. This review aimed at describing the real-life data about the use of advanced therapies for IBD in patients with concomitant hepatobiliary disorders. Hepatitis B virus and hepatitis C virus infections do not represent an absolute contraindication for novel IBD therapeutic agents. Data from the literature suggest a safe hepatobiliary profile of biologic agents and small molecules in the case of nonalcoholic fatty liver disease, autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cholangitis, and portal vein thrombosis. Consequently, although the liver disease does not affect a different therapeutic approach in patients with concomitant IBD and liver disease, a close risk/benefit analysis for each drug should be performed in these patients, especially in cirrhotic patients and in the postliver transplant setting.
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- 2023
20. Vaccination Recommendations in Solid Organ Transplant Adult Candidates and Recipients
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Vigano, M, Beretta, M, Lepore, M, Abete, R, Benatti, S, Grassini, M, Camagni, S, Chiodini, G, Vargiu, S, Vittori, C, Iachini, M, Terzi, A, Neri, F, Pinelli, D, Casotti, V, Di Marco, F, Ruggenenti, P, Rizzi, M, Colledan, M, Fagiuoli, S, Vigano M., Beretta M., Lepore M., Abete R., Benatti S. V., Grassini M. V., Camagni S., Chiodini G., Vargiu S., Vittori C., Iachini M., Terzi A., Neri F., Pinelli D., Casotti V., Di Marco F., Ruggenenti P., Rizzi M., Colledan M., Fagiuoli S., Vigano, M, Beretta, M, Lepore, M, Abete, R, Benatti, S, Grassini, M, Camagni, S, Chiodini, G, Vargiu, S, Vittori, C, Iachini, M, Terzi, A, Neri, F, Pinelli, D, Casotti, V, Di Marco, F, Ruggenenti, P, Rizzi, M, Colledan, M, Fagiuoli, S, Vigano M., Beretta M., Lepore M., Abete R., Benatti S. V., Grassini M. V., Camagni S., Chiodini G., Vargiu S., Vittori C., Iachini M., Terzi A., Neri F., Pinelli D., Casotti V., Di Marco F., Ruggenenti P., Rizzi M., Colledan M., and Fagiuoli S.
- Abstract
Prevention of infections is crucial in solid organ transplant (SOT) candidates and recipients. These patients are exposed to an increased infectious risk due to previous organ insufficiency and to pharmacologic immunosuppression. Besides infectious-related morbidity and mortality, this vulnerable group of patients is also exposed to the risk of acute decompensation and organ rejection or failure in the pre- and post-transplant period, respectively, since antimicrobial treatments are less effective than in the immunocompetent patients. Vaccination represents a major preventive measure against specific infectious risks in this population but as responses to vaccines are reduced, especially in the early post-transplant period or after treatment for rejection, an optimal vaccination status should be obtained prior to transplantation whenever possible. This review reports the currently available data on the indications and protocols of vaccination in SOT adult candidates and recipients.
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- 2023
21. ECLAPTE: Effective Closure of LAParoTomy in Emergency-2023 World Society of Emergency Surgery guidelines for the closure of laparotomy in emergency settings
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Frassini, S, Cobianchi, L, Fugazzola, P, Biffl, W, Coccolini, F, Damaskos, D, Moore, E, Kluger, Y, Ceresoli, M, Coimbra, R, Davies, J, Kirkpatrick, A, Di Carlo, I, Hardcastle, T, Isik, A, Chiarugi, M, Gurusamy, K, Maier, R, Segovia Lohse, H, Jeekel, H, Boermeester, M, Abu-Zidan, F, Inaba, K, Weber, D, Augustin, G, Bonavina, L, Velmahos, G, Sartelli, M, Di Saverio, S, Ten Broek, R, Granieri, S, Dal Mas, F, Fare, C, Peverada, J, Zanghi, S, Vigano, J, Tomasoni, M, Dominioni, T, Cicuttin, E, Hecker, A, Tebala, G, Galante, J, Wani, I, Khokha, V, Sugrue, M, Scalea, T, Tan, E, Malangoni, M, Pararas, N, Podda, M, De Simone, B, Ivatury, R, Cui, Y, Kashuk, J, Peitzman, A, Kim, F, Pikoulis, E, Sganga, G, Chiara, O, Kelly, M, Marzi, I, Picetti, E, Agnoletti, V, De'Angelis, N, Campanelli, G, de Moya, M, Litvin, A, Martinez-Perez, A, Sall, I, Rizoli, S, Tomadze, G, Sakakushev, B, Stahel, P, Civil, I, Shelat, V, Costa, D, Chichom-Mefire, A, Latifi, R, Chirica, M, Amico, F, Pardhan, A, Seenarain, V, Boyapati, N, Hatz, B, Ackermann, T, Abeyasundara, S, Fenton, L, Plani, F, Sarvepalli, R, Rouhbakhshfar, O, Caleo, P, Ho-Ching Yau, V, Clement, K, Christou, E, Castillo, A, Gosal, P, Balasubramaniam, S, Hsu, J, Banphawatanarak, K, Pisano, M, Adriana, T, Michele, A, Cioffi, S, Spota, A, Catena, F, Ansaloni, L, Frassini S., Cobianchi L., Fugazzola P., Biffl W. L., Coccolini F., Damaskos D., Moore E. E., Kluger Y., Ceresoli M., Coimbra R., Davies J., Kirkpatrick A., Di Carlo I., Hardcastle T. C., Isik A., Chiarugi M., Gurusamy K., Maier R. V., Segovia Lohse H. A., Jeekel H., Boermeester M. A., Abu-Zidan F., Inaba K., Weber D. G., Augustin G., Bonavina L., Velmahos G., Sartelli M., Di Saverio S., Ten Broek R. P. G., Granieri S., Dal Mas F., Fare C. N., Peverada J., Zanghi S., Vigano J., Tomasoni M., Dominioni T., Cicuttin E., Hecker A., Tebala G. D., Galante J. M., Wani I., Khokha V., Sugrue M., Scalea T. M., Tan E., Malangoni M. A., Pararas N., Podda M., De Simone B., Ivatury R., Cui Y., Kashuk J., Peitzman A., Kim F., Pikoulis E., Sganga G., Chiara O., Kelly M. D., Marzi I., Picetti E., Agnoletti V., De'Angelis N., Campanelli G., de Moya M., Litvin A., Martinez-Perez A., Sall I., Rizoli S., Tomadze G., Sakakushev B., Stahel P. F., Civil I., Shelat V., Costa D., Chichom-Mefire A., Latifi R., Chirica M., Amico F., Pardhan A., Seenarain V., Boyapati N., Hatz B., Ackermann T., Abeyasundara S., Fenton L., Plani F., Sarvepalli R., Rouhbakhshfar O., Caleo P., Ho-Ching Yau V., Clement K., Christou E., Castillo A. M. G., Gosal P. K. S., Balasubramaniam S., Hsu J., Banphawatanarak K., Pisano M., Adriana T., Michele A., Cioffi S. P. B., Spota A., Catena F., Ansaloni L., Frassini, S, Cobianchi, L, Fugazzola, P, Biffl, W, Coccolini, F, Damaskos, D, Moore, E, Kluger, Y, Ceresoli, M, Coimbra, R, Davies, J, Kirkpatrick, A, Di Carlo, I, Hardcastle, T, Isik, A, Chiarugi, M, Gurusamy, K, Maier, R, Segovia Lohse, H, Jeekel, H, Boermeester, M, Abu-Zidan, F, Inaba, K, Weber, D, Augustin, G, Bonavina, L, Velmahos, G, Sartelli, M, Di Saverio, S, Ten Broek, R, Granieri, S, Dal Mas, F, Fare, C, Peverada, J, Zanghi, S, Vigano, J, Tomasoni, M, Dominioni, T, Cicuttin, E, Hecker, A, Tebala, G, Galante, J, Wani, I, Khokha, V, Sugrue, M, Scalea, T, Tan, E, Malangoni, M, Pararas, N, Podda, M, De Simone, B, Ivatury, R, Cui, Y, Kashuk, J, Peitzman, A, Kim, F, Pikoulis, E, Sganga, G, Chiara, O, Kelly, M, Marzi, I, Picetti, E, Agnoletti, V, De'Angelis, N, Campanelli, G, de Moya, M, Litvin, A, Martinez-Perez, A, Sall, I, Rizoli, S, Tomadze, G, Sakakushev, B, Stahel, P, Civil, I, Shelat, V, Costa, D, Chichom-Mefire, A, Latifi, R, Chirica, M, Amico, F, Pardhan, A, Seenarain, V, Boyapati, N, Hatz, B, Ackermann, T, Abeyasundara, S, Fenton, L, Plani, F, Sarvepalli, R, Rouhbakhshfar, O, Caleo, P, Ho-Ching Yau, V, Clement, K, Christou, E, Castillo, A, Gosal, P, Balasubramaniam, S, Hsu, J, Banphawatanarak, K, Pisano, M, Adriana, T, Michele, A, Cioffi, S, Spota, A, Catena, F, Ansaloni, L, Frassini S., Cobianchi L., Fugazzola P., Biffl W. L., Coccolini F., Damaskos D., Moore E. E., Kluger Y., Ceresoli M., Coimbra R., Davies J., Kirkpatrick A., Di Carlo I., Hardcastle T. C., Isik A., Chiarugi M., Gurusamy K., Maier R. V., Segovia Lohse H. A., Jeekel H., Boermeester M. A., Abu-Zidan F., Inaba K., Weber D. G., Augustin G., Bonavina L., Velmahos G., Sartelli M., Di Saverio S., Ten Broek R. P. G., Granieri S., Dal Mas F., Fare C. N., Peverada J., Zanghi S., Vigano J., Tomasoni M., Dominioni T., Cicuttin E., Hecker A., Tebala G. D., Galante J. M., Wani I., Khokha V., Sugrue M., Scalea T. M., Tan E., Malangoni M. A., Pararas N., Podda M., De Simone B., Ivatury R., Cui Y., Kashuk J., Peitzman A., Kim F., Pikoulis E., Sganga G., Chiara O., Kelly M. D., Marzi I., Picetti E., Agnoletti V., De'Angelis N., Campanelli G., de Moya M., Litvin A., Martinez-Perez A., Sall I., Rizoli S., Tomadze G., Sakakushev B., Stahel P. F., Civil I., Shelat V., Costa D., Chichom-Mefire A., Latifi R., Chirica M., Amico F., Pardhan A., Seenarain V., Boyapati N., Hatz B., Ackermann T., Abeyasundara S., Fenton L., Plani F., Sarvepalli R., Rouhbakhshfar O., Caleo P., Ho-Ching Yau V., Clement K., Christou E., Castillo A. M. G., Gosal P. K. S., Balasubramaniam S., Hsu J., Banphawatanarak K., Pisano M., Adriana T., Michele A., Cioffi S. P. B., Spota A., Catena F., and Ansaloni L.
- Abstract
Laparotomy incisions provide easy and rapid access to the peritoneal cavity in case of emergency surgery. Incisional hernia (IH) is a late manifestation of the failure of abdominal wall closure and represents frequent complication of any abdominal incision: IHs can cause pain and discomfort to the patients but also clinical serious sequelae like bowel obstruction, incarceration, strangulation, and necessity of reoperation. Previous guidelines and indications in the literature consider elective settings and evidence about laparotomy closure in emergency settings is lacking. This paper aims to present the World Society of Emergency Surgery (WSES) project called ECLAPTE (Effective Closure of LAParoTomy in Emergency): the final manuscript includes guidelines on the closure of emergency laparotomy.
- Published
- 2023
22. The Effect of Holographic Heart Models and Mixed Reality for Anatomy Learning in Congenital Heart Disease: An Exploratory Study
- Author
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D'Aiello, A, Cabitza, F, Natali, C, Vigano, S, Ferrero, P, Bognoni, L, Pasqualin, G, Giamberti, A, Chessa, M, d'Aiello A. F., Cabitza F., Natali C., Vigano S., Ferrero P., Bognoni L., Pasqualin G., Giamberti A., Chessa M., D'Aiello, A, Cabitza, F, Natali, C, Vigano, S, Ferrero, P, Bognoni, L, Pasqualin, G, Giamberti, A, Chessa, M, d'Aiello A. F., Cabitza F., Natali C., Vigano S., Ferrero P., Bognoni L., Pasqualin G., Giamberti A., and Chessa M.
- Abstract
In this paper, we present an exploratory study on the potential impact of holographic heart models and mixed reality technology on medical training, and in particular in teaching complex Congenital Heart Diseases (CHD) to medical students. Fifty-nine medical students were randomly allocated into three groups. Each participant in each group received a 30-minute lecture on a CHD condition interpretation and transcatheter treatment with different instructional tools. The participants of the first group attended a lecture in which traditional slides were projected onto a flat screen (group “regular slideware”, RS). The second group was shown slides incorporating videos of holographic anatomical models (group “holographic videos”, HV). Finally, those in the third group wore immersive, head-mounted devices (HMD) to interact directly with holographic anatomical models (group “mixed reality”, MR). At the end of the lecture, the members of each group were asked to fill in a multiple-choice questionnaire aimed at evaluating their topic proficiency, as a proxy to evaluate the effectiveness of the training session (in terms of acquired notions); participants from group MR were also asked to fill in a questionnaire regarding the recommendability and usability of the MS Hololens HMDs, as a proxy of satisfaction regarding its use experience (UX). The findings show promising results for usability and user acceptance.
- Published
- 2023
23. Economic Impact of European Liver and Intestine Transplantation Association (ELITA) Recommendations for Hepatitis B Prophylaxis After Liver Transplantation
- Author
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Cortesi, P, Vigano, R, Conti, S, Lenci, I, Volpes, R, Martini, S, Angelico, M, Fung, J, Buti, M, Coilly, A, Durand, F, Fondevila, C, Lebray, P, Nevens, F, Polak, W, Rizzetto, M, Zoulim, F, Perricone, G, Berenguer, M, Mantovani, L, Duvoux, C, Belli, L, Cortesi P. A., Vigano R., Conti S., Lenci I., Volpes R., Martini S., Angelico M., Fung J., Buti M., Coilly A., Durand F., Fondevila C., Lebray P., Nevens F., Polak W. G., Rizzetto M., Zoulim F., Perricone G., Berenguer M., Mantovani L. G., Duvoux C., Belli L. S., Cortesi, P, Vigano, R, Conti, S, Lenci, I, Volpes, R, Martini, S, Angelico, M, Fung, J, Buti, M, Coilly, A, Durand, F, Fondevila, C, Lebray, P, Nevens, F, Polak, W, Rizzetto, M, Zoulim, F, Perricone, G, Berenguer, M, Mantovani, L, Duvoux, C, Belli, L, Cortesi P. A., Vigano R., Conti S., Lenci I., Volpes R., Martini S., Angelico M., Fung J., Buti M., Coilly A., Durand F., Fondevila C., Lebray P., Nevens F., Polak W. G., Rizzetto M., Zoulim F., Perricone G., Berenguer M., Mantovani L. G., Duvoux C., and Belli L. S.
- Abstract
The European Liver and Intestine Transplant Association, ELITA, promoted a Consensus Conference involving 20 experts across the world which generated updated guidelines on HBV prophylaxis in liver transplant candidates and recipients. This study explores the economic impact associated with the implementation of the new ELITA guidelines. To this aim, a condition-specific cohort simulation model has been developed to compare new and historical prophylaxis, including only pharmaceutical cost and using the European perspective. The target population simulated in the model included both prevalent and incident cases, and consisted of 6,133 patients after the first year, that increased to 7,442 and 8,743 patents after 5 and 10 years from its implementation. The ELITA protocols allowed a cost saving of around € 235.65 million after 5 years and € 540.73 million after 10 years; which was mainly due to early HIBG withdrawal either after the first 4 weeks or after the first year post Liver Transplantation (LT) depending on the virological risk at transplantation. Results were confirmed by sensitivity analyses. The money saved by the implementation of the ELITA guidelines would allow healthcare decision makers and budget holders to understand where costs could be reduced and resources re-allocated to different needs.
- Published
- 2023
24. Surgeons’ perspectives on artificial intelligence to support clinical decision-making in trauma and emergency contexts: results from an international survey
- Author
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Cobianchi, L, Piccolo, D, Dal Mas, F, Agnoletti, V, Ansaloni, L, Balch, J, Biffl, W, Butturini, G, Catena, F, Coccolini, F, Denicolai, S, De Simone, B, Frigerio, I, Fugazzola, P, Marseglia, G, Martellucci, J, Modenese, M, Previtali, P, Ruta, F, Venturi, A, Kaafarani, H, Loftus, T, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Angelos, P, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balague, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Bidoli, C, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Dall'Orto, R, Campos-Serra, A, Campostrini, S, Capoglu, R, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Ruiz, E, Conti, L, Coppola, A, De Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, De Beaux, A, Fernandez, S, De Luca, A, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Di Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire, M, Fare, C, Farre, R, Favi, F, Ferrario, L, Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Pizzocaro, E, Frountzas, M, Gachabayov, M, Galeiras, R, Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kluger, Y, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Leppaniemi, A, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, V, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Massaro, M, Matias-Garcia, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pegoraro, V, Pellino, G, Pelloni, M, Peloso, A, Del Pozo, E, Pereira, R, Pereira, B, Perez, S, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ucar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sartelli, M, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, R, Velmahos, G, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Woltz, S, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zanghi, S, Zantedeschi, M, Zapsalis, K, Zattoni, F, Zese, M, Cobianchi L., Piccolo D., Dal Mas F., Agnoletti V., Ansaloni L., Balch J., Biffl W., Butturini G., Catena F., Coccolini F., Denicolai S., De Simone B., Frigerio I., Fugazzola P., Marseglia G., Marseglia G. R., Martellucci J., Modenese M., Previtali P., Ruta F., Venturi A., Kaafarani H. M., Loftus T. J., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Angelos P., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., Balague C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Barranquero A. G., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Bidoli C., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Dall'Orto R. C., Campos-Serra A., Campostrini S., Capoglu R., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Ruiz E. C., Conti L., Coppola A., De Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'ambrosio G., Das K., Davies R. J., De Beaux A. C., Fernandez S. P. L., De Luca A., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Di Carlo I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire M., Fare C. N., Farre R., Favi F., Ferrario L., Vajana A. F. T., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Pizzocaro E., Frountzas M., Gachabayov M., Galeiras R., Vazquez A. A. G., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., Hodonou A. M., Huaman E. C., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kluger Y., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Leppaniemi A., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., Machain V. G. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., Manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Massaro M., Matias-Garcia B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pegoraro V., Pellino G., Pelloni M., Peloso A., Del Pozo E. P., Pereira R. G., Pereira B. M., Perez A. L., Perez S., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Picetti E., Pikoulis E. P., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ucar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sartelli M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante G. T., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Velmahos G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Woltz S., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zanghi S., Zantedeschi M., Zapsalis K., Zattoni F., Zese M., Cobianchi, L, Piccolo, D, Dal Mas, F, Agnoletti, V, Ansaloni, L, Balch, J, Biffl, W, Butturini, G, Catena, F, Coccolini, F, Denicolai, S, De Simone, B, Frigerio, I, Fugazzola, P, Marseglia, G, Martellucci, J, Modenese, M, Previtali, P, Ruta, F, Venturi, A, Kaafarani, H, Loftus, T, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Angelos, P, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balague, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Bidoli, C, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Dall'Orto, R, Campos-Serra, A, Campostrini, S, Capoglu, R, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colak, E, Ruiz, E, Conti, L, Coppola, A, De Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, De Beaux, A, Fernandez, S, De Luca, A, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Di Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire, M, Fare, C, Farre, R, Favi, F, Ferrario, L, Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Pizzocaro, E, Frountzas, M, Gachabayov, M, Galeiras, R, Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kluger, Y, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Leppaniemi, A, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, Machain, V, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Massaro, M, Matias-Garcia, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pegoraro, V, Pellino, G, Pelloni, M, Peloso, A, Del Pozo, E, Pereira, R, Pereira, B, Perez, S, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Picetti, E, Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ucar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sartelli, M, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, R, Velmahos, G, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Woltz, S, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zanghi, S, Zantedeschi, M, Zapsalis, K, Zattoni, F, Zese, M, Cobianchi L., Piccolo D., Dal Mas F., Agnoletti V., Ansaloni L., Balch J., Biffl W., Butturini G., Catena F., Coccolini F., Denicolai S., De Simone B., Frigerio I., Fugazzola P., Marseglia G., Marseglia G. R., Martellucci J., Modenese M., Previtali P., Ruta F., Venturi A., Kaafarani H. M., Loftus T. J., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Angelos P., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., Balague C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Barranquero A. G., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Bidoli C., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Dall'Orto R. C., Campos-Serra A., Campostrini S., Capoglu R., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colak E., Ruiz E. C., Conti L., Coppola A., De Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'ambrosio G., Das K., Davies R. J., De Beaux A. C., Fernandez S. P. L., De Luca A., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Di Carlo I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire M., Fare C. N., Farre R., Favi F., Ferrario L., Vajana A. F. T., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Pizzocaro E., Frountzas M., Gachabayov M., Galeiras R., Vazquez A. A. G., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., Hodonou A. M., Huaman E. C., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kluger Y., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Leppaniemi A., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., Machain V. G. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., Manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Massaro M., Matias-Garcia B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pegoraro V., Pellino G., Pelloni M., Peloso A., Del Pozo E. P., Pereira R. G., Pereira B. M., Perez A. L., Perez S., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Picetti E., Pikoulis E. P., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ucar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sartelli M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., Soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante G. T., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Velmahos G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Woltz S., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zanghi S., Zantedeschi M., Zapsalis K., Zattoni F., and Zese M.
- Abstract
Background: Artificial intelligence (AI) is gaining traction in medicine and surgery. AI-based applications can offer tools to examine high-volume data to inform predictive analytics that supports complex decision-making processes. Time-sensitive trauma and emergency contexts are often challenging. The study aims to investigate trauma and emergency surgeons’ knowledge and perception of using AI-based tools in clinical decision-making processes. Methods: An online survey grounded on literature regarding AI-enabled surgical decision-making aids was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was advertised to 917 WSES members through the society’s website and Twitter profile. Results: 650 surgeons from 71 countries in five continents participated in the survey. Results depict the presence of technology enthusiasts and skeptics and surgeons’ preference toward more classical decision-making aids like clinical guidelines, traditional training, and the support of their multidisciplinary colleagues. A lack of knowledge about several AI-related aspects emerges and is associated with mistrust. Discussion: The trauma and emergency surgical community is divided into those who firmly believe in the potential of AI and those who do not understand or trust AI-enabled surgical decision-making aids. Academic societies and surgical training programs should promote a foundational, working knowledge of clinical AI.
- Published
- 2023
25. Hepatotoxicity of Small Molecule Protein Kinase Inhibitors for Cancer
- Author
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Vigano, M, La Milia, M, Grassini, M, Pugliese, N, De Giorgio, M, Fagiuoli, S, Vigano M., La Milia M., Grassini M. V., Pugliese N., De Giorgio M., Fagiuoli S., Vigano, M, La Milia, M, Grassini, M, Pugliese, N, De Giorgio, M, Fagiuoli, S, Vigano M., La Milia M., Grassini M. V., Pugliese N., De Giorgio M., and Fagiuoli S.
- Abstract
Small molecule protein kinase inhibitors (PKIs) have become an effective strategy for cancer patients. However, hepatotoxicity is a major safety concern of these drugs, since the majority are reported to increase transaminases, and few of them (Idelalisib, Lapatinib, Pazopanib, Pexidartinib, Ponatinib, Regorafenib, Sunitinib) have a boxed label warning. The exact rate of PKI-induced hepatoxicity is not well defined due to the fact that the majority of data arise from pre-registration or registration trials on fairly selected patients, and the post-marketing data are often based only on the most severe described cases, whereas most real practice studies do not include drug-related hepatotoxicity as an end point. Although these side effects are usually reversible by dose adjustment or therapy suspension, or by switching to an alternative PKI, and fatality is uncommon, all patients undergoing PKIs should be carefully pre-evaluated and monitored. The management of this complication requires an individually tailored reappraisal of the risk/benefit ratio, especially in patients who are responding to therapy. This review reports the currently available data on the risk and management of hepatotoxicity of all the approved PKIs.
- Published
- 2023
26. Time for a paradigm shift in shared decision-making in trauma and emergency surgery? Results from an international survey
- Author
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Cobianchi, L, Dal Mas, F, Agnoletti, V, Ansaloni, L, Biffl, W, Butturini, G, Campostrini, S, Catena, F, Denicolai, S, Fugazzola, P, Martellucci, J, Massaro, M, Previtali, P, Ruta, F, Venturi, A, Woltz, S, Kaafarani, H, Loftus, T, Aapoaylu, R, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Bidoli, C, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balaguacopyright, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Gonzalez Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Campo Dall'Orto, R, Campos-Serra, A, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colais-Ruiz, E, Colak, E, Conti, L, Coppola, A, de Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, de Beaux, A, De Lebrusant Fernandez, S, De Luca, A, De Simone, B, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, Dios-Barbeito, S, Diyani, J, Dogjani, A, Domanin, M, D'Oria, M, Munoz-Cruzado, V, East, B, Ekelund, M, Ekwen, G, Elbaih, A, Elhadi, M, Enninghorst, N, Ernisova, M, Escalera-Antezana, J, Esposito, S, Esposito, G, Estaire-Gamez, M, Fara, C, Farre, R, Favi, F, Ferrario, L, Ferrario di Tor Vajana, A, Filisetti, C, Fleres, F, Fonseca, V, Forero-Torres, A, Forfori, F, Fortuna, L, Fradelos, E, Fraga, G, Fransvea, P, Frassini, S, Frazzetta, G, Frigerio, I, Frountzas, M, Gachabayov, M, Galeiras, R, Garcaa, B, Garcia Vazquez, A, Gargarella, S, Garzali, I, Ghannam, W, Ghazi, F, Gillman, L, Gioco, R, Giordano, A, Giordano, L, Giove, C, Giraudo, G, Giuffrida, M, Capponi, M, Gois, E, Gomes, C, Gomes, F, Gonsaga, R, Gonullu, E, Goosen, J, Goranovic, T, Gracia-Roman, R, Graziano, G, Griffiths, E, Guagni, T, Hadzhiev, D, Haidar, M, Hamid, H, Hardcastle, T, Hayati, F, Healey, A, Hecker, A, Hecker, M, Garcia, E, Hodonou, A, Huaman, E, Huerta, M, Ibrahim, A, Ibrahim, B, Ietto, G, Inama, M, Ioannidis, O, Isik, A, Ismail, N, Ismail, A, Jailani, R, Jang, J, Kalfountzos, C, Kalipershad, S, Kaouras, E, Kaplan, L, Kara, Y, Karamagioli, E, Karamarkovia, A, Katsaros, I, Kavalakat, A, Kechagias, A, Kenig, J, Kessel, B, Khan, J, Khokha, V, Kim, J, Kirkpatrick, A, Klappenbach, R, Kobe, Y, Lymperis, E, Kok, K, Kong, V, Korkolis, D, Koukoulis, G, Kovacevic, B, Kruger, V, Kryvoruchko, I, Kurihara, H, Kuriyama, A, Landaluce-Olavarria, A, Lapolla, P, Licari, L, Lisi, G, Litvin, A, Lizarazu, A, Bayo, H, Lohsiriwat, V, Moreira, C, Lostoridis, E, Luna, A, Luppi, D, V, G, Maegele, M, Maggiore, D, Magnone, S, Maier, R, Major, P, Manangi, M, Manetti, A, Mantoglu, B, Marafante, C, Mariani, F, Marinis, A, Mariot, E, Marseglia, G, Martanez-Parez, A, Martines, G, Perez, A, Martino, C, Mascagni, P, Massalou, D, Mataas-Garcaa, B, Mazzarella, G, Mazzarolo, G, Melo, R, Mendoza-Moreno, F, Meric, S, Meyer, J, Miceli, L, Michalopoulos, N, Milana, F, Mingoli, A, Mishra, T, Mohamed, M, Mohamedahmed, A, Mohammed, M, Mohan, R, Moore, E, Morales-Garcia, D, Muhrbeck, M, Mulita, F, Mustafa, S, Muttillo, E, Naimzada, M, Navsaria, P, Negoi, I, Nespoli, L, Nguyen, C, Nidaw, M, Nigri, G, Nikolopoulos, I, O'Connor, D, Ogundipe, H, Oliveri, C, Olmi, S, Ong, E, Orecchia, L, Osipov, A, Othman, M, Pace, M, Pacilli, M, Pagani, L, Palomba, G, Pantalone, D, Panyko, A, Paolillo, C, Papa, M, Papaconstantinou, D, Papadoliopoulou, M, Papadopoulos, A, Papis, D, Pararas, N, Parreira, J, Parry, N, Pata, F, Patel, T, Paterson-Brown, S, Pavone, G, Pecchini, F, Pellino, G, Pelloni, M, Peloso, A, del Pozo, E, Pereira, R, Pereira, B, Perra, T, Perrone, G, Pesce, A, Petagna, L, Petracca, G, Phupong, V, Picardi, B, Picciariello, A, Piccoli, M, Piccolo, D, Picetti, E, Pikoulis Pikoulis, E, Pintar, T, Pirozzolo, G, Piscioneri, F, Podda, M, Porcu, A, Privitera, F, Punzo, C, Quaresima, S, Quiodettis, M, Qvist, N, Rahim, R, de Almeida, F, Ramely, R, Rasa, H, Reichert, M, Reinisch-Liese, A, Renne, A, Riccetti, C, Rodriguez-Luna, M, Roizblatt, D, Romanzi, A, Romeo, L, Roscio, F, Rosnelifaizur, R, Rossi, S, Rubiano, A, Ruiz-Ascar, E, Sakakushev, B, Salamea, J, Sall, I, Samarakoon, L, Sammartano, F, Arteaga, A, Sanchez-Cordero, S, Santoanastaso, D, Sasia, D, Sato, N, Savchuk, A, Sawyer, R, Scaioli, G, Schizas, D, Sebastiani, S, Seeliger, B, Lohse, H, Seretis, C, Sermonesi, G, Serradilla-Martin, M, Shelat, V, Shlyapnikov, S, Sidiropoulos, T, Simoes, R, Siragusa, L, Siribumrungwong, B, Slavchev, M, Solaini, L, Soldini, G, Sopuev, A, Soreide, K, Sovatzidis, A, Stahel, P, Strickland, M, Sultan, M, Sydorchuk, R, Sydorchuk, L, Syed, S, Syed, A, Tallon-Aguilar, L, Tamburini, A, Tamini, N, Tan, E, Tan, J, Tarasconi, A, Tartaglia, N, Tartaglia, G, Tartaglia, D, Taylor, J, Tebala, G, Teuben, M, Theodorou, A, Tolonen, M, Tomasicchio, G, Toro, A, Torre, B, Triantafyllou, T, Trigiante Trigiante, G, Tripepi, M, Trostchansky, J, Tsekouras, K, Turrado-Rodriguez, V, Tutino, R, Uccelli, M, Uchikov, P, Ugarte-Sierra, B, Ukkonen, M, Vailas, M, Vassiliu, P, Vazquez, A, Vazquez, R, Verde, J, Veroux, M, Vigano, J, Vilallonga, R, Visconti, D, Vittori, A, Waledziak, M, Wannatoop, T, Widmer, L, Wilson, M, Wong, T, Xenaki, S, Yu, B, Yule, S, Zachariah, S, Zacharis, G, Zaghi, C, Zakaria, A, Zambrano, D, Zampitis, N, Zampogna, B, Zangha, S, Zapsalis, K, Zattoni, F, Zese, M, Farre, S, Pegoraro, V, Zantedeschi, M, Reitano, E, Pizzocaro, E, Cobianchi L., Dal Mas F., Agnoletti V., Ansaloni L., Biffl W., Butturini G., Campostrini S., Catena F., Denicolai S., Fugazzola P., Martellucci J., Massaro M., Previtali P., Ruta F., Venturi A., Woltz S., Kaafarani H. M., Loftus T. J., Aapoaylu R., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Bidoli C., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Arvieux C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., BalaguaCopyright C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Gonzalez Barranquero A., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Campo Dall'Orto R., Campos-Serra A., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colais-Ruiz E., Colak E., Conti L., Coppola A., de Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'Ambrosio G., Das K., Davies R. J., de Beaux A. C., De Lebrusant Fernandez S. P., De Luca A., De Simone B., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Carlo I. -D. I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire-Gamez M., Fara C. N., Farre R., Favi F., Ferrario L., Ferrario di Tor Vajana A., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Frigerio I., Frountzas M., Gachabayov M., Galeiras R., Garcaa B. M., Garcia Vazquez A., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., hodonou A. M., huaman E., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., V G. M. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Marseglia G. R., Martanez-Parez A., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Mataas-Garcaa B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'Connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., del Pozo E. P., Pereira R. G., Pereira B. M., perez A. L., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Piccolo D., Picetti E., Pikoulis Pikoulis E., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ascar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Syed A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante Trigiante G., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zangha S., Zapsalis K., Zattoni F., Zese M., Farre S. P., Pegoraro V., Zantedeschi M., Reitano E., Pizzocaro E., Cobianchi, L, Dal Mas, F, Agnoletti, V, Ansaloni, L, Biffl, W, Butturini, G, Campostrini, S, Catena, F, Denicolai, S, Fugazzola, P, Martellucci, J, Massaro, M, Previtali, P, Ruta, F, Venturi, A, Woltz, S, Kaafarani, H, Loftus, T, Aapoaylu, R, Abbott, K, Abdelmalik, A, Abebe, N, Abu-Zidan, F, Adam, Y, Adamou, H, Adamovich, D, Agresta, F, Agrusa, A, Akin, E, Alessiani, M, Alexandrino, H, Bidoli, C, Ali, S, Mihai, V, Almeida, P, Al-Shehari, M, Altomare, M, Amico, F, Ammendola, M, Andreuccetti, J, Anestiadou, E, Annicchiarico, A, Antonelli, A, Aparicio-Sanchez, D, Ardito, A, Argenio, G, Arvieux, C, Askevold, I, Atanasov, B, Augustin, G, Awad, S, Bacchiocchi, G, Bagnoli, C, Bahouth, H, Baili, E, Bains, L, Baiocchi, G, Bala, M, Balaguacopyright, C, Balalis, D, Baldini, E, Baraket, O, Baral, S, Barone, M, Gonzalez Barranquero, A, Barreras, J, Bass, G, Bayhan, Z, Bellanova, G, Ben-Ishay, O, Bert, F, Bianchi, V, Biancuzzi, H, Radulescu, R, Bignell, M, Biloslavo, A, Bini, R, Bissacco, D, Boati, P, Boddaert, G, Bogdanic, B, Bombardini, C, Bonavina, L, Bonomo, L, Bottari, A, Bouliaris, K, Brachini, G, Brillantino, A, Brisinda, G, Bulanauca, M, Buonomo, L, Burcharth, J, Buscemi, S, Calabretto, F, Calini, G, Calu, V, Campanile, F, Campo Dall'Orto, R, Campos-Serra, A, Carvas, J, Cascella, M, Pattacini, G, Celentano, V, Centonze, D, Ceresoli, M, Chatzipetris, D, Chessa, A, Chiarello, M, Chirica, M, Chooklin, S, Chouliaras, C, Chowdhury, S, Cianci, P, Cillara, N, Cimbanassi, S, Cioffi, S, Colais-Ruiz, E, Colak, E, Conti, L, Coppola, A, de Sa, T, Costa, S, Cozza, V, Curro', G, Dabekaussen, K, D'Acapito, F, Damaskos, D, D'Ambrosio, G, Das, K, Davies, R, de Beaux, A, De Lebrusant Fernandez, S, De Luca, A, De Simone, B, De Stefano, F, Degrate, L, Demetrashvili, Z, Demetriades, A, Detanac, D, Dezi, A, Di Buono, G, Carlo, I, Di Lascio, P, Di Martino, M, Di Saverio, S, Diaconescu, B, Diaz, J, Dibra, R, Dimitrov, E, Dinuzzi, V, 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M., Loftus T. J., Aapoaylu R., Abbott K. L., Abdelmalik A., Abebe N. S., Abu-Zidan F., Adam Y. A. Y., Adamou H., Adamovich D. M., Agresta F., Agrusa A., Akin E., Alessiani M., Alexandrino H., Bidoli C., Ali S. M., Mihai V. A., Almeida P. M., Al-Shehari M. M., Altomare M., Amico F., Ammendola M., Andreuccetti J., Anestiadou E., Annicchiarico A., Antonelli A., Aparicio-Sanchez D., Ardito A., Argenio G., Arvieux C. C., Arvieux C., Askevold I. H., Atanasov B. T., Augustin G., Awad S. S., Bacchiocchi G., Bagnoli C., Bahouth H., Baili E., Bains L., Baiocchi G. L., Bala M., BalaguaCopyright C., Balalis D., Baldini E., Baraket O., Baral S., Barone M., Gonzalez Barranquero A., Barreras J. A., Bass G. A., Bayhan Z., Bellanova G., Ben-Ishay O., Bert F., Bianchi V., Biancuzzi H., Radulescu R. B., Bignell M. B., Biloslavo A., Bini R., Bissacco D., Boati P., Boddaert G., Bogdanic B., Bombardini C., Bonavina L., Bonomo L., Bottari A., Bouliaris K., Brachini G., Brillantino A., Brisinda G., Bulanauca M. M., Buonomo L. A., Burcharth J., Buscemi S., Calabretto F., Calini G., Calu V., Campanile F. C., Campo Dall'Orto R., Campos-Serra A., Carvas J. M., Cascella M., Pattacini G. C., Celentano V., Centonze D. C., Ceresoli M., Chatzipetris D., Chessa A., Chiarello M. M., Chirica M., Chooklin S., Chouliaras C., Chowdhury S., Cianci P., Cillara N., Cimbanassi S., Cioffi S. P. B., Colais-Ruiz E., Colak E., Conti L., Coppola A., de Sa T. C., Costa S. D., Cozza V., Curro' G., Dabekaussen K. F. A. -S. A., D'acapito F., Damaskos D., D'Ambrosio G., Das K., Davies R. J., de Beaux A. C., De Lebrusant Fernandez S. P., De Luca A., De Simone B., De Stefano F., Degrate L., Demetrashvili Z., Demetriades A. K., Detanac D. S., Dezi A., Di Buono G., Carlo I. -D. I., Di Lascio P., Di Martino M., Di Saverio S., Diaconescu B., Diaz J. J., Dibra R., Dimitrov E. N., Dinuzzi V. P., Dios-Barbeito S., Diyani J. F. A., Dogjani A., Domanin M., D'Oria M., Munoz-Cruzado V. D., East B., Ekelund M., Ekwen G. T., Elbaih A. H., Elhadi M., Enninghorst N., Ernisova M., Escalera-Antezana J. P., Esposito S., Esposito G., Estaire-Gamez M., Fara C. N., Farre R., Favi F., Ferrario L., Ferrario di Tor Vajana A., Filisetti C., Fleres F., Fonseca V. C., Forero-Torres A., Forfori F., Fortuna L., Fradelos E., Fraga G. P., Fransvea P., Frassini S., Frazzetta G., Frigerio I., Frountzas M., Gachabayov M., Galeiras R., Garcaa B. M., Garcia Vazquez A., Gargarella S., Garzali I. U., Ghannam W. M., Ghazi F. N., Gillman L. M., Gioco R., Giordano A., Giordano L., Giove C., Giraudo G., Giuffrida M., Capponi M. G., Gois E., Gomes C. A., Gomes F. C., Gonsaga R. A. T., Gonullu E., Goosen J., Goranovic T., Gracia-Roman R., Graziano G. M. P., Griffiths E. A., Guagni T., Hadzhiev D. B., Haidar M. G., Hamid H. K. S., Hardcastle T. C., Hayati F., Healey A. J., Hecker A., Hecker M., Garcia E. F. H., hodonou A. M., huaman E., Huerta M., Ibrahim A. F., Ibrahim B. M. S., Ietto G., Inama M., Ioannidis O., Isik A., Ismail N., Ismail A. M. H., Jailani R. F., Jang J. Y., Kalfountzos C., Kalipershad S. N. R., Kaouras E., Kaplan L. J., Kara Y., Karamagioli E., Karamarkovia A., Katsaros I., Kavalakat A. J., Kechagias A., Kenig J., Kessel B. J., Khan J. S., Khokha V., Kim J. I., Kirkpatrick A. W., Klappenbach R., Kobe Y., Lymperis E. K., Kok K. Y. Y., Kong V., Korkolis D. P., Koukoulis G., Kovacevic B., Kruger V. F., Kryvoruchko I. A., Kurihara H., Kuriyama A., Landaluce-Olavarria A., Lapolla P., Licari L., Lisi G., Litvin A., Lizarazu A., Bayo H. L., Lohsiriwat V., Moreira C. C. L., Lostoridis E., Luna A. T., Luppi D., V G. M. M., Maegele M., Maggiore D., Magnone S., Maier R. V., Major P., Manangi M., manetti A., Mantoglu B., Marafante C., Mariani F., Marinis A., Mariot E. A. S., Marseglia G. R., Martanez-Parez A., Martines G., Perez A. M., Martino C., Mascagni P., Massalou D., Mataas-Garcaa B., Mazzarella G., Mazzarolo G., Melo R. B., Mendoza-Moreno F., Meric S., Meyer J., Miceli L., Michalopoulos N. V., Milana F., Mingoli A., Mishra T. S., Mohamed M., Mohamed M. I. E. A., Mohamedahmed A. Y., Mohammed M. J. S., Mohan R., Moore E. E., Morales-Garcia D., Muhrbeck M., Mulita F., Mustafa S. M. S., Muttillo E. M., Naimzada M. D., Navsaria P. H., Negoi I., Nespoli L., Nguyen C., Nidaw M. K., Nigri G., Nikolopoulos I., O'Connor D. B., Ogundipe H. D., Oliveri C., Olmi S., Ong E. C. W., Orecchia L., Osipov A. V., Othman M. F., Pace M., Pacilli M., Pagani L., Palomba G., Pantalone D., Panyko A., Paolillo C., Papa M. V., Papaconstantinou D., Papadoliopoulou M., Papadopoulos A., Papis D., Pararas N., Parreira J. G., Parry N. G., Pata F., Patel T., Paterson-Brown S., Pavone G., Pecchini F., Pellino G., Pelloni M., Peloso A., del Pozo E. P., Pereira R. G., Pereira B. M., perez A. L., Perra T., Perrone G., Pesce A., Petagna L., Petracca G., Phupong V., Picardi B., Picciariello A., Piccoli M., Piccolo D., Picetti E., Pikoulis Pikoulis E., Pintar T., Pirozzolo G., Piscioneri F., Podda M., Porcu A., Privitera F., Punzo C., Quaresima S., Quiodettis M. A., Qvist N., Rahim R., de Almeida F. R., Ramely R. B., Rasa H. K., Reichert M., Reinisch-Liese A., Renne A., Riccetti C., Rodriguez-Luna M. R., Roizblatt D., Romanzi A., Romeo L., Roscio F. P. M., Rosnelifaizur R. B., Rossi S., Rubiano A. M., Ruiz-Ascar E., Sakakushev B. E., Salamea J. C., Sall I., Samarakoon L. B., Sammartano F., Arteaga A. S., Sanchez-Cordero S., Santoanastaso D. P. M., Sasia D., Sato N., Savchuk A., Sawyer R. G., Scaioli G., Schizas D., Sebastiani S., Seeliger B., Lohse H. A. S., Seretis C., Sermonesi G., Serradilla-Martin M., Shelat V. G., Shlyapnikov S., Sidiropoulos T., Simoes R. L., Siragusa L., Siribumrungwong B., Slavchev M., Solaini L., soldini G., Sopuev A., Soreide K., Sovatzidis A., Stahel P. F., Strickland M., Sultan M. A. H., Sydorchuk R., Sydorchuk L., Syed S. M. A. M., Syed A. M., Tallon-Aguilar L., Tamburini A. M., Tamini N., Tan E. C. T. H., Tan J. H., Tarasconi A., Tartaglia N., Tartaglia G., Tartaglia D., Taylor J. V., Tebala G. D., Teuben M., Theodorou A., Tolonen M., Tomasicchio G., Toro A., Torre B., Triantafyllou T., Trigiante Trigiante G., Tripepi M., Trostchansky J., Tsekouras K., Turrado-Rodriguez V., Tutino R., Uccelli M., Uchikov P. A., Ugarte-Sierra B., Ukkonen M. T., Vailas M., Vassiliu P. G., Vazquez A. G., Vazquez R. G., Verde J. E., Verde J. M., Veroux M., Vigano J., Vilallonga R., Visconti D., Vittori A., Waledziak M., Wannatoop T., Widmer L. W., Wilson M. S. J., Wong T. H., Xenaki S., Yu B., Yule S., Zachariah S. K., Zacharis G., Zaghi C., Zakaria A. D., Zambrano D. A., Zampitis N., Zampogna B., Zangha S., Zapsalis K., Zattoni F., Zese M., Farre S. P., Pegoraro V., Zantedeschi M., Reitano E., and Pizzocaro E.
- Abstract
Background: Shared decision-making (SDM) between clinicians and patients is one of the pillars of the modern patient-centric philosophy of care. This study aims to explore SDM in the discipline of trauma and emergency surgery, investigating its interpretation as well as the barriers and facilitators for its implementation among surgeons. Methods: Grounding on the literature on the topics of the understanding, barriers, and facilitators of SDM in trauma and emergency surgery, a survey was created by a multidisciplinary committee and endorsed by the World Society of Emergency Surgery (WSES). The survey was sent to all 917 WSES members, advertised through the society’s website, and shared on the society’s Twitter profile. Results: A total of 650 trauma and emergency surgeons from 71 countries in five continents participated in the initiative. Less than half of the surgeons understood SDM, and 30% still saw the value in exclusively engaging multidisciplinary provider teams without involving the patient. Several barriers to effectively partnering with the patient in the decision-making process were identified, such as the lack of time and the need to concentrate on making medical teams work smoothly. Discussion: Our investigation underlines how only a minority of trauma and emergency surgeons understand SDM, and perhaps, the value of SDM is not fully accepted in trauma and emergency situations. The inclusion of SDM practices in clinical guidelines may represent the most feasible and advocated solutions.
- Published
- 2023
27. Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study
- Author
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Sanchez-Guillen, L, Caravaca, I, Triguero-Canovas, D, Aparicio, A, Melendez, B, Palacios, A, Landaluce-Olavarria, A, De Francisco, M, Estraviz-Mateos, B, Alconchel, F, Nicolas-Lopez, T, Ramirez, P, Munoz-Cruzado, V, Ciuro, F, del Pozo, E, Pizarro, S, Cabrera, V, Bayo, J, Hamid, H, Roesel, R, Cristaudi, A, Abbas, K, Ali, I, Tlili, A, Bayhan, H, Turkoglu, M, Uzunoglu, M, Azamat, I, Omarov, N, Uymaz, D, Altintoprak, F, Akin, E, First, N, Das, K, Ozer, N, Seker, A, Kara, Y, Bozkurt, M, Kocatas, A, Atici, S, Akalin, M, Calik, B, Colak, E, Altinel, Y, Meric, S, Aktimur, Y, Hudson, V, Duval, J, Khan, M, Saad, A, Kaur, M, Bradley, A, Fox, K, Tomasi, I, Beasley, D, Prasanti, A, Kotecha, P, Ebied, H, Paul, M, Sheth, H, Gerogiannis, I, Gaber, M, Sheikh, Z, Seth, S, Kunitsyna, M, Leo, C, Bellato, V, Zafar, N, Elserafy, A, Bond-smith, G, Tebala, G, Mathur, P, Abid, I, Chidumije, N, Sandhar, P, Ullah, S, Lezama, T, Anwaar, M, Magee, C, Ahmed, S, Davies, B, Apollos, J, Mccormack, K, Choudhary, H, Doulias, T, Morrison, T, Palepa, A, Cal, F, Sanchez, L, Dominguez, F, Al-Raimi, I, Alshargabi, H, Meead, A, Chooklin, S, Chuklin, S, Bilyak, A, Podda M., Pellino G., Di Saverio S., Coccolini F., Pacella D., Cioffi S. P. B., Virdis F., Balla A., Ielpo B., Pata F., Poillucci G., Ortenzi M., Damaskos D., De Simone B., Sartelli M., Leppaniemi A., Jayant K., Catena F., Giuliani A., Di Martino M., Pisanu A., Gerardi C., Gourgiotis S., Riboni C., Giordano A., Ferrario L., Agnoletti V., Kruger Y., Mole D., Agresta F., Prieto Calvo M., Wilson M., Soggiu F., Hamdan A., Gomes C. A., Fraga G., Ioannidis A., Demetrashvili Z., Sahani S., Bains L., Khamees A., Ababneh H., Aljaiuossi O., Pimentel S., Mohamad I. S., Yusoff A. R., Zarnescu N. O., Calu V., Litvin A., Lesko D., Elmehrath A., Elshami M., de Santibanes M., Gundara J., Alawadhi K., Lui R., Julianov A., Ralon S., Garzali I. -U., Machain G. M., Villalabeitia I., Quispe-Cruz D. A., Orantia A. C. C., Waledziak M., de Sa T. C., Ali S. M., Kovacevic B., Noel C., Abdalah H. M., Kchaou A., Isik A., Ansaloni L., Biffl W., Guerrieri M., Sartori A., Abradelo M., Nigri G., Di Lorenzo N., Mingoli A., Chiarugi M., Di Menno Stavron J., Mazza O., Valenzuela J. I., Pachajoa D. A. P., Alvarez F. A., Liano J. E., Tefay J., Alshaikh A., Hasan L., Couto Gomes F., Calderan T. R. A., Hirano E. S., Dardanov D., Saroglu A., Atanasov B., Belev N., Kovachev N., Chan S. M., Lok H. -T., Salcedo D., Robayo D., Trivino M. A., Manak J., de Araujo J., Sethi A., Awad A., Elbadawy M., Farid A., Hanafy A., Nafea A., Sherief G., Salah Alzhraa A., Abdelsalam W., Emile S., Elfallal A., Elfeki H., Elghadban H., Shoma A., Shetiwy M., Elbahnasawy M., Mohamed S., Hamed E. F., Khalil U. A., Chouillard E., Gumbs A., Police A., Mabilia A., Khutsishvili K., Tvaladze A., Ioannidis O., Anestiadou E., Loutzidou L., Konstantinidis K., Konstantinidou S., Manatakis D., Acheimastos V., Tasis N., Michalopoulos N., Kokoropoulos P., Papadoliopoulou M., Sotiropoulou M., Kapiris S., Metaxas P., Tsouknidas I., Kefili D., Petrakis G., Synekidou E., Dakis K., Alexandridou E., Papadopoulos A., Chouliaras C., Mouzakis O., Mulita F., Maroulis I., Vailas M., Triantafyllou T., Theodorou D., Lostoridis E., Nagorni E. -A., Tourountzi P., Baili E., Charalabopoulos A., Liakakos T., Schizas D., Kozadinos A., Syllaios A., Machairas N., Kykalos S., Stamopoulos P., Delis S., Farazi-Chongouki C., Kalaitzakis E., Giannarakis M., Lasithiotakis K., Petra G., Gupta A., Medappil N., Muthukrishnan V., Kamar J., Lal P., Agarwal R., Magnoli M., Aonzo P., Serventi A., Di Lascio P., Pinto M., Bergamini C., Bottari A., Fortuna L., Martellucci J., Cicako A., Miglietta C., Morino M., Delogu D., Picchetto A., Assenza M., D'Ambrosio G., Argenio G., Armellino M. F., Ioia G., Occhionorelli S., Andreotti D., Domenico L., Luppi D., Casadei M., Di Donato L., Manoochehri F., Marchese T. R. L., Sergi W., Manca R., Murgia R., Piras E., Conti L., Gianazza S., Rizzi A., Segalini E., Monti M., Iiritano E., Mariani N. M., De Nicola E., Scifo G., Pignata G., Andreuccetti J., Fleres F., Clarizia G., Spolini A., Biloslavo A., Germani P., Mastronardi M., Bogoni S., Palmisano S., De Manzini N., Marino M. V., Martines G., Trigiante G., Lagouvardou E., Anania G., Bombardini C., Oppici D., Pilia T., Murzi V., Gessa E., Bracale U., Di Nuzzo M. M., Peltrini R., Salvetti F., Vigano J., Sganga G., Bianchi V., Fransvea P., Fontana T., Sarro G., Dinuzzi V. P., Scaravilli L., Papa M. V., Jovine E., Ciabatti G., Mastrangelo L., Rottoli M., Ricci C., Russo I. S., Aiolfi A., Bona D., Lombardo F., Cianci P., Sederino M., Bini R., Chiara O., Cioffi S., Cantafio S., Coretti G., Licitra E., Savino G., Grimaldi S., Porfidia R., Moggia E., Garino M., Marafante C., Pesce A., Fabbri N., Feo C. V., Marra E., Troian M., Drigo D., Nagliati C., Muratore A., Danna R., Murgese A., Crespi M., Guerci C., Frontali A., Ferrari L., Favi F., Picariello E., Rampini A., D'Acapito F., Ercolani G., Solaini L., Palmieri F., Cali M., Ferrara F., Muttillo I. A., Muttillo E. M., Picardi B., Galleano R., Badran A., Ghazouani O., Cervellera M., Campanella G., Papa G., Di Bella A., Perrone G., Petracca G. L., Prioriello C., Giuffrida M., Cozzani F., Rossini M., Inama M., Butturini G., Moretto G., Morelli L., Candio G., Guadagni S., Cicuttin E., Cremonini C., Tartaglia D., Genovese V., Cillara N., Cannavera A., Deserra A., Picciariello A., Papagni V., Vincenti L., Bagaglini G., Sica G., Lapolla P., Brachini G., Bono D., Nicotera A., Zago M., Sammartano F., Benuzzi L., Stella M., Rossi S., Cerioli A., Puccioni C., Olmi S., Rubicondo C., Uccelli M., Guida A., Lepiane P., Sasia D., Giraudo G., Salomone S., Belloni E., Cossa A., Lancellotti F., Caronna R., Chirletti P., Saullo P., Troiano R., Mucilli F., Barone M., Ippoliti M., Grande M., Sensi B., Siragusa L., Santini A., Di Carlo I., Veroux M., Gioco R., Veroux G., Curro G., Ammendola M., Komaei I., Navarra G., Tonini V., Sartarelli L., Ceresoli M., Perrone S., Roccamatisi L., Millo P., Brachet Contul R., Ponte E., Zuin M., Portale G., Tonello A. S., Fratini G., Bianchini M., Perotti B., Doria E., Lunghi E. G., Visconti D., Al-Shami K., Awadi S., Buwaitel M. M. K., Naffa' M. F. N., Samhouri A., Sawalha H., Ani M. F. C., Fathil I. N. A., Huei J., Beristain-Hernandez J. -L., Garcia-Meza A., Sepulveda-Rdriguez R., Hernandez E. E. L., Pinzon C. L. A., Condoy J. N., Garcia F. C. B., Sadik M., Kadir B., Devi J., Seerani N., Sohail-Asghar M., Afzal A., Akbar A., Lohse H. S., Cabrera Z. S. L., Seto G. S. Y., Chiuyari J. R., Ordemar J., Rodriguez M., Orantia-Carlos A. C. C., Quitoy M. A., Kwiatkowski A., Mawlichanow M., Rocha M., Soares C., Stoian A. R., Draghici A. D., Grigorean V. T., Radulescu R. B., Costea R. V., Zarnescu E. C., Kurtenkov M., Gendrikson G., Alla-Angelina V., Arina T., Kaldarov A., Gachabayov M., Abdullaev A., Milentijevic M., Karamarkovic M., Panyko A., Radonak J., Soltes M., Moran L. A., Garcia H. C., Vega P. S., Estevez S., Ausania F., Farguell J., Gonzalez-Abos C., Sanchez-Cabus S., Martin B., Molina V., Oms L., Ilzarbe L., Feijoo E. P., Perra E. S., Rojas-Bonet N., Penalba-Palmi R., Perez-Bru S., Tur-Martinez J., Alvarez-Torrado A., Domingo-Gonzalez M., Tejedor-Tejada J., del Alamo Y. G., Mendoza-Moreno F., Garcia-Moreno-Nisa F., Matias-Garcia B., Duran M., Calleja-Lozano R., de Villar J. M. P., Sanchez-Guillen L., Caravaca I., Triguero-Canovas D., Aparicio A. C. M., Melendez B. D., Palacios A. M., Landaluce-Olavarria A., De Francisco M., Estraviz-Mateos B., Alconchel F., Nicolas-Lopez T., Ramirez P., Munoz-Cruzado V. D., Ciuro F. P., del Pozo E. P., Pizarro S. O., Cabrera V. H., Bayo J. M., Hamid H. K. S., Roesel R., Cristaudi A., Abbas K., Ali I., Tlili A., Bayhan H., Turkoglu M. A., Uzunoglu M. Y., Azamat I. F., Omarov N., Uymaz D. S., Altintoprak F., Akin E., First N., Das K., Ozer N., Seker A., Kara Y., Bozkurt M. A., Kocatas A., Atici S. D., Akalin M., Calik B., Colak E., Altinel Y., Meric S., Aktimur Y. E., Hudson V., Duval J. -L., Khan M., Saad A., Kaur M., Bradley A., Fox K., Tomasi I., Beasley D., Prasanti A. K., Kotecha P., Ebied H., Paul M., Sheth H., Gerogiannis I., Gaber M., Sheikh Z., Seth S., Kunitsyna M., Leo C. A., Bellato V., Zafar N., Elserafy A., Bond-smith G., Tebala G., Mathur P., Abid I., Chidumije N., Sandhar P., Ullah S. O. Z., Lezama T., Anwaar M. H., Magee C., Ahmed S., Davies B., Apollos J., McCormack K., Choudhary H., Doulias T., Morrison T., Palepa A., Cal F. B., Sanchez L., Dominguez F., Al-Raimi I., Alshargabi H., Meead A., Chooklin S., Chuklin S., Bilyak A., Podda, M, Pellino, G, Di Saverio, S, Coccolini, F, Pacella, D, Cioffi, S, Virdis, F, Balla, A, Ielpo, B, Pata, F, Poillucci, G, Ortenzi, M, Damaskos, D, De Simone, B, Sartelli, M, Leppaniemi, A, Jayant, K, Catena, F, Giuliani, A, Di Martino, M, Pisanu, A, Gerardi, C, Gourgiotis, S, Riboni, C, Giordano, A, Ferrario, L, Agnoletti, V, Kruger, Y, Mole, D, Agresta, F, Prieto Calvo, M, Wilson, M, Soggiu, F, Hamdan, A, Gomes, C, Fraga, G, Ioannidis, A, Demetrashvili, Z, Sahani, S, Bains, L, Khamees, A, Ababneh, H, Aljaiuossi, O, Pimentel, S, Mohamad, I, Yusoff, A, Zarnescu, N, Calu, V, Litvin, A, Lesko, D, Elmehrath, A, Elshami, M, de Santibanes, M, Gundara, J, Alawadhi, K, Lui, R, Julianov, A, Ralon, S, Garzali, I, Machain, G, Villalabeitia, I, Quispe-Cruz, D, Orantia, A, Waledziak, M, de Sa, T, Ali, S, Kovacevic, B, Noel, C, Abdalah, H, Kchaou, A, Isik, A, Ansaloni, L, Biffl, W, Guerrieri, M, Sartori, A, Abradelo, M, Nigri, G, Di Lorenzo, N, Mingoli, A, Chiarugi, M, Di Menno Stavron, J, Mazza, O, Valenzuela, J, Pachajoa, D, Alvarez, F, Liano, J, Tefay, J, Alshaikh, A, Hasan, L, Couto Gomes, F, Calderan, T, Hirano, E, Dardanov, D, Saroglu, A, Atanasov, B, Belev, N, Kovachev, N, Chan, S, Lok, H, Salcedo, D, Robayo, D, Trivino, M, Manak, J, de Araujo, J, Sethi, A, Awad, A, Elbadawy, M, Farid, A, Hanafy, A, Nafea, A, Sherief, G, Salah Alzhraa, A, Abdelsalam, W, Emile, S, Elfallal, A, Elfeki, H, Elghadban, H, Shoma, A, Shetiwy, M, Elbahnasawy, M, Mohamed, S, Hamed, E, Khalil, U, Chouillard, E, Gumbs, A, Police, A, Mabilia, A, Khutsishvili, K, Tvaladze, A, Ioannidis, O, Anestiadou, E, Loutzidou, L, Konstantinidis, K, Konstantinidou, S, Manatakis, D, Acheimastos, V, Tasis, N, Michalopoulos, N, Kokoropoulos, P, Papadoliopoulou, M, Sotiropoulou, M, Kapiris, S, Metaxas, P, Tsouknidas, I, Kefili, D, Petrakis, G, Synekidou, E, Dakis, K, Alexandridou, E, Papadopoulos, A, Chouliaras, C, Mouzakis, O, Mulita, F, Maroulis, I, Vailas, M, Triantafyllou, T, Theodorou, D, Lostoridis, E, Nagorni, E, Tourountzi, P, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Kozadinos, A, Syllaios, A, Machairas, N, Kykalos, S, Stamopoulos, P, Delis, S, Farazi-Chongouki, C, Kalaitzakis, E, Giannarakis, M, Lasithiotakis, K, Petra, G, Gupta, A, Medappil, N, Muthukrishnan, V, Kamar, J, Lal, P, Agarwal, R, Magnoli, M, Aonzo, P, Serventi, A, Di Lascio, P, Pinto, M, Bergamini, C, Bottari, A, Fortuna, L, Martellucci, J, Cicako, A, Miglietta, C, Morino, M, Delogu, D, Picchetto, A, Assenza, M, D'Ambrosio, G, Argenio, G, Armellino, M, Ioia, G, Occhionorelli, S, Andreotti, D, Domenico, L, Luppi, D, Casadei, M, Di Donato, L, Manoochehri, F, Marchese, T, Sergi, W, Manca, R, Murgia, R, Piras, E, Conti, L, Gianazza, S, Rizzi, A, Segalini, E, Monti, M, Iiritano, E, Mariani, N, De Nicola, E, Scifo, G, Pignata, G, Andreuccetti, J, Fleres, F, Clarizia, G, Spolini, A, Biloslavo, A, Germani, P, Mastronardi, M, Bogoni, S, Palmisano, S, De Manzini, N, Marino, M, Martines, G, Trigiante, G, Lagouvardou, E, Anania, G, Bombardini, C, Oppici, D, Pilia, T, Murzi, V, Gessa, E, Bracale, U, Di Nuzzo, M, Peltrini, R, Salvetti, F, Vigano, J, Sganga, G, Bianchi, V, Fransvea, P, Fontana, T, Sarro, G, Dinuzzi, V, Scaravilli, L, Papa, M, Jovine, E, Ciabatti, G, Mastrangelo, L, Rottoli, M, Ricci, C, Russo, I, Aiolfi, A, Bona, D, Lombardo, F, Cianci, P, Sederino, M, Bini, R, Chiara, O, Cantafio, S, Coretti, G, Licitra, E, Savino, G, Grimaldi, S, Porfidia, R, Moggia, E, Garino, M, Marafante, C, Pesce, A, Fabbri, N, Feo, C, Marra, E, Troian, M, Drigo, D, Nagliati, C, Muratore, A, Danna, R, Murgese, A, Crespi, M, Guerci, C, Frontali, A, Ferrari, L, Favi, F, Picariello, E, Rampini, A, D'Acapito, F, Ercolani, G, Solaini, L, Palmieri, F, Cali, M, Ferrara, F, Muttillo, I, Muttillo, E, Picardi, B, Galleano, R, Badran, A, Ghazouani, O, Cervellera, M, Campanella, G, Papa, G, Di Bella, A, Perrone, G, Petracca, G, Prioriello, C, Giuffrida, M, Cozzani, F, Rossini, M, Inama, M, Butturini, G, Moretto, G, Morelli, L, Candio, G, Guadagni, S, Cicuttin, E, Cremonini, C, Tartaglia, D, Genovese, V, Cillara, N, Cannavera, A, Deserra, A, Picciariello, A, Papagni, V, Vincenti, L, Bagaglini, G, Sica, G, Lapolla, P, Brachini, G, Bono, D, Nicotera, A, Zago, M, Sammartano, F, Benuzzi, L, Stella, M, Rossi, S, Cerioli, A, Puccioni, C, Olmi, S, Rubicondo, C, Uccelli, M, Guida, A, Lepiane, P, Sasia, D, Giraudo, G, Salomone, S, Belloni, E, Cossa, A, Lancellotti, F, Caronna, R, Chirletti, P, Saullo, P, Troiano, R, Mucilli, F, Barone, M, Ippoliti, M, Grande, M, Sensi, B, Siragusa, L, Santini, A, Di Carlo, I, Veroux, M, Gioco, R, Veroux, G, Curro, G, Ammendola, M, Komaei, I, Navarra, G, Tonini, V, Sartarelli, L, Ceresoli, M, Perrone, S, Roccamatisi, L, Millo, P, Brachet Contul, R, Ponte, E, Zuin, M, Portale, G, Tonello, A, Fratini, G, Bianchini, M, Perotti, B, Doria, E, Lunghi, E, Visconti, D, Al-Shami, K, Awadi, S, Buwaitel, M, Naffa', M, Samhouri, A, Sawalha, H, Ani, M, Fathil, I, Huei, J, Beristain-Hernandez, J, Garcia-Meza, A, Sepulveda-Rdriguez, R, Hernandez, E, Pinzon, C, Condoy, J, Garcia, F, Sadik, M, Kadir, B, Devi, J, Seerani, N, Zainab, Sohail-Asghar, M, Afzal, A, Akbar, A, Lohse, H, Cabrera, Z, Seto, G, Chiuyari, J, Ordemar, J, Rodriguez, M, Orantia-Carlos, A, Quitoy, M, Kwiatkowski, A, Mawlichanow, M, Rocha, M, Soares, C, Stoian, A, Draghici, A, Grigorean, V, Radulescu, R, Costea, R, Zarnescu, E, Kurtenkov, M, Gendrikson, G, Alla-Angelina, V, Arina, T, Kaldarov, A, Gachabayov, M, Abdullaev, A, Milentijevic, M, Karamarkovic, M, Panyko, A, Radonak, J, Soltes, M, Moran, L, Garcia, H, Vega, P, Estevez, S, Ausania, F, Farguell, J, Gonzalez-Abos, C, Sanchez-Cabus, S, Martin, B, Molina, V, Oms, L, Ilzarbe, L, Feijoo, E, Perra, E, Rojas-Bonet, N, Penalba-Palmi, R, Perez-Bru, S, Tur-Martinez, J, Alvarez-Torrado, A, Domingo-Gonzalez, M, Tejedor-Tejada, J, del Alamo, Y, Mendoza-Moreno, F, Garcia-Moreno-Nisa, F, Matias-Garcia, B, Duran, M, Calleja-Lozano, R, de Villar, J, Sanchez-Guillen, L, Caravaca, I, Triguero-Canovas, D, Aparicio, A, Melendez, B, Palacios, A, Landaluce-Olavarria, A, De Francisco, M, Estraviz-Mateos, B, Alconchel, F, Nicolas-Lopez, T, Ramirez, P, Munoz-Cruzado, V, Ciuro, F, del Pozo, E, Pizarro, S, Cabrera, V, Bayo, J, Hamid, H, Roesel, R, Cristaudi, A, Abbas, K, Ali, I, Tlili, A, Bayhan, H, Turkoglu, M, Uzunoglu, M, Azamat, I, Omarov, N, Uymaz, D, Altintoprak, F, Akin, E, First, N, Das, K, Ozer, N, Seker, A, Kara, Y, Bozkurt, M, Kocatas, A, Atici, S, Akalin, M, Calik, B, Colak, E, Altinel, Y, Meric, S, Aktimur, Y, Hudson, V, Duval, J, Khan, M, Saad, A, Kaur, M, Bradley, A, Fox, K, Tomasi, I, Beasley, D, Prasanti, A, Kotecha, P, Ebied, H, Paul, M, Sheth, H, Gerogiannis, I, Gaber, M, Sheikh, Z, Seth, S, Kunitsyna, M, Leo, C, Bellato, V, Zafar, N, Elserafy, A, Bond-smith, G, Tebala, G, Mathur, P, Abid, I, Chidumije, N, Sandhar, P, Ullah, S, Lezama, T, Anwaar, M, Magee, C, Ahmed, S, Davies, B, Apollos, J, Mccormack, K, Choudhary, H, Doulias, T, Morrison, T, Palepa, A, Cal, F, Sanchez, L, Dominguez, F, Al-Raimi, I, Alshargabi, H, Meead, A, Chooklin, S, Chuklin, S, Bilyak, A, Podda M., Pellino G., Di Saverio S., Coccolini F., Pacella D., Cioffi S. P. B., Virdis F., Balla A., Ielpo B., Pata F., Poillucci G., Ortenzi M., Damaskos D., De Simone B., Sartelli M., Leppaniemi A., Jayant K., Catena F., Giuliani A., Di Martino M., Pisanu A., Gerardi C., Gourgiotis S., Riboni C., Giordano A., Ferrario L., Agnoletti V., Kruger Y., Mole D., Agresta F., Prieto Calvo M., Wilson M., Soggiu F., Hamdan A., Gomes C. A., Fraga G., Ioannidis A., Demetrashvili Z., Sahani S., Bains L., Khamees A., Ababneh H., Aljaiuossi O., Pimentel S., Mohamad I. S., Yusoff A. R., Zarnescu N. O., Calu V., Litvin A., Lesko D., Elmehrath A., Elshami M., de Santibanes M., Gundara J., Alawadhi K., Lui R., Julianov A., Ralon S., Garzali I. -U., Machain G. M., Villalabeitia I., Quispe-Cruz D. A., Orantia A. C. C., Waledziak M., de Sa T. C., Ali S. M., Kovacevic B., Noel C., Abdalah H. M., Kchaou A., Isik A., Ansaloni L., Biffl W., Guerrieri M., Sartori A., Abradelo M., Nigri G., Di Lorenzo N., Mingoli A., Chiarugi M., Di Menno Stavron J., Mazza O., Valenzuela J. I., Pachajoa D. A. P., Alvarez F. A., Liano J. E., Tefay J., Alshaikh A., Hasan L., Couto Gomes F., Calderan T. R. A., Hirano E. S., Dardanov D., Saroglu A., Atanasov B., Belev N., Kovachev N., Chan S. M., Lok H. -T., Salcedo D., Robayo D., Trivino M. A., Manak J., de Araujo J., Sethi A., Awad A., Elbadawy M., Farid A., Hanafy A., Nafea A., Sherief G., Salah Alzhraa A., Abdelsalam W., Emile S., Elfallal A., Elfeki H., Elghadban H., Shoma A., Shetiwy M., Elbahnasawy M., Mohamed S., Hamed E. F., Khalil U. A., Chouillard E., Gumbs A., Police A., Mabilia A., Khutsishvili K., Tvaladze A., Ioannidis O., Anestiadou E., Loutzidou L., Konstantinidis K., Konstantinidou S., Manatakis D., Acheimastos V., Tasis N., Michalopoulos N., Kokoropoulos P., Papadoliopoulou M., Sotiropoulou M., Kapiris S., Metaxas P., Tsouknidas I., Kefili D., Petrakis G., Synekidou E., Dakis K., Alexandridou E., Papadopoulos A., Chouliaras C., Mouzakis O., Mulita F., Maroulis I., Vailas M., Triantafyllou T., Theodorou D., Lostoridis E., Nagorni E. -A., Tourountzi P., Baili E., Charalabopoulos A., Liakakos T., Schizas D., Kozadinos A., Syllaios A., Machairas N., Kykalos S., Stamopoulos P., Delis S., Farazi-Chongouki C., Kalaitzakis E., Giannarakis M., Lasithiotakis K., Petra G., Gupta A., Medappil N., Muthukrishnan V., Kamar J., Lal P., Agarwal R., Magnoli M., Aonzo P., Serventi A., Di Lascio P., Pinto M., Bergamini C., Bottari A., Fortuna L., Martellucci J., Cicako A., Miglietta C., Morino M., Delogu D., Picchetto A., Assenza M., D'Ambrosio G., Argenio G., Armellino M. F., Ioia G., Occhionorelli S., Andreotti D., Domenico L., Luppi D., Casadei M., Di Donato L., Manoochehri F., Marchese T. R. L., Sergi W., Manca R., Murgia R., Piras E., Conti L., Gianazza S., Rizzi A., Segalini E., Monti M., Iiritano E., Mariani N. M., De Nicola E., Scifo G., Pignata G., Andreuccetti J., Fleres F., Clarizia G., Spolini A., Biloslavo A., Germani P., Mastronardi M., Bogoni S., Palmisano S., De Manzini N., Marino M. V., Martines G., Trigiante G., Lagouvardou E., Anania G., Bombardini C., Oppici D., Pilia T., Murzi V., Gessa E., Bracale U., Di Nuzzo M. M., Peltrini R., Salvetti F., Vigano J., Sganga G., Bianchi V., Fransvea P., Fontana T., Sarro G., Dinuzzi V. P., Scaravilli L., Papa M. V., Jovine E., Ciabatti G., Mastrangelo L., Rottoli M., Ricci C., Russo I. S., Aiolfi A., Bona D., Lombardo F., Cianci P., Sederino M., Bini R., Chiara O., Cioffi S., Cantafio S., Coretti G., Licitra E., Savino G., Grimaldi S., Porfidia R., Moggia E., Garino M., Marafante C., Pesce A., Fabbri N., Feo C. V., Marra E., Troian M., Drigo D., Nagliati C., Muratore A., Danna R., Murgese A., Crespi M., Guerci C., Frontali A., Ferrari L., Favi F., Picariello E., Rampini A., D'Acapito F., Ercolani G., Solaini L., Palmieri F., Cali M., Ferrara F., Muttillo I. A., Muttillo E. M., Picardi B., Galleano R., Badran A., Ghazouani O., Cervellera M., Campanella G., Papa G., Di Bella A., Perrone G., Petracca G. L., Prioriello C., Giuffrida M., Cozzani F., Rossini M., Inama M., Butturini G., Moretto G., Morelli L., Candio G., Guadagni S., Cicuttin E., Cremonini C., Tartaglia D., Genovese V., Cillara N., Cannavera A., Deserra A., Picciariello A., Papagni V., Vincenti L., Bagaglini G., Sica G., Lapolla P., Brachini G., Bono D., Nicotera A., Zago M., Sammartano F., Benuzzi L., Stella M., Rossi S., Cerioli A., Puccioni C., Olmi S., Rubicondo C., Uccelli M., Guida A., Lepiane P., Sasia D., Giraudo G., Salomone S., Belloni E., Cossa A., Lancellotti F., Caronna R., Chirletti P., Saullo P., Troiano R., Mucilli F., Barone M., Ippoliti M., Grande M., Sensi B., Siragusa L., Santini A., Di Carlo I., Veroux M., Gioco R., Veroux G., Curro G., Ammendola M., Komaei I., Navarra G., Tonini V., Sartarelli L., Ceresoli M., Perrone S., Roccamatisi L., Millo P., Brachet Contul R., Ponte E., Zuin M., Portale G., Tonello A. S., Fratini G., Bianchini M., Perotti B., Doria E., Lunghi E. G., Visconti D., Al-Shami K., Awadi S., Buwaitel M. M. K., Naffa' M. F. N., Samhouri A., Sawalha H., Ani M. F. C., Fathil I. N. A., Huei J., Beristain-Hernandez J. -L., Garcia-Meza A., Sepulveda-Rdriguez R., Hernandez E. E. L., Pinzon C. L. A., Condoy J. N., Garcia F. C. B., Sadik M., Kadir B., Devi J., Seerani N., Sohail-Asghar M., Afzal A., Akbar A., Lohse H. S., Cabrera Z. S. L., Seto G. S. Y., Chiuyari J. R., Ordemar J., Rodriguez M., Orantia-Carlos A. C. C., Quitoy M. A., Kwiatkowski A., Mawlichanow M., Rocha M., Soares C., Stoian A. R., Draghici A. D., Grigorean V. T., Radulescu R. B., Costea R. V., Zarnescu E. C., Kurtenkov M., Gendrikson G., Alla-Angelina V., Arina T., Kaldarov A., Gachabayov M., Abdullaev A., Milentijevic M., Karamarkovic M., Panyko A., Radonak J., Soltes M., Moran L. A., Garcia H. C., Vega P. S., Estevez S., Ausania F., Farguell J., Gonzalez-Abos C., Sanchez-Cabus S., Martin B., Molina V., Oms L., Ilzarbe L., Feijoo E. P., Perra E. S., Rojas-Bonet N., Penalba-Palmi R., Perez-Bru S., Tur-Martinez J., Alvarez-Torrado A., Domingo-Gonzalez M., Tejedor-Tejada J., del Alamo Y. G., Mendoza-Moreno F., Garcia-Moreno-Nisa F., Matias-Garcia B., Duran M., Calleja-Lozano R., de Villar J. M. P., Sanchez-Guillen L., Caravaca I., Triguero-Canovas D., Aparicio A. C. M., Melendez B. D., Palacios A. M., Landaluce-Olavarria A., De Francisco M., Estraviz-Mateos B., Alconchel F., Nicolas-Lopez T., Ramirez P., Munoz-Cruzado V. D., Ciuro F. P., del Pozo E. P., Pizarro S. O., Cabrera V. H., Bayo J. M., Hamid H. K. S., Roesel R., Cristaudi A., Abbas K., Ali I., Tlili A., Bayhan H., Turkoglu M. A., Uzunoglu M. Y., Azamat I. F., Omarov N., Uymaz D. S., Altintoprak F., Akin E., First N., Das K., Ozer N., Seker A., Kara Y., Bozkurt M. A., Kocatas A., Atici S. D., Akalin M., Calik B., Colak E., Altinel Y., Meric S., Aktimur Y. E., Hudson V., Duval J. -L., Khan M., Saad A., Kaur M., Bradley A., Fox K., Tomasi I., Beasley D., Prasanti A. K., Kotecha P., Ebied H., Paul M., Sheth H., Gerogiannis I., Gaber M., Sheikh Z., Seth S., Kunitsyna M., Leo C. A., Bellato V., Zafar N., Elserafy A., Bond-smith G., Tebala G., Mathur P., Abid I., Chidumije N., Sandhar P., Ullah S. O. Z., Lezama T., Anwaar M. H., Magee C., Ahmed S., Davies B., Apollos J., McCormack K., Choudhary H., Doulias T., Morrison T., Palepa A., Cal F. B., Sanchez L., Dominguez F., Al-Raimi I., Alshargabi H., Meead A., Chooklin S., Chuklin S., and Bilyak A.
- Abstract
The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135–15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359–5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138–5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184–5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598–9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090–6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286–5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912–7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138–0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143–0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible.
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- 2023
28. Similar survival but higher and delayed hepatocellular carcinoma recurrence in HIV-positive compared to negative cirrhotics undergoing liver transplantation
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Rossotti, R, Merli, M, Mazzarelli, C, De Carlis, R, Travi, G, Vecchi, M, Vigano, R, Lauterio, A, Raimondi, A, Belli, L, De Carlis, L, Puoti, M, Rossotti R., Merli M., Mazzarelli C., De Carlis R. M., Travi G., Vecchi M., Vigano R., Lauterio A., Raimondi A., Belli L. S., De Carlis L. G., Puoti M., Rossotti, R, Merli, M, Mazzarelli, C, De Carlis, R, Travi, G, Vecchi, M, Vigano, R, Lauterio, A, Raimondi, A, Belli, L, De Carlis, L, Puoti, M, Rossotti R., Merli M., Mazzarelli C., De Carlis R. M., Travi G., Vecchi M., Vigano R., Lauterio A., Raimondi A., Belli L. S., De Carlis L. G., and Puoti M.
- Abstract
Background: Liver transplantation (LT) represents the best therapeutic option for hepatocellular carcinoma (HCC) and end-stage liver disease (ESLD). Although HIV infection does not seem to lower survival rates, HCV and HCC recurrence appear more harmful. Aims: To compare the overall survival after LT; evaluate the impact of anti-HCV direct-acting agents (DAA); assess the rate of HCC recurrence in HIV-positive and negative patients. Methods: Subjects with HCV/HBV infection who underwent LT for HCC or ESLD from 2012 to 2019 were retrospectively evaluated. Results: Study population included 299 individuals, 31 (10.4%) were HIV-positive. Overall mortality was similar (16.1% versus 19.0%, p = 0.695). HCC recurrence was observed in 6 HIV-positive (19.4%) and in 17 negative subjects (6.3%, p = 0.022). Time to relapse was 831 days in HIV-positive and 315 days in negative patients (p = 0.046). Cox model found a significant role for HIV in univariate analysis but, after adjusting for variables, extra-hepatic tumor was the only factor associated to recurrence (aHR 56.379, p < 0.001). Conclusions: Post-LT survival improved after DAA availability and HIV has no impact on mortality. A higher and delayed rate of HCC recurrence was observed in co-infected individuals: surveillance protocols should be strengthened along time in this population.
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- 2023
29. Reduced humoral response to two doses of COVID-19 vaccine in patients with inflammatory bowel disease: Data from ESCAPE-IBD, an IG-IBD study
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Macaluso, F, Principi, M, Facciotti, F, Contaldo, A, Todeschini, A, Saibeni, S, Bezzio, C, Castiglione, F, Nardone, O, Spagnuolo, R, Fantini, M, Riguccio, G, Caprioli, F, Vigano, C, Felice, C, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Mannino, M, Rizzo, G, Orlando, A, Amato, A, Ascolani, M, Calabrese, G, Casa, A, Comberlato, M, Conforti, F, De Bona, M, Demarzo, M, Doldo, P, Dragoni, G, Furfaro, F, Mulinacci, G, Olmo, O, O'Sed, N, Paba, S, Radice, S, Renna, S, Ribaldone, D, Rizzuto, G, Macaluso F. S., Principi M., Facciotti F., Contaldo A., Todeschini A., Saibeni S., Bezzio C., Castiglione F., Nardone O. M., Spagnuolo R., Fantini M. C., Riguccio G., Caprioli F., Vigano C., Felice C., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Mannino M., Rizzo G., Orlando A., Amato A., Ascolani M., Calabrese G., Casa A., Comberlato M., Conforti F. S., De Bona M., Demarzo M. G., Doldo P., Dragoni G., Furfaro F., Mulinacci G., Olmo O., O'Sed N. P., Paba S., Radice S., Renna S., Ribaldone D. G., Rizzuto G., Macaluso, F, Principi, M, Facciotti, F, Contaldo, A, Todeschini, A, Saibeni, S, Bezzio, C, Castiglione, F, Nardone, O, Spagnuolo, R, Fantini, M, Riguccio, G, Caprioli, F, Vigano, C, Felice, C, Fiorino, G, Correale, C, Bodini, G, Milla, M, Scardino, G, Vernero, M, Desideri, F, Mannino, M, Rizzo, G, Orlando, A, Amato, A, Ascolani, M, Calabrese, G, Casa, A, Comberlato, M, Conforti, F, De Bona, M, Demarzo, M, Doldo, P, Dragoni, G, Furfaro, F, Mulinacci, G, Olmo, O, O'Sed, N, Paba, S, Radice, S, Renna, S, Ribaldone, D, Rizzuto, G, Macaluso F. S., Principi M., Facciotti F., Contaldo A., Todeschini A., Saibeni S., Bezzio C., Castiglione F., Nardone O. M., Spagnuolo R., Fantini M. C., Riguccio G., Caprioli F., Vigano C., Felice C., Fiorino G., Correale C., Bodini G., Milla M., Scardino G., Vernero M., Desideri F., Mannino M., Rizzo G., Orlando A., Amato A., Ascolani M., Calabrese G., Casa A., Comberlato M., Conforti F. S., De Bona M., Demarzo M. G., Doldo P., Dragoni G., Furfaro F., Mulinacci G., Olmo O., O'Sed N. P., Paba S., Radice S., Renna S., Ribaldone D. G., and Rizzuto G.
- Abstract
Background: Patients on immunosuppressive drugs have been excluded from COVID-19 vaccines trials, creating concerns regarding their efficacy. Aims: To explore the humoral response to COVID-19 vaccines in patients with inflammatory bowel disease (IBD) Methods: Effectiveness and Safety of COVID-19 Vaccine in Patients with Inflammatory Bowel Disease (IBD) Treated with Immunomodulatory or Biological Drugs (ESCAPE-IBD) is a prospective, multicentre study promoted by the Italian Group for the study of Inflammatory Bowel Disease. We present data on serological response eight weeks after the second dose of COVID-19 vaccination in IBD patients and healthy controls (HCs). Results: 1076 patients with IBD and 1126 HCs were analyzed. Seropositivity for anti-SARS-CoV-2 IgG was reported for most IBD patients, even if with a lesser rate compared with HCs (92.1% vs. 97.9%; p<0.001). HCs had higher antibody concentrations (median OD 8.72 [IQR 5.2-14-2]) compared to the whole cohort of IBD patients (median OD 1.54 [IQR 0.8-3.6]; p<0.001) and the subgroup of IBD patients (n=280) without any treatment or on aminosalicylates only (median OD 1.72 [IQR 1.0–4.1]; p<0.001). Conclusions: Although most IBD patients showed seropositivity after COVID-19 vaccines, the magnitude of the humoral response was significantly lower than in HCs. Differently from other studies, these findings seem to be mostly unrelated to the use of immune-modifying treatments (ClinicalTrials.govID:NCT04769258).
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- 2023
30. Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial
- Author
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Mariani, J, Beretta, S, Diamanti, S, Versace, A, Martini, B, Vigano, M, Castiglioni, L, Sironi, L, Carone, D, Cuccione, E, Monza, L, Giussani, C, Ferrarese, C, Mariani J., Beretta S., Diamanti S., Versace A., Martini B., Vigano M., Castiglioni L., Sironi L., Carone D., Cuccione E., Monza L., Giussani C., Ferrarese C., Mariani, J, Beretta, S, Diamanti, S, Versace, A, Martini, B, Vigano, M, Castiglioni, L, Sironi, L, Carone, D, Cuccione, E, Monza, L, Giussani, C, Ferrarese, C, Mariani J., Beretta S., Diamanti S., Versace A., Martini B., Vigano M., Castiglioni L., Sironi L., Carone D., Cuccione E., Monza L., Giussani C., and Ferrarese C.
- Abstract
Cerebral collaterals are recruited after arterial occlusion with a protective effect on tissue outcome in acute ischemic stroke. Head down tilt 15° (HDT15) is a simple, low cost and accessible procedure that could be applied as an emergency treatment, before recanalization therapies, with the aim to increase cerebral collateral flow. Spontaneously hypertensive rats have been shown to display anatomical differences in morphology and function of cerebral collaterals, compared to other rat strains, resulting in an overall poor collateral circulation. We investigate the efficacy and safety of HDT15 in spontaneously hypertensive (SHR) rats, which were considered as an animal stroke model with poor collaterals. Cerebral ischemia was induced by 90 minute endovascular occlusion of the middle cerebral artery (MCA). SHR rats were randomized to HDT15 or flat position (n = 19). HDT15 was applied 30 minutes after occlusion and lasted 60 minutes, until reperfusion. HDT15 application increased cerebral perfusion (+16.6% versus +6.1%; p = 0.0040) and resulted in a small reduction of infarct size (83.6 versus 107.1 mm3; − 21.89%; p = 0.0272), but it was not associated with early neurological improvement, compared to flat position. Our study suggests that the response to HDT15 during MCA occlusion is dependent on baseline collaterals. Nonetheless, HDT15 promoted a mild improvement of cerebral hemodynamics even in subjects with poor collaterals, without safety concerns.
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- 2023
31. Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke
- Author
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Valente, A, Mariani, J, Seminara, S, Tettamanti, M, Pignataro, G, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Diamanti, S, Vigano, M, Santangelo, F, Zoia, C, Rodriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Di Santo, C, Cuomo, O, Gullotta, G, Butti, E, Bagetta, G, Martino, G, De Simoni, M, Ferrarese, C, Fumagalli, S, Beretta, S, Valente A., Mariani J., Seminara S., Tettamanti M., Pignataro G., Perego C., Sironi L., Pedata F., Amantea D., Bacigaluppi M., Vinciguerra A., Diamanti S., Vigano M., Santangelo F., Zoia C. P., Rodriguez-Menendez V., Castiglioni L., Rzemieniec J., Dettori I., Bulli I., Coppi E., Di Santo C., Cuomo O., Gullotta G. S., Butti E., Bagetta G., Martino G., De Simoni M. -G., Ferrarese C., Fumagalli S., Beretta S., Valente, A, Mariani, J, Seminara, S, Tettamanti, M, Pignataro, G, Perego, C, Sironi, L, Pedata, F, Amantea, D, Bacigaluppi, M, Vinciguerra, A, Diamanti, S, Vigano, M, Santangelo, F, Zoia, C, Rodriguez-Menendez, V, Castiglioni, L, Rzemieniec, J, Dettori, I, Bulli, I, Coppi, E, Di Santo, C, Cuomo, O, Gullotta, G, Butti, E, Bagetta, G, Martino, G, De Simoni, M, Ferrarese, C, Fumagalli, S, Beretta, S, Valente A., Mariani J., Seminara S., Tettamanti M., Pignataro G., Perego C., Sironi L., Pedata F., Amantea D., Bacigaluppi M., Vinciguerra A., Diamanti S., Vigano M., Santangelo F., Zoia C. P., Rodriguez-Menendez V., Castiglioni L., Rzemieniec J., Dettori I., Bulli I., Coppi E., Di Santo C., Cuomo O., Gullotta G. S., Butti E., Bagetta G., Martino G., De Simoni M. -G., Ferrarese C., Fumagalli S., and Beretta S.
- Abstract
Multicentre preclinical randomized controlled trials (pRCTs) are a valuable tool to improve experimental stroke research, but are challenging and therefore underused. A common challenge regards the standardization of procedures across centres. We here present the harmonization phase for the quantification of sensorimotor deficits by composite neuroscore, which was the primary outcome of two multicentre pRCTs assessing remote ischemic conditioning in rodent models of ischemic stroke. Ischemic stroke was induced by middle cerebral artery occlusion for 30, 45 or 60 min in mice and 50, 75 or 100 min in rats, allowing sufficient variability. Eleven animals per species were video recorded during neurobehavioural tasks and evaluated with neuroscore by eight independent raters, remotely and blindly. We aimed at reaching an intraclass correlation coefficient (ICC) ≥0.60 as satisfactory interrater agreement. After a first remote training we obtained ICC = 0.50 for mice and ICC = 0.49 for rats. Errors were identified in animal handling and test execution. After a second remote training, we reached the target interrater agreement for mice (ICC = 0.64) and rats (ICC = 0.69). In conclusion, a multi-step, online harmonization phase proved to be feasible, easy to implement and highly effective to align each centre’s behavioral evaluations before project’s interventional phase.
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- 2023
32. Head down tilt 15° to preserve salvageable brain tissue in acute ischemic stroke: A pre-clinical pooled analysis, with focus on cerebral hemodynamics
- Author
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Diamanti, S, Mariani, J, Versace, A, Riva, M, Cuccione, E, Cai, R, Monza, L, Vigano, M, Bolbos, R, Chauveau, F, Cho, T, Carone, D, Ferrarese, C, Beretta, S, Diamanti S., Mariani J., Versace A., Riva M., Cuccione E., Cai R., Monza L., Vigano M., Bolbos R., Chauveau F., Cho T. -H., Carone D., Ferrarese C., Beretta S., Diamanti, S, Mariani, J, Versace, A, Riva, M, Cuccione, E, Cai, R, Monza, L, Vigano, M, Bolbos, R, Chauveau, F, Cho, T, Carone, D, Ferrarese, C, Beretta, S, Diamanti S., Mariani J., Versace A., Riva M., Cuccione E., Cai R., Monza L., Vigano M., Bolbos R., Chauveau F., Cho T. -H., Carone D., Ferrarese C., and Beretta S.
- Abstract
Neurological outcome after ischemic stroke depends on residual salvageable brain tissue at the time of recanalization. Head down tilt 15° (HDT15) was proven effective in reducing infarct size and improving functional outcome in rats with transient middle cerebral artery occlusion (t-MCAO) by increasing cerebral perfusion within the ischemic penumbra. In this pooled analysis, individual animal-level data from three experimental series were combined in a study population of 104 t-MCAO rats (45 in HDT15 group and 59 in flat position group). Co-primary outcomes were infarct size and functional outcome at 24 h in both groups. The secondary outcome was hemodynamic change induced by HDT15 in ischemic and non-ischemic hemispheres in a subgroup of animals. Infarct size at 24 h was smaller in HDT15 group than in flat position group (absolute mean difference 31.69 mm3, 95% CI 9.1–54.2, Cohen's d 0.56, p = 0.006). Functional outcome at 24 h was better in HDT15 group than in flat position group (median [IQR]: 13[10–16] vs. 11), with a shift in the distribution of the neurobehavioural scores in favour of HDT15. Mean cerebral perfusion in the ischemic hemisphere was higher during HDT15 than before its application (Perfusion Unit [P.U.], mean ± SD: 52.5 ± 19.52 P.U. vs. 41.25 ± 14.54 P.U., mean of differences 13.36, 95% CI 7.5–19.18, p = 0.0002). Mean cerebral perfusion in the non-ischemic hemisphere before and during HDT15 was unchanged (P.U., mean ± SD: 94.1 ± 33.8 P.U. vs. 100.25 ± 25.34 P.U., mean of differences 3.95, 95%, CI −1.9 to 9.6, p = 0.1576). This study confirmed that HDT15 improves the outcome in t-MCAO rats by promoting cerebral perfusion in the ischemic territory, without disrupting hemodynamics in non-ischemic areas.
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- 2023
33. Nel limite come opportunità. Competenze pedagogiche e servizi alla persona
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Gnocchi, Raffaele, Vigano', Renata Maria, raffaele gnocchi, renata maria vigano (ORCID:0000-0001-8739-7458), Gnocchi, Raffaele, Vigano', Renata Maria, raffaele gnocchi, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
Nell'orizzonte dei significati che attribuiamo alle parole spesso riscontriamo risvolti inattesi. Potenzialità, opportunità, limiti, rimandano a universi concettuali per i quali sembra assai naturale che il movimento pedaogico e i correlati pratici trovino in essi il loro luogo di esplicitazione per la realizzazione di interventi di natura preventiva o riparativa.
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- 2023
34. Knowledge and vision for a school as a safeguard of democracy
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Vigano', Renata Maria, renata maria vigano (ORCID:0000-0001-8739-7458), Vigano', Renata Maria, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
A fronte della complessità della questione scolastica, il discorso su quest’ultima è spesso superficiale e non attinge né a una sua conoscenza approfondita suffragata da dati autorevoli e competenze scientifiche né a una visione del ruolo imprescindibile della scuola nella promozione e salvaguardia della democrazia. Il contributo esamina perciò un insieme di evidenze poste in luce da autorevoli indagini e da fonti statistiche nazionali e internazionali da cui risaltano molteplici criticità persistenti nel sistema di istruzione e formazione del nostro Paese il quale non riesce ad assolvere quanto sancito dalla Costituzione e rischia anzi di farsi ulteriore veicolo di discriminazione sociale. Approda pertanto a delineare alcune direzioni di impegno prioritario per ridare valore alla scuola come leva di una società democratica: ritessere il tessuto valoriale, dare fiducia alla scuola, coltivare la cultura valutativa, dare centralità educativa ai luoghi della formazione., In the face of the complexity of the school question, the discourse on the latter is often superficial and draws neither on its in-depth knowledge supported by authoritative data and scientific expertise nor on a vision of the essential role of the school in promoting and safeguarding democracy. The paper therefore examines a set of evidence highlighted by national and international authoritative surveys and statistical sources from which many persistent critical issues stand out in the education and training system of our country, which fails to fulfill what is enshrined in our Constitution and indeed risks becoming a further vehicle of social discrimination. The Author therefore outlines some directions of priority commitment to restore value to the school as a lever of a democratic society: reweave the fabric of values, trust the school, cultivate the culture of evaluation, give educational centrality to school.
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- 2023
35. Evaluation as a Keystone of the Teaching Profession
- Author
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Vigano', Renata Maria, renata maria vigano (ORCID:0000-0001-8739-7458), Vigano', Renata Maria, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
L’insegnamento è riconosciuto come professione in molti Paesi che hanno adottato sistemi formativi pubblici strutturati. Restano in realtà alcuni aspetti non del tutto perimetrati sul piano del riconoscimento concettuale e organizzativo, per esempio la distinzione fra professionalità e professionismo, le rivendicazioni sociali delle associazioni di insegnanti in nome dell’autonomia professionale, i dibattiti riguardo alla definizione delle conoscenze e delle competenze che costituiscono il profilo professionale. In questo quadro in parte delineato e in parte incerto si situa anche la valutazione degli apprendimenti come attività svolta dagli insegnanti. Il presente contributo la esamina nella prospettiva del suo ruolo in relazione alla professionalità e alla professionalizzazione docente e sviluppa l’ipotesi che essa ne sia la chiave di volta. Esaminando le intricate dinamiche delle pratiche di valutazione degli insegnanti, questo studio evidenzia il potere trasformativo della valutazione nel plasmare la professione docente e nel promuovere l’eccellenza educativa. La ricerca fornisce intuizioni sulla natura sfaccettata della professione e sottolinea il ruolo critico svolto dalla valutazione nel favorire la crescita professionale e migliorare i risultati di apprendimento degli studenti., Teaching is recognized as a profession in many countries that have adopted structured public education systems. There are, in fact, some aspects that lack clear conceptual and organizational recognition, such as: the distinction between professionalism and professional style, the social demands of teachers’ associations in the name of professional autonomy, ongoing discussions on the definition of the knowledge and skills that constitute the professional profile. This paper explores how teachers’ assessment of learning contributes to the overall context, and it does so with a perspective on the pivotal role of teachers’ assessment in relation to professionalism and teacher professionalization. By examining the intricate dynamics of teachers’ assessment practices, it illuminates the transformative power of evaluation in shaping the teaching profession and driving educational excellence. The study provides valuable insights into the multifaceted nature of professionalism and underscores the critical role played by assessment in fostering professional growth and enhancing student learning outcomes.
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- 2023
36. The role of the school context in teachers' beliefs about formative assessment during the Emergency Remote Teaching
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Giganti, Marco, Vigano', Renata Maria, Marco Giganti (ORCID:0000-0002-3120-8344), Renata Vigano' (ORCID:0000-0001-8739-7458), Giganti, Marco, Vigano', Renata Maria, Marco Giganti (ORCID:0000-0002-3120-8344), and Renata Vigano' (ORCID:0000-0001-8739-7458)
- Abstract
Il contributo verte su un’indagine osservativo-descrittiva su tre istituti omnicomprensivi della Regione Lombardia avente per oggetti: il contesto in cui gli insegnanti hanno operato durante il Covid-19, le loro convinzioni e dichiarazioni di prassi sulla valutazione formativa, l'apprendimento e il coinvolgimento degli studenti durante l'ERT, i legami tra queste e il contesto. L’indagine suggerisce che gli insegnanti sono convinti che la valutazione formativa possa sostenere l'apprendimento e l'impegno degli studenti in un contesto considerato emergenziale. Dai dati raccolti emerge una correlazione positiva tra convinzioni e pratiche e un effetto significativo del contesto scolastico sulla costruzione di queste ultime., The focus of the paper is an observational-descriptive study of three comprehensive schools in the Lombardy Region. It examines: the context in which teachers worked during the COVID-19 pandemic, their beliefs and practices regarding formative assessment, student learning and engagement during ERT, and the links between these and the context. The study suggests that there is a belief among teachers that formative assessment can support student learning and engagement in what is perceived to be an emergency context. The data collected indicate a positive correlation between beliefs and practices. There is also a significant effect of the school context on the development of the latter.
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- 2023
37. Evaluation and Quality of Education. Which Point of Arrival?
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Vigano', Renata Maria, renata maria vigano (ORCID:0000-0001-8739-7458), Vigano', Renata Maria, and renata maria vigano (ORCID:0000-0001-8739-7458)
- Abstract
Il rapporto tra valutazione e qualità è intrinseco: la qualità per essere percepita è sempre apprezzata ossia, almeno per via implicita, misurata e valutata; nella sua risonanza sociale la valutazione è attesa come processo che sfocia in un giudizio di qualità e in una direzione di miglioramento di ciò che valuta. Il concetto di qualità sfugge in sé a una perimetrazione uniforme e definitiva giacché si sostanzia anche delle visioni e delle attese variabili dei soggetti implicati. Il contributo ripercorre l’itinerario del concetto di valutazione che da atto puntuale, per lo più esercitato in piena autonomia dal valutatore, ha assunto nel tempo la caratteristica di un àmbito in cui coabitano soggetti e dimensioni diverse, a elevata significazione sociale. Ciò condiziona il rapporto tra valutazione e qualità e genera questioni di rilievo sotto il profilo pedagogico e metodologico oltre che sociale ed etico, sino a far emergere l’ipotesi di redistribuire la responsabilità valutativa tra scuola e società nell’articolazione di tutti i suoi attori, The relationship between evaluation and quality is intrinsic: quality to be perceived is always appreciated, that is, at least implicitly, measured and evaluated; in its social resonance evaluation is expected as a process that leads to a judgment of quality and a direction of improvement of what it evaluates. The concept of quality in itself escapes a uniform and definitive delimitation since it is also substantiated by the variable visions and expectations of the subjects involved. The paper traces the itinerary of the concept of evaluation that from a punctual act, mostly exercised in full autonomy by the evaluator, over time has assumed the characteristic of an area in which different subjects and dimensions coexist, with a high social significance. This conditions the relationship between evaluation and quality and generates important issues from a pedagogical and methodological as well as social and ethical point of view, to the point of bringing out the hypothesis of redistributing the evaluation responsibility between school and society in the articulation of all its actors.
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- 2023
38. Combined Motor and Cognitive Rehabilitation: The Impact on Motor Performance in Patients with Mild Cognitive Impairment. Systematic Review and Meta-Analysis
- Author
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Kiper, P, Richard, M, Stefanutti, F, Pierson-Poinsignon, R, Cacciante, L, Perin, C, Mazzucchelli, M, Vigano, B, Meroni, R, Kiper P., Richard M., Stefanutti F., Pierson-Poinsignon R., Cacciante L., Perin C., Mazzucchelli M., Vigano B., Meroni R., Kiper, P, Richard, M, Stefanutti, F, Pierson-Poinsignon, R, Cacciante, L, Perin, C, Mazzucchelli, M, Vigano, B, Meroni, R, Kiper P., Richard M., Stefanutti F., Pierson-Poinsignon R., Cacciante L., Perin C., Mazzucchelli M., Vigano B., and Meroni R.
- Abstract
Mild cognitive impairment (MCI), a neurodegenerative disease leading to Alzheimer’s disease or dementia, is often associated with physical complaints. Combined physical and cognitive training (PCT) has been investigated to see the effects on cognitive function, but its impact on motor functions and activities of daily living has not been explored yet. The combination of physical and cognitive training may be a valuable non-pharmacological intervention that could preserve motor function and quality of life (QoL). We aimed, therefore, to analyze if combined PCT is effective at improving motor performance in patients with an MCI. A systematic electronic literature search and a meta-analysis were conducted. The following criteria were compulsory for inclusion in the study: (1) randomized controlled trial design; (2) combined PCT compared to motor training alone or no intervention; (3) motor outcomes as a study’s end point. Nine articles met the inclusion criteria. Results showed that PCT significantly enhances balance compared to motor training alone (SMD 0.56; 95% CI 0.07 to 1.06; I2 = 59%; 160 participants), whereas a significant improvement was found for mobility in the PCT group when compared to no intervention (MD −1.80; 95% CI −2.70 to −0.90; I2 = 0%; 81 participants). However, there is no evidence that people with MCI experience an increase in gait speed and QoL at the end of their practice sessions. Further investigation with larger samples and a longer period of monitoring after intervention should be undertaken.
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- 2022
39. Predictors of serious adverse events and non-response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid
- Author
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De Vincentis, A, D'Amato, D, Cristoferi, L, Gerussi, A, Malinverno, F, Lleo, A, Colapietro, F, Marra, F, Galli, A, Fiorini, C, Coco, B, Brunetto, M, Niro, G, Cotugno, R, Saitta, C, Cozzolongo, R, Losito, F, Giannini, E, Labanca, S, Marzioni, M, Marconi, G, Morgando, A, Pellicano, R, Vanni, E, Cazzagon, N, Floreani, A, Chessa, L, Morelli, O, Muratori, L, Pellicelli, A, Pompili, M, Ponziani, F, Tortora, A, Rosina, F, Russello, M, Cannavo, M, Simone, L, Storato, S, Vigano, M, Abenavoli, L, D'Anto, M, De Gasperi, E, Distefano, M, Scifo, G, Zolfino, T, Calvaruso, V, Cuccorese, G, Palitti, V, Sacco, R, Bertino, G, Frazzetto, E, Alvaro, D, Mulinacci, G, Palermo, A, Scaravaglio, M, Terracciani, F, Galati, G, Ronca, V, Zuin, M, Claar, E, Izzi, A, Picardi, A, Invernizzi, P, Vespasiani-Gentilucci, U, Carbone, M, Feletti, V, Mussetto, A, Venere, R, Bernaccioni, G, Graciella Pigozzi, M, Fagiuoli, S, Terreni, N, Pozzoni, P, Baiocchi, L, Grassi, G, Vinci, M, Bellia, V, Boldizzoni, R, Casella, S, Omazzi, B, Poggi, G, De Vincentis A., D'Amato D., Cristoferi L., Gerussi A., Malinverno F., Lleo A., Colapietro F., Marra F., Galli A., Fiorini C., Coco B., Brunetto M., Niro G. A., Cotugno R., Saitta C., Cozzolongo R., Losito F., Giannini E. G., Labanca S., Marzioni M., Marconi G., Morgando A., Pellicano R., Vanni E., Cazzagon N., Floreani A., Chessa L., Morelli O., Muratori L., Pellicelli A., Pompili M., Ponziani F., Tortora A., Rosina F., Russello M., Cannavo M., Simone L., Storato S., Vigano M., Abenavoli L., D'Anto M., De Gasperi E., Distefano M., Scifo G., Zolfino T., Calvaruso V., Cuccorese G., Palitti V. P., Sacco R., Bertino G., Frazzetto E., Alvaro D., Mulinacci G., Palermo A., Scaravaglio M., Terracciani F., Galati G., Ronca V., Zuin M., Claar E., Izzi A., Picardi A., Invernizzi P., Vespasiani-Gentilucci U., Carbone M., Feletti V., Mussetto A., Venere R., Bernaccioni G., Graciella Pigozzi M., Fagiuoli S., Terreni N., Pozzoni P., Baiocchi L., Grassi G., Vinci M., Bellia V., Boldizzoni R., Casella S., Omazzi B., Poggi G., De Vincentis, A, D'Amato, D, Cristoferi, L, Gerussi, A, Malinverno, F, Lleo, A, Colapietro, F, Marra, F, Galli, A, Fiorini, C, Coco, B, Brunetto, M, Niro, G, Cotugno, R, Saitta, C, Cozzolongo, R, Losito, F, Giannini, E, Labanca, S, Marzioni, M, Marconi, G, Morgando, A, Pellicano, R, Vanni, E, Cazzagon, N, Floreani, A, Chessa, L, Morelli, O, Muratori, L, Pellicelli, A, Pompili, M, Ponziani, F, Tortora, A, Rosina, F, Russello, M, Cannavo, M, Simone, L, Storato, S, Vigano, M, Abenavoli, L, D'Anto, M, De Gasperi, E, Distefano, M, Scifo, G, Zolfino, T, Calvaruso, V, Cuccorese, G, Palitti, V, Sacco, R, Bertino, G, Frazzetto, E, Alvaro, D, Mulinacci, G, Palermo, A, Scaravaglio, M, Terracciani, F, Galati, G, Ronca, V, Zuin, M, Claar, E, Izzi, A, Picardi, A, Invernizzi, P, Vespasiani-Gentilucci, U, Carbone, M, Feletti, V, Mussetto, A, Venere, R, Bernaccioni, G, Graciella Pigozzi, M, Fagiuoli, S, Terreni, N, Pozzoni, P, Baiocchi, L, Grassi, G, Vinci, M, Bellia, V, Boldizzoni, R, Casella, S, Omazzi, B, Poggi, G, De Vincentis A., D'Amato D., Cristoferi L., Gerussi A., Malinverno F., Lleo A., Colapietro F., Marra F., Galli A., Fiorini C., Coco B., Brunetto M., Niro G. A., Cotugno R., Saitta C., Cozzolongo R., Losito F., Giannini E. G., Labanca S., Marzioni M., Marconi G., Morgando A., Pellicano R., Vanni E., Cazzagon N., Floreani A., Chessa L., Morelli O., Muratori L., Pellicelli A., Pompili M., Ponziani F., Tortora A., Rosina F., Russello M., Cannavo M., Simone L., Storato S., Vigano M., Abenavoli L., D'Anto M., De Gasperi E., Distefano M., Scifo G., Zolfino T., Calvaruso V., Cuccorese G., Palitti V. P., Sacco R., Bertino G., Frazzetto E., Alvaro D., Mulinacci G., Palermo A., Scaravaglio M., Terracciani F., Galati G., Ronca V., Zuin M., Claar E., Izzi A., Picardi A., Invernizzi P., Vespasiani-Gentilucci U., Carbone M., Feletti V., Mussetto A., Venere R., Bernaccioni G., Graciella Pigozzi M., Fagiuoli S., Terreni N., Pozzoni P., Baiocchi L., Grassi G., Vinci M., Bellia V., Boldizzoni R., Casella S., Omazzi B., and Poggi G.
- Abstract
Background & Aims: Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with “advanced cirrhosis” because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy. Methods: Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs). Results: One hundred PBC cirrhotics were included, 97 Child-Pugh class A and 3 class B. Thirty-one had oesophageal varices and 5 had a history of ascites. Thirty-three per cent and 32% of patients achieved a biochemical response at 6 and 12 months respectively. Male sex (adjusted-RR 1.75, 95%CI 1.42–2.12), INR (1.37, 1.00–1.87), Child-Pugh score (1.79, 1.28–2.50), MELD (1.17, 1.04–1.30) and bilirubin (1.83, 1.11–3.01) were independently associated with non-response to OCA. Twenty-two patients discontinued OCA within 12 months: 10 for pruritus, 9 for hepatic SAEs (5 for jaundice and/or ascitic decompensation; 4 for upper digestive bleeding). INR (adjusted-RR 1.91, 95%CI 1.10–3.36), lower albumin levels (0.18, 0.06–0.51), Child-Pugh score (2.43, 1.50–4.04), history of ascites (3.5, 1.85–6.5) and bilirubin (1.30, 1.05–1.56), were associated with hepatic SAEs. A total bilirubin≥1.4 mg/dl at baseline was the most accurate biochemical predictor of hepatic SAEs under OCA. Conclusions: An accurate baseline assessment is crucial to select cirrhotic patients who can benefit from OCA. Although OCA is effective in one third of cirrhotics, bilirubin level ≥1.4 mg/dl should discourage from its use.
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- 2022
40. Open versus laparoscopic gastrectomy for advanced gastric cancer: a propensity score matching analysis of survival in a western population—on behalf of the Italian Research Group for Gastric Cancer
- Author
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Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., Uccelli M., Lombardi, P, Bernasconi, D, Baiocchi, G, Berselli, M, Biondi, A, Castoro, C, Catarci, M, Degiuli, M, Fumagalli Romario, U, Giacopuzzi, S, Marchesi, F, Marrelli, D, Mazzola, M, Molfino, S, Olmi, S, Rausei, S, Rosa, F, Rosati, R, Roviello, F, Santi, S, Solaini, L, Staderini, F, Vigano, J, Ferrari, G, Agnes, A, Alfieri, S, Alloggio, M, Bencivenga, M, Benedetti, M, Bottari, A, Cianchi, F, Cocozza, E, Dalmonte, G, De Martini, P, De Pascale, S, Desio, M, Emiliani, G, Ercolani, G, Galli, F, Garosio, I, Giani, A, Gualtierotti, M, Marano, L, Morgagni, P, Peri, A, Puccetti, F, Reddavid, R, Uccelli, M, Lombardi P. M., Bernasconi D., Baiocchi G. L., Berselli M., Biondi A., Castoro C., Catarci M., Degiuli M., Fumagalli Romario U., Giacopuzzi S., Marchesi F., Marrelli D., Mazzola M., Molfino S., Olmi S., Rausei S., Rosa F., Rosati R., Roviello F., Santi S., Solaini L., Staderini F., Vigano J., Ferrari G., Agnes A., Alfieri S., Alloggio M., Bencivenga M., Benedetti M., Bottari A., Cianchi F., Cocozza E., Dalmonte G., De Martini P., De Pascale S., Desio M., Emiliani G., Ercolani G., Galli F., Garosio I., Giani A., Gualtierotti M., Marano L., Morgagni P., Peri A., Puccetti F., Reddavid R., and Uccelli M.
- Abstract
Background: Oncologic outcomes after laparoscopic gastrectomy for advanced gastric cancer in the West have been poorly investigated. The aim of the present study was to compare survival outcomes in patients undergoing curative-intent laparoscopic and open gastrectomy for advanced gastric cancer in several centres belonging to the Italian Research Group for Gastric Cancer. Methods: Data of patients operated between 2015 and 2018 were retrospectively analysed. Propensity Score Matching was performed to balance baseline characteristics of patients undergoing laparoscopic and open gastrectomy. The primary endpoint was 3-year overall survival. Secondary endpoints were 3-year disease-free survival and short-term outcomes. Multivariable regression analyses for survival were conducted. Results: Data were retrieved from 20 centres. Of the 717 patients included, 438 patients were correctly matched, 219 per group. The 3-year overall survival was 73.6% and 68.7% in the laparoscopic and open group, respectively (p = 0.40). When compared with open gastrectomy, laparoscopic gastrectomy showed comparable 3-year disease-free survival (62.8%, vs 58.9%, p = 0.40), higher rate of return to intended oncologic treatment (56.9% vs 40.2%, p = 0.001), similar 30-day morbidity/mortality. Prognostic factors for survival were ASA Score ≥ 3, age-adjusted Charlson Comorbidity Index ≥ 5, lymph node ratio ≥ 0.15, p/ypTNM Stage III and return to intended oncologic treatment. Conclusions: Laparoscopic gastrectomy for advanced gastric cancer offers similar rates of survival when compared to open gastrectomy, with higher rates of return to intended oncologic treatment. ASA score, age-adjusted Charlson Comorbidity Index, lymph node ratio, return to intended oncologic treatment and p/ypTNM Stage, but not surgical approach, are prognostic factors for survival.
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- 2022
41. T2*-Weighted Imaging Performance in the Detection of Deep Endometriosis among Readers with Different Experience: Comparison with Conventional MRI Sequences
- Author
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Franco, P, Annibali, S, Vigano, S, Cazzella, C, Marra, C, Smedile, A, Bonaffini, P, Marra, P, Garcia, M, Reinhold, C, Sironi, S, Franco P. N., Annibali S., Vigano S., Cazzella C., Marra C., Smedile A., Bonaffini P. A., Marra P., Garcia M. M. O., Reinhold C., Sironi S., Franco, P, Annibali, S, Vigano, S, Cazzella, C, Marra, C, Smedile, A, Bonaffini, P, Marra, P, Garcia, M, Reinhold, C, Sironi, S, Franco P. N., Annibali S., Vigano S., Cazzella C., Marra C., Smedile A., Bonaffini P. A., Marra P., Garcia M. M. O., Reinhold C., and Sironi S.
- Abstract
Magnetic resonance imaging (MRI) is an effective technique for the diagnosis and preoperative staging of deep infiltrative endometriosis (DIE). The usefulness of MRI sequences susceptible to chronic blood degradation products, such as T2*-weighted imaging, remains uncertain. The present study aims to evaluate the diagnostic performance of these sequences in addition to the conventional protocol for DIE assessment. Forty-four MRI examinations performed for clinical and/or ultrasound DIE suspicion were evaluated by three readers with variable experience in female imaging. The inter-observer agreement between the reader who analysed only the conventional protocol and the one who also considered T2*-weighted sequences was excellent. The less experienced reader diagnosed a significantly higher number of endometriosis foci on the T2*-weighted sequences compared with the most experienced observer. T2*-weighted sequences do not seem to provide significant added value in the evaluation of DIE, especially in less experienced readers. Furthermore, artifacts caused by undesirable sources of magnetic inhomogeneity may lead to overdiagnosis.
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- 2022
42. Systematic review-Pancreatic involvement in inflammatory bowel disease
- Author
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Massironi, S, Fanetti, I, Vigano, C, Pirola, L, Fichera, M, Cristoferi, L, Capurso, G, Invernizzi, P, Danese, S, Massironi, Sara, Fanetti, Ilaria, Vigano, Chiara, Pirola, Lorena, Fichera, Maria, Cristoferi, Laura, Capurso, Gabriele, Invernizzi, Pietro, Danese, Silvio, Massironi, S, Fanetti, I, Vigano, C, Pirola, L, Fichera, M, Cristoferi, L, Capurso, G, Invernizzi, P, Danese, S, Massironi, Sara, Fanetti, Ilaria, Vigano, Chiara, Pirola, Lorena, Fichera, Maria, Cristoferi, Laura, Capurso, Gabriele, Invernizzi, Pietro, and Danese, Silvio
- Abstract
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory immune-mediated disorder of the gut with frequent extra-intestinal complications. Pancreatic involvement in IBD is not uncommon and comprises a heterogeneous group of conditions, including acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP) and pancreatic exocrine insufficiency (PEI); however, data on such an association remain sparse and heterogeneous. Method: PubMed/MEDLINE and EMBASE databases were searched for studies investigating pancreatic involvement in patients with IBD. Results: Four thousand one hundred and twenty-one records were identified and 547 screened; finally, 124 studies were included in the review. AP is the most frequent pancreatic manifestation in IBD; the majority of AP cases in IBD are due to gallstones and drugs but cases of idiopathic AP are increasingly reported. AIP is a rare disease, but a strong association with IBD has been demonstrated, especially for type 2 and ulcerative colitis. The pathogenetic link between IBD and AIP remains unclear, but an immune-mediated pathway seems plausible. An association between CP and PEI with IBD has also been suggested, but data are to date scarce and conflicting. Conclusion: This is the first systematic review of the association between IBD and pancreatic diseases. Gallstones and drugs should be considered the most probable causes of AP in IBD, with type 2 AIP also being possible.
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- 2022
43. Insomnia and related factors in patients with pre-existing psychiatric disorders compared to the general population during the COVID-19 lockdown: Findings from the multicentric COMET study
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Dell'Osso, B, Vigano, C, Conti, D, Scarpa, C, Casati, L, Albert, U, Carmassi, C, Carra, G, Cirulli, F, Nanni, M, Pompili, M, Sampogna, G, Sani, G, Tortorella, A, Volpe, U, Fiorillo, A, Dell'Osso B., Vigano C., Conti D., Scarpa C., Casati L., Albert U., Carmassi C., Carra G., Cirulli F., Nanni M. G., Pompili M., Sampogna G., Sani G., Tortorella A., Volpe U., Fiorillo A., Dell'Osso, B, Vigano, C, Conti, D, Scarpa, C, Casati, L, Albert, U, Carmassi, C, Carra, G, Cirulli, F, Nanni, M, Pompili, M, Sampogna, G, Sani, G, Tortorella, A, Volpe, U, Fiorillo, A, Dell'Osso B., Vigano C., Conti D., Scarpa C., Casati L., Albert U., Carmassi C., Carra G., Cirulli F., Nanni M. G., Pompili M., Sampogna G., Sani G., Tortorella A., Volpe U., and Fiorillo A.
- Abstract
Background: The COVID-19 pandemic has heavily impacted social, economic and health systems worldwide. Necessary confinement measures have, in turn, contributed to the occurrence of several stress-related conditions and deterioration of pre-existing mental conditions, including insomnia. Objective: The present study sought to investigate the occurrence and severity of insomnia during the COVID-19 lockdown among psychiatric patients and in the general population in the largest Italian sample examined to date. Potential factors associated with a risk of developing insomnia in the global sample were examined as well. Methods: A sample of 20,720 people (5.5% of them being psychiatric patients) was assessed through an online survey conducted during lockdown between March and May 2020. To investigate the occurrence and severity of sleep related issues, the Insomnia Severity Index (ISI) was used. In order to evaluate factors associated with the severity of insomnia in the global sample, multivariate linear regression models were performed. Results: During the lockdown, patients with pre-existing mental disorders reported a mean higher score on the ISI scale (p < 0.001) compared to the general population. According to the multivariate regression models, the first three weeks of lockdown were significantly associated with a higher risk of insomnia, but the risk disappeared in the fourth week. Other associated factors included: the presence of a pre-existing mental disorder, ages 24 to 64 years old, and/or being female (p < 0.001). Conclusions: Although containment measures represent essential public health strategies to avoid the spread of the COVID-19 pandemic, sleep was one of the aspects affected during the early stages of the lockdown in both people with pre-existing mental disorders and general population. As an integral part of COVID-19 intervention, it is useful to raise awareness about these issues and to adopt both preventive and therapeutic interventions.
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- 2022
44. Qubic: the q and u bolometric interferometer for cosmology
- Author
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Zmuidzinas, J, Gao, JR, Piat, M, Battistelli, E, De Bernardis, P, Dalessandro, G, De Petris, M, Grandsire, L, Hamilton, J, Hoang, T, Marnieros, S, Masi, S, Mennella, A, Mousset, L, Osullivan, C, Prele, D, Stankowiak, G, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Belier, B, Bau, A, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, Garcia, B, Garcia Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versille, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivicri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Vigano, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, Piat M., Battistelli E. S., De Bernardis P., Dalessandro G., De Petris M., Grandsire L., Hamilton J. -C., Hoang T. D., Marnieros S., Masi S., Mennella A., Mousset L., Osullivan C., Prele D., Stankowiak G., Tartari A., Thermeau J. -P., Torchinsky S. A., Voisin F., Zannoni M., Ade P., Alberro J. G., Almela A., Amico G., Arnaldi L. H., Auguste D., Aumont J., Azzoni S., Banfi S., Belier B., Bau A., Bennett D., Berge L., Bernard J. -Ph., Bersanelli M., Bigot-Sazy M. -A., Bonaparte J., Bonis J., Bunn E., Burke D., Buzi D., Cavaliere F., Chanial P., Chapron C., Charlassier R., Cobos Cerutti A. C., Columbro F., Coppolecchia A., De Gasperis G., De Leo M., Dheilly S., Duca C., Dumoulin L., Etchegoyen A., Fasciszewski A., Ferreyro L. P., Fracchia D., Franceschet C., Gamboa Lerena M. M., Ganga K. M., Garcia B., Garcia Redondo M. E., Gaspard M., Gayer D., Gervasi M., Giard M., Gilles V., Giraud-Heraud Y., Gomez Berisso M., Gonzalez M., Gradziel M., Hampel M. R., Harari D., Henrot-Versille S., Incardona F., Jules E., Kaplan J., Kristukat C., Lamagna L., Loucatos S., Louis T., Maffei B., Marty W., Mattei A., May A., McCulloch M., Mele L., Melo D., Montier L., Mundo L. M., Murphy J. A., Murphy J. D., Nati F., Olivicri E., Oriol C., Paiella A., Pajot F., Passerini A., Pastoriza H., Pelosi A., Perbost C., Perciballi M., Pezzotta F., Piacentini F., Piccirillo L., Pisano G., Platino M., Polenta G., Puddu R., Rambaud D., Rasztocky E., Ringegni P., Romero G. E., Salum J. M., Schillaci A., Scoccola C. G., Scully S., Spinelli S., Stolpovskiy M., Supanitsky A. D., Timbie P., Tomasi M., Tucker C., Tucker G., Vigano D., Vittorio N., Wicek F., Wright M., Zullo A., Zmuidzinas, J, Gao, JR, Piat, M, Battistelli, E, De Bernardis, P, Dalessandro, G, De Petris, M, Grandsire, L, Hamilton, J, Hoang, T, Marnieros, S, Masi, S, Mennella, A, Mousset, L, Osullivan, C, Prele, D, Stankowiak, G, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Belier, B, Bau, A, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, Garcia, B, Garcia Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versille, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivicri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Vigano, D, Vittorio, N, Wicek, F, Wright, M, Zullo, A, Piat M., Battistelli E. S., De Bernardis P., Dalessandro G., De Petris M., Grandsire L., Hamilton J. -C., Hoang T. D., Marnieros S., Masi S., Mennella A., Mousset L., Osullivan C., Prele D., Stankowiak G., Tartari A., Thermeau J. -P., Torchinsky S. A., Voisin F., Zannoni M., Ade P., Alberro J. G., Almela A., Amico G., Arnaldi L. H., Auguste D., Aumont J., Azzoni S., Banfi S., Belier B., Bau A., Bennett D., Berge L., Bernard J. -Ph., Bersanelli M., Bigot-Sazy M. -A., Bonaparte J., Bonis J., Bunn E., Burke D., Buzi D., Cavaliere F., Chanial P., Chapron C., Charlassier R., Cobos Cerutti A. C., Columbro F., Coppolecchia A., De Gasperis G., De Leo M., Dheilly S., Duca C., Dumoulin L., Etchegoyen A., Fasciszewski A., Ferreyro L. P., Fracchia D., Franceschet C., Gamboa Lerena M. M., Ganga K. M., Garcia B., Garcia Redondo M. E., Gaspard M., Gayer D., Gervasi M., Giard M., Gilles V., Giraud-Heraud Y., Gomez Berisso M., Gonzalez M., Gradziel M., Hampel M. R., Harari D., Henrot-Versille S., Incardona F., Jules E., Kaplan J., Kristukat C., Lamagna L., Loucatos S., Louis T., Maffei B., Marty W., Mattei A., May A., McCulloch M., Mele L., Melo D., Montier L., Mundo L. M., Murphy J. A., Murphy J. D., Nati F., Olivicri E., Oriol C., Paiella A., Pajot F., Passerini A., Pastoriza H., Pelosi A., Perbost C., Perciballi M., Pezzotta F., Piacentini F., Piccirillo L., Pisano G., Platino M., Polenta G., Puddu R., Rambaud D., Rasztocky E., Ringegni P., Romero G. E., Salum J. M., Schillaci A., Scoccola C. G., Scully S., Spinelli S., Stolpovskiy M., Supanitsky A. D., Timbie P., Tomasi M., Tucker C., Tucker G., Vigano D., Vittorio N., Wicek F., Wright M., and Zullo A.
- Abstract
QUBIC (Q and U bolometric interferometer for cosmology) is an international ground-based experiment dedicated to the measurement of the polarized fluctuations of the cosmic microwave background (CMB). It is based on bolometric interferometry, an original detection technique which combines the immunity to systematic effects of an interferometer with the sensitivity of low temperature incoherent detectors. QUBIC will be deployed in Argentina, at the Alto Chorrillos mountain site near San Antonio de los Cobres, in the Salta province. The QUBIC detection chain consists of 2048 NbSi transition edge sensors (TESs) cooled to 320 mK. The voltage-biased TESs are read out with time domain multiplexing based on superconducting quantum interference devices (SQUIDs) at 1 K and a novel SiGe application-specific integrated circuit (ASIC) at 60 K allowing an unprecedented multiplexing (MUX) factor equal to 128 to be reached. The current QUBIC version is based on a reduced number of detectors (1/4) in order to validate the detection technique. The QUBIC experiment is currently being validated in the lab in Salta (Argentina) before going to the site for observations. This paper presents the main results of the characterization phase with a focus on the detectors and readout system.
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- 2022
45. Current practice on the use of prophylactic drain after gastrectomy in Italy: the Abdominal Drain in Gastrectomy (ADiGe) survey
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Mengardo, V, Weindelmayer, J, Veltri, A, Giacopuzzi, S, Torroni, L, de Manzoni, G, Agresta, F, Alfieri, R, Alfieri, S, Antonacci, N, Baiocchi, G, Bencini, L, Bencivenga, M, Benedetti, M, Berselli, M, Biondi, A, Capolupo, G, Carboni, F, Casadei, R, Casella, F, Catarci, M, Cerri, P, Chiari, D, Cocozza, E, Colombo, G, Cozzaglio, L, Dalmonte, G, Degiuli, M, De Luca, M, De Luca, R, De Manzini, N, De Pasqual, C, De Pascale, S, De Ruvo, N, Di Cosmo, M, Di Leo, A, Di Paola, M, Elio, A, Ferrara, F, Ferrari, G, Fiscon, V, Fumagalli, U, Garulli, G, Gennai, A, Gentile, I, Germani, P, Gualtierotti, M, Guerini, F, Gurrado, A, Inama, M, La Torre, F, Laterza, E, Losurdo, P, Macri, A, Marano, A, Marano, L, Marchesi, F, Marino, F, Massani, M, Menghi, R, Milone, M, Molfino, S, Montuori, M, Moretto, G, Morgagni, P, Morpurgo, E, Abdallah, M, Nespoli, L, Olmi, S, Palaia, R, Pallabazer, G, Parise, P, Pasculli, A, Pericoli Ridolfini, M, Pesce, A, Pinotti, E, Pisano, M, Poiasina, E, Postiglione, V, Rausei, S, Rella, A, Rosa, F, Rosati, R, Rossi, G, Rossit, L, Rovatti, M, Ruspi, L, Sacco, L, Saladino, E, Sansonetti, A, Sartori, A, Scaglione, D, Scaringi, S, Schoenthaler, C, Sena, G, Simone, M, Solaini, L, Strignano, P, Tartaglia, N, Testa, S, Testini, M, Tiberio, G, Treppiedi, E, Vagliasindi, A, Valmasoni, M, Vigano, J, Zanchettin, G, Zanoni, A, Zardini, C, Zerbinati, A, Mengardo V., Weindelmayer J., Veltri A., Giacopuzzi S., Torroni L., de Manzoni G., Agresta F., Alfieri R., Alfieri S., Antonacci N., Baiocchi G. L., Bencini L., Bencivenga M., Benedetti M., Berselli M., Biondi A., Capolupo G. T., Carboni F., Casadei R., Casella F., Catarci M., Cerri P., Chiari D., Cocozza E., Colombo G., Cozzaglio L., Dalmonte G., Degiuli M., De Luca M., De Luca R., De Manzini N., De Pasqual C. A., De Pascale S., De Ruvo N., Di Cosmo M., Di Leo A., Di Paola M., Elio A., Ferrara F., Ferrari G., Fiscon V., Fumagalli U., Garulli G., Gennai A., Gentile I., Germani P., Gualtierotti M., Guerini F., Gurrado A., Inama M., La Torre F., Laterza E., Losurdo P., Macri A., Marano A., Marano L., Marchesi F., Marino F., Massani M., Menghi R., Milone M., Molfino S., Montuori M., Moretto G., Morgagni P., Morpurgo E., Abdallah M., Nespoli L., Olmi S., Palaia R., Pallabazer G., Parise P., Pasculli A., Pericoli Ridolfini M., Pesce A., Pinotti E., Pisano M., Poiasina E., Postiglione V., Rausei S., Rella A., Rosa F., Rosati R., Rossi G., Rossit L., Rovatti M., Ruspi L., Sacco L., Saladino E., Sansonetti A., Sartori A., Scaglione D., Scaringi S., Schoenthaler C., Sena G., Simone M., Solaini L., Strignano P., Tartaglia N., Testa S., Testini M., Tiberio G. A. M., Treppiedi E., Vagliasindi A., Valmasoni M., Vigano J., Zanchettin G., Zanoni A., Zardini C., Zerbinati A., Mengardo, V, Weindelmayer, J, Veltri, A, Giacopuzzi, S, Torroni, L, de Manzoni, G, Agresta, F, Alfieri, R, Alfieri, S, Antonacci, N, Baiocchi, G, Bencini, L, Bencivenga, M, Benedetti, M, Berselli, M, Biondi, A, Capolupo, G, Carboni, F, Casadei, R, Casella, F, Catarci, M, Cerri, P, Chiari, D, Cocozza, E, Colombo, G, Cozzaglio, L, Dalmonte, G, Degiuli, M, De Luca, M, De Luca, R, De Manzini, N, De Pasqual, C, De Pascale, S, De Ruvo, N, Di Cosmo, M, Di Leo, A, Di Paola, M, Elio, A, Ferrara, F, Ferrari, G, Fiscon, V, Fumagalli, U, Garulli, G, Gennai, A, Gentile, I, Germani, P, Gualtierotti, M, Guerini, F, Gurrado, A, Inama, M, La Torre, F, Laterza, E, Losurdo, P, Macri, A, Marano, A, Marano, L, Marchesi, F, Marino, F, Massani, M, Menghi, R, Milone, M, Molfino, S, Montuori, M, Moretto, G, Morgagni, P, Morpurgo, E, Abdallah, M, Nespoli, L, Olmi, S, Palaia, R, Pallabazer, G, Parise, P, Pasculli, A, Pericoli Ridolfini, M, Pesce, A, Pinotti, E, Pisano, M, Poiasina, E, Postiglione, V, Rausei, S, Rella, A, Rosa, F, Rosati, R, Rossi, G, Rossit, L, Rovatti, M, Ruspi, L, Sacco, L, Saladino, E, Sansonetti, A, Sartori, A, Scaglione, D, Scaringi, S, Schoenthaler, C, Sena, G, Simone, M, Solaini, L, Strignano, P, Tartaglia, N, Testa, S, Testini, M, Tiberio, G, Treppiedi, E, Vagliasindi, A, Valmasoni, M, Vigano, J, Zanchettin, G, Zanoni, A, Zardini, C, Zerbinati, A, Mengardo V., Weindelmayer J., Veltri A., Giacopuzzi S., Torroni L., de Manzoni G., Agresta F., Alfieri R., Alfieri S., Antonacci N., Baiocchi G. L., Bencini L., Bencivenga M., Benedetti M., Berselli M., Biondi A., Capolupo G. T., Carboni F., Casadei R., Casella F., Catarci M., Cerri P., Chiari D., Cocozza E., Colombo G., Cozzaglio L., Dalmonte G., Degiuli M., De Luca M., De Luca R., De Manzini N., De Pasqual C. A., De Pascale S., De Ruvo N., Di Cosmo M., Di Leo A., Di Paola M., Elio A., Ferrara F., Ferrari G., Fiscon V., Fumagalli U., Garulli G., Gennai A., Gentile I., Germani P., Gualtierotti M., Guerini F., Gurrado A., Inama M., La Torre F., Laterza E., Losurdo P., Macri A., Marano A., Marano L., Marchesi F., Marino F., Massani M., Menghi R., Milone M., Molfino S., Montuori M., Moretto G., Morgagni P., Morpurgo E., Abdallah M., Nespoli L., Olmi S., Palaia R., Pallabazer G., Parise P., Pasculli A., Pericoli Ridolfini M., Pesce A., Pinotti E., Pisano M., Poiasina E., Postiglione V., Rausei S., Rella A., Rosa F., Rosati R., Rossi G., Rossit L., Rovatti M., Ruspi L., Sacco L., Saladino E., Sansonetti A., Sartori A., Scaglione D., Scaringi S., Schoenthaler C., Sena G., Simone M., Solaini L., Strignano P., Tartaglia N., Testa S., Testini M., Tiberio G. A. M., Treppiedi E., Vagliasindi A., Valmasoni M., Vigano J., Zanchettin G., Zanoni A., Zardini C., and Zerbinati A.
- Abstract
Evidence against the use of prophylactic drain after gastrectomy are increasing and ERAS guidelines suggest the benefit of drain avoidance. Nevertheless, it is unclear whether this practice is still widespread. We conducted a survey among Italian surgeons through the Italian Gastric Cancer Research Group and the Polispecialistic Society of Young Surgeons, aiming to understand the current use of prophylactic drain. A 28-item questionnaire-based survey was developed to analyze the current practice and the individual opinion about the use of prophylactic drain after gastrectomy. Groups based on age, experience and unit volume were separately analyzed. Response of 104 surgeons from 73 surgical units were collected. A standardized ERAS protocol for gastrectomy was applied by 42% of the respondents. Most of the surgeons, regardless of age, experience, or unit volume, declared to routinely place one or more drain after gastrectomy. Only 2 (1.9%) and 7 surgeons (6.7%) belonging to high volume units, do not routinely place drains after total and subtotal gastrectomy, respectively. More than 60% of the participants remove the drain on postoperative day 4–6 after performing an assessment of the anastomosis integrity. Interestingly, less than half of the surgeons believe that drain is the main tool for leak management, and this percentage further drops among younger surgeons. On the other hand, drain’s role seems to be more defined for duodenal stump leak treatment, with almost 50% of the surgeons recognizing its importance. Routine use of prophylactic drain after gastrectomy is still a widespread practice even if younger surgeons are more persuaded that it could not be advantageous.
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- 2022
46. Role of ductular reaction and ductular–canalicular junctions in identifying severe primary biliary cholangitis
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Overi, D, Carpino, G, Cristoferi, L, Onori, P, Kennedy, L, Francis, H, Zucchini, N, Rigamonti, C, Vigano, M, Floreani, A, D'Amato, D, Gerussi, A, Venere, R, Alpini, G, Glaser, S, Alvaro, D, Invernizzi, P, Gaudio, E, Cardinale, V, Carbone, M, Overi D., Carpino G., Cristoferi L., Onori P., Kennedy L., Francis H., Zucchini N., Rigamonti C., Vigano M., Floreani A., D'Amato D., Gerussi A., Venere R., Alpini G., Glaser S., Alvaro D., Invernizzi P., Gaudio E., Cardinale V., Carbone M., Overi, D, Carpino, G, Cristoferi, L, Onori, P, Kennedy, L, Francis, H, Zucchini, N, Rigamonti, C, Vigano, M, Floreani, A, D'Amato, D, Gerussi, A, Venere, R, Alpini, G, Glaser, S, Alvaro, D, Invernizzi, P, Gaudio, E, Cardinale, V, Carbone, M, Overi D., Carpino G., Cristoferi L., Onori P., Kennedy L., Francis H., Zucchini N., Rigamonti C., Vigano M., Floreani A., D'Amato D., Gerussi A., Venere R., Alpini G., Glaser S., Alvaro D., Invernizzi P., Gaudio E., Cardinale V., and Carbone M.
- Abstract
Background & Aims: Primary biliary cholangitis (PBC) is a chronic cholangiopathy characterised by immuno-mediated injury of interlobular bile ducts leading to intrahepatic cholestasis and progressive liver fibrosis. PBC histology is characterised by portal inflammation, progressive fibrosis, ductopenia, and the appearance of the so-called ductular reaction. The aim of the present study was to investigate the pathogenetic relevance of ductular reaction in PBC. Methods: Liver biopsies were collected from naïve people with PBC (N = 87). Clinical–serological parameters were obtained at diagnosis and after 1 year of ursodeoxycholic acid (UDCA) treatment. Histological staging was performed on all slides according to multiple scoring systems and criteria for PBC. Liver samples were obtained from Mdr2−/− mice treated with or without UDCA. Samples were processed for histology, immunohistochemistry, and immunofluorescence. Results: Ductular reaction in people with PBC correlated with the disease stage and liver fibrosis, but not with disease activity; an extensive ductular reaction correlated with serum alkaline phosphatase levels at diagnosis, response to UDCA, and individuals’ estimated survival, independently from other histological parameters, including disease stage. In people with PBC, reactive ductules were associated with the establishment of junctions with bile canaliculi and with fibrogenetic cell activation. Consistently, in a mouse model of intrahepatic cholestasis, UDCA treatment was effective in reducing ductular reaction and fibrosis and increasing ductular–canalicular junctions. Conclusions: Extensive ductular reaction outlines a severe histologic phenotype in PBC and is associated with an inadequate therapy response and a worse estimated prognosis. Lay summary: In people affected by primary biliary cholangitis (PBC), the histological appearance of extensive ductular reaction identifies individuals at risk of progressive fibrosis. Ductular reaction at dia
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- 2022
47. Dysmetabolism, Diabetes and Clinical Outcomes in Patients Cured of Chronic Hepatitis C: A Real-Life Cohort Study
- Author
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Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., Fagiuoli S., Valenti, L, Pelusi, S, Aghemo, A, Gritti, S, Pasulo, L, Bianco, C, Iegri, C, Cologni, G, Degasperi, E, D'Ambrosio, R, del Poggio, P, Soria, A, Puoti, M, Carderi, I, Pigozzi, M, Carriero, C, Spinetti, A, Zuccaro, V, Memoli, M, Giorgini, A, Vigano, M, Rumi, M, Re, T, Spinelli, O, Colombo, M, Quirino, T, Menzaghi, B, Lorini, G, Pan, A, D'Arminio Monforte, A, Buscarini, E, Autolitano, A, Bonfanti, P, Terreni, N, Aimo, G, Mendeni, M, Prati, D, Lampertico, P, Fagiuoli, S, Valenti L., Pelusi S., Aghemo A., Gritti S., Pasulo L., Bianco C., Iegri C., Cologni G., Degasperi E., D'Ambrosio R., del Poggio P., Soria A., Puoti M., Carderi I., Pigozzi M. G., Carriero C., Spinetti A., Zuccaro V., Memoli M., Giorgini A., Vigano M., Rumi M. G., Re T., Spinelli O., Colombo M. C., Quirino T., Menzaghi B., Lorini G., Pan A., D'Arminio Monforte A., Buscarini E., Autolitano A., Bonfanti P., Terreni N., Aimo G., Mendeni M., Prati D., Lampertico P., Colombo M., and Fagiuoli S.
- Abstract
The aim of this study was to examine the impact of features of dysmetabolism on liver disease severity, evolution, and clinical outcomes in a real-life cohort of patients treated with direct acting antivirals for chronic hepatitis C virus (HCV) infection. To this end, we considered 7,007 patients treated between 2014 and 2018, 65.3% with advanced fibrosis, of whom 97.7% achieved viral eradication (NAVIGATORE-Lombardia registry). In a subset (n = 748), liver stiffness measurement (LSM) was available at baseline and follow-up. Higher body mass index (BMI; odds ratio [OR] 1.06 per kg/m2, 1.03-1.09) and diabetes (OR 2.01 [1.65-2.46]) were independently associated with advanced fibrosis at baseline, whereas statin use was protective (OR 0.46 [0.35-0.60]; P < 0.0001 for all). The impact of BMI was greater in those without diabetes (P = 0.003). Diabetes was independently associated with less pronounced LSM improvement after viral eradication (P = 0.001) and in patients with advanced fibrosis was an independent predictor of the most frequent clinical events, namely de novo hepatocellular carcinoma (HCC; hazard ratio [HR] 2.09 [1.20-3.63]; P = 0.009) and cardiovascular events (HR 2.73 [1.16-6.43]; P = 0.021). Metformin showed a protective association against HCC (HR 0.32 [0.11-0.96]; P = 0.043), which was confirmed after adjustment for propensity score (P = 0.038). Diabetes diagnosis further refined HCC prediction in patients with compensated advanced chronic liver disease at high baseline risk (P = 0.024). Conclusion: Metabolic comorbidities were associated with advanced liver fibrosis at baseline, whereas statins were protective. In patients with advanced fibrosis, diabetes increased the risk of de novo HCC and of cardiovascular events. Optimization of metabolic comorbidities treatment by a multi-disciplinary management approach may improve cardiovascular and possibly liver-related
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- 2022
48. The Italian Aphasia Awareness Survey (IAAS): an online questionnaire about the public knowledge of aphasia in Italy, informative findings
- Author
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Vigano, M, Gilardone, G, Cassinelli, D, Fumagalli, F, Scialla, M, Gilardone, M, Dameno, R, Corbo, M, Monti, A, Vigano M., Gilardone G., Cassinelli D., Fumagalli F. M., Scialla M., Gilardone M., Dameno R., Corbo M., Monti A., Vigano, M, Gilardone, G, Cassinelli, D, Fumagalli, F, Scialla, M, Gilardone, M, Dameno, R, Corbo, M, Monti, A, Vigano M., Gilardone G., Cassinelli D., Fumagalli F. M., Scialla M., Gilardone M., Dameno R., Corbo M., and Monti A.
- Abstract
Background: According to surveys conducted in several countries, public awareness and knowledge of aphasia are inadequately low. Persons with aphasia appoint this fact as a relevant environmental barrier. Aims: The present inquiry aims at analyzing the status of awareness and knowledge about aphasia in Italy. Methods & Procedures: An original questionnaire was distributed online through a snowball sampling method on the Italian adult population. Respondents were asked if they had heard of the term “aphasia” and subsequently tested on its definition and clinical characteristics. Similar questions regarding “celiac disease” and “Down syndrome” were asked for comparison. Demographic data and information about the source of knowledge were also recorded. Outcomes & Results: Considering 2172 respondents, 62.4% had heard of aphasia, 58.2% showed definition knowledge while 4.6% complete general knowledge. These rates were lower than those for the other medical conditions. Older age, female gender, higher education, and being a health professional were significantly associated with awareness. The questionnaire highlighted poor knowledge about the social and functional consequences of aphasia. Conclusions: Overall, the rates of aphasia awareness and knowledge were low. Despite health professionals performed better, the level of general knowledge was also poor among these respondents. These preliminary data set the need for further inquiries, undertaking appropriate methodological ameliorations.
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- 2022
49. A longitudinal analysis of a work inclusion model for psychiatric patients in the Mental Health Departments of the city of Milan
- Author
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Ferrara, L, Varinelli, A, Caricasole, V, Dragoni, C, Mazzardis, S, Quarenghi, A, Rubelli, P, Fusi, A, Percudani, M, Cisima, M, Mencacci, C, Maranesi, T, Gambini, O, Barbieri, V, Brambilla, P, Lazzaretti, M, Carra, G, Latina, A, Vigano, C, Dell'Osso, B, Ferrara L., Varinelli A., Caricasole V., Dragoni C., Mazzardis S., Quarenghi A., Rubelli P., Fusi A., Percudani M., Cisima M., Mencacci C., Maranesi T., Gambini O., Barbieri V., Brambilla P., Lazzaretti M., Carra G., Latina A., Vigano C., Dell'Osso B., Ferrara, L, Varinelli, A, Caricasole, V, Dragoni, C, Mazzardis, S, Quarenghi, A, Rubelli, P, Fusi, A, Percudani, M, Cisima, M, Mencacci, C, Maranesi, T, Gambini, O, Barbieri, V, Brambilla, P, Lazzaretti, M, Carra, G, Latina, A, Vigano, C, Dell'Osso, B, Ferrara L., Varinelli A., Caricasole V., Dragoni C., Mazzardis S., Quarenghi A., Rubelli P., Fusi A., Percudani M., Cisima M., Mencacci C., Maranesi T., Gambini O., Barbieri V., Brambilla P., Lazzaretti M., Carra G., Latina A., Vigano C., and Dell'Osso B.
- Abstract
Background: Work functioning impairment is a key diagnostic and transnosographic criterion for psychiatric disorders in both DSM-5 and ICD-11. Occupational inclusion is a fundamental aspect of the care path for patients attending the territorial services provided by the Italian Mental Health and Addiction Departments (DSMDs). Since 2009, the Regional Innovative Programme (PIR) TR106, promoted by the Fatebenefratelli-Sacco hospital of Milan, Italy, in collaboration with six other metropolitan DSMDs, was created to promote integration for people suffering from mental health problems in the city of Milan. Method: Here we present the results of a retrospective epidemiologic analysis on 2,142 interventions on 1,066 patients, conducted between 2012 and 2019. Results: Most of the interventions were conducted with people with psychotic disorders (39%), followed by personality disorders (25.2%) and affective disorders (22.2%). The age range of 25 to 54 years represented 91.5% of the whole sample, mainly in the 35 to 44 years range (36.4%). Significant age group-related changes in interventions were observed in the observation period, with a reduction in the interventions provided to subjects of the 35 to 44 age group, and an increase in the 25 to 34 age group. Conclusions: PIR TR106 provided the most accurate assessment and data collection so far for the city of Milan. Our data characterised psychiatric groups in order to develop specific treatment plans and work inclusion interventions.
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- 2022
50. Technical feasibility and short-term outcomes of laparoscopic isolated caudate lobe resection: an IgoMILS (Italian Group of Minimally Invasive Liver Surgery) registry-based study
- Author
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Ruzzenente, A, Ciangherotti, A, Aldrighetti, L, Ettorre, G, De Carlis, L, Ferrero, A, Dalla Valle, R, Tisone, G, Guglielmi, A, Ratti, F, Gringeri, E, Russolillo, N, Campagnaro, T, Conci, S, Sandri, G, Ardito, F, Boggi, U, Gruttadauria, S, Vigano, L, Di Benedetto, F, Rossi, G, Berti, S, Ceccarelli, G, Vincenti, L, Cillo, U, Giuliante, F, Mazzaferro, V, Jovine, E, Calise, F, Belli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Ferla, F, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Boni, L, Maida, P, Griseri, G, Filauro, M, Guerriero, S, Romito, R, Tedeschi, U, Zimmitti, G, Ruzzenente A., Ciangherotti A., Aldrighetti L., Ettorre G. M., De Carlis L., Ferrero A., Dalla Valle R., Tisone G., Guglielmi A., Ratti F., Gringeri E., Russolillo N., Campagnaro T., Conci S., Sandri G. B. L., Ardito F., Boggi U., Gruttadauria S., Vigano L., Di Benedetto F., Rossi G. E., Berti S., Ceccarelli G., Vincenti L., Cillo U., Giuliante F., Mazzaferro V., Jovine E., Calise F., Belli G., Zamboni F., Coratti A., Mezzatesta P., Santambrogio R., Navarra G., Giuliani A., Ferla F., Pinna A. D., Parisi A., Colledan M., Slim A., Antonucci A., Grazi G. L., Frena A., Sgroi G., Brolese A., Morelli L., Floridi A., Patriti A., Veneroni L., Boni L., Maida P., Griseri G., Filauro M., Guerriero S., Romito R., Tedeschi U., Zimmitti G., Ruzzenente, A, Ciangherotti, A, Aldrighetti, L, Ettorre, G, De Carlis, L, Ferrero, A, Dalla Valle, R, Tisone, G, Guglielmi, A, Ratti, F, Gringeri, E, Russolillo, N, Campagnaro, T, Conci, S, Sandri, G, Ardito, F, Boggi, U, Gruttadauria, S, Vigano, L, Di Benedetto, F, Rossi, G, Berti, S, Ceccarelli, G, Vincenti, L, Cillo, U, Giuliante, F, Mazzaferro, V, Jovine, E, Calise, F, Belli, G, Zamboni, F, Coratti, A, Mezzatesta, P, Santambrogio, R, Navarra, G, Giuliani, A, Ferla, F, Pinna, A, Parisi, A, Colledan, M, Slim, A, Antonucci, A, Grazi, G, Frena, A, Sgroi, G, Brolese, A, Morelli, L, Floridi, A, Patriti, A, Veneroni, L, Boni, L, Maida, P, Griseri, G, Filauro, M, Guerriero, S, Romito, R, Tedeschi, U, Zimmitti, G, Ruzzenente A., Ciangherotti A., Aldrighetti L., Ettorre G. M., De Carlis L., Ferrero A., Dalla Valle R., Tisone G., Guglielmi A., Ratti F., Gringeri E., Russolillo N., Campagnaro T., Conci S., Sandri G. B. L., Ardito F., Boggi U., Gruttadauria S., Vigano L., Di Benedetto F., Rossi G. E., Berti S., Ceccarelli G., Vincenti L., Cillo U., Giuliante F., Mazzaferro V., Jovine E., Calise F., Belli G., Zamboni F., Coratti A., Mezzatesta P., Santambrogio R., Navarra G., Giuliani A., Ferla F., Pinna A. D., Parisi A., Colledan M., Slim A., Antonucci A., Grazi G. L., Frena A., Sgroi G., Brolese A., Morelli L., Floridi A., Patriti A., Veneroni L., Boni L., Maida P., Griseri G., Filauro M., Guerriero S., Romito R., Tedeschi U., and Zimmitti G.
- Abstract
Background: Although isolated caudate lobe (CL) liver resection is not a contraindication for minimally invasive liver surgery (MILS), feasibility and safety of the procedure are still poorly investigated. To address this gap, we evaluate data on the Italian prospective maintained database on laparoscopic liver surgery (IgoMILS) and compare outcomes between MILS and open group. Methods: Perioperative data of patients with malignancies, as colorectal liver metastases (CRLM), hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), non-colorectal liver metastases (NCRLM) and benign liver disease, were retrospectively analyzed. A propensity score matching (PSM) analysis was performed to balance the potential selection bias for MILS and open group. Results: A total of 224 patients were included in the study, 47 and 177 patients underwent MILS and open isolated CL resection, respectively. The overall complication rate was comparable between the two groups; however, severe complication rate (Dindo–Clavien grade ≥ 3) was lower in the MILS group (0% versus 6.8%, P = ns). In-hospital mortality was 0% in both groups and mean hospital stay was significantly shorter in the MILS group (P = 0.01). After selection of 42 MILS and 43 open CL resections by PSM analysis, intraoperative and postoperative outcomes remained similar except for the hospital stay which was not significantly shorter in MILS group. Conclusions: This multi-institutional cohort study shows that MILS CL resection is feasible and safe. The surgical procedure can be technically demanding compared to open resection, whereas good perioperative outcomes can be achieved in highly selected patients.
- Published
- 2022
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