14 results on '"Schulman, Joshua M"'
Search Results
2. Post-zoster fibroelastolytic papulosis: an example of Wolf isotopic response
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Shawa, Harrison, Shawa, Harrison, Opene, Caroline, Schulman, Joshua M., Sood, Apra, Shawa, Harrison, Shawa, Harrison, Opene, Caroline, Schulman, Joshua M., and Sood, Apra
- Abstract
Wolf isotopic response describes the onset of a new dermatosis at the site of a previous, healed dermatosis, which is usually a herpes zoster infection. Fibroelastolytic papulosis is a poorly understood elastolytic condition defined by a loss of elastic fibers specific to the papillary dermis. The present report describes a case of fibroelastolytic papulosis with onset following herpes zoster infection. This association provides new evidence for an immunopathogenic origin for fibroelastolytic papulosis and further supports current theories of the pathogenesis of Wolf isotopic response. more...
- Published
- 2023
Catalog
3. Granuloma annulare-like eruption in chronic lymphocytic leukemia
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Hadian, Yasmin, Hadian, Yasmin, Beroukhim, Kourosh, Fung, Maxwell A, Schulman, Joshua M, Hadian, Yasmin, Hadian, Yasmin, Beroukhim, Kourosh, Fung, Maxwell A, and Schulman, Joshua M
- Abstract
We report a patient with new-onset ulcerated granuloma annulare with concomitant involvement of B-cell leukemia. A granuloma annulare-like eruption with concomitant B cell chronic lymphocytic leukemia involvement in the skin is extremely rare, as only three cases have been previously reported in the literature to our knowledge. Given the rarity of ulceration in conventional granuloma annulare, it is possible this finding may serve as a diagnostic clue for underlying malignancy. more...
- Published
- 2020
4. Granuloma annulare-like eruption in chronic lymphocytic leukemia
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Hadian, Yasmin, Hadian, Yasmin, Beroukhim, Kourosh, Fung, Maxwell A, Schulman, Joshua M, Hadian, Yasmin, Hadian, Yasmin, Beroukhim, Kourosh, Fung, Maxwell A, and Schulman, Joshua M
- Abstract
We report a patient with new-onset ulcerated granuloma annulare with concomitant involvement of B-cell leukemia. A granuloma annulare-like eruption with concomitant B cell chronic lymphocytic leukemia involvement in the skin is extremely rare, as only three cases have been previously reported in the literature to our knowledge. Given the rarity of ulceration in conventional granuloma annulare, it is possible this finding may serve as a diagnostic clue for underlying malignancy. more...
- Published
- 2020
5. Safety of light emitting diode-red light on human skin: Two randomized controlled trials.
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Jagdeo, Jared, Jagdeo, Jared, Nguyen, Julie K, Ho, Derek, Wang, Erica B, Austin, Evan, Mamalis, Andrew, Kaur, Ramanjot, Kraeva, Ekaterina, Schulman, Joshua M, Li, Chin-Shang, Hwang, Samuel T, Wun, Ted, Maverakis, Emanual, Isseroff, R Rivkah, Jagdeo, Jared, Jagdeo, Jared, Nguyen, Julie K, Ho, Derek, Wang, Erica B, Austin, Evan, Mamalis, Andrew, Kaur, Ramanjot, Kraeva, Ekaterina, Schulman, Joshua M, Li, Chin-Shang, Hwang, Samuel T, Wun, Ted, Maverakis, Emanual, and Isseroff, R Rivkah more...
- Abstract
Therapeutic applications of light emitting diode-red light (LED-RL) are expanding, yet data on its clinical effects are lacking. Our goal was to evaluate the safety of high fluence LED-RL (≥160 J/cm2 ). In two phase I, single-blind, dose escalation, randomized controlled trials, healthy subjects received LED-RL or mock irradiation to the forearm thrice weekly for 3 weeks at fluences of 160-640 J/cm2 for all skin types (STARS 1, n = 60) and at 480-640 J/cm2 for non-Hispanic Caucasians (STARS 2, n = 55). The primary outcome was the incidence of adverse events (AEs). The maximum tolerated dose was the highest fluence that did not elicit predefined AEs. Dose-limiting AEs, including blistering and prolonged erythema, occurred at 480 J/cm2 in STARS 1 (n = 1) and 640 J/cm2 in STARS 2 (n = 2). AEs of transient erythema and hyperpigmentation were mild. No serious AEs occurred. We determined that LED-RL is safe up to 320 J/cm2 for skin of color and 480 J/cm2 for non-Hispanic Caucasian individuals. LED-RL may exert differential cutaneous effects depending on race and ethnicity, with darker skin being more photosensitive. These findings may guide future studies to evaluate the efficacy of LED-RL for the treatment of various diseases. more...
- Published
- 2020
6. Radiation induced lichen planus - an uncommon side effect
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Hadian, Yasmin, Hadian, Yasmin, Chen, Yi-Chun, Eastham, David V, Schulman, Joshua M, Sood, Apra, Hadian, Yasmin, Hadian, Yasmin, Chen, Yi-Chun, Eastham, David V, Schulman, Joshua M, and Sood, Apra
- Abstract
Cutaneous lichen planus is classically characterized by violaceous, pruritic, planar papules and plaques, most commonly affecting the extremities. Lichen planus following radiation therapy is extremely rare and lichen planus following radiation therapy for prostate carcinoma has not been previously reported in the literature. We report a 66-year-old man who presented to the dermatology clinic with a symmetric pruritic eruption affecting the pelvic and gluteal region within two months of radiation therapy targeting the prostate and pelvic lymph nodes for prostate adenocarcinoma. The patient did not have a prior history of lichen planus. Physical examination demonstrated well demarcated, violaceous papules and plaques in a circumferential band-like distribution on the bilateral gluteal, lumbosacral, and pelvic region. In addition, he had a few discrete lesions on the calves and dorsal feet. Punch biopsy revealed an acanthotic epidermis with "saw-tooth" rete ridges and a lichenoid inflammatory infiltrate. A diagnosis of hypertrophic lichen planus was made, reinforcing the importance for clinicians to recognize radiation therapy as a risk factor for developing lichen planus despite no prior history of lichen planus. more...
- Published
- 2019
7. Radiation induced lichen planus - an uncommon side effect
- Author
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Hadian, Yasmin, Hadian, Yasmin, Chen, Yi-Chun, Eastham, David V, Schulman, Joshua M, Sood, Apra, Hadian, Yasmin, Hadian, Yasmin, Chen, Yi-Chun, Eastham, David V, Schulman, Joshua M, and Sood, Apra
- Abstract
Cutaneous lichen planus is classically characterized by violaceous, pruritic, planar papules and plaques, most commonly affecting the extremities. Lichen planus following radiation therapy is extremely rare and lichen planus following radiation therapy for prostate carcinoma has not been previously reported in the literature. We report a 66-year-old man who presented to the dermatology clinic with a symmetric pruritic eruption affecting the pelvic and gluteal region within two months of radiation therapy targeting the prostate and pelvic lymph nodes for prostate adenocarcinoma. The patient did not have a prior history of lichen planus. Physical examination demonstrated well demarcated, violaceous papules and plaques in a circumferential band-like distribution on the bilateral gluteal, lumbosacral, and pelvic region. In addition, he had a few discrete lesions on the calves and dorsal feet. Punch biopsy revealed an acanthotic epidermis with "saw-tooth" rete ridges and a lichenoid inflammatory infiltrate. A diagnosis of hypertrophic lichen planus was made, reinforcing the importance for clinicians to recognize radiation therapy as a risk factor for developing lichen planus despite no prior history of lichen planus. more...
- Published
- 2019
8. The distribution of cutaneous metastases correlates with local immunologic milieu.
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Schulman, Joshua M, Schulman, Joshua M, Pauli, Mariela L, Neuhaus, Isaac M, Sanchez Rodriguez, Roberto, Taravati, Keyon, Shin, Uk Sok, McCalmont, Timothy H, Rosenblum, Michael D, Schulman, Joshua M, Schulman, Joshua M, Pauli, Mariela L, Neuhaus, Isaac M, Sanchez Rodriguez, Roberto, Taravati, Keyon, Shin, Uk Sok, McCalmont, Timothy H, and Rosenblum, Michael D more...
- Abstract
BackgroundMetastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood.ObjectiveWe aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites.MethodsWe retrospectively identified all biopsy specimens of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal-appearing skin samples (n = 140), we measured the density of regulatory T cells, CD4(+) effector T cells, and CD8(+) T cells by flow cytometry.ResultsPer unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of regulatory T cells and a lower proportion of CD8(+) T cells (P < .05).LimitationsImmunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study.ConclusionThe distribution of cutaneous metastases follows the distribution of regulatory and effector T cells in skin. Further studies are required to prove a mechanistic association between local immunologic factors and the development of cutaneous metastases. more...
- Published
- 2016
9. Absence of peripheral blood chimerism in graft-vs-host disease following orthotopic liver transplantation: case report and review of the literature.
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Schulman, Joshua M, Schulman, Joshua M, Yoon, Christina, Schwarz, Jennifer, Vagefi, Parsia A, Mully, Thaddeus W, Shinkai, Kanade, Schulman, Joshua M, Schulman, Joshua M, Yoon, Christina, Schwarz, Jennifer, Vagefi, Parsia A, Mully, Thaddeus W, and Shinkai, Kanade more...
- Abstract
BackgroundGraft-vs-host disease (GVHD) is a rare and often fatal complication of orthotopic liver transplantation (OLT). The skin is frequently involved early in disease progression, but clinical and histopathological features may be nonspecific, presenting a diagnostic challenge. While the detection of peripheral blood chimerism has been proposed as a diagnostic criterion for post-OLT GVHD, it is not known whether peripheral blood chimerism is an absolute requirement for the diagnosis.Materials and methodsWe report a case of a 57-year-old man who developed post-OLT GVHD with cutaneous, enteric, and bone marrow involvement. We also review the epidemiology, pathogenesis, clinical presentation, histopathology, molecular diagnostic techniques, and treatment of GVHD following liver transplantation.ResultsIn our patient, analysis of the peripheral blood by short-tandem repeat polymerase chain reaction did not detect circulating donor lymphocytes. Donor lymphocytes were detected in the buccal mucosa, however, confirming the diagnosis. A review of chimerism patterns in 63 previously published cases of post-OLT GVHD reveals that this is the first reported case in which chimerism was absent in the peripheral blood but present in another site.ConclusionsPeripheral blood chimerism may be absent in cases of post-OLT GVHD. A combination of clinical, histopathological, and molecular features is therefore required to make this challenging diagnosis. more...
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- 2014
10. Fluoroscopy-induced radionecrosis
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Tchanque-Fossuo, Catherine N, Tchanque-Fossuo, Catherine N, Kamangar, Faranak, Ho, Baran, Chang, Shurong, Dahle, Sara E, Schulman, Joshua M, Isseroff, R Rivkah, Tchanque-Fossuo, Catherine N, Tchanque-Fossuo, Catherine N, Kamangar, Faranak, Ho, Baran, Chang, Shurong, Dahle, Sara E, Schulman, Joshua M, and Isseroff, R Rivkah more...
- Abstract
Complications from radiation exposure during fluoroscopic guidance of cardiac catheterization may occur. With repeated procedures, the risk for cutaneous injuries increases. Herein, we describe a 59-year-old man with extensive coronary artery disease, who had undergone multiple revascularization procedures and developed a non-healing ulcer on his left inferior scapula. The patient’s medical history, physical exam findings, and histopathology gave clues to a case of radiation-induced dermatitis and necrosis. more...
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- 2016
11. Fluoroscopy-induced radionecrosis
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Tchanque-Fossuo, Catherine N, Tchanque-Fossuo, Catherine N, Kamangar, Faranak, Ho, Baran, Chang, Shurong, Dahle, Sara E, Schulman, Joshua M, Isseroff, R Rivkah, Tchanque-Fossuo, Catherine N, Tchanque-Fossuo, Catherine N, Kamangar, Faranak, Ho, Baran, Chang, Shurong, Dahle, Sara E, Schulman, Joshua M, and Isseroff, R Rivkah more...
- Abstract
Complications from radiation exposure during fluoroscopic guidance of cardiac catheterization may occur. With repeated procedures, the risk for cutaneous injuries increases. Herein, we describe a 59-year-old man with extensive coronary artery disease, who had undergone multiple revascularization procedures and developed a non-healing ulcer on his left inferior scapula. The patient’s medical history, physical exam findings, and histopathology gave clues to a case of radiation-induced dermatitis and necrosis. more...
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- 2016
12. A case of hair re-pigmentation from a scalp melanoma
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Oza, Vikash S, Oza, Vikash S, Schulman, Joshua M, Mully, Thaddeus W, Ortiz, Susana, Oza, Vikash S, Oza, Vikash S, Schulman, Joshua M, Mully, Thaddeus W, and Ortiz, Susana
- Abstract
Hair re-pigmentation in adults is a rare phenomenon. We describe a 58-year-old woman who developed hair re-pigmentation on her vertex scalp as a marker of underlying melanoma. Histopathology revealed a nodular melanoma that was surrounding but not invading follicular epithelium. To our knowledge, there have only been 4 other previously published cases describing hair re-pigmentation in the setting of scalp melanoma. Focal hair re-pigmentation in adults should prompt a thorough evaluation for an underlying melanoma. more...
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- 2015
13. A case of hair re-pigmentation from a scalp melanoma
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Oza, Vikash S, Oza, Vikash S, Schulman, Joshua M, Mully, Thaddeus W, Ortiz, Susana, Oza, Vikash S, Oza, Vikash S, Schulman, Joshua M, Mully, Thaddeus W, and Ortiz, Susana
- Abstract
Hair re-pigmentation in adults is a rare phenomenon. We describe a 58-year-old woman who developed hair re-pigmentation on her vertex scalp as a marker of underlying melanoma. Histopathology revealed a nodular melanoma that was surrounding but not invading follicular epithelium. To our knowledge, there have only been 4 other previously published cases describing hair re-pigmentation in the setting of scalp melanoma. Focal hair re-pigmentation in adults should prompt a thorough evaluation for an underlying melanoma. more...
- Published
- 2015
14. Atypical MRI features in soft-tissue arteriovenous malformation: a novel imaging appearance with radiologic-pathologic correlation.
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Patel, Anand S, Patel, Anand S, Schulman, Joshua M, Ruben, Beth S, Hoffman, William Y, Dowd, Christopher F, Frieden, Ilona J, Hess, Christopher P, Patel, Anand S, Patel, Anand S, Schulman, Joshua M, Ruben, Beth S, Hoffman, William Y, Dowd, Christopher F, Frieden, Ilona J, and Hess, Christopher P more...
- Abstract
BackgroundThe absence of a discrete mass, surrounding signal abnormality and solid enhancement are imaging features that have traditionally been used to differentiate soft-tissue arteriovenous malformations from vascular tumors on MRI. We have observed that these findings are not uncommon in arteriovenous malformations, which may lead to misdiagnosis or inappropriate treatment.ObjectiveTo estimate the frequency of atypical MRI features in soft-tissue arteriovenous malformations and assess their relationship to lesion size, location, tissue type involved and vascular architecture.Materials and methodsMedical records, MRI and histopathology were reviewed in consecutive patients with soft-tissue arteriovenous malformations in a multidisciplinary vascular anomalies clinic. Arteriovenous malformations were divided into those with and without atypical MRI findings (perilesional T2 signal abnormality, enhancement and/or a soft-tissue mass). Lesion location, size, tissue involved and vascular architecture were also compared between groups. Tissue stains were reviewed in available biopsy or resection specimens to assess relationships between MRI findings and histopathology.ResultsThirty patients with treatment-naïve arteriovenous malformations were included. Fifteen lesions demonstrated atypical MRI. There was no difference in age, gender, lesion size or involved body part between the groups. However, more than half of the atypical lesions demonstrated multicompartmental involvement, and tiny intralesional flow voids were more common in atypical arteriovenous malformations. Histopathology also differed in atypical cases, showing densely packed endothelial cells with connective tissue architectural distortion and edema.ConclusionArteriovenous malformations may exhibit features of a vascular tumor on MRI, particularly when multicompartmental and/or containing tiny internal vessels. These features are important to consider in suspected fast-flow vascular malformations and may h more...
- Published
- 2015
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