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Jennifer Robertson is Professor of Anthropology and the History of Art at the University of Michigan, Ann Arbor. She has a non-budgeted appointment in the Department of Women's Studies and in the School of Art and Design. She is also a faculty associate in the Anthropology/History Program. Robertson is a former director and member of the Center for Japanese Studies, and an associate in the Science, Society and Technology Program and Center for Middle Eastern and North African Studies. Robertson is the originator and general editor of Colonialisms, a book series from the University of California Press that explores the historical realities, current significance, and future ramifications of imperialist practices with origins and boundaries outside of "the West." She is also a co-editor of Critical Asian Studies (http://criticalasianstudies.org/). Her six books and dozens of articles and chapters address a wide spectrum of subjects ranging from the 17th century to the present, including nativist and social rectification movements, agrarianism, sex and gender systems and ideologies, mass and popular culture, nostalgia and internationalization, urbanism, the place of Japan in American Anthropology, sexuality and suicide, theater and performance, votive and folk art, imperialism and colonialism, and eugenics and bioethics. She offers graduate and undergraduate courses on anthropology's history, theories and methods; non-western colonialisms; art and anthropology; image-based ethnography; the politics and practice of ethnography; mass and popular culture; genes, genealogies and identities; ethnic diversity in Japan; sex, gender and sexuality in Japan; and Japanese culture and society, among others. Robertson is currently writing and editing articles and books on the cultural history of Japanese colonialism; eugenics, bioethics, and ideologies of "blood" in Japan and Israel; the genre of war art; and humanoid robots and cyberculture in Japan and elsewhere. Although her prim

Matrix metalloproteinases (MMPs) have been suggested as therapeutic targets in cancer treatment, but broad-spectrum MMP inhibitors have failed in clinical trials. Recent data suggest that several MMPs including MMP-9 exert both pro- and antitumorigenic properties. This is also the case of the natural inhibitors of MMPs, tissue inhibitor of metalloproteinases (TIMPs). The inhibitor of MMP-9 is TIMP-1, and high levels of this enzyme have been associated with decreased survival in breast cancer. Inflammation is one hallmark of cancer progression, and MMPs/TIMPs may be involved in the local immune regulation. We investigated the role of MMP-9/TIMP-1 in regulating innate antitumor immunity in breast cancer. Breast cancers were established in nude mice and treated with intratumoral injections of adenoviruses carrying the human TIMP-1 or MMP-9 gene (AdMMP-9). In vivo microdialysis for sampling of cancer cell-derived (human) and stroma-derived (murine) proteins, immunostainings, as well as cell cultures were performed. We report a dose-dependent decrease of tumor growth and angiogenesis after AdMMP-9 treatment. In addition to increased generation of endostatin, AdMMP-9 promoted an antitumor immune response by inducing massive neutrophil infiltration. Neutrophil depletion prior to gene transfer abolished the therapeutic effects of AdMMP-9. Additionally, AdMMP-9 activated tumor-infiltrating macrophages into a tumor-inhibiting phenotype both in vivo and in vitro. AdMMP-9 also inhibited tumor growth in immune-competent mice bearing breast cancers. Adenoviruses carrying the human TIMP-1 gene had no effect on tumor growth or the immune response. Our novel data identify MMP-9 as a potent player in modulating the innate immune response into antitumor activities.

Matrix metalloproteinases (MMPs) have been suggested as therapeutic targets in cancer treatment, but broad-spectrum MMP inhibitors have failed in clinical trials. Recent data suggest that several MMPs including MMP-9 exert both pro-and antitumorigenic properties. This is also the case of the natural inhibitors of MMPs, tissue inhibitor of metalloproteinases (TIMPs). The inhibitor of MMP-9 is TIMP-1, and high levels of this enzyme have been associated with decreased survival in breast cancer. Inflammation is one hallmark of cancer progression, and MMPs/TIMPs may be involved in the local immune regulation. We investigated the role of MMP-9/TIMP-1 in regulating innate antitumor immunity in breast cancer. Breast cancers were established in nude mice and treated with intratumoral injections of adenoviruses carrying the human TIMP-1 or MMP-9 gene (AdMMP-9). In vivo microdialysis for sampling of cancer cell-derived (human) and stroma-derived (murine) proteins, immunostainings, as well as cell cultures were performed. We report a dose-dependent decrease of tumor growth and angiogenesis after AdMMP-9 treatment. In addition to increased generation of endostatin, AdMMP-9 promoted an antitumor immune response by inducing massive neutrophil infiltration. Neutrophil depletion prior to gene transfer abolished the therapeutic effects of AdMMP-9. Additionally, AdMMP-9 activated tumor-infiltrating macrophages into a tumor-inhibiting phenotype both in vivo and in vitro. AdMMP-9 also inhibited tumor growth in immune-competent mice bearing breast cancers. Adenoviruses carrying the human TIMP-1 gene had no effect on tumor growth or the immune response. Our novel data identify MMP-9 as a potent player in modulating the innate immune response into antitumor activities. The Journal of Immunology, 2013, 190: 4420-4430., Funding Agencies|Swedish Cancer Society|2009/799|Swedish Research Council|2010-3458|Research Funds of Linkoping University Hospital

2 x Jacquards completed during an International residency in Florence, Italy, 2008 and not previously exhibited.

Quadruple layered woven textile, inventive multi layered weave technique, fine merino wool, silk, differential shrinkage, different patterns on each face.

Supplementary warp woven textile, fine merino wool, silk. Inventive multi-layered weave technique, corrugated structure.

Double layered woven textile, fine merino wool, differential shrinkage. Inventive multi-layered weave technique, morphed patterns, woven on computerised 32 shaft dobby loom.

Supplementary warp corrugated woven textile, silk, yak, merino wool. Inventive multi-layered weave technique, corrugated structure.

Double layered woven textile, fine merino wool, silk. Inventive multi-layered weave technique, morphed patterns, woven on computerised 32 shaft dobby loom.

Quadruple layered woven textile, fine merino wool, silk, different patterns on each face. Inventive multi-layered weave technique.

Double layered woven textile, fine merino wool. Inventive multi-layered weave technique, morphed patterns, woven on 32 shaft computerised dobby loom.

Quadruple layered woven textile, fine merino wool, silk, differential shrinkage. Inventive multi-layered weave technique, different patterns on each face.

Supplementary warp woven textile, silk, fine merino wool. Inventive multi-layered weave technique, corrugated structure.

Quadruple layered woven textile, fine merino wool, silk, differential shrinkage. Inventive multi-layered weave technique, different woven patterns on each face.

Supplementary warp woven textile, silk, merino wool, alpaca. Inventive multi-layered weave technique, corrugated structure.

Supplementary warp woven textile, fine merino wool, silk. Inventive multi-layered weave technique, corrugated structure.

Quadruple layered woven textile, fine merino wool, silk, differential shrinkage. Inventive multi layered weave technique.

Quadruple layered woven textile, fine merino wool, silk, differential shrinkage. Inventive weave technique, different patterns on each face.

Double layered woven textile, fine merino wool. Inventive multi-layered weave/pattern technique, morphed images, woven on 32 shaft computerised dobby loom.

Solo focus exhibition Featured one work not exhibited before and was funded by Australia Council New Work Established Grant 2010. Pink Clouds, @ 110cm x 150cm, hand woven sculpted translucent gauze, fine merino wool, silk, nylon.

The Making of a Slow Journey, 2010, woven fine Australian merino wool, silk and monofilament. Exhibition touring nationally until 2013.

Passing 1, 2 and 3, 2010 starched linen, stainless steel and french foil threads, pressed, cut and folded; handwoven in one piece with woven imagery on a 32 shaft computerised loom

Solo exhibition of hand-woven textiles including: - silk/nylon heat-shrunk series - fine wool/silk/nylon heat-shrunk series - glow in the dark photo-luminescent series - triple cloths (three layered weaves) 12 works from this exhibition later shown at Narek Galleries, Tanja, NSW, 26/11/2010-3/1/2011 - quadruple cloths (four layered weaves)

Solo exhibition of hand-woven textiles: - fine wool/silk/nylon heat-shrunk series - silk/nylon heat-shrunk series Of 36 works total, 24 were being exhibited for the first time.

Group Exhibition, Textiles

Matrix metalloproteinases (MMP) are important regulators of angiogenesis and tumor progression by degradation of extracellular matrix. Clinical trials using MMP inhibitors have failed and recent studies suggest that MMPs may in contrast suppress tumor growth. It is not known, however, if MMPs or their inhibitors, tissue inhibitor of metalloproteinases (TIMP), can be used as therapy of established cancer. Here, adenovirus vectors carrying the human genes for MMP-9, TIMP-1, or empty controls were injected intratumorally in breast cancers established in mice supplemented with estradiol and treated with tamoxifen. Microdialysis was used to quantify MMP activity and sampling of endostatin and vascular endothelial growth factor (VEGF) in situ. We show that AdMMP-9 increased MMP activity in vivo, decreased tumor growth rate, and decreased microvessel area significantly. AdMMP-9 therapy resulted in significantly increased levels of endostatin in vivo, whereas VEGF levels were unaffected. As previously shown, tamoxifen exposure by itself increased MMP activity in all treatment groups. Moreover, the combined therapy with AdMMP-9 and tamoxifen further reduced tumor growth and increased the endostatin levels compared with either treatment alone. Gene transfer of TIMP-1 had no effects on tumor progression and counteracted the therapeutic effect of tamoxifen in our breast cancer model. This is the first report showing that overexpression of MMP-9 results in increased generation of antiangiogenic fragments, decreased angiogenesis, and therapeutic effects of established breast cancer.

Polymeric materials are increasingly being used in diverse, very demanding applications. Either pre- or post- application environments may require exposures to conditions hostile to the polymer's integrity. Frequently, these demanding conditions result in degradation of the polymer and subsequent decreases in desirable properties. Clearly then, a methodology to predict important properties, such as Tg, molecular weight, and tensile strength, from knowledge of the environmental history of a polymeric-based specimen is beneficial. The current study focuses on bisphenol A polycarbonate and tracks changes in the properties of this material as a function of the degree of degradation, t. For the purposes of the present research, the environmental effects have been limited to those associated with elevated temperature, although the methodology is general. This t parameter is a product of the kinetic rate constant, k, found from isothermal kinetics, and the time of degradation, t. Elucidation of t has been linked to measurement of the molecular weight distribution which in turn can be related to various properties to yield predictive relationships for these properties. Only the thermal history of the polymer and its initial properties are required for the model. This technique is not limited to a specific polymer or even to thermal degradation. As long as the kinetics of the process can be mathematically modeled, this approach should apply to a host of other situations, providing property prediction simply from knowledge of the material history. The research seeks to better understand the thermal degradation of polycarbonate. Kinetics of the process was explored, and the chemical mechanisms were examined. A key part of the project was the determination of the molecular weights and molecular weight distributions at each level of degradation. Furthermore, mechanical stress-strain properties, glass transition temperatures, and melt viscosities were also measured. This informat

Electronic access restricted; authentication may be required, American Council of Learned Societies History E-Book Project, (heb) heb04082.0001.001, http://hdl.handle.net/2027/heb.04082, Permission must be received for any subsequent distribution in print or electronically. Please contact info@hebook.org for more information.

Electronic access restricted; authentication may be required, American Council of Learned Societies History E-Book Project, (heb) heb04082.0001.001, http://hdl.handle.net/2027/heb.04082, Permission must be received for any subsequent distribution in print or electronically. Please contact info@hebook.org for more information.