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2. Dienste, Werke und Einrichtungen im Horizont einer Öffentlichen Kirche
- Author
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Elhaus, Philipp, Pohl-Patalong, Uta, Elhaus, P ( Philipp ), Pohl-Patalong, U ( Uta ), Schlag, Thomas; https://orcid.org/0000-0002-3269-7493, Elhaus, Philipp, Pohl-Patalong, Uta, Elhaus, P ( Philipp ), Pohl-Patalong, U ( Uta ), and Schlag, Thomas; https://orcid.org/0000-0002-3269-7493
- Published
- 2024
3. Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey
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Shalaby, M, Elsheikh, A, Hamed, H, Null, N, Elsheik, A, Sakr, A, Fouad, A, Kassem, A, Elfeki, H, Madbouly, K, Alzahrani, K, Marzouk, K, Ali, M, Helal, M, Elsorogy, M, Farid, M, Di Lorenzo, N, Sileri, P, Wexner, S, Khafagy, W, Adeyeye, A, El-Hussuna, A, Frontali, A, Saklani, A, Lelpo, B, Molena, D, Pandey, D, Karbovnichaya, E, Pata, F, Van Ramshor, G, Gallo, G, Spolverato, G, Pellino, G, Bagaglini, G, Rubio-Perez, I, Negoi, I, Frigerio, I, Juloski, J, Ninkovic, M, Franceschilli, M, Azer, M, Efetov, S, Ippoliti, S, Garoufalia, Z, Fazli, M, Dogjani, A, Cherfa, H, Omar, T, Minoldo, J, Alvarez Gallesio, J, Quesada, M, Bacher, A, Kropshofer, S, Ponholzer, F, Tesik, P, Gehwolf, P, Isci, S, Uranitsch, S, Berchtold, V, Samadov, E, Abualsel, A, Mitul, A, Islam, S, Vanlander, A, Van Praet, C, Van Daele, E, Vanommeslaeghe, H, Stijns, J, Abosi-Appeadu, K, Depuydt, M, Allaeys, M, Yves, V, Colleoni, R, Slavchev, M, Elbahrawy, A, Luc, J, Milford, K, Romic, I, Monti, A, Haydal, A, Klein, M, Ocklind, M, Hadi, S, Alqasaby, A, Elganash, A, Daibes, A, Elsaied, A, Elhattab, A, Lotfy, A, Alnashar, A, Elnour, A, Abdelhalim, A, Abdelhamid, A, Abdellatif, A, Abdelmohsen, A, Abdelrafee, A, Elhawary, A, Zidan, A, Eleshra, A, Elkafoury, A, Ezz, A, Abdelmomen, A, Elkased, A, Fawzy, A, Elkhouly, A, Hemidan, A, Abbas, A, Ismail, A, Attia, A, Farid, A, Elnakash, A, Negida, A, Soliman, A, Taki-Eldin, A, Albadry, A, Sanad, A, Elbatal, A, Elgazar, A, Saleh, A, Fahiem, A, Mohamed, A, Nageeb, A, Elmetwally, A, Alkhalegy, A, El-Wakeel, A, Shemes, A, Fadel, B, Lutfi, B, Ali, D, Abolnasr, K, Gamal, E, Abdallah, E, Ahmed, E, Salem, E, Hamed, E, Elshikh, E, Enad, F, Sarhan, F, Abouelnagah, G, Tagg, G, Atef, G, Shaker, G, Beshir, H, Zakaria, H, Barbary, H, Elgendy, H, Sharaf, H, Elnaghi, H, Elghadban, H, Elzayat, I, Fakhr, I, Sallam, I, Abdelmoneim, I, Elnemr, I, Zewar, K, Elalfy, K, Sabet, K, Mansour, K, Osman, K, Elgaly, M, Shams, M, Abozeid, M, Mohammed, M, Elkatt, M, Samaha, M, Mikhael, M, Khalil, M, Alhendawey, M, Elrefai, M, Gabr, M, Fayed, M, Abdelmaksoud, M, Salem, M, Mohamed Mohamed, M, Nabeeh, M, Elsayed, M, Abdelmonem, M, Eldemery, M, Elmesery, M, Fikry, M, Gharbia, M, Omar, M, Elmoghazy, M, Ghazala, M, Hamed, M, Metwally, M, Arnouse, M, Amen, M, Amary, M, Kandel, M, Abuzeid, M, Rabea, M, Sobh, M, Taman, M, Fathy, M, Moustafa, M, Zuhdy, M, Adel, M, Alaa, M, Alawady, M, Edassy, M, Eldesouki, M, Salim, M, Sanad, M, Khalaf, M, Henes, M, Abdelglil, M, Mohmmed, M, Abdelkhalik, M, Shetiwy, M, Elshazli, M, Hegazy, M, Ahmed, M, Abdelhalim, M, Shahein, M, Sofan, M, Hammad, M, Ahmad, M, Milad, N, Farouk, N, Eldesouky, O, Mohamed, O, Mahadel, O, Gaarour, O, Torky, R, Elhafez, R, Adly, R, Nageeb, R, Hamdi, S, Gamal, S, Emile, S, Regal, S, Abdelrasheed, S, Elzeftawy, S, Khashshan, S, Ashraf, T, Khafagy, T, Nabil, T, Abdelazim, T, Rizk, T, Amr, W, Yousef, Y, Youssef, Y, Castaldi, A, Fiore, A, Hasani, A, Mariani, A, Dagorno, C, Antonio, D, Izzo, G, Addari, G, Mangiameli, G, Rea, L, Pio, L, Paci, M, Andrea, P, De Fatico, G, Elvira, T, Schuldes, A, Rihan, E, Moeslein, G, Lederhuber, H, Botros, I, Jaman, I, Doerner, J, Elseberbihy, J, Sherbiny, K, Ghonim, M, Mikrish, A, Aziz, M, Hatm, M, Archid, R, Gendy, S, Ahmad, S, Charalabopoulos, A, Prodromidou, A, Ioannidis, A, Mpaili, E, Boukorou, G, Papadopoulos, G, Liakakos, T, Styliani, V, Agrawal, A, Jain, A, Rashid, A, Mehraj, A, Brahmachari, S, Lakshmi, H, Vishwakarma, K, Parida, L, Sharma, M, Zaieem, M, Makasarwala, M, Nittala, R, Kumar, S, Vikrantmr, S, Junaid, S, Khuller, S, More, V, Ahmed, A, Alomieri, A, Alhamdany, A, Del, M, Najm, G, Lateef, N, Mcnamara, D, Abdelmageed, M, Majeed, M, Troci, A, Porcu, A, Marano, A, Di Bartolomeo, A, Giani, A, Giardino, A, Canfora, A, Balla, A, Barberis, A, Belli, A, Borasi, A, Manetti, A, Mingoli, A, Morini, A, Maurizi, A, Marra, A, Epifani, A, Iossa, A, Parello, A, Guida, A, Maffioli, A, Scafa, A, Spinelli, A, Matarangolo, A, Picciariello, A, Pirozzi, B, Cirillo, B, Gazia, C, Ratto, C, Foppa, C, Marafante, C, Andrea, C, Tanda, C, Guerci, C, Don, C, Zigiotto, D, Coniglio, D, Sasia, D, Visconti, D, Altomare, D, Guaitoli, E, Botteri, E, Pinotti, E, Martinelli, F, Uggeri, F, Bàmbina, F, Falaschi, F, Costanzo, F, La Torre, F, Milana, F, Abbatini, F, De Lucia, F, Tropeano, F, Colombo, F, Ferrara, F, Litta, F, Carrano, F, Orlando, F, Roscio, F, Selvaggi, F, Giarratano, G, Pagano, G, Lisi, G, Argenio, G, Zancana, G, Cavallaro, G, Frazzetta, G, Mariateresa, G, Sciaudone, G, Vella, I, Siragusa, L, Santurro, L, Ferri, L, Petagna, L, Ferrario, L, Pitoni, L, Pignatelli, M, Angrisani, M, Giugliano, M, Inama, M, Marino, M, Veltri, M, Giuffrida, M, Menna, M, Valente, M, Rottoli, M, Sacchi, M, Uccelli, M, Rho, M, Garino, M, Montuori, M, Campanelli, M, Zese, M, De Falco, N, Cillara, N, Mariani, N, Tamini, N, Adorisio, O, Campennì, P, Venturelli, P, Bernante, P, Sapienza, P, Cianci, P, Marsanic, P, Lapolla, P, Tecchio, P, Familiari, P, Fransvea, P, Bruzzaniti, P, Hassan, R, Pirovano, R, Rimonda, R, Di Saverio, S, Di Carlo, S, Perra, T, Campagnaro, T, Testa, V, Andriola, V, Grappelli, V, Capizzi, V, Chiarella, V, Bellato, V, Yanaga, K, Farouk, M, Uraiqat, A, Almasri, M, Nabwana, A, Siboe, M, W, N, Njoroge, G, Ilkul, J, Obure, R, Palkhi, Y, Alkhayat, A, Ali, A, Malek, A, Abdelsayed, E, Zahra, T, Ayoub, L, Sleilati, F, Aoun, R, Algatanesh, N, Fieturi, N, Ng, J, Díaz, A, Duran, E, Guerrero, J, Jasso, M, Flores, M, Felix, M, Angulo, V, Mejdane, A, Aitali, A, Amal, B, Zentar, A, Bensaad, A, Yacir, E, Jawad, F, Rachid, M, Maliki-Alaoui, M, Ouadii, M, Mohammed, O, Thein, N, Koirala, D, Hilling, D, Pouwels, S, Okunlola, A, Adejumo, A, Akinmade, A, Shittu, A, Oluyomi, A, Abiodun, A, Lawal, B, Odion, C, Popoola, A, Jolayemi, E, Shomoye, E, Wuraola, F, Eke, G, Abiyere, H, Oluwasuyi, I, George, I, Njokanma, I, Aremu, I, Dare, J, Abdur-Rahman, L, Oludara, M, Mohammad, M, Adeoluwa, O, Situ, O, Agbonrofo, P, Kewulere, R, Aliyu, Y, Adebowale, Y, Galala, A, Rao, S, Waleed, A, Inam, A, Shaikh, A, Qureshi, A, Muhammad, A, Kerawala, A, Aslam, M, Mehr, A, Javed, A, Ahmad, F, Majid, H, Ahmed, H, Daudi, I, Akhtar, K, Niaz, K, Anwer, M, Amir, M, Hanif, M, Asif, M, Raza, M, Khokhar, M, Jameel, M, Nasir, M, Shafique, M, Ateeb, M, Nadeem, M, Shah, R, Waqar, S, Shah, S, Waseem, T, Ghafoor, T, Fatima, T, Bashir, U, Gonzales, E, Ruiz, L, Freitas, C, De Sousa, X, Al-Bahrani, A, Portela, C, Elgazar, E, Robles, E, Khan, I, Jarboa, L, Khawar, M, Echevarria, M, Bashah, M, Dawdi, S, Musthafa, S, Ali, S, Ciubotaru, C, Bonci, E, Muresan, M, Bogdan, S, Ioan, T, Zubayraeva, A, Derinov, A, Zakharenko, A, Novikova, A, Bashlachev, A, Kaldarov, A, Stanislav, B, Gorin, D, Puzenko, D, Kazachenko, E, Ashimov, E, Medkova, I, Ignatov, I, Sergeevich, K, Sidorova, L, Kiselev, M, Danilov, M, Aleksandr, O, Rodimov, S, Garmanovs, T, Kitsenko, Y, Valery, N, Japhet, N, Sibiany, A, Saadeldin, A, Abuosba, A, Alawadhi, A, Alharbi, A, Althumali, A, Alghuliga, A, Alotaibi, A, Abduraboh, A, Kateb, A, Sindy, A, Al Eisa, A, Almulhim, A, Aljawhari, A, Abozeid, A, Saad, A, Alqarni, A, Alwan, A, Alwusaibie, A, Bafaraj, A, Eldeeb, A, Tarabay, A, Alhedaithy, A, Almaghrabi, A, Abed, A, Abdullah, A, Semilan, A, Farag, M, Khudhayr, E, Hussain, M, Abbas, G, Alqudaihi, H, Abualnaja, Y, Shaheen, A, Mubarak, A, Ali, B, Alhazmi, B, Hijazi, B, Abdulrahman, C, Oyedepo, C, Alzamel, H, Tairab, E, Alsuwaimel, M, Hejazi, S, Alnoqaidan, E, Alhussien, F, Jallad, F, Khadwardi, F, Alghamdi, F, Haddad, F, Sauri, F, Alafghani, H, Alfalah, H, Gad, H, Aboelmagid, H, Ibrahim, H, Elzayady, H, Sharafeldin, H, Sembawa, H, Alabbas, H, Abbas, H, Elgamal, H, Alawfi, H, Al-Sadery, H, Abdelmotaleb, H, Al Hassn, I, Mudawi, I, Nekhala, I, Elsanhoury, K, Said, K, Albeshri, K, Albahooth, K, Mohammed, K, Asar, K, Osman, L, Alzamanan, M, Alnabarawi, M, Althobaiti, M, Al Naeb, M, Hassan, M, Abdelhamid, M, Alyami, M, Mirza, M, Sayouh, M, Alkhayat, M, Basendowah, M, Ghunaim, M, Alhussaini, M, Khoj, M, Sbaih, M, Saeed, M, Abdelaziz, N, Malibary, N, Abdo, N, Amer, N, Al Turki, N, Durayb, N, Yassin, N, Akeel, N, Larbi, N, Alsallum, O, Suliman, O, Elsherbiny, O, Abusalem, O, Albalawi, I, Abutalib, R, Alarabi, R, Khan, R, Alazzam, S, Alghamdi, S, Alsawat, S, Salim, S, Alshukr, S, Alzahrani, S, Golea, S, Alowairdhi, T, Salman, U, Abusiam, W, Abualkhair, W, Saber, W, Tashkandi, W, Alhazmi, W, Yassine, W, Alshabi, Y, Ibrahim, Y, Shahin, Y, Aljathlany, Y, Alnahas, Y, Alrashidi, Y, Wali, Z, Ndong, A, Ba, M, Faye, P, Arbutina, D, Milic, L, Cuk, V, Hussein, A, Mccaul, J, Bertels, L, Pohl, L, Arnold, M, Mbatani, N, Oosthuizen, P, Rayamajhi, S, Vosloo, S, Jooma, U, Landaluce-Olavarria, A, Vázquez-Melero, A, Marcos, A, Puerto Puerto, A, De La Hermosa, A, Senent-Boza, A, Ugarte-Sierra, B, Montalbán, B, Martin-Perez, B, Gomez, C, Colás-Ruiz, E, Santos, E, Senra, F, Mora-Guzmán, I, Dziakova, J, Díaz, J, Silva, J, Laina, J, Tallon-Aguilar, L, Di Martino, M, Chacón, M, Frasson, M, Calvo, M, Millan, M, Tejedoe, P, Pérez-Bertólez, S, Turrado-Rodríguez, V, Elsanosi, A, Abdalbakheet, D, Salim, O, Youssef, M, Barbon, C, Bouchrika, A, Maghrebi, H, Loukil, I, Yildiz, A, Dursun, A, Gulcu, B, Calik, B, Eral, B, Yeşilyurt, D, Yakar, F, Akin, F, Kilinc, G, Uslu, G, Tuncer, K, Koc, M, Leventoğlu, S, Sokmen, S, Atici, S, Kaya, T, Dere, Ü, Kırmızı, Y, Ssenono, K, Lule, H, Mbiine, R, Hamza, A, Peediyakkal, S, Varma, G, Mussa, H, Al-Masari, H, Shehata, M, Seiam, M, Nimir, N, Khare, R, Rashid, S, Kazim, S, Gondal, Z, Sherif, A, Ghanem, A, Helmy, A, Ibrahim, A, Elshaer, A, Marzouk, A, Tamburrini, A, Parente, A, Light, A, Diamantopoulou, A, Singh, B, Gurung, B, Frauenfelder, C, Leo, C, Raptis, D, Thakrar, D, Madhuri, T, Tsounaki, E, Garreffa, E, Soggiu, F, Stavrou, G, Ng, H, Tabasi, H, Nasef, H, Kostakis, I, Jeffery, J, Warusavitarne, J, Lund, J, Qurashi, K, Sahnan, K, Tong, K, Orecchia, L, Kaur, M, Zaidi, M, Ganau, M, Curtis, N, Bhatt, N, Machairas, N, Zafar, N, Toma, O, Sarmah, P, Bassuni, M, Davies, J, Shawer, S, Lewis, S, Subramanian, S, Nadeem, U, Njau, A, Tohamy, A, Pakula, A, Simioni, A, Jarvis, B, Skandalakis, G, Hesham, H, Isaiah, I, Villwock, J, Martin, L, Kress, M, Sebelik, M, Lathan, S, Towfigh, S, Holubar, S, Demeester, S, Alshehari, M, Ghabisha, S, Abdulatef, S, Al-Kubati, W, Obadiel, Y, Gots, A, Nakazwe, M, Chipaila, J, Mazingi, D, Shalaby, Mostafa, ElSheikh, Ahmed M., Hamed, Hosam, null, null, Elsheik, Ahmed, Sakr, Ahmad, Fouad, Amgad, Kassem, Amr, Elfeki, Hossam, Madbouly, Khaled, Alzahrani, Khalid H., Marzouk, Khalid, Ali, Mahmoud, Helal, Mohamed Alaa Abdelmoez, Elsorogy, Mohamed, Farid, Mohamed, Di Lorenzo, Nicola, Sileri, Pierpaolo, Wexner, Steven, Khafagy, Wael, Adeyeye, Ademola, El-Hussuna, Alaa, Frontali, Alice, Saklani, Avanish, Lelpo, Benedettao, Molena, Daniela, Pandey, Diwakar, Karbovnichaya, Elena, Pata, Francesco, Van Ramshor, Gabrielle H., Gallo, Gaetano, Spolverato, Gaya, Pellino, Gianluca, Bagaglini, Giulia, Rubio-Perez, Ines, Negoi, Ionut, Frigerio, Isabella, Juloski, Jovan, Ninkovic, Marijana, Franceschilli, Marzia, Azer, Mina, Efetov, Sergey, Ippoliti, Simona, Garoufalia, Zoe, Fazli, Mohammad Rafi, Dogjani, Agron, Cherfa, Harieche Abdennour Abderahim, Omar, Tilioua, Minoldo, Javier, Alvarez Gallesio, José Maria, Quesada, Matias, Bacher, Annica, Kropshofer, Stephan, Ponholzer, Florian, Tesik, Philip, Gehwolf, Philipp, Isci, Sevim, Uranitsch, Stefan, Berchtold, Valeria, Samadov, Elgun, Abualsel, Abdulmenem, Mitul, Ashrarur Rahman, Islam, S. M. Nazmul, Vanlander, Aude, Van Praet, Charles, Van Daele, Elke, Vanommeslaeghe, Hanne, Stijns, Jasper, Abosi-Appeadu, Kessewa, Depuydt, Martijn, Allaeys, Mathias, Yves, Van Nieuwenhove, Colleoni, Ramiro, Slavchev, Mihail, Elbahrawy, Aly, Luc, Jessica G. Y., Milford, Karen, Romic, Ivan, Monti, Alessio, Haydal, Ashraf, Klein, Mads Falk, Ocklind, Miranda E. K., Hadi, Sabah Anwar, Alqasaby, Abdallah, Elganash, Abdelazim, Daibes, Adel Goda Hussein, Elsaied, Adham, Elhattab, Ahmad, Lotfy, Ahmad, Alnashar, Ahmed, Elnour, Ahmed Abd Elbaset Elsayed Abu, Abdelhalim, Ahmed, Abdelhamid, Ahmed, Abdellatif, Ahmed, Abdelmohsen, Ahmed, Abdelrafee, Ahmed, Elhawary, Ahmed Adel, Zidan, Ahmed Azmy, Eleshra, Ahmed, Elkafoury, Ahmed, Ezz, Ahmed, Abdelmomen, Ahmed Ezzat Elghrieb, Elkased, Ahmed Farag, Fawzy, Ahmed, Elkhouly, Ahmed G., Hemidan, Ahmed Gamal Abouelfetouh Ibrahim, Abbas, Ahmed Hosam Eldin Hasan, Ismail, Ahmed Mahmoud Ahmed, Attia, Ahmed Mohamed, Farid, Ahmed Mohammed, Elnakash, Ahmed Mostafa, Negida, Ahmed, Soliman, Ahmed, Taki-Eldin, Ahmed, Albadry, Ali Almahdy Ali, Sanad, Aly, Elbatal, Amira Alsayed Abdelhai, Elgazar, Amr, Saleh, Amr, Fahiem, Andrew, Mohamed, Anwar Yahya A., Nageeb, Ashraf, Elmetwally, Ashraf S., Alkhalegy, Ayman, El-Wakeel, Ayman, Shemes, Ayman, Fadel, Bashir A., Lutfi, Basma Waseem, Ali, Doaa, Abolnasr, Khaled Samir, Gamal, Ehab, Abdallah, Emad, Ahmed, Emad Ali, Salem, Eman Abdalla Mohamed, Hamed, Esmael Ali, Elshikh, Essam, Enad, Farazdaq, Sarhan, Fetoh Alaaeldin Fetoh, Abouelnagah, Galal, Tagg, Gamal Hassan El, Atef, Gehad, Shaker, George Samir Habib, Beshir, Hatem, Zakaria, Hazem M., Barbary, Hesham, Elgendy, Hesham, Sharaf, Hesham, Elnaghi, Hisham, Elghadban, Hosam, Elzayat, Ibrahim, Fakhr, Ibrahim, Sallam, Ibrahim, Abdelmoneim, Ibrahim Tharwat Mohamed, Elnemr, Islam, Zewar, Karem Shahin Mohamed, Elalfy, Khaled, Sabet, Khaled, Mansour, Khaled Yousery Ibrahim, Osman, Khalid Abdalla Abdelgadir, Elgaly, Maher Elesawi Kamel, Shams, Maher, Abozeid, Mahmoud, Mohammed, Mahmoud M., Elkatt, Mahmoud Mohamed, Samaha, Mahmoud Yahia, Mikhael, Marolla Maher Eskander, Khalil, Medhat M. H. A., Alhendawey, Moaaz, Elrefai, Mohamad, Gabr, Mohamed A., Fayed, Mohamed Abdelaziz Mohamed Abdalla M, Abdelmaksoud, Mohamed, Salem, Mohamed Abouelmagd, Mohamed Mohamed, Mohamed Adel, Nabeeh, Mohamed Adel, Elsayed, Mohamed Ahmed Abdelhalim Ahmed, Abdelmonem, Mohamed Ahmed, Ali, Mohamed Anwar Abdel Razik, Eldemery, Mohamed, Elmesery, Mohamed, Fikry, Mohamed, Gharbia, Mohamed, Omar, Mohamed I., Elmoghazy, Mohamed Ibrahim, Ghazala, Mohamed Jomma, Hamed, Mohamed Korayem Fattouh, Metwally, Mohamed, Arnouse, Mohamed Mohamed Hamdy, Amen, Mohamed Mohsen, Amary, Mohamed Mokhtar, Kandel, Mohamed Mosaad, Abuzeid, Mohamed Mostafa, Rabea, Mohamed, Sobh, Mohamed Ramadan, Taman, Mohamed, Fathy, Mohammad, Moustafa, Mohammad Montaser Hassan, Zuhdy, Mohammad, Adel, Mohammed, Alaa, Mohammed, Alawady, Mohammed, Edassy, Mohammed El, Mohammed, Mohammed Mustafa Hassan, Eldesouki, Mohammed Nabil, Salim, Mohammed Said Mahmoud, Sanad, Mohammed, Khalaf, Mohsen George, Henes, Mohsen Michael, Abdelglil, Momen, Mohmmed, Mona Mhmoud, Abdelkhalik, Morsi Mohamed Morsi, Shetiwy, Mosab, Elshazli, Mostafa, Hegazy, Mostafa, Ahmed, Mostafa Mahmoud, Abdelhalim, Mostafa Mohammed, Shahein, Mostafa, Sofan, Mostafa, Hammad, Muhammed Alaa Moukhtar, Ahmad, Mustafa, Milad, Nader, Farouk, Nehal, Eldesouky, Omnia, Mohamed, Omnia Y., Mahadel, Osama Abdel Salam, Gaarour, Osama, Torky, Radwan Abdelsabour, Elhafez, Raheem El-Gohary Abd, Adly, Ramy Magdy, Nageeb, Ramy Mikhael, Hamdi, Salah, Gamal, Sameh, Emile, Sameh Hany, Regal, Samer, Abdelrasheed, Sayed, Elzeftawy, Shady Ahmed, Khashshan, Sohib Mohammed Mohammed, Ashraf, Tamer, Khafagy, Tamer, Nabil, Tamer, Abdelazim, Tarek, Rizk, Tarek Taher, Amr, Wesam, Yousef, Yousef Mohamed, Youssef, Youssef Abdel Aziz, Castaldi, Antonio, Fiore, Antonio, Hasani, Ariola, Mariani, Aurora, Dagorno, Claire, Antonio, D'Alessandro, Izzo, Giuliano, Addari, Giulio, Mangiameli, Giuseppe, Rea, Lo Dico, Pio, Luca, Paci, Marco, Andrea, Police, De Fatico, GSerena, Elvira, Tartaglia, Schuldes, Alejandro Daniel Lira, Rihan, Eslam, Moeslein, Gabriela, Lederhuber, Hans, Botros, Ibram, Jaman, Ismail, Doerner, Johannes, Elseberbihy, John Rezk Hanna, Sherbiny, Kareem El, Ghonim, Mostafa, Mikrish, Amir, Aziz, Mina, Hatm, Mohamed, Archid, Rami, Gendy, Samuel Elkess Morcos, Ahmad, Sufian, Charalabopoulos, Alexandros, Prodromidou, Anastasia, Ioannidis, Argyrios, Mpaili, Eustratia, Boukorou, Garyfallia, Papadopoulos, Georgios, Liakakos, Theodore, Styliani, Vasileiadou, Agrawal, Abhishek, Jain, Amita, Rashid, Arshad, Mehraj, Asif, Brahmachari, Swagata, Lakshmi, Harish Neelamraju, Vishwakarma, Kushagra, Parida, Lalit, Sharma, Meenakshi, Zaieem, Mohammad, Makasarwala, Murtaza, Nittala, Rigved, Kumar, Sanjeev, Vikrantmr, Sharma, Junaid, Sheikh, Khuller, Somyaa, More, Vinal, Ahmed, Abeer Abdul Hameed, Alomieri, Adil, Alhamdany, Arkan Shubber, Del, Muslim Ka, Najm, Ghadah, Lateef, Nawras Falah, Mcnamara, Deborah, Abdelmageed, Mohammed Elkassaby, Majeed, Mudassar, Troci, Albert, Porcu, Alberto, Marano, Alessandra, Di Bartolomeo, Alessandro, Giani, Alessandro, Giardino, Alessandro, Canfora, Alfonso, Balla, Andrea, Barberis, Andrea, Belli, Andrea, Borasi, Andrea, Manetti, Andrea, Mingoli, Andrea, Morini, Andrea, Maurizi, Angela, Marra, Angelo Alessandro, Epifani, Angelo Gabriele, Iossa, Angelo, Parello, Angelo, Guida, Anna, Maffioli, Anna, Scafa, Anthony Kevin, Spinelli, Antonino, Matarangolo, Antonio, Picciariello, Arcangelo, Pirozzi, Brunella, Cirillo, Bruno, Gazia, Carlo, Ratto, Carlo, Foppa, Caterina, Marafante, Chiara, Andrea, Chierici, Tanda, Cinzia, Guerci, Claudio, Don, Cristine, Zigiotto, Daniele, Coniglio, Denise, Sasia, Diego, Visconti, Diego, Altomare, Donato F., Guaitoli, Eleonora, Botteri, Emanuele, Pinotti, Enrico, Martinelli, Fabio, Uggeri, Fabio, Bàmbina, Fabrizio, Falaschi, Federica, Costanzo, Federico, La Torre, Filippo, Milana, Flavio, Abbatini, Francesca, De Lucia, Francesca, Tropeano, Francesca Paola, Colombo, Francesco, Ferrara, Francesco, 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Grace, Abiyere, Henry, Oluwasuyi, Ige, George, Ihediwa, Njokanma, Iloba Gabriel, Aremu, Isiaka, Dare, Julius Kolajo, Abdur-Rahman, Lukman, Ahmad, Misbahu Haruna, Oludara, Mobolaji Adewale, Mohammad, Mohammad Aminu, Adeoluwa, Ojajuni, Situ, Oladele, Agbonrofo, Peter, Kewulere, Raji Taofiq, Aliyu, Yakubu, Adebowale, Yusuf, Galala, Ahmed, Rao, Satish, Waleed, Aasma, Inam, Aatif, Shaikh, Abdul Razaque, Qureshi, Ahmad Uzair, Muhammad, Aneeqah Din, Ahmed, Arooj, Kerawala, Asad Ali, Aslam, Mohammad, Mehr, Asma, Javed, Ayesha, Ahmad, Farooq, Majid, Haroon Javaid, Ahmed, Hassan, Daudi, Irfan, Akhtar, Khalid, Niaz, Khurram, Anwer, Mariyah, Amir, Mohammed, Hanif, Muhammad Amir, Asif, Muhammad, Raza, Muhammad Asif, Khokhar, Muhammad Imran, Jameel, Muhammad Khurram, Nasir, Muhammad, Shafique, Muhammad Salman, Ateeb, Mujammad, Nadeem, Munawar, Shah, Rahmat Ullah, Waqar, Shahzad Hussain, Shah, Shahzad Alam, Waseem, Talat, Ghafoor, Tariq, Fatima, Tauseef, Bashir, Umar, Gonzales, Erick Ivan Huaman, Ruiz, Luis Angel Garcia, Freitas, Carla, De Sousa, Xavier, Al-Bahrani, Ahmed, Portela, Carlos Antonio Sanchez, Elgazar, Elsayed Aly, Robles, Eloy Morasen, Khan, Irfan Jan, Jarboa, Lutfi, Khawar, Mahwish, Echevarria, Miguel Jose Pinto, Bashah, Moataz M., Dawdi, Salahaldeen, Musthafa, Shameel, Ali, Syed Muhammad, Ciubotaru, Cezar, Bonci, Eduard-Alexandru, Muresan, Mihai-Stefan, Bogdan, Stoica, Ioan, Tanase, Zubayraeva, Albina, Derinov, Aleksandr, Zakharenko, Alexander, Novikova, Anastasia, Bashlachev, Andrey, Kaldarov, Ayrat, Stanislav, Berelavichus, Gorin, David, Puzenko, Dmitriy, Kazachenko, Ekaterina, Ashimov, Erkin, Medkova, Iuliia, Ignatov, Ivan, Sergeevich, Kochetkov Viktor, Sidorova, Lyudmila, Kiselev, Michail, Danilov, Michail, Aleksandr, Ogoreltsev, Rodimov, Sergey, Garmanovs, Tatiana, Kitsenko, Yury, Valery, Nekoval, Japhet, Ntezamizero, Sibiany, Abdulrahman, Saadeldin, Abdelhalim, Abuosba, Abdelrahman, Alawadhi, Abdulbari Mohammed, Alharbi, Abdulhamid, Althumali, Abdullah, Alghuliga, Abdullah, Alotaibi, Abdullah, Abduraboh, Abdullah Fayez, Kateb, Abdullah, Sindy, Abdullah, Al Eisa, Abdulmohsen, Alotaibi, Abdulrahman, Almulhim, Abdulrhman, Aljawhari, Adel Ali, Abozeid, Ahmad Mahmoud, Saad, Ahmad, Alqarni, Ahmed, Alwan, Ahmed, Alwusaibie, Ahmed, Bafaraj, Ahmed, Eldeeb, Ahmed, Tarabay, Ahmed, Mohammed, Mahfoudh, Alhedaithy, Alhanouf, Almaghrabi, Alhassan Hesham, Abed, Ali Ibrahim Eldawy, Abdullah, Alqahtani Ali, Semilan, Anmar, Farag, Mohamed, Khudhayr, Essa, Hussain, Marwah, Abbas, Ghanem, Alqudaihi, Heba, Abualnaja, Yousra, Shaheen, Abelnasser, Mubarak, Ashraf Abdelazeem Mohamed, Ali, Bandar Idrees A., Alhazmi, Barrag, Hijazi, Bilal Ahmed, Abdulrahman, Chadi, Oyedepo, Charles Olajide, Alzamel, Heythem, Tairab, Elsanousi Ibrahim Sabir, Alsuwaimel, Munir A., Hejazi, Soha, Alnoqaidan, Emad, Alhussien, Fade Ahmed, Jallad, Fadi Sami, Khadwardi, Faisal, Alghamdi, Faisal Saleh, Haddad, Feras, Sauri, Fozan, Alafghani, Haitham, Alfalah, Haitham, Gad, Hamada, 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Nouf, Larbi, Noureddine, Alsallum, Ofays, Suliman, Omar AAbu, Elsherbiny, Osama, Abusalem, Osama, Albalawi, Ibrahim Altedlawi, Abutalib, Raid Abdullah, Alarabi, Rayan, Khan, Roaa Ghazi, Alazzam, Saleh, Alghamdi, Saleh, Alsawat, Salem, Salim, Sami, Alshukr, Sarah, Alzahrani, Saud, Golea, Smain, Alowairdhi, Tumadher, Salman, Usama, Abusiam, Wael, Abualkhair, Wael, Saber, Wael, Tashkandi, Wail, Alhazmi, Waleed, Tashkandi, Waleed, Yassine, Wassim Abou, Alshabi, Yaser Ahmad, Ibrahim, Yaser, Shahin, Yasser, Ibrahim, Yassin, Aljathlany, Yousef, Alnahas, Yousef, Alrashidi, Yousef, Wali, Zubair, Ndong, Abdourahmane, Ba, Mamadou, Faye, Papa Mamadou, Arbutina, Dragana, Milic, Ljiljana, Cuk, Vladica, Hussein, Abdinafic Mohamud, Mccaul, Jeannie, Bertels, Laurie, Pohl, Linda, Arnold, Marion, Mbatani, Nomonde, Oosthuizen, Pj, Rayamajhi, Shreya, Vosloo, Susan, Jooma, Uzair, Landaluce-Olavarria, Aitor, Vázquez-Melero, Alba, Marcos, Alberto, Puerto Puerto, Alejandro, De La Hermosa, Alicia Ruiz, 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Tamburrini, A, Parente, A, Light, A, Diamantopoulou, A, Singh, B, Gurung, B, Frauenfelder, C, Leo, C, Raptis, D, Thakrar, D, Madhuri, T, Tsounaki, E, Garreffa, E, Soggiu, F, Stavrou, G, Ng, H, Tabasi, H, Nasef, H, Kostakis, I, Jeffery, J, Warusavitarne, J, Lund, J, Qurashi, K, Sahnan, K, Tong, K, Orecchia, L, Kaur, M, Zaidi, M, Ganau, M, Curtis, N, Bhatt, N, Machairas, N, Zafar, N, Toma, O, Sarmah, P, Bassuni, M, Davies, J, Shawer, S, Lewis, S, Subramanian, S, Nadeem, U, Njau, A, Tohamy, A, Pakula, A, Simioni, A, Jarvis, B, Skandalakis, G, Hesham, H, Isaiah, I, Villwock, J, Martin, L, Kress, M, Sebelik, M, Lathan, S, Towfigh, S, Holubar, S, Demeester, S, Alshehari, M, Ghabisha, S, Abdulatef, S, Al-Kubati, W, Obadiel, Y, Gots, A, Nakazwe, M, Chipaila, J, Mazingi, D, Shalaby, Mostafa, ElSheikh, Ahmed M., Hamed, Hosam, null, null, Elsheik, Ahmed, Sakr, Ahmad, Fouad, Amgad, Kassem, Amr, Elfeki, Hossam, Madbouly, Khaled, Alzahrani, Khalid H., Marzouk, Khalid, Ali, Mahmoud, Helal, Mohamed Alaa Abdelmoez, Elsorogy, Mohamed, Farid, Mohamed, Di Lorenzo, Nicola, Sileri, Pierpaolo, Wexner, Steven, Khafagy, Wael, Adeyeye, Ademola, El-Hussuna, Alaa, Frontali, Alice, Saklani, Avanish, Lelpo, Benedettao, Molena, Daniela, Pandey, Diwakar, Karbovnichaya, Elena, Pata, Francesco, Van Ramshor, Gabrielle H., Gallo, Gaetano, Spolverato, Gaya, Pellino, Gianluca, Bagaglini, Giulia, Rubio-Perez, Ines, Negoi, Ionut, Frigerio, Isabella, Juloski, Jovan, Ninkovic, Marijana, Franceschilli, Marzia, Azer, Mina, Efetov, Sergey, Ippoliti, Simona, Garoufalia, Zoe, Fazli, Mohammad Rafi, Dogjani, Agron, Cherfa, Harieche Abdennour Abderahim, Omar, Tilioua, Minoldo, Javier, Alvarez Gallesio, José Maria, Quesada, Matias, Bacher, Annica, Kropshofer, Stephan, Ponholzer, Florian, Tesik, Philip, Gehwolf, Philipp, Isci, Sevim, Uranitsch, Stefan, Berchtold, Valeria, Samadov, Elgun, Abualsel, Abdulmenem, Mitul, Ashrarur Rahman, Islam, S. M. Nazmul, Vanlander, Aude, Van Praet, Charles, Van Daele, Elke, Vanommeslaeghe, Hanne, Stijns, Jasper, Abosi-Appeadu, Kessewa, Depuydt, Martijn, Allaeys, Mathias, Yves, Van Nieuwenhove, Colleoni, Ramiro, Slavchev, Mihail, Elbahrawy, Aly, Luc, Jessica G. Y., Milford, Karen, Romic, Ivan, Monti, Alessio, Haydal, Ashraf, Klein, Mads Falk, Ocklind, Miranda E. K., Hadi, Sabah Anwar, Alqasaby, Abdallah, Elganash, Abdelazim, Daibes, Adel Goda Hussein, Elsaied, Adham, Elhattab, Ahmad, Lotfy, Ahmad, Alnashar, Ahmed, Elnour, Ahmed Abd Elbaset Elsayed Abu, Abdelhalim, Ahmed, Abdelhamid, Ahmed, Abdellatif, Ahmed, Abdelmohsen, Ahmed, Abdelrafee, Ahmed, Elhawary, Ahmed Adel, Zidan, Ahmed Azmy, Eleshra, Ahmed, Elkafoury, Ahmed, Ezz, Ahmed, Abdelmomen, Ahmed Ezzat Elghrieb, Elkased, Ahmed Farag, Fawzy, Ahmed, Elkhouly, Ahmed G., Hemidan, Ahmed Gamal Abouelfetouh Ibrahim, Abbas, Ahmed Hosam Eldin Hasan, Ismail, Ahmed Mahmoud Ahmed, Attia, Ahmed Mohamed, Farid, Ahmed Mohammed, Elnakash, Ahmed Mostafa, Negida, Ahmed, Soliman, Ahmed, Taki-Eldin, Ahmed, Albadry, Ali Almahdy Ali, Sanad, Aly, Elbatal, Amira Alsayed Abdelhai, Elgazar, Amr, Saleh, Amr, Fahiem, Andrew, Mohamed, Anwar Yahya A., Nageeb, Ashraf, Elmetwally, Ashraf S., Alkhalegy, Ayman, El-Wakeel, Ayman, Shemes, Ayman, Fadel, Bashir A., Lutfi, Basma Waseem, Ali, Doaa, Abolnasr, Khaled Samir, Gamal, Ehab, Abdallah, Emad, Ahmed, Emad Ali, Salem, Eman Abdalla Mohamed, Hamed, Esmael Ali, Elshikh, Essam, Enad, Farazdaq, Sarhan, Fetoh Alaaeldin Fetoh, Abouelnagah, Galal, Tagg, Gamal Hassan El, Atef, Gehad, Shaker, George Samir Habib, Beshir, Hatem, Zakaria, Hazem M., Barbary, Hesham, Elgendy, Hesham, Sharaf, Hesham, Elnaghi, Hisham, Elghadban, Hosam, Elzayat, Ibrahim, Fakhr, Ibrahim, Sallam, Ibrahim, Abdelmoneim, Ibrahim Tharwat Mohamed, Elnemr, Islam, Zewar, Karem Shahin Mohamed, Elalfy, Khaled, Sabet, Khaled, Mansour, Khaled Yousery Ibrahim, Osman, Khalid Abdalla Abdelgadir, Elgaly, Maher Elesawi Kamel, Shams, Maher, Abozeid, Mahmoud, Mohammed, Mahmoud M., Elkatt, Mahmoud Mohamed, Samaha, Mahmoud Yahia, Mikhael, Marolla Maher Eskander, Khalil, Medhat M. H. A., Alhendawey, Moaaz, Elrefai, Mohamad, Gabr, Mohamed A., Fayed, Mohamed Abdelaziz Mohamed Abdalla M, Abdelmaksoud, Mohamed, Salem, Mohamed Abouelmagd, Mohamed Mohamed, Mohamed Adel, Nabeeh, Mohamed Adel, Elsayed, Mohamed Ahmed Abdelhalim Ahmed, Abdelmonem, Mohamed Ahmed, Ali, Mohamed Anwar Abdel Razik, Eldemery, Mohamed, Elmesery, Mohamed, Fikry, Mohamed, Gharbia, Mohamed, Omar, Mohamed I., Elmoghazy, Mohamed Ibrahim, Ghazala, Mohamed Jomma, Hamed, Mohamed Korayem Fattouh, Metwally, Mohamed, Arnouse, Mohamed Mohamed Hamdy, Amen, Mohamed Mohsen, Amary, Mohamed Mokhtar, Kandel, Mohamed Mosaad, Abuzeid, Mohamed Mostafa, Rabea, Mohamed, Sobh, Mohamed Ramadan, Taman, Mohamed, Fathy, Mohammad, Moustafa, Mohammad Montaser Hassan, Zuhdy, Mohammad, Adel, Mohammed, Alaa, Mohammed, Alawady, Mohammed, Edassy, Mohammed El, Mohammed, Mohammed Mustafa Hassan, Eldesouki, Mohammed Nabil, Salim, Mohammed Said Mahmoud, Sanad, Mohammed, Khalaf, Mohsen George, Henes, Mohsen Michael, Abdelglil, Momen, Mohmmed, Mona Mhmoud, Abdelkhalik, Morsi Mohamed Morsi, Shetiwy, Mosab, Elshazli, Mostafa, Hegazy, Mostafa, Ahmed, Mostafa Mahmoud, Abdelhalim, Mostafa Mohammed, Shahein, Mostafa, Sofan, Mostafa, Hammad, Muhammed Alaa Moukhtar, Ahmad, Mustafa, Milad, Nader, Farouk, Nehal, Eldesouky, Omnia, Mohamed, Omnia Y., Mahadel, Osama Abdel Salam, Gaarour, Osama, Torky, Radwan Abdelsabour, Elhafez, Raheem El-Gohary Abd, Adly, Ramy Magdy, Nageeb, Ramy Mikhael, Hamdi, Salah, Gamal, Sameh, Emile, Sameh Hany, Regal, Samer, Abdelrasheed, Sayed, Elzeftawy, Shady Ahmed, Khashshan, Sohib Mohammed Mohammed, Ashraf, Tamer, Khafagy, Tamer, Nabil, Tamer, Abdelazim, Tarek, Rizk, Tarek Taher, Amr, Wesam, Yousef, Yousef Mohamed, Youssef, Youssef Abdel Aziz, Castaldi, Antonio, Fiore, Antonio, Hasani, Ariola, Mariani, Aurora, Dagorno, Claire, Antonio, D'Alessandro, Izzo, Giuliano, Addari, Giulio, Mangiameli, Giuseppe, Rea, Lo Dico, Pio, Luca, Paci, Marco, Andrea, Police, De Fatico, GSerena, Elvira, Tartaglia, Schuldes, Alejandro Daniel Lira, Rihan, Eslam, Moeslein, Gabriela, Lederhuber, Hans, Botros, Ibram, Jaman, Ismail, Doerner, Johannes, Elseberbihy, John Rezk Hanna, Sherbiny, Kareem El, Ghonim, Mostafa, Mikrish, Amir, Aziz, Mina, Hatm, Mohamed, Archid, Rami, Gendy, Samuel Elkess Morcos, Ahmad, Sufian, Charalabopoulos, Alexandros, Prodromidou, Anastasia, Ioannidis, Argyrios, Mpaili, Eustratia, Boukorou, Garyfallia, Papadopoulos, Georgios, Liakakos, Theodore, Styliani, Vasileiadou, Agrawal, Abhishek, Jain, Amita, Rashid, Arshad, Mehraj, Asif, Brahmachari, Swagata, Lakshmi, Harish Neelamraju, Vishwakarma, Kushagra, Parida, Lalit, Sharma, Meenakshi, Zaieem, Mohammad, Makasarwala, Murtaza, Nittala, Rigved, Kumar, Sanjeev, Vikrantmr, Sharma, Junaid, Sheikh, Khuller, Somyaa, More, Vinal, Ahmed, Abeer Abdul Hameed, Alomieri, Adil, Alhamdany, Arkan Shubber, Del, Muslim Ka, Najm, Ghadah, Lateef, Nawras Falah, Mcnamara, Deborah, Abdelmageed, Mohammed Elkassaby, Majeed, Mudassar, Troci, Albert, Porcu, Alberto, Marano, Alessandra, Di Bartolomeo, Alessandro, Giani, Alessandro, Giardino, Alessandro, Canfora, Alfonso, Balla, Andrea, Barberis, Andrea, Belli, Andrea, Borasi, Andrea, Manetti, Andrea, Mingoli, Andrea, Morini, Andrea, Maurizi, Angela, Marra, Angelo Alessandro, Epifani, Angelo Gabriele, Iossa, Angelo, Parello, Angelo, Guida, Anna, Maffioli, Anna, Scafa, Anthony Kevin, Spinelli, Antonino, Matarangolo, Antonio, Picciariello, Arcangelo, Pirozzi, Brunella, Cirillo, Bruno, Gazia, Carlo, Ratto, Carlo, Foppa, Caterina, Marafante, Chiara, Andrea, Chierici, Tanda, Cinzia, Guerci, Claudio, Don, Cristine, Zigiotto, Daniele, Coniglio, Denise, Sasia, Diego, Visconti, Diego, Altomare, Donato F., Guaitoli, Eleonora, Botteri, Emanuele, Pinotti, Enrico, Martinelli, Fabio, Uggeri, Fabio, Bàmbina, Fabrizio, Falaschi, Federica, Costanzo, Federico, La Torre, Filippo, Milana, Flavio, Abbatini, Francesca, De Lucia, Francesca, Tropeano, Francesca Paola, Colombo, Francesco, Ferrara, Francesco, Litta, Francesco, Carrano, Francesco Maria, Orlando, Francesco, Roscio, Francesco, Selvaggi, Francesco, Giarratano, Gabriella, Pagano, Gianluca, Lisi, Giorgio, Argenio, Giulio, Zancana, Giuseppa, Cavallaro, Giuseppe, Frazzetta, Giuseppe, Mariateresa, Grasso, Sciaudone, Guido, Vella, Ivan, Siragusa, Leandro, Santurro, Letizia, Ferri, Lorenzo, Petagna, Lorenzo, Ferrario, Luca, Pitoni, Ludovica, Pignatelli, Marcello Filograna, Angrisani, Marco, Giugliano, Marco, Inama, Marco, Marino, Marco V., Veltri, Marco, Giuffrida, Maria Carmela, Menna, Maria Paola, Valente, Marina, Rottoli, Matteo, Sacchi, Matteo, Uccelli, Matteo, Rho, Maurizio, Garino, Mauro, Montuori, Mauro, Campanelli, Michela, Zese, Monica, De Falco, Nadia, Cillara, Nicola, Mariani, Nicolò Maria, Tamini, Nicolò, Adorisio, Ottavio, Campennì, Paola, Venturelli, Paolina, Bernante, Paolo, Sapienza, Paolo, Cianci, Pasquale, Marsanic, Patrizia, Lapolla, Pierfrancesco, Tecchio, Piero, Familiari, Pietro, Fransvea, Pietro, Bruzzaniti, Placido, Hassan, Redan, Pirovano, Riccardo, Rimonda, Roberto, Di Saverio, Salomone, Di Carlo, Sara, Perra, Teresa, Campagnaro, Tommaso, Testa, Valentina, Andriola, Valeria, Grappelli, Virgilio Michael Ambrosi, Capizzi, Vita, Chiarella, Vito, Bellato, Vittoria, Yanaga, Katsuhiko, Farouk, Mohamed, Uraiqat, Ahmad, Almasri, Mahmoud, Nabwana, Ambrose, Siboe, Mark M. W., W, Njoroge P., Njoroge, Githu, Ilkul, Jh., Obure, Ralph Ombati, Palkhi, Yusuf, Alkhayat, Ali, Ali, Ali Sayed, Malek, Amgad Nashaat Abdel, Abdelsayed, Emad Fahim, Zahra, Tarek, Ayoub, Larissa, Sleilati, Fadi, Aoun, Rany, Algatanesh, Nassib, Fieturi, Nura Ahmed, Ng, Jen Siang, Díaz, Andrés Vega, Duran, Erik Efrain Sosa, Guerrero, José Eaazim Flores, Jasso, Manuel Meza, Flores, Manuel SSalas, Felix, Marcos José Serrato, Angulo, Victor Manuel Pinto, Mejdane, Abdelhadi, Aitali, Abdelmounaim, Amal, Benzakour, Zentar, Aziz, Bensaad, Ahmed, Yacir, El Alami, Jawad, Fassi Fihri Mohamed, Rachid, Mohamed Ghassane, Maliki-Alaoui, Mohamed, Ouadii, Mouaqit, Mohammed, Ouazni, Thein, Nyan, Koirala, Dinesh Prasad, Hilling, Denise, Pouwels, Sjaak, Okunlola, Abiodun Idowu, Adejumo, Adeyinka, Akinmade, Akinola, Shittu, Asimiyu Adekunle, Oluyomi, Ayodele Samuel, Abiodun, Azeez Lateef, Lawal, Bashir, Odion, Clement, Popoola, Ademola, Jolayemi, Edward, Shomoye, El-Zaki, Wuraola, Funmilola Olanike, Eke, Grace, Abiyere, Henry, Oluwasuyi, Ige, George, Ihediwa, Njokanma, Iloba Gabriel, Aremu, Isiaka, Dare, Julius Kolajo, Abdur-Rahman, Lukman, Ahmad, Misbahu Haruna, Oludara, Mobolaji Adewale, Mohammad, Mohammad Aminu, Adeoluwa, Ojajuni, Situ, Oladele, Agbonrofo, Peter, Kewulere, Raji Taofiq, Aliyu, Yakubu, Adebowale, Yusuf, Galala, Ahmed, Rao, Satish, Waleed, Aasma, Inam, Aatif, Shaikh, Abdul Razaque, Qureshi, Ahmad Uzair, Muhammad, Aneeqah Din, Ahmed, Arooj, Kerawala, Asad Ali, Aslam, Mohammad, Mehr, Asma, Javed, Ayesha, Ahmad, Farooq, Majid, Haroon Javaid, Ahmed, Hassan, Daudi, Irfan, Akhtar, Khalid, Niaz, Khurram, Anwer, Mariyah, Amir, Mohammed, Hanif, Muhammad Amir, Asif, Muhammad, Raza, Muhammad Asif, Khokhar, Muhammad Imran, Jameel, Muhammad Khurram, Nasir, Muhammad, Shafique, Muhammad Salman, Ateeb, Mujammad, Nadeem, Munawar, Shah, Rahmat Ullah, Waqar, Shahzad Hussain, Shah, Shahzad Alam, Waseem, Talat, Ghafoor, Tariq, Fatima, Tauseef, Bashir, Umar, Gonzales, Erick Ivan Huaman, Ruiz, Luis Angel Garcia, Freitas, Carla, De Sousa, Xavier, Al-Bahrani, Ahmed, Portela, Carlos Antonio Sanchez, Elgazar, Elsayed Aly, Robles, Eloy Morasen, Khan, Irfan Jan, Jarboa, Lutfi, Khawar, Mahwish, Echevarria, Miguel Jose Pinto, Bashah, Moataz M., Dawdi, Salahaldeen, Musthafa, Shameel, Ali, Syed Muhammad, Ciubotaru, Cezar, Bonci, Eduard-Alexandru, Muresan, Mihai-Stefan, Bogdan, Stoica, Ioan, Tanase, Zubayraeva, Albina, Derinov, Aleksandr, Zakharenko, Alexander, Novikova, Anastasia, Bashlachev, Andrey, Kaldarov, Ayrat, Stanislav, Berelavichus, Gorin, David, Puzenko, Dmitriy, Kazachenko, Ekaterina, Ashimov, Erkin, Medkova, Iuliia, Ignatov, Ivan, Sergeevich, Kochetkov Viktor, Sidorova, Lyudmila, Kiselev, Michail, Danilov, Michail, Aleksandr, Ogoreltsev, Rodimov, Sergey, Garmanovs, Tatiana, Kitsenko, Yury, Valery, Nekoval, Japhet, Ntezamizero, Sibiany, Abdulrahman, Saadeldin, Abdelhalim, Abuosba, Abdelrahman, Alawadhi, Abdulbari Mohammed, Alharbi, Abdulhamid, Althumali, Abdullah, Alghuliga, Abdullah, Alotaibi, Abdullah, Abduraboh, Abdullah Fayez, Kateb, Abdullah, Sindy, Abdullah, Al Eisa, Abdulmohsen, Alotaibi, Abdulrahman, Almulhim, Abdulrhman, Aljawhari, Adel Ali, Abozeid, Ahmad Mahmoud, Saad, Ahmad, Alqarni, Ahmed, Alwan, Ahmed, Alwusaibie, Ahmed, Bafaraj, Ahmed, Eldeeb, Ahmed, Tarabay, Ahmed, Mohammed, Mahfoudh, Alhedaithy, Alhanouf, Almaghrabi, Alhassan Hesham, Abed, Ali Ibrahim Eldawy, Abdullah, Alqahtani Ali, Semilan, Anmar, Farag, Mohamed, Khudhayr, Essa, Hussain, Marwah, Abbas, Ghanem, Alqudaihi, Heba, Abualnaja, Yousra, Shaheen, Abelnasser, Mubarak, Ashraf Abdelazeem Mohamed, Ali, Bandar Idrees A., Alhazmi, Barrag, Hijazi, Bilal Ahmed, Abdulrahman, Chadi, Oyedepo, Charles Olajide, Alzamel, Heythem, Tairab, Elsanousi Ibrahim Sabir, Alsuwaimel, Munir A., Hejazi, Soha, Alnoqaidan, Emad, Alhussien, Fade Ahmed, Jallad, Fadi Sami, Khadwardi, Faisal, Alghamdi, Faisal Saleh, Haddad, Feras, Sauri, Fozan, Alafghani, Haitham, Alfalah, Haitham, Gad, Hamada, Aboelmagid, Hamdy Haggag Ebrahim, Ibrahim, Hamed, Elzayady, Hany M., Sharafeldin, Hatem Abdelrahman Ahmed, Sembawa, Hatem A., Alabbas, Haytham, Abbas, Hazem, Elgamal, Hesham, Alawfi, Homoud, Al-Sadery, Humood, Abdelmotaleb, Hussien Ali, Al Hassn, Ibrahim, Mudawi, Ishag M., Nekhala, Islam, Elsanhoury, Kareem, Said, Khalid Babieker, Albeshri, Khalid A., Albahooth, Khalid, Mohammed, Khalid Fathelrahman Bakier, Asar, Khalid Mohammad Ibrahim, Osman, Luqman, Alzamanan, Mahdi, Alnabarawi, Mahmoud, Althobaiti, Majid, Elsayed, Mohamed Abdelmoneim, Al Naeb, Mohamed, Hassan, Mohamed Salah Eldin, Abdelhamid, Mohamed Sayed, Alyami, Mohammad, Mirza, Mohammad Amin, Sayouh, Mohammad, Alkhayat, Mohammed Amer, Basendowah, Mohammed, Ghunaim, Mohammed, Alhussaini, Mohammed Khalid, Khoj, Mohammed, Sbaih, Mohammed, Saeed, Muhammad Ahmad, Ali, Muhammad Zulfiqar, Abdelaziz, Nabil Yassin Tammam, Malibary, Nadim, Abdo, Nael, Amer, Nasser Mohammed, Al Turki, Neamat Ahmed Ali, Durayb, Norah, Yassin, Nouf, Akeel, Nouf, Larbi, Noureddine, Alsallum, Ofays, Suliman, Omar AAbu, Elsherbiny, Osama, Abusalem, Osama, Albalawi, Ibrahim Altedlawi, Abutalib, Raid Abdullah, Alarabi, Rayan, Khan, Roaa Ghazi, Alazzam, Saleh, Alghamdi, Saleh, Alsawat, Salem, Salim, Sami, Alshukr, Sarah, Alzahrani, Saud, Golea, Smain, Alowairdhi, Tumadher, Salman, Usama, Abusiam, Wael, Abualkhair, Wael, Saber, Wael, Tashkandi, Wail, Alhazmi, Waleed, Tashkandi, Waleed, Yassine, Wassim Abou, Alshabi, Yaser Ahmad, Ibrahim, Yaser, Shahin, Yasser, Ibrahim, Yassin, Aljathlany, Yousef, Alnahas, Yousef, Alrashidi, Yousef, Wali, Zubair, Ndong, Abdourahmane, Ba, Mamadou, Faye, Papa Mamadou, Arbutina, Dragana, Milic, Ljiljana, Cuk, Vladica, Hussein, Abdinafic Mohamud, Mccaul, Jeannie, Bertels, Laurie, Pohl, Linda, Arnold, Marion, Mbatani, Nomonde, Oosthuizen, Pj, Rayamajhi, Shreya, Vosloo, Susan, Jooma, Uzair, Landaluce-Olavarria, Aitor, Vázquez-Melero, Alba, Marcos, Alberto, Puerto Puerto, Alejandro, De La Hermosa, Alicia Ruiz, Senent-Boza, Ana, Ugarte-Sierra, Bakarne, Montalbán, Beatriz Cros, Martin-Perez, Beatriz, Gomez, Caroina Gonzalez, Colás-Ruiz, Enrique, Santos, Esther Garcia, Senra, Fatima, Mora-Guzmán, Ismael, Dziakova, Jana, Díaz, Jeancarlos J. Trujillo, Silva, Jesús, Laina, Juan Luis Blas, Tallon-Aguilar, Luis, Di Martino, Marcello, Chacón, Mario Franco, Frasson, Matteo, Calvo, Mikel Prieto, Millan, Monica, Tejedoe, Patricia, Pérez-Bertólez, Sonia, Turrado-Rodríguez, Víctor, Elsanosi, Abdelrhman Azhari Mohammed, Abdalbakheet, Duaa, Ahmed, Mohamed, Salim, Omer El Faroug H., Youssef, Mohamed, Barbon, Carlotta, Bouchrika, Amal, Maghrebi, Houcine, Loukil, Issam, Yildiz, Alp, Dursun, Ayberk, Gulcu, Baris, Calik, Bulent, Eral, Burak, Yeşilyurt, Değercan, Yakar, Fatih, Akin, Furkan Atakan, Kilinc, Gizem, Uslu, Gülberk, Tuncer, Korhan, Koc, Mehmet Ali, Leventoğlu, Sezai, Sokmen, Selman, Atici, Semra Demirli, Kaya, Tayfun, Dere, Ümit Akın, Kırmızı, Yasemin, Ssenono, Kavuma Daniel, Lule, Herman, Mbiine, Ronald, Hamza, Ahmed, Ali, Shabeer, Peediyakkal, Saidalavi Padinhare, Varma, Gopala Pillay, Mussa, Haidar Aal, Al-Masari, Hayder Makki, Shehata, Mina, Seiam, Moham, Aziz, Muhammad Akram Abdul, Nimir, Nessrein, Khare, Ritu, Rashid, Shahid, Kazim, Shuiab, Gondal, Zafar, Sherif, Ahmed Elshawadfy, Ghanem, Ahmed, Helmy, Ahmed Hazem I., Ibrahim, Ahmed, Elshaer, Ahmed Mohammed, Marzouk, Ahmed Msm, Tamburrini, Alessandro Paolo, Parente, Alessandro, Light, Alexander, Diamantopoulou, Angela, Singh, Baljit, Gurung, Binay, Frauenfelder, Claire, Leo, Cosimo Alex, Raptis, Dimitri, Thakrar, Dixa, Madhuri, Thumuluru Kavitha, Tsounaki, Efthymia, Garreffa, Emanuele, Soggiu, Fiammetta, Stavrou, George, Ng, Hwei Jene, Tabasi, Hani, Nasef, Hazem, Kostakis, Ioannis D., Jeffery, James, Warusavitarne, Janindra, Lund, Jon, Qurashi, Kamran, Sahnan, Kapil, Tong, Kin Seng, Orecchia, Luca, Kaur, Mandeep, Zaidi, Mariam, Ganau, Mario, Hassan, Mohamed Ali Gad, Curtis, Nathan, Bhatt, Nikita, Machairas, Nikolaos, Zafar, Noman, Toma, Omar, Sarmah, Panchali, Bassuni, Majid, Davies, Justin, Shawer, Sami, Shawer, Sherif, Lewis, Sophia, Subramanian, Sivaraman, Ahmad, Suhaib, Nadeem, Uqba, Njau, Aidan, Tohamy, Aley Eldin, Pakula, Andrea M., Simioni, Andrea, Jarvis, Bennie L., Skandalakis, Georgios P., Hesham, Hosai Todd, Isaiah, Isaac A., Villwock, Jennifer, Martin, Linda W., Kress, Melissa, Sebelik, Merry, Lathan, Sanaz, Towfigh, Shirin, Holubar, Stefan D., Demeester, Steve, Alshehari, Mohammed Mohammed Hasan, Ghabisha, Saif Ali, Abdulatef, Shehab Ahmed Ali, Al-Kubati, Waheeb, Obadiel, Yasser Abdurabo, Gots, Alexander, Nakazwe, Mildred, Chipaila, Jackson, and Mazingi, Dennis
- Abstract
BackgroundSARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice.MethodsThis is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure.ResultsNine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout.There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management.ResultsNine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout.There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits
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- 2024
4. Histologic and Clinical Factors Associated with Kidney Outcomes in IgA Vasculitis Nephritis
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Barbour, S, Coppo, R, Er, L, Pillebout, E, Russo, M, Alpers, C, Fogo, A, Ferrario, F, Jennette, J, Roberts, I, Cook, H, Ding, J, Su, B, Zhong, X, Fervenza, F, Zand, L, Peruzzi, L, Lucchetti, L, Katafuchi, R, Shima, Y, Yoshikawa, N, Ichikawa, D, Suzuki, Y, Murer, L, Wyatt, R, Nelson, R, Narus, J, Wenderfer, S, Geetha, D, Daugas, E, Monteiro, R, Nakatani, S, Mastrangelo, A, Nuutinen, M, Koskela, M, Weber, L, Hackl, A, Pohl, M, Pecoraro, C, Tsuboi, N, Yokoo, T, Takafumi, I, Fujimoto, S, Conti, G, Santoro, D, Materassi, M, Zhang, H, Shi, S, Liu, Z, Tesar, V, Maixnerova, D, Avila-Casado, C, Bajema, I, Barreca, A, Becker, J, Comstock, J, Cornea, V, Eldin, K, Hernandez, L, Hou, J, Joh, K, Lin, M, Messias, N, Muda, A, Pagni, F, Diomedi-Camassei, F, Tokola, H, D’Armiento, M, Seidl, M, Rosenberg, A, Sannier, A, Soares, M, Wang, S, Zeng, C, Haas, M, Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S. D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T, Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, D’Armiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, Haas, Mark, Barbour, S, Coppo, R, Er, L, Pillebout, E, Russo, M, Alpers, C, Fogo, A, Ferrario, F, Jennette, J, Roberts, I, Cook, H, Ding, J, Su, B, Zhong, X, Fervenza, F, Zand, L, Peruzzi, L, Lucchetti, L, Katafuchi, R, Shima, Y, Yoshikawa, N, Ichikawa, D, Suzuki, Y, Murer, L, Wyatt, R, Nelson, R, Narus, J, Wenderfer, S, Geetha, D, Daugas, E, Monteiro, R, Nakatani, S, Mastrangelo, A, Nuutinen, M, Koskela, M, Weber, L, Hackl, A, Pohl, M, Pecoraro, C, Tsuboi, N, Yokoo, T, Takafumi, I, Fujimoto, S, Conti, G, Santoro, D, Materassi, M, Zhang, H, Shi, S, Liu, Z, Tesar, V, Maixnerova, D, Avila-Casado, C, Bajema, I, Barreca, A, Becker, J, Comstock, J, Cornea, V, Eldin, K, Hernandez, L, Hou, J, Joh, K, Lin, M, Messias, N, Muda, A, Pagni, F, Diomedi-Camassei, F, Tokola, H, D’Armiento, M, Seidl, M, Rosenberg, A, Sannier, A, Soares, M, Wang, S, Zeng, C, Haas, M, Barbour, Sean J., Coppo, Rosanna, Er, Lee, Pillebout, Evangeline, Russo, Maria Luisa, Alpers, Charles E., Fogo, Agnes B., Ferrario, Franco, Jennette, J. Charles, Roberts, Ian S. D., Cook, H. Terence, Ding, Jie, Su, Baige, Zhong, Xuhui, Fervenza, Fernando C., Zand, Ladan, Peruzzi, Licia, Lucchetti, Laura, Katafuchi, Ritsuko, Shima, Yuko, Yoshikawa, Norishige, Ichikawa, Daisuke, Suzuki, Yusuke, Murer, Luisa, Wyatt, Robert J., Nelson, Raoul D., Narus, JoAnn H., Wenderfer, Scott, Geetha, Duvuru, Daugas, Eric, Monteiro, Renato C., Nakatani, Shinya, Mastrangelo, Antonio, Nuutinen, Matti, Koskela, Mikael, Weber, Lutz T, Hackl, Agnes, Pohl, Martin, Pecoraro, Carmine, Tsuboi, Nobuo, Yokoo, Takashi, Takafumi, Ito, Fujimoto, Shouichi, Conti, Giovanni, Santoro, Domenico, Materassi, Marco, Zhang, Hong, Shi, Sufang, Liu, Zhi-Hong, Tesar, Vladimir, Maixnerova, Dita, Avila-Casado, Carmen, Bajema, Ingeborg, Barreca, Antonella, Becker, Jan U., Comstock, Jessica M., Cornea, Virgilius, Eldin, Karen, Hernandez, Loren Herrera, Hou, Jean, Joh, Kensuke, Lin, Mercury, Messias, Nidia, Muda, Andrea Onetti, Pagni, Fabio, Diomedi-Camassei, Francesca, Tokola, Heikki, D’Armiento, Maria, Seidl, Maximilian, Rosenberg, Avi, Sannier, Aurélie, Soares, Maria Fernanda, Wang, Suxia, Zeng, Caihong, and Haas, Mark
- Abstract
BACKGROUND: Nephritis is a common manifestation of IgA vasculitis and is morphologically indistinguishable from IgA nephropathy. While MEST-C scores are predictive of kidney outcomes in IgA nephropathy, their value in IgA vasculitis nephritis has not been investigated in large multiethnic cohorts. METHODS: Biopsies from 262 children and 99 adults with IgA vasculitis nephritis ( N =361) from 23 centers in North America, Europe, and Asia were independently scored by three pathologists. MEST-C scores were assessed for correlation with eGFR/proteinuria at biopsy. Because most patients ( N =309, 86%) received immunosuppression, risk factors for outcomes were evaluated in this group using latent class mixed models to identify classes of eGFR trajectories over a median follow-up of 2.7 years (interquartile range, 1.2-5.1). Clinical and histologic parameters associated with each class were determined using logistic regression. RESULTS: M, E, T, and C scores were correlated with either eGFR or proteinuria at biopsy. Two classes were identified by latent class mixed model, one with initial improvement in eGFR followed by a late decline (class 1, N =91) and another with stable eGFR (class 2, N =218). Class 1 was associated with a higher risk of an established kidney outcome (time to ≥30% decline in eGFR or kidney failure; hazard ratio, 5.84; 95% confidence interval, 2.37 to 14.4). Among MEST-C scores, only E1 was associated with class 1 by multivariable analysis. Other factors associated with class 1 were age 18 years and younger, male sex, lower eGFR at biopsy, and extrarenal noncutaneous disease. Fibrous crescents without active changes were associated with class 2. CONCLUSIONS: Kidney outcome in patients with biopsied IgA vasculitis nephritis treated with immunosuppression was determined by clinical risk factors and endocapillary hypercellularity (E1) and fibrous crescents, which are features that are not part of the International Study of Diseases of Children classificatio
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- 2024
5. Investigating the link between nutritional selenium and immunity in rainbow trout (Oncorhynchus mykiss)
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Pohl, Moritz Arne Nessim, Secombes, Christopher J., Martin, Samuel A. M., and Sweetman, John
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590 ,Rainbow trout ,Selenoproteins ,Selenium ,Immune response ,Genomes - Abstract
This thesis investigated the effects of selenium supplementation on the immune response in rainbow trout (Oncorhynchus mykiss). Therefore, as a start into selenium research, salmonid genomes were screened for selenoproteins with suggested roles in immunity that evaded previous automated annotation. Two salmonid-specific selenoprotein P genes were discovered, cloned, characterised and specific qPCR primers designed and validated. Next, cell culture experiments were performed to investigate the effects of Se supplementation on selenoprotein and immune gene expression in vitro. Several Se concentrations were tested and an optimal level for alteration of selenoprotein transcripts determined. This selenium supplementation level was then combined with immune stimulants to investigate the effects of selenoprotein expression in response to immune activation and immune gene expression following Se supplementation. Se supplementation exhibited a cell type-specific and context-dependent effect on the immune gene expression and was capable to induce or suppress the expression of several cytokines as a result of Se supplementation in vitro. The effects of supranutritional Se supplementation were then examined in vivo, following bacterial infection, injection vaccination and oral immunisation in three distinct in vivo trials. These experiments were designed to investigate the effects of selenium supplemented fish in comparison to unsupplemented fish in either unstimulated control groups (selenium effect) or immune activated groups (selenium*immunity). The Se supplementation was achieved by feeding a diet with Sel-Plex inclusion to 50 % of the fish in the experiment. Sel-Plex a dietary selenium supplement from Alltech Ltd and is comprised of mainly organic selenium derived from yeast cultured in Se enriched media. In the first trial, a bacterial infection with Aeromonas salmonicida was induced by intraperitoneal injection of the pathogen after 5 weeks of feeding the Se supplement. Then the innate immune response was examined by transcriptomic analysis of immune molecules and the selenoproteome. The results showed a significantly dampened cytokine induction in the head kidney of the Se supplemented group that indicated a reduced level of inflammation and suggested a swifter tuning of the immune response towards infection resolution prompted by dietary Se. This was accompanied by the induction of selenoprotein expression by infection in the same tissue, although not significantly different between diet groups. In the injection vaccination trial, an unadjuvanted experimental A. salmonicida bacterin vaccine was utilised that was specifically prepared for this purpose. The fish were vaccinated after 5 weeks of Se supplementation by injection of the vaccine. The immune response was examined by gene expression studies and revealed a more pronounced induction of cytokines in the liver of Se supplemented fish compared to the control group. Selenoproteins were equally induced for both groups in this tissue. Blood samples that were taken 4, 8 and 12 weeks post immunisation revealed significantly elevated serum levels of specific IgM in all vaccinated groups. The Se supplemented fish showed a significantly higher IgM titre in an analysis combining the three sample points. This finding could be significant during a disease challenge when a humoral antibody-directed immune response contributes to pathogen clearance. In the third trial, a primary immunisation with a commercial booster vaccine was attempted. This investigated the antigen uptake in the gut and any Se effects on this process. After 5 weeks of dietary Se supplementation the fish were orally immunised. Gene expression studies were performed on a subset of the fish that showed no marked differences between diet groups post immunisation. A distinct immune reaction was not induced by the vaccine. A subset of the fish was kept on the respective diets and challenged with a pathogenic strain of Yersinia ruckeri 53 days post completion of immunisation. No significant differences in survival between unvaccinated and vaccinated groups were found. Also, the diet groups showed no significant differences in level of protection. The orally administered primary vaccination did not protect from disease in a subsequent pathogen challenge which suggested an insufficient immune activation, as indicated by the gene expression studies. In this model, selenium supplementation did not enhance the antigen-induced immune response in vaccinated fish or level of disease protection in unvaccinated fish. Taken together, supra-nutritional Se supplementation of rainbow trout was shown to modulate the cytokine expression during a bacterial infection with A. salmonicida and enhanced specific serum IgM titres after injection vaccination with an A. salmonicida bacterin.
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- 2019
6. The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases
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Pohl, Franziska, Kong, Thoo Lin (Paul), Goua, Marie, and Bermano, Giovanna
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616.8 ,Rapeseed extract ,Neurodegenerative diseases ,Biochemical analysis - Abstract
Rapeseed pomace (RSP) is the waste/by-product obtained after edible oil production from Brassica napus and is currently used as animal feed. In an attempt to revalorize this by-product as a potential nutraceutical for the treatment or prevention of neurodegenerative disease, this project aimed to determine (i) a suitable extraction technique, (ii) the phytochemical composition and in vitro activity of the extract, in relation to neuroprotective properties, (iii) the neuroprotective potential of the extract in a cellular model (SH-SY5Y neuroblastoma cells) and (iv) the extract's potential to prevent/treat neurodegenerative disease in one Machado-Joseph disease (MJD) and three Parkinson's disease (PD) C. elegans (nematode) models. To achieve this aim at the start of the project, three extraction techniques (i.e. Soxhlet, ultrasonic assisted and accelerated solvent extraction) were employed, using a solvent mixture of ethanol and water (95:5) on the RSP samples obtained from the north east of Scotland. Based on the chemical composition of the extracts and their antioxidant properties, Soxhlet extraction was revealed as the most promising and practical extraction technique. Bulk extraction was carried out, to obtain enough RSP extract for the duration of the project. Thereafter, the composition of the extract was further investigated, to show sinapine to be the most abundant secondary metabolite, together with other phenolic acids, such as sinapic, ferulic, caffeic and syringic acid. The final extract showed in vitro antioxidant and acetylcholinesterase inhibition activity, the potential to protect plasmid DNA from oxidative damage, copper ion chelating potential and the inhibition of self-mediated β-amyloid (1-42) aggregation. The latter in vitro characteristics and properties could be beneficial for the protection of neurons from oxidative stress induced degeneration. In the SH-SY5Y neuroblastoma cell line, the RSP extract was found to be non-toxic up to a concentration of 1.5 mg/mL. Subsequent cellular studies using 1 mg/mL or less of the RSP extract, showed its ability to protect the cells from reactive oxygen species (ROS) and oxidative DNA strand breakage induced by hydrogen peroxide. In addition, using protein array technology, the RSP extract was able to down regulate cell stress associated proteins SIRT2 and SOD2. In the C. elegans nematode model, the RSP extract showed no toxicity up to 5 mg/mL. The RSP extract was able to improve the disease phenotype in the MJD model (motility deficiency) as well as in all three PD models (dopaminergic neuronal loss). This improvement was at least partially dependent on the activation of the antioxidant gene glutathione-s-transferase (gst-4) in C. elegans. Overall, the RSP extract showed very positive in vitro characteristics and valuable in vivo effects in 4 disease C. elegans models, thus warranting further detailed studies on the use of RSP extract to help prevent and/or treat neurodegenerative diseases.
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- 2019
7. Relationship between semiotic representations and student performance in the context of refraction
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Linder, Cedric, Bruun, Jesper, Pohl, Arvid, Priemer, Burkhard, Linder, Cedric, Bruun, Jesper, Pohl, Arvid, and Priemer, Burkhard
- Abstract
Social semiotic discussions about the role played by representations in effective teaching and learning in areas such as physics have led to theoretical proposals that have a strong common thread: in order to acquire an appropriate understanding of a particular object of learning, access to the disciplinary relevance aspects in the representations used calls for the attainment of representational competence across a particular critical constellation of systematically used semiotic resources (which are referred to as modes, see more on this later). However, an affirming empirical investigation into the relationship between a particular object of learning and different representational formulations, particularly with large numbers of students, is missing in the literature, especially in the context of university -level physics education. To start to address, this research shortfall the positioning for this article is that such studies need to embrace the complexities of student thinking and application of knowledge. To achieve this, both factor and network analyses were used. Even though both approaches are grounded in different frameworks, for the task at hand, both approaches are useful for analyzing clustering dynamics within the responses of a large number of participants. Both also facilitate an exploration of how such clusters may relate to the semiotic resource formulation of a representation. The data were obtained from a questionnaire given to 1368 students drawn from 12 universities across 7 countries. The questionnaire deals with the refraction of light in introductorylevel physics and involves asking students to give their best prediction of the relative visual positioning of images and objects in different semiotically constituted situations. The results of both approaches revealed no one-to-one relationship between a particular representational formulation and a particular cluster of student responses. The factor analysis used correct answer responses to
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- 2024
- Full Text
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8. Army ant middens – Home and nursery of a diverse beetle fauna
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Beeren, Christoph von, Pohl, Sebastian, Fikáček, Martin, Kleinfelder, Stephan, Tishechkin, Alexey K., Yamamoto, Shûhei, Chani‐Posse, Mariana, Żyła, Dagmara, Tokareva, Alexandra, Maruyama, Munetoshi, Hall, W. Eugene, Sandoval, Liliana P., Kronauer, Daniel J. C., Beeren, Christoph von, Pohl, Sebastian, Fikáček, Martin, Kleinfelder, Stephan, Tishechkin, Alexey K., Yamamoto, Shûhei, Chani‐Posse, Mariana, Żyła, Dagmara, Tokareva, Alexandra, Maruyama, Munetoshi, Hall, W. Eugene, Sandoval, Liliana P., and Kronauer, Daniel J. C.
- Abstract
Army ants provide nourishment to a large variety of animals. This includes birds that feed on animals flushed out by army ant raids, symbiotic arthropods that consume the ants' prey or their brood, and other arthropods that scavenge on army ant refuse deposits. The latter have not received much attention, and the few published studies lack detailed species identifications. Here we provide a first systematic inventory of the beetle fauna associated with refuse deposits of Eciton army ants, with a focus on Eciton burchellii. We collected 8364 adult beetles, 511 larvae, and 24 eggs from 34 deposits at La Selva Biological Station, Costa Rica. We used a combination of DNA barcoding and morphology to identify a subset of 436 specimens to species level. The samples included several new species, and we here formally describe two water scavenger beetles (Hydrophilidae). Refuse deposits harbored a diverse beetle fauna. The identified subset consisted of 91 beetle species from 12 families, with rove beetles being the most abundant and diverse visitors. Of the 85 species found with E. burchellii, 50 species were collected from only one or two refuse deposits. Conversely, seven species were found in 10 or more refuse deposits, indicating a certain level of habitat specialization. We matched adults and immatures for 22 beetle species via DNA barcodes, demonstrating that army ant middens also serve as a beetle nursery. The present survey highlights the significant ecological function of army ants as promoters of biodiversity and their status as keystone species in tropical rainforests.
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- 2024
9. Enhancing composite crushing prediction with strain-rate-dependent numerical models
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Drechsler, Klaus (Prof. Dr.), Drechsler, Klaus (Prof. Dr.);Catalanotti, Giuseppe (Prof. Dr.), Pohl, Christian Dieter, Drechsler, Klaus (Prof. Dr.), Drechsler, Klaus (Prof. Dr.);Catalanotti, Giuseppe (Prof. Dr.), and Pohl, Christian Dieter
- Abstract
In this thesis, composite crushing was studied with specimens of increasing complexity in experiments and numerical simulations. Physically motivated discrete-ply models considering strain rate effects were shown to be essential for the predictive prognoses of crushing under high loading rates. However, stacked-laminate models exhibited promising results at reduced numerical costs. Further experimental and numerical studies of composites under strain rates above 5,000 1/s are recommended., In dieser Arbeit wurde Crushing von Composites an Proben zunehmender Komplexität experimentell und numerisch untersucht. Es wurde gezeigt, dass physikalisch motivierte Einzelschichtmodelle, die Dehnrateneffekte berücksichtigen, für die Prognose hochdynamischen Crushings von entscheidender Bedeutung sind. Jedoch zeigten geschichtete Laminatmodelle vielversprechende Ergebnisse bei geringerem Berechnungsaufwand. Weitere Untersuchungen von Composites unter Dehnraten über 5.000 1/s werden empfohlen.
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- 2024
10. Roadmap towards safe and sustainable advanced and innovative materials. (Outlook for 2024-2030)
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Cassee, Flemming R., Bleeker, Eric A.J., Durand, Cyrille, Exner, Thomas, Falk, Andreas, Friedrichs, Steffi, Heunisch, Elisabeth, Himly, Martin, Hofer, Sabine, Hofstätter, Norbert, Hristozov, Danail, Nymark, Penny, Pohl, Anna, Soeteman-Hernández, Lya G., Suarez-Merino, Blanca, Valsami-Jones, Eugenia, Groenewold, Monique, Cassee, Flemming R., Bleeker, Eric A.J., Durand, Cyrille, Exner, Thomas, Falk, Andreas, Friedrichs, Steffi, Heunisch, Elisabeth, Himly, Martin, Hofer, Sabine, Hofstätter, Norbert, Hristozov, Danail, Nymark, Penny, Pohl, Anna, Soeteman-Hernández, Lya G., Suarez-Merino, Blanca, Valsami-Jones, Eugenia, and Groenewold, Monique
- Abstract
The adoption of innovative advanced materials holds vast potential, contingent upon addressing safety and sustainability concerns. The European Commission advocates the integration of Safe and Sustainable by Design (SSbD) principles early in the innovation process to streamline market introduction and mitigate costs. Within this framework, encompassing ecological, social, and economic factors is paramount. The NanoSafety Cluster (NSC) delineates key safety and sustainability areas, pinpointing unresolved issues and research gaps to steer the development of safe(r) materials. Leveraging FAIR data management and integration, alongside the alignment of regulatory aspects, fosters informed decision-making and innovation. Integrating circularity and sustainability mandates clear guidance, ensuring responsible innovation at every stage. Collaboration among stakeholders, anticipation of regulatory demands, and a commitment to sustainability are pivotal for translating SSbD into tangible advancements. Harmonizing standards and test guidelines, along with regulatory preparedness through an exchange platform, is imperative for governance and market readiness. By adhering to these principles, the effective and sustainable deployment of innovative materials can be realized, propelling positive transformation and societal acceptance.
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- 2024
11. Hindsight bias and the practice of arrests in Poland
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Janusz-Pohl, Barbara, Wawrzyńczak, Michał, Janusz-Pohl, Barbara, and Wawrzyńczak, Michał
- Abstract
This comparative study deals with the various forms of arrest in the Polish criminal law system. The authors used the dogmatic-legal and comparative methods, and applied the empirical method in several case studies. The background of the considerations is the proposal of a typology of procedural arrests, based on the Code of Criminal Procedure and non-procedural arrests, based on special laws. The main subject of consideration is the risk of instrumentalization of arrest, which can be considered at several levels: structural, concerning the abuse of the grounds for arrest, and peri-arrest activities (such as informing and questioning the detained person). Within these are three risks of instrumentalization: abuse of the law sensu stricto, sensu largo, and violation of law. Hindsight bias helps to understand the risk of the instrumental application of the law. If the law poses a severe risk of instrumentalization, it must be changed. The authors conclude that the Polish legislator ignores these risks until the law is misapplied. Instead, a proper diagnosis of risks should lead to legislative amendments. The authors propose that mandatory recordings of actions should be introduced. To further strengthen the right to defence, the authors propose changes to the sequence of actions (peri-arrest activities), especially regarding the hearing of the arrested person. Moreover, there is doubt about the standards for applying non-procedural arrests, where the general rules of the Code of Criminal Procedure should apply. Still, the diverse status of the bodies authorized to carry out such actions is a factor that increases the risk of instrumentalization., This comparative study deals with the various forms of arrest in the Polish criminal law system. The authors used the dogmatic-legal and comparative methods, and applied the empirical method in several case studies. The background of the considerations is the proposal of a typology of procedural arrests, based on the Code of Criminal Procedure and non-procedural arrests, based on special laws. The main subject of consideration is the risk of instrumentalization of arrest, which can be considered at several levels: structural, concerning the abuse of the grounds for arrest, and peri-arrest activities (such as informing and questioning the detained person). Within these are three risks of instrumentalization: abuse of the law sensu stricto, sensu largo, and violation of law. Hindsight bias helps to understand the risk of the instrumental application of the law. If the law poses a severe risk of instrumentalization, it must be changed. The authors conclude that the Polish legislator ignores these risks until the law is misapplied. Instead, a proper diagnosis of risks should lead to legislative amendments. The authors propose that mandatory recordings of actions should be introduced. To further strengthen the right to defence, the authors propose changes to the sequence of actions (peri-arrest activities), especially regarding the hearing of the arrested person. Moreover, there is doubt about the standards for applying non-procedural arrests, where the general rules of the Code of Criminal Procedure should apply. Still, the diverse status of the bodies authorized to carry out such actions is a factor that increases the risk of instrumentalization.
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- 2024
12. Identifying high school risk factors that forecast heavy drinking onset in understudied young adults
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Zhao, Qingyu, Zhao, Qingyu, Paschali, Magdalini, Dehoney, Joseph, Baker, Fiona C, de Zambotti, Massimiliano, De Bellis, Michael D, Goldston, David B, Nooner, Kate B, Clark, Duncan B, Luna, Beatriz, Nagel, Bonnie J, Brown, Sandra A, Tapert, Susan F, Eberson, Sonja, Thompson, Wesley K, Pfefferbaum, Adolf, Sullivan, Edith V, Pohl, Kilian M, Zhao, Qingyu, Zhao, Qingyu, Paschali, Magdalini, Dehoney, Joseph, Baker, Fiona C, de Zambotti, Massimiliano, De Bellis, Michael D, Goldston, David B, Nooner, Kate B, Clark, Duncan B, Luna, Beatriz, Nagel, Bonnie J, Brown, Sandra A, Tapert, Susan F, Eberson, Sonja, Thompson, Wesley K, Pfefferbaum, Adolf, Sullivan, Edith V, and Pohl, Kilian M
- Abstract
Heavy alcohol drinking is a major, preventable problem that adversely impacts the physical and mental health of US young adults. Studies seeking drinking risk factors typically focus on young adults who enrolled in 4-year residential college programs (4YCP) even though most high school graduates join the workforce, military, or community colleges. We examined 106 of these understudied young adults (USYA) and 453 4YCPs from the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) by longitudinally following their drinking patterns for 8 years from adolescence to young adulthood. All participants were no-to-low drinkers during high school. Whereas 4YCP individuals were more likely to initiate heavy drinking during college years, USYA participants did so later. Using mental health metrics recorded during high school, machine learning forecasted individual-level risk for initiating heavy drinking after leaving high school. The risk factors differed between demographically matched USYA and 4YCP individuals and between sexes. Predictors for USYA drinkers were sexual abuse, physical abuse for girls, and extraversion for boys, whereas 4YCP drinkers were predicted by the ability to recognize facial emotion and, for boys, greater openness. Thus, alcohol prevention programs need to give special consideration to those joining the workforce, military, or community colleges, who make up the majority of this age group.
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- 2024
13. Epidermal growth factor augments the self-renewal capacity of aged hematopoietic stem cells.
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Chang, Vivian, Chang, Vivian, He, Yuwei, Grohe, Samantha, Brady, Morgan, Chan, Aldi, Kadam, Rucha, Fang, Tiancheng, Pang, Amara, Pohl, Katherine, Tran, Evelyn, Li, Michelle, Kan, Jenny, Zhang, Yurun, Lu, Josie, Sasine, Joshua, Himburg, Heather, Yue, Peibin, Chute, John, Chang, Vivian, Chang, Vivian, He, Yuwei, Grohe, Samantha, Brady, Morgan, Chan, Aldi, Kadam, Rucha, Fang, Tiancheng, Pang, Amara, Pohl, Katherine, Tran, Evelyn, Li, Michelle, Kan, Jenny, Zhang, Yurun, Lu, Josie, Sasine, Joshua, Himburg, Heather, Yue, Peibin, and Chute, John
- Abstract
Hematopoietic aging is associated with decreased hematopoietic stem cell (HSC) self-renewal capacity and myeloid skewing. We report that culture of bone marrow (BM) HSCs from aged mice with epidermal growth factor (EGF) suppressed myeloid skewing, increased multipotent colony formation, and increased HSC repopulation in primary and secondary transplantation assays. Mice transplanted with aged, EGF-treated HSCs displayed increased donor cell engraftment within BM HSCs and systemic administration of EGF to aged mice increased HSC self-renewal capacity in primary and secondary transplantation assays. Expression of a dominant negative EGFR in Scl/Tal1+ hematopoietic cells caused increased myeloid skewing and depletion of long term-HSCs in 15-month-old mice. EGF treatment decreased DNA damage in aged HSCs and shifted the transcriptome of aged HSCs from genes regulating cell death to genes involved in HSC self-renewal and DNA repair but had no effect on HSC senescence. These data suggest that EGFR signaling regulates the repopulating capacity of aged HSCs.
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- 2024
14. Superfluid-supersolid phase transition of elongated dipolar Bose-Einstein condensates at finite temperatures
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Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. CCQM - Condensed, Complex and Quantum Matter Group, Sánchez Baena, Juan, Pohl, Thomas, Maucher, Fabian, Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. CCQM - Condensed, Complex and Quantum Matter Group, Sánchez Baena, Juan, Pohl, Thomas, and Maucher, Fabian
- Abstract
We analyze the finite-temperature phase diagram of a dipolar Bose-Einstein condensate confined in a tubular geometry. The effect of thermal fluctuations is accounted for by means of Bogoliubov theory employing the local density approximation. In the considered geometry, the superfluid-supersolid phase transition can be of first and second order. We discuss how the corresponding transition point is affected by the finite temperature of the system., Postprint (published version)
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- 2024
15. Der Charlson-Deyo Komorbiditätsindex als neuer Tumorrezidiv-Prediktor bei nicht-muskelinvasivem Blasenkarzinom
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Scheipner, L, Zurl, H, Altziebler, JV, Pichler, G, Schöpfer, S, Jasarevic, S, Pohl, K, Pemberger, K, Hutterer, G, Bele, U, Leitsmannn, C, Leitsmann, M, Augustin, H, Zigeuner, R, Ahyai, S, Mischinger, J, Scheipner, L, Zurl, H, Altziebler, JV, Pichler, G, Schöpfer, S, Jasarevic, S, Pohl, K, Pemberger, K, Hutterer, G, Bele, U, Leitsmannn, C, Leitsmann, M, Augustin, H, Zigeuner, R, Ahyai, S, and Mischinger, J
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- 2024
16. Kognitive transperineale Mikro-Ultraschall/Magnetresonanztomographie fusionierte Prostatabiopsie - ist die additive systematische Biopsie noch zeitgemäß?
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Mischinger, J, Katzmann, M, Simunovic, I, Bele, U, Leitsmann, C, Leitsmann, M, Jasarevic, S, Schöpfer-Schwab, S, Scheipner, L, Zurl, H, Pohl, K, Altziebler, J, Ahyai, S, Mannweiler, S, Talakic, E, Augustin, H, Zigeuner, R, Hutterer, GC, Mischinger, J, Katzmann, M, Simunovic, I, Bele, U, Leitsmann, C, Leitsmann, M, Jasarevic, S, Schöpfer-Schwab, S, Scheipner, L, Zurl, H, Pohl, K, Altziebler, J, Ahyai, S, Mannweiler, S, Talakic, E, Augustin, H, Zigeuner, R, and Hutterer, GC
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- 2024
17. Implementierung von ePROMs nach offener und roboterassistierter radikaler Prostatektomie beim lokalisierten Prostatakarzinom - erste Erfahrungen und Ergebnisse einer prospektiven, monozentrischen Beobachtungsstudie
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Zurl, H, Mischinger, J, Riedl, JM, Scheipner, L, Pohl, KK, Leitsmann, C, Augustin, H, Zigeuner, R, Avian, A, Sendlhofer, G, Ahyai, S, Leitsmann, M, Zurl, H, Mischinger, J, Riedl, JM, Scheipner, L, Pohl, KK, Leitsmann, C, Augustin, H, Zigeuner, R, Avian, A, Sendlhofer, G, Ahyai, S, and Leitsmann, M
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- 2024
18. Risiko für Harnwegsinfektionen und Beurteilung der Lebensqualität bei Patient*innen mit intermittierendem Selbstkatheterismus
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Jankovic, D, Jooma, N, Jasarevic, S, Mangge, A, Pemberger, K, Pohl, K, Leitsmann, C, Ahyai, S, Leitsmann, M, Jankovic, D, Jooma, N, Jasarevic, S, Mangge, A, Pemberger, K, Pohl, K, Leitsmann, C, Ahyai, S, and Leitsmann, M
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- 2024
19. Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs
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van Bergen, Wouter, Zuna, Kristina, Fiala, Jan, Pohl, Elena E., Heck, Albert J. R., Baggelaar, Marc P., van Bergen, Wouter, Zuna, Kristina, Fiala, Jan, Pohl, Elena E., Heck, Albert J. R., and Baggelaar, Marc P.
- Abstract
Comparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-target interactions, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino acid side chains and these drugs. Thus, studying drug-protein interactions at an amino acid resolution provides a comprehensive understanding of the drug selectivity and efficacy. In this study, we further refined the site-specific activity-based protein profiling strategy (ABPP), PhosID-ABPP, on a timsTOF HT mass spectrometer. This refinement enables dual dose-dependent competition of inhibitors within a single cellular proteome. Here, a comparative analysis of two activity-based probes (ABPs), developed to selectively target the epidermal growth factor receptor (EGFR), namely, PF-06672131 (PF131) and PF-6422899 (PF899), facilitated the simultaneous identification of ABP-specific binding sites at a proteome-wide scale within a cellular proteome. Dose-dependent probe-binding preferences for proteinaceous cysteines, even at low nanomolar ABP concentrations, could be revealed. Notably, in addition to the intrinsic affinity of the electrophilic probes for specific sites in targeted proteins, the observed labeling intensity is influenced by several other factors. These include the efficiency of cellular uptake, the stability of the probes, and their intracellular distribution. While both ABPs showed comparable labeling efficiency for EGFR, PF131 had a broader off-target reactivity profile. In contrast, PF899 exhibited a higher labeling efficiency for the ERBB2 receptor and bound to catalytic cysteines in several other enzymes, which is likely to disrupt their catalytic activity. Notably, PF131 effectively labeled ADP/ATP translocase proteins at a concentration of just 1 nm, and we found this affected ATP transport. Analysis of the effect of PF131 and its parent
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- 2024
20. Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia
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Mulet-Lazaro, Roger, van Herk, Stanley, Nuetzel, Margit, Sijs-Szabo, Aniko, Díaz, Noelia, Kelly, Katherine, Erpelinck-Verschueren, Claudia, Schwarzfischer-Pfeilschifter, Lucia, Stanewsky, Hanna, Ackermann, Ute, Glatz, Dagmar, Raithel, Johanna, Fischer, Alexander, Pohl, Sandra, Rijneveld, Anita, Vaquerizas, Juan M., Thiede, Christian, Plass, Christoph, Wouters, Bas J., Delwel, Ruud, Rehli, Michael, Gebhard, Claudia, Mulet-Lazaro, Roger, van Herk, Stanley, Nuetzel, Margit, Sijs-Szabo, Aniko, Díaz, Noelia, Kelly, Katherine, Erpelinck-Verschueren, Claudia, Schwarzfischer-Pfeilschifter, Lucia, Stanewsky, Hanna, Ackermann, Ute, Glatz, Dagmar, Raithel, Johanna, Fischer, Alexander, Pohl, Sandra, Rijneveld, Anita, Vaquerizas, Juan M., Thiede, Christian, Plass, Christoph, Wouters, Bas J., Delwel, Ruud, Rehli, Michael, and Gebhard, Claudia
- Abstract
Leukemias with ambiguous lineage comprise several loosely defined entities, often without a clear mechanistic basis. Here, we extensively profile the epigenome and transcriptome of a subgroup of such leukemias with CpG Island Methylator Phenotype. These leukemias exhibit comparable hybrid myeloid/lymphoid epigenetic landscapes, yet heterogeneous genetic alterations, suggesting they are defined by their shared epigenetic profile rather than common genetic lesions. Gene expression enrichment reveals similarity with early T-cell precursor acute lymphoblastic leukemia and a lymphoid progenitor cell of origin. In line with this, integration of differential DNA methylation and gene expression shows widespread silencing of myeloid transcription factors. Moreover, binding sites for hematopoietic transcription factors, including CEBPA, SPI1 and LEF1, are uniquely inaccessible in these leukemias. Hypermethylation also results in loss of CTCF binding, accompanied by changes in chromatin interactions involving key transcription factors. In conclusion, epigenetic dysregulation, and not genetic lesions, explains the mixed phenotype of this group of leukemias with ambiguous lineage. The data collected here constitute a useful and comprehensive epigenomic reference for subsequent studies of acute myeloid leukemias, T-cell acute lymphoblastic leukemias and mixed-phenotype leukemias.
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- 2024
21. The role of affective commitment in the workers’ wellbeing: A comparison between workers from private and public sectors
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BAPS Annual Meeting (30/05/2024-31/05/2024: VUB), Pudles, Nathan, Willeput, Marine, Pohl, Sabine, Verdonck, Magali, Decroly, Jean-Michel, Duchene, Claire, Strale, Mathieu, Hellemans, Catherine, BAPS Annual Meeting (30/05/2024-31/05/2024: VUB), Pudles, Nathan, Willeput, Marine, Pohl, Sabine, Verdonck, Magali, Decroly, Jean-Michel, Duchene, Claire, Strale, Mathieu, and Hellemans, Catherine
- Abstract
info:eu-repo/semantics/published
- Published
- 2024
22. Towards unified drought analysis: Detecting direct and legacy effects on forest carbon cycling in eddy covariance data
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Pohl, Felix and Pohl, Felix
- Abstract
Carbon and water fluxes in terrestrial ecosystems are intrinsically coupled across a range of spatial and temporal scales. Water scarcity therefore directly affects the carbon uptake of ecosystems, and the increasing frequency and magnitude of droughts can lead to severe perturbations in the carbon cy-cle, potentially accelerating the pace of global climate change. Forests, in particular, play an important role in the terrestrial carbon cycle, but the long-term effects of extreme events are poorly understood, making it difficult to accurately project the future trajectory of the carbon cycle. In summary, this work highlights several challenges when analysing observational eddy covariance data regarding drought effects. The importance of accurate upscaling of soil moisture measurements and standardised definitions of drought events must be considered in order to derive meaningful results. Recent advances in interpretable machine learning and the increasing availability of eddy covariance measurements across different biomes and multiple decades now allow the non-linear relationships to be investigated in large-scale studies. Further research must take into account the temporal and spatial autocorrelation of the data, the reliability of the available data and standardised definitions of extreme events.
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- 2024
23. Multicentric Outlier Detection Algorithm for Healthcare Laboratory Data
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Belov, V, von Münchow-Pohl, C, Kittner, M, Löser, S, Martens, P, Ortleb, S, Bockhacker, M, Belov, V, von Münchow-Pohl, C, Kittner, M, Löser, S, Martens, P, Ortleb, S, and Bockhacker, M
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- 2024
24. Integration und Standardisierung von Verschreibungsdaten aus heterogenen Medikationssystemen
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von Münchow-Pohl, C, Löser, S, Belov, V, Martens, P, Ortleb, S, Bockhacker, M, von Münchow-Pohl, C, Löser, S, Belov, V, Martens, P, Ortleb, S, and Bockhacker, M
- Published
- 2024
25. COVID-19 und Einsamkeit: Ausmaß und Analyse der wahrgenommenen Einsamkeit im Zusammenhang mit soziodemografischen Merkmalen und der seelischen und emotionalen Gesundheit einer Blutspender-Kohorte (SeMaCo)
- Author
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Pohl, R, Stallmann, C, Scheibler, L, Marquardt, P, Bank, U, Kaasch, AJ, Heuft, HG, Apfelbacher, C, Pohl, R, Stallmann, C, Scheibler, L, Marquardt, P, Bank, U, Kaasch, AJ, Heuft, HG, and Apfelbacher, C
- Published
- 2024
26. Controlled formation of surface films of size selected clusters grown in helium nanodroplets
- Author
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Pohl, Thomas and Pohl, Thomas
- Abstract
This thesis presents a novel experimental setup that generates a high intensity beam of helium nanodroplets (HNDs) by supersonic jet expansion. After multiply charging the droplets via electron impact ionization (EI), it is possible to dope the HNDs with almost any sample of choice by vapor pickup. In the future, the machine shall be utilized to create custom made, size selected nanoparticles (NPs) by adjusting the experimental conditions accordingly, thereby facilitating the production of tailor made surface films via deposition onto a substrate. In this study, we present fundamental source charac- terization measurements, as well as preliminary deposition of bismuth onto silicate glass samples. The dependence of the size-per-charge distribution on electron current and electron energy are showcased. Results indicate upper ionization limits for both pa- rameters, while simultaneously implying the existence of highly charged droplets, which are a prerequisite for the formation of uniformly sized clusters. Initial surface deposi- tion tests demonstrate a clear qualitative difference of HND mediated dopant deposition versus vapor deposition., Masterarbeit Universität Innsbruck 2024
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- 2024
27. Acting as we feel : Which emotional responses to the climate crisis motivate climate action
- Author
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Kovacs, Lilla Nora, Jordan, Gesine, Berglund, Frida, Holden, Benedict, Niehoff, Elena, Pohl, Felicia, Younssi, Mariem, Zevallos, Ines, Agoston, Csilla, Vargai, Attila, Kokonyei, Gyongyi, Kovacs, Lilla Nora, Jordan, Gesine, Berglund, Frida, Holden, Benedict, Niehoff, Elena, Pohl, Felicia, Younssi, Mariem, Zevallos, Ines, Agoston, Csilla, Vargai, Attila, and Kokonyei, Gyongyi
- Abstract
The current study assessed emotional responses and emotion regulation strategies to the climate crisis, and their relationship to pro-environmental behaviour cross-sectionally using self-report online surveys. 1307 participants were recruited through convenience sampling from six European countries, alongside a distinct sample of 1040 participants representative of age, sex, and ethnicity in the United States. Our findings replicated the well-known association that stronger negative emotions to the climate crisis are associated with more pro-environmental behaviour. The relationship between climate emotions and pro-environmental behaviour was moderated by resignation in the US sample, by cognitive reappraisal and other-blame in the European sample and mediated by rumination in both samples. Furthermore, latent profiles of emotional responses were identified. In both samples, there was one distinct class demonstrating strong climate emotions, and a group with very low or no climate emotions (alongside with two/three groups with moderate emotional intensity in the European and the US samples, respectively). Findings also revealed that members of the emotional group were more likely to take climate action and tend to engage more in emotion regulation than the unemotional group. Our results highlight the crucial role of emotions and emotion regulation strategies in mitigating the climate crisis by taking pro- environmental action.
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- 2024
- Full Text
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28. Chemical interdiffusion between Na-series tephritic and phonolitic melts with different H2O content, temperature, and oxygen fugacity values
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González García, Diego, Pohl, Florian, Marxer, Felix, Krasheninnikov, Stepan, Almeev, Renat, Holtz, François, González García, Diego, Pohl, Florian, Marxer, Felix, Krasheninnikov, Stepan, Almeev, Renat, and Holtz, François
- Abstract
The diffusive exchange of major elements in Na-series tephrite–phonolite diffusion couples with compositions relevant to the Canary Islands magmatism was determined at 300 MPa and variable H2O concentrations (0.3 wt % to 3.3 wt %), temperatures (1150 to 1300 °C), and fO2 levels (NNO−1.5 to NNO+1.7). Composition-dependent effective binary diffusion coefficients were determined from concentration–distance profiles. Results show a wide range of diffusivities for different cations, consistently following the sequence Na ≫ Al ≫ K ≥ Mg = Fe = Ca > Si > Ti, with a mild diffusivity contrast (0.2–0.8 log units) between tephritic and phonolitic melts. Na is the fastest component, with diffusivities falling ∼1.0 log units above those of Si for any given condition. An anomalously fast Al diffusion is observed, with DAl falling ∼0.4 log units above Si and ∼0.6 log units below Na, suggesting a prevalence of Al–alkali coupling across our range of run conditions. The relationships between log D and H2O content in melt for all cations in an intermediate composition are strongly nonlinear and can be fitted using an exponential function with a convergence in diffusion coefficients for different temperatures with increasing H2O content. Thus, Arrhenius analyses result in a decrease in activation energies from 222–293 kJ mol−1 at 1.7 wt % H2O to 48–112 kJ mol−1 at 3.0 wt % H2O. These results provide new data on chemical interdiffusion in highly alkaline Na-rich melts and suggest that H2O content plays a key role in increasing the chemical efficiency of magma mixing at low temperatures. The obtained dataset is used to test chemical controls of magma mixing in the El Abrigo ignimbrite, Tenerife, where banded pumices involving basanitic–tephritic to phonolitic magmas are common in several compositionally bimodal ignimbrite units., Alexander von Humboldt Stiftung, Deutsche Forschungsgemeinschaft, Depto. de Mineralogía y Petrología, Fac. de Ciencias Geológicas, TRUE, pub
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- 2024
29. Inward Foreign Investment Screening in Australia: Development and Implications
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Pohl, JH, Warchol, J, Papadopoulos, T, Wiesenthal, J, Walter, A, McCalman, P, Puzzello, L, Voon, T, Pohl, JH, Warchol, J, Papadopoulos, T, Wiesenthal, J, Walter, A, McCalman, P, Puzzello, L, and Voon, T
- Abstract
This chapter outlines political, legal and economic aspects of Australia’s inward foreign investment screening regime, taking account of the historical development of the legislative framework and its practical implementation to date. Australian screening is characterised by high levels of discretion in the Treasurer, within broad policy parameters regarding the meaning of ‘national interest’ and ‘national security’. The impact of the most recent changes as of 2021 is difficult to assess, but they have clearly increased the number of investment proposals that are subject to review. Although most applications are approved, approval with conditions is common, while other applications may be withdrawn following informal feedback, obviating the need for formal rejection. The increasing restrictiveness of Australia’s approach and its continuing differentiation between investors from different countries create risks of violating one of Australia’s 30+ international investment agreements in force, the majority of which include investor–state dispute settlement mechanisms. The economic and diplomatic rationale for such restrictiveness and differentiation (particularly in the form of higher screening thresholds for some but not all of Australia’s preferential trade agreement partners) is unclear.
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- 2024
30. Förändring av hållbarhetspoäng : Effekter på aktiepris bland företag som är noterade i Sverige
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Pohl, Leonard, Söderquist, Albert, Pohl, Leonard, and Söderquist, Albert
- Abstract
Denna studie undersöker effekten av hållbarhetsprestation på aktiepris. Detta görs genom att mäta förändringar av ESG poäng, miljöpoäng, social poäng och styrningspoäng mellan räkenskapsåren 2021-2022 och undersöker effekten på aktiepris genom eventstudiemetod. Eventdagen definieras som justerat publiceringsdatum för företagens års- och hållbarhetsredovisning för räkenskapsåret 2022. Urvalet utgörs av 305 företag som är noterade på svenska aktiemarknader och hämtas från databasen Refinitiv Eikon. Observationerna delas in i positiv samt negativ relativ förändring beroende på om de ligger över eller under medianen i förändring av hållbarhetspoäng. Studien finner inga signifikanta förändringar (p > 0,1) i aktiepriser till följd av förändringar i ESG poäng, miljöpoäng, social poäng eller styrningspoäng. Studien begränsas av tidsperioden, urvalsstorleken samt att hållbarhetspoängen enbart är utfärdad av LSEG. Studien kompletterar befintlig forskning genom att fokusera på företag noterade i Sverige samt genom att studera effekten av förändring av hållbarhetspoäng., This study examines the effect of sustainability performance on stock prices by measuring changes in ESG scores, environmental scores, social scores, and governance scores between the fiscal years 2021-2022. Event study methodology is used with the event day defined as the adjusted publication date of annual and sustainability reports for the fiscal year 2022. The sample consists of 305 companies listed on Swedish stock markets sourced from Refinitiv Eikon. Observations are categorized into positive/negative relative change based on whether they exceed/fall below the median. The study finds no significant changes (p > 0,1) in stock prices as a result of changes in ESG scores, environmental scores, social scores, or governance scores. Limitations exist in the time period, sample size and using only sustainability scores issued by LSEG. Contributions to existing research comes from focusing on Sweden and the method being used.
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- 2024
31. An Interplay Between Barriers & Enablers : Swedish Multinational SMEs Journey Towards Implementing the Sustainable Development Goals
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Yunusbayeva, Gyulnara, Hjelmberg, Jens, Pohl, Hanna, Yunusbayeva, Gyulnara, Hjelmberg, Jens, and Pohl, Hanna
- Abstract
Sustainability is a topic that gains more attention each year and new legislationforces companies around the world to follow more strict reporting. At the sametime, the United Nations (UN) has updated its Millennium Development Goals(MDGs) to the newer Sustainable Development Goals (SDGs) that aresupposed to be marked throughout corporations, governments, and nations.These new goals are important for both emerging countries as well asdeveloped countries to strive for a better world for all. This thesis aimed toinvestigate what barriers and enablers Multinational Small and Medium-sizedEnterprises (MSMEs) in Sweden met when they incorporated the UN SDGsinto their companies' operations. The research aimed to find how the MSMEsdealt with various barriers, what enablers support SDGs implementation, andthe best practices for other (M)SMEs to follow. A qualitative multi-case studywith different MSMEs in Sweden was chosen through an abductive approachand thematic analysis. Furthermore, the SDGs4SMEs Roadmap to SDGsimplementation in (M)SMEs was created by the authors as a contribution toacademic international business studies as well for Swedish (M)SMEs. In theempirical findings chapter, several barriers and enablers were discovered, andhow MSMEs dealt with them. In the conclusion part, theoretical implicationsare given. Moreover, by comparing the empirical data retrieved, theresearchers identified best practices for (M)SMEs that further facilitate SDGsimplementation. As a result, recommendations for policymakers and managersare conveyed in a step-by-step manner to be easily applicable for most(M)SMEs around Sweden. This is the authors’ contribution, the SDGs4SMEsRoadmap followed by limitations and future research recommendations.
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- 2024
32. Das Heim als (un-)sicherer Ort – Perspektiven von Kindern auf das Leben in der stationären Kinder- und Jugendhilfe
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Pohl, Carina and Pohl, Carina
- Abstract
Wenn Kinder in Fremdunterbringung sind, erfahren sie einen Mangel an Sicherheit und Geborgenheit in vielfältigen Facetten. Oftmals fehlt es an Informationen über zentrale Abläufe und die Gründe ihrer Platzierung. Die physische Trennung von den Eltern führt dazu, dass sie fortan an einem unbekannten Ort, dem Heim, leben. Trotz der Überzeugung vieler Fachleute, dass ein Heim als sicherer Ort dient, um die Unsicherheit in der Familie zu kompensieren, zeigen frühere Studien ein erhöhtes Gewaltrisiko für Kinder in solchen Einrichtungen. Dies wirft die Frage auf, ob vermeintlich sichere Orte in verschiedener Hinsicht tatsächlich unsicher werden können. Um zu ergründen, was Kindern bezüglich Sicherheit wichtig ist und wie sie Sicherheit in Heimsituationen konkret erleben, wurde in der Schweiz eine qualitative Studie mit Kindern im Alter von 8 bis 14 Jahren durchgeführt.
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- 2024
33. Generation «No Future»? Sicherheit vermitteln in einer fragilen Welt : Abschlusskommentar
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Pohl, Carina and Pohl, Carina
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- 2024
34. Exploring the Relationship Between the Explicitness of Emotional Display Rules and Well-Being among Nurses: The Mediating Influence of Rules’ Internalization
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Pohl, Sabine, librecht, julien, Doudy-Michez, Orchidée, Dal Santo, Letizia, Pohl, Sabine, librecht, julien, Doudy-Michez, Orchidée, and Dal Santo, Letizia
- Abstract
info:eu-repo/semantics/published
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- 2024
35. Data publication: Tunable Crystallinity and Electron Conduction in Wavy 2D Conjugated Metal-Organic Frameworks via Halogen Substitution
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Jastrzembski, K., Zhang, Y., Lu, Y., Sporrer, L., Pohl, D., Rellinghaus, B., Waentig, A. L., Zhang, H., Mücke, D., Fu, S., Polozij, M., Li, X., Zhang, J., Wang, M., Morag, A., Yu, M., Mateo-Alonso, A., Wang, H. I., Bonn, M., Kaiser, U., (0000-0003-2379-6251) Heine, T., Dong, R., Feng, X., Jastrzembski, K., Zhang, Y., Lu, Y., Sporrer, L., Pohl, D., Rellinghaus, B., Waentig, A. L., Zhang, H., Mücke, D., Fu, S., Polozij, M., Li, X., Zhang, J., Wang, M., Morag, A., Yu, M., Mateo-Alonso, A., Wang, H. I., Bonn, M., Kaiser, U., (0000-0003-2379-6251) Heine, T., Dong, R., and Feng, X.
- Abstract
SinglePoint + band structure calculations for Cu3(HF-HH-cHBC)2 material using VASP software.
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- 2024
36. Sicherheit und Unsicherheit aus der Perspektive von Kindern in der Kinder- und Jugendhilfe
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Pohl, Carina and Pohl, Carina
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- 2024
37. Digitalisierung historischer Bestände : Daten, Praktiken und Institutionen
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Dreesen, Philipp, Pohl, Peter, Dreesen, Philipp, and Pohl, Peter
- Abstract
Der Vortrag nimmt eine Metaperspektive auf die Diskussionen zu analogen und digitalen Wissenszugängen ein. Konkret werden anhand eines Beispiels und mit Bezug auf die ORD-Transformation Veränderungen im Zugang zu Wissensbeständen aufgezeigt und diskutiert. Hierbei wird auf Praktiken der Datenerschliessung, den Wandel der Datennutzung, den Data Life Cycle, mögliche Praktiken der Verschränkung sowie eine (Quellen-)Kritik des Digitalen eingegangen.
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- 2024
38. Die Einweisung des psychiatrischen Patienten nach der Unterbringungsgesetz-Novelle 2023
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Mair-Pohl, Lisa Anna and Mair-Pohl, Lisa Anna
- Abstract
Mit Juni 2023 trat in Österreich die bisher umfassendste Novelle des Unterbringungs- gesetzes (UbG) in Kraft. Das Gesetz wurde umfassend reformiert und zeigt sich sowohl inhaltlich als auch formell aufgewertet. Nachdem eine Sonderkommission der Regie- rung nach einem tragischen Vorfall, in dem ein psychisch kranker Mann eine Frau er- mordet hatte, in ihren Untersuchungen Mängel in der Kommunikation zwischen Behör- den und unterschiedlichen Beteiligten festgestellt hatte, war ein starker Fokus der Ge- setzesreformierung die bessere Vernetzung untereinander. Weitere, in einer wissen- schaftlichen Forschungsarbeit ermittelte, Schwachstellen des UbG waren fehlende Son- derregelungen für Minderjährige, uneindeutige Zuständigkeiten der aufnehmenden Be- rufsgruppen sowie Inkonsistenzen mit der UN- Behindertenrechtskonvention (UN-BRK). Alle diese Punkte wurden umfassend ermittelt und diskutiert und fanden Eingang in das reformierte Gesetz. Die vorliegende Arbeit soll alle relevanten Neuerungen für die Situation der Einweisung und Unterbringung erfassen, ausführlich darstellen und mit besonderem Fokus auf grundrechtliche Anliegen diskutieren., With June 2023 a new version of the accommodation law in Austria came into force. The law was reformed extensively and shows up with innovations in terms of content as well as in terms of structure. After a tragic event, where a woman has been murdered by a mentally ill man, a special commission of the government has been reappraising the si- tuation and was detecting shortages in the legal basis as well as in the execution of all involved departments. There were found outstanding deficiencies in communication between specialists, police and other involved departments. Therefore the reformation was strongly focussed on optimizing networking and sharing important information between all involved task forces. Further, scientific research showed the need for improvement concerning the legal basis for minors, in fulfilling the guidelines of the Convention on the Rights of Persons with Disabilities (CRPD) and regarding legal clarity in terms of individual competences. All these topics has been excessively discussed and examined and are forming the basis for the new accommodation law. The following thesis intends to carve out all novelties con- cerning the admittance and compulsory hospitalization of psychiatric patients and fur- thermore examining and discussing them from a fundamental rights point of view., Verfasserin: Dr. med. univ. Lisa Anna Mair-Pohl, in englischer Sprache, Masterarbeit Universität Innsbruck, Universitätslehrgang Medizinrecht 2024
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- 2024
39. On the plerionic rectangular supernova remnants of static progenitors
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Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, European Commission, Universidad Nacional Autónoma de México, Meyer, Dominique M.-A., Meliani, Zakaria, Velázquez, Pablo F., Pohl, M., Torres, Diego F., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia e Innovación (España), Generalitat de Catalunya, European Commission, Universidad Nacional Autónoma de México, Meyer, Dominique M.-A., Meliani, Zakaria, Velázquez, Pablo F., Pohl, M., and Torres, Diego F.
- Abstract
Pulsar wind nebulae are a possible final stage of the circumstellar evolution of massive stars, where a fast-rotating, magnetized neutron star produces a powerful wind that interacts with the supernova ejecta. The shape of these so-called plerionic supernova remnants is influenced by the distribution of circumstellar matter at the time of the explosion, itself impacted by the magnetic field of the ambient medium, responsible for the expansion of the circumstellar bubble of the progenitor star. To understand the effects of magnetization on the circumstellar medium and resulting pulsar nebulae, we conduct 2D magnetohydrodynamic simulations. Our models explore the impact of the interstellar medium’s (ISM) magnetic field on the morphology of a supernova remnant and pulsar wind nebula that develop in the circumstellar medium of massive star progenitor in the warm phase of the Milky Way’s ISM. Our simulations reveal that the jet-like structures formed on both sides perpendicularly to the equatorial plane of the pulsar, creating complex radio synthetic synchrotron emissions. This morphology is characterized by a rectangular-like remnant, which is typical of the circumstellar medium of massive stars in a magnetized medium, along with the appearance of a spinning top structure within the projected rectangle. We suggest that this mechanism may be partially responsible for the complex morphologies observed in pulsar wind nebulae that do not conform to the typical torus/jet or bow shock/tail shapes observed in most cases.
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- 2024
40. Supernova remnants of red supergiants: from barrels to Cygnus loops
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Meyer, D M A, Velazquez, P F, Pohl, M, Egberts, K, Petrov, M, Villagran, M A, Torres, D F, Batzofin, R, Meyer, D M A, Velazquez, P F, Pohl, M, Egberts, K, Petrov, M, Villagran, M A, Torres, D F, and Batzofin, R
- Abstract
Core-collapse supernova remnants are the nebular leftover of defunct massive stars which have died during a supernova explosion, mostly while undergoing the red supergiant phase of their evolution. The morphology and emission properties of those remnants are a function of the distribution of circumstellar material at the moment of the supernova, the intrisic properties of the explosion, as well as those of the ambient medium. By means of 2.5 dimensional numerical magnetohydrodynamics simulations, we model the long term evolution of supernova remnants generated by runaway rotating massive stars moving into a magnetised interstellar medium. Radiative transfer calculations reveal that the projected non-thermal emission of the supernova remnants decreases with time, i.e. older remnants are fainter than younger ones. Older (80 kyr) supernova remnants whose progenitors were moving with space velocity corresponding to a Mach number M = 1 (v_star = 20 km/s ) in the Galactic plane of the ISM (nISM = 1/cm3 ) are brighter in synchrotron than when moving with a Mach number M = 2 (v_star = 40 km/s ). We show that runaway red supergiant progenitors first induce an asymmetric non thermal 1.4 GHz barrel like synchrotron supernova remnants (at the age of about 8 kyr), before further evolving to adopt a Cygnus loop like shape (at about 80 kyr). It is conjectured that a significative fraction of supernova remnants are currently in this bilateral-to-Cygnus-loop evolutionary sequence, and that this should be taken into account in the data interpretation of the forthcoming Cherenkov Telescope Array (CTA) observatory., Comment: Accepted at Astronomie and Astrophysics
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- 2024
41. Dark Matter Line Searches with the Cherenkov Telescope Array
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Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. Rosales, Rowell, G., Rudak, B., Ruiter, A. J., Rulten, C. B., Sadeh, I., Saha, L., Saito, T., Salzmann, H., Sánchez-Conde, M., Sandaker, H., Sangiorgi, P., Sano, H., Santander, M., Santos-Lima, R., Sapienza, V., Šarić, T., Sarkar, A., Sarkar, S., Saturni, F. G., Savarese, S., Scherer, A., Schiavone, F., Schipani, P., Schleicher, B., Schovanek, P., Schubert, J. L., Schwanke, U., Arroyo, M. Seglar, Seitenzahl, I. R., Sergijenko, O., Servillat, M., Siegert, T., Siejkowski, H., Siqueira, C., Sliusar, V., Slowikowska, A., Sol, H., Spencer, S. T., Spiga, D., Stamerra, A., Stanič, S., Starecki, T., Starling, R., Stawarz, Ł., Steppa, C., Hatlen, E. Sæther, Stolarczyk, T., Strišković, J., Suda, Y., Świerk, P., Tajima, H., Tak, D., Takahashi, M., Takeishi, R., Tavernier, T., Tejedor, L. A., Terauchi, K., Teshima, M., Testa, V., Tian, W. W., Tibaldo, L., Tibolla, O., Peixoto, C. J. Todero, Torradeflot, F., Torres, D. F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., Zuriaga-Puig, J., Abe, S., Abhir, J., Abhishek, A., Acero, F., Acharyya, A., Adam, R., Aguasca-Cabot, A., Agudo, I., Aguirre-Santaella, A., Alfaro, J., Alfaro, R., Alvarez-Crespo, N., Batista, R. Alves, Amans, J. -P., Amato, E., Ambrosi, G., Angel, L., Aramo, C., Arcaro, C., Arnesen, T. T. H., Arrabito, L., Asano, K., Ascasibar, Y., Aschersleben, J., Ashkar, H., Backes, M., Baktash, A., Balazs, C., Balbo, M., Larriva, A. Baquero, Martins, V. Barbosa, de Almeida, U. Barres, Barrio, J. A., Batković, I., Batzofin, R., Baxter, J., González, J. Becerra, Beck, G., Benbow, W., Berge, D., Bernardini, E., Bernete, J., Bernlöhr, K., Berti, A., Bertucci, B., Bhattacharjee, P., Bhattacharyya, S., Bigongiari, C., Biland, A., Bissaldi, E., Biteau, J., Blanch, O., Blazek, J., Bocchino, F., Boisson, C., Bolmont, J., Bonnoli, G., Bonollo, A., Bordas, P., Bosnjak, Z., Bottacini, E., Böttcher, M., Bringmann, T., Bronzini, E., Brose, R., Brown, A. M., Brunelli, G., Bulgarelli, A., Bulik, T., Burelli, I., Burmistrov, L., Burton, M., Buscemi, M., Bylund, T., Cailleux, J., Campoy-Ordaz, A., Cantlay, B. K., Capasso, G., Caproni, A., Capuzzo-Dolcetta, R., Caraveo, P., Caroff, S., Carosi, A., Carosi, R., Carquin, E., Carrasco, M. -S., Cassol, F., Castaldini, L., Castrejon, N., Castro-Tirado, A. J., Cerasole, D., Cerruti, M., Chadwick, P. M., Chaty, S., Chen, A. W., Chernyakova, M., Chiavassa, A., Chudoba, J., Chytka, L., Cicciari, G. M., Cifuentes, A., Araujo, C. H. Coimbra, Colapietro, M., Conforti, V., Conte, F., Contreras, J. L., Costa, A., Costantini, H., Cotter, G., Cristofari, P., Cuevas, O., Curtis-Ginsberg, Z., D'Amico, G., D'Ammando, F., Dai, S., Dalchenko, M., Dazzi, F., De Angelis, A., de Lavergne, M. de Bony, De Caprio, V., Pino, E. M. de Gouveia Dal, De Lotto, B., De Lucia, M., de Menezes, R., de Naurois, M., de Souza, V., del Peral, L., del Valle, M. V., Giler, A. G. Delgado, Mengual, J. Delgado, Delgado, C., Dell'aiera, M., della Volpe, D., Depaoli, D., Di Girolamo, T., Di Piano, A., Di Pierro, F., Di Tria, R., Di Venere, L., Díaz, C., Diebold, S., Dinesh, A., Djuvsland, J., Dominik, R. M., Prester, D. Dominis, Donini, A., Dorner, D., Dörner, J., Doro, M., Dournaux, J. -L., Duangchan, C., Dubos, C., Ducci, L., Dwarkadas, V. V., Ebr, J., Eckner, C., Egberts, K., Einecke, S., Elsässer, D., Emery, G., Errando, M., Escanuela, C., Escarate, P., Godoy, M. Escobar, Escudero, J., Esposito, P., Ettori, S., Falceta-Goncalves, D., Fedorova, E., Fegan, S., Feng, Q., Ferrand, G., Ferrarotto, F., Fiandrini, E., Fiasson, A., Filipovic, M., Fioretti, V., Fiori, M., Foffano, L., Guiteras, L. Font, Fontaine, G., Fröse, S., Fukazawa, Y., Fukui, Y., Furniss, A., Galanti, G., Galaz, G., Galelli, C., Gallozzi, S., Gammaldi, V., Garczarczyk, M., Gasbarra, C., Gasparrini, D., Ghalumyan, A., Gianotti, F., Giarrusso, M., Paiva, J. G. Giesbrecht Formiga, Giglietto, N., Giordano, F., Giuffrida, R., Glicenstein, J. -F., Glombitza, J., Goldoni, P., González, J. M., González, M. M., Coelho, J. Goulart, Gradetzke, T., Granot, J., Grasso, D., Grau, R., Gréaux, L., Green, D., Green, J. G., Grolleron, G., Guedes, L. M. V., Gueta, O., Hackfeld, J., Hadasch, D., Hamal, P., Hanlon, W., Hara, S., Harvey, V. M., Hassan, T., Hayashi, K., Heß, B., Heckmann, L., Heller, M., Cadena, S. Hernández, Hervet, O., Hinton, J., Hiroshima, N., Hnatyk, B., Hnatyk, R., Hofmann, W., Holder, J., Horan, D., Horvath, P., Hovatta, T., Hrabovsky, M., Hrupec, D., Iarlori, M., Inada, T., Incardona, F., Inoue, S., Inoue, Y., Iocco, F., Iori, M., Ishio, K., Jamrozy, M., Janecek, P., Jankowsky, F., Jean, P., Quiles, J. Jimenez, Jin, W., Juramy-Gilles, C., Jurysek, J., Kagaya, M., Kalekin, O., Karas, V., Katagiri, H., Kataoka, J., Kaufmann, S., Kazanas, D., Kerszberg, D., Kieda, D. B., Kleiner, T., Kluge, G., Kobayashi, Y., Kohri, K., Komin, N., Kornecki, P., Kosack, K., Kowal, G., Kubo, H., Kushida, J., La Barbera, A., La Palombara, N., Láinez, M., Lamastra, A., Lapington, J., Laporte, P., Lazarević, S., Lazendic-Galloway, J., Lemoine-Goumard, M., Lenain, J. -P., Leone, F., Leonora, E., Leto, G., Lindfors, E., Linhoff, M., Liodakis, I., Lipniacka, A., Lombardi, S., Longo, F., López-Coto, R., López-Moya, M., López-Oramas, A., Loporchio, S., Bahilo, J. Lozano, Luque-Escamilla, P. L., Macias, O., Majumdar, P., Mallamaci, M., Malyshev, D., Mandat, D., Manicò, G., Mariotti, M., Márquez, I., Marquez, P., Marsella, G., Martí, J., Martínez, G. A., Martínez, M., Martinez, O., Marty, C., Mas-Aguilar, A., Mastropietro, M., Mazin, D., Menchiari, S., Mestre, E., Meunier, J. -L., Meyer, D. M. -A., Meyer, M., Miceli, D., Miceli, M., Michailidis, M., Michałowski, J., Miener, T., Miranda, J. M., Mitchell, A., Mizote, M., Mizuno, T., Moderski, R., Molero, M., Molfese, C., Molina, E., Montaruli, T., Moralejo, A., Morcuende, D., Morselli, A., Moulin, E., Zamanillo, V. Moya, Munari, K., Murach, T., Muraczewski, A., Muraishi, H., Nakamori, T., Nayak, A., Nemmen, R., Neto, J. P., Nickel, L., Niemiec, J., Nieto, D., Rosillo, M. Nievas, Nikołajuk, M., Nikolić, L., Nishijima, K., Noda, K., Nosek, D., Novotny, V., Nozaki, S., Ohishi, M., Ohtani, Y., Okumura, A., Olive, J. -F., Ong, R. A., Orienti, M., Orito, R., Orlandini, M., Orlando, E., Orlando, S., Ostrowski, M., Otero-Santos, J., Oya, I., Pagano, I., Pagliaro, A., Palatiello, M., Panebianco, G., Paneque, D., Pantaleo, F. R., Paredes, J. M., Parmiggiani, N., Patricelli, B., Pe'er, A., Pech, M., Pecimotika, M., Pensec, U., Peresano, M., Pérez-Romero, J., Persic, M., Peters, K. P., Petruk, O., Piano, G., Pierre, E., Pietropaolo, E., Pihet, M., Pinchbeck, L., Pirola, G., Pittori, C., Plard, C., Podobnik, F., Pohl, M., Pollet, V., Ponti, G., Prandini, E., Principe, G., Priyadarshi, C., Produit, N., Prouza, M., Pueschel, E., Pühlhofer, G., Pumo, M. L., Queiroz, F., Quirrenbach, A., Rainò, S., Rando, R., Razzaque, S., Regeard, M., Reimer, A., Reimer, O., Reisenegger, A., Rhode, W., Ribeiro, D., Ribó, M., Ricci, C., Richtler, T., Rico, J., Rieger, F., Riitano, L., Rizi, V., Roache, E., Fernandez, G. Rodriguez, Frías, M. D. Rodríguez, Rodríguez-Vázquez, J. J., Romano, P., Romeo, G., Rosado, J., de Leon, A. 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F., Tosti, G., Tothill, N., Toussenel, F., Tramacere, A., Travnicek, P., Tripodo, G., Trois, A., Truzzi, S., Tutone, A., Vaclavek, L., Vacula, M., Vallania, P., Vallés, R., van Eldik, C., van Scherpenberg, J., Vandenbroucke, J., Vassiliev, V., Acosta, M. Vázquez, Vecchi, M., Ventura, S., Vercellone, S., Verna, G., Viana, A., Viaux, N., Vigliano, A., Vignatti, J., Vigorito, C. F., Villanueva, J., Visentin, E., Vitale, V., Vodeb, V., Voisin, V., Voitsekhovskyi, V., Vorobiov, S., Voutsinas, G., Vovk, I., Vuillaume, T., Wagner, S. J., Walter, R., White, M., White, R., Wierzcholska, A., Will, M., Williams, D. A., Wohlleben, F., Wolter, A., Yamamoto, T., Yang, L., Yoshida, T., Yoshikoshi, T., Zaharijas, G., Zampieri, L., Sanchez, R. Zanmar, Zavrtanik, D., Zavrtanik, M., Zdziarski, A. A., Zech, A., Zhang, W., Zhdanov, V. I., Ziętara, K., Živec, M., and Zuriaga-Puig, J.
- Abstract
Monochromatic gamma-ray signals constitute a potential smoking gun signature for annihilating or decaying dark matter particles that could relatively easily be distinguished from astrophysical or instrumental backgrounds. We provide an updated assessment of the sensitivity of the Cherenkov Telescope Array (CTA) to such signals, based on observations of the Galactic centre region as well as of selected dwarf spheroidal galaxies. We find that current limits and detection prospects for dark matter masses above 300 GeV will be significantly improved, by up to an order of magnitude in the multi-TeV range. This demonstrates that CTA will set a new standard for gamma-ray astronomy also in this respect, as the world's largest and most sensitive high-energy gamma-ray observatory, in particular due to its exquisite energy resolution at TeV energies and the adopted observational strategy focussing on regions with large dark matter densities. Throughout our analysis, we use up-to-date instrument response functions, and we thoroughly model the effect of instrumental systematic uncertainties in our statistical treatment. We further present results for other potential signatures with sharp spectral features, e.g.~box-shaped spectra, that would likewise very clearly point to a particle dark matter origin., Comment: 43 pages JCAP style (excluding author list and references), 19 figures
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- 2024
42. Nonlinear feedback of the electrostatic instability on the blazar-induced pair beam and GeV cascade
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Alawashra, Mahmoud, Pohl, Martin, Alawashra, Mahmoud, and Pohl, Martin
- Abstract
Relativistic pair beams produced in the cosmic voids by TeV gamma rays from blazars are expected to produce a detectable GeV-scale cascade that is missing in the observations. The suppression of this secondary cascade implies either the deflection of the pair beam by intergalactic magnetic fields or, alternatively, an energy loss of the beam due to the beam-plasma instability. Here, we study how the beam-plasma instability feeds back on the beam, using a realistic two-dimensional beam distribution. We find that the instability broadens the beam opening angles significantly without any significant energy loss, thus confirming a recent feedback study on a simplified one-dimensional beam distribution. However, narrowing diffusion feedback of the beam particles with Lorentz factors less than $10^6$ might become relevant even though initially it is negligible. Finally, when considering the continuous creation of TeV pairs, we find that the beam distribution and the wave spectrum reach a new quasi-steady state, in which the scattering of beam particles persists and the beam opening angle may increase by a factor of hundreds. Understanding the implications on the GeV cascade emission requires accounting for inverse-Compton cooling., Comment: Accepted for publication in the Astrophysical Journal. 16 pages and 12 figures
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- 2024
43. Robust inference of the Galactic centre gamma-ray excess spatial properties
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Song, Deheng, Eckner, Christopher, Gordon, Chris, Calore, Francesca, Macias, Oscar, Abazajian, Kevork N., Horiuchi, Shunsaku, Kaplinghat, Manoj, Pohl, Martin, Song, Deheng, Eckner, Christopher, Gordon, Chris, Calore, Francesca, Macias, Oscar, Abazajian, Kevork N., Horiuchi, Shunsaku, Kaplinghat, Manoj, and Pohl, Martin
- Abstract
The gamma-ray Fermi-LAT Galactic centre excess (GCE) has puzzled scientists for over 15 years. Despite ongoing debates about its properties, and especially its spatial distribution, its nature remains elusive. We scrutinize how the estimated spatial morphology of this excess depends on models for the Galactic diffuse emission, focusing particularly on the extent to which the Galactic plane and point sources are masked. Our main aim is to compare a spherically symmetric morphology - potentially arising from the annihilation of dark matter (DM) particles - with a boxy morphology - expected if faint unresolved sources in the Galactic bulge dominate the excess emission. Recent claims favouring a DM-motivated template for the GCE are shown to rely on a specific Galactic bulge template, which performs worse than other templates for the Galactic bulge. We find that a non-parametric model of the Galactic bulge derived from the VVV survey results in a significantly better fit for the GCE than DM-motivated templates. This result is independent of whether a GALPROP-based model or a more non-parametric ring-based model is used to describe the diffuse Galactic emission. This conclusion remains true even when additional freedom is added in the background models, allowing for non-parametric modulation of the model components and substantially improving the fit quality. When adopted, optimized background models provide robust results in terms of preference for a boxy bulge morphology of the GCE, regardless of the mask applied to the Galactic plane., Comment: 21 pages, 11 figures
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- 2024
44. Gastrisches versus supragastrisches „belching“, Singultus, Aerophagie und Differenzialdiagnosen
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Runggaldier, Daniel, Adam, Roman, Ermanni, Chiara, Colotto-Vith, Ursula, van Beek, Miriam E F, Posovszky, Carsten; https://orcid.org/0000-0002-9487-8812, Righini Grunder, Franziska, Pohl, Daniel; https://orcid.org/0000-0002-0855-1152, Bohlender, Jörg E, Runggaldier, Daniel, Adam, Roman, Ermanni, Chiara, Colotto-Vith, Ursula, van Beek, Miriam E F, Posovszky, Carsten; https://orcid.org/0000-0002-9487-8812, Righini Grunder, Franziska, Pohl, Daniel; https://orcid.org/0000-0002-0855-1152, and Bohlender, Jörg E
- Abstract
Das als „belching“ bezeichnete Aufstoßen von Luft aus dem Ösophagus oder Magen in den Mund- und Rachenbereich gilt als physiologischer Prozess. Es kann jedoch in einem vermehrten Maße auftreten und im Sinne einer „belching disorder“ für die betroffenen Patienten mit einem erheblichen Leidensdruck verbunden sein. Die Diagnosestellung gestaltet sich zum Teil schwierig, insbesondere in Hinblick auf die Abgrenzung zu verwandten Krankheitsbildern wie der Aerophagie, dem Ruminationssyndrom oder dem Singultus. Neben der Diagnosestellung stellt auch die Therapie dieser Störungsbilder für den Hals-Nasen-Ohren-Arzt eine Herausforderung dar. Ziel dieser Arbeit ist es, eine interdisziplinäre Übersicht zu diesen Krankheitsbildern zu schaffen und klinisch-praktische Gesichtspunkte zur Diagnosestellung und Therapie aufzuarbeiten.
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- 2024
45. The prevalence of head and face pain decreased from 1997 to 2017 in Switzerland
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Pohl, Heiko; https://orcid.org/0000-0002-2778-6790, Neumeier, Maria Susanne; https://orcid.org/0000-0001-6410-5547, Hänsel, Martin; https://orcid.org/0000-0001-9300-1130, Wegener, Susanne; https://orcid.org/0000-0003-4369-7023, Pohl, Heiko; https://orcid.org/0000-0002-2778-6790, Neumeier, Maria Susanne; https://orcid.org/0000-0001-6410-5547, Hänsel, Martin; https://orcid.org/0000-0001-9300-1130, and Wegener, Susanne; https://orcid.org/0000-0003-4369-7023
- Abstract
Background: Pain in the head and the face is highly prevalent but may have changed during the past years. This study aimed to analyze changes in the prevalence of pain in the head and the face in Switzerland from 1997 to 2017. Methods: This is a secondary analysis of data collected in the Swiss Health Surveys of 1997–2017. Included persons were 15 years and older. Besides studying demographic data, we analyze the item assessing the presence of “headache, pressure in the head, or facial pain” during the past 4 weeks. Percentages with their Wilson confidence intervals are reported for each response option of categorical variables. Moreover, we calculate the age‐standardized number of persons affected by the pain. Results: While 41% reported head and face pain in 1997, the proportion dropped to 31% in 2017. There was a decrease of 19.5% in women and 29.4% in men; after age standardization, the decrease was 16.5% in women and 25.4% in men. The most considerable numerical changes in the percentages of women with pain occurred in those aged 55–69 and 85 and above. In men, the changes were not limited to specific age groups. Conclusions: The proportion of people reporting headaches, pressure in the head, or facial pain has dropped in Switzerland from 1997 to 2017. However, in women, the prevalence diminished more strongly and consistently in the middle‐aged and the elderly than in the young.
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- 2024
46. Hilfe, ich kann nicht rülpsen: Falldarstellung und Kurzübersicht zur retrograden krikopharyngealen Dysfunktion
- Author
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Runggaldier, Daniel, Colotto-Vith, Ursula, Pohl, Daniel, Bohlender, Jörg E, Runggaldier, Daniel, Colotto-Vith, Ursula, Pohl, Daniel, and Bohlender, Jörg E
- Abstract
In dieser Kurzübersicht wird das erstmalig 2019 durch den Laryngologen Dr. Bastian beschriebene Syndrom der retrograden krikopharyngealen Dysfunktion (R-CPD) anhand eines klassischen Falls vorgestellt. Die Diagnose erfolgt in der Regel klinisch durch die klassischen Symptome wie beispielsweise die Unfähigkeit, Luft aufzustoßen, abdominales Blähgefühl und retrosternale gurgelnde Geräusche. Des Weiteren werden neue Möglichkeiten der Diagnosesicherung mittels hochauflösender Ösophagusmanometrie und die therapeutischen Möglichkeiten mittels Injektion von Botulinumtoxin in den M. cricopharyngeus beschrieben sowie die dazu publizierten Daten diskutiert. // In this short communication, we discuss the recently described syndrome of retrograde cricopharyngeal dysfunction (R-CPD) with its first description in 2019 by the laryngologist Dr. Bastian. Diagnosis is generally based on typical clinical symptoms, e.g., the inability to belch, a bloated abdomen and retrosternal gurgling noises. We also describe high-resolution esophageal manometry as a new tool to further secure the diagnosis of R‑CPD, as well as therapeutic options such as botulinum toxin injections in the cricopharyngeal muscle or cricopharyngeal myotomy and the published data thereon.
- Published
- 2024
47. Knowledge work characteristics and innovative behaviour: a fuzzy-set qualitative comparative analysis (fsQCA)
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Fréour, Léa, Pohl, Sabine, Battistelli, Adalgisa, Cangialosi, Nicola, Fréour, Léa, Pohl, Sabine, Battistelli, Adalgisa, and Cangialosi, Nicola
- Abstract
0, info:eu-repo/semantics/published
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- 2024
48. Metastable patterns in one- and two-component dipolar Bose-Einstein condensates
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Zhang, Yong Chang (author), Pohl, Thomas (author), Maucher, F. (author), Zhang, Yong Chang (author), Pohl, Thomas (author), and Maucher, F. (author)
- Abstract
In this paper we study metastable states in single- and two-component dipolar Bose-Einstein condensates. We show that this system supports a rich variety of states that are remarkably stable despite not being ground states. In a parameter region where striped phases are ground states, we find such metastable states that are energetically favorable compared to triangular and honeycomb lattices. Among these metastable states we report a peculiar ring-lattice state, which is led by the competition between triangular and honeycomb symmetries and rarely seen in other systems. In the case of dipolar mixtures we show that via tuning the miscibility these states can be stabilized in a broader domain by utilizing interspecies interactions., Optical Technologies
- Published
- 2024
- Full Text
- View/download PDF
49. Un-/sichere Orte : Perspektiven von Kindern und Jugendlichen in der stationären Kinder- und Jugendhilfe
- Author
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Pohl, Carina and Pohl, Carina
- Abstract
Sowohl das sicher fühlen als auch das sicher sein beeinflusst das Wohlbefinden und den Lebensverlauf der Kinder massgeblich. Dabei zeigt sich in den Narrationen der Kinder, dass verschiedene Dimensionen (z.B. Raum, Beziehung, Struktur, Biografie) ihr Sicherheits- und Unsicherheitsempfinden beeinflussen. In Bezug auf stationäre Kontexte empfinden Kinder diesen Ort als sicher und unsicher zugleich. Einflussfaktoren sind z.B. erlebte Gewalt in Einrichtungen, die Qualität der Beziehungen, Machtungleichheiten und die Abgeschlossenheit des Ortes.
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- 2024
50. Balance of power in interviews with children : how to deal with generational order and other ethical challenges
- Author
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Pohl, Carina and Pohl, Carina
- Published
- 2024
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