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Objective: We investigated the influence of abatacept (ABT) on bone mineral density (BMD) and bone metabolic markers (BMMs) in patients with rheumatoid arthritis (RA) compared to other biologic disease-modifying anti-rheumatic drugs (bDMARDs). / Methods: This prospective, comparative, non-randomized study (the AIRTIGHT study; UMIN000005570) investigated the effects of ABT and other bDMARDs on bone metabolism. A total of 165 RA patients were divided into ABT (n=50) and Non-ABT (n=115). We evaluated percentage changes in BMD (%ΔBMD) at the lumbar spine and femoral neck using dual-energy X-ray absorptiometry. Urinary levels of cross-linked N-telopeptide of type I collagen (uNTx) and bone-specific alkaline phosphatase (BAP) were used as markers of bone resorption and formation, respectively....

Objectives: This study aimed to clarify the relationship between body mass index (BMI) and patient characteristics, lifestyle factors, and cardiovascular disease (CVD)-related clinical data in women with rheumatoid arthritis (RA). Methods: A total of 171 female outpatients with RA and 170 age-matched females without RA (controls) from the TOMORROW study (UMIN: 000003876) were included in this cross-sectional study. We divided subjects into 3 groups based on BMI: underweight (BMI < 18.5 kg/m2), normal weight (BMI ≥ 18.5 kg/m2 and < 25 kg/m2), and overweight (BMI ≥25 kg/m2), and compared RA disease activity, activities of daily living (ADL) assessed by modified health assessment questionnaire (mHAQ) score, energy and nutrient intake, and CVD risk-related clinical data. Results: In patients with RA, mHAQ scores were lower in the normal weight group compared with the underweight and overweight groups (p < 0.05). Disease activity showed a similar trend. Energy, protein, and carbohydrate intake showed a positive correlation with BMI (p < 0.05). Blood pressure, C-reactive protein, uric acid, triglyceride, fasting plasma glucose, immune reactive insulin, HbA1c, and leptin showed a positive correlation with BMI, and adiponectin showed a negative correlation with BMI (p < 0.05). Control subjects showed similar trends. Conclusions: BMI is related to ADL, disease activity, energy, protein and carbohydrate intake, and CVD risk-related clinical data, and might be an indicator of total health status in female patients with RA.