Author: "Signori A" / Publication Type: Electronic Resources - Searchworks@Jio Institute Digital Library Search Results

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358 results on '"Signori A"'

1. Atezolizumab, venetoclax, and obinutuzumab combination in Richter transformation diffuse large B-cell lymphoma (MOLTO): a multicentre, single-arm, phase 2 trial

Author: Tedeschi, A, Frustaci, A, Condoluci, A, Coscia, M, Chiarle, R, Zinzani, P, Motta, M, Gaidano, G, Quaresmini, G, Scarfò, L, Catania, G, Deodato, M, Jones, R, Tabanelli, V, Griggio, V, Stüssi, G, Calleri, A, Pini, K, Cairoli, R, Zenz, T, Signori, A, Zucca, E, Rossi, D, Montillo, M, Tedeschi, Alessandra, Frustaci, Anna Maria, Condoluci, Adalgisa, Coscia, Marta, Chiarle, Roberto, Zinzani, Pier Luigi, Motta, Marina, Gaidano, Gianluca, Quaresmini, Giulia, Scarfò, Lydia, Catania, Gioacchino, Deodato, Marina, Jones, Rebecca, Tabanelli, Valentina, Griggio, Valentina, Stüssi, Georg, Calleri, Angelica, Pini, Katia, Cairoli, Roberto, Zenz, Thorsten, Signori, Alessio, Zucca, Emanuele, Rossi, Davide, Montillo, Marco, Tedeschi, A, Frustaci, A, Condoluci, A, Coscia, M, Chiarle, R, Zinzani, P, Motta, M, Gaidano, G, Quaresmini, G, Scarfò, L, Catania, G, Deodato, M, Jones, R, Tabanelli, V, Griggio, V, Stüssi, G, Calleri, A, Pini, K, Cairoli, R, Zenz, T, Signori, A, Zucca, E, Rossi, D, Montillo, M, Tedeschi, Alessandra, Frustaci, Anna Maria, Condoluci, Adalgisa, Coscia, Marta, Chiarle, Roberto, Zinzani, Pier Luigi, Motta, Marina, Gaidano, Gianluca, Quaresmini, Giulia, Scarfò, Lydia, Catania, Gioacchino, Deodato, Marina, Jones, Rebecca, Tabanelli, Valentina, Griggio, Valentina, Stüssi, Georg, Calleri, Angelica, Pini, Katia, Cairoli, Roberto, Zenz, Thorsten, Signori, Alessio, Zucca, Emanuele, Rossi, Davide, and Montillo, Marco
Published: 2024

2. Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan

Author: Rezoagli, E, Xin, Y, Signori, D, Sun, W, Gerard, S, Delucchi, K, Magliocca, A, Vitale, G, Giacomini, M, Mussoni, L, Montomoli, J, Subert, M, Ponti, A, Spadaro, S, Poli, G, Casola, F, Herrmann, J, Foti, G, Calfee, C, Laffey, J, Bellani, G, Cereda, M, Lorini, F, Bonaffini, P, Cazzaniga, M, Ottaviani, I, Tavola, M, Borgo, A, Ferraris, L, Serra, F, Gatti, S, Ippolito, D, Tamagnini, B, Gatti, M, Arlotti, M, Gamberini, E, Cavagna, E, Galbiati, G, De Ponti, D, Rezoagli E., Xin Y., Signori D., Sun W., Gerard S., Delucchi K. L., Magliocca A., Vitale G., Giacomini M., Mussoni L., Montomoli J., Subert M., Ponti A., Spadaro S., Poli G., Casola F., Herrmann J., Foti G., Calfee C. S., Laffey J., Bellani G., Cereda M., Lorini F. L., Bonaffini P., Cazzaniga M., Ottaviani I., Tavola M., Borgo A., Ferraris L., Serra F., Gatti S., Ippolito D., Tamagnini B., Gatti M., Arlotti M., Gamberini E., Cavagna E., Galbiati G., De Ponti D., Rezoagli, E, Xin, Y, Signori, D, Sun, W, Gerard, S, Delucchi, K, Magliocca, A, Vitale, G, Giacomini, M, Mussoni, L, Montomoli, J, Subert, M, Ponti, A, Spadaro, S, Poli, G, Casola, F, Herrmann, J, Foti, G, Calfee, C, Laffey, J, Bellani, G, Cereda, M, Lorini, F, Bonaffini, P, Cazzaniga, M, Ottaviani, I, Tavola, M, Borgo, A, Ferraris, L, Serra, F, Gatti, S, Ippolito, D, Tamagnini, B, Gatti, M, Arlotti, M, Gamberini, E, Cavagna, E, Galbiati, G, De Ponti, D, Rezoagli E., Xin Y., Signori D., Sun W., Gerard S., Delucchi K. L., Magliocca A., Vitale G., Giacomini M., Mussoni L., Montomoli J., Subert M., Ponti A., Spadaro S., Poli G., Casola F., Herrmann J., Foti G., Calfee C. S., Laffey J., Bellani G., Cereda M., Lorini F. L., Bonaffini P., Cazzaniga M., Ottaviani I., Tavola M., Borgo A., Ferraris L., Serra F., Gatti S., Ippolito D., Tamagnini B., Gatti M., Arlotti M., Gamberini E., Cavagna E., Galbiati G., and De Ponti D.
Abstract: Background: Automated analysis of lung computed tomography (CT) scans may help characterize subphenotypes of acute respiratory illness. We integrated lung CT features measured via deep learning with clinical and laboratory data in spontaneously breathing subjects to enhance the identification of COVID-19 subphenotypes. Methods: This is a multicenter observational cohort study in spontaneously breathing patients with COVID-19 respiratory failure exposed to early lung CT within 7 days of admission. We explored lung CT images using deep learning approaches to quantitative and qualitative analyses; latent class analysis (LCA) by using clinical, laboratory and lung CT variables; regional differences between subphenotypes following 3D spatial trajectories. Results: Complete datasets were available in 559 patients. LCA identified two subphenotypes (subphenotype 1 and 2). As compared with subphenotype 2 (n = 403), subphenotype 1 patients (n = 156) were older, had higher inflammatory biomarkers, and were more hypoxemic. Lungs in subphenotype 1 had a higher density gravitational gradient with a greater proportion of consolidated lungs as compared with subphenotype 2. In contrast, subphenotype 2 had a higher density submantellar–hilar gradient with a greater proportion of ground glass opacities as compared with subphenotype 1. Subphenotype 1 showed higher prevalence of comorbidities associated with endothelial dysfunction and higher 90-day mortality than subphenotype 2, even after adjustment for clinically meaningful variables. Conclusions: Integrating lung-CT data in a LCA allowed us to identify two subphenotypes of COVID-19, with different clinical trajectories. These exploratory findings suggest a role of automated imaging characterization guided by machine learning in subphenotyping patients with respiratory failure. Trial registration: ClinicalTrials.gov Identifier: NCT04395482. Registration date: 19/05/2020.
Published: 2024

3. Sponsor reputation and agency conflicts in SPACs

Author: Del Giudice, Alfonso, Signori, Andrea, Del Giudice A. (ORCID:0000-0003-3916-7521), Signori A. (ORCID:0000-0002-7502-5451), Del Giudice, Alfonso, Signori, Andrea, Del Giudice A. (ORCID:0000-0003-3916-7521), and Signori A. (ORCID:0000-0002-7502-5451)
Abstract: We investigate the agency conflict between sponsors and investors in Special Purpose Acquisition Companies (SPACs) and the role of sponsor reputation in such conflict. We find that the effect of reputation depends on whether sponsors are repeat or occasional players in financial markets. SPACs sponsored by private equity firms, who face reputational concerns due to frequent interactions with investors, conduct a more virtuous target selection process as they are less likely to merge but post-merger returns are significantly better. On the other hand, former executives of renowned companies who occasionally launch SPACs make deals more lucrative to themselves, with no benefits to investors.
Published: 2024

4. Informal carers' experiences with their children's care during hospitalization in Italy: child HCAHPS results from RN4CAST@IT-Ped cross-sectional study

Author: Dasso, Nicoletta, Catania, Gianluca, Zanini, Milko, Rossi, Silvia, Aleo, Giuseppe, Signori, Alessio, Scelsi, Silvia, Petralia, Paolo, Watson, Roger, Hayter, Mark, Sasso, Loredana, Bagnasco, Annamaria, Dasso, Nicoletta, Catania, Gianluca, Zanini, Milko, Rossi, Silvia, Aleo, Giuseppe, Signori, Alessio, Scelsi, Silvia, Petralia, Paolo, Watson, Roger, Hayter, Mark, Sasso, Loredana, and Bagnasco, Annamaria
Abstract: Purpose: To examine informal carers' experiences during their child's hospitalization and evaluate the associations with care received and care context. Design and methods: What is described in this article is only a part of the larger study, RN4CAST@IT-Ped, a multicenter cross-sectional study, with multi-level data collection through convenience sampling, the Child Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey was used to collect data from informal carers of pediatric patients, applying the “top box” approach. Results: Nine hospitals, 1472 nurses, and 635 children's parents were involved. A correlation was found between patient safety and satisfaction outcomes and nursing staff characteristics. Adequate workloads for nurses improved carers' assessment of their experience in the hospital. Conclusion: Adequate staffing management could significantly improve informal carers' satisfaction with the care provided to their children during hospitalization. Practice implications: Children's informal carers greatly value the care they receive in pediatric hospitals. Adequate workloads for nurses improve carers' overall evaluation of the care their children receive during hospitalization. Nursing management should consider improving these aspects to ensure high-quality care in children's hospitals.
Published: 2024

5. Phenotyping COVID-19 respiratory failure in spontaneously breathing patients with AI on lung CT-scan.

Author: Rezoagli, Emanuele, Rezoagli, Emanuele, Xin, Yi, Signori, Davide, Sun, Wenli, Gerard, Sarah, Delucchi, Kevin, Magliocca, Aurora, Vitale, Giovanni, Giacomini, Matteo, Mussoni, Linda, Montomoli, Jonathan, Subert, Matteo, Ponti, Alessandra, Spadaro, Savino, Poli, Giancarla, Casola, Francesco, Herrmann, Jacob, Foti, Giuseppe, Calfee, Carolyn, Laffey, John, Bellani, Giacomo, Cereda, Maurizio, Rezoagli, Emanuele, Rezoagli, Emanuele, Xin, Yi, Signori, Davide, Sun, Wenli, Gerard, Sarah, Delucchi, Kevin, Magliocca, Aurora, Vitale, Giovanni, Giacomini, Matteo, Mussoni, Linda, Montomoli, Jonathan, Subert, Matteo, Ponti, Alessandra, Spadaro, Savino, Poli, Giancarla, Casola, Francesco, Herrmann, Jacob, Foti, Giuseppe, Calfee, Carolyn, Laffey, John, Bellani, Giacomo, and Cereda, Maurizio
Abstract: BACKGROUND: Automated analysis of lung computed tomography (CT) scans may help characterize subphenotypes of acute respiratory illness. We integrated lung CT features measured via deep learning with clinical and laboratory data in spontaneously breathing subjects to enhance the identification of COVID-19 subphenotypes. METHODS: This is a multicenter observational cohort study in spontaneously breathing patients with COVID-19 respiratory failure exposed to early lung CT within 7 days of admission. We explored lung CT images using deep learning approaches to quantitative and qualitative analyses; latent class analysis (LCA) by using clinical, laboratory and lung CT variables; regional differences between subphenotypes following 3D spatial trajectories. RESULTS: Complete datasets were available in 559 patients. LCA identified two subphenotypes (subphenotype 1 and 2). As compared with subphenotype 2 (n = 403), subphenotype 1 patients (n = 156) were older, had higher inflammatory biomarkers, and were more hypoxemic. Lungs in subphenotype 1 had a higher density gravitational gradient with a greater proportion of consolidated lungs as compared with subphenotype 2. In contrast, subphenotype 2 had a higher density submantellar-hilar gradient with a greater proportion of ground glass opacities as compared with subphenotype 1. Subphenotype 1 showed higher prevalence of comorbidities associated with endothelial dysfunction and higher 90-day mortality than subphenotype 2, even after adjustment for clinically meaningful variables. CONCLUSIONS: Integrating lung-CT data in a LCA allowed us to identify two subphenotypes of COVID-19, with different clinical trajectories. These exploratory findings suggest a role of automated imaging characterization guided by machine learning in subphenotyping patients with respiratory failure. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04395482. Registration date: 19/05/2020.
Published: 2024

6. Quantitative assessment of tip-toe behavior in individuals with autism spectrum disorder and intellectual disability: A cross-sectional study

Author: Valagussa, G, Purpura, G, Balatti, V, Trentin, L, Signori, A, Grossi, E, Valagussa, G, Purpura, G, Balatti, V, Trentin, L, Signori, A, and Grossi, E
Abstract: The term “toe walking” describes walking on the toes with a lack of heel strike upon initiation of the stance phase of gait. In individuals with autism spectrum disorder (ASD), this phenomenon, or “tip-toe behavior” (TTB), can be present in a substantial proportion of subjects even during standing. In this study, we investigated TTB in 50 persons with ASD (age range 4–26 years). We evaluated TTB through an observational/report-based assessment protocol. Subsequently, we employed a new structured video-based coding protocol based on standardized video recordings, focusing on static and dynamic conditions. Finally, the findings of the two protocols were compared. Twenty-four subjects with TTB were identified and classified according to three functional groups: TTB1, present only during running (6 subjects); TTB2, present during walking and running (11 subjects); and TTB3, present during standing, walking, and running (7 subjects). Moreover, we found that TTB3 subjects exhibited a significantly higher quantity of TTB compared with subjects in the TTB1 and TTB2 groups during both standing and walking tests. Additionally, a high quantity of TTB in the static test was found to be related to a high quantity of TTB in the dynamic test. Variables such as age, autism severity, intellectual disability, and gender were not significantly associated with the mean percent of TTB both in static and dynamic tests in multivariate analysis. This structured video-based coding approach appears feasible and useful for assessing TTB in individuals with ASD and it has the potential to provide insights into TTB trajectories and aid in designing possible interventions.
Published: 2024

7. NEDA-3 achievement in early highly active relapsing remitting multiple sclerosis patients treated with Ocrelizumab or Natalizumab

Author: Signoriello, Elisabetta, Signori, Alessio, Lus, Giacomo, Romano, Giuseppe, Marfia, Girolama Alessandra, Landi, Doriana, Napoli, Francesca, D' Amico, Emanuele, Zanghí, Aurora, Di Filippo, Paola Sofia, Caliendo, Daniele, Carotenuto, Antonio, Spiezia, Antonio Luca, Fantozzi, Roberta, Centonze, Diego, Lucchini, Matteo, Mirabella, Massimiliano, Cocco, Eleonora, Frau, Jessica, Maniscalco, Giorgia Teresa, Di Battista, Maria Elena, Foschi, Matteo, Surcinelli, Andrea, Bonavita, Simona, Abbadessa, Gianmarco, Pasquali, Livia, Di Gregorio, Maria, Ferrò, Maria Teresa, Sormani, Maria Pia, Schiavetti, Irene, Lucchini, Matteo (ORCID:0000-0002-0447-2297), Mirabella, Massimiliano (ORCID:0000-0002-7783-114X), Signoriello, Elisabetta, Signori, Alessio, Lus, Giacomo, Romano, Giuseppe, Marfia, Girolama Alessandra, Landi, Doriana, Napoli, Francesca, D' Amico, Emanuele, Zanghí, Aurora, Di Filippo, Paola Sofia, Caliendo, Daniele, Carotenuto, Antonio, Spiezia, Antonio Luca, Fantozzi, Roberta, Centonze, Diego, Lucchini, Matteo, Mirabella, Massimiliano, Cocco, Eleonora, Frau, Jessica, Maniscalco, Giorgia Teresa, Di Battista, Maria Elena, Foschi, Matteo, Surcinelli, Andrea, Bonavita, Simona, Abbadessa, Gianmarco, Pasquali, Livia, Di Gregorio, Maria, Ferrò, Maria Teresa, Sormani, Maria Pia, Schiavetti, Irene, Lucchini, Matteo (ORCID:0000-0002-0447-2297), and Mirabella, Massimiliano (ORCID:0000-0002-7783-114X)
Abstract: Background: in the early stages of Multiple Sclerosis (MS), initiating high-efficacy disease-modifying therapy (HE DMTs) may represent an optimal strategy for delaying neurological damage and long-term disease progression, especially in highly active MS patients (HAMS). Natalizumab (NAT) and Ocrelizumab (OCR) are recognized as HE DMTs with significant anti-inflammatory effects. This study investigates NEDA-3 achievement in treatment-naïve HAMS patients receiving NAT or OCR over three years. Methods: we retrospectively enrolled treatment-naïve HAMS patients undergoing NAT or OCR, collecting demographic, clinical, and instrumental data before and after treatment initiation to compare with propensity score analysis disease activity, time to disability worsening, and NEDA-3 achievement. Results: we recruited 281 HAMS patients with a mean age of 32.7 years (SD 10.33), treated with NAT (157) or OCR (124). After three years, the Kaplan-Meier probability of achieving NEDA-3 was 66.0 % (95 % CI: 57.3 % - 76.0 %) with OCR and 68.2 % (95 % CI: 59.9 % - 77.7 %) with NAT without significant differences between the two groups (p = 0.27) DISCUSSION AND CONCLUSION: starting HE DMT with monoclonal antibodies for HAMS could achieve NEDA-3 in a high percentage of patients without differences between NAT or OCR.
Published: 2024

8. Effect of music and time of day on cardiorespiratory responses during aerobic exercise

Author: Vukaj, X., Signori, C., Grignani, L., Figini, A., Baratti, M., Cantarelli, D., Ghirardi, P., Gallazzi, M., Andriolo, G., Bruseghini, Paolo, Annoni, I., Bertozzi, F., Galvani, Christel, X. Vukaj, C. Signori, L. Grignani, A. Figini, M. Baratti, D. Cantarelli, P. Ghirardi, M. Gallazzi, G. Andriolo, P. Bruseghini (ORCID:0000-0003-0285-5443), I. Annoni, F. Bertozzi, C. Galvani (ORCID:0000-0002-0126-6033), Vukaj, X., Signori, C., Grignani, L., Figini, A., Baratti, M., Cantarelli, D., Ghirardi, P., Gallazzi, M., Andriolo, G., Bruseghini, Paolo, Annoni, I., Bertozzi, F., Galvani, Christel, X. Vukaj, C. Signori, L. Grignani, A. Figini, M. Baratti, D. Cantarelli, P. Ghirardi, M. Gallazzi, G. Andriolo, P. Bruseghini (ORCID:0000-0003-0285-5443), I. Annoni, F. Bertozzi, and C. Galvani (ORCID:0000-0002-0126-6033)
Abstract: Purpose: For a proper exercise (EX) prescription, it is necessary to consider the individual needs, such as the effect of regular training at a specific time of day1 or of listening to music while exercising2. The evidence regarding the combined effect of music at different times of the day do not seem to be sufficiently investigated. The aim of the present study is to examine the effects induced by music listened during the aerobic exercise on oxygen consumption (mV_O2), in males and females, in two different intensity domains (moderate and vigorous), at two different times of day (morning and evening). Methods: Forty university students were recruited: 20 males and 20 females (age 22.7 ± 2.6 yrs; BMI 21.8 ± 2.5 kg m-2; mV_O2max 39.7 ± 7.9 mL kg-1 min-1). All subjects performed 4 training sessions at two different times of day, with and without self- selected motivational music3: 2 in the morning from 8:30 to 9:30 am (MO ? M, MO-M) and 2 in the evening from 17:30 to 18:30 pm (EV ? M, EV-M). Each training session included 6 min of cycling at constant load corresponding to 60% (MOD) and 90% (VIG) of mV_O2max, interspersed with 10 min of recovery. The mV_O2 was continuously monitored, obtaining data averaged every 30 s (Fitmate, Cosmed, Italy). Results: At the end of MOD EX, females, regardless of listening to music, obtained lower mV_O2 in the evening (p = 0.03) (EV ? M 1192.0 ± 236.6 and EV-M 1203.4 ± 252.5 vs MO ? M 1232.1 ± 284.3 and MO-M 1216.5 ± 249.5 mL min-1, respectively); males attained lower VO2 while listening to music only in the evening (p = 0.04) (EV ? M 1876.7 ± 283.5 and EV-M 1915,7 ± 313,4 vs MO ? M 1896.8 ± 302.7 and MO-M 1867.7±316.7 mL min-1, respectively). At the end of VIG EX, regardless of listening to music, only females showed lower mV_O2 in the evening (p = 0.02) (EV ? M 1946.2 ± 390.6 and EV-M 1980.7 ± 464.4 vs MO ? M 1985.9 ± 453.3 and MO-M 1985.7±422.8 mL min-1, respectively). Conclusions: Regardless of listening to music, during both MOD
Published: 2023

9. Regentinnen und andere Stellvertreterfiguren: zur Einführung

Author: Signori, Gabriela, Zey, Claudia, Signori, G ( Gabriela ), Zey, C ( Claudia ), Signori, Gabriela, Zey, Claudia, Signori, G ( Gabriela ), and Zey, C ( Claudia )
Published: 2023

10. The exit choices of European private firms: A dynamic empirical analysis

Author: Chemmanur, Thomas J., Signori, Andrea, Vismara, Silvio, Andrea Signori (ORCID:0000-0002-7502-5451), Chemmanur, Thomas J., Signori, Andrea, Vismara, Silvio, and Andrea Signori (ORCID:0000-0002-7502-5451)
Abstract: Using a European private firm sample, we conduct a dynamic empirical analysis of private firm exit choice, previously modeled as a one-time IPO versus acquisition decision. Going public may yield firms a valuation premium (over a direct acquisition) through a post-IPO acquisition, but may also involve possible delisting at a valuation discount. We explicitly account for these dynamic considerations and show that such considerations alter firms’ initial exit trade-off: firms that anticipate a higher post-IPO acquisition probability are more likely to go public initially; those that anticipate a higher post-IPO delisting probability are more likely to choose a direct acquisition.
Published: 2023

11. A Novel Mask with Selective Ports for Inflow and Outflow Reduces CO2 Rebreathing during Non-Invasive Ventilation: A Physiological Study in Healthy Volunteers

Author: Rezoagli, E, Signori, D, Grassi, A, Rabboni, F, Lucchini, A, Bellani, G, Foti, G, Rezoagli, Emanuele, Signori, Davide, Grassi, Alice, Rabboni, Francesca, Lucchini, Alberto, Bellani, Giacomo, Foti, Giuseppe, Rezoagli, E, Signori, D, Grassi, A, Rabboni, F, Lucchini, A, Bellani, G, Foti, G, Rezoagli, Emanuele, Signori, Davide, Grassi, Alice, Rabboni, Francesca, Lucchini, Alberto, Bellani, Giacomo, and Foti, Giuseppe
Abstract: Background: CO2 rebreathing is one of the risks associated with noninvasive ventilation (NIV), possibly contributing to failure. In a bench study, we showed that a novel mask design, with separate limbs for inflow and outflow gases, significantly reduced CO2 rebreathing in different ventilation settings. Objectives: The study aimed to test whether a new mask design could 1) reduce CO2 rebreathing in healthy volunteers during NIV (phase 1) and 2) reduce minute ventilation (phase 2). Materials and Methods: Healthy volunteers were randomly assigned to NIV using two masks in a crossover design: a traditional single-limb mask for inflow and outflow gases and a mask with two separated limbs. In phase 1, six ventilation settings were tested for each mask: CPAP (PEEP 5 cmH2O) and pressure support ventilation (PSV, PS Level 5 cmH2O) using a mechanical ventilator with a bias flow of 8 or 20 L/min; free-flow CPAP (PEEP 5 cmH2O) with 60 or 90 L/min of gas flow. A nasal cannula was inserted in one nostril of the volunteers and connected to a CO2 gas analyzer to measure CO2 during the respiratory cycle. In phase 2, volunteers underwent a prolonged time of ventilation in CPAP 90 L/min and PSV with 20 L/min of bias flow. During free-flow CPAP, electrical impedance tomography was used to record the change in impedance during tidal breathing and then estimate tidal volume. Results: Ten healthy adults were enrolled in phase 1, and 8 volunteers in phase 2. CO2 during inspiration was significantly lower in each setting with the two-limb versus the one-limb mask (p < 0.001). The maximum CO2 reduction was observed in the continuous-flow CPAP settings. EtCO2 was lower with the two-limb mask compared to the one-limb mask (p < 0.001). However, no difference in minute ventilation was observed between the two masks. Conclusion: The new mask design with two ports for inhaled and exhaled gases reduced the amount of CO2 rebreathing in all tested ventilation settings. The CO2 rebreathing red
Published: 2023

12. Safety and Effectiveness of Intensive Treatments Administered Outside the Intensive Care Unit to Hematological Critically Ill Patients: An Intensive Care without Walls Trial

Author: Vergnano, B, Signori, D, Benini, A, Calcinati, S, Bettini, F, Verga, L, Borin, L, Cavalca, F, Gambacorti-Passerini, C, Bellani, G, Foti, G, Vergnano B., Signori D., Benini A., Calcinati S., Bettini F., Verga L., Borin L. M., Cavalca F., Gambacorti-Passerini C., Bellani G., Foti G., Vergnano, B, Signori, D, Benini, A, Calcinati, S, Bettini, F, Verga, L, Borin, L, Cavalca, F, Gambacorti-Passerini, C, Bellani, G, Foti, G, Vergnano B., Signori D., Benini A., Calcinati S., Bettini F., Verga L., Borin L. M., Cavalca F., Gambacorti-Passerini C., Bellani G., and Foti G.
Abstract: Historically, the admission of hematological patients in the ICU shortly after the start of a critical illness is associated with better survival rates. Early intensive interventions administered by MET could play a role in the management of hematological critically ill patients, eventually reducing the ICU admission rate. In this retrospective and monocentric study, we evaluate the safety and effectiveness of intensive treatments administered by the MET in a medical ward frame. The administered interventions were mainly helmet CPAP and pharmacological cardiovascular support. Frequent reassessment by the MET at least every 8 to 12 h was guaranteed. We analyzed data from 133 hematological patients who required MET intervention. In-hospital mortality was 38%; mortality does not increase in patients not immediately transferred to the ICU. Only three patients died without a former admission to the ICU; in these cases, mortality was not related to the acute illness. Moreover, 37% of patients overcame the critical episode in the hematological ward. Higher SOFA and MEWS scores were associated with a worse survival rate, while neutropenia and pharmacological immunosuppression were not. The MET approach seems to be safe and effective. SOFA and MEWS were confirmed to be effective tools for prognostication.
Published: 2023

13. Spin of information and inconsistency between abstract and full text in RCTs investigating upper limb rehabilitation after stroke: An overview study

Author: Tosatto, D, Bonacina, D, Signori, A, Pellicciari, L, Cecchi, F, Cornaggia, C, Piscitelli, D, Tosatto, Diego, Bonacina, Daniele, Signori, Alessio, Pellicciari, Leonardo, Cecchi, Francesca, Cornaggia, Cesare Maria, Piscitelli, Daniele, Tosatto, D, Bonacina, D, Signori, A, Pellicciari, L, Cecchi, F, Cornaggia, C, Piscitelli, D, Tosatto, Diego, Bonacina, Daniele, Signori, Alessio, Pellicciari, Leonardo, Cecchi, Francesca, Cornaggia, Cesare Maria, and Piscitelli, Daniele
Abstract: Background: Researchers may be tempted to favorably distort the interpretation of their findings when reporting the abstract (i.e., spin). Spin bias overemphasizes the beneficial effects of the intervention compared with the results shown in the full text. Objective: To assess the occurrence of spin bias and incompleteness in reporting abstracts in post-stroke upper limb (UL) rehabilitation randomized clinical trials (RCTs). Methods: A sample of 120 post-stroke UL rehabilitation RCTs (indexed in PEDro database), published in English between 2012 and 2020, was included. The completeness of reporting and spin were assessed using the Consolidated Standards of Reporting Trials for Abstracts (CONSORT-A) and the spin checklist. The relationship between CONSORT-A and spin checklist scores with RCT and journal characteristics was assessed. Results: CONSORT-A and spin checklist scored 5.3±2.4 (max 15-points, higher scores indicating better reporting) and 5.5±2.0 (max 7-points, higher scores indicating presence of spin), respectively; Significant differences were detected between abstract and full-text scores in the CONSORT-A checklist (p < 0.01) and the spin checklist (p < 0.01). Items of the CONSORT-A checklist in the abstracts and full text showed a fair agreement (k = 0.31), while a moderate agreement (k = 0.59) for the spin checklist was detected. Completeness of abstract was associated (R2 = 0.46) with journal Impact Factor (p < 0.01), CONSORT Guideline endorsement (p = 0.04), and abstract word number (p = 0.02). A lower spin was associated with a higher journal Impact Factor (p = 0.01) and CONSORT Guideline endorsement (p = 0.01). Conclusions: Post-stroke UL rehabilitation RCTs abstracts were largely incomplete showing spin. Authors, reviewers, publishers, and stakeholders should be aware of this phenomenon. Publishers should consider allowing more words in abstracts to improve the completeness of reporting abstracts. Although we have investigated only stroke
Published: 2022

14. Performance, investment, and financing patterns of family firms after going public

Author: Croci, Ettore, Rigamonti, Silvia, Signori, Andrea, Ettore Croci (ORCID:0000-0002-1221-2102), Silvia Rigamonti (ORCID:0000-0002-5522-8366), Andrea Signori (ORCID:0000-0002-7502-5451), Croci, Ettore, Rigamonti, Silvia, Signori, Andrea, Ettore Croci (ORCID:0000-0002-1221-2102), Silvia Rigamonti (ORCID:0000-0002-5522-8366), and Andrea Signori (ORCID:0000-0002-7502-5451)
Abstract: Research Question/Issue: This study investigates the performance, investment, and financing patterns of family firms after they go public. Research Findings/Insights: Despite the common claim that most initial public offerings (IPOs) are motivated by growth considerations, we find that the operating performance of family firms declines after going public relative to non-family issuers and comparable private firms. This effect is long-lasting and not due to earnings management before the IPO. We also document that family firms do not differ from other firms in terms of investment activities, but they experience a smaller decrease in leverage. Theoretical/Academic Implications: The contributions of this study are threefold. First, it delves into the incentives of controlling families when facing the IPO decision. Second, while financial investors' ability to effectively time IPO decisions has been previously documented, this study shows that families, despite peculiar incentives, take their firms public before a performance decline. Third, it examines the behavior of family firms concerning the usage of IPO proceeds. Practitioner/Policy Implications: Families accept diluting their stake in an IPO when they know that firm performance is about to deteriorate. This increases the relative attractiveness of the non-pecuniary benefits of control, most of which remain with the family, over financial wealth, whose future value is expected to decrease.
Published: 2022

15. Delirium and Clusters of Older Patients Affected by Multimorbidity in Acute Hospitals

Author: Monacelli, F, Signori, A, Marengoni, A, Di Santo, S, Rossi, E, Valsecchi, M, Morandi, A, Bellelli, G, Monacelli, Fiammetta, Signori, Alessio, Marengoni, Alessandra, Di Santo, Simona, Rossi, Emanuela, Valsecchi, Maria Grazia, Morandi, Alessandro, Bellelli, Giuseppe, Monacelli, F, Signori, A, Marengoni, A, Di Santo, S, Rossi, E, Valsecchi, M, Morandi, A, Bellelli, G, Monacelli, Fiammetta, Signori, Alessio, Marengoni, Alessandra, Di Santo, Simona, Rossi, Emanuela, Valsecchi, Maria Grazia, Morandi, Alessandro, and Bellelli, Giuseppe
Abstract: Objectives: Delirium is commonly seen in older adults with multimorbidity, during a hospitalization, resulting from the interplay between predisposing factors such as advanced age, frailty, and dementia, and a series of precipitating factors. The association between delirium and specific multimorbidity is largely unexplored so far although of potential key relevance for targeted interventions. The aim of the study was to check for a potential association of multimorbidity with delirium in a large cohort of older patients hospitalized for an acute medical or surgical condition. Design: This is a cross-sectional study nested in the 2017 Delirium Day project. Setting and Participants: The study includes 1829 hospitalized patients (age: 81.8, SD: 5.5). Of them, 419 (22.9%) had delirium. Methods: Sociodemographic and medical history were collected. The 4AT was used to assess the presence of delirium. The Charlson Comorbidity index was used to assess multimorbidity. Results: The results identified neurosensorial multimorbidity as the most prevalent, including patients with dementia, cerebrovascular diseases, and sensory impairments. In light of the highest co-occurrence of 3 neurosensorial chronic conditions, we could hypothesize that a baseline altered brain functional and neural connectivity might determine the vulnerability signature for incipient overall system disruption in presence of acute insults. Conclusions and Implications: Eventually, our findings moved a step forward in supporting the key importance of routine screening for sensory impairments and cognitive status of older patients for the highest risk of in-hospital delirium. In fact, preventive interventions could be particularly relevant and effective in preventing delirium in such vulnerable populations and might help refining this early diagnosis.
Published: 2022

16. Basin-wide variation in tree hydraulic safety margins predicts the carbon balance of Amazon forests

Author: Tavares, Julia, Oliveira, Rafael S., Mencuccini, Maurizio, Signori-Mueller, Caroline, Pereira, Luciano, Diniz, Francisco Carvalho, Gilpin, Martin, Zevallos, Manuel Marca J., Yupayccana, Carlos Salas A., Acosta, Martin, Mullisaca, Flor Perez, Barros, Fernanda de V., Bittencourt, Paulo, Jancoski, Halina, Scalon, Marina Correa, Marimon, Beatriz S., Menor, Imma Oliveras, Marimon Jr, Ben Hur, Fancourt, Max, Chambers-Ostler, Alexander, Esquivel-Muelbert, Adriane, Rowland, Lucy, Meir, Patrick, da Costa, Antonio Carlos Lola, Nina, Alex, Sanchez, Jesus M. B., Tintaya, Jose S., Chino, Rudi S. C., Baca, Jean, Fernandes, Leticia, Cumapa, Edwin R. M., Santos, Joao Antonio R., Teixeira, Renata, Tello, Ligia, Ugarteche, Maira T. M., Cuellar, Gina A., Martinez, Franklin, Araujo-Murakami, Alejandro, Almeida, Everton, da Cruz, Wesley Jonatar Alves, Pasquel, Jhon del Aguila, Aragao, Luis, Baker, Timothy R., de Camargo, Plinio Barbosa, Brienen, Roel, Castro, Wendeson, Ribeiro, Sabina Cerruto, de Souza, Fernanda Coelho, Cosio, Eric G., Cardozo, Nallaret Davila, Silva, Richarlly da Costa, Disney, Mathias, Espejo, Javier Silva, Feldpausch, Ted R., Ferreira, Leandro, Giacomin, Leandro, Higuchi, Niro, Hirota, Marina, Honorio, Euridice, Huasco, Walter Huaraca, Lewis, Simon, Llampazo, Gerardo Flores, Malhi, Yadvinder, Mendoza, Abel Monteagudo, Morandi, Paulo, Moscoso, Victor Chama, Muscarella, Robert, Penha, Deliane, Rocha, Mayda Cecilia, Rodrigues, Gleicy, Ruschel, Ademir R., Salinas, Norma, Schlickmann, Monique, Silveira, Marcos, Talbot, Joey, Vasquez, Rodolfo, Vedovato, Laura, Vieira, Simone Aparecida, Phillips, Oliver L., Gloor, Emanuel, Galbraith, David R., Tavares, Julia, Oliveira, Rafael S., Mencuccini, Maurizio, Signori-Mueller, Caroline, Pereira, Luciano, Diniz, Francisco Carvalho, Gilpin, Martin, Zevallos, Manuel Marca J., Yupayccana, Carlos Salas A., Acosta, Martin, Mullisaca, Flor Perez, Barros, Fernanda de V., Bittencourt, Paulo, Jancoski, Halina, Scalon, Marina Correa, Marimon, Beatriz S., Menor, Imma Oliveras, Marimon Jr, Ben Hur, Fancourt, Max, Chambers-Ostler, Alexander, Esquivel-Muelbert, Adriane, Rowland, Lucy, Meir, Patrick, da Costa, Antonio Carlos Lola, Nina, Alex, Sanchez, Jesus M. B., Tintaya, Jose S., Chino, Rudi S. C., Baca, Jean, Fernandes, Leticia, Cumapa, Edwin R. M., Santos, Joao Antonio R., Teixeira, Renata, Tello, Ligia, Ugarteche, Maira T. M., Cuellar, Gina A., Martinez, Franklin, Araujo-Murakami, Alejandro, Almeida, Everton, da Cruz, Wesley Jonatar Alves, Pasquel, Jhon del Aguila, Aragao, Luis, Baker, Timothy R., de Camargo, Plinio Barbosa, Brienen, Roel, Castro, Wendeson, Ribeiro, Sabina Cerruto, de Souza, Fernanda Coelho, Cosio, Eric G., Cardozo, Nallaret Davila, Silva, Richarlly da Costa, Disney, Mathias, Espejo, Javier Silva, Feldpausch, Ted R., Ferreira, Leandro, Giacomin, Leandro, Higuchi, Niro, Hirota, Marina, Honorio, Euridice, Huasco, Walter Huaraca, Lewis, Simon, Llampazo, Gerardo Flores, Malhi, Yadvinder, Mendoza, Abel Monteagudo, Morandi, Paulo, Moscoso, Victor Chama, Muscarella, Robert, Penha, Deliane, Rocha, Mayda Cecilia, Rodrigues, Gleicy, Ruschel, Ademir R., Salinas, Norma, Schlickmann, Monique, Silveira, Marcos, Talbot, Joey, Vasquez, Rodolfo, Vedovato, Laura, Vieira, Simone Aparecida, Phillips, Oliver L., Gloor, Emanuel, and Galbraith, David R.
Abstract: Tropical forests face increasing climate risk(1,2), yet our ability to predict their response to climate change is limited by poor understanding of their resistance to water stress. Although xylem embolism resistance thresholds (for example, ?(50)) and hydraulic safety margins (for example, HSM50) are important predictors of drought-induced mortality risk(3-5), little is known about how these vary across Earth's largest tropical forest. Here, we present a pan-Amazon, fully standardized hydraulic traits dataset and use it to assess regional variation in drought sensitivity and hydraulic trait ability to predict species distributions and long-term forest biomass accumulation. Parameters ?(50) and HSM50 vary markedly across the Amazon and are related to average long-term rainfall characteristics. Both ?(50) and HSM50 influence the biogeographical distribution of Amazon tree species. However, HSM50 was the only significant predictor of observed decadal-scale changes in forest biomass. Old-growth forests with wide HSM50 are gaining more biomass than are low HSM(50 )forests. We propose that this may be associated with a growth-mortality trade-off whereby trees in forests consisting of fast-growing species take greater hydraulic risks and face greater mortality risk. Moreover, in regions of more pronounced climatic change, we find evidence that forests are losing biomass, suggesting that species in these regions may be operating beyond their hydraulic limits. Continued climate change is likely to further reduce HSM50 in the Amazon(6,7), with strong implications for the Amazon carbon sink.
Published: 2023
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17. The case for an EIC Theory Alliance: Theoretical Challenges of the EIC

Author: Abir, Raktim, Akushevich, Igor, Altinoluk, Tolga, Anderle, Daniele Paolo, Aslan, Fatma P., Bacchetta, Alessandro, Balantekin, Baha, Barata, Joao, Battaglieri, Marco, Bertulani, Carlos A., Beuf, Guillaume, Bissolotti, Chiara, Boer, Daniël, Boglione, M., Boughezal, Radja, Braaten, Eric, Brambilla, Nora, Braun, Vladimir, Byer, Duane, Celiberto, Francesco Giovanni, Chien, Yang-Ting, Cloët, Ian C., Constantinou, Martha, Cosyn, Wim, Courtoy, Aurore, Czajka, Alexander, D'Alesio, Umberto, Bozzi, Giuseppe, Danilkin, Igor, Das, Debasish, de Florian, Daniel, Delgado, Andrea, de Melo, J. P. B. C., Detmold, William, Döring, Michael, Dumitru, Adrian, Echevarria, Miguel G., Edwards, Robert, Eichmann, Gernot, El-Bennich, Bruno, Engelhardt, Michael, Fernandez-Ramirez, Cesar, Fischer, Christian, Fox, Geofrey, Freese, Adam, Gamberg, Leonard, Garzelli, Maria Vittoria, Giacosa, Francesco, da Silveira, Gustavo Gil, Glazier, Derek, Goncalves, Victor P., Grossberndt, Silas, Guo, Feng-Kun, Gupta, Rajan, Hatta, Yoshitaka, Hentschinski, Martin, Blin, Astrid Hiller, Hobbs, Timothy, Ilyichev, Alexander, Jalilian-Marian, Jamal, Ji, Chueng-Ryong, Jia, Shuo, Kang, Zhong-Bo, Karki, Bishnu, Ke, Weiyao, Khachatryan, Vladimir, Kharzeev, Dmitri, Klein, Spencer R., Korepin, Vladimir, Kovchegov, Yuri, Kriesten, Brandon, Kumano, Shunzo, Lai, Wai Kin, Lebed, Richard, Lee, Christopher, Lee, Kyle, Li, Hai Tao, Liao, Jifeng, Lin, Huey-Wen, Liu, Keh-Fei, Liuti, Simonetta, Lorcé, Cédric, Machado, Magno V. T., Mantysaari, Heikki, Mathieu, Vincent, Mathur, Nilmani, Mehtar-Tani, Yacine, Melnitchouk, Wally, Mereghetti, Emanuele, Metz, Andreas, Michel, Johannes K. L., Miller, Gerald, Mkrtchyan, Hamlet, Mukherjee, Asmita, Mukherjee, Swagato, Mulders, Piet, Munier, Stéphane, Murgia, Francesco, Nadolsky, P. M., Negele, John W, Neill, Duff, Nemchik, Jan, Nocera, E., Okorokov, Vitalii, Olness, Fredrick, Pasquini, Barbara, Peng, Chao, Petreczky, Peter, Petriello, Frank, Pilloni, Alessandro, Pire, Bernard, Pisano, Cristian, Pitonyak, Daniel, Praszalowicz, Michal, Prokudin, Alexei, Qiu, Jianwei, Radici, Marco, Raya, Khépani, Ringer, Felix, West, Jennifer Rittenhouse, Rodas, Arkaitz, Rodini, Simone, Rojo, Juan, Salazar, Farid, Santopinto, Elena, Sargsian, Misak, Sato, Nobuo, Schenke, Bjoern, Schindler, Stella, Schnell, Gunar, Schweitzer, Peter, Scimemi, Ignazio, Segovia, Jorge, Semenov-Tian-Shansky, Kirill, Shanahan, Phiala, Shao, Ding-Yu, Sievert, Matt, Signori, Andrea, Singh, Rajeev, Skokov, Vladi, Song, Qin-Tao, Srednyak, Stanislav, Stewart, Iain W., Sufian, Raza Sabbir, Swanson, Eric, Syritsyn, Sergey, Szczepaniak, Adam, Sznajder, Pawel, Tandogan, Asli, Tawabutr, Yossathorn, Tawfik, A., Terry, John, Toll, Tobias, Tomalak, Oleksandr, Twagirayezu, Fidele, Venugopalan, Raju, Vitev, Ivan, Vladimirov, Alexey, Vogelsang, Werner, Vogt, Ramona, Vujanovic, Gojko, Waalewijn, Wouter, Wang, Xiang-Peng, Xiao, Bo-Wen, Xing, Hongxi, Yang, Yi-Bo, Yao, Xiaojun, Yuan, Feng, Zhao, Yong, Zurita, Pia, Abir, Raktim, Akushevich, Igor, Altinoluk, Tolga, Anderle, Daniele Paolo, Aslan, Fatma P., Bacchetta, Alessandro, Balantekin, Baha, Barata, Joao, Battaglieri, Marco, Bertulani, Carlos A., Beuf, Guillaume, Bissolotti, Chiara, Boer, Daniël, Boglione, M., Boughezal, Radja, Braaten, Eric, Brambilla, Nora, Braun, Vladimir, Byer, Duane, Celiberto, Francesco Giovanni, Chien, Yang-Ting, Cloët, Ian C., Constantinou, Martha, Cosyn, Wim, Courtoy, Aurore, Czajka, Alexander, D'Alesio, Umberto, Bozzi, Giuseppe, Danilkin, Igor, Das, Debasish, de Florian, Daniel, Delgado, Andrea, de Melo, J. P. B. C., Detmold, William, Döring, Michael, Dumitru, Adrian, Echevarria, Miguel G., Edwards, Robert, Eichmann, Gernot, El-Bennich, Bruno, Engelhardt, Michael, Fernandez-Ramirez, Cesar, Fischer, Christian, Fox, Geofrey, Freese, Adam, Gamberg, Leonard, Garzelli, Maria Vittoria, Giacosa, Francesco, da Silveira, Gustavo Gil, Glazier, Derek, Goncalves, Victor P., Grossberndt, Silas, Guo, Feng-Kun, Gupta, Rajan, Hatta, Yoshitaka, Hentschinski, Martin, Blin, Astrid Hiller, Hobbs, Timothy, Ilyichev, Alexander, Jalilian-Marian, Jamal, Ji, Chueng-Ryong, Jia, Shuo, Kang, Zhong-Bo, Karki, Bishnu, Ke, Weiyao, Khachatryan, Vladimir, Kharzeev, Dmitri, Klein, Spencer R., Korepin, Vladimir, Kovchegov, Yuri, Kriesten, Brandon, Kumano, Shunzo, Lai, Wai Kin, Lebed, Richard, Lee, Christopher, Lee, Kyle, Li, Hai Tao, Liao, Jifeng, Lin, Huey-Wen, Liu, Keh-Fei, Liuti, Simonetta, Lorcé, Cédric, Machado, Magno V. T., Mantysaari, Heikki, Mathieu, Vincent, Mathur, Nilmani, Mehtar-Tani, Yacine, Melnitchouk, Wally, Mereghetti, Emanuele, Metz, Andreas, Michel, Johannes K. L., Miller, Gerald, Mkrtchyan, Hamlet, Mukherjee, Asmita, Mukherjee, Swagato, Mulders, Piet, Munier, Stéphane, Murgia, Francesco, Nadolsky, P. M., Negele, John W, Neill, Duff, Nemchik, Jan, Nocera, E., Okorokov, Vitalii, Olness, Fredrick, Pasquini, Barbara, Peng, Chao, Petreczky, Peter, Petriello, Frank, Pilloni, Alessandro, Pire, Bernard, Pisano, Cristian, Pitonyak, Daniel, Praszalowicz, Michal, Prokudin, Alexei, Qiu, Jianwei, Radici, Marco, Raya, Khépani, Ringer, Felix, West, Jennifer Rittenhouse, Rodas, Arkaitz, Rodini, Simone, Rojo, Juan, Salazar, Farid, Santopinto, Elena, Sargsian, Misak, Sato, Nobuo, Schenke, Bjoern, Schindler, Stella, Schnell, Gunar, Schweitzer, Peter, Scimemi, Ignazio, Segovia, Jorge, Semenov-Tian-Shansky, Kirill, Shanahan, Phiala, Shao, Ding-Yu, Sievert, Matt, Signori, Andrea, Singh, Rajeev, Skokov, Vladi, Song, Qin-Tao, Srednyak, Stanislav, Stewart, Iain W., Sufian, Raza Sabbir, Swanson, Eric, Syritsyn, Sergey, Szczepaniak, Adam, Sznajder, Pawel, Tandogan, Asli, Tawabutr, Yossathorn, Tawfik, A., Terry, John, Toll, Tobias, Tomalak, Oleksandr, Twagirayezu, Fidele, Venugopalan, Raju, Vitev, Ivan, Vladimirov, Alexey, Vogelsang, Werner, Vogt, Ramona, Vujanovic, Gojko, Waalewijn, Wouter, Wang, Xiang-Peng, Xiao, Bo-Wen, Xing, Hongxi, Yang, Yi-Bo, Yao, Xiaojun, Yuan, Feng, Zhao, Yong, and Zurita, Pia
Abstract: We outline the physics opportunities provided by the Electron Ion Collider (EIC). These include the study of the parton structure of the nucleon and nuclei, the onset of gluon saturation, the production of jets and heavy flavor, hadron spectroscopy and tests of fundamental symmetries. We review the present status and future challenges in EIC theory that have to be addressed in order to realize this ambitious and impactful physics program, including how to engage a diverse and inclusive workforce. In order to address these many-fold challenges, we propose a coordinated effort involving theory groups with differing expertise is needed. We discuss the scientific goals and scope of such an EIC Theory Alliance., Comment: 44 pages, ReVTeX, White Paper on EIC Theory Alliance
Published: 2023

18. Hadronization dynamics from the spectral representation of the gauge invariant quark propagator

Author: Costa, Caroline S. R., Accardi, Alberto, Signori, Andrea, Costa, Caroline S. R., Accardi, Alberto, and Signori, Andrea
Abstract: Using the spectral representation of the quark propagator we study the Dirac decomposition of the gauge invariant quark propagator, whose imaginary part describes the hadronization of a quark as this interacts with the vacuum. We then demonstrate the formal gauge invariance of the so-called jet mass, that is of the coefficient of the chiral-odd part of the gauge invariant propagator, that can be expressed in any gauge as the first moment of the chiral-odd quark spectral function. This is therefore revealed to be a \textit{bona fide} QCD observable encoding aspects of the dynamical mass generation in the QCD vacuum, and is furthermore experimentally measurable in specific twist-3 longitudinal-transverse asymmetries in DIS and in semi-inclusive electron-positron collisions. In light-like axial gauges, we also obtain a new sum rule for the spectral function associated with the gauge fixing vector. We finally present a gauge-dependent formula that connects the second moment of the chiral-even coefficient of the quark spectral function to invariant mass generation and final state rescattering in the hadronization of a quark. Finding twist-4 experimental observables sensitive to this quantity is left for future work., Comment: Contribution to DIS2023: XXX International Workshop on Deep-Inelastic Scattering and Related Subjects, Michigan State University, USA, 27-31 March 2023
Published: 2023

19. Strong Interaction Physics at the Luminosity Frontier with 22 GeV Electrons at Jefferson Lab

Author: Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avagyan, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F, Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J, Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M, Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, Lei, Chatagnon, P., Chen, C., Chen, J-P, Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z. -F., D'Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J, Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K, Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G. -P., Girod, F-X, Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F. -K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J. -O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Blin, A. N. Hiller, Hobart, A., Hobbs, T., Holmberg, D. E, Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G, Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, DJ, Jeschonnek, S., Ji, C-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D, Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H. -W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L, Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, H., Mkrtchyan, A., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A, Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B, Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S. -X., Qiu, J. -W., Radici, M., Rashidi, H., Rathnayake, A. D, Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J. -M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M, Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C, Seay, D. A, Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S, Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P, Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. -S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X. -B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S. -S., Ye, Z., Yero, C., Yuan, C. -P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Z. W., Zhao, Y., Zheng, X., Zhou, X., Ziegler, V., Zihlmann, B., de Paula, W, de Téramond, G. F., Accardi, A., Achenbach, P., Adhikari, D., Afanasev, A., Akondi, C. S., Akopov, N., Albaladejo, M., Albataineh, H., Albrecht, M., Almeida-Zamora, B., Amaryan, M., Androić, D., Armstrong, W., Armstrong, D. S., Arratia, M., Arrington, J., Asaturyan, A., Austregesilo, A., Avagyan, H., Averett, T., Gayoso, C. Ayerbe, Bacchetta, A., Balantekin, A. B., Baltzell, N., Barion, L., Barry, P. C., Bashir, A., Battaglieri, M., Bellini, V., Belov, I., Benhar, O., Benkel, B., Benmokhtar, F, Bentz, W., Bertone, V., Bhatt, H., Bianconi, A., Bibrzycki, L., Bijker, R., Binosi, D., Biswas, D., Boër, M., Boeglin, W., Bogacz, S. A., Boglione, M., Bondí, M., Boos, E. E., Bosted, P., Bozzi, G., Brash, E. J., Briceño, R. A., Brindza, P. D., Briscoe, W. J., Brodsky, S. J, Brooks, W. K., Burkert, V. D., Camsonne, A., Cao, T., Cardman, L. S., Carman, D. S., Carpinelli, M, Cates, G. D., Caylor, J., Celentano, A., Celiberto, F. G., Cerutti, M., Chang, Lei, Chatagnon, P., Chen, C., Chen, J-P, Chetry, T., Christopher, A., Christy, E., Chudakov, E., Cisbani, E., Cloët, I. C., Cobos-Martinez, J. J., Cohen, E. O., Colangelo, P., Cole, P. L., Constantinou, M., Contalbrigo, M., Costantini, G., Cosyn, W., Cotton, C., Courtoy, A., Dusa, S. Covrig, Crede, V., Cui, Z. -F., D'Angelo, A., Döring, M., Dalton, M. M., Danilkin, I., Davydov, M., Day, D., De Fazio, F., De Napoli, M., De Vita, R., Dean, D. J., Defurne, M., Deur, A., Devkota, B., Dhital, S., Di Nezza, P., Diefenthaler, M., Diehl, S., Dilks, C., Ding, M., Djalali, C., Dobbs, S., Dupré, R., Dutta, D., Edwards, R. G., Egiyan, H., Ehinger, L., Eichmann, G., Elaasar, M., Elouadrhiri, L., Alaoui, A. El, Fassi, L. El, Emmert, A., Engelhardt, M., Ent, R., Ernst, D. J, Eugenio, P., Evans, G., Fanelli, C., Fegan, S., Fernández-Ramírez, C., Fernandez, L. A., Fernando, I. P., Filippi, A., Fischer, C. S., Fogler, C., Fomin, N., Frankfurt, L., Frederico, T., Freese, A., Fu, Y., Gamberg, L., Gan, L., Gao, F., Garcia-Tecocoatzi, H., Gaskell, D., Gasparian, A., Gates, K, Gavalian, G., Ghoshal, P. K., Giachino, A., Giacosa, F., Giannuzzi, F., Gilfoyle, G. -P., Girod, F-X, Glazier, D. I., Gleason, C., Godfrey, S., Goity, J. L., Golubenko, A. A., Gonzàlez-Solís, S., Gothe, R. W., Gotra, Y., Griffioen, K., Grocholski, O., Grube, B., Guèye, P., Guo, F. -K., Guo, Y., Guo, L., Hague, T. J., Hammoud, N., Hansen, J. -O., Hattawy, M., Hauenstein, F., Hayward, T., Heddle, D., Heinrich, N., Hen, O., Higinbotham, D. W., Higuera-Angulo, I. M., Blin, A. N. Hiller, Hobart, A., Hobbs, T., Holmberg, D. E, Horn, T., Hoyer, P., Huber, G. M., Hurck, P., Hutauruk, P. T. P., Ilieva, Y., Illari, I., Ireland, D. G, Isupov, E. L., Italiano, A., Jaegle, I., Jarvis, N. S., Jenkins, DJ, Jeschonnek, S., Ji, C-R., Jo, H. S., Jones, M., Jones, R. T., Jones, D. C., Joo, K., Junaid, M., Kageya, T., Kalantarians, N., Karki, A., Karyan, G., Katramatou, A. T., Kay, S. J. D, Kazimi, R., Keith, C. D., Keppel, C., Kerbizi, A., Khachatryan, V., Khanal, A., Khandaker, M., Kim, A., Kinney, E. R., Kohl, M., Kotzinian, A., Kriesten, B. T., Kubarovsky, V., Kubis, B., Kuhn, S. E., Kumar, V., Kutz, T., Leali, M., Lebed, R. F., Lenisa, P., Leskovec, L., Li, S., Li, X., Liao, J., Lin, H. -W., Liu, L., Liuti, S., Liyanage, N., Lu, Y., MacGregor, I. J. D., Mack, D. J., Maiani, L, Mamo, K. A., Mandaglio, G., Mariani, C., Markowitz, P., Marukyan, H., Mascagna, V., Mathieu, V., Maxwell, J., Mazouz, M., McCaughan, M., McKeown, R. D., McKinnon, B., Meekins, D., Melnitchouk, W., Metz, A., Meyer, C. A., Meziani, Z. -E., Mezrag, C., Michaels, R., Miller, G. A., Mineeva, T., Miramontes, A. S., Mirazita, M., Mizutani, K., Mkrtchyan, H., Mkrtchyan, A., Moffit, B., Mohanmurthy, P., Mokeev, V. I., Monaghan, P., Montaña, G., Montgomery, R., Moretti, A., Chàvez, J. M. Morgado, Mosel, U., Movsisyan, A., Musico, P., Nadeeshani, S. A, Nadolsky, P. M., Nakamura, S. X., Nazeer, J., Nefediev, A. V., Neupane, K., Nguyen, D., Niccolai, S., Niculescu, I., Niculescu, G., Nocera, E. R., Nycz, M., Olness, F. I., Ortega, P. G., Osipenko, M., Pace, E., Pandey, B, Pandey, P., Papandreou, Z., Papavassiliou, J., Pappalardo, L. L., Paredes-Torres, G., Paremuzyan, R., Park, S., Parsamyan, B., Paschke, K. D., Pasquini, B., Passemar, E., Pasyuk, E., Patel, T., Paudel, C., Paul, S. J., Peng, J-C., Pentchev, L., Perrino, R., Perry, R. J., Peters, K., Petratos, G. G., Phelps, W., Piasetzky, E., Pilloni, A., Pire, B., Pitonyak, D., Pitt, M. L., Polosa, A. D., Pospelov, M., Postuma, A. C., Poudel, J., Preet, L., Prelovsek, S., Price, J. W., Prokudin, A., Puckett, A. J. R., Pybus, J. R., Qin, S. -X., Qiu, J. -W., Radici, M., Rashidi, H., Rathnayake, A. D, Raue, B. A., Reed, T., Reimer, P. E., Reinhold, J., Richard, J. -M., Rinaldi, M., Ringer, F., Ripani, M., Ritman, J., West, J. Rittenhouse, Rivero-Acosta, A., Roberts, C. D., Rodas, A., Rodini, S., Rodríguez-Quintero, J., Rogers, T. C., Rojo, J., Rossi, P., Rossi, G. C., Salmè, G., Santiesteban, S. N., Santopinto, E., Sargsian, M., Sato, N., Schadmand, S., Schmidt, A., Schmidt, S. M, Schnell, G., Schumacher, R. A., Schweitzer, P., Scimemi, I., Scott, K. C, Seay, D. A, Segovia, J., Semenov-Tian-Shansky, K., Seryi, A., Sharda, A. S, Shepherd, M. R., Shirokov, E. V., Shrestha, S., Shrestha, U., Shvedunov, V. I., Signori, A., Slifer, K. J., Smith, W. A., Somov, A., Souder, P., Sparveris, N., Spizzo, F., Spreafico, M., Stepanyan, S., Stevens, J. R., Strakovsky, I. I., Strauch, S., Strikman, M., Su, S., Sumner, B. C. L., Sun, E., Suresh, M., Sutera, C., Swanson, E. S., Szczepaniak, A. P, Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. -S., Tadevosyan, V., Tamang, B., Tarasov, V. V., Thiel, A., Tong, X. -B., Tyson, R., Ungaro, M., Urciuoli, G. M., Usman, A., Valcarce, A., Vallarino, S., Vaquera-Araujo, C. A., Venturelli, L., Vera, F., Vladimirov, A., Vossen, A., Wagner, J., Wei, X., Weinstein, L. B., Weiss, C., Williams, R., Winney, D., Wojtsekhowski, B., Wood, M. H., Xiao, T., Xu, S. -S., Ye, Z., Yero, C., Yuan, C. -P., Yurov, M., Zachariou, N., Zhang, Z., Zhao, Z. W., Zhao, Y., Zheng, X., Zhou, X., Ziegler, V., Zihlmann, B., de Paula, W, and de Téramond, G. F.
Abstract: This document presents the initial scientific case for upgrading the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab (JLab) to 22 GeV. It is the result of a community effort, incorporating insights from a series of workshops conducted between March 2022 and April 2023. With a track record of over 25 years in delivering the world's most intense and precise multi-GeV electron beams, CEBAF's potential for a higher energy upgrade presents a unique opportunity for an innovative nuclear physics program, which seamlessly integrates a rich historical background with a promising future. The proposed physics program encompass a diverse range of investigations centered around the nonperturbative dynamics inherent in hadron structure and the exploration of strongly interacting systems. It builds upon the exceptional capabilities of CEBAF in high-luminosity operations, the availability of existing or planned Hall equipment, and recent advancements in accelerator technology. The proposed program cover various scientific topics, including Hadron Spectroscopy, Partonic Structure and Spin, Hadronization and Transverse Momentum, Spatial Structure, Mechanical Properties, Form Factors and Emergent Hadron Mass, Hadron-Quark Transition, and Nuclear Dynamics at Extreme Conditions, as well as QCD Confinement and Fundamental Symmetries. Each topic highlights the key measurements achievable at a 22 GeV CEBAF accelerator. Furthermore, this document outlines the significant physics outcomes and unique aspects of these programs that distinguish them from other existing or planned facilities. In summary, this document provides an exciting rationale for the energy upgrade of CEBAF to 22 GeV, outlining the transformative scientific potential that lies within reach, and the remarkable opportunities it offers for advancing our understanding of hadron physics and related fundamental phenomena., Comment: Updates to the list of authors; Preprint number changed from theory to experiment; Updates to sections 4 and 6, including additional figures
Published: 2023

20. Gauge invariant spectral analysis of quark hadronization dynamics

Author: Accardi, Alberto, Costa, Caroline S. R., Signori, Andrea, Accardi, Alberto, Costa, Caroline S. R., and Signori, Andrea
Abstract: We study the Dirac decomposition of the gauge invariant quark propagator, whose imaginary part describes the hadronization of a quark as this interacts with the vacuum, and relate each of its coefficients to a specific sum rule for the chiral-odd and chiral-even quark spectral functions. Working at first in light-like axial gauge, we obtain a new sum rule for the spectral function associated to the gauge fixing vector, and show that its second moment is in fact equal to zero. Then, we demonstrate that the first moment of the chiral-odd quark spectral function is equal in any gauge to the so-called inclusive jet mass, which is related to the mass of the particles produced in the hadronization of a quark. Finally, we present a gauge-dependent formula that connects the second moment of the chiral-even quark spectral function to invariant mass generation and final state rescattering in the hadronization of a quark., Comment: 16 pages
Published: 2023

21. Carbon monoxide profile variability over the Manaus Metropolitan Region and its relations with biomass burning

Author: Signori, Renato Trevisan, Souza, Rodrigo Augusto Ferreira de, Souza, Rita Valeria Andreoli de, Ribeiro, Igor Oliveira, Toshie Kayano, Mary, Signori, Renato Trevisan, Souza, Rodrigo Augusto Ferreira de, Souza, Rita Valeria Andreoli de, Ribeiro, Igor Oliveira, and Toshie Kayano, Mary
Abstract: The present study analyzes the temporal variability of carbon monoxide (CO) over the Manaus Metropolitan Region (MMR) and its relations with nearby fires based on data obtained by the environmental satellite AQUA, for the 2003–2020 period. For this purpose, wavelet transform analyses and wavelet coherence analyses were used. The results show a well-defined seasonal behavior, with an increase and decrease in mean CO concentrations during dry and wet seasons, respectively. Semiannual and annual scales represent around 95 % of CO temporal variability in lower troposphere (500 to 1,000 hPa) and are associated with rains and fires dynamics in the region. In terms of interannual variability, multiple variability scales (1.2–2, 2.5–3 and 4.5–6 years) were observed, which explain around 10–15 % of concentration variability near surface. The results suggest that climatic variations, associated with the tropical Pacific and Atlantic sea surface temperature variations, on these different time scales, affect rain dynamics and, consequently, fires and CO concentration. Specifically, in 2015/16, the combined effect from different variability scales acted to prolong the dry period over the region, which contributed to increase fires and the CO to reach higher values compared to previous years. These results show a new aspect of the importance of evaluating the combined effect of different climate variability scales on CO concentrations in the atmosphere., O presente estudo analisa a variabilidade temporal do gás monóxido de carbono (CO) sobre a Região Metropolitana de Manaus (RMM) e sua relação com as queimadas com base em informações obtidas pelo satélite ambiental AQUA, para o período entre 2003 e 2020. Para tal, foram realizadas análises de transformada de ondeleta e análises de coerência e fase da ondeleta. Os resultados apontam para um comportamento sazonal bem definido, com aumento das concentrações médias de CO durante a estação seca e redução na estação chuvosa. As escalas semianual e anual representam cerca de 95% da variabilidade temporal do CO na baixa troposfera (500 a 1.000 hPa) e estão associadas à dinâmica das chuvas e queimadas na região. Com relação à variabilidade interanual, observaram-se múltiplas escalas de variabilidade (1,2–2, 2,5–3 e 4,5–6 anos), que explicam juntas em torno de 10–15 % da variabilidade das concentrações próximas à superfície. Os resultados sugerem que variações climáticas, associadas às variações da temperatura da superfície do mar nos oceanos Pacífico e Atlântico tropicais, nessas diferentes escalas de tempo, afetam a dinâmica das chuvas e, consequentemente, as queimadas e a concentração de CO. Especificamente em 2015/16, o efeito combinado das diferentes escalas de variabilidade atuou para prolongar o período seco sobre a região, o que contribuiu para o aumento das queimadas e para que o CO alcançasse maiores valores em relação aos anos anteriores. Tais resultados mostram um aspecto novo sobre a importância de avaliar o efeito combinado de diferentes escalas de variabilidade climática nas concentrações de CO na atmosfera, particularmente em anos extremos.
Published: 2023

22. La riforma Gentile e gli studi giuridici: una palingenesi mancata

Author: Mattone, A, Moretti, M, Signori, E, Chiodi, G, Mattone, A, Moretti, M, Signori, E, and Chiodi, G
Abstract: Dal punto di vista delle Facoltà di Giurisprudenza, la riforma Gentile dell’istruzione superiore fu punto di arrivo e nello stesso tempo blocco di partenza di ulteriori progetti politici, alla ricerca di soluzioni a problemi fondamentali, spesso etichettati come generati da crisi e decadenza degli studi giuridici, quali l’autonomia dell’organizzazione; il sistema di reclutamento dei professori; la funzione della facoltà (il modello di educazione: culturale o professionale?); il valore dei titoli accademici; il metodo didattico (lezioni, esercitazioni ed esami); l’autonomia degli studenti rispetto al piano di studi; il rapporto tra laurea ed esame di stato; l’affermarsi dell’università di massa con il conseguente problema dell’affollamento dei corsi (riduzione delle facoltà o numero chiuso?); il rapporto tra Giurisprudenza e la Facoltà di scienze politiche. Per approfondire tali questioni, che assumono una peculiare curvatura nel campo giuridico, si isolano dal dibattito da una parte alcuni interventi degli addetti ai lavori più vicini al regime e dall’altra le riflessioni dei giuristi che, anche per il ruolo occupato nell’università e quindi per l’esperienza maturata, ne discussero con speciale cognizione di causa., From the point of view of the Faculties of Law, the Gentile Reform of higher education was the point of arrival and at the same time the starting block for further political projects, in search of solutions to fundamental problems, often labelled as generated by the crisis and decadence of legal studies, such as the autonomy of the organisation; the system of recruiting professors; the function of the faculty (the model of education: cultural or professional? ); the value of academic qualifications; the teaching method (lectures, tutorials and examinations); the autonomy of students with respect to the syllabus; the relationship between degrees and State examinations; the emergence of the mass university with the consequent problem of course crowding (reduction of faculties or limited number?); the relationship between Law and the Faculty of Political Sciences. In order to examine these issues, which take on a peculiar bent in the field of law, the essay isolates from the debate on the one hand some interventions by insiders closer to the regime and on the other hand the reflections of jurists who, also because of the role they occupied in the university and thus because of the experience they gained, discussed them with special insight.
Published: 2023

23. System architecture and communication infrastructure for the RoboVaaS project

Author: Coccolo, Emanuele, Delea, Cosmin, Steinmetz, Fabian, Francescon, Roberto, Signori, Alberto, Nok Au, Ching, Campagnaro, Filippo, Schneider, Vincent Emanuel, Favaro, Federico, Oeffner, Johannes, Renner, Bernd-Christian, Zorzi, Michele, Coccolo, Emanuele, Delea, Cosmin, Steinmetz, Fabian, Francescon, Roberto, Signori, Alberto, Nok Au, Ching, Campagnaro, Filippo, Schneider, Vincent Emanuel, Favaro, Federico, Oeffner, Johannes, Renner, Bernd-Christian, and Zorzi, Michele
Abstract: This is to notify you that the following article, "System Architecture and Communication Infrastructure for the RoboVaaS Project," has been finalized and posted to the "Early Access" area on IEEE Xplore. This article has been accepted for inclusion in a future issue of this journal and its content is final as presented with the exception of pagination and issue designation. It may be cited as an article in a future issue by its Digital Object Identifier.
Published: 2023

24. Heterogeneity on long-term disability trajectories in patients with secondary progressive MS:a latent class analysis from Big MS Data network

Author: Signori, Alessio, Lorscheider, Johannes, Vukusic, Sandra, Trojano, Maria, Iaffaldano, Pietro, Hillert, Jan, Hyde, Robert, Pellegrini, Fabio, Magyari, Melinda, Koch-Henriksen, Nils, Sørensen, Per Soelberg, Spelman, Tim, Van Der Walt, Anneke, Horakova, Dana, Havrdova, Eva, Girard, Marc, Eichau, Sara, Grand'maison, Francois, Gerlach, Oliver, Terzi, Murat, Ozakbas, Serkan, Skibina, Olga, Van Pesch, Vincent, Sa, Maria Jose, Prevost, Julie, Alroughani, Raed, McCombe, Pamela A., Gouider, Riadh, Mrabet, Saloua, Castillo-Trivino, Tamara, Zhu, Chao, De Gans, Koen, Sánchez-Menoyo, José Luis, Yamout, Bassem, Khoury, Samia, Sormani, Maria Pia, Kalincik, Tomas, Butzkueven, Helmut, Signori, Alessio, Lorscheider, Johannes, Vukusic, Sandra, Trojano, Maria, Iaffaldano, Pietro, Hillert, Jan, Hyde, Robert, Pellegrini, Fabio, Magyari, Melinda, Koch-Henriksen, Nils, Sørensen, Per Soelberg, Spelman, Tim, Van Der Walt, Anneke, Horakova, Dana, Havrdova, Eva, Girard, Marc, Eichau, Sara, Grand'maison, Francois, Gerlach, Oliver, Terzi, Murat, Ozakbas, Serkan, Skibina, Olga, Van Pesch, Vincent, Sa, Maria Jose, Prevost, Julie, Alroughani, Raed, McCombe, Pamela A., Gouider, Riadh, Mrabet, Saloua, Castillo-Trivino, Tamara, Zhu, Chao, De Gans, Koen, Sánchez-Menoyo, José Luis, Yamout, Bassem, Khoury, Samia, Sormani, Maria Pia, Kalincik, Tomas, and Butzkueven, Helmut
Abstract: Background Over the decades, several natural history studies on patients with primary (PPMS) or secondary progressive multiple sclerosis (SPMS) were reported from international registries. In PPMS, a consistent heterogeneity on long-term disability trajectories was demonstrated. The aim of this study was to identify subgroups of patients with SPMS with similar longitudinal trajectories of disability over time. Methods All patients with MS collected within Big MS registries who received an SPMS diagnosis from physicians (cohort 1) or satisfied the Lorscheider criteria (cohort 2) were considered. Longitudinal Expanded Disability Status Scale (EDSS) scores were modelled by a latent class growth analysis (LCGA), using a non-linear function of time from the first EDSS visit in the range 3-4. Results A total of 3613 patients with SPMS were included in the cohort 1. LCGA detected three different subgroups of patients with a mild (n=1297; 35.9%), a moderate (n=1936; 53.6%) and a severe (n=380; 10.5%) disability trajectory. Median time to EDSS 6 was 12.1, 5.0 and 1.7 years, for the three groups, respectively; the probability to reach EDSS 6 at 8 years was 14.4%, 78.4% and 98.3%, respectively. Similar results were found among 7613 patients satisfying the Lorscheider criteria. Conclusions Contrary to previous interpretations, patients with SPMS progress at greatly different rates. Our identification of distinct trajectories can guide better patient selection in future phase 3 SPMS clinical trials. Additionally, distinct trajectories could reflect heterogeneous pathological mechanisms of progression.
Published: 2023

25. EFFECTS OF MOTIVATIONAL MUSIC ON PERCEIVED EXERTION DURING AEROBIC EXERCISE

Author: Gallazzi, Marta, Signori, Clara, Vukaj, Xhuljano, Andriolo, Greta, Grignani, Leonardo, Figini, Andrea, Cantarelli, Davide, Baratti, Mirko, Ghirardi, Paolo, Bruseghini, Paolo, Annoni, Isabella, Bertozzi, Filippo, Castenetto, Michelle, Galvani, Christel, BRUSEGHINI PAOLO (ORCID:0000-0003-0285-5443), BERTOZZI FILIPPO, GALVANI CHRISTEL (ORCID:0000-0002-0126-6033), Gallazzi, Marta, Signori, Clara, Vukaj, Xhuljano, Andriolo, Greta, Grignani, Leonardo, Figini, Andrea, Cantarelli, Davide, Baratti, Mirko, Ghirardi, Paolo, Bruseghini, Paolo, Annoni, Isabella, Bertozzi, Filippo, Castenetto, Michelle, Galvani, Christel, BRUSEGHINI PAOLO (ORCID:0000-0003-0285-5443), BERTOZZI FILIPPO, and GALVANI CHRISTEL (ORCID:0000-0002-0126-6033)
Abstract: INTRODUCTION: Music is associated with improved physical performance in a wide range of activities. When music is used during physical activity, it can elicit positive emotions and distract athletes from unpleasant feelings associated with physical exertion and fatigue(1). Some evidence shows no effect of time of day on the rating of perceived exertion (RPE) during aerobic performances(2). The aim of this study was to test the influence of self-selected motivational music, and time of training on RPE during a cycling exercise at moderate and vigorous intensity. METHODS: Forty-seven university students were recruited: 24 males and 23 females (age 22.6±2.4 yrs; BMI 21.9±2.7 kg/m2; V’O2max 39.3±7.6 mlO2/kg/min). All subjects performed four randomized training sessions at two different times of day, with and without self-selected motivational music(3): two sessions in the morning from 8:30 am to 9:30 am (MO+M; MO-M) and two sessions in the evening from 5:30 pm to 6:30 pm (EV+M; EV-M). Each training session included 6 min of cycling at constant load at 60% of V’O2max (MOD), interspersed by a 10-min break, and at 90% (VIG) of V’O2max, estimated from a submaximal direct test. At the end of each 6-min bout, CR10 Borg’s scale(4) was administrated to rate fatigue. RESULTS: RPE was significantly influenced by music, indeed it decreased during exercise performed with self-selected motivational music both at MOD (MO+M: 2.3±1.2; MO-M: 2.6±1.3; EV+M: 2.2±1.1; EV-M: 2.5±1.3; p=0.025) and VIG (MO+M: 6.1±2.0; MO-M: 6.8±1.9; EV+M: 6.5±2.1; EV-M: 6.7±2.0; p=0.001) intensity, regardless of gender. Conversely, time of day did not influence RPE neither at MOD nor at VIG intensity, in both gender. CONCLUSION: This research, taking into account both the influence of music and of time of day, confirms previous find-ings of a positive effect of motivational music(5) and no influence of time of day(2) on RPE. Exercisers are advised to listen to self-selected motivational music while training
Published: 2023

26. Combined forced diuresis and late acquisition on [$^{68}$Ga]Ga-PSMA-11 PET/CT for biochemical recurrent prostate cancer: a clinical practice-oriented study

Author: Bauckneht, Matteo; https://orcid.org/0000-0002-1937-9116, Miceli, Alberto, Signori, Alessio, Albano, Domenico, Capitanio, Selene, Piva, Roberta, Laudicella, Riccardo; https://orcid.org/0000-0002-2842-0301, Franchini, Annalisa, D'Amico, Francesca, Riondato, Mattia, Chiola, Silvia, Marini, Cecilia, Fornarini, Giuseppe, Scarale, Antonio, Muni, Alfredo, Bertagna, Francesco, Burger, Irene A; https://orcid.org/0000-0001-8029-8692, Sambuceti, Gianmario, Morbelli, Silvia, Bauckneht, Matteo; https://orcid.org/0000-0002-1937-9116, Miceli, Alberto, Signori, Alessio, Albano, Domenico, Capitanio, Selene, Piva, Roberta, Laudicella, Riccardo; https://orcid.org/0000-0002-2842-0301, Franchini, Annalisa, D'Amico, Francesca, Riondato, Mattia, Chiola, Silvia, Marini, Cecilia, Fornarini, Giuseppe, Scarale, Antonio, Muni, Alfredo, Bertagna, Francesco, Burger, Irene A; https://orcid.org/0000-0001-8029-8692, Sambuceti, Gianmario, and Morbelli, Silvia
Abstract: OBJECTIVES Increased detection of prostate cancer (PCa) recurrences using [$^{68}$Ga]Ga-PSMA-11 PET/CT has been reported by adding forced diuresis or late-phase imaging to the standard protocol. However, the combination of these procedures in the clinical setting is still not standardized. METHODS One hundred prospectively recruited biochemical recurrent PCa patients were restaged with dual-phase [$^{68}$Ga]Ga-PSMA-11 PET/CT from September 2020 to October 2021. All patients received a standard scan (60 min), followed by diuretics (140 min) and a late-phase abdominopelvic scan (180 min). PET readers with low (n = 2), intermediate (n = 2), or high (n = 2) experience rated (i) standard and (ii) standard + forced diuresis late-phase images in a stepwise fashion according to E-PSMA guidelines, scoring their level of confidence. Study endpoints were (i) accuracy against a composite reference standard, (ii) reader's confidence level, and (iii) interobserver agreement. RESULTS Forced diuresis late-phase imaging increased the reader's confidence category for local and nodal restaging (both p < 0.0001), and the interobserver agreement in identifying nodal recurrences (from moderate to substantial, p < 0.01). However, it significantly increased diagnostic accuracy exclusively for local uptakes rated by low-experienced readers (from 76.5 to 84%, p = 0.05) and for nodal uptakes rated as uncertain at standard imaging (from 68.1 to 78.5%, p < 0.05). In this framework, SUVmax kinetics resulted in an independent predictor of PCa recurrence compared to standard metrics, potentially guiding the dual-phase PET/CT interpretation. CONCLUSIONS The present results do not support the systematic combination of forced diuresis and late-phase imaging in the clinical setting, but allow the identification of patients-, lesions-, and reader-based scenarios that might benefit from it. KEY POINTS • Increased detection of prostate cancer recurrences has been reported by adding diuretics administrati
Published: 2023

27. Steroids in severe COVID-19 patients: A retrospective analysis on the first pandemics in Lombardy

Author: Vergnano, B, Calcinati, S, Signori, D, Benini, A, Pozzi, M, Verga, L, Pizzagalli, J, Bonfanti, P, Bellani, G, Foti, G, Vergnano, Beatrice, Calcinati, Serena, Signori, Davide, Benini, Annalisa, Pozzi, Maria Rosa, Verga, Luisa, Pizzagalli, Jonata, Bonfanti, Paolo, Bellani, Giacomo, Foti, Giuseppe, Vergnano, B, Calcinati, S, Signori, D, Benini, A, Pozzi, M, Verga, L, Pizzagalli, J, Bonfanti, P, Bellani, G, Foti, G, Vergnano, Beatrice, Calcinati, Serena, Signori, Davide, Benini, Annalisa, Pozzi, Maria Rosa, Verga, Luisa, Pizzagalli, Jonata, Bonfanti, Paolo, Bellani, Giacomo, and Foti, Giuseppe
Abstract: The pathogenesis of COVID-19 appears to be characterized by a dysregulated immune response. During the first pandemic wave in Lombardy, we started to administer glucocorticoids to some patients with severe respiratory failure requiring support with Continuous Positive Airway Pressure (CPAP) therapy. We retrospectively collected data to identify the effect of glucocorticoids in this COVID-19 particular population. With a multidisciplinary consensus, we administered to selected patients with severe COVID-19 disease (PaO2/FiO2 159±71 mmHg) 0,91 mg/kg/die of methylprednisolone equivalent dose after a median of 8 days of hospitalization. In our study we compared 57 patients from the steroid group with 123 from the control group: the event of invasive mechanical ventilation or death was reduced by 43% between steroid group and control group (19.3 % vs. 34.1 % respectively, p=0.001) and mortality was reduced by about 31% between steroid and usual care alone (15.8 % vs. 22.8 % respectively, p=0.011). Corticosteroids in selected COVID-19 patients may have a relevant impact on outcome, better profiling of the heterogeneity of this disease may be essential to guarantee the best treatment choices.
Published: 2021

28. Julius Robert Mayer and the principle of energy conservation

Author: Aquilini, E, Cosentino, U, Pasqualetti, N, Signori, F, Aquilini E., Cosentino U., Pasqualetti N., Signori F., Aquilini, E, Cosentino, U, Pasqualetti, N, Signori, F, Aquilini E., Cosentino U., Pasqualetti N., and Signori F.
Abstract: Julius Robert von Mayer was among the first to state the principle of energy conservation. As a medical doctor, he was interested in the relationship between heat and work, being stimulated by observations and considerations regarding the physiology of the human body. In 1842, he published a first manuscript in which he reported the value of the mechanical equivalent of heat; then, in a paper in 1845, he elucidated the procedure followed for the calculation of the equivalent. The result achieved by Mayer, based only on theoretical calculations, was presented before the experimentally determined value obtained by Joule in 1847 and remains of capital interest in the history of thermodynamics.
Published: 2021

29. Modified pediatric Lung Ultrasound Score compared with computed tomography for assessment of lung aeration in children

Author: Fochi, O, Bronco, A, Nacoti, M, Signori, D, Gatti, S, Sala, F, Rozen, T, Bonanomi, E, Bellani, G, Fochi, Oliviero, Bronco, Alfio, Nacoti, Mirco, Signori, Davide, Gatti, Stefano, Sala, Francesco, Rozen, Thomas, Bonanomi, Ezio, Bellani, Giacomo, Fochi, O, Bronco, A, Nacoti, M, Signori, D, Gatti, S, Sala, F, Rozen, T, Bonanomi, E, Bellani, G, Fochi, Oliviero, Bronco, Alfio, Nacoti, Mirco, Signori, Davide, Gatti, Stefano, Sala, Francesco, Rozen, Thomas, Bonanomi, Ezio, and Bellani, Giacomo
Abstract: BACKGROUND: Lung ultrasound can be used to assess lung density and aeration at the bedside. A few authors have investigated scores based on the ultrasonographic interstitial syndrome for this purpose, but none have compared them with the gold standard computed tomography in children.METHODS: Children < 10 kilograms undergoing a chest computed tomography for clinical purposes at a tertiary hospital Pediatric Intensive Care Unit were enrolled in the study. An ultrasound scan was performed shortly after computed tomography. Each hemithorax was divided in 6 zones, and each zone was scored: 1 = no B lines; 2 = < 3 B lines; 3 > 3 well separated B lines; 4 = crowded, coalescent B lines; 5 = white lung; 6 = consolidation. The pediatric Lung Ultrasound Score was obtained by adding all zones. Interobserver variation for two separate operators was calculated.RESULTS: Ten children, median age 95 days (range 23 - 721), were enrolled. Mean pediatric Lung Ultrasound Score had a significant correlation with lung density (rho = 0.68) and percentage of hypoaerated lung (rho = 0.51). Median density and percentage of hypoaerated lung increased along the ultrasound patterns values (p < 0.05) although not all patterns were significantly different from adjacent ones in the pairwise comparison. Interobserver variability in scoring of ultrasonographic patterns was moderate.CONCLUSIONS: The pediatric Lung Ultrasound Score correlates with lung density and percentage of hypoaerated lung measured with computed tomography.
Published: 2021

30. Reductions in CEO career horizons and corporate policies

Author: Aktas, N., Boone, A., Croci, Ettore, Signori, Andrea, Croci E. (ORCID:0000-0002-1221-2102), Signori A. (ORCID:0000-0002-7502-5451), Aktas, N., Boone, A., Croci, Ettore, Signori, Andrea, Croci E. (ORCID:0000-0002-1221-2102), and Signori A. (ORCID:0000-0002-7502-5451)
Abstract: We provide evidence on the effect of personal shocks that reduce a CEO's expected career horizon on corporate policies. The timing of these events is not predictable based on observable characteristics, and affected CEOs experience greater turnover rates and shorter residual time-in-office. Following the shock, these firms moderate both R&D and capital expenditures and increase cash distributions. While these changes are consistent with greater short-term orientation, they are not detrimental to shareholders, as performance increases after the shock. Earnings management and firm risk remain unchanged, while both CEO total compensation and equity-based compensation decline. Overall, our results indicates that the improved performance comes from the implementation of more efficient firm policies, likely driven by an internal tournament effect after the shock rather than from opportunistic behavior.
Published: 2021

31. Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population: Have we made progress?

Author: Vourli, G, Noori, T, Pharris, A, Porter, K, Axelsson, M, Begovac, J, Cazein, F, Costagliola, D, Cowan, S, Croxford, S, Monforte, A, Delpech, V, Diaz, A, Girardi, E, Gunsenheimer-Bartmeyer, B, Hernando, V, Leierer, G, Lot, F, Nunez, O, Obel, N, Op de Coul, E, Paraskeva, D, Patrinos, S, Reiss, P, Schmid, D, Sonnerborg, A, Suligoi, B, Supervie, V, van Sighem, A, Zangerle, R, Touloumi, G, Egle, A, Kanatschnig, M, Ollinger, A, Rieger, A, Schmied, B, Wallner, E, Dewasurendra, D, Gisinger, M, Kitchen, M, Plattner, A, Rieser, E, Sarcletti, M, Greil, R, Schachner, M, Skocic, M, Muller, M, Aichwalder, R, Chromy, D, Grabmeier-Pfstershammer, K, Skoll, M, Touzeau, V, Cichon, P, Wolf-Nussmuller, S, Laferl, H, Zoufaly, A, Genger-Hackl, C, Kapper, A, Schneeberger, T, Trattner, E, Schober, G, Atzl, M, Hartmann, B, Puchhammer-Stockl, E, Berg, J, Appoyer, H, Rappold, M, Strickner, S, Schindelwig, K, Ledergerber, B, Fatkenheuer, G, Gerstof, J, Kronborg, G, Pedersen, C, Larsen, C, Pedersen, G, Mohey, R, Nielsen, L, Weise, L, Kvinesdal, B, Jensen, J, Abgrall, S, Bernard, L, Billaud, E, Boue, F, Boyer, L, Cabie, A, Caby, F, Canestri, A, Cotte, L, de Truchis, P, Duval, X, Duvivier, C, Enel, P, Fischer, H, Gasnault, J, Gaud, C, Grabar, S, Khuong-Josses, M, Launay, O, Marchand, L, Mary-Krause, M, Matheron, S, Melica-Gregoire, G, Melliez, H, Meynard, J, Nacher, M, Pavie, J, Piroth, L, Poizot-Martin, I, Pradier, C, Reynes, J, Rouveix, E, Simon, A, Slama, L, Tattevin, P, Tissot-Dupont, H, Biga, J, Kurth, T, Jacquemet, N, Guiguet, M, Leclercq, S, Lievre, L, Marshall, E, Roul, H, Selinger-Leneman, H, Potard, V, Benveniste, O, Breton, G, Lupin, C, Bourzam, E, Girard, P, Fonquernie, L, Valin, N, Lefebvre, B, Sebire, M, Pialoux, G, Lebrette, M, Tibaut, P, Adda, A, Hamidi, M, Cadranel, J, Lavole, A, Parrot, A, Bouchaud, O, Vignier, N, Mechai, F, Makhlouf, S, Honore, P, Bergmann, J, Delcey, V, Lopes, A, Sellier, P, Parrinello, M, Oksenhendler, E, Gerard, L, Molina, J, Rozenbaum, W, Denis, B, De Castro, N, Lascoux, C, Yazdanpanah, Y, Lariven, S, Joly, V, Rioux, C, Poupard, M, Taverne, B, Sutton, L, Masse, V, Genet, P, Wifaq, B, Gerbe, J, Grefe, S, Dupont, C, Freire Maresca, A, Reimann, E, Bloch, M, Meier, F, Mortier, E, Zeng, F, Montoya, B, Perronne, C, Mathez, D, Marigot-Outtandy, D, Berthe, H, Greder Belan, A, Terby, A, Godin Collet, C, Marque Juillet, S, Ruquet, M, Roussin-Bretagne, S, Colardelle, P, Granier, F, Laurichesse, J, Perronne, V, Akpan, T, Marcou, M, Daneluzzi, V, Veyssier-Belot, C, Masson, H, Welker, Y, Brazille, P, Kahn, J, Zucman, D, Majerholc, C, Fourn, E, Bornarel, D, Chambrin, V, Kansau, I, Raho-Moussa, M, Lelievre, J, Saidani, M, Chesnel, C, Dumont, C, Vittecoq, D, Derradji, O, Bolliot, C, Goujard, C, Teicher, E, Mole, M, Bourdic, K, Salmon, D, Le Jeunne, C, Guet, P, Pietri, M, Pannier Metzger, E, Marcou, V, Loulergue, P, Dupin, N, Morini, J, Deleuze, J, Gerhardt, P, Chanal, J, Weiss, L, Lucas, M, Jung, C, Ptak, M, Viard, J, Ghosn, J, Gazalet, P, Cros, A, Maignan, A, Lortholary, O, Rouzaud, C, Touam, F, Benhadj, K, Consigny, P, Bossi, P, Gergely, A, Cessot, G, Durand, F, Beck-Wirth, G, Michel, C, Benomar, M, Rey, D, Partisani, M, Cheneau, C, Batard, M, Fischer, P, Leclercq, P, Blanc, M, Morand, P, Epaulard, O, Signori-Schmuck, A, Laurichesse, H, Jacomet, C, Vidal, M, Coban, D, Casanova, S, Fresard, A, Guglielminotti, C, Botelho-Nevers, E, Brunon-Gagneux, A, Ronat, V, Verdon, R, Dargere, S, Haustraete, E, Feret, P, Goubin, P, Chavanet, P, Fillion, A, Croisier, D, Gohier, S, Arvieux, C, Souala, F, Chapplain, J, Ratajczak, M, Rohan, J, Faller, J, Ruyer, O, Gendrin, V, Toko, L, Chirouze, C, Hustache-Mathieu, L, Faucher, J, Proust, A, Magy-Bertrand, N, Gil, H, Meaux-Ruault, N, Sotto, A, Rouanet, I, Mauboussin, J, Doncesco, R, Jacques, G, May, T, Rabaud, C, Andre, M, Delestan, M, Bouillon, M, Bani-Sadr, F, Rouger, C, Berger, J, Nguyen, Y, Marchou, B, Delobel, P, Martin Blondel, G, Cuzin, L, Biezunski, N, Alric, L, Bonnet, D, Guivarch, M, Palacin, A, Payssan, V, Ajana, F, Meybeck, A, Viget, N, Pugliese, P, Roger, P, Rosenthal, E, Durant, J, Cua, E, Naqvi, A, Perbost, I, Risso, K, Quinsat, D, Raphael, S, Del Giudice, P, Dides, P, Sambuc, R, Antolini-Bouvenot, M, Druart, P, Meddeb, L, Ravaux, I, Menard, A, Tomei, C, Dhiver, C, Moreau, J, Mokhtari, S, Soavi, M, Tomas, V, Bregigeon, S, Faucher, O, Obry-Roguet, V, Ritleng, A, Petit, N, Bartoli, C, Ruiz, J, Blanc, D, Allegre, T, Sordage, M, Riou, J, Faudon, C, Slama, B, Zerazhi, H, Boulat, O, Chebrek, S, Beyrne, M, Granet Brunello, P, Pellissier, L, Bonnabel, D, Cohen Valensi, R, Mouchet, B, Mboungou, G, Lafeuillade, A, Hope-Rapp, E, Hittinger, G, Philip, G, Lambry, V, Raf, F, Allavena, C, Hall, N, Reliquet, V, Chidiac, C, Ferry, T, Perpoint, T, Miailhes, P, Boibieux, A, Livrozet, J, Makhlouf, D, Brunel, F, Chiarello, P, Hoen, B, Lamaury, I, Fabre, I, Samar, K, Duvallon, E, Clavel, C, Stegmann, S, Walter, V, Adriouch, L, Huber, F, Vanticlke, V, Couppie, P, Abel, S, Pierre-Francois, S, Ricaud, C, Rodet, R, Wartel, G, Sautron, C, Poubeau, P, Borgherini, G, Camuset, G, Arasteh, K, Kowohl Vivantes, S, Schurmann, D, Warncke Charite, M, Rockstroh, J, Wasmuth, J, Hass, S, Jensen, B, Feind, C, Esser, S, Schenk-Westkamp, P, Haberl, A, Stephan, C, Plettenberg, A, Kuhlendahl, F, Adam, A, Weitner, L, Schewe, K, Goey, H, Fenske, S, Buhk, T, Stellbrink, H, Hofmann, C, Hansen, S, Degen, O, Heuer, M, Stoll, M, Gerschmann, S, Horst, H, Trautmann, S, Gillor, D, Bogner, J, Sonntag, B, Salzberger, B, Fritzsche, C, Adamis, G, Antoniadou, A, Chini, M, Chrysos, G, Gikas, A, Gogos, H, Katsarou, O, Lazanas, M, Metallidis, S, Panagopoulos, P, Paparizos, V, Papastamopoulos, V, Paraskevis, D, Psychogiou, M, Sambatakou, H, Sipsas, N, Pantazis, N, Papadopoulos, A, Nitsotolis, T, Xylomenos, G, Marangos, M, Kouramba, A, Kontos, A, Lioni, A, Tsachouridou, O, Kourkounti, S, Ganitis, A, Barbounakis, E, d'Arminio Monforte, A, Antinori, A, Andreoni, M, Castagna, A, Castelli, F, Cauda, R, Di Perri, G, Galli, M, Iardino, R, Ippolito, G, Lazzarin, A, Marchetti, G, Rezza, G, von Schloesser, F, Viale, P, Ceccherini-Silberstein, F, Cozzi-Lepri, A, Lo Caputo, S, Mussini, C, Puoti, M, Perno, C, Bai, F, Balotta, C, Bandera, A, Bonora, S, Borderi, M, Calcagno, A, Capetti, A, Capobianchi, M, Cicalini, S, Cingolani, A, Cinque, P, Di Biagio, A, Gianotti, N, Gori, A, Guaraldi, G, Lapadula, G, Lichtner, M, Madeddu, G, Maggiolo, F, Monno, L, Nozza, S, Pinnetti, C, Quiros Roldan, E, Rossotti, R, Rusconi, S, Santoro, M, Saracino, A, Sarmati, L, Fanti, I, Galli, L, Lorenzini, P, Rodano, A, Macchia, M, Tavelli, A, Carletti, F, Carrara, S, Di Caro, A, Graziano, S, Petroni, F, Prota, G, Trufa, S, Giacometti, A, Costantini, A, Barocci, V, Angarano, G, Milano, E, Suardi, C, Donati, V, Verucchi, G, Castelnuovo, F, Minardi, C, Menzaghi, B, Abeli, C, Cacopardo, B, Celesia, B, Vecchiet, J, Falasca, K, Pan, A, Lorenzotti, S, Sighinolf, L, Segala, D, Blanc, P, Vichi, F, Cassola, G, Viscoli, C, Alessandrini, A, Bobbio, N, Mazzarello, G, Fondaco, L, Bonfanti, P, Molteni, C, Chiodera, A, Milini, P, Nunnari, G, Pellicano, G, Rizzardini, G, Cannizzo, E, Moioli, M, Piolini, R, Bernacchia, D, Salpietro, S, Tincati, C, Puzzolante, C, Migliorino, C, Sangiovanni, V, Borgia, G, Esposito, V, Di Flumeri, G, Gentile, I, Rizzo, V, Cattelan, A, Marinello, S, Cascio, A, Trizzino, M, Francisci, D, Schiaroli, E, Parruti, G, Sozio, F, Magnani, G, Ursitti, M, Cristaudo, A, Vullo, V, Acinapura, R, Moschese, D, Capozzi, M, Mondi, A, Rivano Capparuccia, M, Iaiani, G, Latini, A, Gagliardini, R, Plazzi, M, De Girolamo, G, Vergori, A, Cecchetto, M, Viviani, F, De Vito, A, Rossetti, B, Montagnani, F, Franco, A, Fontana Del Vecchio, R, Di Giuli, C, Caramello, P, Orofno, G, Sciandra, M, Bassetti, M, Londero, A, Manfrin, V, Battagin, G, Starnini, G, Ialungo, A, van der Valk, M, Geerlings, S, Goorhuis, A, Hovius, J, Lempkes, B, Nellen, F, van der Poll, T, Prins, J, van Vugt, M, Wiersinga, W, Wit, F, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A, Pijnappel, F, Smalhout, S, Weijsenfeld, A, Jurriaans, S, Back, N, Zaaijer, H, Berkhout, B, Cornelissen, M, Schinkel, C, Wolthers, K, Peters, E, van Agtmael, M, Bomers, M, Sigalof, K, Heitmuller, M, Laan, L, Ang, C, van Houdt, R, Jonges, M, van Prehn, J, Kuijpers, T, Pajkrt, D, Scherpbier, H, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Loof, L, Wintermans, B, Veenemans, J, Pronk, M, Ammerlaan, H, de Munnik, E, Jansz, A, Tjhie, J, Wegdam, M, Deiman, B, Scharnhorst, V, van Eeden, A, Brokking, W, Elsenburg, L, Nobel, H, Damen, M, van Kasteren, M, Berrevoets, M, Brouwer, A, Adams, A, de Kruijf-Van de Wiel, B, Keelan-Pfaf, S, van der Ven, B, Buiting, A, Murck, J, Versteeg, D, de Vries-Sluijs, T, Bax, H, van Gorp, E, Nouwen, J, Rijnders, B, Schurink, C, Verbon, A, de Jong-Peltenburg, N, Bassant, N, van Beek, J, Vriesde, M, van Zonneveld, L, van den Berg-Cameron, H, de Groot, J, Boucher, C, Koopmans, M, van Kampen, J, Fraaij, P, van Rossum, A, Vermont, C, van der Knaap, L, Visser, E, Branger, J, Douma, R, Duijf-Van de Ven, C, Schippers, E, van Nieuwkoop, C, van IJperen, J, Geilings, J, van der Hut, G, van Burgel, N, Leyten, E, Gelinck, L, Mollema, F, Davids-Veldhuis, S, Wildenbeest, G, Heikens, E, Groeneveld, P, Bouwhuis, J, Lammers, A, Kraan, S, van Hulzen, A, Kruiper, M, van der Bliek, G, Bor, P, Bloembergen, P, Wolfagen, M, Ruijs, G, Kroon, F, de Boer, M, Scheper, H, Jolink, H, Dorama, W, van Holten, N, Claas, E, Wessels, E, den Hollander, J, El Moussaoui, R, Pogany, K, Kastelijns, M, Smit, J, Smit, E, Struik-Kalkman, D, Tearno, C, van Niekerk, T, Pontesilli, O, Lowe, S, Oude Lashof, A, Posthouwer, D, Ackens, R, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I, Havenith, T, Weijer, S, van Vonderen, M, Kampschreur, L, Faber, S, Steeman-Bouma, R, Weel, J, Kootstra, G, Delsing, C, van der Burg-Van de Plas, M, Heins, H, Kortmann, W, van Twillert, G, Renckens, R, 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P., Burgers K., Schippers J., Weijenberg-Maes B., van Loo I. H. M., Havenith T. R. A., Weijer S., van Vonderen M. G. A., Kampschreur L. M., Faber S., Steeman-Bouma R., Weel J., Kootstra G. J., Delsing C. E., van der Burg-Van de Plas M., Heins H., Kortmann W., van Twillert G., Renckens R., Ruiter-Pronk D., van Truijen-Oud F. A., Cohen Stuart J. W. T., Jansen E. R., Hoogewerf M., Rozemeijer W., van der Reijden W. A., Sinnige J. C., Brinkman K., van den Berk G. E. L., Blok W. L., Frissen P. H. J., Lettinga K. D., Schouten W. E. M., Veenstra J., Vrouenraets S. M. E., Brouwer C. J., Geerders G. F., Hoeksema K., Kleene M. J., Knapen M., van der Meche I. B., Mulder-Seeleman E., Toonen A. J. M., Wijnands S., Kwa D., van Crevel R., van Aerde K., Doferhof A. S. M., Henriet S. S. V., ter Hofstede H. J. M., Hoogerwerf J., Keuter M., Richel O., Albers M., Grintjes-Huisman K. J. T., de Haan M., Marneef M., Strik-Albers R., Rahamat-Langendoen J., Stelma F. F., Burger D., Gisolf E. H., Hassing R. J., Claassen M., ter Beest G., van Bentum P. H. M., Langebeek N., Tiemessen R., Swanink C. M. A., van Lelyveld S. F. L., Soetekouw R., van der Prijt L. M. M., van der Swaluw J., Bermon N., Jansen R., Herpers B. L., Veenendaal D., Verhagen D. W. M., Lauw F. N., van Broekhuizen M. C., van Wijk M., Bierman W. F. W., Bakker M., Kleinnijenhuis J., Kloeze E., Middel A., Scholvinck E. H., Stienstra Y., Verhage A. R., Wouthuyzen-Bakker K. M., Boonstra A., de Groot-De Jonge H., van der Meulen P. A., de Weerd D. A., Niesters H. G. M., van Leer-Buter C. C., Knoester M., Hoepelman A. I. M., Arends J. E., Barth R. E., Bruns A. H. W., Ellerbroek P. M., Mudrikova T., Oosterheert J. J., de Regt M. J. A., Schadd E. M., van Zoelen M. A. D., Aarsman K., Grifoen-Van Santen B. M. G., de Kroon I., van Rooijen C. S. A. M., van Berkel M., Schuurman R., Verduyn-Lunel F., Wensing A. M. J., Bont L. J., Geelen S. P. M., Loefen Y. G. T., Wolfs T. F. W., Nauta N., Zaheri S., Boyd A. C., Bezemer D. O., van Sighem A. I., Smit C., Hillebregt M., de Jong A., Woudstra T., Bergsma D., Meijering R., van de Sande L., Rutkens T., van der Vliet S., de Groot L., van den Akker M., Bakker Y., El Berkaoui A., Bezemer M., Bretin N., Djoechro E., Geerlinks J., Kruijne E., Lodewijk C., Lucas E., van der Meer R., Munjishvili L., Paling F., Peeck B., Ree C., Regtop R., Ruijs Y., Schoorl M., Schnorr P., Tuijn E., Veenenberg L., Witte E. C., Tuk B., Moreno S., del Amo J., Dalmau D., Navarro M. L., Gonzalez M. I., Blanco J. L., Garcia F., Rubio R., Iribarren J. A., Gutierrez F., Vidal F., Berenguer J., Gonzalez J., Sobrino P., Alejos B., Alvarez D., Jarrin I., Moreno C., Munoz-Fernandez M. A., Garcia-Merino I., Rico C. G., de la Fuente J. G., Torre A. G., Portilla J., Merino E., Reus S., Boix V., Giner L., Gadea C., Portilla I., Pampliega M., Diez M., Rodriguez J. C., Sanchez-Paya J., Podzamczer D., Imaz E. F. A., Van Den Eyncle E., Di Yacovo S., Sumoy M., Gomez J. L., Hernandez J., Aleman M. R., Alonso M. D. M., Hernandez M. I., Diaz-Flores F., Garcia D., Pelazas R., Asensi V., Valle E., Carton J. A., Perez V. E., Molina M. J. T., Garcia J. V., Carrera E. P. -C., Pulido F., Bisbal O., Matarranz M., Lagarde M., Rubio-Martin R., Hernando A., Bermejo L., Dominguez L., Arrizabalaga J., Aramburu M. J., Camino X., Rodriguez-Arrondo F., von Wichmann M. A., Tome L. P., Goenaga M. A., Bustinduy M. J., Galparsoro H. A., Ibarguren M., Aguado M., Umerez M., Masia M., Lopez C., Padilla S., Navarro A., Montolio F., Robledano C., Colome J. G., Adsuar A., Pascual R., Carlos F., Martinez M., Garcia J. L., Fernandez M., Garcia E., Muga R., Tor J., Sanvisens A., Bernaldo de Quiros Lopez J. C., Miralles P., Gutierrez I., Ramirez M., Padilla B., Gijon P., Carrero A., Aldamiz-Echevarria T., Tejerina F., Parras F. J., Balsalobre P., Diez C., Peraire J., Vilades C., Veloso S., Vargas M., Lopez-Dupla M., Olona M., Aguilar A., Sirvent J. J., Alba V., Calavia O., Montero M., Lacruz J., Blanes M., Calabuig E., Cuellar S., Lopez J., Salavert M., de la Serna I. B., Arribas J. R., Montes M. L., Pena J. M., Arribas B., Castro J. M., Zamora J., Perez I., Estebanez M., Garcia S., Diaz M., Alcariz N. S., Mingorance J., Montero D., Gonzalez A., Isabel de Jose M., de los Santos I., Sanz J., Salas A., Sarria C., Berrocal A. G., Garcia-Fraile L., Oteo J. A., Blanco J. R., Ibarra V., Metola L., Sanz M., Perez-Martinez L., Pascual A., Ramos C., Arazo P., Gil D., Jaen A., Cairo M., Irigoyen D., Jordano Q., Xercavins M., Martinez-Lacasa J., Velli P., Font R., Sanmarti M., Ibanez L., Rivero M., Casado M. I., Diaz J. A., Uriz J., Reparaz J., Irigoyen C., Arraiza M. J., Segura F., Amengual M. J., Navarro G., Sala M., Cervantes M., Pineda V., Segura V., Navarro M., Anton E., Nogueras M. M., Casado J. L., Dronda F., Moreno A., Elias M. J. P., Lopez D., Gutierrez C., Madrid N., Lamas A., Marti P., de Diaz A., Serrrano S., Donat L., Cano A., Bernal E., Munoz A., Pena A., Munoz L., Parra J., Alvarez M., Chueca N., Guillot V., Vinuesa D., Fernandez J. A., Del Romero J., Rodriguez C., Puerta T., Carrio J. C., Vera M., Ballesteros J., Domingo P., Sambeat M. A., Lamarca K., Mateo G., Gutierrez M., Fernandez I., Antela A., Losada E., Riera M., Penaranda M., Leyes M., Ribas M. A., Campins A. A., Vidal C., Gil L., Fanjul F., Marinescu C., Ribera E., Santos J., Marquez M., Viciana I., Palacios R., Gonzalez C. M., Viciana P., Leal M., Lopez-Cortes L. F., Espinosa N., Munoz J., Zubero M. Z., Baraia-Etxaburu J. M., Ibarra S., Ferrero O., Lopez de Munain J., Camara M. M., Lopez I., de la Pena M., Suarez-Garcia I., Malmierca E., Olalla J., del Arco A., de la Torre J., Prada J. L., Caracuel Z., Lopez-Lirola A. M., Lozano A. B., Fernandez E., Fernandez J. M., Martinez O. J., Vera F. J., Martinez L., Garcia J., Alcaraz B., Jimeno A., Poveda E., Pernas B., Mena A., Grandal M., Castro A., Pedreira J. D., Galera C., Albendin H., Iborra A., Campillo M. A., Vidal A., Amador C., Pasquau F., Ena J., Benito C., Fenoll V., Mohamed-Balghata M. O., Gomez M. A., Alberto de Zarraga M., Rivas M. E., Gorgolas M., Svedhem-Johansson V., Flamholc L., Gisslen M., Hejdeman B., Norgren H., and Wendahl S.
Abstract: Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods. A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results. We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions. The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control.
Published: 2020

32. The Strategic Behaviour of Underwriters in Valuing IPOs

Author: Douglas Cumming, Carol Alexander, Paleari, Stefano, Signori, Andrea, Vismara, Silvio, Andrea Signori (ORCID:0000-0002-7502-5451), Douglas Cumming, Carol Alexander, Paleari, Stefano, Signori, Andrea, Vismara, Silvio, and Andrea Signori (ORCID:0000-0002-7502-5451)
Abstract: This chapter studies whether underwriters strategically select comparable firms when valuing Initial Public Offerings (IPOs), and whether this behavior varies across industries. The idea is that the bias in the choice of comparable firms by underwriters is expected to increase when there is more discretion, and discretion is largely affected by the issuer’s industry. We first show that the peers selected by underwriters have higher valuations than those obtained from alternative selections, and a significant fraction of peers are replaced from the prospectus to post-IPO reports released by affiliated analysts. Then, we document that this behavior is crucially shaped by industry effects. Valuation bias is more pronounced among technology firms, where the discretion in the selection of peers is higher, and lower in the manufacturing industry. Also, the number of peers changed from the underwriter’s selection to that of affiliated analysts is larger in the technology industry and among more diversified firms.
Published: 2020

33. Cash holdings in family firms: CEO identity and implications for firm value

Author: Caprio, Lorenzo, Del Giudice, Alfonso, Signori, Andrea, Lorenzo Caprio (ORCID:0000-0003-0838-5630), Alfonso Del Giudice (ORCID:0000-0003-3916-7521), Andrea Signori (ORCID:0000-0002-7502-5451), Caprio, Lorenzo, Del Giudice, Alfonso, Signori, Andrea, Lorenzo Caprio (ORCID:0000-0003-0838-5630), Alfonso Del Giudice (ORCID:0000-0003-3916-7521), and Andrea Signori (ORCID:0000-0002-7502-5451)
Abstract: We investigate the cash holdings policy of family firms and examine potential value implications. Family firms hold more cash than other firms, with an average difference of 2.3% of total assets. This result is driven by firms managed by heir CEOs. While the cash holdings policy of first‐generation family firms is more sensitive to firm risk, consistent with founders’ increased risk aversion, that of later‐generation firms is more sensitive to information asymmetry and agency conflicts. Heir CEOs’ cash policies destroy value, as the marginal value of an additional Euro suffers from a 38.3‐cent discount, on average, relative to non‐family firms.
Published: 2020

34. Legal origin, financial development, and innovation: evidence from large public and private firms in the U.S. and Europe

Author: Caprio, Lorenzo, Rigamonti, Silvia, Signori, Andrea, Lorenzo Caprio (ORCID:0000-0003-0838-5630), Silvia Rigamonti (ORCID:0000-0002-5522-8366), Andrea Signori (ORCID:0000-0002-7502-5451), Caprio, Lorenzo, Rigamonti, Silvia, Signori, Andrea, Lorenzo Caprio (ORCID:0000-0003-0838-5630), Silvia Rigamonti (ORCID:0000-0002-5522-8366), and Andrea Signori (ORCID:0000-0002-7502-5451)
Abstract: This paper investigates the interplay between legal origin, financial market development, and the growth and innovation patterns of the population of large firms in U.S. and Europe. We document that common law countries (namely U.S., U.K., and Ireland) are characterized by a higher degree of stock market development and an increased propensity of firms to be publicly traded relative to Continental Europe. We also find that firms based in common law countries are more innovative, consistent with the view that market-based systems are more capable of financing intangible assets than bank-based systems. Also, these systems are effective at accelerating firm growth, as large firms in common law countries are sensibly younger and went public earlier than their Continental European peers, and this is particularly true for innovative firms.
Published: 2020

35. The effects of stricter regulation on the going public decision of small and knowledge-intensive firms

Author: Engelen, P. -J., Meoli, M., Signori, Andrea, Vismara, S., Signori A. (ORCID:0000-0002-7502-5451), Engelen, P. -J., Meoli, M., Signori, Andrea, Vismara, S., and Signori A. (ORCID:0000-0002-7502-5451)
Abstract: This paper studies the impact of increased securities regulation on the IPOs of small and high-tech, knowledge-intensive firms. We take advantage of the adoption of European SOX-like provisions, staggered at different dates across European countries, to test its influence on the going public decision. Starting from the population of European private firms during 1995–2012, we find that the likelihood of going public has decreased among small and high-tech, knowledge-intensive firms. Consistently, we document a 6% and 8.5% decrease in the industry-adjusted Tobin's Q of small and knowledge-intensive firms that go public after the regulatory change.
Published: 2020

36. Spatial patterns of microbial diversity in Fe-Mn deposits and associated sediments in the Atlantic and Pacific oceans

Author: Bergo, Natascha Menezes, Torres-Ballesteros, Adriana, Signori, Camila Negrão, Benites, Mariana, Jovane, Luigi, Murton, Bramley J., da Rocha, Ulisses Nunes, Pellizari, Vivian Helena, Bergo, Natascha Menezes, Torres-Ballesteros, Adriana, Signori, Camila Negrão, Benites, Mariana, Jovane, Luigi, Murton, Bramley J., da Rocha, Ulisses Nunes, and Pellizari, Vivian Helena
Abstract: Mining of deep-sea Fe-Mn deposits will remove crusts and nodules from the seafloor. The growth of these minerals takes millions of years, yet little is known about their microbiome. Besides being key elements of the biogeochemical cycles and essential links of food and energy to deep-sea, microbes have been identified to affect manganese oxide formation. In this study, we determined the composition and diversity of Bacteria and Archaea in deep-sea Fe-Mn crusts, nodules, and associated sediments from two areas in the Atlantic Ocean, the Tropic Seamount and the Rio Grande Rise. Samples were collected using ROV and dredge in 2016 and 2018 oceanographic campaigns, and the 16S rRNA gene was sequenced using Illumina platform. Additionally, we compared our results with microbiome data of Fe-Mn crusts, nodules, and sediments from Clarion-Clipperton Zone and Takuyo-Daigo Seamount in the Pacific Ocean. We found that Atlantic seamounts harbor an unusual and unknown Fe-Mn deposit microbiome with lower diversity and richness compared to Pacific areas. Crusts and nodules from Atlantic seamounts have unique taxa (Alteromonadales, Nitrospira, and Magnetospiraceae) and a higher abundance of potential metal-cycling bacteria, such as Betaproteobacteriales and Pseudomonadales. The microbial beta-diversity from Atlantic seamounts was clearly grouped into microhabitats according to sediments, crusts, nodules, and geochemistry. Despite the time scale of million years for these deposits to grow, a combination of environmental settings played a significant role in shaping the microbiome of crusts and nodules. Our results suggest that microbes of Fe-Mn deposits are key in biogeochemical reactions in deep-sea ecosystems. These findings demonstrate the importance of microbial community analysis in environmental baseline studies for areas within the potential of deep-sea mining.
Published: 2022

37. Ten scientific messages on risks and opportunities for life in the Antarctic

Author: Gutt, Julian, Isla, E., Xavier, J.C., Adams, B.J., Ahn, I.-Y., Cheng, C.-H. C., Colesie, C., Cummings, V.J., Griffiths, H., Hogg, I., McIntyre, T., Meiners, Klaus M., Pearce, D.A., Peck, L., Piepenburg, D., Reisinger, R.R., Saba, G.K., Schloss, I.R., Signori, C.N., Smith, C.R., Vacchi, M., Verde, C., Wall, D.H., Gutt, Julian, Isla, E., Xavier, J.C., Adams, B.J., Ahn, I.-Y., Cheng, C.-H. C., Colesie, C., Cummings, V.J., Griffiths, H., Hogg, I., McIntyre, T., Meiners, Klaus M., Pearce, D.A., Peck, L., Piepenburg, D., Reisinger, R.R., Saba, G.K., Schloss, I.R., Signori, C.N., Smith, C.R., Vacchi, M., Verde, C., and Wall, D.H.
Abstract: Initiated by the SCAR scientific research programme “Antarctic Thresholds – Ecosystem Resilience and Adaptation” (AnT-ERA, 2013-2021), 26 experts synthesized knowledge on impacts and risks of climate-change on biological processes and ecosystem functions in the Antarctic. The ten main scientific messages that emerged addressed (1) accelerating marine and terrestrial biogeochemical cycles, (2) response to ocean acidification, (3) ecological changes in climate change hot spots, (4) unexpected dynamism of marine seafloor communities, (5) biodiversity shifts, (6) low temperature limitation of protein synthesis, (7) life intrinsically linked to changing sea ice conditions, (8) pollution, (9) genetically distinct terrestrial populations under threat, and (10) newly discovered habitats. Two-thirds of the literature included in this synthesis was published between 2010 and 2020 and only one-third was published earlier. The fast mounting, recent decadal evidence indicates various Antarctic biological communities now experience climate stress, or will experience such stress in the coming decades. The responses of organisms, ecosystem functions and services to environmental changes are complex and varied. Key knowledge gaps remain and need addressing to adequately assess future prospects for life in the Antarctic.
Published: 2022

38. Unpolarized Transverse Momentum Distributions from a global fit of Drell-Yan and Semi-Inclusive Deep-Inelastic Scattering data

Author: Bacchetta, Alessandro, Bertone, Valerio, Bissolotti, Chiara, Bozzi, Giuseppe, Cerutti, Matteo, Piacenza, Fulvio, Radici, Marco, Signori, Andrea, Bacchetta, Alessandro, Bertone, Valerio, Bissolotti, Chiara, Bozzi, Giuseppe, Cerutti, Matteo, Piacenza, Fulvio, Radici, Marco, and Signori, Andrea
Abstract: We present an extraction of unpolarized transverse-momentum-dependent parton distribution and fragmentation functions based on more than two thousands data points from several experiments for two different processes: semi-inclusive deep-inelastic scattering and Drell-Yan production of lepton pairs. The baseline analysis is performed with a Monte Carlo replica method resumming large logarithms at N3LL accuracy. The resulting description of the data is very good ($\chi^2/N_{\rm dat} = 1.06$). For semi-inclusive deep-inelastic scattering, predictions for multiplicities are normalized by factors that cure the discrepancy with data introduced by higher-order perturbative corrections.
Published: 2022

39. Snowmass 2021 White Paper: Electron Ion Collider for High Energy Physics

Author: Khalek, R. Abdul, D'Alesio, U., Arratia, M., Bacchetta, A., Battaglieri, M., Begel, M., Boglione, M., Boughezal, R., Boussarie, R., Bozzi, G., Chekanov, S. V., Celiberto, F. G., Chirilli, G., Cridge, T., Cruz-Torres, R., Corliss, R., Cotton, C., Davoudiasl, H., Deshpande, A., Dong, X., Emmert, A., Fazio, S., Forte, S., Furletova, Y., Gal, C., Gwenlan, C., Guzey, V., Harland-Lang, L. A., Helenius, I., Hentschinski, M., Hobbs, T. J., Hoeche, S., Hou, T. -J., Ji, Y., Jing, X., Kelsey, M., Klasen, M., Kang, Z. -B., Kovchegov, Y. V., Kumar, K. S., Lappi, T., Lee, K., Lee, Y. -J., Li, H. -T., Li, X., Lin, H. -W., Liu, H., Liu, Z. L., Liuti, S., Lorce, C., Lunghi, E., Marcarelli, R., Magill, S., Makris, Y., Mantry, S., Melnitchouk, W., Mezrag, C., Moch, S., Moutarde, H., Mukherjee, Swagato, Murgia, F., Nachman, B., Nadolsky, P. M., Nam, J. D., Neill, D., Neill, E. T., Nocera, E., Nycz, M., Olness, F., Petriello, F., Pitonyak, D., Platzer, S., Prestel, S., Prokudin, A., Qiu, J., Radici, M., Radhakrishnan, S., Sadofyev, A., Rojo, J., Ringer, F., Salazar, F., Sato, N., Schenke, B., Schlichting, S., Schweitzer, P., Sekula, S. J., Shao, D. Y., Sherrill, N., Sichtermann, E., Signori, A., Simsek, K., Simonelli, A., Sznajder, P., Tezgin, K., Thorne, R. S., Tricoli, A., Venugopalan, R., Vladimirov, A., Vicini, A., Vitev, I., Wiegand, D., Wong, C. -P., Xie, K., Zaccheddu, M., Zhao, Y., Zhang, J., Zheng, X., Zurita, P., Khalek, R. Abdul, D'Alesio, U., Arratia, M., Bacchetta, A., Battaglieri, M., Begel, M., Boglione, M., Boughezal, R., Boussarie, R., Bozzi, G., Chekanov, S. V., Celiberto, F. G., Chirilli, G., Cridge, T., Cruz-Torres, R., Corliss, R., Cotton, C., Davoudiasl, H., Deshpande, A., Dong, X., Emmert, A., Fazio, S., Forte, S., Furletova, Y., Gal, C., Gwenlan, C., Guzey, V., Harland-Lang, L. A., Helenius, I., Hentschinski, M., Hobbs, T. J., Hoeche, S., Hou, T. -J., Ji, Y., Jing, X., Kelsey, M., Klasen, M., Kang, Z. -B., Kovchegov, Y. V., Kumar, K. S., Lappi, T., Lee, K., Lee, Y. -J., Li, H. -T., Li, X., Lin, H. -W., Liu, H., Liu, Z. L., Liuti, S., Lorce, C., Lunghi, E., Marcarelli, R., Magill, S., Makris, Y., Mantry, S., Melnitchouk, W., Mezrag, C., Moch, S., Moutarde, H., Mukherjee, Swagato, Murgia, F., Nachman, B., Nadolsky, P. M., Nam, J. D., Neill, D., Neill, E. T., Nocera, E., Nycz, M., Olness, F., Petriello, F., Pitonyak, D., Platzer, S., Prestel, S., Prokudin, A., Qiu, J., Radici, M., Radhakrishnan, S., Sadofyev, A., Rojo, J., Ringer, F., Salazar, F., Sato, N., Schenke, B., Schlichting, S., Schweitzer, P., Sekula, S. J., Shao, D. Y., Sherrill, N., Sichtermann, E., Signori, A., Simsek, K., Simonelli, A., Sznajder, P., Tezgin, K., Thorne, R. S., Tricoli, A., Venugopalan, R., Vladimirov, A., Vicini, A., Vitev, I., Wiegand, D., Wong, C. -P., Xie, K., Zaccheddu, M., Zhao, Y., Zhang, J., Zheng, X., and Zurita, P.
Abstract: Electron Ion Collider (EIC) is a particle accelerator facility planned for construction at Brookhaven National Laboratory on Long Island, New York by the United States Department of Energy. EIC will provide capabilities of colliding beams of polarized electrons with polarized beams of proton and light ions. EIC will be one of the largest and most sophisticated new accelerator facilities worldwide, and the only new large-scale accelerator facility planned for construction in the United States in the next few decades. The versatility, resolving power and intensity of EIC will present many new opportunities to address some of the crucial and fundamental open scientific questions in particle physics. This document provides an overview of the science case of EIC from the perspective of the high energy physics community., Comment: Submitted to the Proceedings of the US Community Study on the Future of Particle Physics (Snowmass 2021)
Published: 2022

40. Prognostic Impact of Bronchoalveolar Lavage Fluid Galactomannan and Aspergillus Culture Results on Survival in COVID-19 Intensive Care Unit Patients: a Post Hoc Analysis from the European Confederation of Medical Mycology (ECMM) COVID-19-Associated Pulmonary Aspergillosis Study.

Author: Giacobbe, Daniele Roberto, Hanson, Kimberly E1, Giacobbe, Daniele Roberto, Prattes, Juergen, Wauters, Joost, Dettori, Silvia, Signori, Alessio, Salmanton-García, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Klimko, Nikolay, Shadrivova, Olga, Cornely, Oliver A, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, Bassetti, Matteo, Hoenigl, Martin, ECMM-CAPA Study Group, Giacobbe, Daniele Roberto, Hanson, Kimberly E1, Giacobbe, Daniele Roberto, Prattes, Juergen, Wauters, Joost, Dettori, Silvia, Signori, Alessio, Salmanton-García, Jon, Maertens, Johan, Bourgeois, Marc, Reynders, Marijke, Rutsaert, Lynn, Van Regenmortel, Niels, Lormans, Piet, Feys, Simon, Klimko, Nikolay, Shadrivova, Olga, Cornely, Oliver A, Rautemaa-Richardson, Riina, Koehler, Philipp, Lagrou, Katrien, Bassetti, Matteo, Hoenigl, Martin, and ECMM-CAPA Study Group
Abstract: Critically ill patients with coronavirus disease 2019 (COVID-19) may develop COVID-19-associated pulmonary aspergillosis (CAPA), which impacts their chances of survival. Whether positive bronchoalveolar lavage fluid (BALF) mycological tests can be used as a survival proxy remains unknown. We conducted a post hoc analysis of a previous multicenter, multinational observational study with the aim of assessing the differential prognostic impact of BALF mycological tests, namely, positive (optical density index of ≥1.0) BALF galactomannan (GM) and positive BALF Aspergillus culture alone or in combination for critically ill patients with COVID-19. Of the 592 critically ill patients with COVID-19 enrolled in the main study, 218 were included in this post hoc analysis, as they had both test results available. CAPA was diagnosed in 56/218 patients (26%). Most cases were probable CAPA (51/56 [91%]) and fewer were proven CAPA (5/56 [9%]). In the final multivariable model adjusted for between-center heterogeneity, an independent association with 90-day mortality was observed for the combination of positive BALF GM and positive BALF Aspergillus culture in comparison with both tests negative (hazard ratio, 2.53; 95% CI confidence interval [CI], 1.28 to 5.02; P = 0.008). The other independent predictors of 90-day mortality were increasing age and active malignant disease. In conclusion, the combination of positive BALF GM and positive BALF Aspergillus culture was associated with increased 90-day mortality in critically ill patients with COVID-19. Additional study is needed to explore the possible prognostic value of other BALF markers.
Published: 2022

41. Comparison of two clinical approaches based on visual criteria for secondary caries assessments and treatment decisions in permanent posterior teeth

Author: Signori, C., Uehara, J.L.S., Romero, V.H.D., Moro, B.L.P., Braga, M.M., Mendes, F.M., Cenci, M.S., Signori, C., Uehara, J.L.S., Romero, V.H.D., Moro, B.L.P., Braga, M.M., Mendes, F.M., and Cenci, M.S.
Abstract: Item does not contain fulltext, BACKGROUND: This cross-sectional study aimed to compare two clinical approaches based on visual criteria for secondary caries assessments and treatment decisions in permanent posterior teeth. METHODS: The two clinical visual criteria tested for the assessments of restored teeth were: FDI criteria-based on the caries presence, marginal adaptation and staining criteria, adapted from the FDI (International Dental Federation) criteria and CARS criteria-"Caries Associated with Restorations or Sealants" (CARS) criteria described by the International Caries Classification and Management System. Adults were randomized according to the criteria. One calibrated examiner assessed the restorations and assigned the treatment according to the criteria. The primary outcome was replacement indication. RESULTS: A total of 185 patients were included, totalling 718 restorations. The strongest correlation founded between the methods was for the presence of caries lesions (Rho = 0.829). A moderate correlation (Rho = 0.420) was founded between the treatment decisions proposed by the CARS and by the FDI criteria. The multilevel regression analysis showed that the FDI criteria indicated five times more replacements when compared to the CARS (< 0.001). Also, using the FDI criteria restorations were 2.7 times more related to caries around restorations (p < 0.001) compared to the other criterion. CONCLUSIONS: The visual criteria used on the restoration's assessment directly influences the treatment decision to intervene or not on the restoration. The use of a minimally invasive based approach for assessing secondary caries may prevent overtreatment.
Published: 2022

42. Opportunities for precision QCD physics in hadronization at Belle II -- a snowmass whitepaper

Author: Accardi, A., Chien, Y. T., d'Enterria, D., Deshpande, A., Dilks, C., Garcia, P. A. Gutierrez, Jacobs, W. W., Krauss, F., Gomez, S. Leal, Mondal, M. Mouli, Parham, K., Ringer, F., Sanchez-Puertas, P., Schneider, S., Schnell, G., Scimemi, I., Seidl, R., Signori, A., Sjöstrand, T., Sterman, G., Vossen, A., Accardi, A., Chien, Y. T., d'Enterria, D., Deshpande, A., Dilks, C., Garcia, P. A. Gutierrez, Jacobs, W. W., Krauss, F., Gomez, S. Leal, Mondal, M. Mouli, Parham, K., Ringer, F., Sanchez-Puertas, P., Schneider, S., Schnell, G., Scimemi, I., Seidl, R., Signori, A., Sjöstrand, T., Sterman, G., and Vossen, A.
Abstract: This document presents a selection of QCD studies accessible to high-precision studies with hadronic final states in $e^+e^-$ collisions at Belle II. The exceptionally clean environment and the state-of-the-art capabilities of the Belle~II detector (including excellent particle identification and improved vertex reconstruction), coupled with an unprecedented data-set size, will make possible to carry out multiple valuable measurements of the strong interaction including hadronic contributions to the muon $(g-2)$ and the QCD coupling, as well as advanced studies of parton hadronization and dynamical quark mass generation., Comment: 58 pages, 16 figures, contribution to Snowmass 2021
Published: 2022

43. Phenomenology of gluon TMDs from $\eta_{b,c}$ production

Author: Bacchetta, Alessandro, Celiberto, Francesco Giovanni, Radici, Marco, Signori, Andrea, Bacchetta, Alessandro, Celiberto, Francesco Giovanni, Radici, Marco, and Signori, Andrea
Abstract: We present the potential of $\eta_{b,c}$ production in proton collisions to access the gluon transverse-momentum dependent parton distributions (TMDs). In particular, we explore the phenomenology of the unpolarized and linearly-polarized gluon TMDs in unpolarized collisions for different kinematic settings, and the potential of a fixed-target experiment at the LHC., Comment: 7 pages, 1 figure. Presented by F.G. Celiberto at DIS2022: XXIX International Workshop on Deep-Inelastic Scattering and Related Subjects, Santiago de Compostela, Spain, May 2-6 2022
Published: 2022

44. Spatial patterns of microbial diversity in Fe-Mn deposits and associated sediments in the Atlantic and Pacific oceans

Author: Menezes Bergo, N., Torres-Ballesteros, A., Negrão Signori, C., Benites, M., Jovane, L., Murton, B.J., Nunes da Rocha, Ulisses, Pellizari, V.H., Menezes Bergo, N., Torres-Ballesteros, A., Negrão Signori, C., Benites, M., Jovane, L., Murton, B.J., Nunes da Rocha, Ulisses, and Pellizari, V.H.
Abstract: Mining of deep-sea Fe-Mn deposits will remove crusts and nodules from the seafloor. The growth of these minerals takes millions of years, yet little is known about their microbiome. Besides being key elements of the biogeochemical cycles and essential links of food and energy to deep-sea, microbes have been identified to affect manganese oxide formation. In this study, we determined the composition and diversity of Bacteria and Archaea in deep-sea Fe-Mn crusts, nodules, and associated sediments from two areas in the Atlantic Ocean, the Tropic Seamount and the Rio Grande Rise. Samples were collected using ROV and dredge in 2016 and 2018 oceanographic campaigns, and the 16S rRNA gene was sequenced using Illumina platform. Additionally, we compared our results with microbiome data of Fe-Mn crusts, nodules, and sediments from Clarion-Clipperton Zone and Takuyo-Daigo Seamount in the Pacific Ocean. We found that Atlantic seamounts harbor an unusual and unknown Fe-Mn deposit microbiome with lower diversity and richness compared to Pacific areas. Crusts and nodules from Atlantic seamounts have unique taxa (Alteromonadales, Nitrospira, and Magnetospiraceae) and a higher abundance of potential metal-cycling bacteria, such as Betaproteobacteriales and Pseudomonadales. The microbial beta-diversity from Atlantic seamounts was clearly grouped into microhabitats according to sediments, crusts, nodules, and geochemistry. Despite the time scale of million years for these deposits to grow, a combination of environmental settings played a significant role in shaping the microbiome of crusts and nodules. Our results suggest that microbes of Fe-Mn deposits are key in biogeochemical reactions in deep-sea ecosystems. These findings demonstrate the importance of microbial community analysis in environmental baseline studies for areas within the potential of deep-sea mining.
Published: 2022

45. The day 100 score predicts moderate to severe cGVHD, transplant mortality, and survival after hematopoietic cell transplantation

Author: Metafuni, Elisabetta, Cavattoni, Irene Maria, Lamparelli, Teresa, Raiola, Anna Maria, Ghiso, Anna, Galaverna, Federica, Gualandi, Francesca, Di Grazia, Carmen, Dominietto, Alida, Varaldo, Riccardo, Signori, Alessio, Chiusolo, Patrizia, Sora', Federica, Giammarco, Sabrina, Laurenti, Luca, Sica, Simona, Angelucci, Emanuele, Bacigalupo, Andrea, Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Sora', Federica (ORCID:0000-0002-9607-5298), Laurenti, Luca (ORCID:0000-0002-8327-1396), Bacigalupo, Andrea (ORCID:0000-0002-9119-567X), Metafuni, Elisabetta, Cavattoni, Irene Maria, Lamparelli, Teresa, Raiola, Anna Maria, Ghiso, Anna, Galaverna, Federica, Gualandi, Francesca, Di Grazia, Carmen, Dominietto, Alida, Varaldo, Riccardo, Signori, Alessio, Chiusolo, Patrizia, Sora', Federica, Giammarco, Sabrina, Laurenti, Luca, Sica, Simona, Angelucci, Emanuele, Bacigalupo, Andrea, Chiusolo, Patrizia (ORCID:0000-0002-1355-1587), Sora', Federica (ORCID:0000-0002-9607-5298), Laurenti, Luca (ORCID:0000-0002-8327-1396), and Bacigalupo, Andrea (ORCID:0000-0002-9119-567X)
Abstract: The aim of this study was to develop a predictive score for moderate-severe chronic graft-versus-host disease (cGVHD) on day +100 after allogeneic stem cell transplantation (HSCT). We studied 1292 patients allografted between 1990 and 2016, alive on day +100 after transplant, without cGVHD, and with full biochemistry laboratory values available. Patients were randomly assigned to a training and a validation cohort (ratio 1:1). In the training cohort, a multivariate analysis identified 4 independent predictors of moderate-severe cGVHD: gamma-glutamyl transferase >= 75 UI/l, creatinine >= 1 mg/dl, cholinesterase <= 4576 UI/l, and albumin <= 4 g/dl. A score of 1 was assigned to each variable, producing a low (0 to 1), intermediate (2 to 3), and high (4) score. The cumulative incidence of moderate-severe cGVHD was 12%, 20%, and 52% (P<.0001) in the training cohort, and 13%, 24%, and 33% (P = .002) in the validation cohort, respectively. The 5-year cumulative incidence of transplant-related mortality (TRM) was 5%, 14%, 27% (P<.0001) and 5%, 16%, 31% (P<.0001), respectively. The 5-year survival was 64%, 57%, 54% (P = .009) and 70%, 59%, 42% (P = .0008) in the 2 cohorts, respectively. In conclusion, Day100 score predicts cGVHD, TRM, and survival and, if validated in a separate group of patients, could be considered for trials of preemptive therapy.
Published: 2022

46. Validation of the Meet-URO score in patients with metastatic renal cell carcinoma receiving first-line nivolumab and ipilimumab in the Italian Expanded Access Program

Author: Rebuzzi, S. E., Signori, A., Buti, S., Banna, G. L., Murianni, V., Damassi, A., Maruzzo, M., Giannarelli, Diana, Tortora, Giampaolo, Galli, L., Rizzo, M., De Giorgi, U., Antonuzzo, L., Bracarda, S., Cartenì, G., Atzori, Francesco, Tamberi, S., Procopio, G., Fratino, L., Lo Re, G., Santoni, M., Baldessari, C., Astone, Antonio, Calabrò, F., Brunelli, M., Porta, C., Rescigno, P., Basso, U., Fornarini, G., Giannarelli D., Tortora G. (ORCID:0000-0002-1378-4962), Atzori F., Astone A. (ORCID:0000-0001-9572-309X), Rebuzzi, S. E., Signori, A., Buti, S., Banna, G. L., Murianni, V., Damassi, A., Maruzzo, M., Giannarelli, Diana, Tortora, Giampaolo, Galli, L., Rizzo, M., De Giorgi, U., Antonuzzo, L., Bracarda, S., Cartenì, G., Atzori, Francesco, Tamberi, S., Procopio, G., Fratino, L., Lo Re, G., Santoni, M., Baldessari, C., Astone, Antonio, Calabrò, F., Brunelli, M., Porta, C., Rescigno, P., Basso, U., Fornarini, G., Giannarelli D., Tortora G. (ORCID:0000-0002-1378-4962), Atzori F., and Astone A. (ORCID:0000-0001-9572-309X)
Abstract: Background: The Meet-URO score allowed a more accurate prognostication than the International Metastatic RCC Database Consortium (IMDC) for patients with pre-treated metastatic renal cell carcinoma (mRCC) by adding the pre-treatment neutrophil-to-lymphocyte ratio and presence of bone metastases.Materials and methods: A post hoc analysis was carried out to validate the Meet-URO score on the overall survival (OS) of patients with IMDC intermediate-poor-risk mRCC treated with first-line nivolumab plus ipilimumab within the prospective Italian Expanded Access Programme (EAP). We additionally considered progression-free survival (PFS) and disease response rates. Harrell's c-index was calculated to compare the accuracy of survival prediction.Results: Overall the EAP included 306 patients, with a median follow-up of 12.2 months, median OS was not reached, 1-year OS was 66.8% and median PFS was 7.9 months. By univariable analysis, both the IMDC score and the two additional variables of the Meet-URO score were associated with either OS or PFS (P < 0.001 for all comparisons). The four Meet-URO risk groups (G) had 1-year OS of 92%, 72%, 50% and 21% for G2 (29.1% of patients), G3 (28.8%), G4 (33.0%) and G5 (9.1%), respectively. OS was significantly shorter in each consecutive G (P = 0.001 for G3, P < 0.001 for both G4 and G5 compared to G2). Similarly, Meet-URO Gs 2-5 showed decreasing median PFS and response rates. The Meet-URO score showed the highest c-index for both OS (0.73) and PFS (0.67). Limitations include the post hoc nature of this analysis and the lack of a comparative arm to assess predictive value.Conclusion: The Meet-URO score appeared to show better prognostic classification than the IMDC alone in patients with mRCC at IMDC intermediate-poor risk treated with first-line nivolumab and ipilimumab.
Published: 2022

47. ATHENA Detector Proposal -- A Totally Hermetic Electron Nucleus Apparatus proposed for IP6 at the Electron-Ion Collider

Author: ATHENA Collaboration, Adam, J., Adamczyk, L., Agrawal, N., Aidala, C., Akers, W., Alekseev, M., Allen, M. M., Ameli, F., Angerami, A., Antonioli, P., Apadula, N. J., Aprahamian, A., Armstrong, W., Arratia, M., Arrington, J. R., Asaturyan, A., Aschenauer, E. C., Augsten, K., Aune, S., Bailey, K., Baldanza, C., Bansal, M., Barbosa, F., Barion, L., Barish, K., Battaglieri, M., Bazilevsky, A., Behera, N. K., Berdnikov, V., Bernauer, J., Berriaud, C., Bhasin, A., Bhattacharya, D. S., Bielcik, J., Bielcikova, J., Bissolotti, C., Boeglin, W., Bondì, M., Borri, M., Bossu, F., Bouyjou, F., Brandenburg, J. D., Bressan, A., Brooks, M., Bueltmann, S. L., Byer, D., Caines, H., Sanchez, M. Calderon de la Barca, Calvelli, V., Camsonne, A., Cappelli, L., Capua, M., Castro, M., Cavazza, D., Cebra, D., Celentano, A., Chakaberia, I., Chan, B., Chang, W., Chartier, M., Chatterjee, C., Chen, D., Chen, J., Chen, K., Chen, Z., Chetri, H., Chiarusi, T., Chiosso, M., Chu, X., Chwastowski, J. J., Cicala, G., Cisbani, E., Cline, E., Cloet, I., Colella, D., Contalbrigo, M., Contin, G., Corliss, R., Corrales-Morales, Y., Crafts, J., Crawford, C., Cruz-Torres, R., D'Ago, D., D'Angelo, A., D'Hose, N., Dainton, J., Torre, S. Dalla, Dasgupta, S. S., Dash, S., Dashyan, N., Datta, J., Daugherity, M., De Vita, R., Deconinck, W., Defurne, M., Dehmelt, K., Del Dotto, A., Delcarro, F., Dellacasa, G., Demiroglu, Z. S., Deptuch, G. W., Desai, V., Deshpande, A., Devereaux, K., Dhillon, R., Di Salvo, R., Dilks, C., Dixit, D., Dobbs, S., Dong, X., Drachenberg, J., Drees, A., Dupre, R., Durham, M., Dzhygadlo, R., Fassi, L. El, Elia, D., Epple, E., Esha, R., Evdokimov, O., Eyser, O., Falchieri, D., Fan, W., Fantini, A., Fatemi, R., Fazio, S., Fegan, S., Filippi, A., Fox, H., Francisco, A., Freeze, A., Furletov, S., Furletova, Y., Gal, C., Gardner, S., Garg, P., Gaskell, D., Gates, K., Gericke, M. T. W., Geurts, F., Ghosh, C., Giacalone, M., Giacomini, F., Gilchrist, S., Glazier, D., Gnanvo, K., Gonella, L., Greiner, L. C., Guerrini, N., Guo, L., Gupta, A., Gupta, R., Guryn, W., He, X., Hemmick, T., Heppelmann, S., Higinbotham, D., Hoballah, M., Hoghmrtsyan, A., Hohlmann, M., Horn, T., Hornidge, D., Huang, H. Z., Hyde, C. E., Iapozzuto, P., Idzik, M., Jacak, B. V., Jadhav, M., Jain, S., Jena, C., Jentsch, A., Ji, Y., Ji, Z., Jia, J., Jones, P. G., Jones, R. W. I., Joosten, S., Joshi, S., Kabir, L., Kalicy, G., Karyan, G., Kashyap, V. K. S., Kawall, D., Ke, H., Kelsey, M., Kim, J., Kiryluk, J., Kiselev, A., Klein, S. R., Klest, H., Kochar, V., Korsch, W., Kosarzewski, L., Kotzinian, A., Krizek, F., Kumar, A., Kumar, K. S., Kumar, L., Kumar, R., Kumar, S., Kunnath, A., Kushawaha, N., Lacey, R., Lai, Y. S., Lalwani, K., Landgraf, J., Lanza, L., Lattuada, D., Lavinsky, M., Lee, J. H., Lee, S. H., Lemmon, R., Lestone, A., Lewis, N., Li, H., Li, S., Li, W., Li, X., Liang, X., Ligonzo, T., Lin, T., Liu, J., Liu, K., Liu, M., Livingston, K., Liyanage, N., Ljubicic, T., Long, O., Lukow, N., Ma, Y., Mammei, J., Mammoliti, F., Mamo, K., Mandjavidze, I., Maple, S., Marchand, D., Margotti, A., Markert, C., Markowitz, P., Marshall, T., Martin, A., Marukyan, H., Mastroserio, A., Mathew, S., Mayilyan, S., Mayri, C., McEneaney, M., Mei, Y., Meng, L., Meot, F., Metcalfe, J., Meziani, Z. -E., Mihir, P., Milton, R., Mirabella, A., Mirazita, M., Mkrtchyan, A., Mkrtchyan, H., Mohanty, B., Mondal, M., Morreale, A., Movsisyan, A., Muenstermann, D., Mukherjee, A., Camacho, C. Munoz, Murray, M. J., Mustafa, H., Myska, M., Nachman, B. P., Nagai, K., Naik, R., Naim, J. P., Nam, J., Nandi, B., Nappi, E., Nasim, Md., Neff, D., Neiret, D., Newman, P. R., Nguyen, M., Niccolai, S., Nie, M., Noferini, F., Norman, J., Noto, F., Nunes, A. S., O'Connor, T., Odyniec, G., Okorokov, V. A., Osipenko, M., Page, B., Palatchi, C., Palmer, D., Palni, P., Pandey, S., Panzieri, D., Park, S., Paschke, K., Pastore, C., Patra, R. N., Paul, A., Paul, S., Pecar, C., Peck, A., Pegg, I., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Piotrzkowski, K., Polakovic, T., Ploskon, M., Posik, M., Prasad, S., Preghenella, R., Priens, S., Prifti, E., Przybycien, M., Pujahari, P., Quintero, A., Radici, M., Radhakrishnan, S. K., Rahman, S., Rathi, S., Raue, B., Reed, R., Reimer, P., Reinhold, J., Renner, E., Rignanese, L., Ripani, M., Rizzo, A., Romanov, D., Roy, A., Rubini, N., Ruspa, M., Ruan, L., Sabatie, F., Sadhukhan, S., Sahoo, N., Sahu, P., Samuel, D., Sarkar, A., Sarsour, M., Schmidke, W., Schmookler, B., Schwarz, C., Schwiening, J., Scott, M., Sedgwick, I., Segreti, M., Sekula, S., Seto, R., Shah, N., Shahinyan, A., Sharma, D., Sharma, N., Sichtermann, E. P., Signori, A., Singh, A., Singh, B. K., Singh, S. N., Smirnov, N., Sokhan, D., Soltz, R., Sondheim, W., Spinali, S., Stacchi, F., Staszewski, R., Stepanov, P., Strazzi, S., Stroe, I. R., Sun, X., Surrow, B., Sweger, Z., Symons, T. J., Tadevosyan, V., Tang, A., Tassi, E., Teodorescu, L., Tessarotto, F., Thomas, D., Thomas, J. H., Toll, T., Tomasek, L., Torales-Acosta, F., Tribedy, P., Triloki, Tripathi, V., Trotta, R., Trzebiński, M., Trzeciak, B. A., Tsai, O., Tu, Z., Turrisi, R., Tuve, C., Ullrich, T., Urciuoli, G. M., Valentini, A., Vallarino, S., Vandenbroucke, M., Vanek, J., Vino, G., Volpe, G., Voskanyan, H., Vossen, A., Voutier, E., Wang, G., Wang, Y., Watts, D., Wickramaarachchi, N., Wilson, F., Wong, C. -P., Wu, X., Wu, Y., Xie, J., Xu, Q. -H., Xu, Z., Xu, Z. W., Yang, C., Yang, Q., Yang, Y., Ye, Z., Yi, L., Yin, Z., Yurov, M., Zachariou, N., Zhang, J., Zhang, Y., Zhang, Z., Zhao, Y., Zhao, Y. X., Zhao, Z., Zheng, L., Zurek, M., ATHENA Collaboration, Adam, J., Adamczyk, L., Agrawal, N., Aidala, C., Akers, W., Alekseev, M., Allen, M. M., Ameli, F., Angerami, A., Antonioli, P., Apadula, N. J., Aprahamian, A., Armstrong, W., Arratia, M., Arrington, J. R., Asaturyan, A., Aschenauer, E. C., Augsten, K., Aune, S., Bailey, K., Baldanza, C., Bansal, M., Barbosa, F., Barion, L., Barish, K., Battaglieri, M., Bazilevsky, A., Behera, N. K., Berdnikov, V., Bernauer, J., Berriaud, C., Bhasin, A., Bhattacharya, D. S., Bielcik, J., Bielcikova, J., Bissolotti, C., Boeglin, W., Bondì, M., Borri, M., Bossu, F., Bouyjou, F., Brandenburg, J. D., Bressan, A., Brooks, M., Bueltmann, S. L., Byer, D., Caines, H., Sanchez, M. Calderon de la Barca, Calvelli, V., Camsonne, A., Cappelli, L., Capua, M., Castro, M., Cavazza, D., Cebra, D., Celentano, A., Chakaberia, I., Chan, B., Chang, W., Chartier, M., Chatterjee, C., Chen, D., Chen, J., Chen, K., Chen, Z., Chetri, H., Chiarusi, T., Chiosso, M., Chu, X., Chwastowski, J. J., Cicala, G., Cisbani, E., Cline, E., Cloet, I., Colella, D., Contalbrigo, M., Contin, G., Corliss, R., Corrales-Morales, Y., Crafts, J., Crawford, C., Cruz-Torres, R., D'Ago, D., D'Angelo, A., D'Hose, N., Dainton, J., Torre, S. Dalla, Dasgupta, S. S., Dash, S., Dashyan, N., Datta, J., Daugherity, M., De Vita, R., Deconinck, W., Defurne, M., Dehmelt, K., Del Dotto, A., Delcarro, F., Dellacasa, G., Demiroglu, Z. S., Deptuch, G. W., Desai, V., Deshpande, A., Devereaux, K., Dhillon, R., Di Salvo, R., Dilks, C., Dixit, D., Dobbs, S., Dong, X., Drachenberg, J., Drees, A., Dupre, R., Durham, M., Dzhygadlo, R., Fassi, L. El, Elia, D., Epple, E., Esha, R., Evdokimov, O., Eyser, O., Falchieri, D., Fan, W., Fantini, A., Fatemi, R., Fazio, S., Fegan, S., Filippi, A., Fox, H., Francisco, A., Freeze, A., Furletov, S., Furletova, Y., Gal, C., Gardner, S., Garg, P., Gaskell, D., Gates, K., Gericke, M. T. W., Geurts, F., Ghosh, C., Giacalone, M., Giacomini, F., Gilchrist, S., Glazier, D., Gnanvo, K., Gonella, L., Greiner, L. C., Guerrini, N., Guo, L., Gupta, A., Gupta, R., Guryn, W., He, X., Hemmick, T., Heppelmann, S., Higinbotham, D., Hoballah, M., Hoghmrtsyan, A., Hohlmann, M., Horn, T., Hornidge, D., Huang, H. Z., Hyde, C. E., Iapozzuto, P., Idzik, M., Jacak, B. V., Jadhav, M., Jain, S., Jena, C., Jentsch, A., Ji, Y., Ji, Z., Jia, J., Jones, P. G., Jones, R. W. I., Joosten, S., Joshi, S., Kabir, L., Kalicy, G., Karyan, G., Kashyap, V. K. S., Kawall, D., Ke, H., Kelsey, M., Kim, J., Kiryluk, J., Kiselev, A., Klein, S. R., Klest, H., Kochar, V., Korsch, W., Kosarzewski, L., Kotzinian, A., Krizek, F., Kumar, A., Kumar, K. S., Kumar, L., Kumar, R., Kumar, S., Kunnath, A., Kushawaha, N., Lacey, R., Lai, Y. S., Lalwani, K., Landgraf, J., Lanza, L., Lattuada, D., Lavinsky, M., Lee, J. H., Lee, S. H., Lemmon, R., Lestone, A., Lewis, N., Li, H., Li, S., Li, W., Li, X., Liang, X., Ligonzo, T., Lin, T., Liu, J., Liu, K., Liu, M., Livingston, K., Liyanage, N., Ljubicic, T., Long, O., Lukow, N., Ma, Y., Mammei, J., Mammoliti, F., Mamo, K., Mandjavidze, I., Maple, S., Marchand, D., Margotti, A., Markert, C., Markowitz, P., Marshall, T., Martin, A., Marukyan, H., Mastroserio, A., Mathew, S., Mayilyan, S., Mayri, C., McEneaney, M., Mei, Y., Meng, L., Meot, F., Metcalfe, J., Meziani, Z. -E., Mihir, P., Milton, R., Mirabella, A., Mirazita, M., Mkrtchyan, A., Mkrtchyan, H., Mohanty, B., Mondal, M., Morreale, A., Movsisyan, A., Muenstermann, D., Mukherjee, A., Camacho, C. Munoz, Murray, M. J., Mustafa, H., Myska, M., Nachman, B. P., Nagai, K., Naik, R., Naim, J. P., Nam, J., Nandi, B., Nappi, E., Nasim, Md., Neff, D., Neiret, D., Newman, P. R., Nguyen, M., Niccolai, S., Nie, M., Noferini, F., Norman, J., Noto, F., Nunes, A. S., O'Connor, T., Odyniec, G., Okorokov, V. A., Osipenko, M., Page, B., Palatchi, C., Palmer, D., Palni, P., Pandey, S., Panzieri, D., Park, S., Paschke, K., Pastore, C., Patra, R. N., Paul, A., Paul, S., Pecar, C., Peck, A., Pegg, I., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Piotrzkowski, K., Polakovic, T., Ploskon, M., Posik, M., Prasad, S., Preghenella, R., Priens, S., Prifti, E., Przybycien, M., Pujahari, P., Quintero, A., Radici, M., Radhakrishnan, S. K., Rahman, S., Rathi, S., Raue, B., Reed, R., Reimer, P., Reinhold, J., Renner, E., Rignanese, L., Ripani, M., Rizzo, A., Romanov, D., Roy, A., Rubini, N., Ruspa, M., Ruan, L., Sabatie, F., Sadhukhan, S., Sahoo, N., Sahu, P., Samuel, D., Sarkar, A., Sarsour, M., Schmidke, W., Schmookler, B., Schwarz, C., Schwiening, J., Scott, M., Sedgwick, I., Segreti, M., Sekula, S., Seto, R., Shah, N., Shahinyan, A., Sharma, D., Sharma, N., Sichtermann, E. P., Signori, A., Singh, A., Singh, B. K., Singh, S. N., Smirnov, N., Sokhan, D., Soltz, R., Sondheim, W., Spinali, S., Stacchi, F., Staszewski, R., Stepanov, P., Strazzi, S., Stroe, I. R., Sun, X., Surrow, B., Sweger, Z., Symons, T. J., Tadevosyan, V., Tang, A., Tassi, E., Teodorescu, L., Tessarotto, F., Thomas, D., Thomas, J. H., Toll, T., Tomasek, L., Torales-Acosta, F., Tribedy, P., Triloki, Tripathi, V., Trotta, R., Trzebiński, M., Trzeciak, B. A., Tsai, O., Tu, Z., Turrisi, R., Tuve, C., Ullrich, T., Urciuoli, G. M., Valentini, A., Vallarino, S., Vandenbroucke, M., Vanek, J., Vino, G., Volpe, G., Voskanyan, H., Vossen, A., Voutier, E., Wang, G., Wang, Y., Watts, D., Wickramaarachchi, N., Wilson, F., Wong, C. -P., Wu, X., Wu, Y., Xie, J., Xu, Q. -H., Xu, Z., Xu, Z. W., Yang, C., Yang, Q., Yang, Y., Ye, Z., Yi, L., Yin, Z., Yurov, M., Zachariou, N., Zhang, J., Zhang, Y., Zhang, Z., Zhao, Y., Zhao, Y. X., Zhao, Z., Zheng, L., and Zurek, M.
Abstract: ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.
Published: 2022

48. Prenatal and perinatal risk factors for bipolar disorder: a systematic review and meta-analysis

Author: Shintani, Augusto Ossamu, Rabelo-da-Ponte, Francisco Diego, Marchionatti, Lauro Estivalete, Watts, Devon, Ferreira de Souza, Fernando, Machado, Cristiane dos Santos, Pulice, Rafaela Fernandes, Signori, Giovanna Maiolli, Luzini, Rafael Rocha, Kauer-Sant'Anna, Márcia, Passos, Ives Cavalcante, Shintani, Augusto Ossamu, Rabelo-da-Ponte, Francisco Diego, Marchionatti, Lauro Estivalete, Watts, Devon, Ferreira de Souza, Fernando, Machado, Cristiane dos Santos, Pulice, Rafaela Fernandes, Signori, Giovanna Maiolli, Luzini, Rafael Rocha, Kauer-Sant'Anna, Márcia, and Passos, Ives Cavalcante
Abstract: Background Perinatal and prenatal risk factors may be implicated in the development of bipolar disorder, but literature lacks a comprehensive account of possible associations. Methods We performed a systematic review and meta-analyses of observational studies detailing the association between prenatal and perinatal risk factors and bipolar disorder in adulthood by searching PubMed, Embase, Web of Science and Psycinfo for articles published in any language between January 1st, 1960 and September 20th, 2021. Meta-analyses were performed when risk factors were available in at least two studies. Findings Twenty seven studies were included with 18 prenatal or perinatal factors reported across the literature. Peripartum asphyxia (k = 5, OR = 1.46 [1.02; 2.11]), maternal stress during pregnancy (k = 2, OR = 12.00 [3.30; 43.59]), obstetric complications (k = 6, OR = 1.41 [1.18; 1.69]), and birth weight less than 2500g (k = 5, OR = 1.28 [1.04; 1.56]) were associated with an increased risk for bipolar disorder. Interpretation Perinatal and prenatal risk factors are implicated in the pathogenesis of bipolar disorder, supporting a role of prenatal care in preventing the condition.
Published: 2022

49. Signs and symptoms of COVID-19 in patients with multiple sclerosis

Author: Schiavetti, I., Carmisciano, L., Ponzano, M., Cordioli, C., Cocco, E., Marfia, G. A., Inglese, M., Filippi, M., Radaelli, M., Bergamaschi, R., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Scandellari, C., Cavalla, P., Pesci, I., Confalonieri, P., Perini, P., Trojano, M., Lanzillo, R., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Sormani, M. P., Abbadessa, G., Aguglia, U., Allegorico, L., Rossi Allegri, B. M., Alteno, A., Amato, M. P., Annovazzi, P., Antozzi, C., Appendino, L., Arena, S., Baione, V., Balgera, R., Barcella, V., Baroncini, D., Barrila, C., Bellacosa, A., Bellucci, G., Bergamaschi, V., Bezzini, D., Biolzi, B., Bisecco, A., Bonavita, S., Borriello, G., Bosa, C., Bosco, A., Bovis, F., Bozzali, M., Brambilla, L., Brescia Morra, V., Buccafusca, M., Bucciantini, E., Bucello, S., Buscarinu, M. C., Cabboi, M. P., Calabrese, M., Calabria, F., Caleri, F., Camilli, F., Caniatti, L. M., Cantello, R., Capra, R., Capuano, R., Carta, P., Celani, M. G., Cellerino, M., Cerqua, R., Chisari, C., Clerici, R., Clerico, M., Cola, G., Conte, A., Conti, M. Z., Cordano, C., Cordera, S., Corea, F., Correale, C., Cottone, S., Crescenzo, F., Curti, E., D'Ambrosio, A., D'Amico, E., Danni, M. C., D'Arma, A., Dattola, V., de Biase, S., De Luca, G., De Mercanti, S. F., De Mitri, P., De Stefano, N., Della Cava, F. M., Cava, M. D., Di Lemme, S., di Napoli, M., Di Sapio, A., Docimo, R., Dutto, A., Evangelista, L., Fanara, S., Fantozzi, R., Ferraro, D., Ferro, M. T., Fioretti, C., Fratta, M., Frau, J., Fronza, M., Furlan, R., Gajofatto, A., Gallo, A., Gallo, P., Gasperini, C., Ghazaryan, A., Giometto, B., Gobbin, F., Govone, F., Granella, F., Grange, E., Grasso, M. G., Grimaldi, L. M. E., Guareschi, A., Guaschino, C., Guerrieri, S., Guidetti, D., Juergenson, I. B., Iaffaldano, P., Ianniello, A., Iasevoli, L., Imperiale, D., Infante, M. T., Iodice, R., Iovino, A., Konrad, G., Landi, D., Lapucci, C., Lavorgna, L., L'Episcopo, M. R., Leva, S., Liberatore, G., Lo Re, M., Longoni, M., Lopiano, L., Lorefice, L., Lucchini, Matteo, Lus, G., Maimone, D., Malentacchi, M., Mallucci, G., Malucchi, S., Mancinelli, C. R., Mancinelli, L., Manganotti, P., Maniscalco, G. T., Mantero, V., Marangoni, S., Marastoni, D., Marinelli, F., Marti, A., Boneschi Martinelli, F., Masserano, Z. F., Matta, F., Mendozzi, L., Meucci, G., Miante, S., Miele, G., Milano, E., Mirabella, Massimiliano, Missione, R., Moccia, M., Moiola, L., Montepietra, S., Montibragadin, M., Montini, F., Motta, R., Nardone, R., Gabri Nicoletti, C., Nobile-Orazio, E., Nozzolillo, A., Onofrj, M., Orlandi, R., Palmieri, A., Paolicelli, D., Pasquali, L., Pasto, L., Pedrazzoli, E., Petracca, M., Petrone, A., Piantadosi, C., Pietroboni, A. M., Pinardi, F., Portaccio, E., Pozzato, M., Pozzilli, C., Prosperini, L., Protti, A., Ragonese, P., Rasia, S., Realmuto, S., Repice, A., Rigoni, E., Rilla, M. T., Rinaldi, F., Romano, C. M., Ronzoni, M., Rovaris, M., Ruscica, F., Sabattini, L., Salemi, G., Saraceno, L., Sartori, A., Sbragia, E., Scarano, G. I., Scarano, V., Sessa, M., Sgarito, C., Sibilia, G., Siciliano, G., Signori, A., Signoriello, E., Sinisi, L., Sireci, F., Sola, P., Solaro, C., Sotgiu, S., Sparaco, M., Stromillo, M. L., Strumia, S., Susani, E. L., Tabiadon, G., Teatini, F., Tomassini, V., Tonietti, S., Torri, V., Tortorella, C., Toscano, S., Totaro, R., Trotta, M., Turano, G., Ulivelli, M., Valentino, M., Vaula, G., Vecchio, D., Vercellino, M., Verrengia, E. P., Vianello, M., Virgilio, E., Vitetta, F., Vollaro, S., Zaffaroni, M., Zampolini, M., Zarbo, I. R., Zito, A., Zuliani, L., Lucchini M. (ORCID:0000-0002-0447-2297), Mirabella M. (ORCID:0000-0002-7783-114X), Schiavetti, I., Carmisciano, L., Ponzano, M., Cordioli, C., Cocco, E., Marfia, G. A., Inglese, M., Filippi, M., Radaelli, M., Bergamaschi, R., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Scandellari, C., Cavalla, P., Pesci, I., Confalonieri, P., Perini, P., Trojano, M., Lanzillo, R., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Sormani, M. P., Abbadessa, G., Aguglia, U., Allegorico, L., Rossi Allegri, B. M., Alteno, A., Amato, M. P., Annovazzi, P., Antozzi, C., Appendino, L., Arena, S., Baione, V., Balgera, R., Barcella, V., Baroncini, D., Barrila, C., Bellacosa, A., Bellucci, G., Bergamaschi, V., Bezzini, D., Biolzi, B., Bisecco, A., Bonavita, S., Borriello, G., Bosa, C., Bosco, A., Bovis, F., Bozzali, M., Brambilla, L., Brescia Morra, V., Buccafusca, M., Bucciantini, E., Bucello, S., Buscarinu, M. C., Cabboi, M. P., Calabrese, M., Calabria, F., Caleri, F., Camilli, F., Caniatti, L. M., Cantello, R., Capra, R., Capuano, R., Carta, P., Celani, M. G., Cellerino, M., Cerqua, R., Chisari, C., Clerici, R., Clerico, M., Cola, G., Conte, A., Conti, M. Z., Cordano, C., Cordera, S., Corea, F., Correale, C., Cottone, S., Crescenzo, F., Curti, E., D'Ambrosio, A., D'Amico, E., Danni, M. C., D'Arma, A., Dattola, V., de Biase, S., De Luca, G., De Mercanti, S. F., De Mitri, P., De Stefano, N., Della Cava, F. M., Cava, M. D., Di Lemme, S., di Napoli, M., Di Sapio, A., Docimo, R., Dutto, A., Evangelista, L., Fanara, S., Fantozzi, R., Ferraro, D., Ferro, M. T., Fioretti, C., Fratta, M., Frau, J., Fronza, M., Furlan, R., Gajofatto, A., Gallo, A., Gallo, P., Gasperini, C., Ghazaryan, A., Giometto, B., Gobbin, F., Govone, F., Granella, F., Grange, E., Grasso, M. G., Grimaldi, L. M. E., Guareschi, A., Guaschino, C., Guerrieri, S., Guidetti, D., Juergenson, I. B., Iaffaldano, P., Ianniello, A., Iasevoli, L., Imperiale, D., Infante, M. T., Iodice, R., Iovino, A., Konrad, G., Landi, D., Lapucci, C., Lavorgna, L., L'Episcopo, M. R., Leva, S., Liberatore, G., Lo Re, M., Longoni, M., Lopiano, L., Lorefice, L., Lucchini, Matteo, Lus, G., Maimone, D., Malentacchi, M., Mallucci, G., Malucchi, S., Mancinelli, C. R., Mancinelli, L., Manganotti, P., Maniscalco, G. T., Mantero, V., Marangoni, S., Marastoni, D., Marinelli, F., Marti, A., Boneschi Martinelli, F., Masserano, Z. F., Matta, F., Mendozzi, L., Meucci, G., Miante, S., Miele, G., Milano, E., Mirabella, Massimiliano, Missione, R., Moccia, M., Moiola, L., Montepietra, S., Montibragadin, M., Montini, F., Motta, R., Nardone, R., Gabri Nicoletti, C., Nobile-Orazio, E., Nozzolillo, A., Onofrj, M., Orlandi, R., Palmieri, A., Paolicelli, D., Pasquali, L., Pasto, L., Pedrazzoli, E., Petracca, M., Petrone, A., Piantadosi, C., Pietroboni, A. M., Pinardi, F., Portaccio, E., Pozzato, M., Pozzilli, C., Prosperini, L., Protti, A., Ragonese, P., Rasia, S., Realmuto, S., Repice, A., Rigoni, E., Rilla, M. T., Rinaldi, F., Romano, C. M., Ronzoni, M., Rovaris, M., Ruscica, F., Sabattini, L., Salemi, G., Saraceno, L., Sartori, A., Sbragia, E., Scarano, G. I., Scarano, V., Sessa, M., Sgarito, C., Sibilia, G., Siciliano, G., Signori, A., Signoriello, E., Sinisi, L., Sireci, F., Sola, P., Solaro, C., Sotgiu, S., Sparaco, M., Stromillo, M. L., Strumia, S., Susani, E. L., Tabiadon, G., Teatini, F., Tomassini, V., Tonietti, S., Torri, V., Tortorella, C., Toscano, S., Totaro, R., Trotta, M., Turano, G., Ulivelli, M., Valentino, M., Vaula, G., Vecchio, D., Vercellino, M., Verrengia, E. P., Vianello, M., Virgilio, E., Vitetta, F., Vollaro, S., Zaffaroni, M., Zampolini, M., Zarbo, I. R., Zito, A., Zuliani, L., Lucchini M. (ORCID:0000-0002-0447-2297), and Mirabella M. (ORCID:0000-0002-7783-114X)
Abstract: Background and purpose Clinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation. Method Logistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number. Results From March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p < 0.001). All cases should be referred to variants up to Delta. Conclusion Several factors along with the choice of specific therapeutic approaches might have a different impact on the occurrence of some COVID-19 symptoms.
Published: 2022

50. The effect of two clinical criteria in the assessment of caries lesions around restorations in children (CARDEC-03):study protocol for a diagnostic randomized clinical trial [version 2; peer review: 2 approved]

Author: Moro, Bruna Lorena Pereira, Signori, Cácia, Freitas, Raiza Dias, Pontes, Laura Regina Antunes, Lenzi, Tathiane Larissa, Tedesco, Tamara Kerber, Raggio, Daniela Prócida, Braga, Mariana Minatel, Ekstrand, Kim Rud, Cenci, Maximiliano Sérgio, Mendes, Fausto Medeiros, Moro, Bruna Lorena Pereira, Signori, Cácia, Freitas, Raiza Dias, Pontes, Laura Regina Antunes, Lenzi, Tathiane Larissa, Tedesco, Tamara Kerber, Raggio, Daniela Prócida, Braga, Mariana Minatel, Ekstrand, Kim Rud, Cenci, Maximiliano Sérgio, and Mendes, Fausto Medeiros
Abstract: Introduction: The detection of caries lesions around restoration can be challenging. Therefore, the use of some criteria has been proposed in order to give more objectivity to the diagnosis process. Two of them are the International Dental Federation (FDI) and the Caries Associated with Restorations and Sealants (CARS) criteria. Bothmethods have a different approach to caries, and it is not possible to know which one of them is the best to use in clinical practice to assess restorations in children. Thus, the present protocol aims to evaluate the effect of the use of the FDI and CARS criteria in the assessment of caries lesions around restorations in primary teeth on outcomes related to oral health in children and costs resulting from the assessments. Methods and analysis: A total of 626 restorations of children from three to 10 years were randomly assessed and are being treated following the FDI criteria (FDI group) or CARS criteria (CARS group). Participants will be followed-up after six, 12, 18, and 24 months. The primary outcome will be the need for a new intervention in the evaluated restorations. This outcome consists of several components, and each of these events will be analyzed separately as secondary outcomes. The changes in children’s oral health-related quality of life and the cost of the restoration dental treatments will also be analyzed as secondary outcomes. The methods will be compared using the Cox regression model with shared frailty. A significance level of 5% will be adopted for all statistical analyses. Discussion: This will be the first randomized clinical study carried out regarding the detection of caries lesions around restorations in primary teeth. Trial registration: The study underwent registration in Clinicaltrials.gov (NCT03520309) on 9 May 2018
Published: 2022

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