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Objectives: The aims of this study are to determine the progression rate of Bosniak IIF cysts, the malignancy rates of complex renal cysts in patients undergoing surgery and explore the influence of multi-disciplinary team conference (MDT) on re-classification of Bosniak cysts. Materials and Methods: All CT scans from January 2010 to 2017 were pooled into a database. Initially, 167 patients were identified with possible Bosniak IIF, III or IV cysts. Patients with follow up of less than 24 months, without progression or regression were excluded. Results: Thirty-one (18.6%) cysts of the initial 167 cysts were either up or downgraded at a MDT. Twenty-six of the 31 cysts were up or downgraded at the primary MDT, 13 cysts (50%) were downgraded, five cysts (19.2%) were upgraded and eight cysts (30.8%) were re-classified as solid tumors. Of those 19/26 (73.1%) were primary interpreted by a periphery radiologist and re-classified centrally. The last five patients 5/120 cysts (4.2%) were re-classified during follow up. 116 patients with a total of 120 cysts met the inclusion criteria, 79 (65.8%) Bosniak IIF, 28 (23.3%) Bosniak III and 13 (10.8%) Bosniak IV cysts represented. Median follow up of Bosniak IIF cysts were 46 months. One Bosniak IIF cyst progressed to a solid tumor at 15 months from diagnosis, progression rate 1.3%. Histopathology was papillary renal cell carcinoma. Malignancy rates of Bosniak III and IV cysts were 50% and 78%, respectively. Conclusion: Multi-disciplinary team conference may have an important role in correct classification of Bosniak cysts. Trial registration: None.

61 year old male with rapid establishment of bilateral venous thrombosis and multiorgan failure., Varón de 61 años con trombosis venosa bilateral de rápida instauración y fracaso multiorgánico.

Резюме. У статті наведені результати діагностичного алгоритму та впровадження у практику малоінвазивних урологічних операцій при кістах та пухлинах нирок у порівнянні з даними відкритих урологічних операцій. Описана методика виконання ендовідеохірургічних операцій з використанням лапароскопічного та ретроперитонеального доступу. Показані клінічні переваги малоінвазивних методик., Резюме. В статье приведены результаты диагностического алгоритма и внедрение в практику малоинвазивных урологических операций при кистах и опухолях почек по сравнению с данными открытых урологических операций. Описана методика выполнения эндовидеохирургических операций с использованием лапароскопического и ретроперитонеального доступа. Показаны клинические преимущества малоинвазивных методик., In the article the results of the diagnostic algorithm and implementation in practice of low-invasive urologic operations in patients with renal cysts and tumors in comparison with the data of open urological operations were shown. The methods of performance of endovideosurgical operations with laparoscopic and retroperitoneal approach were described.. Low-invasive methods advantages were shown.

Nous rapportons le cas d’une patiente porteuse d’un adénocarcinome pulmonaireALK positif, qui développe, 17 mois après le début de son traitement par crizotinib, des kystesrénaux complexes bilatéraux. La mise au point permet de conclure à la responsabilité du médicamentanti-tumoral. Une régression des kystes est notée après 1 mois d’arrêt du crizotinib. Cecas illustre les toxicités particulières et peu connues des molécules innovantes dans la prise encharge des cancers bronchiques, SCOPUS: ar.j, info:eu-repo/semantics/published

SCOPUS: le.j, info:eu-repo/semantics/published

Objective: To test the hypothesis that there is an association between simple renal cysts and arterial blood pressure (BP). Patients and methods: The study comprised a review of the case-notes of 115 patients (mean age 67.7 years, range 31-91) in whom renal cyst(s) was an incidental ultrasonographic finding, and 115 age- and sex-matched control patients. The notes were reviewed without knowledge of the origin or treatment. Results: The systolic and diastolic BP were significantly higher in patients with a cyst(s) than in control patients (P = 0.031 and P = 0.0034; mean difference 6.9 mmHg and 5.0 mmHg, respectively). In those aged 30-70 years, the presence of one or more simple renal cysts increased the risk of having a diastolic BP ≤ 95 mmHg from seven in 58 to 17 in 58 patients (P = 0.038). Conclusion: The association between simple renal cysts and higher arterial BP probably arises from underlying renal disease causing both. Occasionally it is possible that renal ischaemia caused by cyst expansion, and therefore increased renin release, generates the elevation in BP. If so, methods to identify such cysts should be developed.

Objective: To test the hypothesis that there is an association between simple renal cysts and arterial blood pressure (BP). Patients and methods: The study comprised a review of the case-notes of 115 patients (mean age 67.7 years, range 31-91) in whom renal cyst(s) was an incidental ultrasonographic finding, and 115 age- and sex-matched control patients. The notes were reviewed without knowledge of the origin or treatment. Results: The systolic and diastolic BP were significantly higher in patients with a cyst(s) than in control patients (P = 0.031 and P = 0.0034; mean difference 6.9 mmHg and 5.0 mmHg, respectively). In those aged 30-70 years, the presence of one or more simple renal cysts increased the risk of having a diastolic BP ≤ 95 mmHg from seven in 58 to 17 in 58 patients (P = 0.038). Conclusion: The association between simple renal cysts and higher arterial BP probably arises from underlying renal disease causing both. Occasionally it is possible that renal ischaemia caused by cyst expansion, and therefore increased renin release, generates the elevation in BP. If so, methods to identify such cysts should be developed.