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Today, technology has entered into all business fields where the digital era is very helpfuland facilitates business both in terms of marketing, sales and distribution. The utilizationof these technologies will directly increase sales volume and the potential for anincreasingly large market. This will be very beneficial for medium and small businesses,where they still use a lot of conventional methods and have not used the technology sideand have not yet entered e-commerce. Expansion of the market or market is the mostimportant thing in the business world so that through E-Commerce, market coverage isno longer only in the area where the MSMEs are located but is widespread throughoutthe world wherever it can be accessed. In addition to the wider market, it can also accessreal-time payments that will facilitate the payment process directly by consumers andcan make the flow of cash out of the business more controlled which is no longer anobstacle. This online payment system is not always related to e-Commerce, but also withdirect transaction activities at the place of business can also be done so that cashless andalso in the online payment there will be a sales transaction report that will make therecording directly available in the payment system online. This benefit is very helpful forsmall and medium businesses that are expected to increase their sales growth and theirfinancial management will be helped.

Indonesia is an archipelagic nation which has a diverse tourist destination is quite interesting, whether it be of attractions, culinary, arts, cultural and natural charm. With so many places of this tourist destination, it can be developed into a promising business. By utilizing the marketing mix, namely Product, Price, Place, Promotion, People, Process and Physical evidence. Of the marketing mix can then be mapped to the matrix Ansoff for getting products that can be used as a business development strategy of tourism. This research was conducted with qualitative methods, namely by conducting interviews and observations to the tourism industry players. The results showed that the best business strategy is to do Product Diversification, ie change of market share by doing in combination with product changes. Another alternative is with the Market Penetration, Product Development or Market Development. With this strategy, is expected to obtain a good product at an affordable price by consumers. As well as increase the number of tourist arrivals in the regions in Indonesia. Moreover, it can empower all of the resources that are around attractions, both in terms of human resources and facilities.

The purpose of this research is to determine business model strategy of a company in the future, how does a company offers more to customers and maintain customers and everything related with business development. Business development is something required to be done by every company in order to be able to compete. This matter also happens in delivery service business. Delivery service business in Indonesia is very popular in Indonesia, wherein online delivery service business develops continuously, so delivery services also increase. But, this development must be followed by business model development, so the result will be satisfying for delivery service companies, especially in Jakarta. Research result shows that the best strategy is market penetration. Some alternatives that can be done are by enhancing resources by alliancy and coopetition, creating a competitive price scheme by mapping the cost from partner to obtain the best price, and also by doing promotion through several medias owned by the company, by ATL or BTL with the main purpose to increase selling.

Business can be done anywhere and by anyone. Where the purpose of a business for some people is different. Among others there are which aims to increase revenue. So with that reason, began to grow home-based business scale. Where businesses are done by the community and are planted in housing. One home-based business is the laundry. Laundry business kilogram is now very widespread, almost in every street can be found Landry. However, if carelessly in managing this business, then the business can be folded more quickly. So it takes some analysis, including marketing mix, where to open this business, you need to know the 4Ps. Product, Price, Place and Promotion. In addition to the marketing mix, it is necessary to do a SWOT. This research was conducted using quantitative and qualitative methods. Where data collection is done by observation and interviews with business owners, employees and customers. The results of this study will be able to look at the factors that influence the laundry as a home-based business with a view of the internal and external factors.

Indonesia is an archipelagic nation which has a diverse tourist destination is quite interesting, whether it be of attractions, culinary, arts, cultural and natural charm. With so many places of this tourist destination, it can be developed into a promising business. By utilizing the marketing mix, namely Product, Price, Place, Promotion, People, Process and Physical evidence. Of the marketing mix can then be mapped to the matrix Ansoff for getting products that can be used as a business development strategy of tourism. This research was conducted with qualitative methods, namely by conducting interviews and observations to the tourism industry players. The results showed that the best business strategy is to do Product Diversification, ie change of market share by doing in combination with product changes. Another alternative is with the Market Penetration, Product Development or Market Development. With this strategy, is expected to obtain a good product at an affordable price by consumers. As well as increase the number of tourist arrivals in the regions in Indonesia. Moreover, it can empower all of the resources that are around attractions, both in terms of human resources and facilities.

The purpose of this research is to determine business model strategy of a company in the future, how does a company offers more to customers and maintain customers and everything related with business development. Business development is something required to be done by every company in order to be able to compete. This matter also happens in delivery service business. Delivery service business in Indonesia is very popular in Indonesia, wherein online delivery service business develops continuously, so delivery services also increase. But, this development must be followed by business model development, so the result will be satisfying for delivery service companies, especially in Jakarta. Research result shows that the best strategy is market penetration. Some alternatives that can be done are by enhancing resources by alliancy and coopetition, creating a competitive price scheme by mapping the cost from partner to obtain the best price, and also by doing promotion through several medias owned by the company, by ATL or BTL with the main purpose to increase selling.

The functional role of ligand-gated ion channels in the central nervous system depends on their relative anion–cation permeability. Using standard whole-cell patchclamp measurements and NaCl dilution potential measurements, we explored the effect of external divalent ions on anion–cation selectivity in á1-homomeric wild-type glycine receptor channels. We show that increasing external Ca2+ from 0 to 4 mM resulted in a sigmoidal increase in anion–cation permeability by 37%, reaching a maximum above about 2 mM. Our accurate quantification of this effect required rigorous correction for liquid junction potentials (LJPs) using ion activities, and allowing for an initial offset potential. Failure to do this results in a considerable overestimation of the Ca2+-induced increase in anion–cation permeability by almost three-fold at 4 mM external Ca2+. Calculations of LJPs (using activities) were validated by precise agreement with direct experimental measurements. External SO4 2− was found to decrease anion–cation permeability. Single-channel conductance measurements indicated that external Ca2+ both decreased Na+ permeability and increased Cl− permeability. There was no evidence of Ca2+ changing channel pore diameter. Theoretical modeling indicates that the effect is not surface charge related. Rather, we propose that, under dilution conditions, the presence of an impermeant Ca2+ ion in the channel pore region just external to the selectivity filter tends to electrostatically retard outward movement of Na+ ions and to enhance movement of Cl− ions down their energy gradients.