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Background: Before 2016, patients with isolated synchronous colorectal peritoneal metastases (PMCRC) diagnosed in expert centers had a higher odds of undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) and better overall survival (OS) than those diagnosed in referring centers. Nationwide efforts were initiated to increase awareness and improve referral networks. Methods: This nationwide study aimed to evaluate whether the between-center differences in odds of undergoing CRS-HIPEC and OS have reduced since these national efforts were initiated. All patients with isolated synchronous PMCRC diagnosed between 2009 and 2021 were identified from the Netherlands Cancer Registry. Associations between hospital of diagnosis and the odds of undergoing CRS-HIPEC, as well as OS, were assessed using multilevel multivariable regression analyses for two periods (2009–2015 and 2016–2021). Results: In total, 3948 patients were included. The percentage of patients undergoing CRS-HIPEC increased from 17.2% in 2009–2015 (25.4% in expert centers, 16.5% in referring centers), to 23.4% in 2016–2021 (30.2% in expert centers, 22.6% in referring centers). In 2009–2015, compared with diagnosis in a referring center, diagnosis in a HIPEC center showed a higher odds of undergoing CRS-HIPEC (odds ratio [OR] 1.64, 95% confidence interval [CI] 1.02–2.67) and better survival (hazard ratio [HR] 0.80, 95% CI 0.66–0.96). In 2016–2021, there were no differences in the odds of undergoing CRS-HIPEC between patients diagnosed in HIPEC centers versus referring centers (OR 1.27, 95% CI 0.76–2.13) and survival (HR 1.00, 95% CI 0.76–1.32). Conclusion: Previously observed differences in odds of undergoing CRS-HIPEC were no longer present. Increased awareness and the harmonization of treatment for PMCRC may have contributed to equal access to care and a similar chance of survival at a national

We report direct observations of a fast magnetosonic forward-reverse shock pair observed by Solar Orbiter on 2022 March 8 at the short heliocentric distance of 0.5 au. The structure, sharing some features with fully-formed stream interaction regions, is due to the interaction between two successive coronal mass ejections (CMEs), never previously observed to give rise to a forward-reverse shock pair. The scenario is supported by remote observations from extreme ultraviolet cameras and coronagraphs, where two candidate eruptions compatible with the in situ signatures have been found. In the interaction region, we find enhanced energetic particle activity, strong nonradial flow deflections, and evidence of magnetic reconnection. At 1 au, well radially aligned Wind observations reveal a complex event, with characteristic observational signatures of both stream interaction region and CME-CME interaction, thus demonstrating the importance of investigating the complex dynamics governing solar eruptive phenomena.

PURPOSE: This study aimed to describe the 24-hour cycle of wearable sensor-obtained heart rate in patients with deterioration-free recovery and to compare it with patients experiencing postoperative deterioration.METHODS: A prospective observational trial was performed in patients following bariatric or major abdominal cancer surgery. A wireless accelerometer patch (Healthdot) continuously measured postoperative heart rate, both in the hospital and after discharge, for a period of 14 days. The circadian pattern, or diurnal rhythm, in the wearable sensor-obtained heart rate was described using peak, nadir and peak-nadir excursions.RESULTS: The study population consisted of 137 bariatric and 100 major abdominal cancer surgery patients. In the latter group, 39 experienced postoperative deterioration. Both surgery types showed disrupted diurnal rhythm on the first postoperative days. Thereafter, the bariatric group had significantly lower peak heart rates (days 4, 7-12, 14), lower nadir heart rates (days 3-14) and larger peak-nadir excursions (days 2, 4-14). In cancer surgery patients, significantly higher nadir (days 2-5) and peak heart rates (days 2-3) were observed prior to deterioration.CONCLUSIONS: The postoperative diurnal rhythm of heart rate is disturbed by different types of surgery. Both groups showed recovery of diurnal rhythm but in patients following cancer surgery, both peak and nadir heart rates were higher than in the bariatric surgery group. Especially nadir heart rate was identified as a potential prognostic marker for deterioration after cancer surgery.

Introduction:The peritoneum is the second most affected organ for the dissemination of colorectal cancer (CRC). Patients with colorectal peritoneal metastases (CPM) face a poor prognosis, despite the majority of patients being treated with palliative systemic therapy. The efficacy of palliative systemic therapy is limited due to the plasma-peritoneum barrier. The poor prognosis of unresectable CPM patients has resulted in the development of new treatment strategies where systemic therapy is combined with local, intraperitoneal chemotherapy. In the recently published phase I study, the maximum tolerated dose and thus the recommended phase II dose of intraperitoneal irinotecan was investigated and determined to be 75 mg. In the present study, the overall survival after treatment with 75 mg irinotecan with concomitant mFOLFOX4 and bevacizumab will be investigated. Materials and methods:In this single-arm phase II study in two Dutch tertiary referral centres, 85 patients are enrolled. Eligibility criteria are an adequate performance status and organ function, histologically confirmed microsatellite stable and unresectable CPM, no previous palliative therapy for CRC, no systemic therapy<6 months for CRC prior to enrolment and no previous cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS and HIPEC). Patients will undergo a diagnostic laparoscopy as standard work-up for CPM and if the peritoneal disease is considered unresectable (eg, Peritoneal Cancer Index (PCI)>20, too extensive small bowel involvement), a peritoneal access port and a port-a-cath are placed for administration of intraperitoneal and intravenous chemotherapy, respectively. Patients may undergo up to 12 cycles of study treatment. Each cycle consists of intravenous mFOLFOX4 with bevacizumab and concomitant intraperitoneal irinotecan (75 mg), which is repeated every 2 weeks, with a maximum of 12 cycles. Modified FOLFOX-4 regimen consists of 8

The combination of meaning-bearing units (e.g., words) into higher-order structures (e.g., compound words and phrases) is integral to human language. Despite this central role of syntax in language, little is known about its evolutionary progression. Comparative data using animal communication systems offer potential insights, but only a handful of species have been identified to combine meaningful calls together into larger signals. We investigated a candidate for syntax-like structure in the highly social chestnut-crowned babbler (Pomatostomus ruficeps). Using a combination of behavioral observations, acoustic analyses, and playback experiments, we test whether the form and function of maternal contact calls is modified by combining the core “piping” elements of such calls with at least one other call element or call. Results from the acoustic analyses (236 analysed calls from 10 individuals) suggested that piping call elements can be flexibly initiated with either “peow” elements from middle-distance contact calls or adult “begging” calls to form “peow-pipe” and “beg-pipe” calls. Behavioral responses to playbacks (20 trials to 7 groups) of natural peow-pipe and beg-pipe calls were comparable to those of artificially generated versions of each call using peow elements and begging calls from other contexts. Furthermore, responses to playbacks (34 trials to 7 groups) of the three forms of maternal contact calls (piping alone, peow-pipe, beg-pipe) differed. Together these data suggest that meaning encoded in piping calls is modified by combining such calls with begging calls or peow elements used in other contexts and so provide rare empirical evidence for syntactic-like structuring in a nonhuman animal.

It has recently become clear that some language-specific traits previously thought to be unique to humans (such as the capacity to combine sounds) are widespread in the animal kingdom. Despite the increase in studies documenting the presence of call combinations in non-human animals, factors promoting this vocal trait are unclear. One leading hypothesis proposes that communicative complexity co-evolved with social complexity owing to the need to transmit a diversity of information to a wider range of social partners. The Western Australian magpie (Gymnorhina tibicen dorsalis) provides a unique model to investigate this proposed link because it is a group-living, vocal learning species that is capable of multi-level combinatoriality (independently produced calls contain vocal segments and comprise combinations). Here, we compare variations in the production of call combinations across magpie groups ranging in size from 2 to 11 birds. We found that callers in larger groups give call combinations: (i) in greater diversity and (ii) more frequently than callers in smaller groups. Significantly, these observations support the hypothesis that combinatorial complexity may be related to social complexity in an open-ended vocal learner, providing an important step in understanding the role that sociality may have played in the development of vocal combinatorial complexity., It has recently become clear that some language-specific traits previously thought to be unique to humans (such as the capacity to combine sounds) are widespread in the animal kingdom. Despite the increase in studies documenting the presence of call combinations in non-human animals, factors promoting this vocal trait are unclear. One leading hypothesis proposes that communicative complexity co-evolved with social complexity owing to the need to transmit a diversity of information to a wider range of social partners. The Western Australian magpie (Gymnorhina tibicen dorsalis) provides a unique model to investigate this proposed link because it is a group-living, vocal learning species that is capable of multi-level combinatoriality (independently produced calls contain vocal segments and comprise combinations). Here, we compare variations in the production of call combinations across magpie groups ranging in size from 2 to 11 birds. We found that callers in larger groups give call combinations: (i) in greater diversity and (ii) more frequently than callers in smaller groups. Significantly, these observations support the hypothesis that combinatorial complexity may be related to social complexity in an open-ended vocal learner, providing an important step in understanding the role that sociality may have played in the development of vocal combinatorial complexity. This article is part of the theme issue 'The power of sound: unravelling how acoustic communication shapes group dynamics'.

Dermatomyositis is an inflammatory myopathy involving the skin that typically affects patients between 40-60 years of age and is more likely to be diagnosed in women. Around 10-20% of dermatomyositis cases present with subclinical or absent muscle involvement, termed "clinically amyopathic." Presence of anti-transcription intermediary factor 1? (TIF1?) antibodies is an important indicator of underlying malignancy. We present a patient with anti-TIF1? positive amyopathic dermatomyositis associated with bilateral breast cancer. The patient was safely treated with trastuzumab for breast cancer and intravenous immunoglobulin for dermatomyositis.

Analysis of biological evidence typically begins with a preliminary screening for the presence of biological fluids. Conventional enzymatic and immunological assays are of limited specificity and cannot conclusively identify the presence of several common biological fluids. RNA profiling is a new method for the identification of forensically relevant biological fluids, such as blood, saliva, semen, vaginal secretions and menstrual blood. Here, we provide an overview of the two different types of RNA profiling, particularly messenger RNA and micro RNA. The results of these studies are promising and suggest the future role of molecular-based approaches for the routine identification of the tissue source of origin of forensic biological evidence.

Drilling for the International Continental Scientific Drilling Program (ICDP) Early Jurassic Earth System and Timescale project (JET) was undertaken between October 2020 and January 2021. The drill site is situated in a small-scale synformal basin of the latest Triassic to Early Jurassic age that formed above the major Permian-Triassic half-graben system of the Cheshire Basin. The borehole is located to recover an expanded and complete succession to complement the legacy core from the Llanbedr (Mochras Farm) borehole drilled through 1967-1969 on the edge of the Cardigan Bay Basin, North Wales. The overall aim of the project is to construct an astronomically calibrated integrated timescale for the Early Jurassic and to provide insights into the operation of the Early Jurassic Earth system. Core of Quaternary age cover and Early Jurassic mudstone was obtained from two shallow partially cored geotechnical holes (Prees 2A to 32.2g¯m below surface (mg¯b.s.) and Prees 2B to 37.0g¯mg¯b.s.) together with Early Jurassic and Late Triassic mudstone from the principal hole, Prees 2C, which was cored from 32.92 to 651.32g¯m (corrected core depth scale). Core recovery was 99.7g¯% for Prees 2C. The ages of the recovered stratigraphy range from the Late Triassic (probably Rhaetian) to the Early Jurassic, Early Pliensbachian (Ibex Ammonoid Chronozone). All ammonoid chronozones have been identified for the drilled Early Jurassic strata. The full lithological succession comprises the Branscombe Mudstone and Blue Anchor formations of the Mercia Mudstone Group, the Westbury and Lilstock formations of the Penarth Group, and the Redcar Mudstone Formation of the Lias Group. A distinct interval of siltstone is recognized within the Late Sinemurian of the Redcar Mudstone Formation, and the name "Prees Siltstone Member"is proposed. Depositional environments range from playa lake in the Late Triassic to distal offshore marine in the Early Jurassic. Initial datasets compiled from the core in

Through syntax, i.e., the combination of words into larger phrases, language can express a limitless number of messages. Data in great apes, our closest-living relatives, are central to the reconstruction of syntax’s phylogenetic origins, yet are currently lacking. Here, we provide evidence for syntactic-like structuring in chimpanzee communication. Chimpanzees produce “alarm-huus” when surprised and “waa-barks” when potentially recruiting conspecifics during aggression or hunting. Anecdotal data suggested chimpanzees combine these calls specifically when encountering snakes. Using snake presentations, we confirm call combinations are produced when individuals encounter snakes and find that more individuals join the caller after hearing the combination. To test the meaning-bearing nature of the call combination, we use playbacks of artificially-constructed call combinations and both independent calls. Chimpanzees react most strongly to call combinations, showing longer looking responses, compared with both independent calls. We propose the “alarm-huu + waa-bark” represents a compositional syntactic-like structure, where the meaning of the call combination is derived from the meaning of its parts. Our work suggests that compositional structures may not have evolved de novo in the human lineage, but that the cognitive building-blocks facilitating syntax may have been present in our last common ancestor with chimpanzees.

Redesigning the European food system on the basis of circularity principles could bring environmental benefits for Europe and the world. Here we deploy a biophysical optimization model to explore the effects of adopting three circularity scenarios in the European Union (EU)27 + UK. We calculate a potential reduction of 71% in agricultural land use and 29% per capita in agricultural greenhouse gas emissions, while producing enough healthy food within a self-sufficient European food system. Under global food shortages, savings in agricultural land could be used to feed an additional 767 million people outside the EU (+149%), while reducing per capita greenhouse gas emissions by 38% but increasing overall emissions by 55% due to the increased population served. Transitioning the EU’s food system towards circularity implies sequential changes among all its components and has great potential to safeguard human and planetary health.

Introduction: Metabolic syndrome is a modern world's major health hazard related to comorbidities like type 2 diabetes and cardiovascular disease. Bariatric surgery is well known to lower this health risk in patients with obesity. There is a need for an objective measure to assess the intended reduction in health hazard and indirectly the eligibility for bariatric surgery. The Metabolic Health Index (MHI) quantitatively summarizes the cumulative impact of the metabolic syndrome on health status on a scale from 1 to 6. This study describes the use of the MHI as a supportive tool in the decision for and outcome assessment of bariatric surgery. Methods: The general usability of the MHI was tested by extending its application to patient data of five other bariatric centers in the Netherlands. Retrospective laboratory and national bariatric quality registry data of 11,501 patients were collected. Results: The quantification of (improvement in) metabolic health burden as measured by the MHI was independent of the dataset that was used to derive the MHI model. Patients with MHI > 2.8 prior to surgery improved significantly more in MHI 12 mo after surgery compared to patients with MHI ≤ 2.8 (1.1 compared to 0.4 MHI points, respectively; P < 0.001). Conclusions: The MHI is robust between centers and is suitable for general use in clinical decision-making. As changes in MHI over time reflect metabolic health alterations, it is suitable as an outcome measure of surgery. An MHI cut-off value of 2.8 helps to predict the likelihood of significant improvement after surgery, independent of body mass index and known metabolic comorbidities.

We present observations and modeling results of the propagation and impact at Earth of a high-latitude, extended filament channel eruption that commenced on 2015 July 9. The coronal mass ejection (CME) that resulted from the filament eruption was associated with a moderate disturbance at Earth. This event could be classified as a so-called "problem storm" because it lacked the usual solar signatures that are characteristic of large, energetic, Earth-directed CMEs that often result in significant geoeffective impacts. We use solar observations to constrain the initial parameters and therefore to model the propagation of the 2015 July 9 eruption from the solar corona up to Earth using 3D magnetohydrodynamic heliospheric simulations with three different configurations of the modeled CME. We find the best match between observed and modeled arrival at Earth for the simulation run that features a toroidal flux rope structure of the CME ejecta, but caution that different approaches may be more or less useful depending on the CME-observer geometry when evaluating the space weather impact of eruptions that are extreme in terms of their large size and high degree of asymmetry. We discuss our results in the context of both advancing our understanding of the physics of CME evolution and future improvements to space weather forecasting., Comment: 20 pages, 8 figures, 2 tables, accepted for publication in The Astrophysical Journal

Based on the APOGEE survey we conducted a search for carbon-deficient red giants (CDGs). We found 103 new CDGs, increasing the number in the literature by more than a factor of 3. CDGs are very rare, representing $0.03$~per cent of giants. They appear as an extended tail off the normal carbon distribution. We show that they are found in all components of the Galaxy, contrary to previous findings. The location of CDGs in the Hertzsprung-Russell diagram (HRD) shows that they are primarily intermediate-mass stars ($2-4~\rm{M}_{\odot}$). Their extended distribution may indicate that CDGs can also sometimes have $M < 2.0~\rm{M}_{\odot}$. We attempted to identify the evolutionary phases of the CDGs using stellar model tracks. We found that the bulk of the CDGs are likely in the subgiant branch or red clump phase, whereas other CDGs may be in the red giant branch or early asymptotic giant branch phases. Degeneracy in the HRD makes exact identification difficult. We examined their C, N, and O compositions and confirmed previous studies showing that the envelope material has undergone extensive hydrogen burning through the CN(O) cycle. The new-CDGs have [C+N+O/Fe] that generally sum to zero, indicating that they started with scaled-solar composition. However, the previously known-CDGs generally have [C+N+O/Fe$] > 0.0$, indicating that some He-burning products were added to their envelopes. As to the site(s) in which this originally occurred, we do not find a convincing solution., Comment: 12 pages, 5 figures, accepted by MNRAS

Carbon-deficient red giants (CDGs) are a peculiar class of stars that have eluded explanation for decades. We aim to better characterise CDGs by using asteroseismology (Kepler, TESS) combined with spectroscopy (APOGEE, LAMOST), and astrometry (Gaia). We discovered 15 new CDGs in the Kepler field, and confirm that CDGs are rare, being only $0.15\%$ of our background sample. Remarkably, we find that our CDGs are almost exclusively in the red clump (RC) phase. Asteroseismic masses reveal that our CDGs are primarily low-mass stars ($M \lesssim$ 2~M$_{\odot}$), in contrast to previous studies which suggested they are intermediate mass ($M = 2.5 - 5.0~\rm M_{\odot}$) based on HR diagrams. A very high fraction of our CDGs ($50\%$) are also Li-rich giants. We observe a bimodal distribution of luminosity in our CDGs, with one group having normal RC luminosity and the other being a factor of two more luminous than expected for their masses. We find demarcations in chemical patterns and luminosities which lead us to split them into three groups: (i) normal-luminosity CDGs, (ii) over-luminous CDGs, and (iii) over-luminous highly-polluted CDGs. We conclude that a merger of a helium white dwarf with an RGB star is the most likely scenario for the two groups of over-luminous stars. Binary mass-transfer from intermediate-mass AGB stars is a possibility for the highly-polluted over-luminous group. For the normal-luminosity CDGs, we cannot distinguish between core He-flash pollution or lower-mass merger scenarios. Due to the overlap with the CDGs, Li-rich giants may have similar formation channels., Comment: 27 pages, 14 figures, accepted by ApJ

Asteroseismology provides a new avenue for accurately measuring the masses of evolved globular cluster (GC) stars through the detection of their solar-like oscillations. We present the first detections of solar-like oscillations in 47 red giant branch (RGB) and early asymptotic giant branch (EAGB) stars in the metal-poor GC M80; only the second ever with measured seismic masses. We investigate two major areas of stellar evolution and GC science; the multiple populations and stellar mass-loss. We detected a distinct bimodality in the EAGB mass distribution. We showed that this is likely due to sub-population membership. If confirmed, it would be the first direct measurement of a mass difference between sub-populations. A mass difference was not detected between the sub-populations in our RGB sample. We instead measured an average RGB mass of $0.782\pm0.009~\msun$, which we interpret as the average between the sub-populations. Differing mass-loss rates on the RGB has been proposed as the second parameter that could explain the horizontal branch (HB) morphology variations between GCs. We calculated an integrated RGB mass-loss separately for each sub-population: $0.12\pm0.02~\msun$ (SP1) and $0.25\pm0.02~\msun$ (SP2). Thus, SP2 stars have greatly enhanced mass-loss on the RGB. Mass-loss is thought to scale with metallicity, which we confirm by comparing our results to a higher metallicity GC, M4. We also find that M80 stars have insignificant mass-loss on the HB. This is different to M4, suggesting that there is a metallicity and temperature dependence in the HB mass-loss. Finally, our study shows the robustness of the $\Delta\nu$-independent mass scaling relation in the low-metallicity (and low-surface gravity) regime., Comment: 20 pages, 11 figures

We have investigated how the degree of imbalance in solar wind turbulence is modified by large-scale velocity shears in the solar wind plasma. The balance between counterpropagating Alfv\'enic fluctuations, which interact nonlinearly to generate the turbulence, has been quantified by the cross helicity and Elsasser ratio. Velocity shears at a 30-min timescale were identified, with the shear amplitude defined in terms of the linear Kelvin-Helmholtz (KH) instability threshold. The shears were associated with 74 interplanetary coronal mass ejection (ICME) sheaths observed by the Wind spacecraft at 1 au between 1997 and 2018. Typically weaker shears upstream of the sheaths and downstream in the ICME ejecta were also analyzed. In shears below the KH threshold, imbalance was approximately invariant or weakly rising with shear amplitude. Above the KH threshold, fluctuations tended toward a balanced state with increasing shear amplitude. Magnetic compressibility was also found to increase above the KH threshold. These findings are consistent with velocity shears being local sources of sunward fluctuations that act to reduce net imbalances in the antisunward direction, and suggest that the KH instability plays a role in this process., Comment: 9 pages, 5 figures, accepted for publication in the Astrophysical Journal Letters 2023 March 2

Background: Remote monitoring is increasingly used to support postoperative care. This study aimed to describe the lessons learned from the use of telemonitoring in an outpatient bariatric surgery pathway. Materials and Methods: Patients were assigned based on their preference to an intervention cohort of same-day discharge after bariatric surgery. In total, 102 patients were monitored continuously for 7 days using a wearable monitoring device with a Continuous and Remote Early Warning Score–based notification protocol (CREWS). Outcome measures included missing data, course of postoperative heart and respiration rate, false positive notification and specificity analysis, and vital sign assessment during teleconsultation. Results: In 14.7% of the patients, data for heart rate was missing for > 8 h. A day-night-rhythm of heart rate and respiration rate reappeared on average on postoperative day 2 with heart rate amplitude increasing after day 3. CREWS notification had a specificity of 98%. Of the 17 notifications, 70% was false positive. Half of them occurred between day 4 and 7 and were accompanied with surrounding reassuring values. Comparable postoperative complaints were encountered between patients with normal and deviated data. Conclusion: Telemonitoring after outpatient bariatric surgery is feasible. It supports clinical decisions, however does not replace nurse or physician care. Although infrequent, the false notification rate was high. We suggested additional contact may not be necessary when notifications occur after restoration of circadian rhythm or when surrounding reassuring vital signs are present. CREWS supports ruling out serious complications, what may reduce in-hospital re-evaluations. Following these lessons learned, increased patients’ comfort and decreased clinical workload could be expected. Trial Registration: ClinicalTrials.gov. Identifier: NCT04754893. Graphical Abstract: [Figure not available: see fulltext.]

INTRODUCTION: The shift toward remote patient monitoring methods to detect clinical deterioration requires testing of wearable devices in real-life clinical settings. This study aimed to develop a remote early warning scoring (REWS) system based on continuous measurements using a wearable device, and compare its diagnostic performance for the detection of deterioration to the diagnostic performance of the conventional modified early warning score (MEWS).MATERIALS AND METHODS: The study population of this prospective, single center trial consisted of patients who underwent major abdominal cancer surgery and were monitored using routine in-hospital spotcheck measurements of the vital parameters. Heart and respiratory rates were measured continuously using a wireless accelerometer patch (HealthDot). The prediction by MEWS of deterioration toward a complication graded Clavien-Dindo of 2 or higher was compared to the REWS derived from continuous measurements by the wearable patch.MAIN RESULTS: A total of 103 patients and 1909 spot-check measurements were included in the analysis. Postoperative deterioration was observed in 29 patients. For both EWS systems, the sensitivity (MEWS: 0.20 95% CI: [0.13-0.29], REWS: 0.20 95% CI: [0.13-0.29]) and specificity (MEWS: 0.96 95% CI: [0.95-0.97], REWS: 0.96 95% CI: [0.95-0.97]) were assessed.CONCLUSIONS: The diagnostic value of the REWS method, based on continuous measurements of the heart and respiratory rates, is comparable to that of the MEWS in patients following major abdominal cancer surgery. The wearable patch could detect the same amount of deteriorations, without requiring manual spot check measurements.

Comparative studies conducted over the past few decades have provided important insights into the capacity for animals to combine vocal segments at either one of two levels: within- or between-calls. There remains, however, a distinct gap in knowledge as to whether animal combinatoriality can extend beyond one level. Investigating this requires a comprehensive analysis of the combinatorial features characterizing a species' vocal system. Here, we used a nonlinear dimensionality reduction analysis and sequential transition analysis to quantitatively describe the non-song combinatorial repertoire of the Western Australian magpie (Gymnorhina tibicen dorsalis). We found that (i) magpies recombine four distinct acoustic segments to create a larger number of calls, and (ii) the resultant calls are further combined into larger call combinations. Our work demonstrates two levels in the combining of magpie vocal units. These results are incongruous with the notion that a capacity for multi-level combinatoriality is unique to human language, wherein the combining of meaningless sounds and meaningful words interactively occurs across different combinatorial levels. Our study thus provides novel insights into the combinatorial capacities of a non-human species, adding to the growing evidence of analogues of language-specific traits present in the animal kingdom., Comparative studies conducted over the past few decades have provided important insights into the capacity for animals to combine vocal segments at either one of two levels: within- or between-calls. There remains, however, a distinct gap in knowledge as to whether animal combinatoriality can extend beyond one level. Investigating this requires a comprehensive analysis of the combinatorial features characterizing a species' vocal system. Here, we used a nonlinear dimensionality reduction analysis and sequential transition analysis to quantitatively describe the non-song combinatorial repertoire of the Western Australian magpie (Gymnorhina tibicen dorsalis). We found that (i) magpies recombine four distinct acoustic segments to create a larger number of calls, and (ii) the resultant calls are further combined into larger call combinations. Our work demonstrates two levels in the combining of magpie vocal units. These results are incongruous with the notion that a capacity for multi-level combinatoriality is unique to human language, wherein the combining of meaningless sounds and meaningful words interactively occurs across different combinatorial levels. Our study thus provides novel insights into the combinatorial capacities of a non-human species, adding to the growing evidence of analogues of language-specific traits present in the animal kingdom.

The potential for aggression is inherent in social interaction, and strategies to reduce the costs of aggression are ubiquitous among group-living animals. One strategy employed by lower-ranking individuals in a variety of species is the production of subordination signals, which are formal signals that communicate the signaler’s inferior status relative to the recipient of the signal. Here, we report the results of our investigations into (1) the presence and usage of the pant-grunt vocalization in two populations of wild bonobos; (2) the relationship between the production of pant-grunts and agonistic predictability across the genusPan. We find stark differences in production of pant-grunts in the two populations: bonobos at the LuiKotale field site regularly used pant-grunts as a signal of subordination (primarily, though not exclusively, among male-male dyads); in contrast, at the Kokolopori field site, adult bonobos were never observed producing pant-grunts. AcrossPan, we find weak support for an association between agonistic predictability and production of pant-grunt vocalizations.Significance statementThere have been conflicting reports on whether bonobos, like chimpanzees, produce the submissive pant-grunt vocalization. We confirm the presence of the pant-grunt in the bonobo vocal repertoire, and document variation in its production across communities. We also suggest that variation in pant-grunt production across the genusPanmay be explained by the predictability of dominance interactions.

Through syntax, i.e., the combination of words into larger phrases, language can express a limitless number of messages. Data in great apes, our closest-living relatives, are central to the reconstruction of syntax’s phylogenetic origins, yet are currently lacking. Here, we provide evidence for syntactic-like structuring in chimpanzee communication. Chimpanzees produce “alarm-huus” when surprised and “waa-barks” when potentially recruiting conspecifics during aggression or hunting. Anecdotal data suggested chimpanzees combine these calls specifically when encountering snakes. Using snake presentations, we confirm call combinations are produced when individuals encounter snakes and find that more individuals join the caller after hearing the combination. To test the meaning-bearing nature of the call combination, we use playbacks of artificially-constructed call combinations and both independent calls. Chimpanzees react most strongly to call combinations, showing longer looking responses, compared with both independent calls. We propose the “alarm-huu + waa-bark” represents a compositional syntactic-like structure, where the meaning of the call combination is derived from the meaning of its parts. Our work suggests that compositional structures may not have evolved de novo in the human lineage, but that the cognitive building-blocks facilitating syntax may have been present in our last common ancestor with chimpanzees.

A critical component of language is the ability to recombine sounds into larger structures. Although animals also reuse sound elements across call combinations to generate meaning, examples are generally limited to pairs of distinct elements, even when repertoires contain sufficient sounds to generate hundreds of combinations. This combinatoriality might be constrained by the perceptual-cognitive demands of disambiguating between complex sound sequences that share elements. We test this hypothesis by probing the capacity of chestnut-crowned babblers to process combinations of two versus three distinct acoustic elements. We found babblers responded quicker and for longer toward playbacks of recombined versus familiar bi-element sequences, but no evidence of differential responses toward playbacks of recombined versus familiar tri-element sequences, suggesting a cognitively prohibitive jump in processing demands. We propose that overcoming constraints in the ability to process increasingly complex combinatorial signals was necessary for the productive combinatoriality that is characteristic of language to emerge.

Comparative studies conducted over the past few decades have provided important insights into the capacity for animals to combine vocal segments at either one of two levels: within- or between-calls. There remains, however, a distinct gap in knowledge as to whether animal combinatoriality can extend beyond one level. Investigating this requires a comprehensive analysis of the combinatorial features characterizing a species' vocal system. Here, we used a nonlinear dimensionality reduction analysis and sequential transition analysis to quantitatively describe the non-song combinatorial repertoire of the Western Australian magpie (Gymnorhina tibicen dorsalis). We found that (i) magpies recombine four distinct acoustic segments to create a larger number of calls, and (ii) the resultant calls are further combined into larger call combinations. Our work demonstrates two levels in the combining of magpie vocal units. These results are incongruous with the notion that a capacity for multi-level combinatoriality is unique to human language, wherein the combining of meaningless sounds and meaningful words interactively occurs across different combinatorial levels. Our study thus provides novel insights into the combinatorial capacities of a non-human species, adding to the growing evidence of analogues of language-specific traits present in the animal kingdom.

Domestication dramatically changes behaviour, including communication, as seen in the case of dogs (Canis familiaris) and wolves (Canis lupus). We tested the hypothesis that domestication may affect an ancient, shared communication form of canids, the howling which seems to have higher individual variation in dogs: the perception and usage of howls may be affected by the genetic relatedness of the breeds to their last common ancestor with wolves (‘root distance’) and by other individual features like age, sex, and reproductive status. We exposed 68 purebred dogs to wolf howl playbacks and recorded their responses. We identified an interaction between root distance and age on the dogs’ vocal and behavioural responses: older dogs from more ancient breeds responded longer with howls and showed more stress behaviours. Our results suggest that domestication impacts vocal behaviour significantly: disintegrating howling, a central, species-specific communication form of canids and gradually eradicating it from dogs’ repertoire.

Drilling for the International Continental Scientific Drilling Program (ICDP) Early Jurassic Earth System and Timescale project (JET) was undertaken between October 2020 and January 2021. The drill site is situated in a small-scale synformal basin of the latest Triassic to Early Jurassic age that formed above the major Permian-Triassic half-graben system of the Cheshire Basin. The borehole is located to recover an expanded and complete succession to complement the legacy core from the Llanbedr (Mochras Farm) borehole drilled through 1967-1969 on the edge of the Cardigan Bay Basin, North Wales. The overall aim of the project is to construct an astronomically calibrated integrated timescale for the Early Jurassic and to provide insights into the operation of the Early Jurassic Earth system. Core of Quaternary age cover and Early Jurassic mudstone was obtained from two shallow partially cored geotechnical holes (Prees 2A to 32.2g¯m below surface (mg¯b.s.) and Prees 2B to 37.0g¯mg¯b.s.) together with Early Jurassic and Late Triassic mudstone from the principal hole, Prees 2C, which was cored from 32.92 to 651.32g¯m (corrected core depth scale). Core recovery was 99.7g¯% for Prees 2C. The ages of the recovered stratigraphy range from the Late Triassic (probably Rhaetian) to the Early Jurassic, Early Pliensbachian (Ibex Ammonoid Chronozone). All ammonoid chronozones have been identified for the drilled Early Jurassic strata. The full lithological succession comprises the Branscombe Mudstone and Blue Anchor formations of the Mercia Mudstone Group, the Westbury and Lilstock formations of the Penarth Group, and the Redcar Mudstone Formation of the Lias Group. A distinct interval of siltstone is recognized within the Late Sinemurian of the Redcar Mudstone Formation, and the name "Prees Siltstone Member"is proposed. Depositional environments range from playa lake in the Late Triassic to distal offshore marine in the Early Jurassic. Initial datasets compiled from the core in

This paper studies modulation spectrum features ($\Phi$) and mel-frequency cepstral coefficients ($\Psi$) in joint speaker diarization and identification (JSID). JSID is important as speaker diarization on its own to distinguish speakers is insufficient for many applications, it is often necessary to identify speakers as well. Machine learning models are set up using convolutional neural networks (CNNs) on $\Phi$ and recurrent neural networks $\unicode{x2013}$ long short-term memory (LSTMs) on $\Psi$, then concatenating into fully connected layers. Experiment 1 shows models on both $\Phi$ and $\Psi$ have better diarization error rates (DERs) than models on either alone; a CNN on $\Phi$ has DER 29.09\%, compared to 27.78\% for a LSTM on $\Psi$ and 19.44\% for a model on both. Experiment 1 also investigates aleatoric uncertainties and shows the model on both $\Phi$ and $\Psi$ has mean entropy 0.927~bits (out of 4~bits) for correct predictions compared to 1.896~bits for incorrect predictions which, along with entropy histogram shapes, shows the model helpfully indicates where it is uncertain. Experiment 2 investigates epistemic uncertainties as well as aleatoric using Monte Carlo dropout (MCD). It compares models on both $\Phi$ and $\Psi$ with models trained on x-vectors ($X$), before applying Kalman filter smoothing on epistemic uncertainties for resegmentation and model ensembles. While the two models on $X$ (DERs 10.23\% and 9.74\%) outperform those on $\Phi$ and $\Psi$ (DER 17.85\%) after their individual Kalman filter smoothing, combining them using a Kalman filter smoothing method improves the DER to 9.29\%. Aleatoric uncertainties are higher for incorrect predictions. Both Experiments show models on $\Phi$ do not distinguish overlapping speakers as well as anticipated. However, Experiment 2 shows model ensembles do better with overlapping speakers than individual models do., Comment: 12 pages, 7 figures

Tissue vibrations in the larynx produce most sounds that comprise vocal communication in mammals. Larynx morphology is thus predicted to be a key target for selection, particularly in species with highly developed vocal communication systems. Here, we present a novel database of digitally modeled scanned larynges from 55 different mammalian species, representing a wide range of body sizes in the primate and carnivoran orders. Using phylogenetic comparative methods, we demonstrate that the primate larynx has evolved more rapidly than the carnivoran larynx, resulting in a pattern of larger size and increased deviation from expected allometry with body size. These results imply fundamental differences between primates and carnivorans in the balance of selective forces that constrain larynx size and highlight an evolutionary flexibility in primates that may help explain why we have developed complex and diverse uses of the vocal organ for communication.

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Introduction: Performing bariatric surgery in a daycare setting has a potential reduction in hospital costs and increase in patients’ satisfaction. Although the feasibility and safety of such care pathway has already been proven, its implementation is hampered by concerns about timely detection of short-term complications. This study is designed to evaluate a combined outcome measurement in outpatient bariatric surgery supplemented by a novel wireless remote monitoring system versus current standard of care. Methods and analysis: A total of 200 patients with multidisciplinary team approval for primary bariatric surgery will be assigned based on their preference to one of two postoperative trajectories: (1) standard of in-hospital care with discharge on the first postoperative day or (2) same day discharge with ongoing telemonitoring up to 7 days after surgery. The device (Healthdot R Philips) transfers heart rate, respiration rate, activity, and body posture of the patient continuously by LoRaWan network to our hospital’s dashboard (Philips Guardian). The primary outcome is a composite outcome measure within 30 days postoperative based on mortality, mild and severe complications, readmission, and prolonged length-of-stay. Secondary outcomes include patients’ satisfaction and data handling dimensions. Trial registration: ClinicalTrials.govNCT04754893, Registered on 12 February 2021.

INTRODUCTION: Recent advances in wearable technology allow for the development of wirelessly connected sensors to continuously measure vital parameters in the general ward or even at home. The present study assesses the accuracy of a wearable patch (Healthdot) for continuous monitoring of heartrate (HR) and respiration rate (RR).MATERIALS AND METHODS: The Healthdot measures HR and RR by means of chest accelerometry. The study population consisted of patients following major abdominal oncological surgery. The analysis focused on the agreement between HR and RR measured by the Healthdot and the gold standard patient monitor in the intensive and post-anesthesia care unit.RESULTS: For HR, a total of 112 h of measurements was collected in 26 patients. For RR, a total of 102 h of measurements was collected in 21 patients. On second to second analysis, 97% of the HR and 87% of the RR measurements were within 5 bpm and 3 rpm of the reference monitor. Assessment of 5-min averaged data resulted in 96% of the HR and 95% of the RR measurements within 5 bpm and 3 rpm of the reference monitor. A Clarke error grid analysis showed that 100% of the HR and 99.4% of the 5-min averaged data was clinically acceptable.CONCLUSION: The Healthdot accurately measured HR and RR in a cohort of patients recovering from major abdominal surgery, provided that good quality data was obtained. These results push the Healthdot forward as a clinically acceptable tool in low acuity settings for unobtrusive, automatic, wireless and continuous monitoring.