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1. The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis

Author

Pan, Kuan-Yu, van Tuijl, Lonneke, Basten, Maartje, Rijnhart, Judith J M, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Hollander, Monika, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Picavet, Susan, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Twait, Emma L, van der Willik, Kimberly D, Lamers, Femke, Pan, Kuan-Yu, van Tuijl, Lonneke, Basten, Maartje, Rijnhart, Judith J M, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Hollander, Monika, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Picavet, Susan, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Twait, Emma L, van der Willik, Kimberly D, and Lamers, Femke

Abstract

BACKGROUND: Although behavioral mechanisms in the association among depression, anxiety, and cancer are plausible, few studies have empirically studied mediation by health behaviors. We aimed to examine the mediating role of several health behaviors in the associations among depression, anxiety, and the incidence of various cancer types (overall, breast, prostate, lung, colorectal, smoking-related, and alcohol-related cancers).METHODS: Two-stage individual participant data meta-analyses were performed based on 18 cohorts within the Psychosocial Factors and Cancer Incidence consortium that had a measure of depression or anxiety ( N = 319 613, cancer incidence = 25 803). Health behaviors included smoking, physical inactivity, alcohol use, body mass index (BMI), sedentary behavior, and sleep duration and quality. In stage one, path-specific regression estimates were obtained in each cohort. In stage two, cohort-specific estimates were pooled using random-effects multivariate meta-analysis, and natural indirect effects (i.e. mediating effects) were calculated as hazard ratios (HRs). RESULTS: Smoking (HRs range 1.04-1.10) and physical inactivity (HRs range 1.01-1.02) significantly mediated the associations among depression, anxiety, and lung cancer. Smoking was also a mediator for smoking-related cancers (HRs range 1.03-1.06). There was mediation by health behaviors, especially smoking, physical inactivity, alcohol use, and a higher BMI, in the associations among depression, anxiety, and overall cancer or other types of cancer, but effects were small (HRs generally below 1.01).CONCLUSIONS: Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.

Published
2024

2. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

3. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Cardiovasculaire Epidemiologie, MS Medische Oncologie, Planetary Health & Exposoom, Cancer, Circulatory Health, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Zorg, Cardiovasculaire Epi Team 5, Brain, Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Published
2024

4. Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis

Author

Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Geerlings, Mirjam I, Leerstoel Boelen, Trauma and Grief, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, Basten, Maartje, Pan, Kuan-Yu, van Tuijl, Lonneke A, de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W, Lamers, Femke, Ranchor, Adelita V, Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, and Geerlings, Mirjam I

Published
2024

5. Psychosocial factors, health behaviors and risk of cancer incidence:Testing interaction and effect modification in an individual participant data meta-analysis

Author

Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Geerlings, Mirjam I., Basten, Maartje, Pan, Kuan Yu, van Tuijl, Lonneke A., de Graeff, Alexander, Dekker, Joost, Hoogendoorn, Adriaan W., Lamers, Femke, Ranchor, Adelita V., Vermeulen, Roel, Portengen, Lützen, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., and Geerlings, Mirjam I.

Abstract

Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking and alcohol use, in relation to cancer incidence. Two-stage individual participant data meta-analyses were performed based on 22 cohorts of the PSYchosocial factors and CAncer (PSY-CA) study. We examined nine psychosocial factors (depression diagnosis, depression symptoms, anxiety diagnosis, anxiety symptoms, perceived social support, loss events, general distress, neuroticism, relationship status), seven health behaviors/behavior-related factors (smoking, alcohol use, physical activity, body mass index, sedentary behavior, sleep quality, sleep duration) and seven cancer outcomes (overall cancer, smoking-related, alcohol-related, breast, lung, prostate, colorectal). Effects of the psychosocial factor, health behavior and their product term on cancer incidence were estimated using Cox regression. We pooled cohort-specific estimates using multivariate random-effects meta-analyses. Additive and multiplicative interaction/effect modification was examined. This study involved 437,827 participants, 36,961 incident cancer diagnoses, and 4,749,481 person years of follow-up. Out of 744 combinations of psychosocial factors, health behaviors, and cancer outcomes, we found no evidence of interaction. Effect modification was found for some combinations, but there were no clear patterns for any particular factors or outcomes involved. In this first large study to systematically examine potential interaction and effect modification, we found no evidence for psychosocial factors to interact with or modify health behaviors in relation to cancer incidence. The behavioral risk profile for cancer incidence is similar in people with and without psychosocial stress.

Published
2024

6. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Abstract

BACKGROUND: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium.METHODS: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2).RESULTS: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06-1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04-1.23).CONCLUSIONS: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. PREREGISTRATION NUMBER: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

7. Depression, anxiety, and the risk of cancer:An individual participant data meta-analysis

Author

van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., Ranchor, Adelita V., van Tuijl, Lonneke A., Basten, Maartje, Pan, Kuan Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I., Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C., Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R., Keats, Melanie R., Kok, Almar A.L., Krokstad, Steinar, van Leeuwen, Flora E., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Rissanen, Ina, Roest, Annelieke M., Ruiter, Rikje, Schoevers, Robert A., Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Twait, Emma L., Teyhan, Alison, Verschuren, W. M.Monique, van der Willik, Kimberly D., Rosmalen, Judith G.M., and Ranchor, Adelita V.

Abstract

Background: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the Psychosocial Factors and Cancer Incidence (PSY-CA) consortium. Methods: The PSY-CA consortium includes data from 18 cohorts with measures of depression or anxiety (up to N = 319,613; cancer incidences, 25,803; person-years of follow-up, 3,254,714). Both symptoms and a diagnosis of depression and anxiety were examined as predictors of future cancer risk. Two-stage IPD meta-analyses were run, first by using Cox regression models in each cohort (stage 1), and then by aggregating the results in random-effects meta-analyses (stage 2). Results: No associations were found between depression or anxiety and overall, breast, prostate, colorectal, and alcohol-related cancers. Depression and anxiety (symptoms and diagnoses) were associated with the incidence of lung cancer and smoking-related cancers (hazard ratios [HRs], 1.06–1.60). However, these associations were substantially attenuated when additionally adjusting for known risk factors including smoking, alcohol use, and body mass index (HRs, 1.04–1.23). Conclusions: Depression and anxiety are not related to increased risk for most cancer outcomes, except for lung and smoking-related cancers. This study shows that key covariates are likely to explain the relationship between depression, anxiety, and lung and smoking-related cancers. Preregistration number: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=157677.

Published
2023

8. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Trauma and Grief, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, IRAS – One Health Chemical, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma L, Teyhan, Alison, Verschuren, W M Monique, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

9. Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

Author

Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, Ranchor, Adelita V, Cardiovasculaire Epidemiologie, MS Medische Oncologie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Brain, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 7a, Cardiometabolic Health, van Tuijl, Lonneke A, Basten, Maartje, Pan, Kuan-Yu, Vermeulen, Roel, Portengen, Lützen, de Graeff, Alexander, Dekker, Joost, Geerlings, Mirjam I, Hoogendoorn, Adriaan, Lamers, Femke, Voogd, Adri C, Abell, Jessica, Awadalla, Philip, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Frank, Philipp, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, de Jong, Trynke R, Keats, Melanie R, Kok, Almar A L, Krokstad, Steinar, van Leeuwen, Flora E, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Rissanen, Ina, Roest, Annelieke M, Ruiter, Rikje, Schoevers, Robert A, Soave, David, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Twait, Emma, Teyhan, Alison, Verschuren, MW, van der Willik, Kimberly D, Rosmalen, Judith G M, and Ranchor, Adelita V

Published
2023

10. Implementation of an Outpatient HD-MTX Initiative

Author

Sokol, Kelsey, Yuan, Kelley, Piddoubney, Maria, Sweeney, Ellen, Delengowski, Anne, Fendler, Katlin, Espinosa, Gloria M., Alberto, Judith, Galanis, Patricia, Gung, Carol, Stokley, Meghan, George, Mercy, Harris, Mary, Martinez-Outshoorn, Ubaldo E., Alpdogan, Onder, Porcu, Pierluigi, Binder, Adam, Sokol, Kelsey, Yuan, Kelley, Piddoubney, Maria, Sweeney, Ellen, Delengowski, Anne, Fendler, Katlin, Espinosa, Gloria M., Alberto, Judith, Galanis, Patricia, Gung, Carol, Stokley, Meghan, George, Mercy, Harris, Mary, Martinez-Outshoorn, Ubaldo E., Alpdogan, Onder, Porcu, Pierluigi, and Binder, Adam

Abstract

Introduction: Methotrexate (MTX) a folate antagonist is often given in high doses (≥500 mg/m2) to treat a variety of disease processes. While inpatient administration has been the norm, outpatient administration, has been shown to be safe, effective, and patient centered. Here in we describe development of an outpatient HDMTX protocol and our initial experience. Methods: All patients were to receive their first cycle of HDMTX in the hospital to ensure they tolerate it well and also to use this time to assist in training for home administration. The outpatient protocol involved continuous IV sodium bicarbonate, along with oral leucovorin and acetazolamide. Patients were required to visit the infusion center daily for labs and methotrexate levels. Clear criteria for admission were developed in the case of delayed clearance or methotrexate toxicity. Results: Two patients completed the safety run-in phase. Both patients tolerated treatment well. There were no associated toxicity. Methotrexate cleared within 3 days for all cycles. Both patients were able to follow the preadmission instructions for sodium bicarbonate and acetazolamide. The patients reported adequate teaching on the protocol and were able to maintain frequency of urine dipstick checks. Conclusion: We developed and implemented an outpatient protocol for high dose methotrexate. This study largely details the development of this protocol and its initial safety evaluation. More work needs to be done to assess its feasibility on a larger number of patients who receive more cycles in the outpatient setting.

Published
2022

11. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

OBJECTIVES: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer.METHODS: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2).CONCLUSION: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

12. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

13. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

14. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

15. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

16. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

17. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, Leerstoel Boelen, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Trauma and Grief, van Tuijl, Lonneke A, Voogd, Adri C, de Graeff, Alexander, Hoogendoorn, Adriaan W, Ranchor, Adelita V, Pan, Kuan-Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I, Abell, Jessica G, Awadalla, Philip, Bakker, Marije F, Beekman, Aartjan T F, Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R, Kok, Almar A L, Luik, Annemarie I, Noisel, Nolwenn, Onland-Moret, N Charlotte, Payette, Yves, Penninx, Brenda W J H, Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M, Rosmalen, Judith G M, Ruiter, Rikje, Schoevers, Robert A, Soave, David M, Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R, Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D, van Leeuwen, Flora E, van Petersen, Rutger, Verschuren, W M Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

18. Psychosocial factors and cancer incidence (PSY-CA):Protocol for individual participant data meta-analyses

Author

van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Abstract

Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.

Published
2021

19. Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses

Author

MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, Dekker, Joost, MS Medische Oncologie, Cancer, Cardiovasculaire Epi Team 7a, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Cardiovasculaire Epi Team 3, Cardiovasculaire Epi Team 5, Public Health Practice, Interne Geneeskunde Vasculaire, AIOS Psychiatrie, van Tuijl, Lonneke A., Voogd, Adri C., de Graeff, Alexander, Hoogendoorn, Adriaan W., Ranchor, Adelita V., Pan, Kuan Yu, Basten, Maartje, Lamers, Femke, Geerlings, Mirjam I., Abell, Jessica G., Awadalla, Philip, Bakker, Marije F., Beekman, Aartjan T.F., Bjerkeset, Ottar, Boyd, Andy, Cui, Yunsong, Galenkamp, Henrike, Garssen, Bert, Hellingman, Sean, Huisman, Martijn, Huss, Anke, Keats, Melanie R., Kok, Almar A.L., Luik, Annemarie I., Noisel, Nolwenn, Onland-Moret, N. Charlotte, Payette, Yves, Penninx, Brenda W.J.H., Portengen, Lützen, Rissanen, Ina, Roest, Annelieke M., Rosmalen, Judith G.M., Ruiter, Rikje, Schoevers, Robert A., Soave, David M., Spaan, Mandy, Steptoe, Andrew, Stronks, Karien, Sund, Erik R., Sweeney, Ellen, Teyhan, Alison, Vaartjes, Ilonca, van der Willik, Kimberly D., van Leeuwen, Flora E., van Petersen, Rutger, Verschuren, W. M.Monique, Visseren, Frank, Vermeulen, Roel, and Dekker, Joost

Published
2021

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