1. Tumor stabilization induced by T-cell recruitment fluctuations
- Author
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Bashkirtseva, I., Ryashko, L., López, Á. G., Seoane, J. M., Sanjuán, M. A. F., Bashkirtseva, I., Ryashko, L., López, Á. G., Seoane, J. M., and Sanjuán, M. A. F.
- Abstract
The influence of random fluctuations on the recruitment of effector cells towards a tumor is studied by means of a stochastic mathematical model. Aggressively growing tumors are confronted against varying intensities of the cell-mediated immune response for which chaotic and periodic oscillations coexist together with stable tumor dynamics. A thorough parametric analysis of the noise-induced transition from this oscillatory regime to complete tumor dominance is carried out. A hysteresis phenomenon is uncovered, which stabilizes the tumor at its carrying capacity and drives the healthy and the immune cell populations to their extinction. Furthermore, it is shown that near a crisis bifurcation, such transitions occur under weak noise intensities. Finally, the corresponding noise-induced chaos-order transformation is analyzed and discussed in detail. © World Scientific Publishing Company
- Published
- 2020