1. Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA
- Author
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Moore, E., Grifoni, A., Weiskopf, D., Schulten, V., Arlehamn, C.S.L., Angelo, M., Pham, J., Leary, S., Sidney, J., Broide, D., Frazier, A., Phillips, E., Mallal, S., Mack, S.J., Sette, A., Moore, E., Grifoni, A., Weiskopf, D., Schulten, V., Arlehamn, C.S.L., Angelo, M., Pham, J., Leary, S., Sidney, J., Broide, D., Frazier, A., Phillips, E., Mallal, S., Mack, S.J., and Sette, A.
- Abstract
DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the class I allele A∗02:01. Genotype data will be available in the Allele Frequencies Net Database (AFND 3562).
- Published
- 2018