1. Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
- Author
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Liang, T. Jake, Law, John L.M., Pietschmann, Thomas, Ray, Stuart C., Bukh, Jens, Bull, Rowena, Chung, Raymond T., Tyrrell, D. Lorne, Houghton, Michael, Rice, Charles M., Liang, T. Jake, Law, John L.M., Pietschmann, Thomas, Ray, Stuart C., Bukh, Jens, Bull, Rowena, Chung, Raymond T., Tyrrell, D. Lorne, Houghton, Michael, and Rice, Charles M.
- Abstract
For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.
- Published
- 2023