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311 results on '"Postma, Dirkje"'

1. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

Author: Sakornsakolpat, Phuwanat, Prokopenko, Dmitry, Lamontagne, Maxime, Reeve, Nicola F., Guyatt, Anna L., Jackson, Victoria E., Shrine, Nick, Qiao, Dandi, Bartz, Traci M., Kim, Deog Kyeom, Lee, Mi Kyeong, Latourelle, Jeanne C., Li, Xingnan, Morrow, Jarrett D., Obeidat, Ma'en, Wyss, Annah B., Bakke, Per, Barr, R. Graham, Beaty, Terri H., Belinsky, Steven A., Brusselle, Guy G., Crapo, James D., de Jong, Kim, DeMeo, Dawn L., Fingerlin, Tasha E., Gharib, Sina A., Gulsvik, Amund, Hall, Ian P., Hokanson, John E., Kim, Woo Jin, Lomas, David A., London, Stephanie J., Meyers, Deborah A., O'Connor, George T., Rennard, Stephen, I, Schwartz, David A., Sliwinski, Pawel, Sparrow, David, Strachan, David P., Tal-Singer, Ruth, Tesfaigzi, Yohannes, Vestbo, Jorgen, Vonk, Judith M., Yim, Jae-Joon, Zhou, Xiaobo, Bosse, Yohan, Manichaikul, Ani, Lahousse, Lies, Silverman, Edwin K., Boezen, H. Marike, Wain, Louise, V, Tobin, Martin D., Hobbs, Brian D., Cho, Michael H., Batini, Chiara, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E., Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimaki, Terho, Ewert, Ralf, Gieger, Christian, Homuth, Georg, Joshi, Peter K., Langenberg, Claudia, Lind, Lars, Luan, Jianan, Mahajan, Anubha, Murray, Alison, Porteous, David J., Rawal, Rajesh, Smith, Blair H., Timmers, Paul R. H. J., Raitakari, Olli T., Kahonen, Mika, Polasek, Ozren, Gyllensten, Ulf B., Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L., Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Hayward, Caroline, Morris, Andrew P., Agusti, Alvar, Anderson, Wayne, Bakerly, Nawar, Bals, Robert, Barnes, Kathleen C., Bleecker, Eugene R., Bowler, Russell, Brightling, Christopher, de Bruijne, Marleen, Castaldi, Peterj, Celli, Bartolome, Coxson, Harvey O., Crystal, Ron, de Jong, Pim, Dirksen, Asger, Dy, Jennifer, Foreman, Marilyn, Garcia-Aymerich, Judith, Gevenois, Pierre, Ghosh, Soumitra, Gietema, Hester, Hansel, Nadia, Hersh, Craig P., Hoffman, Eric, Kalsheker, Noor, Kauczor, Hans-Ulrich, Laitinen, Tarja, Lambrechts, Diether, Litonjua, Augusto A., Loth, Daan W., Lutz, Sharon M., Lynch, David, MacNee, William, McDonald, Merry-Lynn, Newell, John D., Nordestgaard, Borge G., Oh, Yeon-Mok, Pare, Peter D., Pistolesi, Massimo, Postma, Dirkje S., Puhan, Milo, Regan, Elizabeth, Rich, Stephen S., Seo, Joon Beom, Short, Andrea, Stoel, Berend, Sverzellati, Nicola, ter Riet, Gerben, Van Beek, Edwin J. R., Van Ginneken, Bram, Vogelmeier, Claus F., Wanner, Adam, Washko, George, Wauters, Els, Wouters, Emiel F. M., Young, Robert P., Zeigler-Heitbrock, Loems, Sakornsakolpat, Phuwanat, Prokopenko, Dmitry, Lamontagne, Maxime, Reeve, Nicola F., Guyatt, Anna L., Jackson, Victoria E., Shrine, Nick, Qiao, Dandi, Bartz, Traci M., Kim, Deog Kyeom, Lee, Mi Kyeong, Latourelle, Jeanne C., Li, Xingnan, Morrow, Jarrett D., Obeidat, Ma'en, Wyss, Annah B., Bakke, Per, Barr, R. Graham, Beaty, Terri H., Belinsky, Steven A., Brusselle, Guy G., Crapo, James D., de Jong, Kim, DeMeo, Dawn L., Fingerlin, Tasha E., Gharib, Sina A., Gulsvik, Amund, Hall, Ian P., Hokanson, John E., Kim, Woo Jin, Lomas, David A., London, Stephanie J., Meyers, Deborah A., O'Connor, George T., Rennard, Stephen, I, Schwartz, David A., Sliwinski, Pawel, Sparrow, David, Strachan, David P., Tal-Singer, Ruth, Tesfaigzi, Yohannes, Vestbo, Jorgen, Vonk, Judith M., Yim, Jae-Joon, Zhou, Xiaobo, Bosse, Yohan, Manichaikul, Ani, Lahousse, Lies, Silverman, Edwin K., Boezen, H. Marike, Wain, Louise, V, Tobin, Martin D., Hobbs, Brian D., Cho, Michael H., Batini, Chiara, Zhao, Jing Hua, Wielscher, Matthias, Weiss, Stefan, Kentistou, Katherine A., Cook, James P., Hui, Jennie, Karrasch, Stefan, Imboden, Medea, Harris, Sarah E., Marten, Jonathan, Enroth, Stefan, Kerr, Shona M., Surakka, Ida, Vitart, Veronique, Lehtimaki, Terho, Ewert, Ralf, Gieger, Christian, Homuth, Georg, Joshi, Peter K., Langenberg, Claudia, Lind, Lars, Luan, Jianan, Mahajan, Anubha, Murray, Alison, Porteous, David J., Rawal, Rajesh, Smith, Blair H., Timmers, Paul R. H. J., Raitakari, Olli T., Kahonen, Mika, Polasek, Ozren, Gyllensten, Ulf B., Rudan, Igor, Deary, Ian J., Probst-Hensch, Nicole M., Schulz, Holger, James, Alan L., Wilson, James F., Stubbe, Beate, Zeggini, Eleftheria, Jarvelin, Marjo-Riitta, Wareham, Nick, Hayward, Caroline, Morris, Andrew P., Agusti, Alvar, Anderson, Wayne, Bakerly, Nawar, Bals, Robert, Barnes, Kathleen C., Bleecker, Eugene R., Bowler, Russell, Brightling, Christopher, de Bruijne, Marleen, Castaldi, Peterj, Celli, Bartolome, Coxson, Harvey O., Crystal, Ron, de Jong, Pim, Dirksen, Asger, Dy, Jennifer, Foreman, Marilyn, Garcia-Aymerich, Judith, Gevenois, Pierre, Ghosh, Soumitra, Gietema, Hester, Hansel, Nadia, Hersh, Craig P., Hoffman, Eric, Kalsheker, Noor, Kauczor, Hans-Ulrich, Laitinen, Tarja, Lambrechts, Diether, Litonjua, Augusto A., Loth, Daan W., Lutz, Sharon M., Lynch, David, MacNee, William, McDonald, Merry-Lynn, Newell, John D., Nordestgaard, Borge G., Oh, Yeon-Mok, Pare, Peter D., Pistolesi, Massimo, Postma, Dirkje S., Puhan, Milo, Regan, Elizabeth, Rich, Stephen S., Seo, Joon Beom, Short, Andrea, Stoel, Berend, Sverzellati, Nicola, ter Riet, Gerben, Van Beek, Edwin J. R., Van Ginneken, Bram, Vogelmeier, Claus F., Wanner, Adam, Washko, George, Wauters, Els, Wouters, Emiel F. M., Young, Robert P., and Zeigler-Heitbrock, Loems
Abstract: Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed a genome-wide association study in 35,735 cases and 222,076 controls from the UK Biobank and additional studies from the International COPD Genetics Consortium. We identified 82 loci associated with P < 5 x 10-8; 47 of these were previously described in association with either COPD or population-based measures of lung function. Of the remaining 35 new loci, 13 were associated with lung function in 79,055 individuals from the SpiroMeta consortium. Using gene expression and regulation data, we identified functional enrichment of COPD risk loci in lung tissue, smooth muscle, and several lung cell types. We found 14 COPD loci shared with either asthma or pulmonary fibrosis. COPD genetic risk loci clustered into groups based on associations with quantitative imaging features and comorbidities. Our analyses provide further support for the genetic susceptibility and heterogeneity of COPD.
Published: 2019
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2. Genetic and epigenetic regulation of YKL-40 in childhood

Author: Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, Koppelman, Gerard H, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, and Koppelman, Gerard H
Abstract: BACKGROUND: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3-like 1 [CHI3L1]) and are increased in patients with several diseases, including asthma. Epigenetic regulation of circulating YKL-40 early in life is unknown.OBJECTIVE: We sought to determine (1) whether methylation levels at CHI3L1 CpG sites mediate the association of CHI3L1 single nucleotide polymorphisms (SNPs) with YKL-40 levels in the blood and (2) whether these biomarkers (CHI3L1 SNPs, methylation profiles, and YKL-40 levels) are associated with asthma in early childhood.METHODS: We used data from up to 2405 participants from the Spanish Infancia y Medio Ambiente; the Swedish Barn/Children, Allergy, Milieu, Stockholm, Epidemiological survey; and the Dutch Prevention and Incidence of Asthma and Mite Allergy birth cohorts. Associations between 68 CHI3L1 SNPs, methylation levels at 14 CHI3L1 CpG sites in whole-blood DNA, and circulating YKL-40 levels at 4 years of age were tested by using correlation analysis, multivariable regression, and mediation analysis. Each of these biomarkers was also tested for association with asthma at 4 years of age by using multivariable logistic regression.RESULTS: YKL-40 levels were significantly associated with 7 SNPs and with methylation at 5 CpG sites. Consistent associations between these 7 SNPs (particularly rs10399931 and rs4950928) and 5 CpG sites were observed. Alleles linked to lower YKL-40 levels were associated with higher methylation levels. Participants with high YKL-40 levels (defined as the highest YKL-40 tertile) had increased odds for asthma compared with subjects with low YKL-40 levels (meta-analyzed adjusted odds ratio, 1.90 [95% CI, 1.08-3.36]). In contrast, neither SNPs nor methylation levels at CpG sites in CHI3L1 were associated with asthma.CONCLUSIONS: The effects of CHI3L1 genetic variation on circulating YKL-40 levels are partly mediated by
Published: 2018

3. Occupational exposure to pesticides is associated with differential DNA methylation.

Author: van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, Biobank-based Integrative Omics Study Consortium, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, and Biobank-based Integrative Omics Study Consortium
Abstract: OBJECTIVES: Occupational pesticide exposure is associated with a wide range of diseases, including lung diseases, but it is largely unknown how pesticides influence airway disease pathogenesis. A potential mechanism might be through epigenetic mechanisms, like DNA methylation. Therefore, we assessed associations between occupational exposure to pesticides and genome-wide DNA methylation sites. METHODS: 1561 subjects of LifeLines were included with either no (n=1392), low (n=108) or high (n=61) exposure to any type of pesticides (estimated based on current or last held job). Blood DNA methylation levels were measured using Illumina 450K arrays. Associations between pesticide exposure and 420 938 methylation sites (CpGs) were assessed using robust linear regression adjusted for appropriate confounders. In addition, we performed genome-wide stratified and interaction analyses by gender, smoking and airway obstruction status, and assessed associations between gene expression and methylation for genome-wide significant CpGs (n=2802). RESULTS: In total for all analyses, high pesticide exposure was genome-wide significantly (false discovery rate P
Published: 2018

4. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author: Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, Nicolae, Dan L., Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.
Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Published: 2018
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5. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author: Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, Nicolae, Dan L., Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.
Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Published: 2018

6. Occupational exposure to pesticides is associated with differential DNA methylation.

Author: One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, Biobank-based Integrative Omics Study Consortium, One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, and Biobank-based Integrative Omics Study Consortium
Published: 2018

7. Genetic and epigenetic regulation of YKL-40 in childhood

Author: One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, and Koppelman, Gerard H
Published: 2018

8. Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

Author: One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, Vonk, Judith M, One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, and Vonk, Judith M
Published: 2018

9. Occupational exposure to pesticides is associated with differential DNA methylation.

Author: One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, Biobank-based Integrative Omics Study Consortium, One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, and Biobank-based Integrative Omics Study Consortium
Published: 2018

10. Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

Author: One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, Vonk, Judith M, One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, and Vonk, Judith M
Published: 2018

11. Genetic and epigenetic regulation of YKL-40 in childhood

Author: One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, and Koppelman, Gerard H
Published: 2018

12. Genetic and epigenetic regulation of YKL-40 in childhood

Author: One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, Koppelman, Gerard H, One Health Chemisch, dIRAS RA-2, Guerra, Stefano, Melén, Erik, Sunyer, Jordi, Xu, Cheng-Jian, Lavi, Iris, Benet, Marta, Bustamante, Mariona, Carsin, Anne-Elie, Dobaño, Carlota, Guxens, Mònica, Tischer, Christina, Vrijheid, Martine, Kull, Inger, Bergström, Anna, Kumar, Ashish, Söderhäll, Cilla, Gehring, Ulrike, Dijkstra, Dorieke J, van der Vlies, Pieter, Wickman, Magnus, Bousquet, Jean, Postma, Dirkje S, Anto, Josep M, and Koppelman, Gerard H
Published: 2018

13. Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study

Author: One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, Vonk, Judith M, One Health Chemisch, dIRAS RA-2, de F C Lichtenfels, Ana Julia, van der Plaat, Diana A, de Jong, Kim, van Diemen, Cleo C, Postma, Dirkje S, Nedeljkovic, Ivana, van Duijn, Cornelia M, Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K, Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P, Brunekreef, Bert, Boezen, H Marike, and Vonk, Judith M
Published: 2018

14. Occupational exposure to pesticides is associated with differential DNA methylation.

Author: One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, Biobank-based Integrative Omics Study Consortium, One Health Chemisch, dIRAS RA-2, van der Plaat, Diana A, de Jong, Kim, de Vries, Maaike, van Diemen, Cleo C, Nedeljkovic, Ivana, Amin, Najaf, Kromhout, Hans, Vermeulen, Roel, Postma, Dirkje S, van Duijn, Cornelia M, Boezen, H. Marike, Vonk, Judith M, and Biobank-based Integrative Omics Study Consortium
Published: 2018

15. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

Author: Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, Nicolae, Dan L., Demenais, Florence, Margaritte-Jeannin, Patricia, Barnes, Kathleen C., Cookson, William O. C., Altmueller, Janine, Ang, Wei, Barr, R. Graham, Beaty, Terri H., Becker, Allan B., Beilby, John, Bisgaard, Hans, Bjornsdottir, Unnur Steina, Bleecker, Eugene, Bonnelykke, Klaus, Boomsma, Dorret I., Bouzigon, Emmanuelle, Brightling, Christopher E., Brossard, Myriam, Brusselle, Guy G., Burchard, Esteban, Burkart, Kristin M., Bush, Andrew, Chan-Yeung, Moira, Chung, Kian Fan, Alves, Alexessander Couto, Curtin, John A., Custovic, Adnan, Daley, Denise, de Jongste, Johan C., Del-Rio-Navarro, Blanca E., Donohue, Kathleen M., Duijts, Liesbeth, Eng, Celeste, Eriksson, Johan G., Farrall, Martin, Fedorova, Yuliya, Feenstra, Bjarke, Ferreira, Manuel A., Freidin, Maxim B., Gajdos, Zofia, Gauderman, Jim, Gehring, Ulrike, Geller, Frank, Genuneit, Jon, Gharib, Sina A., Gilliland, Frank, Granell, Raquel, Graves, Penelope E., Gudbjartsson, Daniel F., Haahtela, Tari, Heckbert, Susan R., Heederik, Dick, Heinrich, Joachim, Heliovaara, Markku, Henderson, John, Himes, Blanca E., Hirose, Hiroshi, Hirschhorn, Joel N., Hofman, Albert, Holt, Patrick, Hottenga, Jouke, Hudson, Thomas J., Hui, Jennie, Imboden, Medea, Ivanov, Vladimir, Jaddoe, Vincent W. V., James, Alan, Janson, Christer, Jarvelin, Marjo-Riitta, Jarvis, Deborah, Jones, Graham, Jonsdottir, Ingileif, Jousilahti, Pekka, Kabesch, Michael, Kahonen, Mika, Kantor, David B., Karunas, Alexandra S., Khusnutdinova, Elza, Koppelman, Gerard H., Kozyrskyj, Anita L., Kreiner, Eskil, Kubo, Michiaki, Kumar, Rajesh, Kumar, Ashish, Kuokkanen, Mikko, Lahousse, Lies, Laitinen, Tarja, Laprise, Catherine, Lathrop, Mark, Lau, Susanne, Lee, Young-Ae, Lehtimaki, Terho, Letort, Sebastien, Levin, Albert M., Li, Guo, Liang, Liming, Loehr, Laura R., London, Stephanie J., Loth, Daan W., Manichaikul, Ani, Marenholz, Ingo, Martinez, Fernando J., Matheson, Melanie C., Mathias, Rasika A., Matsumoto, Kenji, Mbarek, Hamdi, McArdle, Wendy L., Melbye, Mads, Melen, Erik, Meyers, Deborah, Michel, Sven, Mohamdi, Hamida, Musk, Arthur W., Myers, Rachel A., Nieuwenhuis, Maartje A. E., Noguchi, Emiko, O'Connor, George T., Ogorodova, Ludmila M., Palmer, Cameron D., Palotie, Aarno, Park, Julie E., Pennell, Craig E., Pershagen, Goran, Polonikov, Alexey, Postma, Dirkje S., Probst-Hensch, Nicole, Puzyrev, Valery P., Raby, Benjamin A., Raitakari, Olli T., Ramasamy, Adaikalavan, Rich, Stephen S., Robertson, Colin F., Romieu, Isabelle, Salam, Muhammad T., Salomaa, Veikko, Schlunssen, Vivi, Scott, Robert, Selivanova, Polina A., Sigsgaard, Torben, Simpson, Angela, Siroux, Valerie, Smith, Lewis J., Solodilova, Maria, Standl, Marie, Stefansson, Kari, Strachan, David P., Stricker, Bruno H., Takahashi, Atsushi, Thompson, Philip J., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiesler, Carla M. T., Torgerson, Dara G., Tsunoda, Tatsuhiko, Uitterlinden, Andre G., van der Valk, Ralf J. P., Vaysse, Amaury, Vedantam, Sailaja, von Berg, Andrea, von Mutius, Erika, Vonk, Judith M., Waage, Johannes, Wareham, Nick J., Weiss, Scott T., White, Wendy B., Wickman, Magnus, Widen, Elisabeth, Willemsen, Gonneke, Williams, L. Keoki, Wouters, Inge M., Yang, James J., Zhao, Jing Hua, Moffatt, Miriam F., Ober, Carole, and Nicolae, Dan L.
Abstract: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.
Published: 2018

16. The emerging landscape of dynamic DNA methylation in early childhood

Author: Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, Koppelman, Gerard H, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, and Koppelman, Gerard H
Abstract: BACKGROUND: DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood.RESULTS: By analysing 538 paired DNA blood samples from children at birth and at 4-5 years old and 726 paired samples from children at 4 and 8 years old from four European birth cohorts using the Illumina Infinium Human Methylation 450 k chip, we have identified 14,150 consistent age-differential methylation sites (a-DMSs) at epigenome-wide significance of p < 1.14 × 10-7. Genes with an increase in age-differential methylation were enriched in pathways related to 'development', and were more often located in bivalent transcription start site (TSS) regions, which can silence or activate expression of developmental genes. Genes with a decrease in age-differential methylation were involved in cell signalling, and enriched on H3K27ac, which can predict developmental state. Maternal smoking tended to decrease methylation levels at the identified da-DMSs. We also found 101 a-DMSs (0.71%) that were regulated by genetic variants using cis-differential Methylation Quantitative Trait Locus (cis-dMeQTL) mapping. Moreover, a-DMS-associated genes during early development were significantly more likely to be linked with disease.CONCLUSION: Our study provides new insights into the dynamic epigenetic landscape of the first 8 years of life.
Published: 2017

17. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

Author: Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, Melen, Erik, Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, and Melen, Erik
Abstract: BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations between exposure to air pollution, using nitrogen dioxide (NO2) as marker, and epigenome-wide cord blood DNA methylation. METHODS: We meta-analyzed the associations between NO2 exposure at residential addresses during pregnancy and cord blood DNA methylation (Illumina 450K) in four European and North American studies (n = 1,508) with subsequent look-up analyses in children ages 4 (n = 733) and 8 (n = 786) years. Additionally, we applied a literature-based candidate approach for antioxidant and anti-inflammatory genes. To assess influence of exposure at the transcriptomics level, we related mRNA expression in blood cells to NO2 exposure in 4- (n = 111) and 16-year-olds (n = 239). RESULTS: We found epigenome-wide significant associations [false discovery rate (FDR) p < 0.05] between maternal NO2 exposure during pregnancy and DNA methylation in newborns for 3 CpG sites in mitochondria-related genes: cg12283362 (LONP1), cg24172570 (3.8 kbp upstream of HIBADH), and cg08973675 (SLC25A28). The associations with cg08973675 methylation were also significant in the older children. Further analysis of antioxidant and anti-inflammatory genes revealed differentially methylated CpGs in CAT and TPO in newborns (FDR p < 0.05). NO2 exposure at the time of biosampling in childhood had a significant impact on CAT and TPO expression. CONCLUSIONS: NO2 exposure during pregnancy was associated with differential offspring DNA methylation in mitochondria-related genes. Exposure to NO2 was also linked to differential methylation as well as expression of genes involved in antioxidant defense pathways. Citation: Gruzieva O, Xu CJ, Breton CV, Annesi-Maesano I, Antó JM, Auffray C, Ballereau S, Bellander T, Bousquet J, Bustamante M, Charles MA, de Kluizenaar Y, den De
Published: 2017

18. Pubertal Timing and Cardiometabolic Markers at Age 16 Years

Author: Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S, Gehring, Ulrike, Smit, Henriëtte A, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S, Gehring, Ulrike, and Smit, Henriëtte A
Abstract: OBJECTIVE: To examine the association between pubertal timing and cardiometabolic markers among adolescents.STUDY DESIGN: We used data from Dutch adolescents participating in a birth cohort study. The study population for the current study consisted of 799 adolescents of whom data were available for at least 1 of the exposure variables (pubertal timing and/or age at menarche) and any of the cardiometabolic markers (waist circumference, cholesterol, blood pressure [BP], glycated hemoglobin) measured at age 16 years. Adolescents self-reported pubertal development at ages 11, 14, and 16 years. We categorized participants with early (84 girls, 88 boys), intermediate (240 girls, 211 boys), or late pubertal timing (89 girls, 85 boys). We estimated differences in cardiometabolic markers using linear regression analysis.RESULTS: Girls with early pubertal timing had 1.54 cm larger waist circumference (95% CI .05; 3.03) and 3.98 mm Hg higher systolic BP (95% CI 1.69; 6.27) at age 16 years than girls with intermediate pubertal timing. The association with systolic BP remained after adjusting for childhood body mass index (BMI) (age 8 years) but attenuated after adjusting for BMI in adolescence (age 16 years). Boys with early pubertal timing had 0.79 mmol/mol lower glycated hemoglobin (95%CI -1.38; -0.20) than boys with intermediate pubertal timing.CONCLUSIONS: Girls with early pubertal timing had unfavorable BP levels at age 16 years, independent of BMI in childhood. Girls and boys with late pubertal timing had a tendency for lower waist circumference, but no differences in other cardiometabolic markers. Late pubertal timing does not appear to be a risk factor for unfavorable cardiometabolic markers in adolescence.
Published: 2017

19. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author: Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Abstract: Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. A microarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), and transcriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4 years and 11,080 children aged 8 years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.
Published: 2017

20. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Author: Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, Slama, Rémy, Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, and Slama, Rémy
Abstract: Atmospheric pollutants and meteorological conditions are suspected to be causes of preterm birth. We aimed to characterize their possible association with the risk of preterm birth (defined as birth occurring before 37 completed gestational weeks). We pooled individual data from 13 birth cohorts in 11 European countries (71,493 births from the period 1994-2011, European Study of Cohorts for Air Pollution Effects (ESCAPE)). City-specific meteorological data from routine monitors were averaged over time windows spanning from 1 week to the whole pregnancy. pressure measurements (nitrogen oxides and particulate matter) were combined with data from permanent monitors and land-use data into seasonally adjusted land-use regression models. Preterm birth risks associated with air pollution and meteorological factors were estimated using adjusted discrete-time Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: 1.01, 1.11), which could not be distinguished from altitude. There was also some evidence of an increase in preterm birth risk with first-trimester average temperature in the -5°C to 15°C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of adverse association with atmospheric pollutants was observed. Our study lends support for an increase in preterm birth risk with atmospheric pressure.
Published: 2017

21. Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

Author: Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, Melén, Erik, Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, and Melén, Erik
Abstract: RATIONALE: The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent, and may depend on genetic factors.OBJECTIVES: To identify gene-environment interaction effects on childhood asthma using genome-wide single nucleotide polymorphism (SNP) data and air pollution exposure. Identified loci were further analyzed at epigenetic and transcriptomic levels.METHODS: We used land use regression models to estimate individual air pollution exposure (represented by outdoor NO2 levels) at the birth address and performed a genome-wide interaction study for doctor's diagnosis of asthma up to 8 years in three European birth cohorts (n=1,534) with look-up for interaction in two separate North American cohorts, CHS and CAPPS/SAGE (n=1,602 and 186 subjects, respectively). We assessed eQTL effects in human lung specimens and blood, as well as associations between air pollution exposure, methylation and transcriptomic patterns.MEASUREMENTS AND MAIN RESULTS: In the European cohorts, 186 SNPs had an interaction p-value<1x10(-4) and look-up evaluation of these disclosed eight SNPs in four loci with interaction p<0.05 in the large CHS study, but not in CAPPS/SAGE. Three SNPs within ADCY2 showed same direction of interaction effect, and were found to influence ADCY2 gene expression in peripheral blood (p=4.50x10(-4)). One other SNP with p<0.05 for interaction in CHS, rs686237, strongly influenced B4GALT5 expression in lung tissue (p=1.18x10(-17)). Air pollution exposure was associated with differential DLG2 methylation and expression.CONCLUSION: Our results indicate that gene-environment interactions are important for asthma development and provide supportive evidence for interaction with air pollution for ADCY2, B4GALT5 and DLG2.
Published: 2017

22. Suitability of australian electronic medical records to guide the design of the novelty study

Author: Reddel, Helen K., De Verdier, Maria Gerhardsson, Agusti, Alvar, Beasley, Richard, Bel, Elisabeth H., Hiller, Josh, Janson, Christer, Make, Barry, Martin, Richard J., Pavord, Ian, Postma, Dirkje, Price, David, Wong, Diana, Keen, Christina, Gardev, Asparuh, Rennard, Stephen, Svereus, Alecka, Bansal, Aruna T., Brannman, Lance, Karlsson, Niklas, Nuevo, Javier, Nyberg, Fredrik, Wang, Xia, Young, Simon, Vestbo, Jörgen, Reddel, Helen K., De Verdier, Maria Gerhardsson, Agusti, Alvar, Beasley, Richard, Bel, Elisabeth H., Hiller, Josh, Janson, Christer, Make, Barry, Martin, Richard J., Pavord, Ian, Postma, Dirkje, Price, David, Wong, Diana, Keen, Christina, Gardev, Asparuh, Rennard, Stephen, Svereus, Alecka, Bansal, Aruna T., Brannman, Lance, Karlsson, Niklas, Nuevo, Javier, Nyberg, Fredrik, Wang, Xia, Young, Simon, and Vestbo, Jörgen
Published: 2017
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23. CT-Based Local Distribution Metric Improves Characterization of COPD

Author: Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, Galbán, Craig J, Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, and Galbán, Craig J
Published: 2017

24. Pubertal Timing and Cardiometabolic Markers at Age 16 Years

Author: Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, Smit, Henriëtte A, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, and Smit, Henriëtte A
Published: 2017

25. Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease

Author: Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, Mohamed Hoesein, Firdaus AA, Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, and Mohamed Hoesein, Firdaus AA
Published: 2017

26. Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

Author: Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Published: 2017

27. Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids

Author: Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., Price, D.B., Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., and Price, D.B.
Abstract: Contains fulltext : 189792.pdf (Publisher’s version ) (Open Access)
Published: 2017

28. The emerging landscape of dynamic DNA methylation in early childhood

Author: Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, Koppelman, Gerard H, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, and Koppelman, Gerard H
Published: 2017

29. Pubertal Timing and Cardiometabolic Markers at Age 16 Years

Author: Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, Smit, Henriëtte A, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, and Smit, Henriëtte A
Published: 2017

30. CT-Based Local Distribution Metric Improves Characterization of COPD

Author: Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, Galbán, Craig J, Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, and Galbán, Craig J
Published: 2017

31. Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease

Author: Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, Mohamed Hoesein, Firdaus AA, Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, and Mohamed Hoesein, Firdaus AA
Published: 2017

32. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author: dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Published: 2017

33. Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

Author: dIRAS RA-2, Risk Assessment, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, Melén, Erik, dIRAS RA-2, Risk Assessment, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, and Melén, Erik
Published: 2017

34. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

Author: LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, Melen, Erik, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, and Melen, Erik
Published: 2017

35. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Author: LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, dIRAS RA-2, dI&I RA-I&I I&I, Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, Slama, Rémy, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, dIRAS RA-2, dI&I RA-I&I I&I, Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, and Slama, Rémy
Published: 2017

36. Control of moderate-to-severe asthma with randomized ciclesonide doses of 160, 320 and 640 μg/day

Author: Pedersen,Soren, Prasad,Niyati, Goehring,Udo-Michael, Andersson,Henrik, Postma,Dirkje, Pedersen,Soren, Prasad,Niyati, Goehring,Udo-Michael, Andersson,Henrik, and Postma,Dirkje
Abstract: Søren E Pedersen,1 Niyati Prasad,2 Udo-Michael Goehring,3 Henrik Andersson,4 Dirkje S Postma5 1Pediatric Research Unit, Kolding Hospital, University of Southern Denmark, Kolding, Denmark; 2Vertex, Phase IV & Global Strategy, London, UK; 3Vifor Pharma Ltd, Clinical Research & Biometrics, Glattbrugg, Switzerland; 4Swedish Social Insurance Agency, Government Offices of Sweden, Stockholm, Sweden; 5Department of Pulmonology, Griac Research Institute, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands Background: The inhaled corticosteroid (ICS) ciclesonide (Cic), controls asthma symptoms in the majority of patients at the recommended dose of 160 µg/day. However, the relationship between the level of asthma control and increasing doses of Cic is unknown. This study investigated whether long-term treatment with higher doses of Cic would further improve asthma symptoms in patients with uncontrolled asthma despite ICS use. Patients and methods: In a double-blind, randomized, parallel-group study, 367 patients were allocated to one of three treatment arms (Cic 160, 320 and 640 μg/day). After a single-blind, 3-week baseline period with Cic 160 µg/day, eligible patients were randomized to receive 52 weeks of treatment with Cic 160, 320 or 640 μg/day (double-blind period) during which forced expiratory volume in 1 second (FEV1), exacerbations and Asthma Control Questionnaire (ACQ) scores were measured. Results: Treatment with all the three doses was associated with significant improvements in ACQ scores, FEV1 and asthma symptoms (P<0.01). There were no statistically significant differences between the three doses. The results of the primary end point analysis showed a numerical improvement in the ACQ score with Cic 640 μg/day compared with Cic 160 μg/day (least square [LS] mean: -0.122; two
Published: 2017

37. Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

Author: Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Published: 2017

38. Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids

Author: Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., Price, D.B., Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., and Price, D.B.
Abstract: Contains fulltext : 189792.pdf (Publisher’s version ) (Open Access)
Published: 2017

39. Pubertal Timing and Cardiometabolic Markers at Age 16 Years

Author: Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, Smit, Henriëtte A, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, and Smit, Henriëtte A
Published: 2017

40. Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes

Author: Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Published: 2017

41. CT-Based Local Distribution Metric Improves Characterization of COPD

Author: Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, Galbán, Craig J, Hoff, Benjamin A, Pompe, Esther, Galbán, Stefanie, Postma, Dirkje S, Lammers, Jan-Willem J, Ten Hacken, Nick H T, Koenderman, Leo, Johnson, Timothy D, Verleden, Stijn E, de Jong, Pim A, Mohamed Hoesein, Firdaus, van den Berge, Maarten, Ross, Brian D, and Galbán, Craig J
Published: 2017

42. Parametric response mapping on chest computed tomography associates with clinical and functional parameters in chronic obstructive pulmonary disease

Author: Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, Mohamed Hoesein, Firdaus AA, Pompe, Esther, Galbán, Craig J., Ross, Brian D., Koenderman, Leo, ten Hacken, Nick HT, Postma, Dirkje S., van den Berge, Maarten, de Jong, Pim A., Lammers, Jan Willem J, and Mohamed Hoesein, Firdaus AA
Published: 2017

43. Asthma-Related Outcomes in Patients Initiating Extrafine Ciclesonide or Fine-Particle Inhaled Corticosteroids

Author: Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., Price, D.B., Postma, Dirkje S., Dekhuijzen, R., Molen, T. van der, Martin, Richard J., Aalderen, W.M. van, Roche, N., Hillyer, Elizabeth V., and Price, D.B.
Abstract: Contains fulltext : 189792.pdf (Publisher’s version ) (Open Access)
Published: 2017

44. The emerging landscape of dynamic DNA methylation in early childhood

Author: LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, Koppelman, Gerard H, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Xu, Cheng-Jian, Bonder, Marc Jan, Söderhäll, Cilla, Bustamante, Mariona, Baïz, Nour, Gehring, Ulrike, Jankipersadsing, Soesma A, Van Der Vlies, Pieter, van Diemen, Cleo C, van Rijkom, Bianca, Just, Jocelyne, Kull, Inger, Kere, Juha, Antó, Josep Maria, Bousquet, Jean, Zhernakova, Alexandra, Wijmenga, Cisca, Annesi-Maesano, Isabella, Sunyer, Jordi, Melén, Erik, Li, Yang, Postma, Dirkje S, and Koppelman, Gerard H
Published: 2017

45. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author: dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, Xu, Cheng-Jian, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Anto, Josep M, Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S, Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N, Lodrup Carlsen, Karin C, Koppelman, Gerard H, Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L, Maier, Dieter, Melén, Erik, Smit, Henriette A, Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M, Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C, Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J, Siroux, Valerie, Tischer, Christina G, Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
Published: 2017

46. Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure

Author: LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, Melen, Erik, LS IRAS EEPI ME (Milieu epidemiologie), dIRAS RA-2, Gruzieva, Olena, Xu, Cheng-Jian, Breton, Carrie V, Annesi-Maesano, Isabella, Anto, Josep M, Auffray, Charles, Ballereau, Stephane, Bellander, Tom, Bousquet, Jean, Bustamante, Mariona, Charles, Marie Aline, de Kluizenaar, Yvonne, den Dekker, Herman T, Duijts, Liesbeth, Felix, Janine F, Gehring, Ulrike, Guxens, Monica, Jaddoe, Vincent W V, Jankipersadsing, Soesma A, Merid, Simon Kebede, Kere, Juha, Kumar, Ashish, Lemonnier, Nathanael, Lepeule, Johanna, Nystad, Wenche, Page, Christian Magnus, Panasevich, Sviatlana, Postma, Dirkje, Slama, Remy, Sunyer, Jordi, Soderhall, Cilla, Yao, Jin, London, Stephanie J, Pershagen, Goran, Koppelman, Gerard H, and Melen, Erik
Published: 2017

47. Genome-wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up

Author: dIRAS RA-2, Risk Assessment, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, Melén, Erik, dIRAS RA-2, Risk Assessment, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, Gref, Anna, Kebede Merid, Simon, Gruzieva, Olena, Ballereau, Stéphane, Becker, Allan, Bellander, Tom, Bergström, Anna, Bossé, Yohan, Bottai, Matteo, Chan-Yeung, Moira, Fuertes, Elaine, Ierodiakonou, Despo, Jiang, Ruiwei, Joly, Stéphane, Jones, Meaghan, Kobor, Michael S, Korek, Michal, Kozyrskyj, Anita L, Kumar, Ashish, Lemonnier, Nathanaël, MacIntyre, Elaina, Ménard, Camille, Nickle, David, Obeidat, Ma'en, Pellet, Johann, Standl, Marie, Sääf, Annika, Söderhäll, Cilla, Tiesler, Carla Mt, van den Berge, Maarten, Vonk, Judith M, Vora, Hita, Xu, Cheng-Jian, Antó, Josep M, Auffray, Charles, Brauer, Michael, Bousquet, Jean, Brunekreef, Bert, Gauderman, W James, Heinrich, Joachim, Kere, Juha, Koppelman, Gerard H, Postma, Dirkje, Carlsten, Christopher, Pershagen, Göran, and Melén, Erik
Published: 2017

48. The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth

Author: LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, dIRAS RA-2, dI&I RA-I&I I&I, Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, Slama, Rémy, LS IRAS EEPI ME (Milieu epidemiologie), Dep IRAS, dIRAS RA-2, dI&I RA-I&I I&I, Giorgis-Allemand, Lise, Pedersen, Marie, Bernard, Claire, Aguilera, Inmaculada, Beelen, Rob M J, Chatzi, Leda, Cirach, Marta, Danileviciute, Asta, Dedele, Audrius, van Eijsden, Manon, Estarlich, Marisa, Fernández-Somoano, Ana, Fernández, Mariana F, Forastiere, Francesco, Gehring, Ulrike, Grazuleviciene, Regina, Gruzieva, Olena, Heude, Barbara, Hoek, Gerard, de Hoogh, Kees, van den Hooven, Edith H, Håberg, Siri E, Iñiguez, Carmen, Jaddoe, Vincent W V, Korek, Michal, Lertxundi, Aitana, Lepeule, Johanna, Nafstad, Per, Nystad, Wenche, Patelarou, Evridiki, Porta, Daniela, Postma, Dirkje, Raaschou-Nielsen, Ole, Rudnai, Peter, Siroux, Valérie, Sunyer, Jordi, Stephanou, Euripides, Sørensen, Mette, Eriksen, Kirsten Thorup, Tuffnell, Derek, Varró, Mihály J, Vrijkotte, Tanja G M, Wijga, Alet, Wright, John, Nieuwenhuijsen, Mark J, Pershagen, Göran, Brunekreef, Bert, Kogevinas, Manolis, and Slama, Rémy
Published: 2017

49. Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Author: Hobbs, Brian, Hobbs, Brian, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María, Wain, Louise, Hall, Ian, Jackson, Victoria, Wyss, Annah, London, Stephanie, North, Kari, Franceschini, Nora, Strachan, David, Beaty, Terri, Hokanson, John, Crapo, James, Castaldi, Peter, Chase, Robert, Bartz, Traci, Heckbert, Susan, Psaty, Bruce, Gharib, Sina, Zanen, Pieter, Lammers, Jan, Oudkerk, Matthijs, Groen, H, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen, Vestbo, Jørgen, Timens, Wim, Paré, Peter, Latourelle, Jeanne, Dupuis, Josée, OConnor, George, Wilk, Jemma, Kim, Woo, Lee, Mi, Oh, Yeon-Mok, Vonk, Judith, de Koning, Harry, Leng, Shuguang, Belinsky, Steven, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen, Barr, R, Sparrow, David, Litonjua, Augusto, Bakke, Per, Gulsvik, Amund, Lahousse, Lies, Brusselle, Guy, Stricker, Bruno, Uitterlinden, André, Ampleford, Elizabeth, Bleecker, Eugene, Meyers, Deborah, Qiao, Dandi, Lomas, David, Yim, Jae-Joon, Kim, Deog, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Hardin, Megan, Fingerlin, Tasha, Schwartz, David, Postma, Dirkje, MacNee, William, Tobin, Martin, Silverman, Edwin, Boezen, H, Cho, Michael, Woodruff, Prescott, Hobbs, Brian, Hobbs, Brian, de Jong, Kim, Lamontagne, Maxime, Bossé, Yohan, Shrine, Nick, Artigas, María, Wain, Louise, Hall, Ian, Jackson, Victoria, Wyss, Annah, London, Stephanie, North, Kari, Franceschini, Nora, Strachan, David, Beaty, Terri, Hokanson, John, Crapo, James, Castaldi, Peter, Chase, Robert, Bartz, Traci, Heckbert, Susan, Psaty, Bruce, Gharib, Sina, Zanen, Pieter, Lammers, Jan, Oudkerk, Matthijs, Groen, H, Locantore, Nicholas, Tal-Singer, Ruth, Rennard, Stephen, Vestbo, Jørgen, Timens, Wim, Paré, Peter, Latourelle, Jeanne, Dupuis, Josée, OConnor, George, Wilk, Jemma, Kim, Woo, Lee, Mi, Oh, Yeon-Mok, Vonk, Judith, de Koning, Harry, Leng, Shuguang, Belinsky, Steven, Tesfaigzi, Yohannes, Manichaikul, Ani, Wang, Xin-Qun, Rich, Stephen, Barr, R, Sparrow, David, Litonjua, Augusto, Bakke, Per, Gulsvik, Amund, Lahousse, Lies, Brusselle, Guy, Stricker, Bruno, Uitterlinden, André, Ampleford, Elizabeth, Bleecker, Eugene, Meyers, Deborah, Qiao, Dandi, Lomas, David, Yim, Jae-Joon, Kim, Deog, Hawrylkiewicz, Iwona, Sliwinski, Pawel, Hardin, Megan, Fingerlin, Tasha, Schwartz, David, Postma, Dirkje, MacNee, William, Tobin, Martin, Silverman, Edwin, Boezen, H, Cho, Michael, and Woodruff, Prescott
Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide. We performed a genetic association study in 15,256 cases and 47,936 controls, with replication of select top results (P < 5 × 10-6) in 9,498 cases and 9,748 controls. In the combined meta-analysis, we identified 22 loci associated at genome-wide significance, including 13 new associations with COPD. Nine of these 13 loci have been associated with lung function in general population samples, while 4 (EEFSEC, DSP, MTCL1, and SFTPD) are new. We noted two loci shared with pulmonary fibrosis (FAM13A and DSP) but that had opposite risk alleles for COPD. None of our loci overlapped with genome-wide associations for asthma, although one locus has been implicated in joint susceptibility to asthma and obesity. We also identified genetic correlation between COPD and asthma. Our findings highlight new loci associated with COPD, demonstrate the importance of specific loci associated with lung function to COPD, and identify potential regions of genetic overlap between COPD and other respiratory diseases.
Published: 2017

50. Pubertal Timing and Cardiometabolic Markers at Age 16 Years

Author: Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Child Health, Circulatory Health, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, Smit, Henriëtte A, Public Health Epidemiologie, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Child Health, Circulatory Health, Berentzen, Nina E, Wijga, Alet H, van Rossem, Lenie, Postma, Dirkje S., Gehring, Ulrike, and Smit, Henriëtte A
Published: 2017

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