Search

Your search keyword '"Van Geloven, N."' showing total 55 results
Start Over Author "Van Geloven, N." Publication Type Electronic Resources
55 results on '"Van Geloven, N."'

1. External validation of a frequently used prediction model for ongoing pregnancy in couples with unexplained recurrent pregnancy loss

Author

Geboortecentrum voorzitterschap, Child Health, Youssef, A., van der Hoorn, M. L.P., Dongen, M., Visser, J., Bloemenkamp, K., van Lith, J., van Geloven, N., Lashley, E. E.L.O., Geboortecentrum voorzitterschap, Child Health, Youssef, A., van der Hoorn, M. L.P., Dongen, M., Visser, J., Bloemenkamp, K., van Lith, J., van Geloven, N., and Lashley, E. E.L.O.

Published
2022

4. Does the effectiveness of IUI in couples with unexplained subfertility depend on their prognosis of natural conception?: A replication of the H2Oil study

Author

Biostatistiek Onderzoek, Child Health, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, Rosielle, K, van Welie, N, Dreyer, K, van Wely, M, Mol, B W, Eijkemans, M J, Mijatovic, V, van Geloven, N, Biostatistiek Onderzoek, Child Health, Circulatory Health, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, Rosielle, K, van Welie, N, Dreyer, K, van Wely, M, Mol, B W, Eijkemans, M J, Mijatovic, V, and van Geloven, N

Published
2020

5. The therapeutic effect of hysterosalpingography in couples with unexplained subfertility : a post-hoc analysis of a prospective multi-centre cohort study

Author

Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., van Geloven, N., Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., and van Geloven, N.

Published
2019

6. Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

Author

van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, Eijkemans, M J, van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, and Eijkemans, M J

Published
2019

7. Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility

Author

McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., Bhattacharya, S., McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., and Bhattacharya, S.

Published
2019

8. IVF for unexplained subfertility; Whom should we treat?

Author

Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., McLernon, D. J., Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., and McLernon, D. J.

Published
2019

9. The therapeutic effect of hysterosalpingography in couples with unexplained subfertility : a post-hoc analysis of a prospective multi-centre cohort study

Author

Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., van Geloven, N., Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., and van Geloven, N.

Published
2019

10. Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility

Author

McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., Bhattacharya, S., McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., and Bhattacharya, S.

Published
2019

11. IVF for unexplained subfertility; Whom should we treat?

Author

Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., McLernon, D. J., Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., and McLernon, D. J.

Published
2019

12. Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

Author

van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, Eijkemans, M J, van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, and Eijkemans, M J

Published
2019

13. Immediate versus delayed removal of urinary catheter after laparoscopic hysterectomy: A randomised controlled trial

Author

Sandberg, E. M. (author), Twijnstra, A.R.H. (author), van Meir, C. A. (author), Kok, H. S. (author), van Geloven, N. (author), Gludovacz, K. (author), Kolkman, W. (author), Nagel, H.T.C. (author), Haans, L.C.F. (author), Kapiteijn, K. (author), Jansen, F.W. (author), Sandberg, E. M. (author), Twijnstra, A.R.H. (author), van Meir, C. A. (author), Kok, H. S. (author), van Geloven, N. (author), Gludovacz, K. (author), Kolkman, W. (author), Nagel, H.T.C. (author), Haans, L.C.F. (author), Kapiteijn, K. (author), and Jansen, F.W. (author)

Abstract

Objective: To evaluate if immediate catheter removal (ICR) after laparoscopic hysterectomy is associated with similar retention outcomes compared with delayed removal (DCR). Study design: Non-inferiority randomised controlled trial. Population: Women undergoing laparoscopic hysterectomy in six hospitals in the Netherlands. Methods: Women were randomised to ICR or DCR (between 18 and 24 hours after surgery). Primary outcome: The inability to void within 6 hours after catheter removal. Results: One hundred and fifty-five women were randomised to ICR (n = 74) and DCR (n = 81). The intention-to-treat and per-protocol analysis could not demonstrate the non-inferiority of ICR: ten women with ICR could not urinate spontaneously within 6 hours compared with none in the delayed group (risk difference 13.5%, 5.6–24.8, P = 0.88). However, seven of these women could void spontaneously within 9 hours without additional intervention. Regarding the secondary outcomes, eight women from the delayed group requested earlier catheter removal because of complaints (9.9%). Three women with ICR (4.1%) had a urinary tract infection postoperatively versus eight with DCR (9.9%, risk difference −5.8%, −15.1 to 3.5, P = 0.215). Women with ICR mobilised significantly earlier (5.7 hours, 0.8–23.3 versus 21.0 hours, 1.4–29.9; P ≤ 0.001). Conclusion: The non-inferiority of ICR could not be demonstrated in terms of urinary retention 6 hours after procedure. However, 70% of the women with voiding difficulties could void spontaneously within 9 hours after laparoscopic hysterectomy. It is therefore questionable if all observed urinary retention cases were clinically relevant. As a result, the clinical advantages of ICR may still outweigh the risk of bladder retention and it should therefore be considered after uncomplicated laparoscopic hysterectomy. Tweetable abstract: The advantages of immediate catheter removal after laparoscopic hysterectomy seem to outweigh the risk of bladder retention., Medical Instruments & Bio-Inspired Technology

Published
2019
Full Text
View/download PDF

14. Efficacy and safety of IVIG in CIDP: Combined data of the PRIMA and PATH studies

Author

Merkies, ISJ, van Schaik, IN, Leger, J-M, Bril, V, van Geloven, N, Hartung, H-P, Lewis, RA, Sobue, G, Lawo, J-P, Durn, BL, Cornblath, DR, De Bleecker, JL, Sommer, C, Robberecht, W, Saarela, M, Kamienowski, J, Stelmasiak, Z, Tackenberg, B, Mielke, O, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, D'Amour, C, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, A, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentzsch, J, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, R, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, A, Bethke, F, Drory, V, Algom, A, Yarnitsky, D, Murinson, B, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, Eftimov, F, Notermans, NC, Visser, N, Faber, C, Hoeijmakers, J, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Antonia, M, Gamez, J, Salvado, M, Marquez Infante, C, Benitez, S, Lunn, M, Morrow, J, Gosal, D, Lavin, T, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, Lai, EC-H, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, T, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, Gable, K, Franques, J, Morales, RJ, Nguento, A, Schrey, C, Zwolinska, G, Merkies, ISJ, van Schaik, IN, Leger, J-M, Bril, V, van Geloven, N, Hartung, H-P, Lewis, RA, Sobue, G, Lawo, J-P, Durn, BL, Cornblath, DR, De Bleecker, JL, Sommer, C, Robberecht, W, Saarela, M, Kamienowski, J, Stelmasiak, Z, Tackenberg, B, Mielke, O, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, D'Amour, C, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, A, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentzsch, J, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, R, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, A, Bethke, F, Drory, V, Algom, A, Yarnitsky, D, Murinson, B, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, Eftimov, F, Notermans, NC, Visser, N, Faber, C, Hoeijmakers, J, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Antonia, M, Gamez, J, Salvado, M, Marquez Infante, C, Benitez, S, Lunn, M, Morrow, J, Gosal, D, Lavin, T, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, Lai, EC-H, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, T, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, Gable, K, Franques, J, Morales, RJ, Nguento, A, Schrey, C, and Zwolinska, G

Abstract

Intravenous immunoglobulin (IVIG) is a potential therapy for chronic inflammatory demyelinating polyneuropathy (CIDP). To investigate the efficacy and safety of the IVIG IgPro10 (Privigen) for treatment of CIDP, results from Privigen Impact on Mobility and Autonomy (PRIMA), a prospective, open-label, single-arm study of IVIG in immunoglobulin (Ig)-naïve or IVIG pre-treated subjects (NCT01184846, n = 28) and Polyneuropathy And Treatment with Hizentra (PATH), a double-blind, randomized study including an open-label, single-arm IVIG phase in IVIG pre-treated subjects (NCT01545076, IVIG restabilization phase n = 207) were analyzed separately and together (n = 235). Efficacy assessments included change in adjusted inflammatory neuropathy cause and treatment (INCAT) score, grip strength and Medical Research Council (MRC) sum score. Adverse drug reactions (ADRs) and ADRs/infusion were recorded. Adjusted INCAT response rate was 60.7% in all PRIMA subjects at Week 25 (76.9% in IVIG pre-treated subjects) and 72.9% in PATH. In the pooled cohort (n = 235), INCAT response rate was 71.5%; median time to INCAT improvement was 4.3 weeks. No clear demographic differences were noticed between early (responding before Week 7, n = 148) and late responders (n = 21). In the pooled cohort, median change from baseline to last observation was -1.0 (interquartile range -2.0; 0.0) point for INCAT score; +8.0 (0.0; 20.0) kPa for maximum grip strength; +3.0 (1.0; 7.0) points for MRC sum score. In the pooled cohort, 271 ADRs were reported in 105 subjects (44.7%), a rate of 0.144 ADRs per infusion. This analysis confirms the efficacy and safety of IgPro10, a recently FDA-approved IVIG for CIDP, in a population of mainly pre-treated subjects with CIDP [Correction added on 14 March 2019 after first online publication: the INCAT response rate has been corrected.].

Published
2019

15. Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy: Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study

Author

Mielke, O, Bril, V, Cornblath, DR, Lawo, J-P, van Geloven, N, Hartung, H-P, Lewis, RA, Merkies, ISJ, Sobue, G, Durn, B, Shebl, A, van Schaik, IN, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, D'Amour, C, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Saarela, M, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, A, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentzsch, J, Sommer, C, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, R, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, A, Bethke, F, Drory, V, Algom, A, Yarnitsky, D, Murinson, B, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, Eftimov, F, Notermans, NC, Visser, N, Faber, C, Hoeijmakers, J, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Antonia, M, Gamez, J, Salvado, M, Marquez Infante, C, Benitez, S, Lunn, M, Morrow, J, Gosal, D, Lavin, T, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, E, Lai, EC-H, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, T, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, Gable, K, Mielke, O, Bril, V, Cornblath, DR, Lawo, J-P, van Geloven, N, Hartung, H-P, Lewis, RA, Merkies, ISJ, Sobue, G, Durn, B, Shebl, A, van Schaik, IN, Sabet, A, George, K, Roberts, L, Carne, R, Blum, S, Henderson, R, Van Damme, P, Demeestere, J, Larue, S, D'Amour, C, Kunc, P, Valis, M, Sussova, J, Kalous, T, Talab, R, Bednar, M, Toomsoo, T, Rubanovits, I, Gross-Paju, K, Sorro, U, Saarela, M, Auranen, M, Pouget, J, Attarian, S, Le Masson, G, Wielanek-Bachelet, A, Desnuelle, C, Delmont, E, Clavelou, P, Aufauvre, D, Schmidt, J, Zschuentzsch, J, Sommer, C, Kramer, D, Hoffmann, O, Goerlitz, C, Haas, J, Chatzopoulos, M, Yoon, R, Gold, R, Berlit, P, Jaspert-Grehl, A, Liebetanz, D, Kutschenko, A, Stangel, M, Trebst, C, Baum, P, Bergh, F, Klehmet, J, Meisel, A, Klostermann, F, Oechtering, J, Lehmann, H, Schroeter, M, Hagenacker, T, Mueller, D, Sperfeld, A, Bethke, F, Drory, V, Algom, A, Yarnitsky, D, Murinson, B, Di Muzio, A, Ciccocioppo, F, Sorbi, S, Mata, S, Schenone, A, Grandis, M, Lauria, G, Cazzato, D, Antonini, G, Morino, S, Cocito, D, Zibetti, M, Yokota, T, Ohkubo, T, Kanda, T, Kawai, M, Kaida, K, Onoue, H, Kuwabara, S, Mori, M, Iijima, M, Ohyama, K, Baba, M, Tomiyama, M, Nishiyama, K, Akutsu, T, Yokoyama, K, Kanai, K, Eftimov, F, Notermans, NC, Visser, N, Faber, C, Hoeijmakers, J, Rejdak, K, Chyrchel-Paszkiewicz, U, Casanovas Pons, C, Antonia, M, Gamez, J, Salvado, M, Marquez Infante, C, Benitez, S, Lunn, M, Morrow, J, Gosal, D, Lavin, T, Melamed, I, Testori, A, Ajroud-Driss, S, Menichella, D, Simpson, E, Lai, EC-H, Dimachkie, M, Barohn, RJ, Beydoun, S, Johl, H, Lange, D, Shtilbans, A, Muley, S, Ladha, S, Freimer, M, Kissel, J, Latov, N, Chin, R, Ubogu, E, Mumfrey, S, Rao, T, MacDonald, P, Sharma, K, Gonzalez, G, Allen, J, Walk, D, Hobson-Webb, L, and Gable, K

Abstract

In patients with chronic inflammatory demyelinating polyneuropathy (CIDP), intravenous immunoglobulin (IVIG) is recommended to be periodically reduced to assess the need for ongoing therapy. However, little is known about the effectiveness of restabilization with IVIG in patients who worsen after IVIG withdrawal. In the Polyneuropathy And Treatment with Hizentra (PATH) study, the pre-randomization period included sudden stopping of IVIG followed by 12 weeks of observation. Those deteriorating were then restabilized with IVIG. Of 245 subjects who stopped IVIG, 28 did not show signs of clinical deterioration within 12 weeks. Two hundred and seven received IVIG restabilization with an induction dose of 2 g/kg bodyweight (bw) IgPro10 (Privigen, CSL Behring, King of Prussia, Pennsylvania) and maintenance doses of 1 g/kg bw every 3 weeks for up to 13 weeks. Signs of clinical improvement were seen in almost all (n = 188; 91%) subjects. During IVIG restabilization, 35 subjects either did not show CIDP stability (n = 21, analyzed as n = 22 as an additional subject was randomized in error) or withdrew for other reasons (n = 14). Of the 22 subjects who did not achieve clinical stability, follow-up information in 16 subjects after an additional 4 weeks was obtained. Nine subjects were reported to have improved, leaving a maximum of 27 subjects (13%) who either showed no signs of clinical improvement during the restabilization phase and 4 weeks post-study or withdrew for other reasons. In conclusion, sudden IVIG withdrawal was effective in detecting ongoing immunoglobulin G dependency with a small risk for subjects not returning to their baseline 17 weeks after withdrawal.

Published
2019

16. IVF for unexplained subfertility; Whom should we treat?

Author

Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., McLernon, D. J., Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., and McLernon, D. J.

Published
2019

17. Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility

Author

McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., Bhattacharya, S., McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., and Bhattacharya, S.

Published
2019

18. Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

Author

van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, Eijkemans, M J, van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, and Eijkemans, M J

Published
2019

19. The therapeutic effect of hysterosalpingography in couples with unexplained subfertility : a post-hoc analysis of a prospective multi-centre cohort study

Author

Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., van Geloven, N., Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., and van Geloven, N.

Published
2019

20. The therapeutic effect of hysterosalpingography in couples with unexplained subfertility: a post-hoc analysis of a prospective multi-centre cohort study

Author

Biostatistiek Onderwijs, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., van Geloven, N., Biostatistiek Onderwijs, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Dreyer, K., van Eekelen, R., Tjon-Kon-Fat, R. I., van der Steeg, J. W., Steures, P., Eijkemans, M. J.C., van der Veen, F., Hompes, P. G.A., Mol, B. W.J., and van Geloven, N.

Published
2019

21. Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility

Author

Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., Bhattacharya, S., Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, McLernon, D. J., Lee, A. J., Maheshwari, A., Van Eekelen, R., Van Geloven, N., Putter, H., Eijkemans, M. J., Van Der Steeg, J. W., Van Der Veen, F., Steyerberg, E. W., Mol, B. W., and Bhattacharya, S.

Published
2019

22. IVF for unexplained subfertility; Whom should we treat?

Author

Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., McLernon, D. J., Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Van Eekelen, R., Van Geloven, N., Van Wely, M., Bhattacharya, S., Van Der Veen, F., Eijkemans, M. J., and McLernon, D. J.

Published
2019

23. Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

Author

Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, Eijkemans, M J, Biostatistiek Onderwijs, JC onderzoeksprogramma Methodologie, MS VPG/Gynaecologie, Biostatistiek Onderzoek, Infection & Immunity, van Eekelen, R, van Geloven, N, van Wely, M, McLernon, D J, Mol, F, Custers, I M, Steures, P, Bhattacharya, S, Mol, B W, van der Veen, F, and Eijkemans, M J

Published
2019

24. Immediate versus delayed removal of urinary catheter after laparoscopic hysterectomy: A randomised controlled trial

Author

Sandberg, E. M. (author), Twijnstra, A.R.H. (author), van Meir, C. A. (author), Kok, H. S. (author), van Geloven, N. (author), Gludovacz, K. (author), Kolkman, W. (author), Nagel, H.T.C. (author), Haans, L.C.F. (author), Kapiteijn, K. (author), Jansen, F.W. (author), Sandberg, E. M. (author), Twijnstra, A.R.H. (author), van Meir, C. A. (author), Kok, H. S. (author), van Geloven, N. (author), Gludovacz, K. (author), Kolkman, W. (author), Nagel, H.T.C. (author), Haans, L.C.F. (author), Kapiteijn, K. (author), and Jansen, F.W. (author)

Abstract

Objective: To evaluate if immediate catheter removal (ICR) after laparoscopic hysterectomy is associated with similar retention outcomes compared with delayed removal (DCR). Study design: Non-inferiority randomised controlled trial. Population: Women undergoing laparoscopic hysterectomy in six hospitals in the Netherlands. Methods: Women were randomised to ICR or DCR (between 18 and 24 hours after surgery). Primary outcome: The inability to void within 6 hours after catheter removal. Results: One hundred and fifty-five women were randomised to ICR (n = 74) and DCR (n = 81). The intention-to-treat and per-protocol analysis could not demonstrate the non-inferiority of ICR: ten women with ICR could not urinate spontaneously within 6 hours compared with none in the delayed group (risk difference 13.5%, 5.6–24.8, P = 0.88). However, seven of these women could void spontaneously within 9 hours without additional intervention. Regarding the secondary outcomes, eight women from the delayed group requested earlier catheter removal because of complaints (9.9%). Three women with ICR (4.1%) had a urinary tract infection postoperatively versus eight with DCR (9.9%, risk difference −5.8%, −15.1 to 3.5, P = 0.215). Women with ICR mobilised significantly earlier (5.7 hours, 0.8–23.3 versus 21.0 hours, 1.4–29.9; P ≤ 0.001). Conclusion: The non-inferiority of ICR could not be demonstrated in terms of urinary retention 6 hours after procedure. However, 70% of the women with voiding difficulties could void spontaneously within 9 hours after laparoscopic hysterectomy. It is therefore questionable if all observed urinary retention cases were clinically relevant. As a result, the clinical advantages of ICR may still outweigh the risk of bladder retention and it should therefore be considered after uncomplicated laparoscopic hysterectomy. Tweetable abstract: The advantages of immediate catheter removal after laparoscopic hysterectomy seem to outweigh the risk of bladder retention., Medical Instruments & Bio-Inspired Technology

Published
2019
Full Text
View/download PDF

26. Natural conception rates in couples with unexplained or mild male subfertility scheduled for fertility treatment : A secondary analysis of a randomized controlled trial

Author

Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., Van Wely, M., Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., and Van Wely, M.

Published
2018

27. Natural conception rates in couples with unexplained or mild male subfertility scheduled for fertility treatment : A secondary analysis of a randomized controlled trial

Author

Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., Van Wely, M., Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., and Van Wely, M.

Published
2018

29. Surgical outcomes of laparoscopic hysterectomy with concomitant endometriosis without bowel or bladder dissection: A cohort analysis to define a case-mix variable

Author

Sandberg, E.M. (author), Driessen, S.R.C. (author), Bak, E.A.T. (author), van Geloven, N. (author), Berger, J.P. (author), Smeets, M.J.G.H. (author), Rhemrev, J.P.T. (author), Jansen, F.W. (author), Sandberg, E.M. (author), Driessen, S.R.C. (author), Bak, E.A.T. (author), van Geloven, N. (author), Berger, J.P. (author), Smeets, M.J.G.H. (author), Rhemrev, J.P.T. (author), and Jansen, F.W. (author)

Abstract

Background: Pelvic endometriosis is often mentioned as one of the variables influencing surgical outcomes of laparoscopic hysterectomy (LH). However, its additional surgical risks have not been well established. The aim of this study was to analyze to what extent concomitant endometriosis influences surgical outcomes of LH and to determine if it should be considered as case-mix variable. Results: A total of 2655 LH’s were analyzed, of which 397 (15.0%) with concomitant endometriosis. For blood loss and operative time, no measurable association was found for stages I (n = 106) and II (n = 103) endometriosis compared to LH without endometriosis. LH with stages III (n = 93) and IV (n = 95) endometriosis were associated with more intra-operative blood loss (p = <.001) and a prolonged operative time (p = <.001) compared to LH without endometriosis. No significant association was found between endometriosis (all stages) and complications (p =.62). Conclusions: The findings of our study have provided numeric support for the influence of concomitant endometriosis on surgical outcomes of LH, without bowel or bladder dissection. Only stages III and IV were associated with a longer operative time and more blood loss and should thus be considered as case-mix variables in future quality measurement tools., Medical Instruments & Bio-Inspired Technology

Published
2018
Full Text
View/download PDF

31. Natural conception rates in couples with unexplained or mild male subfertility scheduled for fertility treatment : A secondary analysis of a randomized controlled trial

Author

Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., Van Wely, M., Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., and Van Wely, M.

Published
2018

32. External validation of a dynamic prediction model for repeated predictions of natural conception over time

Author

Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, McLernon, D J, van Wely, M, Eijkemans, M J, Bhattacharya, S, van der Veen, F, van Geloven, N, Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, McLernon, D J, van Wely, M, Eijkemans, M J, Bhattacharya, S, van der Veen, F, and van Geloven, N

Published
2018

33. Natural conception rates in couples with unexplained or mild male subfertility scheduled for fertility treatment: A secondary analysis of a randomized controlled trial

Author

Data Science & Biostatistiek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., Van Wely, M., Data Science & Biostatistiek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, Van Eekelen, R., Tjon-Kon-Fat, R. I., Bossuyt, P. M.M., Van Geloven, N., Eijkemans, M. J.C., Bensdorp, A. J., Van Der Veen, F., Mol, B. W., and Van Wely, M.

Published
2018

34. Surgical outcomes of laparoscopic hysterectomy with concomitant endometriosis without bowel or bladder dissection: A cohort analysis to define a case-mix variable

Author

Sandberg, E.M. (author), Driessen, S.R.C. (author), Bak, E.A.T. (author), van Geloven, N. (author), Berger, J.P. (author), Smeets, M.J.G.H. (author), Rhemrev, J.P.T. (author), Jansen, F.W. (author), Sandberg, E.M. (author), Driessen, S.R.C. (author), Bak, E.A.T. (author), van Geloven, N. (author), Berger, J.P. (author), Smeets, M.J.G.H. (author), Rhemrev, J.P.T. (author), and Jansen, F.W. (author)

Abstract

Background: Pelvic endometriosis is often mentioned as one of the variables influencing surgical outcomes of laparoscopic hysterectomy (LH). However, its additional surgical risks have not been well established. The aim of this study was to analyze to what extent concomitant endometriosis influences surgical outcomes of LH and to determine if it should be considered as case-mix variable. Results: A total of 2655 LH’s were analyzed, of which 397 (15.0%) with concomitant endometriosis. For blood loss and operative time, no measurable association was found for stages I (n = 106) and II (n = 103) endometriosis compared to LH without endometriosis. LH with stages III (n = 93) and IV (n = 95) endometriosis were associated with more intra-operative blood loss (p = <.001) and a prolonged operative time (p = <.001) compared to LH without endometriosis. No significant association was found between endometriosis (all stages) and complications (p =.62). Conclusions: The findings of our study have provided numeric support for the influence of concomitant endometriosis on surgical outcomes of LH, without bowel or bladder dissection. Only stages III and IV were associated with a longer operative time and more blood loss and should thus be considered as case-mix variables in future quality measurement tools., Medical Instruments & Bio-Inspired Technology

Published
2018
Full Text
View/download PDF

36. Natural conception : Repeated predictions overtime

Author

Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, van Geloven, N., Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, and van Geloven, N.

Published
2017

38. Natural conception : Repeated predictions overtime

Author

Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, van Geloven, N., Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, and van Geloven, N.

Published
2017

40. Natural conception : Repeated predictions overtime

Author

Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, van Geloven, N., Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, and van Geloven, N.

Published
2017

41. Constructing the crystal ball: how to get reliable prognostic information for the management of subfertile couples

Author

Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, van Geloven, N., Wely, M., McLernon, D J, Eijkemans, M J, Repping, S., Steyerberg, Ewout W., Mol, Ben W., Bhattacharya, S., van der Veen, F, Biostatistiek Onderwijs, Biostatistiek Onderzoek, Infection & Immunity, Circulatory Health, Child Health, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, van Eekelen, R, van Geloven, N., Wely, M., McLernon, D J, Eijkemans, M J, Repping, S., Steyerberg, Ewout W., Mol, Ben W., Bhattacharya, S., and van der Veen, F

Published
2017

42. Natural conception: Repeated predictions overtime

Author

Biostatistiek Onderwijs, UMC Utrecht, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, van Geloven, N., Biostatistiek Onderwijs, UMC Utrecht, Circulatory Health, Child Health, JC onderzoeksprogramma Methodologie, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Van Eekelen, R., Scholten, I, Tjon-Kon-Fat, R.I., van der Steeg, J.W., Steures, P., Hompes, Peter, Wely, M., van der Veen, F, Mol, B. W J, Eijkemans, M. J., te Velde, Egbert R, and van Geloven, N.

Published
2017

43. Update on the Preventive Antibiotics in Stroke Study (PASS): a randomised controlled phase 3 clinical trial

Author

Westendorp, WF, Vermeij, JD, van Geloven, N, Dippel, Diederik, Dijkgraaf, MGW, van der Poll, T, Prins, JM, Spanjaard, L, Vermeij, Frederique, Nederkoorn, PJ, de Beek, DV, Westendorp, WF, Vermeij, JD, van Geloven, N, Dippel, Diederik, Dijkgraaf, MGW, van der Poll, T, Prins, JM, Spanjaard, L, Vermeij, Frederique, Nederkoorn, PJ, and de Beek, DV

Abstract

Background: Stroke is a leading cause of death worldwide. Infections after stroke occur in 30% of stroke patients and are strongly associated with unfavourable outcome. Preventive antibiotic therapy lowers infection rate in patients after stroke, however, the effect of preventive antibiotic treatment on functional outcome after stroke has not yet been investigated. The Preventive Antibiotics in Stroke Study (PASS) is an ongoing, multicentre, prospective, randomised, open-label, blinded end point trial of preventive antibiotic therapy in acute stroke. Patients are randomly assigned to either ceftriaxone at a dose of 2 g, given every 24 hours intravenously for four-days, in addition to stroke-unit care, or standard stroke-unit care without preventive antibiotic therapy. Aim of the study is to assess whether preventive antibiotic treatment improves functional outcome at three months by preventing infections. Results: To date, 2,470 patients have been included in PASS. Median stroke severity of the first 2,133 patients (second interim analysis) is 5 (IQR 3 to 9) on the National Institutes of Health Stroke Scale (NIHSS). Due to the PROBE design, no outcome data are available yet. In the initial trial protocol we proposed a dichotomisation of the mRS as primary analysis of outcome and ordinal regression analysis as secondary analysis of primary outcome, requiring a sample size of 3,200 patients. However, ordinal analysis of outcome data is becoming increasingly more common in acute stroke trials, as it increases statistical power. For PASS, funding is insufficient for inclusion of 3,200 patients with the overall inclusion rate of 15 patients per week. Therefore we change the analysis of our primary outcome from dichotomisation to ordinal regression analysis on the mRS. Power analysis showed that with similar assumptions 2,550 patients are needed using ordinal regression analysis. We expect to complete follow-up in June 2014. A full statistical analysis plan will be submit

Published
2014

44. Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR.

Author

Luykx, JJ, Luykx, JJ, Bakker, SC, van Geloven, N, Eijkemans, MJC, Horvath, S, Lentjes, E, Boks, MPM, Strengman, E, DeYoung, J, Buizer-Voskamp, JE, Cantor, RM, Lu, A, van Dongen, EPA, Borgdorff, P, Bruins, P, Kahn, RS, Ophoff, RA, Luykx, JJ, Luykx, JJ, Bakker, SC, van Geloven, N, Eijkemans, MJC, Horvath, S, Lentjes, E, Boks, MPM, Strengman, E, DeYoung, J, Buizer-Voskamp, JE, Cantor, RM, Lu, A, van Dongen, EPA, Borgdorff, P, Bruins, P, Kahn, RS, and Ophoff, RA

Abstract

Studying monoaminergic seasonality is likely to improve our understanding of neurobiological mechanisms underlying season-associated physiological and pathophysiological behavior. Studies of monoaminergic seasonality and the influence of the serotonin-transporter-linked polymorphic region (5-HTTLPR) on serotonin seasonality have yielded conflicting results, possibly due to lack of power and absence of multi-year analyses. We aimed to assess the extent of seasonal monoamine turnover and examined the possible involvement of the 5-HTTLPR. To determine the influence of seasonality on monoamine turnover, 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured in the cerebrospinal fluid of 479 human subjects collected during a 3-year period. Cosine and non-parametric seasonal modeling were applied to both metabolites. We computed serotonin (5-HT) seasonality values and performed an association analysis with the s/l alleles of the 5-HTTLPR. Depressive symptomatology was assessed using the Beck Depression Inventory-II. Circannual variation in 5-HIAA fitted a spring-peak cosine model that was significantly associated with sampling month (P=0.0074). Season of sampling explained 5.4% (P=1.57 × 10(-7)) of the variance in 5-HIAA concentrations. The 5-HTTLPR s-allele was associated with increased 5-HIAA seasonality (standardized regression coefficient=0.12, P=0.020, N=393). 5-HIAA seasonality correlated with depressive symptoms (Spearman's rho=0.13, P=0.018, N=345). In conclusion, we highlight a dose-dependent association of the 5-HTTLPR with 5-HIAA seasonality and a positive correlation between 5-HIAA seasonality and depressive symptomatology. The presented data set the stage for follow-up in clinical populations with a role for seasonality, such as affective disorders.

Published
2013

45. Prognostic factors of motor impairment, disability, and quality of life in newly diagnosed PD

Author

Velseboer, D.C., Broeders, M., Post, B., Van Geloven, N., Speelman, J.D., Schmand, B.A., Haan, R.J. de, Bie, R.M. de, et al., Velseboer, D.C., Broeders, M., Post, B., Van Geloven, N., Speelman, J.D., Schmand, B.A., Haan, R.J. de, Bie, R.M. de, and et al.

Abstract

Item does not contain fulltext, OBJECTIVE: In Parkinson disease (PD), the rate of clinical progression is highly variable. To date, there are conflicting findings concerning the prognostic factors influencing the rate of progression. Methodologic issues such as the use of selected patients from therapeutic trials, and short durations of follow-up probably underlie this problem. We therefore designed a prospective follow-up study of a cohort of newly diagnosed patients with PD. METHODS: A cohort of 129 patients with newly diagnosed PD was assessed at baseline, and 1, 2, 3, and 5 years later. The rate of progression and its prognostic factors on the level of motor impairments, disability, and quality of life were investigated using linear mixed-model analysis. RESULTS: Annual increase of motor impairments measured with the Unified Parkinson's Disease Rating Scale-Motor Examination was estimated to be 2.46 points (95% confidence interval: 2.05-2.88). The main determinants of faster increase of motor impairments were male sex and cognitive dysfunction at the time of diagnosis. The main determinants of faster increase of disability were higher age at onset, cognitive dysfunction, and the presence of levodopa-nonresponsive motor symptoms at the time of diagnosis. No clinically relevant determinants were found for the decrease in quality of life. CONCLUSION: This study shows the importance of nondopaminergic symptoms at the time of diagnosis, because these symptoms are the main determinants of increased disability in the first 5 years of the disease.

Published
2013

46. Seasonal variation of serotonin turnover in human cerebrospinal fluid, depressive symptoms and the role of the 5-HTTLPR.

Author

Luykx, JJ, Luykx, JJ, Bakker, SC, van Geloven, N, Eijkemans, MJC, Horvath, S, Lentjes, E, Boks, MPM, Strengman, E, DeYoung, J, Buizer-Voskamp, JE, Cantor, RM, Lu, A, van Dongen, EPA, Borgdorff, P, Bruins, P, Kahn, RS, Ophoff, RA, Luykx, JJ, Luykx, JJ, Bakker, SC, van Geloven, N, Eijkemans, MJC, Horvath, S, Lentjes, E, Boks, MPM, Strengman, E, DeYoung, J, Buizer-Voskamp, JE, Cantor, RM, Lu, A, van Dongen, EPA, Borgdorff, P, Bruins, P, Kahn, RS, and Ophoff, RA

Abstract

Studying monoaminergic seasonality is likely to improve our understanding of neurobiological mechanisms underlying season-associated physiological and pathophysiological behavior. Studies of monoaminergic seasonality and the influence of the serotonin-transporter-linked polymorphic region (5-HTTLPR) on serotonin seasonality have yielded conflicting results, possibly due to lack of power and absence of multi-year analyses. We aimed to assess the extent of seasonal monoamine turnover and examined the possible involvement of the 5-HTTLPR. To determine the influence of seasonality on monoamine turnover, 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were measured in the cerebrospinal fluid of 479 human subjects collected during a 3-year period. Cosine and non-parametric seasonal modeling were applied to both metabolites. We computed serotonin (5-HT) seasonality values and performed an association analysis with the s/l alleles of the 5-HTTLPR. Depressive symptomatology was assessed using the Beck Depression Inventory-II. Circannual variation in 5-HIAA fitted a spring-peak cosine model that was significantly associated with sampling month (P=0.0074). Season of sampling explained 5.4% (P=1.57 × 10(-7)) of the variance in 5-HIAA concentrations. The 5-HTTLPR s-allele was associated with increased 5-HIAA seasonality (standardized regression coefficient=0.12, P=0.020, N=393). 5-HIAA seasonality correlated with depressive symptoms (Spearman's rho=0.13, P=0.018, N=345). In conclusion, we highlight a dose-dependent association of the 5-HTTLPR with 5-HIAA seasonality and a positive correlation between 5-HIAA seasonality and depressive symptomatology. The presented data set the stage for follow-up in clinical populations with a role for seasonality, such as affective disorders.

Published
2013

47. Prognostic factors of motor impairment, disability, and quality of life in newly diagnosed PD

Author

Velseboer, D.C., Broeders, M., Post, B., Van Geloven, N., Speelman, J.D., Schmand, B.A., Haan, R.J. de, Bie, R.M. de, et al., Velseboer, D.C., Broeders, M., Post, B., Van Geloven, N., Speelman, J.D., Schmand, B.A., Haan, R.J. de, Bie, R.M. de, and et al.

Abstract

Item does not contain fulltext, OBJECTIVE: In Parkinson disease (PD), the rate of clinical progression is highly variable. To date, there are conflicting findings concerning the prognostic factors influencing the rate of progression. Methodologic issues such as the use of selected patients from therapeutic trials, and short durations of follow-up probably underlie this problem. We therefore designed a prospective follow-up study of a cohort of newly diagnosed patients with PD. METHODS: A cohort of 129 patients with newly diagnosed PD was assessed at baseline, and 1, 2, 3, and 5 years later. The rate of progression and its prognostic factors on the level of motor impairments, disability, and quality of life were investigated using linear mixed-model analysis. RESULTS: Annual increase of motor impairments measured with the Unified Parkinson's Disease Rating Scale-Motor Examination was estimated to be 2.46 points (95% confidence interval: 2.05-2.88). The main determinants of faster increase of motor impairments were male sex and cognitive dysfunction at the time of diagnosis. The main determinants of faster increase of disability were higher age at onset, cognitive dysfunction, and the presence of levodopa-nonresponsive motor symptoms at the time of diagnosis. No clinically relevant determinants were found for the decrease in quality of life. CONCLUSION: This study shows the importance of nondopaminergic symptoms at the time of diagnosis, because these symptoms are the main determinants of increased disability in the first 5 years of the disease.

Published
2013

48. Chlamydia antibody testing and diagnosing tubal pathology in subfertile women : an individual patient data meta-analysis

Author

Broeze, KA, Opmeer, BC, Coppus, SFPJ, Van Geloven, N, Alves, MFC, Anestad, G, Bhattacharya, S, Allan, J, Guerra-Infante, MF, Den Hartog, JE, Land, JA, Idahl, Annika, Van der Linden, PJQ, Mouton, JW, Ng, EHY, Van der Steeg, JW, Steures, P, Svenstrup, HF, Tiitinen, A, Toye, B, Van der Veen, F, Mol, BW, Broeze, KA, Opmeer, BC, Coppus, SFPJ, Van Geloven, N, Alves, MFC, Anestad, G, Bhattacharya, S, Allan, J, Guerra-Infante, MF, Den Hartog, JE, Land, JA, Idahl, Annika, Van der Linden, PJQ, Mouton, JW, Ng, EHY, Van der Steeg, JW, Steures, P, Svenstrup, HF, Tiitinen, A, Toye, B, Van der Veen, F, and Mol, BW

Abstract

BACKGROUND The Chlamydia IgG antibody test (CAT) shows considerable variations in reported estimates of test accuracy, partly because of the use of different assays and cut-off values. The aim of this study was to reassess the accuracy of CAT in diagnosing tubal pathology by individual patient data (IPD) meta-analysis for three different CAT assays. METHODS We approached authors of primary studies that used micro-immunofluorescence tests (MIF), immunofluorescence tests (IF) or enzyme-linked immunosorbent assay tests (ELISA). Using the obtained IPD, we performed pooled receiver operator characteristics analysis and logistic regression analysis with a random effects model to compare the three assays. Tubal pathology was defined as either any tubal obstruction or bilateral tubal obstruction. RESULTS We acquired data of 14 primary studies containing data of 6191 women, of which data of 3453 women were available for analysis. The areas under the curve for ELISA, IF and MIF were 0.64, 0.65 and 0.75, respectively (P-value < 0.001) for any tubal pathology and 0.66, 0.66 and 0.77, respectively (P-value = 0.01) for bilateral tubal pathology. CONCLUSIONS In Chlamydia antibody testing, MIF is superior in the assessment of tubal pathology. In the initial screen for tubal pathology MIF should therefore be the test of first choice.

Published
2011
Full Text
View/download PDF

49. Chlamydia antibody testing and diagnosing tubal pathology in subfertile women: an individual patient data meta-analysis

Author

Broeze, K.A., Opmeer, B.C., Coppus, S.F., Van Geloven, N., Alves, M.F., Anestad, G., Bhattacharya, S., Allan, J., Guerra-Infante, M.F., Hartog, J.E. Den, Land, J.A., Idahl, A., Linden, P.J. van der, Mouton †, J.W., Ng, E.H., Steeg, J.W. van der, Steures, P., Svenstrup, H.F., Tiitinen, A., Toye, B., Veen, F. van der, Mol, B.W., Broeze, K.A., Opmeer, B.C., Coppus, S.F., Van Geloven, N., Alves, M.F., Anestad, G., Bhattacharya, S., Allan, J., Guerra-Infante, M.F., Hartog, J.E. Den, Land, J.A., Idahl, A., Linden, P.J. van der, Mouton †, J.W., Ng, E.H., Steeg, J.W. van der, Steures, P., Svenstrup, H.F., Tiitinen, A., Toye, B., Veen, F. van der, and Mol, B.W.

Abstract

Item does not contain fulltext, BACKGROUND: The Chlamydia IgG antibody test (CAT) shows considerable variations in reported estimates of test accuracy, partly because of the use of different assays and cut-off values. The aim of this study was to reassess the accuracy of CAT in diagnosing tubal pathology by individual patient data (IPD) meta-analysis for three different CAT assays. METHODS: We approached authors of primary studies that used micro-immunofluorescence tests (MIF), immunofluorescence tests (IF) or enzyme-linked immunosorbent assay tests (ELISA). Using the obtained IPD, we performed pooled receiver operator characteristics analysis and logistic regression analysis with a random effects model to compare the three assays. Tubal pathology was defined as either any tubal obstruction or bilateral tubal obstruction. RESULTS: We acquired data of 14 primary studies containing data of 6191 women, of which data of 3453 women were available for analysis. The areas under the curve for ELISA, IF and MIF were 0.64, 0.65 and 0.75, respectively (P-value < 0.001) for any tubal pathology and 0.66, 0.66 and 0.77, respectively (P-value = 0.01) for bilateral tubal pathology. CONCLUSIONS: In Chlamydia antibody testing, MIF is superior in the assessment of tubal pathology. In the initial screen for tubal pathology MIF should therefore be the test of first choice.

Published
2011

50. Progression and prognostic factors of motor impairment, disability and quality of life in newly diagnosed Parkinson's disease

Author

Post, B., Muslimovic, D., Van Geloven, N., Speelman, J.D., Schmand, B.A., Haan, R.J. de, Post, B., Muslimovic, D., Van Geloven, N., Speelman, J.D., Schmand, B.A., and Haan, R.J. de

Abstract

Item does not contain fulltext, OBJECTIVE: To determine progression and prognostic factors of progression rate of motor impairment, disability, and quality of life (QoL) in patients with newly diagnosed Parkinson's disease. METHODS: A group of 126 patients with newly diagnosed PD recruited from outpatient clinics participated in this 3-year prospective cohort study. Motor impairment was rated with the Unified Parkinson Disease Rating Scale Motor-Examination. Disability was rated using the Schwab and England Activities of Daily Living Scale, the AMC Linear Disability Score. QoL was assessed with the Parkinson's Disease Quality of Life questionnaire. Linear mixed model analyses were conducted to identify determinants of progression rate of motor impairment, disability, and poor QoL. RESULTS: Motor impairment progressed with 3 points per year. There was a slight progression of disability and QoL during 3 years of follow-up. Female sex was a prognostic factor for slower progression of motor impairment and QoL. Older age at onset showed to prognosticate faster progression of disability and impaired QoL. Furthermore, independent of follow-up time, older age at onset was associated with worse motor impairment; nondopaminergic reactive symptoms (Axial impairment) were associated with more disability and poorer QoL; comorbidity showed relation with disability and QoL but to a lesser extent; self-reported mood symptoms were associated with poorer QoL; and disease duration correlated with motor impairment. CONCLUSIONS: Motor impairment, disability, and QoL of newly diagnosed Parkinson patients show progression in the first 3 years. Older age at onset predicts worse progression rate of disability and impaired QoL over time. Female sex predicts slower progression of motor impairment and less decline of QoL.

Published
2011

Catalog

Books, media, physical & digital resources
See catalog results