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A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.

A cyclam-based macrocyclic sensor has been prepared using synthetically simple "click" chemistry to link a fluorophore to the macrocyclic receptor. This sensor shows high selectivity for Zn(ll) over a range of other metals, providing a significant enhancement of fluorescence intensity over a wide pH range. As such, this is the first cyclam-based sensor demonstrated to be selective for Zn(ll) and is the first example of a triazole being used as a coordinating ligand on an azamacrocycle. The sensor can access biologically available zinc in mammalian cells, sensing the Zn(ll) flux that exists during apoptotic cell death. © 2009 American Chemical Society.

Starting from the iterative multi�]scaling approach previously studied for monochromatic illuminations, two multi�]resolution strategies for dealing with multi�]frequency inverse scattering experiments have been developed. The first procedure is based on the integration of the iterative multi�]scaling algorithm into a frequency�]hopping reconstruction scheme, while in the second one the multi�]frequency data are simultaneously processed exploiting a multi�]resolution expansion of the problem unknowns. The numerical and the experimental analysis presented in this contribution concern with a preliminary assessment of the reconstruction effectiveness of the proposed approaches in comparison with a monochromatic multi�]step process. This is the author's version of the final version available at IEEE.

Starting from the iterative multi�]scaling approach previously studied for monochromatic illuminations, two multi�]resolution strategies for dealing with multi�]frequency inverse scattering experiments have been developed. The first procedure is based on the integration of the iterative multi�]scaling algorithm into a frequency�]hopping reconstruction scheme, while in the second one the multi�]frequency data are simultaneously processed exploiting a multi�]resolution expansion of the problem unknowns. The numerical and the experimental analysis presented in this contribution concern with a preliminary assessment of the reconstruction effectiveness of the proposed approaches in comparison with a monochromatic multi�]step process. This is the author's version of the final version available at IEEE.